NADPH--cytochrome P450 reductase

Query:  312 TQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSE--TPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            T S     F+EKM K G+N++VFYGSQTGTAE+FANRL+K+A RYG++GM+ADPEE D+ +L +L  I+N+L +FCMATYGEGDPTDNAQ+FY+WLQ   V+++G+++ VFGLGNKTYE+FNAMGKY D+RL +LGA RI ELG+GDDD N+E+ FITW+E  W +VC HFG+     + ++RQY L +  ++   K+Y GE+ RL ++E Q+PPFDAKNPFLA V   ++L +G +R +MH+ELDI++S+I+YESGDHVAV+P ND  LV++L K L  +LD V+S+  +DE+++K+HPFPCPT+YRTAL +Y+DI NP +TNVL +L++YA++ SE + L+ +  SS EGK  Y  W++++RR+ILA+L+D PSL+ P DHL ELLPRLQ RYYSI+SS K++PN++HI AV+++Y T  GR  KGV T++L  K P+       +VP++VR+SQFRLP+K+ +P+IMVGPG+G+APF GFI++R+  +  GK +GET++Y+GCR+  ED+LY +EL + H+D  ++ L +AFSR+QS K+YVQHL+  +++R+ +W +I  G H Y+CGDA++MA+DV NT  +I    G M ++QA DY+K +  KGR+S DVWS
Sbjct:   64 TSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLL--KQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTKGRYSLDVWS 680          

Query:  312 TQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSE--TPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICG 2015
            T S     F+EKM K G+N++VFYGSQTGTAE+FANRL+K+A RYG++GM+ADPEE D+ +L +L  I+N+L +FCMATYGEGDPTDNAQ+FY+WLQ   V+++G+++ VFGLGNKTYE+FNAMGKY D+RL +LGA RI ELG+GDDD N+E+ FITW+E  W +VC HFG+     + ++RQY L +  ++   K+Y GE+ RL ++E Q+PPFDAKNPFLA V   ++L +G +R +MH+ELDI++S+I+YESGDHVAV+P ND  LV++L K L  +LD V+S+  +DE+++K+HPFPCPT+YRTAL +Y+DI NP +TNVL +L++YA++ SE + L+ +  SS EGK  Y  W++++RR+ILA+L+D PSL+ P DHL ELLPRLQ RYYSI+SS K++PN++HI AV+++Y T  GR  KGV T++L  K P+       +VP++VR+SQFRLP+K+ +P+IMVGPG+G+APF GFI++R+  +  GK +GET++Y+GCR+  ED+LY +EL + H+D  ++ L +AFSR+QS K+YVQHL+  +++R+ +W +I  G H Y+CG
Sbjct:   64 TSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLL--KQDREHLWKLIEGGAHIYVCG 633          

Query:  600 QNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSE--TPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICG 2015
            Q+A   +   R  VFGLGNKTYE+FNAMGKY D+RL +LGA RI ELG+GDDD N+E+ FITW+E  W +VC HFG+     + ++RQY L +  ++   K+Y GE+ RL ++E Q+PPFDAKNPFLA V   ++L +G +R +MH+ELDI++S+I+YESGDHVAV+P ND  LV++L K L  +LD V+S+  +DE+++K+HPFPCPT+YRTAL +Y+DI NP +TNVL +L++YA++ SE + L+ +  SS EGK  Y  W++++RR+ILA+L+D PSL+ P DHL ELLPRLQ RYYSI+SS K++PN++HI AV+++Y T  GR  KGV T++L  K P+       +VP++VR+SQFRLP+K+ +P+IMVGPG+G+APF GFI++R+  +  GK +GET++Y+GCR+  ED+LY +EL + H+D  ++ L +AFSR+QS K+YVQHL+  +++R+ +W +I  G H Y+CG
Sbjct:  211 QSAPGGIGCWRLKVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLL--KQDREHLWKLIEGGAHIYVCG 684          

Query:  312 TQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTV 641
            T S     F+EKM K G+N++VFYGSQTGTAE+FANRL+K+A RYG++GM+ADPEE D+ +L +L  I+N+L +FCMATYGEGDPTDNAQ+FY+WLQ   V+++G+++ V
Sbjct:   37 TSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKFAV 146          

Query:  912 GEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSE--TPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            GE+ RL ++E Q+PPFDAKNPFLA V   ++L +G +R +MH+ELDI++S+I+YESGDHVAV+P ND  LV++L K L  +LD V+S+  +DE+++K+HPFPCPT+YRTAL +Y+DI NP +TNVL +L++YA++ SE + L+ +  SS EGK  Y  W++++RR+ILA+L+D PSL+ P DHL ELLPRLQ RYYSI+SS K++PN++HI AV+++Y T  GR  KGV T++L  K P+       +VP++VR+SQFRLP+K+ +P+IMVGPG+G+APF GFI++R+  +  GK +GET++Y+GCR+  ED+LY +EL + H+D  ++ L +AFSR+QS K+YVQHL+  +++R+ +W +I  G H Y+CGDA++MA+DV NT  +I    G M ++QA DY+K +  KGR+S DVWS
Sbjct:    2 GEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLL--KQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTKGRYSLDVWS 418          

Query:  366 NVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGL---RYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNI-EDHFI-TWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVP-----------ENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGD-RSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLP--SLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPV-VPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIIN-SGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
             ++V +GSQTGTA+D + RL +EA R  L       +  D   ++NL  I   L IF  AT G+GDP DN + F+ ++    +    L    + V GLG+ +Y  FN + K   RRL +LG + +  + +GDD   +  D  +  W  D+W  V    G+      +       E+P  VP           E      E  R+     Q PP ++K PFLA ++  Q +      + V  IE DI  S I + +GD V + P+N    V +  + L ++ DQ+  +   + D S     P P + R  + HY+DI +  + +    L+  +  + E + L   SS +G+ +  E+    RR IL VL D P  +  +P D+LL+L+P ++ R +SI+SS   +P+ + I   ++ + T      +G+C+ +L   +  P + PV VP++VR      P    +P+IMVGPG+G+APF+  I++R      G       ++FGCR + +DF +E E ++  + + ++ L  AFSR+Q  K+YVQH + +  +   +W++++  G +FY+ G+AK M  DV+  L++IFQ EGG+ +  A  YL  +Q   R  ++ W+
Sbjct:    5 QLLVLFGSQTGTAQDVSERLGREARRRRLGCRV---QALDSYPVVNL--INEPLVIFVCATTGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRDLWDRV---LGLYPPPPGLT------EIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESK-PFLAPMISNQRVTGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSSWLASLD--PGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN-----FLFFGCRWRDQDFYWEAEWQELEKRDCLT-LIPAFSREQEQKVYVQHRLRELGSL--VWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA 597          

Query:  300 AKLTTQSSLSGG---FIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENK-IYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQEL-CKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSI--EGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            A +TT ++ S     FI++M    + V++ YGSQTGTAE+ + RLAK+  RY  K +  DPE+ + E+L  L  +E++L + C+ATYGEGDPTDNA     +L     +++G+R+ VFGLGNKTYE+FN +G   D++L +LGA RI  LG+GDDD+N+E+ F+ W+E     V   FG   +     +RQY+LE    V E K ++KGE  RLGA+E+ RPPFD KNP+LA V +  EL  +  DRS  HIE  +  SRI+YE+GDH+AVFPTNDP+LVD+L   L  + D    +V +DED SKRHPFPCPTT+RTAL HY+DI  P+K++VL  +SEY TD +E +FL  LS+   EG  +Y  +I+  RR+I+ VL D  + K P ++LLELLPRLQ RYYSI+SSP++    I I AV+  Y     R++ GVCT YL  K+         P++VR+S  RLP+++ + +IM+GPG+G APF+GF++DR   K+AGK +G   +Y+GCR    D++Y+DEL K  +D V++ L  AFSR Q  KIYVQ  + + ++R  IWD IN G H YICGDA++MA+DV  TL  IF+  GG + ++A  Y K M+   R+ +DVWS
Sbjct:   47 ASVTTSAAASKSNQSFIDRMKNENRQVLIMYGSQTGTAEEMSGRLAKDLTRYTKKAVVVDPEDIECEDLNRLSEVEDALLVLCIATYGEGDPTDNAVTLVEYLNAGDCDLSGVRFAVFGLGNKTYEHFNEIGIQMDKQLEKLGAKRIFHLGLGDDDANLEEDFMIWREAFLPKVAEEFGWELNTEAETMRQYQLE---PVEEGKALFKGEFGRLGAYERPRPPFDVKNPYLATVAINDELHTEHSDRSCRHIEFSVEGSRIRYEAGDHLAVFPTNDPVLVDRLINMLQFDPDHAFRLVNVDEDASKRHPFPCPTTFRTALSHYVDICAPVKSHVLKAISEYCTDDTEKEFLNKLSTANEEGLKEYARYIVKERRSIVDVLTDQKTCKPPIEYLLELLPRLQARYYSIASSPRLNEEKIAICAVVTKYSIG-DRDINGVCTRYLTTKDAGSKS----PVFVRKSTMRLPHRTTTQVIMIGPGTGFAPFRGFLQDRQFHKNAGKEIGAMHLYYGCRHPDHDYIYKDELAKFQEDEVLTHLVCAFSRAQEHKIYVQDRLWETRDR--IWDAINVGAHVYICGDARNMARDVQATLQKIFREIGGKSETEAVAYFKDMEKTKRYQADVWS 662          

Query:  300 AKLTTQSSLSGG---FIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENK-IYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQEL-CKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSI--EGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            A +TT ++ S     FI++M    + V++ YGSQTGTAE+ + RLAK+  RY  K +  DPE+ + E+L  L  +E++L + C+ATYGEGDPTDNA     +L     +++G+R+ VFGLGNKTYE+FN +G   D++L +LGA RI  LG+GDDD+N+E+ F+ W+E     V   FG   +     +RQY+LE    V E K ++KGE  RLGA+E+ RPPFD KNP+LA V +  EL  +  DRS  HIE  +  SRI+YE+GDH+AVFPTNDP+LVD+L   L  + D    +V +DED SKRHPFPCPTT+RTAL HY+DI  P+K++VL  +SEY TD +E +FL  LS+   EG  +Y  +I+  RR+I+ VL D  + K P ++LLELLPRLQ RYYSI+SSP++    I I AV+  Y     R++ GVCT YL  K+         P++VR+S  RLP+++ + +IM+GPG+G APF+GF++DR   K+AGK +G   +Y+GCR    D++Y+DEL K  +D V++ L  AFSR Q  KIYVQ  + + ++R  IWD IN G H YICGDA++MA+DV  TL  IF+  GG + ++A  Y K M+   R+ +DVWS
Sbjct:   47 ASVTTSAAASKSNQSFIDRMKNENRQVLIMYGSQTGTAEEMSGRLAKDLTRYTKKAVVVDPEDIECEDLNRLSEVEDALLVLCIATYGEGDPTDNAVTLVEYLNAGDCDLSGVRFAVFGLGNKTYEHFNEIGIQMDKQLEKLGAKRIFHLGLGDDDANLEEDFMIWREAFLPKVAEEFGWELNTEAETMRQYQLE---PVEEGKALFKGEFGRLGAYERPRPPFDVKNPYLATVAINDELHTEHSDRSCRHIEFSVEGSRIRYEAGDHLAVFPTNDPVLVDRLINMLQFDPDHAFRLVNVDEDASKRHPFPCPTTFRTALSHYVDICAPVKSHVLKAISEYCTDDTEKEFLNKLSTANEEGLKEYARYIVKERRSIVDVLTDQKTCKPPIEYLLELLPRLQARYYSIASSPRLNEEKIAICAVVTKYSIG-DRDINGVCTRYLTTKDAGSKS----PVFVRKSTMRLPHRTTTQVIMIGPGTGFAPFRGFLQDRQFHKNAGKEIGAMHLYYGCRHPDHDYIYKDELAKFQEDEVLTHLVCAFSRAQEHKIYVQDRLWETRDR--IWDAINVGAHVYICGDARNMARDVQATLQKIFREIGGKSETEAVAYFKDMEKTKRYQADVWS 662          

Query:  366 NVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYT---VFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDD--DSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYR---LELPANVPENKIYKGEVTRLGA---------FEKQRPPFDAKNPFLAKVLVKQELCKG---GDRSVMHIEL-DITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDN--SKRHP------FPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDL--PSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRD-QSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            ++ + YGS+TGTA+D A  L +EA +  L+    + +E D+ +L   K +     +F ++T G+G+   N ++ +  L   ++  + L+     V GLG+ +Y+ +N  GK   RRL +LGA  +  + + DD  +  I+  FI WK + W  +         +I  N+  YR    E+  +V     Y+     LG           E   P  +  + F  KVL  + L       D  ++  E+ D   S++ ++ GD + V P N    V    + L +  +Q+   + I +++  SK  P      F   TT  T L  Y D+    K +    L  Y+T+  E + L+ L+S EG   Y ++   SRR     L D    S  +  D+L E+L  ++ R +SI+S+P  +   + +  V  +Y +      +G+C+ +++   P       V   +R   F+ P   ++P+I +GPG+G+APF+     RS+  SA  P    +++FGCR +  D+ + DE  +     VI     AFSRD    K+YVQH M   +N  +I  +++ G   +I G +  M K V+  L  I          Q  ++ +  +  G+   + WS
Sbjct:    2 SIAILYGSETGTAQDIAESLRREAQQRHLQARVHELDEYDVSQLPMEKVV-----LFVVSTTGQGEMPPNMRKTWKLLLRKSLGADFLKNVNIGVLGLGDSSYQKYNFAGKKLYRRLVQLGAKMMCGVHLADDQHEIGIDGAFIPWKTECWKKI--------KEIAENLSIYREMTAEIDTSVQITTKYR--FLELGGESGNDDDDSDEDLEPQIEIPDYFPLKVLKNRRLTSAEHFQDTRLVDFEISDRNRSKMGFQPGDVLMVRPYNPEETVKIAIEALGLTEEQLKKPLKIVKNDRFSKNPPNFLVGNFSAKTTLLTCLQRYFDLQQVPKRSFFEMLGYYSTNPPEKERLQELASPEGLDDYLDYANRSRRTTAEALRDFVATSKNLKPDYLFEILTTIRPRAFSIASAPSPFHLELLVAKV--EYKSRMADKRRGLCSTFISRLKPGDE----VFCKIRPGTFKFP-SPEAPVICIGPGTGVAPFRSLFGHRSLF-SAHFP---GILFFGCRSEHHDYYFSDEWPELSGVAVIP----AFSRDTDGRKVYVQHKMG--ENAGKIKRMLDLGAQVFIAGSSGDMPKAVSAVLAQI----------QGDEWTRRAEETGKIQYETWS 588          

Query:  366 NVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYT---VFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDD--DSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYR---LELPANVPENKIYKGEVTRLGA---------FEKQRPPFDAKNPFLAKVLVKQELCKG---GDRSVMHIEL-DITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDN--SKRHP---FPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDL--PSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRD-QSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            ++ + YGS+TGTA+D A  L +EA +  L+    + +E D+ +L   K +     +F ++T G+G+   N ++ +  L   ++  + L+     V GLG+ +Y+ +N  GK   RRL +LGA  +  + + DD  +  I+  FI WK + W  +         +I  N+  YR    E+  +V     Y+     LG           E   P  +  + F  KVL  + L       D  ++  E+ D   S++ ++ GD + V P N    V    + L +  +Q+   + I +++  SK  P       TT  T L  Y D+    K +    L  Y+T+  E + L+ L+S EG   Y ++   SRR     L D    S  +  D+L E+L  ++ R +SI+S+P  +   + +  V  +Y +      +G+C+ +++   P       V   +R   F+ P   ++P+I +GPG+G+APF+     RS+  SA  P    +++FGCR +  D+ + DE  +     VI     AFSRD    K+YVQH M   +N  +I  +++ G   +I G +  M K V+  L  I          Q  ++ +  +  G+   + WS
Sbjct:    2 SIAILYGSETGTAQDIAESLRREAQQRHLQARVHELDEYDVSQLPMEKVV-----LFVVSTTGQGEMPPNMRKTWKLLLRKSLGADFLKNVNIGVLGLGDSSYQKYNFAGKKLYRRLVQLGAKMMCGVHLADDQHEIGIDGAFIPWKTECWKKI--------KEIAENLSIYREMTAEIDTSVQITTKYR--FLELGGESGNDDDDSDEDLEPQIEIPDYFPLKVLKNRRLTSAEHFQDTRLVDFEISDRNRSKMGFQPGDVLMVRPYNPEETVKIAIEALGLTEEQLKKPLKIVKNDRFSKNPPNFLVGTKTTLLTCLQRYFDLQQVPKRSFFEMLGYYSTNPPEKERLQELASPEGLDDYLDYANRSRRTTAEALRDFVATSKNLKPDYLFEILTTIRPRAFSIASAPSPFHLELLVAKV--EYKSRMADKRRGLCSTFISRLKPGDE----VFCKIRPGTFKFP-SPEAPVICIGPGTGVAPFRSLFGHRSLF-SAHFP---GILFFGCRSEHHDYYFSDEWPELSGVAVIP----AFSRDTDGRKVYVQHKMG--ENAGKIKRMLDLGAQVFIAGSSGDMPKAVSAVLAQI----------QGDEWTRRAEETGKIQYETWS 585          

Query: 1224 TTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGR--NMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLP-------YKSKSPIIMVGPGSGIAPFKGFIE-DRSVAKSAGKPLGET--VMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVW 2153
            TT R      +DI       ++  L+E  +D +E   L  L S +G   + +++     ++  +L   P++K P D L+ELLPRL  R YS+SS        I+     +++    GR  + KG+ T +LN          V  +    ++FRLP          K P++MVGPG+G++ F  F+   R + + +     +   V++FGCR  S D +Y  EL+    + +++DL +  S  + ++  VQ  + K  ++   +   ++    +ICGDAK M+KDV     +I  ++ G+ + +A+  L  ++   ++  DVW
Sbjct:  368 TTLRHMFTTCLDIRRAPGRPLIRVLAESTSDPNEKRRLLELCSAQGMKDFTDFVRTPGLSLADMLFAFPNVKPPVDRLIELLPRLIPRPYSMSSYENRKARLIYSE---MEFPATDGRRHSRKGLATDWLNSLRIGDK---VQVLGKEPARFRLPPLGMTKNSAGKLPLLMVGPGTGVSVFLSFLHFLRKLKQDSPSDFVDVPRVLFFGCRDSSVDAIYMSELEMFVSEGILTDLIICESEQKGER--VQDGLRKYLDKVLPFLTASTESKIFICGDAKGMSKDVWQCFSDIVASDQGIPDLEAKKKLMDLKKSDQYIEDVW 681          

Query:  366 NVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVN---MNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLEL 878
            + ++ +GSQTG AE  A  L ++A   GL       +E + +  LN    E  L    +++ G+GD  DN   F   +   ++    +  L Y + GLG+  Y ++  + +  D++L+ LGA R+ +    DD   +E     W E  + ++ + F IS DK++       L+L
Sbjct:    3 DFLIAFGSQTGQAETIAKSLKEKAELIGLTPRLHALDENEKKFNLN----EEKLCAIVVSSTGDGDAPDNCARFVRRINRNSLENEYLKNLDYVLLGLGDSNYSSYQTIPRKIDKQLTALGANRLFDRAEADDQVGLELEVEPWIEKFFATLASRFDISADKMNAITESSNLKL 172          

Query:  243 KSKTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSI--EGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSG-GHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            +S+ +EE  + ++++   P  + T S+    FI+K+   G+++VVFYGSQTGT E+FA RLAKE +RY LKGM ADPEECDMEELL LK I+NSLA+FC+ATYGEGDPTDNA EFY W+ +  V+++GL Y VFGLGNKTYE++N +  Y D+RL ELGA R+ ELG+GDDD+NIED FITWK+  W +VC+HFGI G   ++ +RQYRL    +V  ++IY GE+ RL + + QRPPFDAKNPFLA + V +EL KGG RS MHIEL I  S+++Y++GDHVA+FP ND  LV+KL +  N +LD V S++  D D+SK+HPFPCPTTYRTAL HY++I    +T++L +L+EY TD+ E + L++++SI  EGK KYQ WI D+ RNI+ +LED+ S + P DH+ ELLPRLQ RYYSISSS K++P  +H+TAVL++Y T TGR  KGV T YL  K P  SE   VP+++R+SQFRLP K ++PIIMVGPG+G+APF+GFI++R   +  GK +GE+++YFGCRK+SED++YE EL++  +   + +L  AFSRDQ  K+YVQHL+  E++   IW++I    GHFYICGDAK+MA DV N L+ I  T+G M+ + A  Y+K M+ + R+S+DVWS
Sbjct:   44 RSRKKEEEPTRSYSI--QPTTVCTTSASDNSFIKKLKASGRSLVVFYGSQTGTGEEFAGRLAKEGIRYRLKGMVADPEECDMEELLQLKDIDNSLAVFCLATYGEGDPTDNAMEFYEWITSGDVDLSGLNYAVFGLGNKTYEHYNKVAIYVDKRLEELGANRVFELGLGDDDANIEDDFITWKDRFWPAVCDHFGIEGGGEEVLIRQYRLLEQPDVQPDRIYTGEIARLHSIQNQRPPFDAKNPFLAPIKVNRELHKGGGRSCMHIELSIEGSKMRYDAGDHVAMFPVNDKSLVEKLGQLCNADLDTVFSLINTDTDSSKKHPFPCPTTYRTALTHYLEITAIPRTHILKELAEYCTDEKEKELLRSMASISPEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISSSAKLHPTDVHVTAVLVEYKTPTGRINKGVATTYLKNKQPQGSEEVKVPVFIRKSQFRLPTKPETPIIMVGPGTGLAPFRGFIQERQFLRDEGKTVGESILYFGCRKRSEDYIYESELEEWVKKGTL-NLKAAFSRDQGKKVYVQHLL--EQDADLIWNVIGENKGHFYICGDAKNMAVDVRNILVKILSTKGNMSEADAVQYIKKMEAQKRYSADVWS 679          

Query:  243 KSKTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSI--EGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSG-GHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            +S+ +EE  + ++++   P  + T S+    FI+K+   G+++VVFYGSQTGT E+FA RLAKE +RY LKGM ADPEECDMEELL LK I+NSLA+FC+ATYGEGDPTDNA EFY W+ +  V+++GL Y VFGLGNKTYE++N +  Y D+RL ELGA R+ ELG+GDDD+NIED FITWK+  W +VC+HFGI G   ++ +RQYRL    +V  ++IY GE+ RL + + QRPPFDAKNPFLA + V +EL KGG RS MHIEL I  S+++Y++GDHVA+FP ND  LV+KL +  N +LD V S++  D D+SK+HPFPCPTTYRTAL HY++I    +T++L +L+EY TD+ E + L++++SI  EGK KYQ WI D+ RNI+ +LED+ S + P DH+ ELLPRLQ RYYSISSS K++P  +H+TAVL++Y T TGR  KGV T YL  K P  SE   VP+++R+SQFRLP K ++PIIMVGPG+G+APF+GFI++R   +  GK +GE+++YFGCRK+SED++YE EL++  +   + +L  AFSRDQ  K+YVQHL+  E++   IW++I    GHFYICGDAK+MA DV N L+ I  T+G M+ + A  Y+K M+ + R+S+DVWS
Sbjct:   44 RSRKKEEEPTRSYSI--QPTTVCTTSASDNSFIKKLKASGRSLVVFYGSQTGTGEEFAGRLAKEGIRYRLKGMVADPEECDMEELLQLKDIDNSLAVFCLATYGEGDPTDNAMEFYEWITSGDVDLSGLNYAVFGLGNKTYEHYNKVAIYVDKRLEELGANRVFELGLGDDDANIEDDFITWKDRFWPAVCDHFGIEGGGEEVLIRQYRLLEQPDVQPDRIYTGEIARLHSIQNQRPPFDAKNPFLAPIKVNRELHKGGGRSCMHIELSIEGSKMRYDAGDHVAMFPVNDKSLVEKLGQLCNADLDTVFSLINTDTDSSKKHPFPCPTTYRTALTHYLEITAIPRTHILKELAEYCTDEKEKELLRSMASISPEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISSSAKLHPTDVHVTAVLVEYKTPTGRINKGVATTYLKNKQPQGSEEVKVPVFIRKSQFRLPTKPETPIIMVGPGTGLAPFRGFIQERQFLRDEGKTVGESILYFGCRKRSEDYIYESELEEWVKKGTL-NLKAAFSRDQGKKVYVQHLL--EQDADLIWNVIGENKGHFYICGDAKNMAVDVRNILVKILSTKGNMSEADAVQYIKKMEAQKRYSADVWS 679          

Query:  243 KSKTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSI--EGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSG-GHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            +S+ +EE  + ++++   P  + T S+    FI+K+   G+++VVFYGSQTGT E+FA RLAKE +RY LKGM ADPEECDMEELL LK I+NSLA+FC+ATYGEGDPTDNA EFY W+ +  V+++GL Y VFGLGNKTYE++N +  Y D+RL ELGA R+ ELG+GDDD+NIED FITWK+  W +VC+HFGI G   ++ +RQYRL    +V  ++IY GE+ RL + + QRPPFDAKNPFLA + V +EL KGG RS MHIEL I  S+++Y++GDHVA+FP ND  LV+KL +  N +LD V S++  D D+SK+HPFPCPTTYRTAL HY++I    +T++L +L+EY TD+ E + L++++SI  EGK KYQ WI D+ RNI+ +LED+ S + P DH+ ELLPRLQ RYYSISSS K++P  +H+TAVL++Y T TGR  KGV T YL  K P  SE   VP+++R+SQFRLP K ++PIIMVGPG+G+APF+GFI++R   +  GK +GE+++YFGCRK+SED++YE EL++  +   + +L  AFSRDQ  K+YVQHL+  E++   IW++I    GHFYICGDAK+MA DV N L+ I  T+G M+ + A  Y+K M+ + R+S+DVWS
Sbjct:   44 RSRKKEEEPTRSYSI--QPTTVCTTSASDNSFIKKLKASGRSLVVFYGSQTGTGEEFAGRLAKEGIRYRLKGMVADPEECDMEELLQLKDIDNSLAVFCLATYGEGDPTDNAMEFYEWITSGDVDLSGLNYAVFGLGNKTYEHYNKVAIYVDKRLEELGANRVFELGLGDDDANIEDDFITWKDRFWPAVCDHFGIEGGGEEVLIRQYRLLEQPDVQPDRIYTGEIARLHSIQNQRPPFDAKNPFLAPIKVNRELHKGGGRSCMHIELSIEGSKMRYDAGDHVAMFPVNDKSLVEKLGQLCNADLDTVFSLINTDTDSSKKHPFPCPTTYRTALTHYLEITAIPRTHILKELAEYCTDEKEKELLRSMASISPEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISSSAKLHPTDVHVTAVLVEYKTPTGRINKGVATTYLKNKQPQGSEEVKVPVFIRKSQFRLPTKPETPIIMVGPGTGLAPFRGFIQERQFLRDEGKTVGESILYFGCRKRSEDYIYESELEEWVKKGTL-NLKAAFSRDQGKKVYVQHLL--EQDADLIWNVIGENKGHFYICGDAKNMAVDVRNILVKILSTKGNMSEADAVQYIKKMEAQKRYSADVWS 679          

Query:  609 TVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSI--EGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSG-GHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
             V    + + VFGLGNKTYE++N +  Y D+RL ELGA R+ ELG+GDDD+NIED FITWK+  W +VC+HFGI G   ++ +RQYRL    +V  ++IY GE+ RL + + QRPPFDAKNPFLA + V +EL KGG RS MHIEL I  S+++Y++GDHVA+FP ND  LV+KL +  N +LD V S++  D D+SK+HPFPCPTTYRTAL HY++I    +T++L +L+EY TD+ E + L++++SI  EGK KYQ WI D+ RNI+ +LED+ S + P DH+ ELLPRLQ RYYSISSS K++P  +H+TAVL++Y T TGR  KGV T YL  K P  SE   VP+++R+SQFRLP K ++PIIMVGPG+G+APF+GFI++R   +  GK +GE+++YFGCRK+SED++YE EL++  +   + +L  AFSRDQ  K+YVQHL+  E++   IW++I    GHFYICGDAK+MA DV N L+ I  T+G M+ + A  Y+K M+ + R+S+DVWS
Sbjct:   35 AVAKRKIEWKVFGLGNKTYEHYNKVAIYVDKRLEELGANRVFELGLGDDDANIEDDFITWKDRFWPAVCDHFGIEGGGEEVLIRQYRLLEQPDVQPDRIYTGEIARLHSIQNQRPPFDAKNPFLAPIKVNRELHKGGGRSCMHIELSIEGSKMRYDAGDHVAMFPVNDKSLVEKLGQLCNADLDTVFSLINTDTDSSKKHPFPCPTTYRTALTHYLEITAIPRTHILKELAEYCTDEKEKELLRSMASISPEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISSSAKLHPTDVHVTAVLVEYKTPTGRINKGVATTYLKNKQPQGSEEVKVPVFIRKSQFRLPTKPETPIIMVGPGTGLAPFRGFIQERQFLRDEGKTVGESILYFGCRKRSEDYIYESELEEWVKKGTL-NLKAAFSRDQGKKVYVQHLL--EQDADLIWNVIGENKGHFYICGDAKNMAVDVRNILVKILSTKGNMSEADAVQYIKKMEAQKRYSADVWS 550          

Query:  369 VVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATV---NMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHF---ITWKEDMWTSVCNHFGISGDKI----DINVRQYRLELPAN---VPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGD-RSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDK---LAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALL------HYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDL--PSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINS-GGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            ++V YGSQTGTA+D A ++ +E+ + G +G     +E DM +L     IE  L +F +AT G+G   DN +  + +L   ++   ++ G+++   GLG+ +Y  FN   K   +RL  LGA  +  +G+ DD  +   H    ++W +D+WT++    G+   K+       V+    ELP +    P + +   +     +F               K+L  Q        + V  + L      + +E GD + V P N    V     L +  ++N D+      I E +S     P P  Y   L          D++   +   L  L++   D+ E + L   SS EG      ++   RRN+L VLED    +  +    L E++P +Q R +SI+S        + +  V    I +T R   G+C+++L         + VV    +R     P     P+IMVGPG+GIAPF+  I++R  A+S G  +G  V++FGCR ++ DF + ++      D    + + AFSRDQ  K+YVQHL+A  KN   +  +I     + Y+ G++ +M K V    + I   +         DY+++M  + R+  + W+
Sbjct:    3 LLVLYGSQTGTAQDVAEQIWRESHQLGFQGPVLPFDEYDMTKL-----IEERLVVFVVATTGDGVEPDNMKLAWRFLLKRSLPAQSLQGMQFACLGLGDSSYPKFNYAAKKLSKRLQNLGANSVCPVGLCDDQHDY-GHLGVSLSWTKDLWTALKGISGLDESKLSNSHQTTVKWSVKELPKDSQIAPMDNLLWSQKQTAHSF---------------KILDNQRTTAVDHFQDVRFLRLQCQTEDLSWEPGDVLDVQPQNSDEAVQTFFDLIREHSLNFDES----TIVEVSSAHQDMPLPIAYSNPLSLLQAAKFVWDLSAKPRQRFLEVLAQNCCDEMEKEKLLEFSSAEGIDDLVAYVNRPRRNLLEVLEDFRHATSSLTLQQLFEMMPLIQPRSFSIASDVSALSLDLLVAVVEYKTIMHTPR--LGLCSNWLKTLKSGTELSGVV----KRGTMVWPKDLSIPLIMVGPGTGIAPFRSIIQNRLYAQSKGATIGPLVVFFGCRNKAADFHFGNDF-STWTDAKQVEAHTAFSRDQDQKVYVQHLIA--KNGAHLARLIKDLNAYIYVAGNSNNMPKSVKEAFIEILDGDA--------DYVELMIKQRRYQEETWA 582          

Query:  279 FTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSI--EGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPS-ETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINS-GGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            FTL+ +P + T+       FIEKM K  ++VVVFYGSQTGT E+FANRL+K+A RYG+KGMAADPEE DM EL  LK I  S+A+FCMATYGEGDPTDNAQEFY+WLQ    ++ G+ + VFGLGNKTYE++NAMGKY D+RL+ELG  R+ +LG+GDDDSN+E+ FI+WKE  W +VC +FG+     D ++RQ+ L +  ++  N++Y GE+ RL +F+ Q+PPFDAKNPFLA V V ++L KGG+R +MHIELDIT S+I+Y+SGDHVAV+PTND  +V+++ +RL ++LD VIS+  +DE+++K+HPFPCPTTYRTAL HY+DINN  +TNVL +L++YA+D  E + ++ ++S   EGK  YQ W+LDS RNILA+LEDLPSL  P DHL ELLPRLQ RYYSI+SS K++P+ IHI AV+++Y T TGR  KGV T++L  K+ + +   P VP+YVRRSQFRLP+K  +P+IM+GPG+GIAPF GFI++R+  K  GK +GET++YFGCR  +EDFLY+ EL++  +  V++ L +AFSRDQ  K+YVQHL+  +KN++Q+W +I++   H Y+CGDA++MA+DV+     I + EG +T++QA DY K +  KGR+S DVWS
Sbjct:   54 FTLVTAPIRETS-------FIEKMKKTNRSVVVFYGSQTGTGEEFANRLSKDAHRYGMKGMAADPEEYDMSELSRLKEIPKSMAVFCMATYGEGDPTDNAQEFYDWLQGTDDDLEGVNFAVFGLGNKTYEHYNAMGKYTDKRLAELGGKRVFDLGLGDDDSNLEEDFISWKEQFWPAVCEYFGVEATGEDSSIRQFELVVHNDINMNQVYTGEMGRLKSFQTQKPPFDAKNPFLASVAVNRKLNKGGNRHLMHIELDITESKIRYDSGDHVAVYPTNDSAMVNRIGERLGVDLDAVISLKNLDEESNKKHPFPCPTTYRTALTHYLDINNMPRTNVLYELAQYASDPQEQENMRKMASASPEGKALYQSWVLDSERNILAILEDLPSLNPPIDHLCELLPRLQARYYSIASSSKVHPHCIHICAVVIEYNTKTGRVFKGVATNWLKGKHVTDNGHKPTVPMYVRRSQFRLPFKPSNPVIMIGPGTGIAPFMGFIQERAWQKEQGKDVGETILYFGCRHSNEDFLYQQELEEFERAGVLTQLNVAFSRDQEQKVYVQHLL--KKNKQQLWKLIHTDNAHIYVCGDARNMARDVHAAFSEIAEQEGRLTHTQALDYFKKLMTKGRYSQDVWS 674          

Query:  279 FTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPS-ETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINS-GGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            F  L++ A  T  +S    FI+KM K GKN+VVFYGSQTGTAE+F+NRLAK+A RYG+KGMAADPEE D+ EL  +  I+NSLAIFC+ATYGEGDPTDNAQ+FY+WLQ A  + +GL+YTVF LGNKTYE++NAMGKY D+RL ELGA RI +LG+GDDD N+E+ F++W+E  W +VC HFG+     + ++RQY L++  ++  NK+Y GE+ RL +FE Q+PPFD+KNPFLA V V ++L KGG+R +MH+ELDIT S+I+YESGDHVAV+P ND  +V+K+ + L ++LD VIS+  +DE+++K+HPFPCPTTYRTAL HY+DI N  +TNVL +L++YA+D  + + ++ +  SS EGK +YQ W+LDS RNI+A+LEDLPSL+ P DHL ELLPRLQ RYYSISSS K++PN+IHI AV+++Y T TGR  KGV T++L  K P+ +     VP+Y+R+SQFRLP+KS +PIIM+GPG+GIAPF GFI++R   K  GK +GETV+YFGCR ++EDFLY++EL +  +  V++ L +AFSRDQ++K+YVQH +  + N++ +W ++++   H YICGDA++MA+DV      I +  GGM+  QA DY+K +  KGR+S DVWS
Sbjct:   48 FKKLETAAPTTRDTS----FIDKMKKTGKNIVVFYGSQTGTAEEFSNRLAKDAHRYGMKGMAADPEEYDLSELSRMGEIDNSLAIFCLATYGEGDPTDNAQDFYDWLQEADADFSGLKYTVFALGNKTYEHYNAMGKYVDKRLEELGAQRIFDLGMGDDDGNLEEDFVSWREQFWPAVCEHFGVEATGEESSIRQYELKVHTDLNMNKVYTGELGRLKSFENQKPPFDSKNPFLAPVTVNRKLNKGGERHLMHLELDITGSKIRYESGDHVAVYPINDTAMVNKIGELLAVDLDTVISLNNLDEESNKKHPFPCPTTYRTALTHYLDITNSPRTNVLYELAQYASDPKDQENMRKMASSSAEGKAQYQSWVLDSCRNIVAILEDLPSLRPPIDHLCELLPRLQARYYSISSSSKVHPNSIHICAVVVEYQTKTGRVNKGVATNWLKNKMPTDNGHKATVPMYIRKSQFRLPFKSTNPIIMIGPGTGIAPFIGFIQERGWLKEQGKEVGETVLYFGCRHKNEDFLYQEELAQFEKTGVLTTLNVAFSRDQAEKVYVQHHL--KNNKEAVWKLVHTDNAHIYICGDARNMARDVQTAFYEIAEELGGMSRPQAVDYIKKLMTKGRYSQDVWS 671          

Query:  360 GKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATV---NMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNI-EDHFI-TWKEDMWTSVCNHF----GISGDKIDINVR-QYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGD-RSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLP--SLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDII-NSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            G  V+V YGSQTGTA+D A R+ ++A R  L+  A   E  D   + NL  I  SL +F  AT G+GDP DN ++F+ +L   ++   +++ L   V GLG+ +Y  FN + K   +RL +LGA  +  +G+ DD  ++  D  I  W    W    + +    G++  + +  +  +Y     + VP NK        L   + +  P   + PF A ++  Q +      + V HIE DIT S I++ +GD V + P N    V++L + L ++ +   ++   D         P P + R  L H++DI+   + +    L+ +ATD+ E + L   SS  G+     +    RR  + VL D P  + ++    LL+L P +Q R +SI+SS   +PN I I   ++ Y T   +  KG+C+ +L   +PS  +   VP++V++   + P   +SP+IMVGPG+G+APF+  I++R VA+  GK     V++FGCR +S+DF    E ++  Q   +  L  AFSRDQ DK+YVQH + KE+  K +WD+I      FYI G+AK M   V + L  +FQ EGGM+ +QAQ+ L  M+  GR  S+ WS
Sbjct:    3 GHTVLVLYGSQTGTAQDTAERIGRQAQRRRLRVKA---EALDTYNVANL--ISESLVVFVCATTGQGDPPDNMKKFWRFLFRKSLPADSLSRLDCAVLGLGDSSYPKFNFVAKKLHKRLLQLGANMLLPVGLADDQHDLGPDGVIDPWLLSFWQKTLSLYPPPAGLAPLREEDKLPPRYIFHFLSEVP-NK----PTEHLQTVDNKSSPTSLR-PFPAPLVFNQRVTHTAHFQDVRHIEFDITGSNIEFSAGDIVMMRPCNTAEDVEQLCQLLKLDPESYFTLTPTDSSTEVPARLPQPCSVRFLLEHFLDISAVPRRSFFELLATFATDELEQEKLLEFSSAAGQDALHSYCNRPRRTAIEVLTDFPHTTAELSIGCLLDLFPEIQPRSFSIASSLLEHPNRIQILLAVVKYKTMLVKPRKGLCSSWLASLDPSKGDV-YVPLWVKKGSLKFPQDPESPVIMVGPGTGVAPFRSAIQER-VAQ--GK--MANVLFFGCRSESKDFYCGSEWQEKVQAGQMI-LVTAFSRDQEDKVYVQHRV-KEQG-KLLWDLIAKKNAFFYIAGNAKQMPTSVCDALKAVFQKEGGMSENQAQEMLDGMEKNGRFQSETWS 595          

Query:  360 GKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATV---NMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNI-EDHFI-TWKEDMWTSVCNHF----GISGDKIDINVR-QYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGD-RSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLP--SLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDII-NSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            G  V+V YGSQTGTA+D A R+ ++A R  L+  A   E  D   + NL  I  SL +F  AT G+GDP DN ++F+ +L   ++   +++ L   V GLG+ +Y  FN + K   +RL +LGA  +  +G+ DD  ++  D  I  W    W    + +    G++  + +  +  +Y     + VP NK        L   + +  P   + PF A ++  Q +      + V HIE DIT S I++ +GD V + P N    V++L + L ++ +   ++   D         P P + R  L H++DI+   + +    L+ +ATD+ E + L   SS  G+     +    RR  + VL D P  + ++    LL+L P +Q R +SI+SS   +PN I I   ++ Y T   +  KG+C+ +L   +PS  +   VP++V++   + P   +SP+IMVGPG+G+APF+  I++R VA+  GK     V++FGCR +S+DF    E ++  Q   +  L  AFSRDQ DK+YVQH + KE+  K +WD+I      FYI G+AK M   V + L  +FQ EGGM+ +QAQ+ L  M+  GR  S+ WS
Sbjct:    3 GHTVLVLYGSQTGTAQDTAERIGRQAQRRRLRVKA---EALDTYNVANL--ISESLVVFVCATTGQGDPPDNMKKFWRFLFRKSLPADSLSRLDCAVLGLGDSSYPKFNFVAKKLHKRLLQLGANMLLPVGLADDQHDLGPDGVIDPWLLSFWQKTLSLYPPPAGLAPLREEDKLPPRYIFHFLSEVP-NK----PTEHLQTVDNKSSPTSLR-PFPAPLVFNQRVTHTAHFQDVRHIEFDITGSNIEFSAGDIVMMRPCNTAEDVEQLCQLLKLDPESYFTLTPTDSSTEVPARLPQPCSVRFLLEHFLDISAVPRRSFFELLATFATDELEQEKLLEFSSAAGQDALHSYCNRPRRTAIEVLTDFPHTTAELSIGCLLDLFPEIQPRSFSIASSLLEHPNRIQILLAVVKYKTMLVKPRKGLCSSWLASLDPSKGDV-YVPLWVKKGSLKFPQDPESPVIMVGPGTGVAPFRSAIQER-VAQ--GK--MANVLFFGCRSESKDFYCGSEWQEKVQAGQMI-LVTAFSRDQEDKVYVQHRV-KEQG-KLLWDLIAKKNAFFYIAGNAKQMPTSVCDALKAVFQKEGGMSENQAQEMLDGMEKNGRFQSETWS 595          

Query:  351 VKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATV---NMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSV-----------------C----NHFGISGDKIDINVRQYRLELP-ANVPENKIYK--------GEVTRLGAFEKQRPPFD-------AKNPFLAKVL------VKQELCKGGD-------------------RSVMHIELDITNSRIK-YESGDHVAVFPTNDPILVDKLAKRLNINLDQVISM-VAIDEDNSKRH---PFPCPT--TYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNM-KGVCTHYL---------------NMKNPSPSETPVVPIYVR-RSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGK--PLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDK-------IYVQH-LMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
             +   + ++ YGSQ G A+  A  + ++A  +G     AD       +  NL S E+   +F ++T G+GDP D A +F   ++N ++   +++ LRY + GLG+  Y NF   GK  D  L +LGA   +  G  DD + +E     W E +W ++                 C    NH   S  K ++ V    L+L   + P+ K           G  + + + ++  PP         A  P   ++L      V++ +    D                   ++ + +ELDI+  + + Y+ GD   +   N    V++L  +L++ + +  ++ V + ++ SK+    P   P   + +  L   ++I +  K   L  L ++  + SE   L  L S +G   Y  ++ DS   +L +L   PS   P   L E LP+LQ R YS +SS   +P  +H+   ++++         KG+CT +L                 + P  S  P V +  R  S F LP     P++MVGPG+G+APF GF++ R   + A +    GE  ++FGCR + +DFL+ +EL+K   +  +S L + FSRD+ D         YVQH L+   KN  +I  ++   G  Y+CGDAK+MAKDVN+TLL I   E  +    A   +  ++   R+  D+WS
Sbjct:    3 CEAAAHFLILYGSQRGQAQSIAEEICQQAAEHGF---TADISCLSKHDKYNLDS-ESRPVVFVVSTTGDGDPPDTALKFVRKIKNKSLPHDHLSHLRYALLGLGDTNYANFCNGGKTIDSYLQKLGAKHFYATGHADDGTGLEVVVDPWIEGLWDALKKAFSTMSTSDQQTLSDCTQDSNHQNASDQKKNLEVDLQLLKLSEVDSPKGKTVTSDSIATEIGSTSSVASLKESVPPLSESVLNVPALPPSYLEILLVGTENVEETVLPDKDGYFEVPISKAVQLTQDDAVKTAILLELDISQQQEQVYQPGDAFDILCPNRDSEVEELLLKLDLQMQKNCTVQVNLLKNTSKKAAKVPLHIPQNGSLQFILTWCLEIRSTPKKAFLRALVDFTQNASEKRRLLELCSKQGSADYNSFVRDSSVCVLDLLRAFPSCCPPLSLLFEHLPKLQPRAYSAASSSLQHPGKVHLVFNVVEFPARPEHPARKGLCTGWLVDHVSSILEPHGTALASERPGTSALPKVHVRARPSSTFHLPSDPCVPVVMVGPGTGVAPFIGFLQQREKEREANQEATFGEMWLFFGCRHKDKDFLFREELEKFVHNGTLSHLIVCFSRDEPDAAETVNRPTYVQHNLILHAKNLAKI--LLEDKGCLYVCGDAKNMAKDVNDTLLEIIGNELQLDKLDAMKIVAGLREDKRYLQDIWS 697          

Query:  303 KLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSI--EGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPS-ETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINS-GGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            K+ + S     FIEKM K GKN+VVFYGSQTGT E+FANRLAK+A RYG++GMAADPEE +M +L  L  IEN+LA+FCMATYGEGDPTDNAQ+FY+WLQ   +++ GL+Y VFGLGNKTYE+FNAMGKY D+RL ELGA RI ELG+GDDD N+E+ FITW+E  W +VC HFG+     D ++RQY L +  +   NK+Y GE+ RL ++E Q+PPFDAKNPFLA   V ++L +GGDR  MH+ELDIT S+I+YESGDHVAV+P ND  LV+KL + L  +L+ VIS+  +DE+++K+HPFPCPTTYRTAL +Y+DI NP +TNVL +L++YATD  E + L+ ++S   +GK  Y  W+++SRRNILA+LED+PSL+ P DHL ELLPRLQ RYYSI+SS K++PN+IH+ AVL++Y T TGR  KGV T++L  K PS +     VP++VR+SQFRLP+K  +P+IM+GPG+GIAPF GFI++R   K  GK +GETV+Y+GCR + EDFLY +ELK+ H++ V++ L +AFSRDQ+ K+YVQHL+  + N++ +W +I+    H Y+CGDA++MA+DV N   +I +  G + ++QA DY+K +  KGR+S DVWS
Sbjct:   41 KIQSSSVRESSFIEKMKKTGKNIVVFYGSQTGTGEEFANRLAKDAHRYGMRGMAADPEEFEMTDLSRLTEIENALAVFCMATYGEGDPTDNAQDFYDWLQETDIDLAGLKYAVFGLGNKTYEHFNAMGKYVDKRLEELGAERIFELGMGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEDSSIRQYELVVHTDENMNKVYTGEMGRLKSYETQKPPFDAKNPFLANATVNRKLNEGGDRHFMHLELDITGSKIRYESGDHVAVYPANDAALVNKLGEILGADLETVISLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYATDSKEQENLRKMASSAQDGKALYLSWVVESRRNILAILEDIPSLRPPLDHLCELLPRLQARYYSIASSSKVHPNSIHVCAVLVEYETKTGRENKGVATNWLKNKQPSDNGHKSSVPMFVRKSQFRLPFKPSTPVIMIGPGTGIAPFMGFIQEREWLKQQGKDVGETVLYYGCRHEHEDFLYINELKRYHKEGVLTQLNVAFSRDQAHKVYVQHLL--KNNKEMVWKLIHEDNAHIYVCGDARNMARDVQNIFYDIVEEYGKLDHAQAVDYIKKLMTKGRYSQDVWS 660          

Query:  249 KTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSI--EGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPS-ETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINS-GGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            K +EE I   FT ++       +SS    FIEKM K GKN+VVFYGSQTGT E+FANRLAK+A RYG++GMAADPEE +M +L  L  IEN+LA+FCMATYGEGDPTDNAQ+FY+WLQ   +++ GL+Y VFGLGNKTYE+FNAMGKY D+RL ELGA RI ELG+GDDD N+E+ FITW+E  W +VC HFG+     D ++RQY L +  +   NK+Y GE+ RL ++E Q+PPFDAKNPFLA   V ++L +GGDR  MH+ELDIT S+I+YESGDHVAV+P ND  LV+KL + L  +L+ VIS+  +DE+++K+HPFPCPTTYRTAL +Y+DI NP +TNVL +L++YATD  E + L+ ++S   +GK  Y  W+++SRRNILA+LED+PSL+ P DHL ELLPRLQ RYYSI+SS K++PN+IH+ AVL++Y T TGR  KGV T++L  K PS +     VP++VR+SQFRLP+K  +P+IM+GPG+GIAPF GFI++R   K  GK +GETV+Y+GCR + EDFLY +ELK+ H++ V++ L +AFSRDQ+ K+YVQHL+  + N++ +W +I+    H Y+CGDA++MA+DV N   +I +  G + ++QA DY+K +  KGR+S DVWS
Sbjct:   40 KKKEETIE--FTKIQPTVSSVRESS----FIEKMKKTGKNIVVFYGSQTGTGEEFANRLAKDAHRYGMRGMAADPEEFEMTDLSRLTEIENALAVFCMATYGEGDPTDNAQDFYDWLQETDIDLAGLKYAVFGLGNKTYEHFNAMGKYVDKRLEELGAERIFELGMGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEDSSIRQYELVVHTDENMNKVYTGEMGRLKSYETQKPPFDAKNPFLANATVNRKLNEGGDRHFMHLELDITGSKIRYESGDHVAVYPANDAALVNKLGEILGADLETVISLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYATDSKEQENLRKMASSAQDGKALYLSWVVESRRNILAILEDIPSLRPPLDHLCELLPRLQARYYSIASSSKVHPNSIHVCAVLVEYETKTGRENKGVATNWLKNKQPSDNGHKSSVPMFVRKSQFRLPFKPSTPVIMIGPGTGIAPFMGFIQEREWLKQQGKDVGETVLYYGCRHEHEDFLYINELKRYHKEGVLTQLNVAFSRDQAHKVYVQHLL--KNNKEMVWKLIHEDNAHIYVCGDARNMARDVQNIFYDIVEEYGKLDHAQAVDYIKKLMTKGRYSQDVWS 671          

Query:  249 KTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSI--EGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPS-ETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINS-GGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            K +EE I   FT ++       +SS    FIEKM K GKN+VVFYGSQTGT E+FANRLAK+A RYG++GMAADPEE +M +L  L  IEN+LA+FCMATYGEGDPTDNAQ+FY+WLQ   +++ GL+Y VFGLGNKTYE+FNAMGKY D+RL ELGA RI ELG+GDDD N+E+ FITW+E  W +VC HFG+     D ++RQY L +  +   NK+Y GE+ RL ++E Q+PPFDAKNPFLA   V ++L +GGDR  MH+ELDIT S+I+YESGDHVAV+P ND  LV+KL + L  +L+ VIS+  +DE+++K+HPFPCPTTYRTAL +Y+DI NP +TNVL +L++YATD  E + L+ ++S   +GK  Y  W+++SRRNILA+LED+PSL+ P DHL ELLPRLQ RYYSI+SS K++PN+IH+ AVL++Y T TGR  KGV T++L  K PS +     VP++VR+SQFRLP+K  +P+IM+GPG+GIAPF GFI++R   K  GK +GETV+Y+GCR + EDFLY +ELK+ H++ V++ L +AFSRDQ+ K+YVQHL+  + N++ +W +I+    H Y+CGDA++MA+DV N   +I +  G + ++QA DY+K +  KGR+S DVWS
Sbjct:   72 KKKEETIE--FTKIQPTVSSVRESS----FIEKMKKTGKNIVVFYGSQTGTGEEFANRLAKDAHRYGMRGMAADPEEFEMTDLSRLTEIENALAVFCMATYGEGDPTDNAQDFYDWLQETDIDLAGLKYAVFGLGNKTYEHFNAMGKYVDKRLEELGAERIFELGMGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEDSSIRQYELVVHTDENMNKVYTGEMGRLKSYETQKPPFDAKNPFLANATVNRKLNEGGDRHFMHLELDITGSKIRYESGDHVAVYPANDAALVNKLGEILGADLETVISLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYATDSKEQENLRKMASSAQDGKALYLSWVVESRRNILAILEDIPSLRPPLDHLCELLPRLQARYYSIASSSKVHPNSIHVCAVLVEYETKTGRENKGVATNWLKNKQPSDNGHKSSVPMFVRKSQFRLPFKPSTPVIMIGPGTGIAPFMGFIQEREWLKQQGKDVGETVLYYGCRHEHEDFLYINELKRYHKEGVLTQLNVAFSRDQAHKVYVQHLL--KNNKEMVWKLIHEDNAHIYVCGDARNMARDVQNIFYDIVEEYGKLDHAQAVDYIKKLMTKGRYSQDVWS 703          

Query:  249 KTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSI--EGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPS-ETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINS-GGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            K +EE I   FT ++     + + S    FIEKM K GKN+VVFYGSQTGT E+FANRLAK+A RYG++GMAADPEE +M +L  L  IEN+LA+FCMATYGEGDPTDNAQ+FY+WLQ   +++ GL+Y VFGLGNKTYE+FNAMGKY D+RL ELGA RI ELG+GDDD N+E+ FITW+E  W +VC HFG+     D ++RQY L +  +   NK+Y GE+ RL ++E Q+PPFDAKNPFLA   V ++L +GGDR  MH+ELDIT S+I+YESGDHVAV+P ND  LV+KL + L  +L+ VIS+  +DE+++K+HPFPCPTTYRTAL +Y+DI NP +TNVL +L++YATD  E + L+ ++S   +GK  Y  W+++SRRNILA+LED+PSL+ P DHL ELLPRLQ RYYSI+SS K++PN+IH+ AVL++Y T TGR  KGV T++L  K PS +     VP++VR+SQFRLP+K  +P+IM+GPG+GIAPF GFI++R   K  GK +GETV+Y+GCR + EDFLY +ELK+ H++ V++ L +AFSRDQ+ K+YVQHL+  + N++ +W +I+    H Y+CGDA++MA+DV N   +I +  G + ++QA DY+K +  KGR+S DVWS
Sbjct:   48 KKKEETIE--FTKIQPTVSSSVRES---SFIEKMKKTGKNIVVFYGSQTGTGEEFANRLAKDAHRYGMRGMAADPEEFEMTDLSRLTEIENALAVFCMATYGEGDPTDNAQDFYDWLQETDIDLAGLKYAVFGLGNKTYEHFNAMGKYVDKRLEELGAERIFELGMGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEDSSIRQYELVVHTDENMNKVYTGEMGRLKSYETQKPPFDAKNPFLANATVNRKLNEGGDRHFMHLELDITGSKIRYESGDHVAVYPANDAALVNKLGEILGADLETVISLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYATDSKEQENLRKMASSAQDGKALYLSWVVESRRNILAILEDIPSLRPPLDHLCELLPRLQARYYSIASSSKVHPNSIHVCAVLVEYETKTGRENKGVATNWLKNKQPSDNGHKSSVPMFVRKSQFRLPFKPSTPVIMIGPGTGIAPFMGFIQEREWLKQQGKDVGETVLYYGCRHEHEDFLYINELKRYHKEGVLTQLNVAFSRDQAHKVYVQHLL--KNNKEMVWKLIHEDNAHIYVCGDARNMARDVQNIFYDIVEEYGKLDHAQAVDYIKKLMTKGRYSQDVWS 680          

Query:  249 KTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSI--EGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPS-ETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINS-GGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            K +EE I   FT ++     + + S    FIEKM K GKN+VVFYGSQTGT E+FANRLAK+A RYG++GMAADPEE +M +L  L  IEN+LA+FCMATYGEGDPTDNAQ+FY+WLQ   +++ GL+Y VFGLGNKTYE+FNAMGKY D+RL ELGA RI ELG+GDDD N+E+ FITW+E  W +VC HFG+     D ++RQY L +  +   NK+Y GE+ RL ++E Q+PPFDAKNPFLA   V ++L +GGDR  MH+ELDIT S+I+YESGDHVAV+P ND  LV+KL + L  +L+ VIS+  +DE+++K+HPFPCPTTYRTAL +Y+DI NP +TNVL +L++YATD  E + L+ ++S   +GK  Y  W+++SRRNILA+LED+PSL+ P DHL ELLPRLQ RYYSI+SS K++PN+IH+ AVL++Y T TGR  KGV T++L  K PS +     VP++VR+SQFRLP+K  +P+IM+GPG+GIAPF GFI++R   K  GK +GETV+Y+GCR + EDFLY +ELK+ H++ V++ L +AFSRDQ+ K+YVQHL+  + N++ +W +I+    H Y+CGDA++MA+DV N   +I +  G + ++QA DY+K +  KGR+S DVWS
Sbjct:   42 KKKEETIE--FTKIQPTVSSSVRES---SFIEKMKKTGKNIVVFYGSQTGTGEEFANRLAKDAHRYGMRGMAADPEEFEMTDLSRLTEIENALAVFCMATYGEGDPTDNAQDFYDWLQETDIDLAGLKYAVFGLGNKTYEHFNAMGKYVDKRLEELGAERIFELGMGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEDSSIRQYELVVHTDENMNKVYTGEMGRLKSYETQKPPFDAKNPFLANATVNRKLNEGGDRHFMHLELDITGSKIRYESGDHVAVYPANDAALVNKLGEILGADLETVISLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYATDSKEQENLRKMASSAQDGKALYLSWVVESRRNILAILEDIPSLRPPLDHLCELLPRLQARYYSIASSSKVHPNSIHVCAVLVEYETKTGRENKGVATNWLKNKQPSDNGHKSSVPMFVRKSQFRLPFKPSTPVIMIGPGTGIAPFMGFIQEREWLKQQGKDVGETVLYYGCRHEHEDFLYINELKRYHKEGVLTQLNVAFSRDQAHKVYVQHLL--KNNKEMVWKLIHEDNAHIYVCGDARNMARDVQNIFYDIVEEYGKLDHAQAVDYIKKLMTKGRYSQDVWS 674          

Query:  249 KTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSP--SETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGG-HFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            K ++E I E F+ +++ A    +SS    F+EKM K G+N++VFYGSQTGTAE+FANRL+K+A RYG++GM+ADPEE D+ +L +L  I+ SL +FCMATYGEGDPTDNAQ+FY+WLQ   V++ G+++ VFGLGNKTYE+FNAMGKY D+RL +LGA RI ELG+GDDD N+E+ FITW+E  W +VC  FG+     + ++RQY L +  ++   K+Y GE+ RL ++E Q+PPFDAKNPFLA V   ++L +G +R +MH+ELDI++S+I+YESGDHVAV+P ND  LV+++ + L  +LD ++S+  +DE+++K+HPFPCPTTYRTAL +Y+DI NP +TNVL +L++YA++ SE + L  +  SS EGK  Y  W++++RR+ILA+L+D PSL+ P DHL ELLPRLQ RYYSI+SS K++PN++HI AV ++Y   +GR  KGV T +L  K P+       +VP++VR+SQFRLP+K  +P+IMVGPG+G+APF GFI++R+  +  GK +GET++Y+GCR+  ED+LY +EL + H+D  ++ L +AFSR+Q+ K+YVQHL+ ++K  + +W +I+ GG H Y+CGDA++MAKDV NT  +I    G M ++QA DY+K +  KGR+S DVWS
Sbjct:   45 KKKKEEIPE-FSKIQTTAPPVKESS----FVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATGEESSIRQYELVVHEDMDTAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSTLVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRTKEPAGENGRRALVPMFVRKSQFRLPFKPTTPVIMVGPGTGVAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDK--EHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 678          

Query:  249 KTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSP--SETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKI 1928
            K ++E I E F+ +++ A    +SS    F+EKM K G+N++VFYGSQTGTAE+FANRL+K+A RYG++GM+ADPEE D+ +L +L  I+ SL +FCMATYGEGDPTDNAQ+FY+WLQ   V++ G+++ VFGLGNKTYE+FNAMGKY D+RL +LGA RI ELG+GDDD N+E+ FITW+E  W +VC  FG+     + ++RQY L +  ++   K+Y GE+ RL ++E Q+PPFDAKNPFLA V   ++L +G +R +MH+ELDI++S+I+YESGDHVAV+P ND  LV+++ + L  +LD ++S+  +DE+++K+HPFPCPTTYRTAL +Y+DI NP +TNVL +L++YA++ SE + L  +  SS EGK  Y  W++++RR+ILA+L+D PSL+ P DHL ELLPRLQ RYYSI+SS K++PN++HI AV ++Y   +GR  KGV T +L  K P+       +VP++VR+SQFRLP+K  +P+IMVGPG+G+APF GFI++R+  +  GK +GET++Y+GCR+  ED+LY +EL + H+D  ++ L +AFSR+Q+ K+
Sbjct:   45 KKKKEEIPE-FSKIQTTAPPVKESS----FVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATGEESSIRQYELVVHEDMDTAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSTLVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRTKEPAGENGRRALVPMFVRKSQFRLPFKPTTPVIMVGPGTGVAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKV 603          

Query:  249 KTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQR 950
            K ++E I E F+ +++ A    +SS    F+EKM K G+N++VFYGSQTGTAE+FANRL+K+A RYG++GM+ADPEE D+ +L +L  I+ SL +FCMATYGEGDPTDNAQ+FY+WLQ   V++ G+++ VFGLGNKTYE+FNAMGKY D+RL +LGA RI ELG+GDDD N+E+ FITW+E  W +VC  FG+     + ++RQY L +  ++   K+Y GE+ RL ++E Q+
Sbjct:   45 KKKKEEIPE-FSKIQTTAPPVKESS----FVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATGEESSIRQYELVVHEDMDTAKVYTGEMGRLKSYENQK 273          

Query:  366 NVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATV---NMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNI-EDHFI-TWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVP-ENKI---YKGEVTRLGAFE-------KQRPPFDAKNPFLAKVLVKQELCKGGD-RSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINN-PLKT--NVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLK--VPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIIN-SGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
             ++V +GSQTGTA+D A RL +EA R  L       +  D   + NL  I   L IF  AT G+GDP DN + F+ ++   ++   ++  + + V GLG+ +Y  FN + K   RRL +LG + +    +GDD   +  D  I  W  D+W  +   + +    +DI       E+P  VP  +K    +  EV  +GA E        Q PP + + PFLA V+  Q +      + V  IE DIT+S I + +GD V + P+N      +  + L ++ +Q  ++   +         P P T    +  Y+DI + P ++   +L  LS++A ++ +   L  LSS  G+ +  E+    RR IL VL D P     +P D+LL+L+PR++ R +SI+SS   +P  + I   ++ Y T       G+C+ +L   NP  +    VP++VR      P    +PIIMVG G+G+APF+  I++R      G       ++FGCR++ +DF ++ E +K  Q   ++ L  AFSR+Q  K+YVQH +   +    +W++++  G +FY+ G+AK++  DV+  L++IFQ EG ++ + A  YL  +Q   R  ++ W+
Sbjct:    5 QLLVLFGSQTGTAQDEAERLGREARRRRLGCRV---QALDSYSVANL--IREPLVIFVCATTGQGDPPDNMKNFWRFIFRKSLPSSSLCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPPCLGDDQHELGPDAAIDPWVGDLWEKIMVMYPV---PLDIP------EIPHGVPLPSKFIFQFLQEVPSIGAEELNIASSAPQTPPSELQ-PFLAPVITNQRVTGPQHFQDVRLIEFDITDSNISFAAGDVVFILPSNSEAHTQQFCQVLCLDPNQFFTLKPREPGVPDPPGLPQPCTVWNLVSQYLDIASVPRRSFFELLACLSQHALEREK---LLELSSARGQEELWEYCSRPRRTILEVLCDFPHTAGAIPPDYLLDLIPRIRPRAFSIASSLLAHPRRLQILVAVVKYQTRLKEPRHGLCSSWLASLNPGQAGPVRVPLWVRPGSLVFPKTPDTPIIMVGAGTGVAPFRAAIQERVAHGQTGN-----FLFFGCRQRDQDFYWQTEWQKLEQKGWLT-LVTAFSREQEQKVYVQHRL--RELGPLVWELLDGQGAYFYLAGNAKYLPTDVSEALMSIFQEEGRLSTADASAYLARLQQTLRFQTETWA 598          

Query:  249 KTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITW 788
            K ++E I E F+ +++ A    +SS    F+EKM K G+N++VFYGSQTGTAE+FANRL+K+A RYG++GM+ADPEE D+ +L +L  I+ SL +FCMATYGEGDPTDNAQ+FY+WLQ   V++ G+++ VFGLGNKTYE+FNAMGKY D+RL +LGA RI ELG+GDDD N+E+ FITW
Sbjct:   45 KKKKEEIPE-FSKIQTTAPPVKESS----FVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITW 219          

Query:  312 TQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSE--TPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            T S     F+EKM K G+N++VFYGSQTGTAE+FANRL+K+A RYG++GM+ADPEE D+ +L +L  I+N+L +FCMATYGEGDPTDNAQ+FY+WLQ   V+++G+++ VFGLGNKTYE+FNAMGKY D+RL +LGA RI ELG+GDDD N+E+ FITW+E  W +VC HFG+     + ++RQY L +  ++   K+Y GE+ RL ++E Q+PPFDAKNPFLA V   ++L +G +R +MH+ELDI++S+I+YESGDHVAV+P ND  LV++L K L  +LD V+S+  +DE+++K+HPFPCPT+YRTAL +Y+DI NP +TNVL +L++YA++ SE + L+ +  SS EGK  Y  W++++RR+ILA+L+D PSL+ P DHL ELLPRLQ RYYSI+SS K++PN++HI AV+++Y T  GR  KGV T++L  K P+       +VP++VR+SQFRLP+K+ +P+IMVGPG+G+APF GFI++R+  +  GK +GET++Y+GCR+  ED+LY +EL + H+D  ++ L +AFSR+QS K+YVQHL+  +++R+ +W +I  G H Y+CGDA++MA+DV NT  +I    G M ++QA DY+K +  KGR+S DVWS
Sbjct:   61 TSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLL--KQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTKGRYSLDVWS 677          

Query:  249 KTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSE--TPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGG-HFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            + ++E + E FT +++P   T+ S     F+EKM K G+N+VVFYGSQTGTAE+FANRL+K+A RYG++GMAADPEE D+ +L +L  I N+LA+FCMATYGEGDPTDNAQ+FY+WLQ   V+++G++Y VFGLGNKTYE+FNAMGKY D+RL +LGA RI ELG+GDDD+N+E+ FITW+E  W +VC HFG+     + ++RQY L L  ++   K+Y+GE+ RL ++E Q+PPFDAKNPFLA V   ++L +G +R +MH+ELDI++S+I+YESGDHVAV+P ND  LV++L + L  +LD V+S+  +DE+++K+HPFPCPT+YRTAL +Y+DI NP +TNVL +L++YA D +E + L+ +  SS EGK  Y  W++++RR+ILA+L+D PSL+ P DHL ELLPRLQ RYYSI+SS K++PN++HI AV ++Y T  GR  KGV T +L  K P+       +VP++VR+SQFRLP+K+ +P+IMVGPG+G+APF GFI++R+  +  GK +GET++Y+GCR+ +ED+LY +EL    +D  +S L +AFSR+Q+ K+YVQHL+ ++K  + +W +I+ GG H Y+CGDA++MA+DV NT  +I    G M ++QA DY+K +  KGR+S DVWS
Sbjct:   45 RKKKEEVPE-FTKIQAP---TSSSVKESSFVEKMKKTGRNIVVFYGSQTGTAEEFANRLSKDAHRYGMRGMAADPEEYDLADLSSLPEINNALAVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKYAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGMGDDDANLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVLHTDIDVAKVYQGEMGRLKSYENQKPPFDAKNPFLATVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGEILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYAADPAEQEQLRKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYETKAGRLNKGVATSWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRAAEDYLYREELAGFQKDGTLSQLNVAFSREQAQKVYVQHLLRRDK--EHLWRLIHEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYVKKLMTKGRYSLDVWS 679          

Query:  309 TTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSP--SETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINS-GGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            TT S     F+EKM K G+N++VFYGSQTGTAE+FANRL+K+A RYG++GMAADPEE D+ +L +L  I+NSLA+FCMATYGEGDPTDNAQ+FY+WLQ   ++++G++Y VFGLGNKTYE+FN+MGKY D+RL +LGA RI ELG+GDDD N+E+ FITW+E  W +VC  FG+     + ++RQY L L A+    K+Y GE+ RL ++E Q+PPFDAKNPFLA V   ++L +G +R +MH+ELDI++S+I+YESGDHVAV+P ND  LV++L K L  +LD V+S+  +DE+++K+HPFPCPTTYRTAL +Y+DI NP +TNVL +L++YA++ SE + L  +  SS EGK  Y  W++++RR+ILA+L+D PSL+ P DHL ELLPRLQ RYYSI+SS K++PN++HI AV+++Y T +GR  KGV T +L  K+P+       +VP++VR+SQFRLP+KS +P+IMVGPG+G+APF GFI++R+  +  GK +GET++Y+GCR+  ED+LY +EL + H+D  ++ L +AFSR+Q+ K+YVQHL+  +++++ +W +I+  G H Y+CGDA++MA+DV NT  NI    GGM ++QA DY+K +  KGR+S DVWS
Sbjct:   60 TTSSVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMAADPEEYDLADLSSLPEIDNSLAVFCMATYGEGDPTDNAQDFYDWLQETDLDLSGVKYAVFGLGNKTYEHFNSMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATGEESSIRQYELVLHADTDPAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSNLVNQLGKILGADLDVVMSLKNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEQLHKMASSSGEGKELYLTWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKSGRINKGVATSWLQAKDPAGENGRRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGVAPFIGFIQERAWLQQQGKEVGETLLYYGCRRSDEDYLYREELAQFHKDGTLTQLNVAFSREQAQKVYVQHLL--KRDQEHLWKLIHEDGAHIYVCGDARNMARDVQNTFCNIAAELGGMEHTQAVDYVKKLMTKGRYSLDVWS 678          

Query:  243 KSKTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSI--EGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSG-GHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            +S+ +EE  + ++++   P  + T S+    FI+K+   G+++VVFYGSQTGT E+FA RLAKE +RY LKGM ADPEECDMEELL LK I+NSLA+FC+ATYGEGDPTDNA EFY W+ +  V+++GL Y VFGLGNKTYE++N +  Y D+RL ELGA R+ ELG+GDDD+NIED FITWK+  W +VC+HFGI G   ++ +RQYRL    +V  ++IY GE+ RL + + QRPPFDAKNPFLA + V +EL KGG RS MHIEL I  S+++Y++GDHVA+FP ND  LV+KL +  N +LD V S++  D D+SK+HPFPCPTTYRTAL HY++I    +T++L +L+EY TD+ E + L++++SI  EGK KYQ WI D+ RNI+ +LED+ S + P DH+ ELLPRLQ RYYSISSS K++P  +H+TAVL++Y T TGR  KGV T YL  K P  SE   VP+++R+SQFRLP K ++PIIMVGPG+G+APF+GFI++R   +  GK +GE+++YFGCRK+SED++YE EL++  +   + +L  AFSRDQ  K+YVQHL+  E++   IW++I    GHFYICGDAK+MA DV N L+ I  T+G M+ + A  Y+K M+ + R+S+DVWS
Sbjct:   44 RSRKKEEEPTRSYSI--QPTTVCTTSASDNSFIKKLKASGRSLVVFYGSQTGTGEEFAGRLAKEGIRYRLKGMVADPEECDMEELLQLKDIDNSLAVFCLATYGEGDPTDNAMEFYEWITSGDVDLSGLNYAVFGLGNKTYEHYNKVAIYVDKRLEELGANRVFELGLGDDDANIEDDFITWKDRFWPAVCDHFGIEGGGEEVLIRQYRLLEQPDVQPDRIYTGEIARLHSIQNQRPPFDAKNPFLAPIKVNRELHKGGGRSCMHIELSIEGSKMRYDAGDHVAMFPVNDKSLVEKLGQLCNADLDTVFSLINTDTDSSKKHPFPCPTTYRTALTHYLEITAIPRTHILKELAEYCTDEKEKELLRSMASISPEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISSSAKLHPTDVHVTAVLVEYKTPTGRINKGVATTYLKNKQPQGSEEVKVPVFIRKSQFRLPTKPETPIIMVGPGTGLAPFRGFIQERQFLRDEGKTVGESILYFGCRKRSEDYIYESELEEWVKKGTL-NLKAAFSRDQGKKVYVQHLL--EQDADLIWNVIGENKGHFYICGDAKNMAVDVRNILVKILSTKGNMSEADAVQYIKKMEAQKRYSADVWS 679          

Query:  303 KLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSE--TPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGG-HFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            + TT S     F+EKM K G+N++VFYGSQTGTAE+FANRL+K+A RYG++GMAADPEE D+ +L +L  IE +LAIFCMATYGEGDPTDNAQ+FY+WLQ   V+++G++Y VF LGNKTYE+FNAMGKY D+RL +LGA RI +LG+GDDD N+E+ FITW+E  W +VC HFG+     + ++RQY L +  ++   K+Y GE+ RL ++E Q+PPFDAKNPFLA V   ++L +G +R +MH+ELDI++S+I+YESGDHVAV+P ND  LV++L + L  +LD ++S+  +DE+++K+HPFPCPT+YRTAL +Y+DI NP +TNVL +L++YA++ +E + L+ +  SS EGK  Y  W+L++RR+ILA+L+D PSL+ P DHL ELLPRLQ RYYSI+SS K++PN++HI AV ++Y T TGR  KGV T +L  K P+       +VP+YVR+SQFRLP+K+ +P+IMVGPG+G+APF GFI++R+  +  GK +GET++Y+GCR+  ED+LY +EL   H+D  ++ L +AFSR+Q  K+YVQHL+ K+K  + +W +I+ GG H Y+CGDA++MA+DV NT  +I   +G M ++QA DY+K +  KGR+S DVWS
Sbjct:   58 QTTTSSVKDRSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMAADPEEYDLADLSSLPEIEKALAIFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKYAVFALGNKTYEHFNAMGKYVDKRLEQLGAQRIFDLGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELMVHTDMDMAKVYTGEMGRLKSYENQKPPFDAKNPFLAVVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGEILGADLDIIMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPTEHEQLRKMASSSGEGKELYLRWVLEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYETKTGRINKGVATSWLRAKEPAGENGGRALVPMYVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAGFHKDGALTQLNVAFSREQPQKVYVQHLLKKDK--EHLWKLIHEGGAHIYVCGDARNMARDVQNTFYDIVAEQGAMEHAQAVDYVKKLMTKGRYSLDVWS 678          

Query:  243 KSKTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            + K EE    +  T+L S     T  +    F+ KM  GGKNV+VFYGSQTGTAE+FA RL+K+A RYG+KG+ ADPEECDMEEL  L  IENSLAIFCMATYGEGDPTDNAQEFY+WLQN   +++G+RY VF LGNKTYE++NAMGKY D+RL ELGATRI+E+G+GDDD+NIE+ F+TW+E  W +VC HFG+     D+N+RQ+ +E+  + P+ KI+ GE  RLG+F  Q+PP+D+KNPFLA V+V +EL KGGDRS MHIELDIT SRI+YE+GDHVAVFPTNDP LV+ L  RL ++LDQV+S+  +DE+ SK+HPFPCPTTYRTALLHY+DI +P +T++L +LS+YA D  + +FL+ L  +S EGK  Y EW+    R+IL VL DLPSLK P D+L ELLPRLQ RYYSISSSPK+YP++IHITAVL+DY T TGR +KGV T++L +K+P+    P VPI+VR+SQFRLP+K+ +P+IM+GPG+G+APF+GFI++R   K  GK +G TV++FGCRK++ED+LYE+EL+    D  +S L++AFSR+Q  KIYVQHL+ ++K  ++IW+++ +GGH Y+CGDA++MAKDV++ + +I +  G +  SQA+DY+K +  KGR+S+DVWS
Sbjct:   45 RGKKEEPPTIKKLTVLPS-----TVRADDTNFVNKMKHGGKNVIVFYGSQTGTAEEFAGRLSKDASRYGMKGITADPEECDMEELPQLAEIENSLAIFCMATYGEGDPTDNAQEFYDWLQNGDADLSGVRYAVFSLGNKTYEHYNAMGKYVDKRLEELGATRIYEVGLGDDDANIEEDFVTWREKFWPAVCEHFGVEATGEDVNMRQFAVEIHEDTPKEKIFSGEPARLGSFRNQKPPYDSKNPFLAPVIVNRELHKGGDRSCMHIELDITGSRIRYEAGDHVAVFPTNDPQLVEALGTRLGVDLDQVMSLNNVDEEASKKHPFPCPTTYRTALLHYLDIVSPPRTHILKELSDYAEDPKDKEFLQKLACASEEGKNLYIEWVAKDHRDILTVLTDLPSLKPPIDYLCELLPRLQARYYSISSSPKLYPSSIHITAVLVDYQTRTGRPVKGVATNWLALKHPTNGIKPTVPIFVRKSQFRLPFKASTPVIMIGPGTGLAPFRGFIQERHFLKKEGKEIGPTVLFFGCRKKAEDYLYEEELQSYCMDGSLSHLHVAFSREQQHKIYVQHLIKQQK--EEIWELLEAGGHIYVCGDARNMAKDVHSCMTDIVEELGKIPRSQAEDYVKKLHTKGRYSADVWS 677          

Query:  276 NFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLE-LPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSI--EGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPS--------------ETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            NF  L     L    S    FI+KM    +NVVVFYGSQTGTAE+FA RLAK+A RYG+KGM ADPEEC+M++L +LK IENSLAIFCMATYGEGDPTDNAQEF+ +L N   ++NGL++ VFGLGNKTYE++N+MG + D++L ELG  R+ ELG+GDDD+NIE+ F+TW+E  W +VC HFG+     ++N RQY L  +P ++P+ KI+ GEV R+G+F KQ+PP+DAKNP+LA + V +EL KGGDRS MHI+LDI++S+I+YE+GDHVA++P N P +V+K+ +RL I+LD++ S+  +DED SK+HPFPCP +YRTAL HY+DI NPL+T+VLG+LSEY     + +FL+ ++    EGK  YQ+W+  + RNILAVLED+PSLK P DH++ELLPRLQ R+YSISSSPK++P +IH+TAVL+DY T T R M GVCT +L  K P  +                P VPIYVR+SQFRLP+K  +P++M+GPG+GIAPF+GFI++R+  K  G+ +GET++YFGCR +S DF+Y +EL +  +  V++ L+ AFSRDQ+ K+YVQHLM  ++N++QIW+++N  GH YICGDAK+MAK+V+  L+ I  ++G M+ + A+DY+K +Q+KGR+S+DVWS
Sbjct:   46 NFKKLTVAPVLERADSSEQSFIQKMKNTKRNVVVFYGSQTGTAEEFATRLAKDASRYGMKGMVADPEECEMDKLTDLKDIENSLAIFCMATYGEGDPTDNAQEFFEFLTNGEEDLNGLKFAVFGLGNKTYEHYNSMGIFVDKKLEELGGERVFELGLGDDDANIEEDFVTWREKFWPAVCLHFGVEATGENVNTRQYALSPVPEDLPKEKIFTGEVARVGSFNKQKPPYDAKNPYLAPIRVNKELHKGGDRSCMHIKLDISDSKIRYETGDHVAIYPINSPEIVEKIGQRLGIDLDEIFSLTNVDEDASKKHPFPCPCSYRTALTHYVDITNPLRTHVLGELSEYTDKAEDKEFLQKMTHATEEGKKLYQDWVHKAHRNILAVLEDIPSLKPPPDHIVELLPRLQPRFYSISSSPKVHPKSIHVTAVLVDYTTTTNRRMMGVCTSWLAGKKPPMTNGTVEHDGDSNLRDALPRVPIYVRKSQFRLPFKPSTPVVMIGPGTGIAPFRGFIQERAYLKDEGRMVGETILYFGCRNESVDFIYSEELAEYKEKGVLT-LHTAFSRDQAQKVYVQHLM--DQNQEQIWNLLNENGHIYICGDAKNMAKEVHGVLVKILTSKGSMSEADAEDYIKKLQSKGRYSADVWS 686          

Query:  243 KSKTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSI--EGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            + K EEE  S  F  LK    +    S    FI KM K G+NVVVFYGSQTGTAE+FA RLAK+A RYG+KGM ADPEE  ME+L  L  IEN+LAIFCMATYGEGDPTDN+QEFY+WLQ  + ++ GL++ VFGLGNKTYE++NAMGKY D+RL ELGA RI+E G+GDDD+NIE+ FITWK+  W +VC +FGI+    DI++RQY L+   ++P  K++ GE  RLG+   Q+PPF+AKNPFLA + V +EL K GDRS MHIE DIT SRI+Y++GDH+AV+PTN+  LVD+  +RLN +L QV S+  +DED SKRHPFPCPTTYRTALLHY+DI +  +TNVL +LS+Y  D  +  FL +++    EGK  Y +WI++  R +L VLEDLPS+  P DH+ ELLPRLQ RYYSISSSPKI   T+ ITAVL++Y T TGR+ +GV T +L +K P+    P VP++VR+SQFRLP+K   P+IM+GPG+G+APF+GFI+DR   +  GKP+GETV++FGCR + EDF+YEDELK   +D  ++ L+ AFSRDQ +KIYVQHL+ ++K+  ++W ++  GGH Y+CGDA+HMA DV+  L +I    G MT  +A DYLK M+++GR+S DVWS
Sbjct:   31 RKKKEEEVAS--FKPLKVAPAMDRSESFDPSFISKMKKMGRNVVVFYGSQTGTAEEFAGRLAKDASRYGMKGMVADPEEYSMEDLTKLPDIENALAIFCMATYGEGDPTDNSQEFYDWLQEGSEDLTGLKFAVFGLGNKTYEHYNAMGKYVDKRLEELGAERIYEQGLGDDDANIEEDFITWKDKFWPAVCENFGITSIGEDISMRQYSLQTHDDIPSEKLFTGEPARLGSTRTQKPPFEAKNPFLASITVNRELHKKGDRSCMHIEFDITGSRIRYDAGDHIAVYPTNNSELVDRFGQRLNADLGQVFSLNNVDEDASKRHPFPCPTTYRTALLHYLDITSCPRTNVLKELSDYTEDAKDKAFLASMAQATPEGKELYTDWIINHHRTLLHVLEDLPSVNPPIDHVCELLPRLQARYYSISSSPKINATTVAITAVLIEYTTKTGRHQQGVATSWLKLKRPTDDLQPKVPVFVRKSQFRLPFKPSIPVIMIGPGTGLAPFRGFIQDRQCQRKDGKPVGETVLFFGCRHEDEDFIYEDELKAFLEDGTLTQLHTAFSRDQPEKIYVQHLLRQQKD--EVWRLLELGGHIYVCGDARHMAHDVDEVLHDIVIEHGNMTREKASDYLKKMRSRGRYSCDVWS 666          

Query:  246 SKTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPS-ETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDII-NSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            S+ + E I E F  + +PA    ++S    FIEKM K GKN++VFYGSQTGTAE+FANRL+K+A RYG+KGMAADPEE DM EL  L  I+NSLAIFCMATYGEGDPTDNAQ+FY+WLQ    +M+GL YTVF LGNKTYE++NAMGKY D+RL +LGA RI +LG+GDDD N+E+ F++W+E  W +VC HFG+     ++++RQY L+   ++  NK+Y GE+ RL +FE Q+PPFD+KNPFLA V V ++L K GDR +MH+ELDIT S+I+YESGDHVAVFPTND +LV+KL + L ++LD+VIS+  +DE+++K+HPFPCPTTYRTAL HY+DI +P +TNVL +L++YA+D  + + ++ +  SS EGK  YQ W+LD+ RNILA+LED+PSL+ P DHL ELLPRLQ RYYSI+SS K++PN+IHI AV+++Y T TGR  KGV T++L  K  + +     VP+Y+R+SQFRLP+K+ +P+IM+GPG+GIAPF GFI++R   K  GK +GETVMYFGCR ++ED++Y++EL++A ++ V+  L++AFSRDQ  K+YVQHL+  +KN++ IW +I N   H Y+CGDA++MAKDV +   +I +  GGMT +QA DY+K +  KGR+S DVWS
Sbjct:   42 SRKKPEPIPE-FKKIDTPAPAARETS----FIEKMKKTGKNIIVFYGSQTGTAEEFANRLSKDAQRYGMKGMAADPEEYDMGELSRLSEIKNSLAIFCMATYGEGDPTDNAQDFYDWLQENDDDMSGLNYTVFALGNKTYEHYNAMGKYVDKRLEDLGAKRIFDLGLGDDDGNLEEDFVSWREQFWPAVCEHFGVEASGDELSIRQYELKEHTDINMNKVYTGEIGRLKSFEVQKPPFDSKNPFLAPVTVNRKLNKAGDRHLMHLELDITGSKIRYESGDHVAVFPTNDSVLVNKLGQILGVDLDKVISLNNLDEESNKKHPFPCPTTYRTALTHYLDITHPPRTNVLYELAQYASDPKDQENMRKMASSSPEGKALYQSWVLDASRNILAILEDMPSLRPPVDHLCELLPRLQARYYSIASSSKVHPNSIHICAVVVEYKTKTGRTNKGVATNWLKNKLVTDNGHKSTVPMYIRKSQFRLPFKATNPVIMIGPGTGIAPFVGFIQERGWLKQQGKEVGETVMYFGCRHKNEDYIYQEELEEAEKNAVLPQLHVAFSRDQDQKVYVQHLL--KKNKENIWKLIHNDNAHIYVCGDARNMAKDVQSAFHDIAEELGGMTRTQATDYVKKLMTKGRYSQDVWS 675          

Query:  297 PAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRL-ELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSI--EGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSP-SETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDII-NSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            P  +T Q+S    FI+K+   G+++VVFYGSQTGT E+FA RLAKE VRY LKGM ADPEECDMEEL+NLKSI NSLA+FC+ATYGEGDPTDNA EFY WLQN   +++GL Y VFGLGNKTYE++N +  Y D+RL ELGATR+ +LG+GDDD+NIED FITWK+  W +VC HFGI     D+++RQYRL E    VPE K+Y GE+ RL + + QRPPFDAKNPFLAK+LV +EL KG DRS MHIE DI  S+++Y++GDHVAV+P ND  LV+K+ K  N +LD + +++  DE++SK+HPFPCPTTYRTAL HY+DI    +T+VL +LSEY TD +E + LK ++S   EGK  YQ+W+ +  RNI+ +LED+PS K   DHL ELLPRLQ RYYSISSSPK+YPNT+HITAV+++Y T TGR+ KGVCT +L +K P+P  E P  PI++R+SQFRLP K+++PIIM+GPG+G+APF+GFI++R  AK   K +GETV+YFGCRK++EDF+YE+EL    +  +++ L+LAFSRDQ+ K+YV HL+  EKNR+++W II  + GH YICGDAK MA +V N ++ I Q +G MT  QA  YLK M+ + R+S+DVWS
Sbjct:   60 PTSMTLQTSSDNSFIKKLKSSGRSLVVFYGSQTGTGEEFAGRLAKEGVRYRLKGMVADPEECDMEELVNLKSIPNSLAVFCLATYGEGDPTDNAMEFYEWLQNGDADLSGLNYAVFGLGNKTYEHYNQVAIYVDKRLEELGATRVFDLGLGDDDANIEDDFITWKDKFWPAVCEHFGIESTGEDVSMRQYRLQEFKDEVPE-KLYTGEMARLHSLKNQRPPFDAKNPFLAKILVNRELHKGNDRSCMHIEFDIEGSKMRYDAGDHVAVYPINDSDLVEKIGKLTNTDLDTIFTLINTDEESSKKHPFPCPTTYRTALTHYLDITMNPRTHVLKELSEYCTDPAEKEKLKTMASTSPEGKALYQQWVNEDNRNIVHILEDMPSCKPKLDHLCELLPRLQPRYYSISSSPKLYPNTVHITAVVVEYKTPTGRHNKGVCTTWLALKKPAPGQEPPTAPIFIRKSQFRLPTKTQTPIIMIGPGTGLAPFRGFIQERHQAKEEDKAVGETVLYFGCRKKAEDFIYEEELLNYEKSGLLT-LHLAFSRDQAHKVYVSHLL--EKNREEVWRIIGENNGHLYICGDAKSMAPEVRNIVMKIIQDKGQMTEQQASAYLKKMETQKRYSADVWS 680          

Query:  249 KTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPS-ETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINS-GGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            + + E I E F  L++PA    ++S    FIEKM K GKN+VVFYGSQTGT E+FANRL+K+A RYG+KGMAADPEE DM EL  LK I+NSLAIFCMATYGEGDPTDNAQ+FY+WLQ +  +++G+ +TVF LGNKTYE++NAMGKY D+RLSELGA RI +LG+GDDD N+E+ F++W+E  W +VC HFG+     + ++RQY L++  ++  NKIY GE+ RL +FE Q+PPFD+KNPFL+ V V ++L KGGDR +MH+ELDIT S+I+YESGDHVAV+PTND  +V+KL + L ++LD VIS+  +DE+++K+HPFPCPTTYRTAL HY+D+ +  +TNVL +L++YA+D  + + ++ +  SS EGK  YQ W+LDS RNILA+LEDLPSL+ P DHL ELLPRLQ RYYSI+SS K++PN+IHI AV+++Y T TGR  KGV T++L  K P+ +     VP+Y+R+SQFRLP+KS +P+IM+GPG+GIAPF GFI++R+  K  GK +GETVMYFGCR ++EDFLY++EL+   ++ V++ L +AFSRDQ  K+YVQHL+  + N++++W  I+    H YICGDA++MA+DV +    I +  GGMT++QA DY+K +  KGR+S DVWS
Sbjct:   44 RKKAEAIPE-FKKLETPAPAARETS----FIEKMKKTGKNIVVFYGSQTGTGEEFANRLSKDAQRYGMKGMAADPEEYDMSELSRLKEIDNSLAIFCMATYGEGDPTDNAQDFYDWLQESDADLDGVNFTVFALGNKTYEHYNAMGKYVDKRLSELGAKRIFDLGMGDDDGNLEEDFVSWREQFWPAVCEHFGVEATGEESSIRQYELKVHEDLNMNKIYTGELGRLKSFENQKPPFDSKNPFLSPVTVNRKLNKGGDRHLMHLELDITGSKIRYESGDHVAVYPTNDSNIVNKLGEVLGVDLDTVISLNNLDEESNKKHPFPCPTTYRTALTHYLDVTSCPRTNVLYELAQYASDPKDQENMRKMASSSPEGKALYQTWVLDSSRNILAILEDLPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSIHICAVVVEYQTKTGRTNKGVATNWLKNKVPTDNGHKATVPMYIRKSQFRLPFKSSNPVIMIGPGTGIAPFMGFIQERAWLKQQGKEVGETVMYFGCRHKNEDFLYQEELEAFEKEEVLTQLNVAFSRDQEKKVYVQHLL--KNNKEEVWRQIHKDNAHIYICGDARNMARDVQSVFYEIAEELGGMTHTQAVDYIKKLMTKGRYSQDVWS 676          

Query:  336 FIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSET---PVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINS-GGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            FIEKM K  +NV+VFYGSQTGTAE+FA RL K+A RYG+KGM ADPEE DM EL  L  + NSLA+FCMATYGEG+PTDNAQ FY+W+Q   V++ G+ ++VFGLGNKTY+++NAMGKY DRRL+ELGAT+I +LG+GDDD N+E+ FI+WK   W +VC  FG+   + + +VRQ+ L +  ++  N++Y GEV  L +F+ Q+PPFDAKNP+LA+V V ++L +GG R +MH++LDI+ S+I+Y++GDHVAV+P ND  LV++L +RL I+LD VI++  +DE+ SK+HPFPCPTTYRTAL HY+DI NPL TNVL +LS+YA+D  E + +  +  SS EGK  Y  W+++S RNILAVLEDLPSL  P D+L ELLPRLQ RYYSI+SS K++P +IHI AV+LDY T TGR  KGV T++L  KN   +E    P VPIYVR+SQFRLP+K+ +P+IM+GPG+GIAPF GF+++R+  K  G   GETV+YFGCR ++EDF+Y++EL++  +  V++ L++AFSRDQ  K+YVQHL+  ++N++ +W +I+S   H Y+CGDA++MA+DV+     I +  GG+T++QA DY + +  KGR+S DVWS
Sbjct:   26 FIEKMKKTNRNVIVFYGSQTGTAEEFATRLVKDAQRYGIKGMVADPEEYDMSELPRLTEVVNSLAVFCMATYGEGEPTDNAQGFYDWMQVTDVSLEGVHFSVFGLGNKTYDHYNAMGKYTDRRLAELGATQIFDLGLGDDDGNLEEDFISWKAQFWPAVCAFFGVQPTQEECSVRQFELVVHNDIDLNEVYTGEVGCLKSFQVQKPPFDAKNPYLAEVTVNRKLNQGGSRHLMHLQLDISGSKIRYDAGDHVAVYPVNDVSLVNRLGERLGIDLDTVITLKNLDEEASKKHPFPCPTTYRTALTHYLDITNPLHTNVLFELSQYASDSEERERMCRMSSSSSEGKALYHSWVVESERNILAVLEDLPSLNPPVDYLCELLPRLQARYYSIASSAKVHPTSIHICAVVLDYTTKTGRVFKGVATNWL--KNKVKTEGGPWPTVPIYVRKSQFRLPFKASNPVIMIGPGTGIAPFMGFLQERAWQKQQGNETGETVLYFGCRHKNEDFIYQEELEEFKKAGVLTQLHVAFSRDQEHKVYVQHLL--KQNKEHLWKLIHSNNAHIYVCGDARNMARDVHEAFHEIAEEAGGLTHTQAVDYFQRLMTKGRYSQDVWS 634          

Query:  336 FIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATV---NMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFIT--WKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFD-----AKNPFLAKVLVKQELCKGGD-RSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNS---KRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLP--SLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDII-NSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            F ++M      ++V YGSQTGTA+D A R+ ++A R   +      +  D   + NL  I  +L +F  AT G+GDP DN + F+ ++   ++   ++  L Y V GLG+ +Y  FN + K   +RL +LGA  +  +G+ DD  ++    +T  W    W    + + +        +   R E P   P    +  + T     +K  PP D     A  PF A+++  Q +      + V  I+ DIT S I+Y +GD V + P N P  V++  + L ++ D    +   D   +    R P PC   Y      Y+DI    + +    L+  AT++ E + L   S+ +G+     +    RR  L VL D P  + ++  ++LL+L P +Q R +SI+SS   +PN + I   ++ Y T   +  +G+C+ +L   +P+ S+  V  ++V++   + P    +P IMVGPG+G+APF+  I++R    + GK     V++FGCR +++DF  + E ++  Q   ++ L+ AFSRDQ DKIYVQH + ++   K +WD+I N    FYI G++K M   V + L  +FQ EGG+T  QAQ+ L+ M+  G   S+ WS
Sbjct:   19 FCDRM--STHTLLVLYGSQTGTAQDMAERIGRQAQR---RRTEVRVQSLDSYNVANL--ISETLVVFVCATTGQGDPPDNMKNFWRFVFRKSLPTGSLCRLDYAVLGLGDSSYPKFNFVAKKLHKRLMQLGANALLPVGLADDQHDLGPDGVTDPWLISFWQKTVSLYPMPP-----GLSPLREEDPLP-PRYMFHFLDATTDKPVQKSHPPDDQGPPSAARPFPAQMVSNQRVTDLSHFQDVRLIDFDITGSNIQYNAGDVVMMRPCNSPEDVEQFCQLLRLDPDSYFILNPADGGTAVVPARLPQPCSVRYLVE--QYLDIAAVPRRSFFEVLATLATNELEREKLAEFSTAQGQDDLHSYCNRPRRTALEVLADFPHTTAELSVNYLLDLFPEIQPRSFSIASSLLAHPNRLQILVAVVSYKTRLQKPRRGLCSSWLASLDPTQSDVSVS-LWVKKGSLKFPQDLDTPAIMVGPGTGVAPFRAAIQERI---AQGK--RANVLFFGCRSETKDFYCQSEWEEKVQAGHMT-LFTAFSRDQEDKIYVQHRVKEQA--KLLWDLIANKNAVFYIAGNSKQMPTGVCDALKEVFQQEGGVTEIQAQEMLEAMEKAGHFQSETWS 618          

Query:  318 SSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQN------------------------------------------ATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLG---AFEKQRPPFDAKNPFLAKVLVKQEL-CKGGDRSVMHIELDITNSR-IKYESGDHVAVFPTNDPILVDKLAKRLN--INLDQVISMVAIDEDNS-----------KRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRN--MKGVCTHYLNMKNPSPSETPVVPIYVRRS-QFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSV-AKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQS-DKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVW 2153
            + L G  + K VK      + + ++TG ++D+A  L  E  ++         EE D+ +L +      +L +   +T+G GDP +N ++F   L                                            +T  +  +R++VFGLG++ Y +F A     D    ELG  RI  +G GD+    E+ F TW + ++ + C+ F + GD  D+N+ +    L +N    K  K  VT      A  +       K  + AKVL++Q L     +RS ++I+L   N   +KY  GDH+ ++P N   LV  L  +L      +Q++ +  ++E N+            R P   P T   A  +++DI  P    +L   +  AT++ +   L+ LS  +G  +Y+EW   +   ++ VLE+ PSL+VP   LL  LP LQ RYYSISSSP ++P  IH+T  ++ Y T  G      GVC+ +LN    S     +VP +VRR+  FR+P  S+ P I+VGPG+GIAPF+ F + R    ++ G      ++ FGCR+   D +Y++E  +A    V  +LY A+SR+    K YVQ ++ ++ +      +   GGH Y+CGD   MA DV  T+  I + +G M+   A  Y+  ++++ R+  D++
Sbjct:  729 AKLMGQAMAKRVKA----TILFATETGKSQDYAKTLC-EIFKHAFDAKVMSMEEYDVVDLEH-----ETLVLAVTSTFGNGDPPENGEKFGAALMEMRHPTTSAEDRKSYKVRFNSVSSYSDTRKSSSDEPESKANFESTGPLANVRFSVFGLGSRAYPHFCAFAHAVDTLFEELGGERILRMGEGDELCGQEESFRTWAKKVFKAACDVFCV-GD--DVNIEKANDSLISNDRSWKKSKFRVTYTAEAPALTQALYNIHKKKVYGAKVLMRQNLQSVKSNRSTIYIQLHANNHESLKYLPGDHLGIYPGNYEDLVTALIDKLEDAPPANQIVRVEFLEERNTALGVISNWTDESRIP---PCTIHQAFKYFLDITTPPSPLLLQQFAPLATNEKQRKRLEVLS--KGLQEYEEWKWYNNPTMVEVLEEFPSLQVPCTLLLTQLPLLQPRYYSISSSPDLHPGEIHLTVAVVSYRTRDGAGPVHHGVCSSWLN----SVEAGDMVPCFVRRAPSFRMPKDSRVPCILVGPGTGIAPFRSFWQQRLYDLENKGIKACPMILVFGCRQSQMDHIYKEETIQAKNKEVFKELYTAYSREPGRPKKYVQDVLREQLSETVYRCLREEGGHIYVCGDVT-MAGDVLKTVQQIVKLQGNMSLEDAGFYISKLRDENRYHEDIF 1382          

Query:  324 LSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENS-LAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGI-----SGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQEL-CKGGDRSVMHIELDITNSR--IKYESGDHVAVFPTNDPILVDKLAKRL-NIN-LDQVISMVAIDEDN--------SKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRN--MKGVCTHYLNMKNPSPSETPVVPIYVRRSQ-FRLPYKSKSPIIMVGPGSGIAPFKGFIEDR-SVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSD-KIYVQHLMAKEKNRKQIWDIIN-SGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVW 2153
             S   + K +K      + Y ++TG ++ FA +L        +   A +P    ME+  N   +E   L I   +T+G G+P  N + F   L +     N +RY VFGLG++ Y  F A     D +L+ELGA  +  +G GD+ +  E+ F  W    + +VC  FGI       +++  N    R  +  +          + R+ A         +K+    K   ++ L      RS + +EL++   +  +KY  GDHV VFP N P LV  + K L NI  ++Q + +  + + +          R P  CP     AL + +DI  P   + L  LS+    + E   L  L+  +    Y EW    R N L +LE+ PSL+V    LL  LP ++ R YS+SSSP ++P+ +H+T  +++Y    G+     GVC+ +LN    +  E  +VP ++  S  F LP   +SP I++G GSGIAPF+ F + R    K  G      ++ FGCR    D LY++E  +   ++ +  +  A+SR     K+YVQ ++ K+ + +++W +++ + GH Y+CG   +MA+DV   +  I  +  GM+ ++A +YL+ ++ + R+  D++
Sbjct:  470 FSQTLMRKALKNRVPCTILYATETGKSQTFAKKLKI------ILSSAFNPRLLCMEDY-NFHELEKERLLIVVTSTFGNGEPPGNGESFKKHLFSIKNLRNKVRYCVFGLGSRMYPQFCAFAHAVDDKLAELGAKCVTPIGEGDELNGQEEAFSAWACTAFKAVCKEFGIESQLSGAERLTDNWEPQRHRVQPD-------SSTLDRISALSA----LHSKSVLSMKFKRRKNLQSPQSKRSTILVELEVHGGKDDLKYAPGDHVGVFPGNSPELVTGILKHLTNIPPINQSLRLEYLPDSSLGGTQWQADPRIP-ACPLA--KALTYLLDITTPPSQSFLRKLSQMTKKEDERQLLMALA--KDFKSYSEWKAFRRPNFLEILEEFPSLEVSAAFLLSQLPLMKPRLYSVSSSPDLHPHELHLTVSVVNYRPQDGKGPLHHGVCSTWLN----TLKEGHLVPCFIHGSSGFHLPPDPRSPTILIGAGSGIAPFRSFWQQRYHDMKKTGLNGSPMMLVFGCRGSDTDHLYKEETYEMRDNSTLKSITPAYSRQPGQPKVYVQDVLKKQLS-EEVWQVLHQNSGHLYVCGGI-NMARDVARAIQEILISRLGMSVTEAGEYLEKLKAEKRYHEDIF 1075          

Query:  303 KLTTQSSLSGGFIEKMVKG---GKNVVVFYGSQTGTAEDFANRL---AKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPS-ETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            ++ T +     FI KMVK     ++ +  +GS  G+   F  R    +   VR GLKG   +  +    EL  L  IENSLA+FCMATYGEGDPTDNAQEFY+ LQ  ++ + G++Y VFGLGNKTYE+FNAMGKY D+RL ELGA RI ELG GDDD+ +E+ FITWKE  W +VC +FG+     D ++RQY L + A+V  NK++ GE++RL ++E Q+PPFDAKNP+L+ V V ++   G DR  MH+ELDI+ S+++YE+GDHVAVFPTND  LV++LA+ L  +LD V S+  +DE+++K+HPFPCPTTYRTALLHY+DI NP +TNVL +L++YA+D  E +FL+ +  S++E K +YQ W+LD RR+ILA+L+DLPS+K P DHL ELLPRLQ RYYSI+SS K++P++IHI AVL++Y T  GR  +GV T +L  + PS +   P VP YVR+SQFRLPYK  SPIIM+GPG+G+APF GFI++R   K  GK +GETV+YFGCR +S DF+YE+EL+   +  V++ L++AFSRDQ +K+YVQHL+   KN++ IW ++ S  H Y+CGDAK+MA+DV   +  +    GG+T  QA D++K +Q KGR+SSDVWS
Sbjct:   60 QIPTTAPRETSFINKMVKTYFVPRSAIFDFGSPHGSRTVFIWRFCVGSGNTVR-GLKG-KKEIGDISGTELPQLTKIENSLAVFCMATYGEGDPTDNAQEFYDLLQEGSLELAGVKYAVFGLGNKTYEHFNAMGKYLDKRLEELGAERIFELGSGDDDATLEEDFITWKERFWPAVCEYFGVEPTGDDASIRQYELVIDADVNRNKVFVGEMSRLKSYETQKPPFDAKNPYLSPVTVNRKTNCGNDRHFMHLELDISGSKMRYEAGDHVAVFPTNDSALVEELARLLGADLDTVFSLNNLDEESNKKHPFPCPTTYRTALLHYLDITNPPRTNVLYELAQYASDPKEQEFLRRMASSAVECKTQYQSWVLDERRHILAILQDLPSVKPPIDHLCELLPRLQARYYSIASSAKVFPDSIHICAVLVEYKTRLGRTNRGVATSWLQGRCPSQNGHKPTVPAYVRKSQFRLPYKPSSPIIMIGPGTGLAPFLGFIQEREWQKQQGKEVGETVLYFGCRNRSTDFIYEEELEAFKERGVLTQLHVAFSRDQEEKVYVQHLIT--KNKENIWQLLQSNAHIYVCGDAKNMARDVQAAISEVVSECGGLTQQQALDFVKKLQTKGRYSSDVWS 682          

Query: 1023 RSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHP------FPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGR--NMKGVCTHYL-----------NMKNPSPSETPVV------PIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAG-KPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQ------------SDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            ++ + ++LD++++      GD + V   N    VD L +RL ++     ++    + N++          P  ++ R+ L H ++I    K  ++  L+E+  D++E   L  LSS +G   Y   + D+   + A+L   PS + P   L+E LPRLQ R YSI+SSP + P   H+   ++++    GR    +GVCT +L           N +  + S  P+       P   + + FRLP  +  PIIM+GPG+G+APF GF++ R      G   LGE+ ++FGCR +  DFLY ++L+       ++ L +AFSRD+            +   YVQH + + +    +  ++  G   Y+CGDAK+MA+DV  TL+++   E G+   +A   +  ++ +GR+  DVW+
Sbjct:  265 KTALELQLDVSDAPFALCPGDALGVLCPNGEAEVDALLRRLGLDGQADCTLELRAKPNARGRASKVPDFIPAGSSLRSILTHGLEIRALPKKAMVRALAEHTEDEAERRRLLELSSRQGSADYTHLLRDASLGLAALLHAFPSCRPPASLLIEHLPRLQPRAYSIASSPLVTPGAAHVVFNVVEFAAGPGRPQAQRGVCTGWLAEVVVGPEAKGNSRPSNLSGAPLADPKLLSPKAAKSTGFRLPEDASVPIIMIGPGTGVAPFVGFLQHREHKAGGGTAALGESWLFFGCRHRDRDFLYREQLEGFVARGTLTHLRVAFSRDEPAGSEVASPGGVAHPRYVQHSLGQHRA-DVMRLLLQEGARLYVCGDAKNMARDVQETLVDMVVEEMGVAKLEAMRVIGGLKEQGRYLQDVWT 679          

Query:  363 KNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVF---GLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCN 818
            +  ++ YG++ GTA+  A  L  +A R+GL        + D+  L        SL             T       + L++  V    L  + F   GLG+  Y NF   G+  DRRL+ELGA R ++ G  DD    E     W E +W ++ +
Sbjct:    2 RRFLLLYGTEIGTAKAIAQDLCAQAERFGL--------DADLHCLSKTHDESGSLTWI-------PSETKEKHRLNSCLKSVIVVYRELTVSCFFSAGLGDTNYTNFCNCGRTMDRRLAELGAQRFYQTGHADDAVGTELVAEPWVEGLWEALVS 141          

Query: 1848 DELKKAHQDNVISDLYLAFSRDQSD-KIYVQHLMAKEKNRKQIWDIINS-GGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            DE++ A    + S+++ A+SR+ S  K+YVQ L+ +E+   Q++  +   GGH Y+CGD   MA DV  T+  +    G ++  +A   +  ++ +GR   D++ 
Sbjct:    2 DEMELARSKGIFSEVHTAYSREPSTPKMYVQDLL-RERLGAQVFSALQERGGHLYVCGDVT-MAGDVLKTVQQVLSRHGDISLEKAGQIVSRLRKEGRLHEDIFG 104          

Query:  627 LRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDIN 854
            L ++VFGLG++ Y +F A G   D  L +LG  RI  +G GD+    E+ F TW   ++ + C+ F + GD ++++
Sbjct:  522 LMFSVFGLGSRAYPHFAAFGHAVDALLGDLGGERILRIGEGDELGGQEEAFRTWARRVFQAACDVFCV-GDDVNMD 596          

Query:  594 WLQNAT-------VNMNGLRYTVFGLGNKTY-ENFNAMGKYFDRRLSELGATRIHELGIGDDDSNI 767
            WL+ A         ++ G+RY VFGLG+  Y E++N +GK  D+ L +LGA R+  L  GD D N+
Sbjct:   62 WLEEAASDFRYGKTHLRGVRYAVFGLGDSVYQEHYNTVGKNMDKWLWQLGARRV--LPRGDGDFNV 125          

Query:  285 LLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAV-RYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVN-MNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDH-FITWKEDMWTSVCNHFGISGDKIDINVR-QYRL------ELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLK----VPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNT---GRNMKGVCTHYL-------NMKNPSPSETPV---------------VPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGK------PLGETVMYFGCRKQSEDFLYEDELKK-AHQDNVISDLYLAFSR-DQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVW 2153
            L+     +T  SS +    + + +  KN +V Y SQTGTAED+A + +KE V ++ L  M AD E  D E L ++  I   ++IF ++TYGEGD  D A  F +++ NA    ++ LRY +FGLGN TYE FN   K  ++ LS  GA R+ +LG  DD +   D  ++ WK+ +   + +   +   +     + QY +       +    P             A   Q  PFD   P++A ++  +EL    DR+ +H E D++ S IKY +GDH+AV+P+N    V++     N++ + +  +  +D   + + PFP PTT   A+ HY++I  P+   +   L ++A +    + L  LS  + K ++   I     NI   L+ L        VP   L+E +P++  RYYSISSS      T+H+T+++ ++          + GV T+ L       N  N + +  PV               +P++VRRS FRLP    +P+IM+GPG+G+APF+GFI +R     + K       LG+ ++++G R  ++DFLY+DE  + A + +   ++ +A SR   + K+YVQ  +   ++  Q++++IN+G   Y+CGDAK MAK V+  L+ I      +T  +A + +KM++  GR+  DVW
Sbjct:   33 LMSDDGDITAVSSGNRDIAQVVTENNKNYLVLYASQTGTAEDYAKKFSKELVAKFNLNVMCADVENYDFESLNDVPVI---VSIF-ISTYGEGDFPDGAVNFEDFICNAEAGALSNLRYNMFGLGNSTYEFFNGAAKKAEKHLSAAGAIRLGKLGEADDGAGTTDEDYMAWKDSILEVLKDELHLDEQEAKFTSQFQYTVLNEITDSMSLGEPSAHYLPSHQLNRNADGIQLGPFDLSQPYIAPIVKSRELFSSNDRNCIHSEFDLSGSNIKYSTGDHLAVWPSNPLEKVEQFLSIFNLDPETIFDLKPLDP--TVKVPFPTPTTIGAAIKHYLEITGPVSRQLFSSLIQFAPNADVKEKLTLLS--KDKDQFAVEITSKYFNIADALKYLSDGAKWDTVPMQFLVESVPQMTPRYYSISSSSLSEKQTVHVTSIVENFPNPELPDAPPVVGVTTNLLRNIQLAQNNVNIAETNLPVHYDLNGPRKLFANYKLPVHVRRSNFRLPSNPSTPVIMIGPGTGVAPFRGFIRERVAFLESQKKGGNNVSLGKHILFYGSR-NTDDFLYQDEWPEYAKKLDGSFEMVVAHSRLPNTKKVYVQDKLKDYED--QVFEMINNGAFIYVCGDAKGMAKGVSTALVGILSRGKSITTDEATELIKMLKTSGRYQEDVW 691          

Query:  942 KQRPPFDAKNPFLAKVLVKQELCKGG-DRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPV---VPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQD-NVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICG 2015
            K RP    KN F+ KV   + +     DR + HIE DI+ + + Y+ G+ + +   N+  LV +      +N   V+ +      N   H      T   A +  +DI           L  YA+++ E   L++L +  G +  + +          + E  PS++   + L+ ++  L+ R YSI+SS K++PN +H+  V++D++ N GR   G  + Y+       S+  V   + + V+ S  +LP   K P+IM G G+G+APFK  +E++   K  G  +GE  +Y G R + E++LY  EL +A++D  +I+ +  AFSRDQ  KIY+Q  + KE   +    +I++ G FY+CG
Sbjct:  641 KLRPDLPVKN-FVVKVKENRRVTPADYDRYIFHIEFDISGTGMTYDIGEALGIHARNNESLVKEFLTFYGLNESDVVLV-----PNKDNHHLLETRTVLQAFVENLDIFGKPPKRFYESLIPYASNEEEKKKLEDLVTPAGAVDLKRFQDVEYYTYADIFELFPSVRPSLEELVTIIEPLKRREYSIASSQKVHPNEVHLLIVVVDWVDNKGRKRYGQASKYI-------SDLAVGSELVVSVKPSVMKLPPSPKQPVIMSGLGTGLAPFKAIVEEKLWQKQQGYEIGEVFLYLGSRHKREEYLY-GELWEAYKDAGIITHIGAAFSRDQPQKIYIQDRI-KENLDELKTAMIDNKGSFYLCG 988          

Query:  351 VKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQE--------FYNWLQNATVN---MNGLRYTVFGLGNKTYENFN-AMGKYFDRRLSELGATRIHELGIGDDDS----------NIEDHFITWKEDMWTSVCNHF---GISGDKIDINVRQYRLELPANV---PENKIYKGEVTRLGAFEKQRPPFDAKNPF-LAKVLVKQELCKGGD-RSVMHIEL-DITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINL---DQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKS-----------EADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYL-NMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWD--------IINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQ-AQDYLKMMQNKGRHSSDVW 2153
            +   K +V+ YGS+TG A DFA  L+    R+          + D +++L  +     L I C +T G+G+   N           F+++L+   +    +N ++  + GLG+ +Y  FN  + K   R +++LGA  + +    DD +           IE  +  +++ + + + + +    ++G  I       R EL   V   P + +   +      F   +  F+      + +V + + +   G  + V   +  ++   +  YE GD V ++P N    V +     +  L   D+ ++  +   ++ K      P T R  L ++ D  +  +T+    +  +ATD +           + + L+  ++ +      ++    RR+IL VLED  S+K+P  ++L+ LP ++ RYYSISS P      I +T  ++ Y T   +  +G+CT+Y+  ++        +   ++ + +F        P+I+VGPG G+AP    ++   ++K       +  + FGCR + +D++Y+D L+   +   I+ L+ +FSRD+ +   V+++      +  +W         ++N    F++CG +  M   V  T + + +  G  ++ + A+ YLK M+   R+  + W
Sbjct:    1 MSSSKKIVILYGSETGNAHDFATILSHRLHRWHFSHTFCSIGDYDPQDILKCRY----LFIIC-STTGQGELPRNVNALKGERPVTFWSFLKRKNLPSNLLNHIQTAMLGLGDSSYPKFNYGIRKLHQRIVTQLGANELFDRLEADDQAMAGSNKGTGLGIESVYFEYEKKVLSFLLSKYPNRKVNGQIIK------REELDPEVYLEPASYLQLSDEHANEKFTSTKVIFEGDESLKVGRVNINKRITSEGHFQDVRQFKFSNVDKIQENYEPGDTVTIYPCNTDEDVSRFLANQSHWLEIADKPLNFTSGVPNDLKDGGLVRPMTLRNLLKYHCDFMSIPRTSFFLKIWTFATDVTKMERGQEQLNDQREKLRQFATDQDMQDLYDYCNRPRRSILEVLEDFISVKLPWKYVLDYLPIIKPRYYSISSGPGDP--NIELTVAIVKYKTILRKIRRGICTNYIARLQEGEQIRYKLQNNHIIKKEFL-----NKPMILVGPGVGLAPLLSVVK-AEISK-------DIKLLFGCRYKDKDYIYKDMLEDWFRKGKIA-LHSSFSRDEENSPGVKYV------QDYLWRLGEEITNLVVNKDAVFFLCGSSGKMPIQVRLTFIEMLKKWGNFSDEETAKKYLKEMEKSDRYIQETW 623          

Query:  255 EEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKG--GKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNAT-VNMNGLRYTVFGLGNKTY-------ENFNAMGKYFDRRLSELGATRIHELGIGDDD--SNIEDHFITWKEDMWTSVCNHFGISGDKID 848
            ++ ++S N       A    Q   S    +++++G  G  + V+Y S  G A + A RLA  A   GLK      ++  +EEL   +++     +F  +T G+G+   + + F+  L+N T +++  L   VFGLG+  Y         FN   +   +RL  L A  +  LG+GDD      +  +  W+  +W ++    G+SG  +D
Sbjct:  642 KDPSLSRNLKQSAGDALTRKQEKRSKAAFDQLLEGLSGPPLHVYYASDGGNAANLAKRLAARASARGLKATVLSMDDIILEELPGEENV-----VFITSTAGQGEFPQDGKSFWEALKNDTDLDLASLNVAVFGLGDSEYWPRKEDKHYFNKPSQDLFKRLELLSAKALIPLGLGDDQDADGFQTAYSEWEPKLWEAL----GVSGAAVD 842          

Query:  285 LLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINV-----RQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            L+ +P+ +  QS+    FI K+ K GK + +FYGSQTGTAE+FA+RLAK+A RYG+K M  DPEE DMEEL  +  I+NS AIF MATYGEGDPTDNAQEFY WLQN   +++ L + VFGLGNKTYE++N+MG+Y D+RL ELG  RI++ G GDDD NIE+ F+ W+E+ W +V  +F I+   I   +     RQ+RL    + P+ K++ GE+ RL A+E+QRPP+DAKNPFLA +++ +EL KGGDRS MHIELDIT S IKY++GDHVAV+PTN+  LV+K ++ LN++LD V S+  +DED SK+HPFPCPTTYRTAL+HY+DI + +KT+VL +L+EYA D  E +FL  +  S+ E K KY EW++   R+I+AVLED+PSLK P DH+LELLPRLQ RYYSISSSPK +P+ IH+TAV++ + T TGR   GV T +L  K P       VPI+VRR+ FRLP+K  +P+IM+GPG+G+APF+GFI+DR+     GK +G+TV++FGCR +++D++YE+EL+    D  IS L++AFSRDQ  K YV HLM   +N  +IW++++ G H Y+CGDA++MA+DV+  +  I + +GGMT+SQA DY+K +  KGR+++DVWS
Sbjct:   45 LMVAPS-IIKQSADDNSFIGKLKKSGKPLAIFYGSQTGTAEEFASRLAKDAQRYGIKAMVFDPEENDMEELTRMGEIDNSFAIFVMATYGEGDPTDNAQEFYEWLQNDRDDLDCLNFAVFGLGNKTYEHYNSMGRYVDKRLEELGGYRIYQRGEGDDDGNIEEDFVRWREEFWPAVLKYFNINVRDIKRRLSSCIERQFRLNEQRDTPQEKVFTGEIARLKAYERQRPPYDAKNPFLAPIVINRELHKGGDRSCMHIELDITGSGIKYDAGDHVAVYPTNNLDLVEKFSQLLNVDLDTVFSLDNVDEDASKKHPFPCPTTYRTALMHYVDITSTVKTHVLRELAEYARDHEEKEFLMAISDSTEEAKKKYNEWVIQPHRHIVAVLEDMPSLKPPLDHILELLPRLQCRYYSISSSPKAHPSHIHVTAVVVKWTTKTGRVQNGVATTWLATKIPKGW----VPIFVRRTTFRLPFKPVTPVIMIGPGTGLAPFRGFIQDRNALVKQGKRVGDTVLFFGCRHKAQDYIYENELEDYAADGTISRLHVAFSRDQDKKRYVTHLM--RENTDEIWNLLDQGAHIYVCGDARNMARDVHTIVTEIAREKGGMTDSQADDYVKKLSAKGRYATDVWS 668          

Query:  360 GKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINV-----RQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAK--RLNINLDQVI-SMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKI-KYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNP 1622
            GK + +FYGSQTGTAE+FA+RLAK+A RYG+K M  DPEE DMEEL  +  I+NS AIF MATYGEGDPTDNAQEFY WLQN   +++ L + VFGLGNKTYE++N+MG+Y D+RL ELG  RI++ G GDDD NIE+ F+ W+E+ W +V  +F I+   I   +     RQ+RL    + P+ K++ GE+ RL A+E+QRPP+DAKNPFLA +++ +EL KGGDRS MHIELDIT S I   SG       T    L+ +L K      +L  VI S     ED SK+HPFPCPTTYRTAL+HY+DI + +KT+VL +L+EYA D  E +FL  +  S+ E K+ KY EW++   R+I+AVLED+PSLK P DH+LELLPRLQ RYYSISSSPK +P+ IH+TAV++ + T TGR   GV T +L  K P
Sbjct:    1 GKPLAIFYGSQTGTAEEFASRLAKDAQRYGIKAMVFDPEENDMEELTRMGEIDNSFAIFVMATYGEGDPTDNAQEFYEWLQNDRDDLDSLNFAVFGLGNKTYEHYNSMGRYVDKRLEELGGNRIYQRGEGDDDGNIEEDFVRWREEFWPAVLKYFNINVRDIKRRLSSCIERQFRLNEQRDTPQEKVFTGEIARLKAYERQRPPYDAKNPFLAPIVINRELHKGGDRSCMHIELDITGSGINARSGFKCR---TKKKQLIQRLRKIPECRKSLSNVIFSTFFFSEDASKKHPFPCPTTYRTALMHYVDITSTVKTHVLRELAEYARDHEEKEFLMAISDSTEEAKVKKYNEWVIQPHRHIVAVLEDMPSLKPPLDHILELLPRLQCRYYSISSSPKAHPSHIHVTAVVVKWTTKTGRVQNGVATTWLATKIP 429          

Query:  357 GGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATV---NMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFIT--WKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGD-RSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLP--SLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHF-YICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            G K + V YGSQTGTA++ A R+ +E  R  +       ++ ++ +L     I+  L +F  AT G+GD  DN ++F+ ++    +   ++  L ++V GLG+ +Y  FN + K  ++RL +LGA+ +  +G+ DD  ++    +   W +++W  V   F +      + +       PA      IY        + E   P    + PF A ++    +      + V  ++LDI+ S I Y  GD V V P+N     ++    L+++ D+  ++   + D       P P + R  + HY+DI    +      LS +   + E + L++ +S EG+     +    +R+ L VL+D P  S  +P ++LL+L+P +Q R +SI+S+ K +P+ I I   ++ Y T   +  +G+C+ +L+   PS S    VP++V+R    LP     P++M+GPG+G+APF+ FIE+R V    G    + V++FG R ++ DF +E++ K+  +   +S ++ AFSRDQ DKIYVQH + ++ +   IWD+IN+     Y+ G++K M  DV   L+ +F  +G M+ S+A+     ++   R+ ++ WS
Sbjct:    6 GKKRLTVLYGSQTGTAQEVAERIGREGRRRHISARVLALDDYNVADL-----IKEDLVVFVCATTGQGDEPDNMKKFWRFIMRRNLPAHSLQQLSFSVLGLGDSSYPKFNFIAKKLNKRLLQLGASVLQPVGLADDQHDLGPDAVVDPWLKELWEKV---FAVYPIPPGLEIISADERPPARY--KIIYTDSPAEESSLEFGLPA-SQQAPFFATLISNDRVTASNHWQDVRLVKLDISGSGISYSPGDVVMVQPSNLSDTAEEFMSFLHLDPDKNFTLQQTNPDIPVPRRLPRPCSIRFLVEHYLDIQGVPRRYFFELLSHFTPSELEKEKLQDFASAEGQEDLYSYCYRQKRSTLEVLQDFPQASANLPFEYLLDLIPAIQPRAFSIASAQKAHPDEIEILMAVVKYQTKISKPRRGLCSTWLS-SLPSRSR---VPVWVKRGTISLPLDHTVPLLMIGPGTGVAPFRSFIEERLVPVHEG---SKCVLFFGSRNKNADFFFENQWKELSETGCLS-VFTAFSRDQDDKIYVQHRIREQSSL--IWDLINNHRAICYLAGNSKRMPIDVKEALIEVF-CKGEMSESEAEALFAELERTRRYQAETWS 592          

Query:  324 LSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQ-EFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPAN--VPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKV-LVKQELCKGGDRSVMHIELDIT-NSRIKYESGDHVAVFPTNDPILVDKLAKRL--NINLDQVISMVAIDEDNSKRHPF------------PCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRN--MKGVCTHYLNMKNPSPSETPVVPIYVRRSQ-FRLPYKSKSPIIMVGPGSGIAPFKGFIEDRS---------VAK----SAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSD-KIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS*T 2162
             S   + K +      ++ Y ++TG +E +A  LA       L   A DP+   M+E  + +     L +   +T+G GDP +N +    N L +A+     +   +FGLG++ Y NF A  +  D+ + ELGA +IH+ G GD+ +  E+ F TW + ++ + C+ F + G+ +++      L   ++   P    +      L    K     + K    AKV  VK+       RS + ++LD +  +   Y  GDH++VFP N   LV  L  RL    + DQ I +    E + KR PF            P PTT R A   +IDI       +L  L+  AT+  + + L+ L   +G   Y +W  + + NI+ VLE+ PS+ V  + LL  LP LQ R+YSISSS    PN +H+T  ++ Y    G+     GVC+ + N   P      +VP +VR++  F LP     PIIMVGPG+GIAPF+ F + R          V K    + G   G+ V+YFGCR  + D +Y++E K AHQD  ++ +  A SR+    K YVQ L+ KE     I  ++  G H Y CGD   MA DV  T+  + +    MT  +AQ+++  +++ GR+  D++  T
Sbjct:  468 FSANLMGKAMAKRTKAIILYATETGKSESYARMLAD------LFLHAFDPKVMRMDEYPHPEMENEQLILIVTSTFGNGDPPENGEVSTINPLDSAS-QQRIIEDQMFGLGSRAYPNFCAFARSLDKIIQELGAEQIHKCGEGDELAGQEESFKTWAKQVFKAACDTFCV-GEMVNVAEADESLNTLSSGWSPGKYRFTSVKEELQDVCKSIASVNNKPIVGAKVKSVKKLQSADSSRSTILLKLDTSPAAEFHYNPGDHLSVFPCNRRELVQSLIDRLCEAPDPDQPIKLEVCQETSGKR-PFGKTKKWTPVDRLPTPTTVREAFSRFIDIAGTPTPQILKSLASLATNPKDREALETLG--KGDNHYDDWKYEKQSNIVEVLEEFPSVNVEAEMLLTQLPLLQPRFYSISSSQDFSPNEVHLTVAVVQYNKREGKGPVHYGVCSTWFNGLKPGD----IVPCFVRKAHSFHLPDDGSLPIIMVGPGTGIAPFRSFWQQRQYDIVKKPSPVPKPRDAAPGSGWGDMVLYFGCRCSTLDDIYQEETKTAHQDGALAAVRTALSREPGHVKQYVQDLL-KEDADAIIDKLVGQGAHLYTCGDVS-MAADVCRTIQKLLEEYAAMTQQEAQEFIDNLKSSGRYHEDIFGVT 1099          

Query:  366 NVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATV---NMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNI-NLDQVISMVAIDEDNSKRHP-----FPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDY--ITNTGRNMKGVCTHY-------------------LNMKNPSPSETPV--VPIYVRR-SQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPL---GETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWD-----IINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            +  + Y SQTG A+  A+ + +++   GL          + + +L     + S  +F ++T GEGDP D   +F+  L+  T+   ++  L+Y +  LG+  Y NF   GK  DRRL+ELGA + ++ G  DD   +E     W + +W  + +  G + D              + VP             +F     P        A+ L   +  K      + I LDI+ S  +YE+G+   ++  ND   VD + +RL + ++ QV   + +     K+        P P T + +LL  +DI    +   L  L E+  D +E   L+ L S +G  +Y  ++ +   ++L +L   PS   P + LLE LPRL  R YSISSSP   P  ++    ++ +    +  ++ KGVCT +                   L +   S   +P   VP+  R  S F+LP  S+ P+IM+GPG+G+APF GF+  R       + L   GE  ++FGCR + +DFLY+ EL+   +   +S L+ +FSRDQ   + +      + N K   D     ++N G   Y+CGDAK+MA +V      I +    +   +A   +  ++ + ++  DVW+
Sbjct:    6 SFTILYASQTGQAKAIADEIHEKSASNGLNSKLFCLSLTEKKFMLE----KESAVVFVVSTTGEGDPPDTMLKFFRRLKKKTLPGNHLKDLQYGLLALGDSNYTNFCVNGKNLDRRLNELGAKKFYDTGHADDAVGLELVVEPWIDGLWGPLKDILGKTPDF-------------STVPHQAG--------ASFPGAASPITMATIVGARRLTADDAMK----KALEITLDISQSGWEYEAGNSFNIYCPNDEGEVDAIIERLGLTSMAQVPYDIQVMSGTKKKTASIPNYIPQPYTIKESLLTCLDIRMVPRKAFLRTLVEFTHDNNEQRRLQELCSKQGADEYCRFVREPSLSLLELLTAFPSCFPPFERLLEHLPRLSPRPYSISSSPLEKPGQLNFVFNVVKFGEFEDIRKSRKGVCTSWLEGLTGSMITEEGNKANGILKISELSILSSPYVQVPVSARSNSDFKLPPDSRIPVIMIGPGTGVAPFIGFLHHRRKQMELAEDLTGFGEMWLFFGCRHREKDFLYQKELESFVETGTLSRLFTSFSRDQGFTVSLSTPRYVQDNLKLQGDKIADLVLNDGAVVYVCGDAKNMASNVFECFCEIIEKHLCVGKMEAIKEMTRLRKERKYREDVWT 614          

Query:  246 SKTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQ-NATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNL--SSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINS-GGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            S+ + E I E F  + +P     ++S    FIEKM K GKN++VFYGSQTGTAE+FANRL+K+A RYG+KGMAADPEE  M EL  +  I+NSLAIFCMATYGEGDPTDNAQ+FY+WLQ N   +++GL YTVF LGNKTYE++NAMGKY D+RL ELGA RI +LG+GDDDSN+E+ F++W+E  W +VC HFG+     ++++RQY L+L  +V  NK++ GE+ RL +FE Q+PPFDAKNPFLA V V + L K GDR +MH+ELDIT S+++YESGDHVAVFPTND  LV++L + L ++LD VIS+  +DE+++K+HPFPCPTTYRTAL HY+DI NP +TNVL +L++YA++  + + ++ +  SS EGK  YQ W+LDS RNILA+LED+PSLK P DHL ELLPRLQ RYYSI+SS K++PN+IHI AV+++Y T TGR  KGV T++L  K  +  ++  VP+++R+SQFRLP+K+ +P+IM+GPG+GIAPF GFI++R   K  GK +GETV+YFGCR ++ED++Y++EL+ A +  V++ L +AFSRDQ  K+YVQHL+  +KN++ +W +I++   H Y+CGDA++MAKDV   L  I +   GMT +QA DY+K +  KGR+S DVWS
Sbjct:   38 SRKKPEPIPE-FKKIDTPQVSQRETS----FIEKMKKTGKNIIVFYGSQTGTAEEFANRLSKDAQRYGMKGMAADPEEYTMGELARMSEIKNSLAIFCMATYGEGDPTDNAQDFYDWLQENDDEDLSGLNYTVFALGNKTYEHYNAMGKYVDKRLEELGAKRIFDLGLGDDDSNLEEDFVSWREQFWPAVCEHFGVEASADELSIRQYELKLHNDVNMNKVFTGEIGRLKSFEVQKPPFDAKNPFLAPVTVNRRLNKAGDRHLMHLELDITGSKLRYESGDHVAVFPTNDSALVNRLGEILGVDLDVVISLNNLDEESNKKHPFPCPTTYRTALTHYLDIMNPPRTNVLYELAQYASEPKDQENMRKMASSSPEGKALYQTWVLDSCRNILAILEDMPSLKPPVDHLCELLPRLQARYYSIASSSKVHPNSIHICAVVVEYSTKTGRVNKGVATNWLKNKLVNGHKS-TVPMFIRKSQFRLPFKATNPVIMIGPGTGIAPFMGFIQERGWLKEQGKEVGETVLYFGCRHKNEDYIYQEELEDAEKSGVLTQLNVAFSRDQDHKVYVQHLL--KKNKEHVWKLIHTDNAHLYVCGDARNMAKDVQTALYEIAEELEGMTRTQATDYIKKLMTKGRYSQDVWS 670          

Query:  366 NVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATV---NMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFIT--WKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGD-RSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNS---KRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLP--SLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIIN-SGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            +++V YGSQTGTA+D A R+ ++A R  L       +   + +L     I  SL +F  +T G+G+P DN + F+ +L   ++   +++ L   V GLG+ +Y  FN + K   +RL +LGA  +  +G+GDD  ++    +   W    W SV     +      +   +    LP     + +  GE  R    E+ R       PF A+++  + + +    + V HIE D+T S +++ +GD V + P N    V +    L + LD   + +     NS    R P PC   +      Y+DI    + +    L+ +ATD+ E D L   SS  G+ +   +    RR  L VL D P  + ++  D+LL+L P +Q R +SI+SS K +P+ + I   ++ + T   +  +G+C+ +L   +P   E   VP++V+      P  + +P+IMVGPG+G+APF+  +++R             V++FGCR +S+DFL+  E +   +   ++ L+ AFSRDQ +K+YVQ  +   +N   +W++I+     FYI G+AK M   V ++L  +FQ EGG++   A   L  M+   R  S+ WS
Sbjct:   54 SLLVLYGSQTGTAQDAAQRIGRQAQRRRLPVRVMALDSYAVADL-----IAESLVVFVCSTAGQGEPPDNMKNFWRFLFRKSLPGGSLSRLDCAVLGLGDSSYPKFNFVAKKLHKRLLQLGANMLMPVGLGDDQHDVGPDAVVDPWLASFWGSV---LALYPSLTSVTPLREDERLPPTFTFHFLV-GE--RESGDERLRVSEGEAGPFRARMVFNRRVTEPSHFQDVRHIEFDVTGSSMRFAAGDVVMMRPRNAAEDVQQFC--LLLGLDPDATFLLEPTSNSPVPARLPRPCSVQHLVE--SYLDIAAVPRRSFFELLATFATDELERDKLVEFSSAAGQDELNSYCSRPRRTALEVLADFPQTTAELKVDYLLDLFPEIQPRSFSIASSLKAHPHRLQILVAVVRFQTKLQKPRRGLCSSWLASLDPEKGEV-CVPLWVKGGSLTFPADADTPVIMVGPGTGVAPFRAALQERLCEGRTAN-----VLFFGCRSESKDFLFRSEWELMVEAGGLT-LFTAFSRDQEEKVYVQRRV--RENAALLWELISRRKACFYIAGNAKQMPASVCDSLKEVFQQEGGVSADAAAQMLAAMEKTSRLQSETWS 638          

Query:  318 SSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQN------------------------------------------ATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLG---AFEKQRPPFDAKNPFLAKVLVKQEL-CKGGDRSVMHIELDITN-SRIKYESGDHVAVFPTNDPILVDKLAKRLN--INLDQVISMVAIDEDNSK-----------RHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRN--MKGVCTHYLNMKNPSPSETPVVPIYVRRS-QFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSV-AKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSD-KIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVW 2153
            + L G  + K VK      + + ++TG ++D+A  L  E  ++         +E D+ +L +      +L +   +T+G GDP +N ++F   L                                            +T  +  +R++VFGLG++ Y +F A     D    ELG  RI  +G GD+    E+ F TW + ++ + C+ F + GD  D+N+ +    L +N    K  K  +T +       +       +  + AK++  Q L     +RS + + L   N  ++ Y+ GDH+ +FP N   LV  L  +L     ++Q++ +  ++E N+            R P   P T   A  +++DI  P    +L   +  AT++ E   L+ LS  +G  +Y+EW   +   ++ VLE+ PS+++P+  LL  LP LQ RYYSISSSP  YP  IH+T  ++ Y T  G      GVC+ +LN       +  +VP +VR +  F+LP   ++P I+VGPG+GIAPF+ F + R    +  G      ++ FGCR+   D +Y++E  +A    V  +LY A+SR+    K YVQ ++ +  +      +   GGH Y+CGD   MA DV  T+  I + +G M+   A  Y+  ++++ R+  D++
Sbjct:  744 AKLMGQAMAKRVKA----TILFATETGKSQDYAKTLC-EIFKHAFDAKVMSMDEYDVVDLEH-----ETLVLVVTSTFGNGDPPENGEKFGAALMEMRHPTSNTEDRKSYKVRFNSVSSYSDTRKSSSDEPETKINFESTGPLANVRFSVFGLGSRAYPHFCAFAHAVDTLFEELGGERILRMGEGDELCGQEESFRTWAKKVFKAACDVFCV-GD--DVNIEKANDSLISNDRSWKKSKFRMTYMAESPVLTEGLYSIHKRKVYGAKMIESQNLQSPKSNRSTIFVRLHTNNHDKLSYKPGDHLGIFPGNHEDLVTALIDKLEDAPPVNQIVKVEFLEERNTALGVISNWTHETRIP---PCTIYQAFQYFLDITTPPTPVLLQQFAALATNEKEKRKLEILS--KGLQEYEEWKWYNNPTLVEVLEEFPSIQMPSTLLLTQLPLLQARYYSISSSPDTYPGEIHLTVAVVSYRTRDGGGPIHHGVCSSWLNRIE----KGEMVPCFVRSAPSFQLPKDDQAPCILVGPGTGIAPFRSFWQHRLYNLEHNGIKSCPMILVFGCRQSEMDHIYKEETLQAKNKGVFKELYTAYSREPGKPKKYVQDVLREHLSEMVYQCLKKEGGHIYVCGDVT-MAGDVLKTVQQIVKQQGNMSLEDAGFYISKLRDENRYHEDIF 1397          

Query:  318 SSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQ-------------------------------------------------EFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLG---AFEKQRPPFDAKNPFLAKVLVKQEL-CKGGDRSVMHIELDITN-SRIKYESGDHVAVFPTNDPILVDKLAKRLN--INLDQVISMVAIDEDNSK-----------RHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRN--MKGVCTHYLNMKNPSPSETPVVPIYVRRS-QFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSV-AKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSD-KIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVW 2153
            + L G  + K VK      + + ++TG ++D+A  L  E  ++         +E D+ +L +      +L +   +T+G GDP +N +                                                 E    L N  V    +R++VFGLG++ Y +F A     D    ELG  RI  +G GD+    E+ F TW + ++ + C+ F + GD  D+N+ +    L +N    K  K  +T +       +       +  + AK++  Q L     +RS + + L   N  ++ Y+ GDH+ +FP N   LV  L  +L     ++Q++ +  ++E N+            R P   P T   A  +++DI  P    +L   +  AT++ E   L+ LS  +G  +Y+EW   +   ++ VLE+ PS+++P+  LL  LP LQ RYYSISSSP  YP  IH+T  ++ Y T  G      GVC+ +LN       +  +VP +VR +  F+LP   ++P I+VGPG+GIAPF+ F + R    +  G      ++ FGCR+   D +Y++E  +A    V  +LY A+SR+    K YVQ ++ +  +      +   GGH Y+CGD   MA DV  T+  I + +G M+   A  Y+  ++++ R+  D++
Sbjct:  744 AKLMGQAMAKRVKA----TILFATETGKSQDYAKTLC-EIFKHAFDAKVMSMDEYDVVDLEH-----ETLVLVVTSTFGNGDPPENGEKFGAALMEMRHPTSNTEDRKSYKVRFNSVSSYSDTRKSSSDEPETKINFESTGPLANVRVRSAAVRFSVFGLGSRAYPHFCAFAHAVDTLFEELGGERILRMGEGDELCGQEESFRTWAKKVFKAACDVFCV-GD--DVNIEKANDSLISNDRSWKKSKFRMTYMAESPVLTEGLYSIHKRKVYGAKMIESQNLQSPKSNRSTIFVRLHTNNHDKLSYKPGDHLGIFPGNHEDLVTALIDKLEDAPPVNQIVKVEFLEERNTALGVISNWTHETRIP---PCTIYQAFQYFLDITTPPTPVLLQQFAALATNEKEKRKLEILS--KGLQEYEEWKWYNNPTLVEVLEEFPSIQMPSTLLLTQLPLLQARYYSISSSPDTYPGEIHLTVAVVSYRTRDGGGPIHHGVCSSWLNRIE----KGEMVPCFVRSAPSFQLPKDDQAPCILVGPGTGIAPFRSFWQHRLYNLEHNGIKSCPMILVFGCRQSEMDHIYKEETLQAKNKGVFKELYTAYSREPGKPKKYVQDVLREHLSEMVYQCLKKEGGHIYVCGDVT-MAGDVLKTVQQIVKQQGNMSLEDAGFYISKLRDENRYHEDIF 1404          

Query:  966 KNPFLAKVLVKQELCKGGD--RSVMHIELDI-TNSRIKYESGDHVAVFPTNDPILVDKLAKRLNIN--LDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYI-----DINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGR--NMKGVCTHYL-NMKNP------------SPSETPVVPIYVRRS-QFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKP--LGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRD----------QSDKIYVQHLMAKEKNRKQIWDII-NSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            K  F    + K  L   GD  ++ + +ELDI T   + Y+ GD + V   N    VD +  RL +    D  +  VA+ +D  K+     P   +   L ++     +I +  K   L  L EYA D ++   L+ L S +G   Y   + D+  +++ +L    S   P   L+E LP+LQ R YS +SS   +P  +H    +++     GR    +G+CT +L ++ +P            SP+    + + +R S  FR P +   P IMVGPG+G+APF GF++ R  A+        GET ++FGCR ++ D+L+ +EL+       +S L + FSRD           ++  YVQH +     R+Q+ DI+    G FY+CGDAK+MAKDVN TL+ I +TE  +   +A   L  ++ K R+  D+W+
Sbjct:  295 KETFHEVPISKAVLLSRGDSVKTALLLELDISTCPALTYQPGDSLDVLCPNRAEEVDYMLCRLGLKDRRDHRVH-VALRKDTKKKGAHVPPHIPQNVSLLFLFTWCLEIRSVPKKAFLRALVEYAADGTQKRRLQELCSKQGAADYNLHVRDASLSVVELLTAFSSCSPPLSLLIEHLPKLQPRPYSAASSCLRHPGKLHFVFSVVELPACFGRPAGRRGLCTGWLFDLIHPGIVFPGKTESSSSPAPAKAIHVSLRPSCSFRPPSEQSVPFIMVGPGTGVAPFIGFLQQREEARKRNPEAVFGETWLFFGCRHRNGDYLFREELEGFVASGTLSHLKVCFSRDGREAEEAVASAANPRYVQHNLLL--YRQQVADILLRQSGCFYVCGDAKNMAKDVNETLMEIIKTELHVDQLEAMKKLAELREKKRYLQDIWA 727          

Query:  372 VVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQ--NATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSV 812
            VV YGSQ G A+  A  +A+EA  +GL    A+    + +E  NL+  E +  +F ++T G+G+P DNA +F   +    +  +   L YT+  LG+  Y NF   GK  +RRL  LGA + +  G  DD   +E     W E +W +V
Sbjct:   10 VVLYGSQKGQAQSIAEGIAEEAEDHGL---VAELSCLNQDEKYNLEK-EIAPVVFVVSTTGDGEPPDNALQFVKRINKNQSPDHYKHLSYTLLALGDTNYANFCNCGKTIERRLQALGARQFYPAGFADDGVGLELVVDPWLEGLWKAV 154          

Query:   96 MDISNSETVPEPINSYGFPGFSLTSLSTIDXXXXXXXXXXXXXXXXXRRKSKTEEENISENFTLLKSPAKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            MDISNSETVPEPINSYG PGFSLTSLSTIDIFILISFFVFLVFFLFSRRKSKTEEENISENFTLLKSP+KLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRYYSISSSPKIYPNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS
Sbjct:    1 MDISNSETVPEPINSYGLPGFSLTSLSTIDIFILISFFVFLVFFLFSRRKSKTEEENISENFTLLKSPSKLTTQSSLSGGFIEKMVKGGKNVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVNMNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCKGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRYYSISSSPKIYPNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 687          

Query:  366 NVVVFYGSQTGTAEDFANRLAKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVN--MNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSN--IEDHFITWKEDMWTSVCNHFGISGDKIDINVRQYRLELPANVPENKIYKGEVTRLGAFEKQRPPFDAKNPFLAKVLVKQELCK-GGDRSVMHIELDIT--------------NSRIKYESGDHVAVFPTNDPILVDKLAKRLNINLDQVISMVAIDEDNSKRHPFPCPTTYRTALLHY-------IDINNPLKTNVLGDLSEYATDKSEADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLP--SLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYLNMKNPSPSETPVVPIYVRRSQFRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQSDKIYVQHLMAKEKNRKQIWDIINS-GGHFYICGDAKHMAKDVNNTLLNIFQTEGGMTNSQAQDYLKMMQNKGRHSSDVWS 2156
            N+ +FYGSQTG A+D A ++ +      L    A  +  +M ++      +N + IF  +T G+GDP DN + F+  +   + N  ++ L + VFGLG+  Y  +N + K   RRL +L A  +  +G+ DD  +  I+  F  W + +W        +  D+++      +     N+ EN      + +     K     + K            LC  G D   +   + +T              N  +KY+ GD ++++P N  I VD   +  N+  + ++++        +   F  P+ + +  L +       +D+N+  + +     +  + DK E + L+ LS  E   +   +    +R I+ VL+D P  S  +     + L+P ++ R YSI+SS  ++   I +    + Y T    +  G+C+++L    PS     +V   +++   + P  S  P+I++ PG+GIA F+G+I +R +A +    +G T++ FG R ++ DF +  E K   ++N    L  AFSR++  K+Y+Q  + ++   + IW II    G  +I G +  M + V+N + NI   EGG++  +A + L +M+   R+  + WS
Sbjct:    3 NLKIFYGSQTGNAQDVAEKVYR--FSQNLPPKYASVKIGEMNDVAFDSLSQNDIFIFICSTTGQGDPPDNMKHFWQCVMKRSFNPNLSCLDFAVFGLGDSKYNKYNFIAKKLYRRLIQLKANSMINIGLADDQHSLGIDGEFSLWIKLLWK-------VLEDRLN------KFITVKNLFENCYTNAILEKYNIVVKDNGCLNGKLQTTNSNYDISSLCPLGYDVFTVKYNVPMTPISHFQDTRLIAFDNKNLKYDVGDVLSIYPQNSKIEVDLFFELTNLCRNTLLTI-------KRNLNFKIPSIFVSNSLSFENIVYYGLDLNSVPRKSFFEHFAFISDDKVEKERLQELSDAENIDELYSYCFQPKRTIIEVLQDFPNTSKYINISQWINLIPFIRPRDYSIASSNVVHNGEIQVLVSRVKYKTKMFNSRIGLCSNFLCDLKPSD----IVFSRIKKGTLKFP-DSYFPLILISPGTGIAAFRGYISERMLANN----IGRTLLCFGSRYKNRDFYFASEFKSFCKNNNFK-LLTAFSREE--KVYIQDKLKEQS--ELIWKIIKEPSGFLFISGRSVDMPQQVHNEIKNIIIKEGGISEKEAANILNVMEKHKRYQIETWS 592          

Query:  372 VVFYGSQTGTAEDFANRL---AKEAVRYGLKGMAADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVN-MNGLRYTVFGLGNKTYENFNAMGKYFDRRLSELGATRIHELGIGDDDSNIEDHFITWKEDMW---TSVCNHFGISG----------DKIDIN-VRQYR---------------LELPANVPE---NKIYKGEVTRLGAFEKQRPPFDAKNPFLAK--VLVKQELC-------KGGDRSVMHIELDITNSRIKYESGDHVAVFPTNDPILVDKLAKRLNI---NLDQVISMVAIDEDNSKRHPFP--------CPTTYRTALLHYIDINNPLKTNVLGDLSEYATDKS-EADFLKNLSSIEGKIKYQEWILDSRRNILAVLEDLPSLKVPTDHLLELLPRLQVRXXXXXXXXXXXXNTIHITAVLLDYITNTGRNMKGVCTHYL-NMKNPSPSETPVVPIYVRRSQ--FRLPYKSKSPIIMVGPGSGIAPFKGFIEDRSVAKSAGKPLGETVMYFGCRKQSEDFLYEDELKKAHQDNVISDLYLAFSRDQ--------------SDKIYVQHLMAKEKNRKQIWDIINSGGHFYICGDAKHMAKDVNNTLLNIF--QTEGGMTNSQAQDYLKMMQNKGRHSSDVW 2153
             + YGSQTG A+  A  L    K+ +++       D E+C     LN        AI   +T G+GD  DNA +F   ++      ++  +YTV GLG+  Y NF    K  D+ L   GA R +   + DD   +E     W + ++     +C+   I G           KI+I  +  Y+               L +PA +P    N IY  E     +      P     P  +    LV  E+        K   +SV    +++ N++ K++ GD V + P N    VD +  RL +     +  + +  ++   ++R   P           + ++ LL   D+  PL    L  +SEY   KS E   L  L S EG+  Y + + ++   +L +L   PS ++P   LLE+LPRL+ R YS+     +      +    +   T   R + GVCT ++  M N    +   +PIY+R++   F +      P I++GPG+G+APF GF++     K+  + +G   ++FGCR +  DF+++ +L+      +++ L + FSRD                +  YVQH +    N      ++N     ++CGD+  M+KDV  T  N+     E   T   A  ++  M+ +  +  DVW
Sbjct:    3 CILYGSQTGQAKSIAENLYAKLKDYIKHINIFELDDVEKCFEIHKLNF-------AIIICSTTGDGDAPDNASKFLRLIKIYQPKYLSNFKYTVLGLGDTNYSNFCNCSKTIDQILESKGARRFYRSDMADDAVGLEIVVEPWLDGLYEIAKDMCSEIPIDGFQNLSITEKISKIEIKPIENYKELLGDHLAKDMDGKNLTVPA-LPSPFLNIIYNNE----DSISNFHEPLITSMPMPSSDSELVMGEIQDITKITNKYAIKSVHRATINVPNAKWKWKPGDSVGILPCNAESEVDSILSRLFVPETEKNCAVRLELLENLENRRAKVPEHLIVRENGKMSLKSILLWLCDLRQPLSKVGLRIMSEYCPMKSAEQRRLLELCSREGQSFYTKCLRETSMPVLDLLNWFPSCQIPIVRLLEVLPRLKPRAYSLCDLESVSFAFSKVDIAPIQ--TFRKRPLTGVCTSWMEKMANFHNEQIWKIPIYLRKNMNGFTVCENPSIPHILIGPGTGVAPFIGFLQYFEKLKNENQNIGPIWLFFGCRNEERDFIFKKQLEHFANSGILTHLCVCFSRDNPTNSGDEQKNFCQPPNCKYVQHCLLHHSNILSDL-LVNQNARVFVCGDSSGMSKDVLETWSNVLLGNHEKIQTKRDADSFITGMRVQKLYLEDVW 657          

Query:  369 VVVFYGSQTGTAEDFANRLAKEAVR--YGLKGM---AADPEECDMEELLNLKSIENSLAIFCMATYGEGDPTDNAQEFYNWLQNATVN-------MNGLRYTVFGLGNKTYE-NFNAMGKYFDRRLSELGATRIHELGIGDD------DSNIEDHFITWKEDMWTSV 812
            + + YGS TG ++  A + +KE +   Y  K M     DPEE       NL   E SL +  ++TY  G P ++A+ FYNWL +A  +       +  L++ V GLG+  YE NFN + K  D     L   R+ E+GI D+      +  ++  +  W +  W ++
Sbjct:   23 IKILYGSLTGKSKILAEKFSKECIHNNYDFKMMNMNTYDPEE-------NLNK-EKSLLVIFVSTYENGTPPEDAKWFYNWLIDAKDDFRVDKNFLENLQFAVVGLGSSYYESNFNVVSKAIDEAFWSLSGKRLLEIGICDENVVNSKNGGLDYDYQEWSKKFWKTL 181