Cytochrome c oxidase subunit 4

Overview
NameCytochrome c oxidase subunit 4
Smed IDSMED30025809
Length (bp)727
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Cytochrome c oxidase subunit 4 (SMED30025809) t-SNE clustered cells

Violin plots show distribution of expression levels for Cytochrome c oxidase subunit 4 (SMED30025809) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cytochrome c oxidase subunit 4 (SMED30025809) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Cytochrome c oxidase subunit 4 (SMED30025809) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30025809

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30025809h1SMcG0007471 dd_Smed_v4_845_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30025809h1SMcG0007471 dd_Smed_v4_845_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30025809h1SMcG0007471 dd_Smed_v4_845_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30025809h1SMcG0007471 dd_Smed_v4_845_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30025809h1SMcG0007471 dd_Smed_v4_845_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Human
Match: COX4I2 (cytochrome c oxidase subunit 4I2 [Source:HGNC Symbol;Acc:HGNC:16232])

HSP 1 Score: 81.2629 bits (199), Expect = 1.906e-18
Identity = 45/117 (38.46%), Postives = 64/117 (54.70%), Query Frame = 3 
Query:  288 EYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            E +     LK KE   W+ LT  EK  LYR+ +  T AE+   + EW      VF  +GFA L+  + R+Y+  P+ P TLT+E +   L R +     PV G+AS+WDY+K  WK+
Sbjct:   56 ELNAEEQALKEKEKGSWTQLTHAEKVALYRLQFNETFAEMNRRSNEWKTVMGCVFFFIGFAALVIWWQRVYVFPPK-PITLTDERKAQQLQRMLDMKVNPVQGLASRWDYEKKQWKK 171
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Human
Match: COX4I1 (cytochrome c oxidase subunit 4I1 [Source:HGNC Symbol;Acc:HGNC:2265])

HSP 1 Score: 80.1073 bits (196), Expect = 3.941e-18
Identity = 45/135 (33.33%), Postives = 71/135 (52.59%), Query Frame = 3 
Query:  237 PDYFDHTLFPYPAIRWQEYDENNLK-LKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            P Y D    P P +   ++   + K LK KE   WS L+++EK +LYRI ++ + AE+  G+ EW          +GF  L+  + + Y+ GP LP++  +E       R +     P+ G+ASKWDY+K  WK+
Sbjct:   36 PAYMDRRDHPLPEVAHVKHLSASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMWQKHYVYGP-LPQSFDKEWVAKQTKRMLDMKVNPIQGLASKWDYEKNEWKK 169
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Human
Match: COX4I1 (cytochrome c oxidase subunit 4I1 [Source:HGNC Symbol;Acc:HGNC:2265])

HSP 1 Score: 80.1073 bits (196), Expect = 3.941e-18
Identity = 45/135 (33.33%), Postives = 71/135 (52.59%), Query Frame = 3 
Query:  237 PDYFDHTLFPYPAIRWQEYDENNLK-LKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            P Y D    P P +   ++   + K LK KE   WS L+++EK +LYRI ++ + AE+  G+ EW          +GF  L+  + + Y+ GP LP++  +E       R +     P+ G+ASKWDY+K  WK+
Sbjct:   36 PAYMDRRDHPLPEVAHVKHLSASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMWQKHYVYGP-LPQSFDKEWVAKQTKRMLDMKVNPIQGLASKWDYEKNEWKK 169
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Human
Match: COX4I1 (cytochrome c oxidase subunit 4I1 [Source:HGNC Symbol;Acc:HGNC:2265])

HSP 1 Score: 80.1073 bits (196), Expect = 3.941e-18
Identity = 45/135 (33.33%), Postives = 71/135 (52.59%), Query Frame = 3 
Query:  237 PDYFDHTLFPYPAIRWQEYDENNLK-LKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            P Y D    P P +   ++   + K LK KE   WS L+++EK +LYRI ++ + AE+  G+ EW          +GF  L+  + + Y+ GP LP++  +E       R +     P+ G+ASKWDY+K  WK+
Sbjct:   36 PAYMDRRDHPLPEVAHVKHLSASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMWQKHYVYGP-LPQSFDKEWVAKQTKRMLDMKVNPIQGLASKWDYEKNEWKK 169
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Human
Match: COX4I1 (cytochrome c oxidase subunit 4I1 [Source:HGNC Symbol;Acc:HGNC:2265])

HSP 1 Score: 55.4546 bits (132), Expect = 1.411e-9
Identity = 33/101 (32.67%), Postives = 54/101 (53.47%), Query Frame = 3 
Query:  240 DYFDHTLFPYPAIRWQEYDENNLK-LKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEE 539
            D  DH   P P +   ++   + K LK KE   WS L+++EK +LYRI ++ + AE+  G+ EW          +GF  L+  + + Y+ GP LP++  +E
Sbjct:    2 DRRDH---PLPEVAHVKHLSASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMWQKHYVYGP-LPQSFDKE 98
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Celegans
Match: cox-4 (Cytochrome OXidase assembly protein [Source:UniProtKB/TrEMBL;Acc:Q9U329])

HSP 1 Score: 82.8037 bits (203), Expect = 1.681e-19
Identity = 49/148 (33.11%), Postives = 76/148 (51.35%), Query Frame = 3 
Query:  192 QIGNREIVGYGTSGAPDYFDHTLFPYPAIRWQEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWK 635
            +   RE+VGYG +G   Y D   + YPAIR+++ D     +++KE  DW  L+ EEKK LYR S+R T++E  +    W    A++ ++LG     A  + +  V PELP T   E +   + R +        G  + +DY+   WK
Sbjct:   29 KAAGRELVGYGANGDNIYQDRLDYWYPAIRFRKEDSVIAPIRAKEQADWKNLSAEEKKLLYRYSFRQTLSEFEAPTGYWKVISAVILSVLGLCTYYAVLLNV-CVYPELPPTFQNEYKEAQVERALVLEKGQFLGAPTHYDYENKKWK 175
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Fly
Match: COX4 (gene:FBgn0032833 transcript:FBtr0081300)

HSP 1 Score: 105.916 bits (263), Expect = 4.098e-28
Identity = 58/150 (38.67%), Postives = 82/150 (54.67%), Query Frame = 3 
Query:  186 FPQIGNREIVGYGTSGAPDYFDHTLFPYPAIRWQEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWK 635
              +IG REIVGYG +G   Y D   +P PA+R++E       L++KE  DW  L+ +E K LYR S+  TIAE+ +G+ EW     +       A+ +A  + +++   ELP T  EE +   L R I     PVTG+ SKWDY+   WK
Sbjct:   33 LDKIGKREIVGYGWNGTACYADRVDYPLPAVRFREPTNEINALRAKEQGDWKKLSTQEIKALYRASFCQTIAEVQAGSGEWKLHLGVSLLFCAAAIWVAVLMNIFVY-DELPVTFDEEHQKAQLQRIIDLEINPVTGLTSKWDYENKKWK 181
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Fly
Match: COX4 (gene:FBgn0032833 transcript:FBtr0332243)

HSP 1 Score: 105.916 bits (263), Expect = 4.098e-28
Identity = 58/150 (38.67%), Postives = 82/150 (54.67%), Query Frame = 3 
Query:  186 FPQIGNREIVGYGTSGAPDYFDHTLFPYPAIRWQEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWK 635
              +IG REIVGYG +G   Y D   +P PA+R++E       L++KE  DW  L+ +E K LYR S+  TIAE+ +G+ EW     +       A+ +A  + +++   ELP T  EE +   L R I     PVTG+ SKWDY+   WK
Sbjct:   33 LDKIGKREIVGYGWNGTACYADRVDYPLPAVRFREPTNEINALRAKEQGDWKKLSTQEIKALYRASFCQTIAEVQAGSGEWKLHLGVSLLFCAAAIWVAVLMNIFVY-DELPVTFDEEHQKAQLQRIIDLEINPVTGLTSKWDYENKKWK 181
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Fly
Match: COX4 (gene:FBgn0032833 transcript:FBtr0081301)

HSP 1 Score: 105.916 bits (263), Expect = 4.098e-28
Identity = 58/150 (38.67%), Postives = 82/150 (54.67%), Query Frame = 3 
Query:  186 FPQIGNREIVGYGTSGAPDYFDHTLFPYPAIRWQEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWK 635
              +IG REIVGYG +G   Y D   +P PA+R++E       L++KE  DW  L+ +E K LYR S+  TIAE+ +G+ EW     +       A+ +A  + +++   ELP T  EE +   L R I     PVTG+ SKWDY+   WK
Sbjct:   33 LDKIGKREIVGYGWNGTACYADRVDYPLPAVRFREPTNEINALRAKEQGDWKKLSTQEIKALYRASFCQTIAEVQAGSGEWKLHLGVSLLFCAAAIWVAVLMNIFVY-DELPVTFDEEHQKAQLQRIIDLEINPVTGLTSKWDYENKKWK 181
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Fly
Match: COX4 (gene:FBgn0032833 transcript:FBtr0332242)

HSP 1 Score: 105.916 bits (263), Expect = 4.098e-28
Identity = 58/150 (38.67%), Postives = 82/150 (54.67%), Query Frame = 3 
Query:  186 FPQIGNREIVGYGTSGAPDYFDHTLFPYPAIRWQEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWK 635
              +IG REIVGYG +G   Y D   +P PA+R++E       L++KE  DW  L+ +E K LYR S+  TIAE+ +G+ EW     +       A+ +A  + +++   ELP T  EE +   L R I     PVTG+ SKWDY+   WK
Sbjct:   33 LDKIGKREIVGYGWNGTACYADRVDYPLPAVRFREPTNEINALRAKEQGDWKKLSTQEIKALYRASFCQTIAEVQAGSGEWKLHLGVSLLFCAAAIWVAVLMNIFVY-DELPVTFDEEHQKAQLQRIIDLEINPVTGLTSKWDYENKKWK 181
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Fly
Match: COX4L (gene:FBgn0033020 transcript:FBtr0335260)

HSP 1 Score: 102.834 bits (255), Expect = 3.589e-27
Identity = 53/147 (36.05%), Postives = 82/147 (55.78%), Query Frame = 3 
Query:  195 IGNREIVGYGTSGAPDYFDHTLFPYPAIRWQEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWK 635
            + +R++VG+G +G P YFD    P+PAIR++E       L+ KE +DW  L+L+EKK+LYR S+  T AE      EW     +   L+   + ++  ++  + G +LP T  +E +   L R I     P+TG+ASKW Y +  WK
Sbjct:   17 VADRQVVGHGINGRPIYFDSPDCPFPAIRYREVSPELCALREKELDDWKKLSLDEKKQLYRYSFCQTYAEFQHITPEWKMCLGVALWLVSIGIAISITMKTVLYG-KLPDTFNDERQSAQLRRIIQLQMNPITGLASKWCYRENKWK 162
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Zebrafish
Match: cox4i1 (cytochrome c oxidase subunit 4I1 [Source:ZFIN;Acc:ZDB-GENE-030131-5175])

HSP 1 Score: 87.8113 bits (216), Expect = 3.796e-21
Identity = 48/135 (35.56%), Postives = 72/135 (53.33%), Query Frame = 3 
Query:  237 PDYFDHTLFPYPAIRW-QEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            P YFD    P P I++ Q+   +   LK KE   W+ L+ EEK  LYRIS++ + AE+  G+ EW    A +F  +G   L+  + R Y+ G ++P T   E +   + R +     PV G A+KWDY+   WK+
Sbjct:   36 PAYFDRRESPLPEIKFVQQLSADQKSLKEKEKGSWAALSKEEKIALYRISFKESFAEMNQGSGEWKSVVAGIFFFVGLTGLVVLWQRKYVYG-DVPNTFDPEYKQKEIQRMLDMRINPVQGFAAKWDYENNAWKK 169
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Zebrafish
Match: cox4i1 (cytochrome c oxidase subunit 4I1 [Source:ZFIN;Acc:ZDB-GENE-030131-5175])

HSP 1 Score: 87.8113 bits (216), Expect = 3.796e-21
Identity = 48/135 (35.56%), Postives = 72/135 (53.33%), Query Frame = 3 
Query:  237 PDYFDHTLFPYPAIRW-QEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            P YFD    P P I++ Q+   +   LK KE   W+ L+ EEK  LYRIS++ + AE+  G+ EW    A +F  +G   L+  + R Y+ G ++P T   E +   + R +     PV G A+KWDY+   WK+
Sbjct:   36 PAYFDRRESPLPEIKFVQQLSADQKSLKEKEKGSWAALSKEEKIALYRISFKESFAEMNQGSGEWKSVVAGIFFFVGLTGLVVLWQRKYVYG-DVPNTFDPEYKQKEIQRMLDMRINPVQGFAAKWDYENNAWKK 169
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Zebrafish
Match: cox4i2 (cytochrome c oxidase subunit 4I2 [Source:ZFIN;Acc:ZDB-GENE-040426-1775])

HSP 1 Score: 75.8702 bits (185), Expect = 1.435e-16
Identity = 47/147 (31.97%), Postives = 71/147 (48.30%), Query Frame = 3 
Query:  198 GNREIVGYGTSGAPDYFDHTLFPYPAIRWQE-YDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWK 635
            G+ +++       P Y D    P P   +++     +  LK KE   W+ L+ EEK  LYRI +  T AE+     EW    A +   +GF  L+  + RLY+  P+ P T  +E +   + R +     PV G A+KWDY+K  WK
Sbjct:   32 GHGDVIEQADMSRPMYSDRLDTPLPDRPYKDILSAADKSLKQKEKGPWNNLSNEEKIALYRIMFNETFAEMKKPTGEWKTVTAGILFFIGFTGLVVLWQRLYVYPPQ-PHTFGDEWQAKQIKRMLDMKINPVQGFAAKWDYEKGQWK 177
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Zebrafish
Match: cox4i1l (cytochrome c oxidase subunit 4I1, like [Source:ZFIN;Acc:ZDB-GENE-130814-2])

HSP 1 Score: 72.7886 bits (177), Expect = 1.403e-15
Identity = 37/100 (37.00%), Postives = 59/100 (59.00%), Query Frame = 3 
Query:  336 WSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWK 635
            W+ L+ EEK  +YR+++ L+  E+  G+ EW+   A VF  LGF  L+  + R+++ G ++P TL++E       R +     P+TG A KWDY+K  WK
Sbjct:   75 WTQLSKEEKLAIYRLTHELSFPEMRKGSKEWMTVLAGVFFFLGFTGLLVWWQRVFVYG-DVPHTLSQEWIEKQTQRMLDMKVNPITGFAHKWDYEKKQWK 173
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Zebrafish
Match: cox4i1l (cytochrome c oxidase subunit 4I1, like [Source:ZFIN;Acc:ZDB-GENE-130814-2])

HSP 1 Score: 72.7886 bits (177), Expect = 1.403e-15
Identity = 37/100 (37.00%), Postives = 59/100 (59.00%), Query Frame = 3 
Query:  336 WSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWK 635
            W+ L+ EEK  +YR+++ L+  E+  G+ EW+   A VF  LGF  L+  + R+++ G ++P TL++E       R +     P+TG A KWDY+K  WK
Sbjct:   75 WTQLSKEEKLAIYRLTHELSFPEMRKGSKEWMTVLAGVFFFLGFTGLLVWWQRVFVYG-DVPHTLSQEWIEKQTQRMLDMKVNPITGFAHKWDYEKKQWK 173
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Xenopus
Match: maml1 (mastermind like transcriptional coactivator 1 [Source:Xenbase;Acc:XB-GENE-1033859])

HSP 1 Score: 78.1814 bits (191), Expect = 3.016e-17
Identity = 51/135 (37.78%), Postives = 69/135 (51.11%), Query Frame = 3 
Query:  237 PDYFDHTLFPYPAIRW-QEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGN-CEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWK 635
            P Y +   +P P + +  E +     LK KE   W  LT EEK  LYRIS+  + AE+ SG+  EW      V   L F  L   + R+Y+ GP +P TL+E+   +   R I     PVTG +S WDY+K  WK
Sbjct:   47 PMYCERREYPLPDVPFVSELNPQQKALKLKENGPWGQLTKEEKLALYRISFNQSYAEMHSGSKSEWKTIVGAVLYFLAFGGLYLWWHRIYVYGP-VPHTLSEDWVAMQAKRMIDMRINPVTGFSSHWDYEKKQWK 180
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Xenopus
Match: cox4i1 (cytochrome c oxidase subunit IV isoform 1 [Source:NCBI gene;Acc:549233])

HSP 1 Score: 74.7146 bits (182), Expect = 3.987e-16
Identity = 46/148 (31.08%), Postives = 73/148 (49.32%), Query Frame = 3 
Query:  198 GNREIVGYGTSGAPDYFDHTLFPYPAIRWQEYDENNLK-LKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            G+  +V   T   P Y D    P P I + E   +  K LK KE   W+ L+ +EK +LYRI ++ + +E+  G+ EW          +GF   +  + R Y+ G ++P T +++       R +     P+ G +SKWDYDK  WK+
Sbjct:   23 GHAAVVKPETYSLPVYVDRRNVPLPDIAFVETLSSEQKALKEKEKGTWASLSAKEKLELYRIKFQESYSEMNQGSSEWKTILGGTLFFIGFTAFVILWQRKYVYG-DVPHTFSDDWVAKQAKRMLDMRINPIQGFSSKWDYDKNEWKK 169
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Mouse
Match: Cox4i1 (cytochrome c oxidase subunit 4I1 [Source:MGI Symbol;Acc:MGI:88473])

HSP 1 Score: 78.1814 bits (191), Expect = 1.417e-17
Identity = 44/135 (32.59%), Postives = 67/135 (49.63%), Query Frame = 3 
Query:  237 PDYFDHTLFPYPAIRWQEYDENNLK-LKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            P Y D   +P P +        + K LK KE  DWS L+ +EK +LYRI +  + AE+  G  EW     +    +GF  L+  + + Y+ GP +P T   +   +   R +     P+ G ++KWDYDK  WK+
Sbjct:   36 PTYADRRDYPLPDVAHVTMLSASQKALKEKEKADWSSLSRDEKVQLYRIQFNESFAEMNRGTNEWKTVVGMAMFFIGFTALVLIWEKSYVYGP-IPHTFDRDWVAMQTKRMLDMKANPIQGFSAKWDYDKNEWKK 169
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Mouse
Match: Cox4i1 (cytochrome c oxidase subunit 4I1 [Source:MGI Symbol;Acc:MGI:88473])

HSP 1 Score: 78.1814 bits (191), Expect = 1.417e-17
Identity = 44/135 (32.59%), Postives = 67/135 (49.63%), Query Frame = 3 
Query:  237 PDYFDHTLFPYPAIRWQEYDENNLK-LKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            P Y D   +P P +        + K LK KE  DWS L+ +EK +LYRI +  + AE+  G  EW     +    +GF  L+  + + Y+ GP +P T   +   +   R +     P+ G ++KWDYDK  WK+
Sbjct:   36 PTYADRRDYPLPDVAHVTMLSASQKALKEKEKADWSSLSRDEKVQLYRIQFNESFAEMNRGTNEWKTVVGMAMFFIGFTALVLIWEKSYVYGP-IPHTFDRDWVAMQTKRMLDMKANPIQGFSAKWDYDKNEWKK 169
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Mouse
Match: Cox4i2 (cytochrome c oxidase subunit 4I2 [Source:MGI Symbol;Acc:MGI:2135755])

HSP 1 Score: 73.559 bits (179), Expect = 8.764e-16
Identity = 42/117 (35.90%), Postives = 61/117 (52.14%), Query Frame = 3 
Query:  288 EYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            E  E    LK KE   W+ L+  EK  LYR+ +  T AE+   + EW      VF  +GF  L+  + R+Y+  P+   TLTEE +   L R +     P+ G+A+ WDY+K  WK+
Sbjct:   57 ELSEEQRALKEKEKGSWTQLSQAEKVALYRLQFHETFAEMNHRSNEWKTVMGCVFFFIGFTALVIWWQRVYVF-PKKVVTLTEERKAQQLQRLLDMKSNPIQGLAAHWDYEKKEWKK 172
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Mouse
Match: Cox4i2 (cytochrome c oxidase subunit 4I2 [Source:MGI Symbol;Acc:MGI:2135755])

HSP 1 Score: 73.559 bits (179), Expect = 8.764e-16
Identity = 42/117 (35.90%), Postives = 61/117 (52.14%), Query Frame = 3 
Query:  288 EYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            E  E    LK KE   W+ L+  EK  LYR+ +  T AE+   + EW      VF  +GF  L+  + R+Y+  P+   TLTEE +   L R +     P+ G+A+ WDY+K  WK+
Sbjct:   57 ELSEEQRALKEKEKGSWTQLSQAEKVALYRLQFHETFAEMNHRSNEWKTVMGCVFFFIGFTALVIWWQRVYVF-PKKVVTLTEERKAQQLQRLLDMKSNPIQGLAAHWDYEKKEWKK 172
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Mouse
Match: Cox4i1 (cytochrome c oxidase subunit 4I1 [Source:MGI Symbol;Acc:MGI:88473])

HSP 1 Score: 54.6842 bits (130), Expect = 1.665e-9
Identity = 27/76 (35.53%), Postives = 41/76 (53.95%), Query Frame = 3 
Query:  312 LKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEE 539
            LK KE  DWS L+ +EK +LYRI +  + AE+  G  EW     +    +GF  L+  + + Y+ GP +P T   +
Sbjct:    9 LKEKEKADWSSLSRDEKVQLYRIQFNESFAEMNRGTNEWKTVVGMAMFFIGFTALVLIWEKSYVYGP-IPHTFDRD 83
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. UniProt/SwissProt
Match: sp|O46584|COX41_AOTAZ (Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Fragment) OS=Aotus azarae OX=30591 GN=COX4I1 PE=3 SV=1)

HSP 1 Score: 84.3445 bits (207), Expect = 3.276e-19
Identity = 47/135 (34.81%), Postives = 70/135 (51.85%), Query Frame = 3 
Query:  237 PDYFDHTLFPYPAIRWQEYDENNLK-LKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            P Y D   +P P +    +   + K LK KE   WS L+++EK +LYRI ++ + AE+  G+ EW          +GF  ++    + Y+ GP LP T  +E   +   R +     PV G+ASKWDYDK  WK+
Sbjct:   11 PSYVDRRDYPLPDVAHVRHLSASQKALKEKEKASWSSLSMDEKVELYRIQFKESFAEMNRGSNEWKTVVGAAMFFIGFTAILIILEKRYVYGP-LPHTFDKEWVAMQTKRMLDLKVNPVDGLASKWDYDKKEWKK 144
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. UniProt/SwissProt
Match: sp|O46578|COX41_GORGO (Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Fragment) OS=Gorilla gorilla gorilla OX=9595 GN=COX4I1 PE=3 SV=1)

HSP 1 Score: 81.2629 bits (199), Expect = 4.828e-18
Identity = 45/135 (33.33%), Postives = 72/135 (53.33%), Query Frame = 3 
Query:  237 PDYFDHTLFPYPAIRWQEYDENNLK-LKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            P Y D   +P P +   ++   + K LK KE   WS L+++EK +LYRI ++ + AE+  G+ EW          +GF  L+  + + Y+ GP LP++  +E       R +     P+ G+ASKWDY+K  WK+
Sbjct:   11 PAYMDRRDYPLPEVAHVKHLSASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMWQKHYVYGP-LPQSFDKEWVAKQTKRMLDMKVNPIQGLASKWDYEKNEWKK 144
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. UniProt/SwissProt
Match: sp|Q96KJ9|COX42_HUMAN (Cytochrome c oxidase subunit 4 isoform 2, mitochondrial OS=Homo sapiens OX=9606 GN=COX4I2 PE=1 SV=2)

HSP 1 Score: 81.2629 bits (199), Expect = 9.153e-18
Identity = 45/117 (38.46%), Postives = 64/117 (54.70%), Query Frame = 3 
Query:  288 EYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            E +     LK KE   W+ LT  EK  LYR+ +  T AE+   + EW      VF  +GFA L+  + R+Y+  P+ P TLT+E +   L R +     PV G+AS+WDY+K  WK+
Sbjct:   56 ELNAEEQALKEKEKGSWTQLTHAEKVALYRLQFNETFAEMNRRSNEWKTVMGCVFFFIGFAALVIWWQRVYVFPPK-PITLTDERKAQQLQRMLDMKVNPVQGLASRWDYEKKQWKK 171
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. UniProt/SwissProt
Match: sp|O46577|COX41_PANTR (Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Fragment) OS=Pan troglodytes OX=9598 GN=COX4I1 PE=3 SV=1)

HSP 1 Score: 80.1073 bits (196), Expect = 1.071e-17
Identity = 45/135 (33.33%), Postives = 71/135 (52.59%), Query Frame = 3 
Query:  237 PDYFDHTLFPYPAIRWQEYDENNLK-LKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            P Y D    P P +   ++   + K LK KE   WS L+++EK +LYRI ++ + AE+  G+ EW          +GF  L+  + + Y+ GP LP++  +E       R +     P+ G+ASKWDY+K  WK+
Sbjct:   11 PAYMDRRDHPLPEVAHVKHLSASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMWQKHYVYGP-LPQSFDKEWVAKQTKRMLDMKVNPIQGLASKWDYEKNEWKK 144
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. UniProt/SwissProt
Match: sp|P13073|COX41_HUMAN (Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Homo sapiens OX=9606 GN=COX4I1 PE=1 SV=1)

HSP 1 Score: 80.1073 bits (196), Expect = 1.893e-17
Identity = 45/135 (33.33%), Postives = 71/135 (52.59%), Query Frame = 3 
Query:  237 PDYFDHTLFPYPAIRWQEYDENNLK-LKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            P Y D    P P +   ++   + K LK KE   WS L+++EK +LYRI ++ + AE+  G+ EW          +GF  L+  + + Y+ GP LP++  +E       R +     P+ G+ASKWDY+K  WK+
Sbjct:   36 PAYMDRRDHPLPEVAHVKHLSASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMWQKHYVYGP-LPQSFDKEWVAKQTKRMLDMKVNPIQGLASKWDYEKNEWKK 169
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. TrEMBL
Match: A0A1I8HUC8 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig031254g3 PE=4 SV=1)

HSP 1 Score: 137.117 bits (344), Expect = 2.238e-36
Identity = 67/164 (40.85%), Postives = 101/164 (61.59%), Query Frame = 3 
Query:  147 ELSALILPAQKEYFPQIGNREIVGYGTSGAPDYFDHTLFPYPAIRWQEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            E+ ++I   Q   +PQ+G RE VG+G  G P+YFD  +FPYPAIR++E+D     L+ KE  DW+ L++E+KKKLYR S+R T +EL +    W  +  ++  +   A L   +++  +  P  PK+  EE  M S++++I   F PV GV+SKWDY+   WKE
Sbjct:   43 EMESVISNGQLSSYPQVGRREWVGHGRGGMPNYFDCLMFPYPAIRFREWDSAYEALRQKEKGDWNNLSIEDKKKLYRHSFRYTFSELEAPTGRWKLSIGILMLVFSGASLTMLFIK-KVFTPAFPKSFDEEWMMRSMWKQIMIGFNPVQGVSSKWDYENNRWKE 205
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. TrEMBL
Match: A0A1I8HY85 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig031254g1 PE=4 SV=1)

HSP 1 Score: 135.961 bits (341), Expect = 6.291e-36
Identity = 67/164 (40.85%), Postives = 99/164 (60.37%), Query Frame = 3 
Query:  147 ELSALILPAQKEYFPQIGNREIVGYGTSGAPDYFDHTLFPYPAIRWQEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            E+ ++I   Q   +PQ+G RE VG+G  G P+YFD  +FPYPAIR++E+D     L+ KE  DW  L++E+KKKLYR S+R T  EL +    W  +  ++  +   A L   +++  +  P  PK+  EE  M S++++I   F PV GV+SKWDY+   WKE
Sbjct:   43 EMESVISNGQLSSYPQVGRREWVGHGRGGMPNYFDCLMFPYPAIRFREWDSAYEALRQKEKGDWKNLSIEDKKKLYRHSFRYTFTELEAPTGRWKLSIGILMLVFSGASLTMLFIK-KVFTPAFPKSFDEEWMMRSMWKQIMIGFNPVQGVSSKWDYENNRWKE 205
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. TrEMBL
Match: A0A1I8JKZ7 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 133.65 bits (335), Expect = 6.035e-35
Identity = 66/165 (40.00%), Postives = 98/165 (59.39%), Query Frame = 3 
Query:  147 ELSALILPAQKEYFPQIGNREIVGYGTSGAPDYFDHTLFPYPAIRWQEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKEE 641
            E+ ++I   Q   +PQ+G RE VG+G  G P+YFD  +FPYPAIR++E+D     L+ KE  DW  L++E+KKKLYR S+R T  EL +    W  +  ++  +   A L   +++  +  P  PK+  EE  M S++++I   F PV GV+SKWDY+   WK  
Sbjct:   43 EMESVISNGQLSSYPQVGRREWVGHGRGGMPNYFDCLMFPYPAIRFREWDSAYEALRQKEKGDWKNLSIEDKKKLYRHSFRYTFTELEAPTGRWKLSIGILMLVFSGASLTMLFIK-KVFTPAFPKSFDEEWMMRSMWKQIMIGFNPVQGVSSKWDYENNRWKSN 206
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. TrEMBL
Match: A0A1S3D1T5 (cytochrome c oxidase subunit 4 isoform 2, mitochondrial OS=Diaphorina citri OX=121845 GN=LOC103509664 PE=4 SV=1)

HSP 1 Score: 131.724 bits (330), Expect = 1.494e-34
Identity = 72/159 (45.28%), Postives = 97/159 (61.01%), Query Frame = 3 
Query:  168 PAQKEYFPQIGNREIVGYGTSGAPDYFDHTLFPYPAIRWQEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVG--PELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            P  KE+F    NRE+VGYG +G P Y D+ +FPYP+IR++   +    LK KE  DW  LTLEEKK LYR S+  T  E+ +   EW   + + F ++  +LL  TYV +Y VG  PE  +TL+EE R   L + I   + P+TG ASKWDY+K  WK+
Sbjct:   33 PVAKEHFDFFPNREVVGYGFNGEPGYIDNPMFPYPSIRFKAITKELEPLKQKEKGDWKNLTLEEKKTLYRASFAQTFVEMNAPTGEWKGAFGIAFMVVTVSLL--TYVLMYKVGIFPEKAETLSEEHRQEMLQKMIDLRWNPITGTASKWDYEKNDWKK 189
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. TrEMBL
Match: Q0PWT8 (Cytochrome c oxidase polypeptide IV-like protein (Fragment) OS=Diaphorina citri OX=121845 PE=2 SV=1)

HSP 1 Score: 128.642 bits (322), Expect = 1.086e-33
Identity = 71/156 (45.51%), Postives = 96/156 (61.54%), Query Frame = 3 
Query:  177 KEYFPQIGNREIVGYGTSGAPDYFDHTLFPYPAIRWQEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVG--PELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            KE+F    NRE+VGYG +G P Y D+ +FPYP+IR++   +    LK KE  DW  LTLEEKK LYR S+  T  E+ +   EW   + + F ++  +LL  TYV +Y VG  PE  +TL+EE R   L + I   + P+TG ASKWDY+K  WK+
Sbjct:    2 KEHFDFFPNREVVGYGFNGEPGYIDNPMFPYPSIRFKAITKELEPLKQKEKGDWKNLTLEEKKTLYRASFAQTFVEMNAPTGEWKGAFGIAFMVVTVSLL--TYVLMYKVGIFPEKAETLSEEHRQEMLQKMIDLRWNPITGTASKWDYEKNDWKK 155
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Cavefish
Match: cox4i1 (cytochrome c oxidase subunit 4 isoform 1, mitochondrial [Source:NCBI gene;Acc:103031281])

HSP 1 Score: 85.1149 bits (209), Expect = 5.355e-20
Identity = 47/135 (34.81%), Postives = 70/135 (51.85%), Query Frame = 3 
Query:  237 PDYFDHTLFPYPAIRW-QEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            P YFD    P P I++ QE       LK KE   W+ L+++EK  LYRIS++ + AE+     EW    A +   LGF  ++  + R Y+ G ELP T   E +   + R +     P+ G ++KWDY+   WK+
Sbjct:   61 PAYFDRREIPLPEIKYVQELSSVQQSLKEKEKGSWTALSVDEKVALYRISFKESFAEMNKATGEWKSVVAGILFFLGFTGVVVLWQRKYVYG-ELPHTFDPEYKEKEIQRMLDMRINPIEGFSAKWDYENKAWKK 194
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Cavefish
Match: cox4i1l (cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [Source:NCBI gene;Acc:103039037])

HSP 1 Score: 72.7886 bits (177), Expect = 1.635e-15
Identity = 40/102 (39.22%), Postives = 58/102 (56.86%), Query Frame = 3 
Query:  330 EDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWK 635
            + W+ L+ EEK +LYR+S+ LT  E+  G+ EW    A +F  LG   L+  + R+Y+ G ++P TL+ E       R I     PV G A+KWDY+K  WK
Sbjct:   75 DAWTKLSKEEKLQLYRLSFELTYPEMRKGSDEWKTVLAGIFIFLGLTGLLVWWQRIYVYG-DVPHTLSPEWVEKQTQRMIDMQVNPVHGFAAKWDYEKKQWK 175
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Cavefish
Match: cox4i2 (cytochrome c oxidase subunit 4 isoform 2, mitochondrial-like [Source:NCBI gene;Acc:103036968])

HSP 1 Score: 68.9366 bits (167), Expect = 3.849e-14
Identity = 45/132 (34.09%), Postives = 63/132 (47.73%), Query Frame = 3 
Query:  243 YFDHTLFPYPAIRWQE-YDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWK 635
            YFD    P P   +Q+        LK KE   W+ L+ EEK  LYRI ++ T AE+     EW    A +   +G   L+  + R Y+  P  P +  EE +   + R +     PV G +SKWDY+K  WK
Sbjct:   45 YFDRLDTPLPDRPYQDSLSAAEKSLKQKEKGPWTSLSNEEKLALYRIMFKETYAEMKRPTGEWKTVVAGILFFMGATGLVVLWQRYYVYPPH-PPSFDEEWQAKQVKRMLDMRINPVEGFSSKWDYEKGQWK 175
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Cavefish
Match: cox4i2 (cytochrome c oxidase subunit 4 isoform 2, mitochondrial-like [Source:NCBI gene;Acc:103036968])

HSP 1 Score: 68.1662 bits (165), Expect = 1.293e-13
Identity = 45/132 (34.09%), Postives = 63/132 (47.73%), Query Frame = 3 
Query:  243 YFDHTLFPYPAIRWQE-YDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWK 635
            YFD    P P   +Q+        LK KE   W+ L+ EEK  LYRI ++ T AE+     EW    A +   +G   L+  + R Y+  P  P +  EE +   + R +     PV G +SKWDY+K  WK
Sbjct:   85 YFDRLDTPLPDRPYQDSLSAAEKSLKQKEKGPWTSLSNEEKLALYRIMFKETYAEMKRPTGEWKTVVAGILFFMGATGLVVLWQRYYVYPPH-PPSFDEEWQAKQVKRMLDMRINPVEGFSSKWDYEKGQWK 215
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Nematostella
Match: EDO45939 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRF4])

HSP 1 Score: 51.2174 bits (121), Expect = 1.989e-8
Identity = 43/144 (29.86%), Postives = 65/144 (45.14%), Query Frame = 3 
Query:  186 FPQIGNREIVGYGTSGAPDYFDHTLFPYPAIRWQEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDY 617
            F +I +R +     + AP  FD    P P  R QE+  +   LK+KE   W+ L+ E++  LY+  +  T+ E   G          V  L+  +L    ++R YI GPE P TL E+    S  +       P+TG  SK  +
Sbjct:    4 FLRISSRLVGRRIHTSAPRKFD----PVPIAR-QEFGSDLEALKAKEKGPWTALSKEDRVALYQSQFPKTLQESKLGEPYAKKVVGGVGVLISLSLAFFAFLRTYI-GPEPPPTLNEDWIRASEEKMRRQRTNPITGFTSKQQH 141
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Medaka
Match: cox4i1 (cytochrome c oxidase subunit 4 isoform 1, mitochondrial [Source:NCBI gene;Acc:101171816])

HSP 1 Score: 78.5666 bits (192), Expect = 7.844e-18
Identity = 52/164 (31.71%), Postives = 74/164 (45.12%), Query Frame = 3 
Query:  186 FPQIGNREIV-------GYGTSGA-----PDYFDHTLFPYPAIRW-QEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            F  IG R I        G+G +       P YFD    P P I + Q        LK KE   W+ L+  EK  LY +S++ + AE+  G  EW      +   +G   L+  + R Y+ GP +P TL  E +   L R +     PV G ++KWDY+   WK+
Sbjct:    7 FSLIGKRAISTSVCVRGGHGVAKVEDYTLPAYFDRRETPLPEIAYVQTLTPEQKALKEKEKGSWAALSNAEKVALYHLSFKQSFAEMNQGTGEWKSVVGGIMFFVGLTGLVVLWQRKYVYGP-VPHTLDPEYKQQELQRMLDMRMNPVEGFSAKWDYENKQWKK 169
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Medaka
Match: cox4i1 (cytochrome c oxidase subunit 4 isoform 1, mitochondrial [Source:NCBI gene;Acc:101171816])

HSP 1 Score: 78.5666 bits (192), Expect = 7.844e-18
Identity = 52/164 (31.71%), Postives = 74/164 (45.12%), Query Frame = 3 
Query:  186 FPQIGNREIV-------GYGTSGA-----PDYFDHTLFPYPAIRW-QEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKE 638
            F  IG R I        G+G +       P YFD    P P I + Q        LK KE   W+ L+  EK  LY +S++ + AE+  G  EW      +   +G   L+  + R Y+ GP +P TL  E +   L R +     PV G ++KWDY+   WK+
Sbjct:    7 FSLIGKRAISTSVCVRGGHGVAKVEDYTLPAYFDRRETPLPEIAYVQTLTPEQKALKEKEKGSWAALSNAEKVALYHLSFKQSFAEMNQGTGEWKSVVGGIMFFVGLTGLVVLWQRKYVYGP-VPHTLDPEYKQQELQRMLDMRMNPVEGFSAKWDYENKQWKK 169
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Medaka
Match: cox4i2 (cytochrome c oxidase subunit 4 isoform 2, mitochondrial [Source:NCBI gene;Acc:101172078])

HSP 1 Score: 77.411 bits (189), Expect = 2.777e-17
Identity = 46/134 (34.33%), Postives = 68/134 (50.75%), Query Frame = 3 
Query:  237 PDYFDHTLFPYPAIRWQEY-DENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWK 635
            P Y+D    P P   +++   + +  LK KE   W+ L+ EEK  LYR+ +  T  E+     EW      +F  LGF  L+  + R+Y+  P LPKT   + + + L R +     PV G A+KWDY+K  WK
Sbjct:   44 PMYYDRADVPLPDKPYKDLLTDADKSLKQKEKGPWTQLSKEEKIALYRLMFCQTYPEMKQKTSEWKTVLGGIFFFLGFTGLVVWWQRIYVY-PPLPKTFEGDSQAMQLKRMLDMRVNPVQGFAAKWDYEKGQWK 176
[Close]
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Medaka
Match: cox4i2 (cytochrome c oxidase subunit 4 isoform 2, mitochondrial [Source:NCBI gene;Acc:101172078])

HSP 1 Score: 77.7962 bits (190), Expect = 5.894e-17
Identity = 46/134 (34.33%), Postives = 68/134 (50.75%), Query Frame = 3 
Query:  237 PDYFDHTLFPYPAIRWQEY-DENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWK 635
            P Y+D    P P   +++   + +  LK KE   W+ L+ EEK  LYR+ +  T  E+     EW      +F  LGF  L+  + R+Y+  P LPKT   + + + L R +     PV G A+KWDY+K  WK
Sbjct:   92 PMYYDRADVPLPDKPYKDLLTDADKSLKQKEKGPWTQLSKEEKIALYRLMFCQTYPEMKQKTSEWKTVLGGIFFFLGFTGLVVWWQRIYVY-PPLPKTFEGDSQAMQLKRMLDMRVNPVQGFAAKWDYEKGQWK 224
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BLAST of Cytochrome c oxidase subunit 4 vs. Planmine SMEST
Match: SMESG000071294.1 (SMESG000071294.1)

HSP 1 Score: 367.466 bits (942), Expect = 5.636e-131
Identity = 179/179 (100.00%), Postives = 179/179 (100.00%), Query Frame = 3 
Query:  105 GSKPFKIIKRFRNFELSALILPAQKEYFPQIGNREIVGYGTSGAPDYFDHTLFPYPAIRWQEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKEE 641
            GSKPFKIIKRFRNFELSALILPAQKEYFPQIGNREIVGYGTSGAPDYFDHTLFPYPAIRWQEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKEE
Sbjct:    6 GSKPFKIIKRFRNFELSALILPAQKEYFPQIGNREIVGYGTSGAPDYFDHTLFPYPAIRWQEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYRLTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEEGRMISLYRKIYSSFEPVTGVASKWDYDKLMWKEE 184
The following BLAST results are available for this feature:
BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
COX4I21.906e-1838.46cytochrome c oxidase subunit 4I2 [Source:HGNC Symb... [more]
COX4I13.941e-1833.33cytochrome c oxidase subunit 4I1 [Source:HGNC Symb... [more]
COX4I13.941e-1833.33cytochrome c oxidase subunit 4I1 [Source:HGNC Symb... [more]
COX4I13.941e-1833.33cytochrome c oxidase subunit 4I1 [Source:HGNC Symb... [more]
COX4I11.411e-932.67cytochrome c oxidase subunit 4I1 [Source:HGNC Symb... [more]
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BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cox-41.681e-1933.11Cytochrome OXidase assembly protein [Source:UniPr... [more]
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BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
COX44.098e-2838.67gene:FBgn0032833 transcript:FBtr0081300[more]
COX44.098e-2838.67gene:FBgn0032833 transcript:FBtr0332243[more]
COX44.098e-2838.67gene:FBgn0032833 transcript:FBtr0081301[more]
COX44.098e-2838.67gene:FBgn0032833 transcript:FBtr0332242[more]
COX4L3.589e-2736.05gene:FBgn0033020 transcript:FBtr0335260[more]
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BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cox4i13.796e-2135.56cytochrome c oxidase subunit 4I1 [Source:ZFIN;Acc:... [more]
cox4i13.796e-2135.56cytochrome c oxidase subunit 4I1 [Source:ZFIN;Acc:... [more]
cox4i21.435e-1631.97cytochrome c oxidase subunit 4I2 [Source:ZFIN;Acc:... [more]
cox4i1l1.403e-1537.00cytochrome c oxidase subunit 4I1, like [Source:ZFI... [more]
cox4i1l1.403e-1537.00cytochrome c oxidase subunit 4I1, like [Source:ZFI... [more]
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BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
maml13.016e-1737.78mastermind like transcriptional coactivator 1 [Sou... [more]
cox4i13.987e-1631.08cytochrome c oxidase subunit IV isoform 1 [Source:... [more]
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BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cox4i11.417e-1732.59cytochrome c oxidase subunit 4I1 [Source:MGI Symbo... [more]
Cox4i11.417e-1732.59cytochrome c oxidase subunit 4I1 [Source:MGI Symbo... [more]
Cox4i28.764e-1635.90cytochrome c oxidase subunit 4I2 [Source:MGI Symbo... [more]
Cox4i28.764e-1635.90cytochrome c oxidase subunit 4I2 [Source:MGI Symbo... [more]
Cox4i11.665e-935.53cytochrome c oxidase subunit 4I1 [Source:MGI Symbo... [more]
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BLAST of Cytochrome c oxidase subunit 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O46584|COX41_AOTAZ3.276e-1934.81Cytochrome c oxidase subunit 4 isoform 1, mitochon... [more]
sp|O46578|COX41_GORGO4.828e-1833.33Cytochrome c oxidase subunit 4 isoform 1, mitochon... [more]
sp|Q96KJ9|COX42_HUMAN9.153e-1838.46Cytochrome c oxidase subunit 4 isoform 2, mitochon... [more]
sp|O46577|COX41_PANTR1.071e-1733.33Cytochrome c oxidase subunit 4 isoform 1, mitochon... [more]
sp|P13073|COX41_HUMAN1.893e-1733.33Cytochrome c oxidase subunit 4 isoform 1, mitochon... [more]
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BLAST of Cytochrome c oxidase subunit 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1I8HUC82.238e-3640.85Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8HY856.291e-3640.85Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8JKZ76.035e-3540.00Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1S3D1T51.494e-3445.28cytochrome c oxidase subunit 4 isoform 2, mitochon... [more]
Q0PWT81.086e-3345.51Cytochrome c oxidase polypeptide IV-like protein (... [more]
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BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
cox4i15.355e-2034.81cytochrome c oxidase subunit 4 isoform 1, mitochon... [more]
cox4i1l1.635e-1539.22cytochrome c oxidase subunit 4 isoform 1, mitochon... [more]
cox4i23.849e-1434.09cytochrome c oxidase subunit 4 isoform 2, mitochon... [more]
cox4i21.293e-1334.09cytochrome c oxidase subunit 4 isoform 2, mitochon... [more]
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BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO459391.989e-829.86Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Cytochrome c oxidase subunit 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
cox4i17.844e-1831.71cytochrome c oxidase subunit 4 isoform 1, mitochon... [more]
cox4i17.844e-1831.71cytochrome c oxidase subunit 4 isoform 1, mitochon... [more]
cox4i22.777e-1734.33cytochrome c oxidase subunit 4 isoform 2, mitochon... [more]
cox4i25.894e-1734.33cytochrome c oxidase subunit 4 isoform 2, mitochon... [more]
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BLAST of Cytochrome c oxidase subunit 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000071294.15.636e-131100.00SMESG000071294.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30025809 ID=SMED30025809|Name=Cytochrome c oxidase subunit 4|organism=Schmidtea mediterranea sexual|type=transcript|length=727bp
TGTATGTTCAAGCGTTAATAATATTTATATTGTTTATTTAAATTATTTAT
ATTTAGTTTTTAATATTTCTGTGAATTTTTTGAAGTATAATGATTTTAAA
ATTTGGATCTAAACCTTTTAAAATTATAAAAAGGTTCCGAAATTTTGAGC
TTTCAGCGCTTATTTTACCCGCTCAAAAGGAATATTTTCCTCAAATTGGT
AATCGGGAAATTGTTGGTTATGGAACATCTGGTGCTCCTGATTATTTTGA
TCACACATTGTTTCCATACCCTGCTATAAGATGGCAAGAATATGATGAAA
ACAATTTAAAATTAAAATCCAAGGAATGTGAAGATTGGTCATTGTTAACT
TTAGAAGAAAAAAAGAAATTATATCGAATAAGTTATCGGCTAACAATTGC
CGAATTAACGTCAGGAAATTGTGAATGGTTGTATACATGGGCATTGGTAT
TCACTCTTCTAGGATTTGCTTTACTAATGGCAACATACGTTCGATTATAT
ATTGTAGGGCCTGAGTTACCGAAAACGCTAACTGAGGAAGGAAGAATGAT
AAGTCTTTATAGAAAAATTTATAGTAGTTTTGAGCCTGTTACTGGTGTTG
CTTCGAAATGGGATTATGATAAATTGATGTGGAAAGAAGAATAATTAATG
TTAAATTTAAAATGTTTTAAAACTTAATTAAATTATTGTTTCATTTCCTA
ATATATTTAGAGGAAAATATAAGGTTG
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protein sequence of SMED30025809-orf-1

>SMED30025809-orf-1 ID=SMED30025809-orf-1|Name=SMED30025809-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=185bp
MILKFGSKPFKIIKRFRNFELSALILPAQKEYFPQIGNREIVGYGTSGAP
DYFDHTLFPYPAIRWQEYDENNLKLKSKECEDWSLLTLEEKKKLYRISYR
LTIAELTSGNCEWLYTWALVFTLLGFALLMATYVRLYIVGPELPKTLTEE
GRMISLYRKIYSSFEPVTGVASKWDYDKLMWKEE*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0022900electron transport chain
GO:1902600hydrogen ion transmembrane transport
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
Vocabulary: INTERPRO
TermDefinition
IPR036639Cyt_c_oxidase_su4_sf
IPR013288Cyt_c_oxidase_su4
IPR004203Cyt_c_oxidase_su4_fam
Vocabulary: molecular function
TermDefinition
GO:0004129cytochrome-c oxidase activity
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR013288Cytochrome c oxidase subunit IVPRINTSPR01873CYTCOXIDASE4coord: 166..182
score: 57.65
coord: 138..151
score: 36.86
coord: 53..66
score: 29.71
coord: 96..114
score: 36.63
IPR036639Cytochrome c oxidase subunit IV superfamilyGENE3DG3DSA:1.10.442.10coord: 38..183
e-value: 2.6E-38
score: 133.0
IPR036639Cytochrome c oxidase subunit IV superfamilySUPERFAMILYSSF81406Mitochondrial cytochrome c oxidase subunit IVcoord: 40..182
IPR004203Cytochrome c oxidase subunit IV familyPFAMPF02936COX4coord: 46..182
e-value: 1.8E-32
score: 112.3
IPR004203Cytochrome c oxidase subunit IV familyPANTHERPTHR10707CYTOCHROME C OXIDASE SUBUNIT IVcoord: 37..182
IPR004203Cytochrome c oxidase subunit IV familyCDDcd00922Cyt_c_Oxidase_IVcoord: 40..176
e-value: 1.33135E-33
score: 114.29
NoneNo IPR availableTMHMMTMhelixcoord: 117..139