HTH CENPB-type domain-containing protein

Overview


Name	HTH CENPB-type domain-containing protein
Smed ID	SMED30025788
Length (bp)	330

Neoblast Clusters

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Embryonic Expression

Davies et. al., 2017

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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30025788

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
whole organism	SMED30025788		Contig11372	uc_Smed_v2	PMID:27612384 Roberts-Galbraith et al., 2016
whole organism	SMED30025788		Contig11372	newmark_ests	PMID:27612384 Roberts-Galbraith et al., 2016

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Homology

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BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Human
Match: TIGD6 (tigger transposable element derived 6 [Source:HGNC Symbol;Acc:HGNC:18332])

HSP 1 Score: 73.1738 bits (178), Expect = 7.724e-16
Identity = 35/82 (42.68%), Postives = 47/82 (57.32%), Query Frame = 2

Query:   44 WNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEK-NPCEMGKFANPQCFR 286
            W+   +  LI  Y P DIFNAD+T +F +  P  TLA  G    GGK  K+R+  L  C A+GTEK  P  +G+ A+P C +
Sbjct:  158 WHAGEIIKLIADYSPDDIFNADETGVFFQLLPQHTLAAKGDHCRGGKKAKQRLTALFCCNASGTEKMRPLIVGRSASPHCLK 239

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Query:   44 WNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEK-NPCEMGKFANPQCFR 286
            W+   +  LI  Y P DIFNAD+T +F +  P  TLA  G    GGK  K+R+  L  C A+GTEK  P  +G+ A+P C +
Sbjct:  158 WHAGEIIKLIADYSPDDIFNADETGVFFQLLPQHTLAAKGDHCRGGKKAKQRLTALFCCNASGTEKMRPLIVGRSASPHCLK 239

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BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Human
Match: TIGD4 (tigger transposable element derived 4 [Source:HGNC Symbol;Acc:HGNC:18335])

HSP 1 Score: 56.225 bits (134), Expect = 6.415e-10
Identity = 28/82 (34.15%), Postives = 44/82 (53.66%), Query Frame = 2

Query:   44 WNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEKNP-CEMGKFANPQCFR 286
            W  NVLP  +  Y P ++FN  +T L  +  P+ T A  G   + GK  K+R+ +++    +G+EK P   +GK   P CF+
Sbjct:  162 WYQNVLPYYLNDYHPKNVFNIKETGLLYRMLPTNTFAFKGETCSVGKLCKDRITLVVGTNMDGSEKLPLLVIGKKRTPHCFK 243

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BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Human
Match: JRKL (JRK like [Source:HGNC Symbol;Acc:HGNC:6200])

HSP 1 Score: 48.521 bits (114), Expect = 3.174e-7
Identity = 35/108 (32.41%), Postives = 50/108 (46.30%), Query Frame = 2

Query:    8 ERAAADHTGAENWNTNVLPTL-IEGYDPSDIFNADKTSLFNKAAPSGTLAVTG-IQPTGGKTPKERMAMLLLCTANGTEK-NPCEMGKFANPQCFR---TARPPLRYF 313
            ER   D T  E++  N    +  E   P  I+NAD+T LF K  PS    + G     G K+ +ER+ ++    A G  K   C +GK   P+ F+   T   P+ YF
Sbjct:  143 ERLNGDETAVEDFCNNFRDFIERENLQPEQIYNADETGLFWKCLPSRISVIKGKCTVPGHKSIEERVTIMCCANATGLHKLKLCVVGKAKKPRSFKSTDTLNLPVSYF 250

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BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Human
Match: JRK (Jrk helix-turn-helix protein [Source:HGNC Symbol;Acc:HGNC:6199])

HSP 1 Score: 45.0542 bits (105), Expect = 5.452e-6
Identity = 30/100 (30.00%), Postives = 48/100 (48.00%), Query Frame = 2

Query:    8 ERAAADHTGAENWNTNVLPTLIE-GYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTP-----KERMAMLLLCTANGTEK-NPCEMGKFANPQCFR 286
            E+ +ADH  AE +         E G     ++NAD+T LF +  P+ T       P GG  P     K+R+ +L+   A G+ +  P  +GK + P+ F+
Sbjct:  153 EKQSADHQAAEQFCAFFRSLAAEHGLSAEQVYNADETGLFWRCLPNPT-------PEGGAVPGPKQGKDRLTVLMCANATGSHRLKPLAIGKCSGPRAFK 245

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BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000046714.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:KV460367.1:582927:585046:-1 gene:ENSXETG00000018570.1 transcript:ENSXETT00000046714.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 74.7146 bits (182), Expect = 1.902e-16
Identity = 38/95 (40.00%), Postives = 50/95 (52.63%), Query Frame = 2

Query:    5 GERAAADHTGAENWNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEK-NPCEMGKFANPQCFR 286
            GE  + D     NW TN LP  +EGY+  +IFN D+T LF    P  T    G    GGK  K R+ +L    A+G+EK  P  +GK   P+CF+
Sbjct:  141 GESKSVDIDTVTNWKTNQLPCYLEGYELKNIFNTDETGLFFNVLPGKTFCFRGEDCHGGKLSKLRLTVLFTTNADGSEKLKPLVIGKSVKPRCFK 235

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BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Xenopus
Match: kif6 (kinesin family member 6 [Source:Xenbase;Acc:XB-GENE-1014042])

HSP 1 Score: 45.4394 bits (106), Expect = 3.401e-6
Identity = 33/101 (32.67%), Postives = 51/101 (50.50%), Query Frame = 2

Query:    5 GERAAADHTGAENWNTNVLPTLI--EGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGG-KTPKERMAMLLLCTANGTEK-NPCEMGKFANPQCFRTAR 295
            GE+A+ ++  A+N+    L  L+  E      ++NA K SLF +  P   +A     P+ G + PKER+ +L    A GT K     +GK  NP+ F+  R
Sbjct:  319 GEKASEEYNVADNF-VKKLNKLVSDEHLSAEQVYNAAKASLFWRHLPQKLVATAQKPPSSGLEDPKERLTVLACSNAAGTHKARLLVIGKSRNPRAFKGVR 418

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BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Mouse
Match: Tigd4 (tigger transposable element derived 4 [Source:MGI Symbol;Acc:MGI:2685264])

HSP 1 Score: 56.9954 bits (136), Expect = 2.365e-10
Identity = 31/91 (34.07%), Postives = 48/91 (52.75%), Query Frame = 2

Query:   44 WNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEKNPCE-MGKFANPQCFRTARP-PLRY 310
            W  NVLP  +  Y P ++FN  +T L  +  P+ T A  G   + GK  K+R+ + L    +G+EK P   +GK   P+CF+  +  P+ Y
Sbjct:  162 WYQNVLPYYLNDYHPKNVFNVKETGLLYRMLPTNTFAFKGETCSVGKLCKDRITLALGTNMDGSEKLPLLIIGKNRAPRCFKGIKSLPVYY 252

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BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Mouse
Match: Jrkl (Jrk-like [Source:MGI Symbol;Acc:MGI:1924782])

HSP 1 Score: 47.7506 bits (112), Expect = 3.508e-7
Identity = 36/108 (33.33%), Postives = 48/108 (44.44%), Query Frame = 2

Query:    8 ERAAADHTGAENWNTNVLPTL-IEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCT-ANGTEK-NPCEMGKFANPQCFR---TARPPLRYF 313
            ER   D T  E++  N    +  E   P  I+NAD+T LF K  PS T  + G     G    E    ++ CT A G  K   C +GK   P+ F+   T   P+ YF
Sbjct:  143 ERLNGDETAVEDFCNNFRDFIEQENLQPEQIYNADETGLFWKCLPSRTTVIKGKCTVPGHNLGEERITVMCCTNATGLHKLKLCVVGKARKPRSFKSTDTLNLPVSYF 250

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BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Mouse
Match: Tigd2 (tigger transposable element derived 2 [Source:MGI Symbol;Acc:MGI:1915390])

HSP 1 Score: 46.595 bits (109), Expect = 1.115e-6
Identity = 35/109 (32.11%), Postives = 52/109 (47.71%), Query Frame = 2

Query:    5 GERAAADHTGAENWNTNVLPTL-IEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGG-KTPKERMAMLLLCTANGTEK-NPCEMGKFANPQCFR---TARPPLRYF 313
            G +   D T A  +  N    +  E   P  I+ AD+T LF K  P+ TLA    Q T   +T +ER+ ++    A G+ K N C +GK   P+ F+    +  P+ YF
Sbjct:  142 GTKLKGDETAASEFCGNFQEFVERENLLPEQIYGADQTGLFWKCLPTRTLAFDTDQSTCEYRTSRERIIIMCCANATGSHKLNLCVVGKAKRPRAFKGTDLSNLPVTYF 250

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BLAST of HTH CENPB-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q17RP2|TIGD6_HUMAN (Tigger transposable element-derived protein 6 OS=Homo sapiens OX=9606 GN=TIGD6 PE=2 SV=2)

HSP 1 Score: 73.1738 bits (178), Expect = 3.709e-15
Identity = 35/82 (42.68%), Postives = 47/82 (57.32%), Query Frame = 2

Query:   44 WNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEK-NPCEMGKFANPQCFR 286
            W+   +  LI  Y P DIFNAD+T +F +  P  TLA  G    GGK  K+R+  L  C A+GTEK  P  +G+ A+P C +
Sbjct:  158 WHAGEIIKLIADYSPDDIFNADETGVFFQLLPQHTLAAKGDHCRGGKKAKQRLTALFCCNASGTEKMRPLIVGRSASPHCLK 239

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BLAST of HTH CENPB-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8BUZ3|TIGD4_MOUSE (Tigger transposable element-derived protein 4 OS=Mus musculus OX=10090 GN=Tigd4 PE=2 SV=1)

HSP 1 Score: 56.9954 bits (136), Expect = 1.654e-9
Identity = 31/91 (34.07%), Postives = 48/91 (52.75%), Query Frame = 2

Query:   44 WNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEKNPCE-MGKFANPQCFRTARP-PLRY 310
            W  NVLP  +  Y P ++FN  +T L  +  P+ T A  G   + GK  K+R+ + L    +G+EK P   +GK   P+CF+  +  P+ Y
Sbjct:  162 WYQNVLPYYLNDYHPKNVFNVKETGLLYRMLPTNTFAFKGETCSVGKLCKDRITLALGTNMDGSEKLPLLIIGKNRAPRCFKGIKSLPVYY 252

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BLAST of HTH CENPB-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8IY51|TIGD4_HUMAN (Tigger transposable element-derived protein 4 OS=Homo sapiens OX=9606 GN=TIGD4 PE=1 SV=2)

HSP 1 Score: 56.225 bits (134), Expect = 3.081e-9
Identity = 28/82 (34.15%), Postives = 44/82 (53.66%), Query Frame = 2

Query:   44 WNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEKNP-CEMGKFANPQCFR 286
            W  NVLP  +  Y P ++FN  +T L  +  P+ T A  G   + GK  K+R+ +++    +G+EK P   +GK   P CF+
Sbjct:  162 WYQNVLPYYLNDYHPKNVFNIKETGLLYRMLPTNTFAFKGETCSVGKLCKDRITLVVGTNMDGSEKLPLLVIGKKRTPHCFK 243

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BLAST of HTH CENPB-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9Y4A0|JERKL_HUMAN (Jerky protein homolog-like OS=Homo sapiens OX=9606 GN=JRKL PE=2 SV=2)

HSP 1 Score: 48.521 bits (114), Expect = 1.524e-6
Identity = 35/108 (32.41%), Postives = 50/108 (46.30%), Query Frame = 2

Query:    8 ERAAADHTGAENWNTNVLPTL-IEGYDPSDIFNADKTSLFNKAAPSGTLAVTG-IQPTGGKTPKERMAMLLLCTANGTEK-NPCEMGKFANPQCFR---TARPPLRYF 313
            ER   D T  E++  N    +  E   P  I+NAD+T LF K  PS    + G     G K+ +ER+ ++    A G  K   C +GK   P+ F+   T   P+ YF
Sbjct:  143 ERLNGDETAVEDFCNNFRDFIERENLQPEQIYNADETGLFWKCLPSRISVIKGKCTVPGHKSIEERVTIMCCANATGLHKLKLCVVGKAKKPRSFKSTDTLNLPVSYF 250

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BLAST of HTH CENPB-type domain-containing protein vs. UniProt/SwissProt
Match: sp|B2RRL2|JERKL_MOUSE (Jerky protein homolog-like OS=Mus musculus OX=10090 GN=Jrkl PE=2 SV=1)

HSP 1 Score: 47.7506 bits (112), Expect = 2.453e-6
Identity = 36/108 (33.33%), Postives = 48/108 (44.44%), Query Frame = 2

Query:    8 ERAAADHTGAENWNTNVLPTL-IEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCT-ANGTEK-NPCEMGKFANPQCFR---TARPPLRYF 313
            ER   D T  E++  N    +  E   P  I+NAD+T LF K  PS T  + G     G    E    ++ CT A G  K   C +GK   P+ F+   T   P+ YF
Sbjct:  143 ERLNGDETAVEDFCNNFRDFIEQENLQPEQIYNADETGLFWKCLPSRTTVIKGKCTVPGHNLGEERITVMCCTNATGLHKLKLCVVGKARKPRSFKSTDTLNLPVSYF 250

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BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Match: A0A1I8M6J0 (HTH CENPB-type domain-containing protein OS=Musca domestica OX=7370 GN=101887926 PE=4 SV=1)

HSP 1 Score: 95.1301 bits (235), Expect = 1.983e-20
Identity = 42/103 (40.78%), Postives = 67/103 (65.05%), Query Frame = 2

Query:    5 GERAAADHTGAENWNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEKNPCEMGKFANPQCFRTARPPLRYF 313
            GE+ +AD   AE++ ++V+P +I  Y+ +DIFNAD+++LF KA P  +L   G + TG K+ KER+ +L +C A G  K    +GK  NP+C ++   PL+Y+
Sbjct:  133 GEQKSADSNAAEDFLSSVVPNIISEYEEADIFNADESALFFKALPPKSLCKQGYRNTGFKSSKERVTLLFICNATGNYKKVIVIGKAKNPRCLKSKVSPLKYY 235

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BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Match: A0A1I8M6K0 (HTH CENPB-type domain-containing protein OS=Musca domestica OX=7370 GN=101887926 PE=4 SV=1)

HSP 1 Score: 94.7449 bits (234), Expect = 2.150e-20
Identity = 42/103 (40.78%), Postives = 67/103 (65.05%), Query Frame = 2

Query:    5 GERAAADHTGAENWNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEKNPCEMGKFANPQCFRTARPPLRYF 313
            GE+ +AD   AE++ ++V+P +I  Y+ +DIFNAD+++LF KA P  +L   G + TG K+ KER+ +L +C A G  K    +GK  NP+C ++   PL+Y+
Sbjct:  133 GEQKSADSNAAEDFLSSVVPNIISEYEEADIFNADESALFFKALPPKSLCKQGYRNTGFKSSKERVTLLFICNATGNYKKVIVIGKAKNPRCLKSKVSPLKYY 235

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BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Match: A0A034WI39 (Tigger transposable element-derived protein 6 (Fragment) OS=Bactrocera dorsalis OX=27457 GN=TIGD6 PE=4 SV=1)

HSP 1 Score: 94.3597 bits (233), Expect = 3.921e-20
Identity = 44/91 (48.35%), Postives = 58/91 (63.74%), Query Frame = 2

Query:   41 NWNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEKNPCEMGKFANPQCFRTARPPLRYF 313
            N+   VL TLI+ Y+P DIFNAD++ LF KA PSGTL   G +  GGK  K R+ +L LC ++GT K    +GK  NP+CF+    PL Y+
Sbjct:  180 NYRNEVLNTLIKDYEPGDIFNADESGLFYKALPSGTLCKGGDKAVGGKAQKARLTLLFLCNSDGTFKKVFAVGKSKNPRCFKGKVVPLPYY 270

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BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Match: A0A1I8NJ69 (HTH CENPB-type domain-containing protein OS=Musca domestica OX=7370 GN=105262334 PE=4 SV=1)

HSP 1 Score: 93.5893 bits (231), Expect = 5.346e-20
Identity = 43/103 (41.75%), Postives = 62/103 (60.19%), Query Frame = 2

Query:    5 GERAAADHTGAENWNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEKNPCEMGKFANPQCFRTARPPLRYF 313
            GE+AAAD+  A  W  + LP LI+   P  ++NAD+  LF KA P+GT A  G    GGK  K R+ +L LC ++G++K+   +GK  NP C R    P++Y+
Sbjct:  139 GEKAAADYGAAGVWTKSTLPNLIKNLSPDQVYNADEAGLFYKALPTGTYASKGESVFGGKISKLRLTLLFLCNSDGSDKHVYVIGKANNPHCCRGKTMPIKYY 241

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BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Match: A0A182H7K9 (HTH CENPB-type domain-containing protein OS=Aedes albopictus OX=7160 GN=RP20_CCG023449 PE=4 SV=1)

HSP 1 Score: 87.0409 bits (214), Expect = 1.086e-18
Identity = 43/104 (41.35%), Postives = 60/104 (57.69%), Query Frame = 2

Query:    5 GERAAADHTGAENWNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEKNPC-EMGKFANPQCFRTARP-PLRY 310
            GE A+ D    ++W  N+LP +IE YDP DIFNAD+T LF K  P  T A+      GGK  K+R+ ++     +G+EK P   +GK   P+CF+  R  P+ Y
Sbjct:  112 GESASVDTVMTDDWKVNMLPKIIEDYDPRDIFNADETGLFYKCLPDKTFALQDESCHGGKYSKQRLTVMCATNMDGSEKLPLFVIGKSMKPRCFKNVRSLPVVY 215

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BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004617.1 (pep scaffold:Pmarinus_7.0:GL477874:26927:28564:-1 gene:ENSPMAG00000004208.1 transcript:ENSPMAT00000004617.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 43.5134 bits (101), Expect = 1.881e-6
Identity = 24/57 (42.11%), Postives = 34/57 (59.65%), Query Frame = 2

Query:   74 EGYDPSDIFNADKTSLFNKAAPSGTLAVTG-IQPTGGKTPKERMAMLLLCTANGTEK 241
            +G   S I+NAD+T LF K+ PS TLA +  +   G K  KE M +L+   A+GT +
Sbjct:  174 KGLCASQIYNADETGLFWKSLPSKTLASSSEVNAAGYKCSKEGMTVLMCANASGTHR 230

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BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005656.1 (pep scaffold:Pmarinus_7.0:GL476578:539135:542172:1 gene:ENSPMAG00000005132.1 transcript:ENSPMAT00000005656.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 42.3578 bits (98), Expect = 4.783e-6
Identity = 30/79 (37.97%), Postives = 42/79 (53.16%), Query Frame = 2

Query:    5 GERAAADHTGAENWNTNVLPTLIEG--YDPSDIFNADKTSLFNKAAPSGT-LAVTGIQPTGGKTPKERMAMLLLCTANG 232
            GE A AD   AE + +  L  +IEG  Y P  +FN ++T LF K  P+ T L+       G K  K+R+A+L+   A G
Sbjct:  153 GETAGADVEAAEAFKS-TLKEIIEGGGYSPEQVFNVNETGLFWKRMPASTFLSREEKTAPGFKASKDRLALLVGANAAG 230

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BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010132.1 (pep scaffold:Pmarinus_7.0:GL477949:48477:51271:1 gene:ENSPMAG00000009170.1 transcript:ENSPMAT00000010132.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 41.9726 bits (97), Expect = 6.580e-6
Identity = 32/79 (40.51%), Postives = 42/79 (53.16%), Query Frame = 2

Query:    5 GERAAADHTGAENWNTNVLPTLIEG--YDPSDIFNADKTSLFNKAAPSGT-LAVTGIQPTGGKTPKERMAMLLLCTANG 232
            GE A AD   AE + +  L  +IEG  Y P  +FN ++T LF K  P+ T L+       G K  K+R+A  LL  ANG
Sbjct:  150 GETAGADVEAAEAFKS-TLKEIIEGGGYSPEQVFNVNETRLFWKRMPASTFLSREKKTAPGFKASKDRLA--LLVGANG 225

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001313.1 (pep scaffold:Pmarinus_7.0:GL487606:277:3092:-1 gene:ENSPMAG00000001181.1 transcript:ENSPMAT00000001313.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 41.9726 bits (97), Expect = 6.647e-6
Identity = 32/79 (40.51%), Postives = 42/79 (53.16%), Query Frame = 2

Query:    5 GERAAADHTGAENWNTNVLPTLIEG--YDPSDIFNADKTSLFNKAAPSGT-LAVTGIQPTGGKTPKERMAMLLLCTANG 232
            GE A AD   AE + +  L  +IEG  Y P  +FN ++T LF K  P+ T L+       G K  K+R+A  LL  ANG
Sbjct:  151 GETAGADVEAAEAFKST-LKEIIEGGGYSPEQVFNVNETRLFWKRMPASTFLSREKKTAPGFKASKDRLA--LLVGANG 226

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BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Nematostella
Match: EDO40000 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S8J7])

HSP 1 Score: 54.6842 bits (130), Expect = 2.947e-10
Identity = 31/91 (34.07%), Postives = 46/91 (50.55%), Query Frame = 2

Query:   41 NWNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEKNPCEMGKFANPQCFRTAR-PPLRY 310
            +W  + LPTL+  Y   D+F+AD+  LF KA P   + +      GGK  K R+  L   +++G +     +GK   P+CF   R  P RY
Sbjct:  109 SWEESTLPTLLSKYALEDMFDADEFGLFYKALPDKLMHLKLQSCVGGKQSKVRLTGLAAASSSGEKLPMFVIGKSQKPRCFSGVRNLPCRY 199

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Nematostella
Match: EDO44738 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUQ6])

HSP 1 Score: 46.595 bits (109), Expect = 2.607e-7
Identity = 25/80 (31.25%), Postives = 39/80 (48.75%), Query Frame = 2

Query:   44 WNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEKNPCEMGKFANPQCF 283
            W   ++  + +GY  +DI+N  +T L+ +A P   L      P    T  ER+ + L C  +G  + P  +G  ANP CF
Sbjct:  147 WTEKIME-VTDGYRSTDIYNLVETGLYYRALPDKNLV-----PETESTSTERLTVTLCCNMDGEFEKPLVIGPTANPPCF 220

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST
Match: SMESG000079212.1 (SMESG000079212.1)

HSP 1 Score: 50.0618 bits (118), Expect = 3.474e-8
Identity = 23/54 (42.59%), Postives = 33/54 (61.11%), Query Frame = 2

Query:    5 GERAAADHTGAENWNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGI 166
            G+ A AD T A +   N+L  L++ YD +DIFN D+++LF K  P  TL   G+
Sbjct:   70 GDSAEADQTTASSCINNILQPLLQKYDGNDIFNGDESALFFKCFPGNTLVFKGV 123

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST
Match: SMESG000029226.1 (SMESG000029226.1)

HSP 1 Score: 48.9062 bits (115), Expect = 8.838e-8
Identity = 28/95 (29.47%), Postives = 47/95 (49.47%), Query Frame = 2

Query:    5 GERAAADHTGAENWNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEK-NPCEMGKFANPQCFR 286
            GE A  + +  E W +  L  + + +   DI  A++T L  K  P+ T  +   +   G+  KER+ +L  C A G++K  P  +GK   P+C +
Sbjct: 2081 GESAKVNESTVEEWLSK-LSNITKDFKFEDIDKAEETGLLYKCLPNKTFNIKDEKCFNGEKSKERITILFGCDAAGSDKLTPLVIGKSLKPRCIK 2174

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST
Match: SMESG000029226.1 (SMESG000029226.1)

HSP 1 Score: 48.9062 bits (115), Expect = 8.843e-8
Identity = 28/95 (29.47%), Postives = 47/95 (49.47%), Query Frame = 2

Query:    5 GERAAADHTGAENWNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEK-NPCEMGKFANPQCFR 286
            GE A  + +  E W +  L  + + +   DI  A++T L  K  P+ T  +   +   G+  KER+ +L  C A G++K  P  +GK   P+C +
Sbjct: 2143 GESAKVNESTVEEWLSK-LSNITKDFKFEDIDKAEETGLLYKCLPNKTFNIKDEKCFNGEKSKERITILFGCDAAGSDKLTPLVIGKSLKPRCIK 2236

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST
Match: SMESG000029226.1 (SMESG000029226.1)

HSP 1 Score: 48.9062 bits (115), Expect = 8.851e-8
Identity = 28/95 (29.47%), Postives = 47/95 (49.47%), Query Frame = 2

Query:    5 GERAAADHTGAENWNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEK-NPCEMGKFANPQCFR 286
            GE A  + +  E W +  L  + + +   DI  A++T L  K  P+ T  +   +   G+  KER+ +L  C A G++K  P  +GK   P+C +
Sbjct: 2236 GESAKVNESTVEEWLSK-LSNITKDFKFEDIDKAEETGLLYKCLPNKTFNIKDEKCFNGEKSKERITILFGCDAAGSDKLTPLVIGKSLKPRCIK 2329

[Close]

BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST
Match: SMESG000029226.1 (SMESG000029226.1)

HSP 1 Score: 48.9062 bits (115), Expect = 8.856e-8
Identity = 28/95 (29.47%), Postives = 47/95 (49.47%), Query Frame = 2

Query:    5 GERAAADHTGAENWNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTLAVTGIQPTGGKTPKERMAMLLLCTANGTEK-NPCEMGKFANPQCFR 286
            GE A  + +  E W +  L  + + +   DI  A++T L  K  P+ T  +   +   G+  KER+ +L  C A G++K  P  +GK   P+C +
Sbjct: 2304 GESAKVNESTVEEWLSK-LSNITKDFKFEDIDKAEETGLLYKCLPNKTFNIKDEKCFNGEKSKERITILFGCDAAGSDKLTPLVIGKSLKPRCIK 2397

The following BLAST results are available for this feature:

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Human
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Celegans
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Fly
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Zebrafish
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Xenopus
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Mouse
BLAST of HTH CENPB-type domain-containing protein vs. UniProt/SwissProt
BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Cavefish
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Sea Lamprey
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Yeast
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Nematostella
BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Medaka
BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
TIGD6	7.724e-16	42.68	tigger transposable element derived 6 [Source:HGNC...	[more]
TIGD6	7.724e-16	42.68	tigger transposable element derived 6 [Source:HGNC...	[more]
TIGD4	6.415e-10	34.15	tigger transposable element derived 4 [Source:HGNC...	[more]
JRKL	3.174e-7	32.41	JRK like [Source:HGNC Symbol;Acc:HGNC:6200]	[more]
JRK	5.452e-6	30.00	Jrk helix-turn-helix protein [Source:HGNC Symbol;A...	[more]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSXETT00000046714.1	1.902e-16	40.00	pep primary_assembly:Xenopus_tropicalis_v9.1:KV460...	[more]
kif6	3.401e-6	32.67	kinesin family member 6 [Source:Xenbase;Acc:XB-GEN...	[more]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3


Match Name	E-value	Identity	Description
Tigd4	2.365e-10	34.07	tigger transposable element derived 4 [Source:MGI ...	[more]
Jrkl	3.508e-7	33.33	Jrk-like [Source:MGI Symbol;Acc:MGI:1924782]	[more]
Tigd2	1.115e-6	32.11	tigger transposable element derived 2 [Source:MGI ...	[more]

BLAST of HTH CENPB-type domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q17RP2\|TIGD6_HUMAN	3.709e-15	42.68	Tigger transposable element-derived protein 6 OS=H...	[more]
sp\|Q8BUZ3\|TIGD4_MOUSE	1.654e-9	34.07	Tigger transposable element-derived protein 4 OS=M...	[more]
sp\|Q8IY51\|TIGD4_HUMAN	3.081e-9	34.15	Tigger transposable element-derived protein 4 OS=H...	[more]
sp\|Q9Y4A0\|JERKL_HUMAN	1.524e-6	32.41	Jerky protein homolog-like OS=Homo sapiens OX=9606...	[more]
sp\|B2RRL2\|JERKL_MOUSE	2.453e-6	33.33	Jerky protein homolog-like OS=Mus musculus OX=1009...	[more]

BLAST of HTH CENPB-type domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1I8M6J0	1.983e-20	40.78	HTH CENPB-type domain-containing protein OS=Musca ...	[more]
A0A1I8M6K0	2.150e-20	40.78	HTH CENPB-type domain-containing protein OS=Musca ...	[more]
A0A034WI39	3.921e-20	48.35	Tigger transposable element-derived protein 6 (Fra...	[more]
A0A1I8NJ69	5.346e-20	41.75	HTH CENPB-type domain-containing protein OS=Musca ...	[more]
A0A182H7K9	1.086e-18	41.35	HTH CENPB-type domain-containing protein OS=Aedes ...	[more]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4


Match Name	E-value	Identity	Description
ENSPMAT00000004617.1	1.881e-6	42.11	pep scaffold:Pmarinus_7.0:GL477874:26927:28564:-1 ...	[more]
ENSPMAT00000005656.1	4.783e-6	37.97	pep scaffold:Pmarinus_7.0:GL476578:539135:542172:1...	[more]
ENSPMAT00000010132.1	6.580e-6	40.51	pep scaffold:Pmarinus_7.0:GL477949:48477:51271:1 g...	[more]
ENSPMAT00000001313.1	6.647e-6	40.51	pep scaffold:Pmarinus_7.0:GL487606:277:3092:-1 gen...	[more]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO40000	2.947e-10	34.07	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO44738	2.607e-7	31.25	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of HTH CENPB-type domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of HTH CENPB-type domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000079212.1	3.474e-8	42.59	SMESG000079212.1	[more]
SMESG000029226.1	8.838e-8	29.47	SMESG000029226.1	[more]
SMESG000029226.1	8.843e-8	29.47	SMESG000029226.1	[more]
SMESG000029226.1	8.851e-8	29.47	SMESG000029226.1	[more]
SMESG000029226.1	8.856e-8	29.47	SMESG000029226.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30025788 ID=SMED30025788|Name=HTH CENPB-type domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=330bp
TGGCGGTGAAAGAGCTGCTGCAGATCATACCGGTGCCGAAAATTGGAATA
CCAACGTCTTGCCCACCTTGATTGAAGGGTATGATCCATCCGATATCTTT
AATGCTGACAAAACAAGCTTATTCAACAAAGCGGCGCCCTCTGGCACATT
AGCTGTCACTGGTATTCAACCAACTGGTGGAAAGACACCGAAAGAACGAA
TGGCTATGCTTCTTCTCTGCACCGCTAATGGTACCGAAAAGAATCCATGC
GAAATGGGGAAATTTGCAAATCCACAGTGCTTTCGAACTGCTCGACCGCC
TTTGCGGTATTTCAGGTGCAGCAACGTTTT

protein sequence of SMED30025788-orf-1

>SMED30025788-orf-1 ID=SMED30025788-orf-1|Name=SMED30025788-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=109bp
GGERAAADHTGAENWNTNVLPTLIEGYDPSDIFNADKTSLFNKAAPSGTL
AVTGIQPTGGKTPKERMAMLLLCTANGTEKNPCEMGKFANPQCFRTARPP
LRYFRCSNV

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000136	whole organism

Vocabulary: **molecular function**
Term	Definition
GO:0003676	nucleic acid binding
GO:0003677	DNA binding

Main menu

HTH CENPB-type domain-containing protein

Zeng et. al., 2018

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Owlery

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