LRP2-binding protein

Overview
NameLRP2-binding protein
Smed IDSMED30025729
Length (bp)1213
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of LRP2-binding protein (SMED30025729) t-SNE clustered cells

Violin plots show distribution of expression levels for LRP2-binding protein (SMED30025729) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of LRP2-binding protein (SMED30025729) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for LRP2-binding protein (SMED30025729) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30025729

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30025729SMESG000066814.1 SmedASXL_001043SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of LRP2-binding protein vs. Ensembl Human
Match: LRP2BP (LRP2 binding protein [Source:HGNC Symbol;Acc:HGNC:25434])

HSP 1 Score: 234.187 bits (596), Expect = 2.819e-73
Identity = 142/328 (43.29%), Postives = 189/328 (57.62%), Query Frame = 2 
Query:   74 LPTNIPIEQVSFDAALIKELKVLDIIKPHRKCVHMLKINNNLEIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDNIGDS----------SDSMRKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKS 1027
            LP N     VS  AA  K  K     K      H   ++  L++ L++RI KG   A F  GQL F    YE+A+  F     K KD Q  YQ+GV+YYDGL   +DAE    YMK+IL     P+ARHL +AAA+NLGRAYY G GVK+S E+A   WL AAD+G+P ASV AQ+MLG +Y  +E  ++ KA +WHSEAC NG+ +SQ  LG+MY  G G + D  AAL CLR A+ERG +YAQG L  YYY  K +      + R+  A  D + D            + + +G+A+A F +ARCL LG G+ ++   ++ Y  K+
Sbjct:    8 LPKNPFYASVSQYAA--KNQKFFQWKKEKTDYTHANLVDKALQL-LKERILKGDTLAYFLRGQLYFEEGWYEEALEQFE--EIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKKIL-DSPCPKARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKASVKAQSMLGLYYSTKEPKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYKMKFFTKCVAFSKRI--ADYDEVHDIPMIAQVTDCLPEFIGRGMAMASFYHARCLQLGLGITRDETTAKHYYSKA 327
[Close]
BLAST of LRP2-binding protein vs. Ensembl Human
Match: LRP2BP (LRP2 binding protein [Source:HGNC Symbol;Acc:HGNC:25434])

HSP 1 Score: 234.187 bits (596), Expect = 2.819e-73
Identity = 142/328 (43.29%), Postives = 189/328 (57.62%), Query Frame = 2 
Query:   74 LPTNIPIEQVSFDAALIKELKVLDIIKPHRKCVHMLKINNNLEIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDNIGDS----------SDSMRKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKS 1027
            LP N     VS  AA  K  K     K      H   ++  L++ L++RI KG   A F  GQL F    YE+A+  F     K KD Q  YQ+GV+YYDGL   +DAE    YMK+IL     P+ARHL +AAA+NLGRAYY G GVK+S E+A   WL AAD+G+P ASV AQ+MLG +Y  +E  ++ KA +WHSEAC NG+ +SQ  LG+MY  G G + D  AAL CLR A+ERG +YAQG L  YYY  K +      + R+  A  D + D            + + +G+A+A F +ARCL LG G+ ++   ++ Y  K+
Sbjct:    8 LPKNPFYASVSQYAA--KNQKFFQWKKEKTDYTHANLVDKALQL-LKERILKGDTLAYFLRGQLYFEEGWYEEALEQFE--EIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKKIL-DSPCPKARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKASVKAQSMLGLYYSTKEPKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYKMKFFTKCVAFSKRI--ADYDEVHDIPMIAQVTDCLPEFIGRGMAMASFYHARCLQLGLGITRDETTAKHYYSKA 327
[Close]
BLAST of LRP2-binding protein vs. Ensembl Human
Match: LRP2BP (LRP2 binding protein [Source:HGNC Symbol;Acc:HGNC:25434])

HSP 1 Score: 232.261 bits (591), Expect = 6.676e-73
Identity = 134/297 (45.12%), Postives = 178/297 (59.93%), Query Frame = 2 
Query:  206 ILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNA-------AD--------LAARVISAAPDNIGDSSDSMRKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEIS 1051
            +L++RI KG   A F  GQL F    YE+A+  F     K KD Q  YQ+GV+YYDGL   +DAE    YMK+IL     P+ARHL +AAA+NLGRAYY G GVK+S E+A   WL AAD+G+P ASV AQ+MLG +Y  +E  ++ KA +WHSEAC NG+ +SQ  LG+MY  G G + D  AAL CLR A+ERG +YAQG L  YYY  K +          AD        + A+V    P+ IG       +G+A+A F +ARCL LG G+ ++   ++ Y  K+   N  ++
Sbjct:   23 LLKERILKGDTLAYFLRGQLYFEEGWYEEALEQFE--EIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKKIL-DSPCPKARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKASVKAQSMLGLYYSTKEPKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYKMKFFTKCVAFSKRIADYDEVHDIPMIAQVTDCLPEFIG-------RGMAMASFYHARCLQLGLGITRDETTAKHYYSKACRLNPALA 309
[Close]
BLAST of LRP2-binding protein vs. Ensembl Human
Match: LRP2BP (LRP2 binding protein [Source:HGNC Symbol;Acc:HGNC:25434])

HSP 1 Score: 98.5969 bits (244), Expect = 5.467e-24
Identity = 68/152 (44.74%), Postives = 84/152 (55.26%), Query Frame = 2 
Query:   71 SLPTNIPIEQVSFDAALIKELKVLDIIKPHRKCVHMLKINNNLEIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQS 526
             LP N     VS  AA  K  K     K      H   ++  L++ L++RI KG   A F  GQL F    YE+A+    F   K KD Q  YQ+GV+YYDGL   +DAE    YMK+IL     P+ARHL +AAA+NLGRAYY G GVK+S
Sbjct:    7 KLPKNPFYASVSQYAA--KNQKFFQWKKEKTDYTHANLVDKALQL-LKERILKGDTLAYFLRGQLYFEEGWYEEALE--QFEEIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKKIL-DSPCPKARHLKFAAAYNLGRAYYEGKGVKRS 152
[Close]
BLAST of LRP2-binding protein vs. Ensembl Human
Match: SEL1L (SEL1L adaptor subunit of ERAD E3 ubiquitin ligase [Source:HGNC Symbol;Acc:HGNC:10717])

HSP 1 Score: 54.6842 bits (130), Expect = 2.405e-7
Identity = 63/204 (30.88%), Postives = 91/204 (44.61%), Query Frame = 2 
Query:  203 IILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFG-VKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAK--AIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYA 805
            ++ R R+   ++      G L       ED I Y+ F A K  D+Q    +G L+  G +      +   + +   YF     A +  +A AF LG+ Y  G   V QS E AL Y+  AAD G+PV     Q+ LG  Y +   + +    A+ +  +A   G    Q  LG MY+ GIG K D+  AL     AS+ G I A
Sbjct:  336 VVQRIRLPDEVENPGMNSGML------EEDLIQYYQFLAEK-GDVQAQVGLGQLHLHGGRG-----VEQNHQRAFDYFNLAANAGN-SHAMAF-LGKMYSEGSDIVPQSNETALHYFKKAADMGNPVG----QSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILA 521
[Close]
BLAST of LRP2-binding protein vs. Ensembl Zebrafish
Match: lrp2bp (LRP2 binding protein [Source:NCBI gene;Acc:100073340])

HSP 1 Score: 219.935 bits (559), Expect = 5.630e-68
Identity = 123/268 (45.90%), Postives = 165/268 (61.57%), Query Frame = 2 
Query:  206 ILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVIS-AAPDNIGDSSDSM----RKGLALAYFIYARCLNLGFGVQKN 994
            +L+++ + G  +A F  GQL ++   Y +A   F+    K KD Q +YQ+ V+YYDGL  + D   A  YM ++ ++ +  EA  + YAA +NLG+AY  GFGV+ S  +A   WL AADDG+P ASV AQ+ LG FY   E LD+ KA FWHS+AC NGS +SQA LG+MY  G G + D  +AL CL+ A+ERG +YAQG L   YY R+LY  AA L  RV        I   +D +    RKG+A+  F YARCL+LG GV +N
Sbjct:   48 LLKEKAETGDSQATFLLGQLHYVQGCYAEAELIFD--RIKDKDPQALYQLAVIYYDGLGTKEDLGRAVEYMGRVAFW-DSSEAGSVRYAALYNLGQAYLEGFGVQASSSEAERLWLLAADDGNPNASVKAQSALGMFYSRPESLDLRKAFFWHSQACGNGSLESQAALGLMYLYGHGVQRDSDSALFCLKEAAERGSVYAQGHLTACYYRRQLYSRAAALGQRVCEYKDTAAIAQQTDCLEEYVRKGIAIGMFYYARCLHLGRGVPQN 312
[Close]
BLAST of LRP2-binding protein vs. Ensembl Zebrafish
Match: sel1l (SEL1L adaptor subunit of ERAD E3 ubiquitin ligase [Source:ZFIN;Acc:ZDB-GENE-041001-122])

HSP 1 Score: 55.0694 bits (131), Expect = 1.025e-7
Identity = 58/178 (32.58%), Postives = 84/178 (47.19%), Query Frame = 2 
Query:  281 MYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFG-VKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIA--KAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYA 805
            + ED I Y+ F A K  D+Q    +G L+  G +      +   + +   YF +   A +  +A AF LG+ Y  G   V Q+ E AL Y+  AAD G+PV     Q+ LG  Y +   + +    A+ +  +A   G    Q  LG MY+ GIG K D+  AL     AS+ G I A
Sbjct:  339 LEEDLIQYYQFLAEK-GDVQAQVGLGQLHLHGGR-----GVEQNHQRAYEYFNQAANAGN-THAMAF-LGKMYSEGSEYVPQNNETALHYFKKAADLGNPVG----QSGLGMAYLYGRGVPVNYDLALKYFQKAAEQGWVDGQLQLGTMYYNGIGVKRDYKQALKFFNLASQAGHILA 504
[Close]
BLAST of LRP2-binding protein vs. Ensembl Xenopus
Match: lrp2bp (LRP2 binding protein [Source:NCBI gene;Acc:100145071])

HSP 1 Score: 243.047 bits (619), Expect = 4.532e-77
Identity = 133/282 (47.16%), Postives = 182/282 (64.54%), Query Frame = 2 
Query:  200 EIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDNIG---DSSDSMR----KGLALAYFIYARCLNLGFGVQKNACLS-QLYSK 1021
            E  L+ RIK+G  +A F  GQL F    YEDA+    F   K +D Q +YQ GV+YYDGL  Q D      YM++I+   + P  +HL YAAA+NLGRAY+ G+GV+ S   A  +WLFAAD+G+P AS+ AQ+MLG +Y    ++D+ KA FWHSEAC NGS +SQ  LGVMY  G G K +  AA+ CL+ A+ERG +YAQG L   YY RKLY  A +LA +++  A DNI    ++++ +     KG+A+A F  ARCL+LG  +++++  + QLYSK
Sbjct:   44 ETFLKSRIKEGDVQANFFLGQLFFEEGWYEDAL--LQFEKVKEEDDQALYQAGVMYYDGLGTQEDHRKGVRYMERIV-TSDSPSVKHLKYAAAYNLGRAYFEGYGVRHSDRDAERWWLFAADNGNPKASLKAQSMLGMYYSSPPNVDLHKAFFWHSEACGNGSLESQGALGVMYLYGQGIKKNVQAAMECLKEAAERGNVYAQGHLVSCYYQRKLYTKAVELAKKIV--AHDNIELLVNATECLPSYTVKGVAMATFYLARCLHLGLAIEQDSTAAKQLYSK 320
[Close]
BLAST of LRP2-binding protein vs. Ensembl Xenopus
Match: lrp2bp (LRP2 binding protein [Source:NCBI gene;Acc:100145071])

HSP 1 Score: 243.432 bits (620), Expect = 5.513e-77
Identity = 137/301 (45.51%), Postives = 190/301 (63.12%), Query Frame = 2 
Query:  200 EIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDNIG---DSSDSMR----KGLALAYFIYARCLNLGFGVQKNACLS-QLYSKKSY-AWNVEISLYFKQLVG 1075
            E  L+ RIK+G  +A F  GQL F    YEDA+    F   K +D Q +YQ GV+YYDGL  Q D      YM++I+   + P  +HL YAAA+NLGRAY+ G+GV+ S   A  +WLFAAD+G+P AS+ AQ+MLG +Y    ++D+ KA FWHSEAC NGS +SQ  LGVMY  G G K +  AA+ CL+ A+ERG +YAQG L   YY RKLY  A +LA +++  A DNI    ++++ +     KG+A+A F  ARCL+LG  +++++  + QLYSK +     V   L+F+ + G
Sbjct:   44 ETFLKSRIKEGDVQANFFLGQLFFEEGWYEDAL--LQFEKVKEEDDQALYQAGVMYYDGLGTQEDHRKGVRYMERIV-TSDSPSVKHLKYAAAYNLGRAYFEGYGVRHSDRDAERWWLFAADNGNPKASLKAQSMLGMYYSSPPNVDLHKAFFWHSEACGNGSLESQGALGVMYLYGQGIKKNVQAAMECLKEAAERGNVYAQGHLVSCYYQRKLYTKAVELAKKIV--AHDNIELLVNATECLPSYTVKGVAMATFYLARCLHLGLAIEQDSTAAKQLYSKAAQLDATVAAELHFEMVYG 339
[Close]
BLAST of LRP2-binding protein vs. Ensembl Xenopus
Match: ampd3 (adenosine monophosphate deaminase 3 [Source:Xenbase;Acc:XB-GENE-984137])

HSP 1 Score: 57.3806 bits (137), Expect = 2.710e-8
Identity = 64/204 (31.37%), Postives = 93/204 (45.59%), Query Frame = 2 
Query:  203 IILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGF-GVKQSVEKALEYWLFAADDGSPVASVYAQTMLG--FFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYA 805
            ++ R R+   ++      G L       ED I Y+ F A K  D+Q    +G L+  G +      +   + +   YF +   A +  +A AF LG+ Y  G   V QS E AL+Y+  AAD G+PV     Q+ LG  + Y     +D   A+ +  +A   G    Q  LG MY+ GIG K D+  AL     AS+ G I A
Sbjct:  194 VVQRIRLADEVENPGMASGML------EEDLIQYYQFLAEK-GDVQAQVGLGQLHLHGGR-----GVEQNHQRAFEYFNQAANAGN-SHAMAF-LGKMYSEGSDTVIQSNETALQYFRKAADMGNPVG----QSGLGMAYLYGRGVPVDYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKKDYKQALKYFNLASQGGHILA 379
[Close]
BLAST of LRP2-binding protein vs. Ensembl Xenopus
Match: ampd3 (adenosine monophosphate deaminase 3 [Source:Xenbase;Acc:XB-GENE-984137])

HSP 1 Score: 56.9954 bits (136), Expect = 3.474e-8
Identity = 64/204 (31.37%), Postives = 93/204 (45.59%), Query Frame = 2 
Query:  203 IILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFG-VKQSVEKALEYWLFAADDGSPVASVYAQTMLG--FFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYA 805
            ++ R R+   ++      G L       ED I Y+ F A K  D+Q    +G L+  G +      +   + +   YF +   A +  +A AF LG+ Y  G   V QS E AL+Y+  AAD G+PV     Q+ LG  + Y     +D   A+ +  +A   G    Q  LG MY+ GIG K D+  AL     AS+ G I A
Sbjct:  350 VVQRIRLADEVENPGMASGML------EEDLIQYYQFLAEK-GDVQAQVGLGQLHLHGGR-----GVEQNHQRAFEYFNQAANAGN-SHAMAF-LGKMYSEGSDTVIQSNETALQYFRKAADMGNPVG----QSGLGMAYLYGRGVPVDYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKKDYKQALKYFNLASQGGHILA 535
[Close]
BLAST of LRP2-binding protein vs. Ensembl Xenopus
Match: ampd3 (adenosine monophosphate deaminase 3 [Source:Xenbase;Acc:XB-GENE-984137])

HSP 1 Score: 56.9954 bits (136), Expect = 3.801e-8
Identity = 64/204 (31.37%), Postives = 93/204 (45.59%), Query Frame = 2 
Query:  203 IILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFG-VKQSVEKALEYWLFAADDGSPVASVYAQTMLG--FFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYA 805
            ++ R R+   ++      G L       ED I Y+ F A K  D+Q    +G L+  G +      +   + +   YF +   A +  +A AF LG+ Y  G   V QS E AL+Y+  AAD G+PV     Q+ LG  + Y     +D   A+ +  +A   G    Q  LG MY+ GIG K D+  AL     AS+ G I A
Sbjct:  356 VVQRIRLADEVENPGMASGML------EEDLIQYYQFLAEK-GDVQAQVGLGQLHLHGGR-----GVEQNHQRAFEYFNQAANAGN-SHAMAF-LGKMYSEGSDTVIQSNETALQYFRKAADMGNPVG----QSGLGMAYLYGRGVPVDYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKKDYKQALKYFNLASQGGHILA 541
[Close]
BLAST of LRP2-binding protein vs. Ensembl Mouse
Match: Lrp2bp (Lrp2 binding protein [Source:MGI Symbol;Acc:MGI:1914870])

HSP 1 Score: 225.328 bits (573), Expect = 3.977e-70
Identity = 129/291 (44.33%), Postives = 176/291 (60.48%), Query Frame = 2 
Query:  209 LRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDNIGD------SSDSMR----KGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEIS 1051
            L++RI++G   A F  GQL F    YE+A+  F     + KD Q +YQ+GV+YYDGL    +AE    YM++IL     P+  HL +AAA+NLGRAY+ G GVK+S E+A   WL AAD+G+P ASV AQ++LG FY  +E  ++ KA FWHSEAC NGS +SQ  LG+MYF G G + D  AAL CLR A+ERG +YAQG L  YYY  K +      + R+  A  D + D       +D +     KG+A+A F + RCL LG G+ K+   ++ Y  K+   N  ++
Sbjct:   49 LKERIRRGDAMAYFLRGQLYFEEGWYEEALAQFE--EIQEKDHQAIYQLGVMYYDGLGTIANAEKGVNYMRKIL-DSSCPQTMHLKFAAAYNLGRAYFEGKGVKRSDEEAERLWLLAADNGNPKASVKAQSILGLFYSMKEPKELEKAFFWHSEACGNGSLESQGALGLMYFYGQGIRQDTDAALHCLREAAERGNVYAQGTLVEYYYKMKFFTKCVSFSKRI--ADYDEVHDIPMIAHVTDCLPEFIIKGMAMAAFYHGRCLQLGLGIMKDEESAKHYYSKACRLNPTLA 334
[Close]
BLAST of LRP2-binding protein vs. Ensembl Mouse
Match: Lrp2bp (Lrp2 binding protein [Source:MGI Symbol;Acc:MGI:1914870])

HSP 1 Score: 225.328 bits (573), Expect = 3.977e-70
Identity = 129/291 (44.33%), Postives = 176/291 (60.48%), Query Frame = 2 
Query:  209 LRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDNIGD------SSDSMR----KGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEIS 1051
            L++RI++G   A F  GQL F    YE+A+  F     + KD Q +YQ+GV+YYDGL    +AE    YM++IL     P+  HL +AAA+NLGRAY+ G GVK+S E+A   WL AAD+G+P ASV AQ++LG FY  +E  ++ KA FWHSEAC NGS +SQ  LG+MYF G G + D  AAL CLR A+ERG +YAQG L  YYY  K +      + R+  A  D + D       +D +     KG+A+A F + RCL LG G+ K+   ++ Y  K+   N  ++
Sbjct:   49 LKERIRRGDAMAYFLRGQLYFEEGWYEEALAQFE--EIQEKDHQAIYQLGVMYYDGLGTIANAEKGVNYMRKIL-DSSCPQTMHLKFAAAYNLGRAYFEGKGVKRSDEEAERLWLLAADNGNPKASVKAQSILGLFYSMKEPKELEKAFFWHSEACGNGSLESQGALGLMYFYGQGIRQDTDAALHCLREAAERGNVYAQGTLVEYYYKMKFFTKCVSFSKRI--ADYDEVHDIPMIAHVTDCLPEFIIKGMAMAAFYHGRCLQLGLGIMKDEESAKHYYSKACRLNPTLA 334
[Close]
BLAST of LRP2-binding protein vs. Ensembl Mouse
Match: Lrp2bp (Lrp2 binding protein [Source:MGI Symbol;Acc:MGI:1914870])

HSP 1 Score: 225.328 bits (573), Expect = 7.325e-70
Identity = 129/291 (44.33%), Postives = 176/291 (60.48%), Query Frame = 2 
Query:  209 LRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDNIGD------SSDSMR----KGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEIS 1051
            L++RI++G   A F  GQL F    YE+A+  F     + KD Q +YQ+GV+YYDGL    +AE    YM++IL     P+  HL +AAA+NLGRAY+ G GVK+S E+A   WL AAD+G+P ASV AQ++LG FY  +E  ++ KA FWHSEAC NGS +SQ  LG+MYF G G + D  AAL CLR A+ERG +YAQG L  YYY  K +      + R+  A  D + D       +D +     KG+A+A F + RCL LG G+ K+   ++ Y  K+   N  ++
Sbjct:   70 LKERIRRGDAMAYFLRGQLYFEEGWYEEALAQFE--EIQEKDHQAIYQLGVMYYDGLGTIANAEKGVNYMRKIL-DSSCPQTMHLKFAAAYNLGRAYFEGKGVKRSDEEAERLWLLAADNGNPKASVKAQSILGLFYSMKEPKELEKAFFWHSEACGNGSLESQGALGLMYFYGQGIRQDTDAALHCLREAAERGNVYAQGTLVEYYYKMKFFTKCVSFSKRI--ADYDEVHDIPMIAHVTDCLPEFIIKGMAMAAFYHGRCLQLGLGIMKDEESAKHYYSKACRLNPTLA 355
[Close]
BLAST of LRP2-binding protein vs. Ensembl Mouse
Match: Lrp2bp (Lrp2 binding protein [Source:MGI Symbol;Acc:MGI:1914870])

HSP 1 Score: 126.331 bits (316), Expect = 9.436e-34
Identity = 69/148 (46.62%), Postives = 95/148 (64.19%), Query Frame = 2 
Query:  209 LRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKA 652
            L++RI++G   A F  GQL F    YE+A+  F     + KD Q +YQ+GV+YYDGL    +AE    YM++IL     P+  HL +AAA+NLGRAY+ G GVK+S E+A   WL AAD+G+P ASV AQ++LG FY  +E  ++ K 
Sbjct:   49 LKERIRRGDAMAYFLRGQLYFEEGWYEEALAQFE--EIQEKDHQAIYQLGVMYYDGLGTIANAEKGVNYMRKIL-DSSCPQTMHLKFAAAYNLGRAYFEGKGVKRSDEEAERLWLLAADNGNPKASVKAQSILGLFYSMKEPKELEKT 193
[Close]
BLAST of LRP2-binding protein vs. Ensembl Mouse
Match: Sel1l (sel-1 suppressor of lin-12-like (C. elegans) [Source:MGI Symbol;Acc:MGI:1329016])

HSP 1 Score: 55.0694 bits (131), Expect = 1.229e-7
Identity = 63/204 (30.88%), Postives = 91/204 (44.61%), Query Frame = 2 
Query:  203 IILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFG-VKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIA--KAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYA 805
            ++ R R+   ++      G L       ED I Y+ F A K  D+Q    +G L+  G +      +   + +   YF     A +  +A AF LG+ Y  G   V QS E AL Y+  AAD G+PV     Q+ LG  Y +   + +    A+ +  +A   G    Q  LG MY+ GIG K D+  AL     AS+ G I A
Sbjct:  282 VVQRIRLPDEVENPGMNSGML------EEDLIQYYQFLAEK-GDVQAQVGLGQLHLHGGR-----GVEQNHQRAFDYFNLAANAGN-SHAMAF-LGKMYSEGSDIVPQSNETALHYFKKAADMGNPVG----QSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILA 467
[Close]
BLAST of LRP2-binding protein vs. UniProt/SwissProt
Match: sp|Q6IND7|LR2BP_XENLA (LRP2-binding protein OS=Xenopus laevis OX=8355 GN=lrp2bp PE=2 SV=1)

HSP 1 Score: 246.899 bits (629), Expect = 1.230e-77
Identity = 133/282 (47.16%), Postives = 185/282 (65.60%), Query Frame = 2 
Query:  200 EIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDNIG---DSSDSMR----KGLALAYFIYARCLNLGFGVQKNACLS-QLYSK 1021
            E  L+ RIK+G  +A F  GQL F    YEDA+    F   K +D Q +YQ GV+YYDGL  Q D      YM++I+   + P A+HL YAAA+NLGRAY+ G+G+  S ++A  +WLFAAD+G+P AS+ AQ++LG +Y    ++D+ KA  WHSEAC NGS +SQ  LGVMY  G G K +  AA+ CL+ A+ERG +YAQG L   YY RKLY  A +LA +++S   DNI    +++D +     KG+A+A F +ARCL+LG G+++++  + QLYSK
Sbjct:   44 ETFLKSRIKEGDVQANFLLGQLFFEEGWYEDAL--LQFEKVKDEDNQALYQAGVMYYDGLGTQEDHRKGVKYMERIV-TSDCPSAKHLKYAAAYNLGRAYFEGYGIPHSDKEAERWWLFAADNGNPKASLKAQSVLGMYYSSPPNVDLQKAFLWHSEACGNGSLESQGALGVMYLYGNGIKKNVQAAIECLKEAAERGNVYAQGHLVSCYYQRKLYTKAVELAKKIVSH--DNIELLVNTTDCLPSYTVKGVAIATFYFARCLHLGLGIKQDSTAAKQLYSK 320
[Close]
BLAST of LRP2-binding protein vs. UniProt/SwissProt
Match: sp|Q569C2|LR2BP_RAT (LRP2-binding protein OS=Rattus norvegicus OX=10116 GN=Lrp2bp PE=2 SV=1)

HSP 1 Score: 236.113 bits (601), Expect = 1.858e-73
Identity = 133/291 (45.70%), Postives = 178/291 (61.17%), Query Frame = 2 
Query:  209 LRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDNIGDS----------SDSMRKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEIS 1051
            L++RI+KG   A F  GQL F    YE+A+    F   + KD Q +YQ+GV+YYDGL    DAE   GYMK+IL     P+  HL +AAA+NLGRAY+ G GVK+S E+A   WL+AAD+G+P ASV AQ++LG FY  +E  D+ KA FWHSEAC NG+ +SQ  LG+MY  G G + D  AAL CLR A+ERG +YAQG+L  YYY  K +      + R+  A  D + D            + + KG+A+A F YARCL LG G+ K+   ++ Y  K+   N  ++
Sbjct:   49 LKERIRKGDAMAYFLRGQLYFEEGWYEEAL--AQFEEIQEKDHQAIYQLGVMYYDGLGTVADAEKGVGYMKKIL-DSSCPQTMHLKFAAAYNLGRAYFEGKGVKRSDEEAERLWLYAADNGNPKASVKAQSILGLFYSMKEPKDLEKAFFWHSEACGNGNLESQGALGLMYLYGQGIRQDTDAALHCLREAAERGNVYAQGILVEYYYKMKFFTKCVSFSKRI--ADYDEVHDIPMIAHVTDCLPEFISKGMAMASFYYARCLQLGLGITKDEASAKHYYSKACRLNPTLA 334
[Close]
BLAST of LRP2-binding protein vs. UniProt/SwissProt
Match: sp|Q9P2M1|LR2BP_HUMAN (LRP2-binding protein OS=Homo sapiens OX=9606 GN=LRP2BP PE=1 SV=2)

HSP 1 Score: 234.187 bits (596), Expect = 1.354e-72
Identity = 142/328 (43.29%), Postives = 189/328 (57.62%), Query Frame = 2 
Query:   74 LPTNIPIEQVSFDAALIKELKVLDIIKPHRKCVHMLKINNNLEIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDNIGDS----------SDSMRKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKS 1027
            LP N     VS  AA  K  K     K      H   ++  L++ L++RI KG   A F  GQL F    YE+A+  F     K KD Q  YQ+GV+YYDGL   +DAE    YMK+IL     P+ARHL +AAA+NLGRAYY G GVK+S E+A   WL AAD+G+P ASV AQ+MLG +Y  +E  ++ KA +WHSEAC NG+ +SQ  LG+MY  G G + D  AAL CLR A+ERG +YAQG L  YYY  K +      + R+  A  D + D            + + +G+A+A F +ARCL LG G+ ++   ++ Y  K+
Sbjct:    8 LPKNPFYASVSQYAA--KNQKFFQWKKEKTDYTHANLVDKALQL-LKERILKGDTLAYFLRGQLYFEEGWYEEALEQFE--EIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKKIL-DSPCPKARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKASVKAQSMLGLYYSTKEPKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYKMKFFTKCVAFSKRI--ADYDEVHDIPMIAQVTDCLPEFIGRGMAMASFYHARCLQLGLGITRDETTAKHYYSKA 327
[Close]
BLAST of LRP2-binding protein vs. UniProt/SwissProt
Match: sp|Q4R3N2|LR2BP_MACFA (LRP2-binding protein OS=Macaca fascicularis OX=9541 GN=LRP2BP PE=2 SV=1)

HSP 1 Score: 230.335 bits (586), Expect = 4.339e-71
Identity = 130/299 (43.48%), Postives = 180/299 (60.20%), Query Frame = 2 
Query:  206 ILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDNIGDS----------SDSMRKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEISLYFKQLV 1072
            +L+ RI KG   A F  GQL F    YE+A+  F     + KD Q  YQ+GV+YYDGL   +++E    YMK+IL     P+ARHL +AAA+NLGRAYY G GVK+S E+A   WLFAAD+G+P ASV AQ+MLG +Y  +E  ++ KA +WHSEAC NG+ +SQ  LG+MY  G G + D  AAL CLR A+ERG +YAQG L  YYY  K +      + R+  A  D + D            + + +G+A+A F +ARCL LG G+ ++   ++ Y  K+   N  ++   + L+
Sbjct:   50 LLKKRILKGDTLAYFLRGQLYFEEGWYEEALEQFE--EIEEKDHQATYQLGVMYYDGLGTILNSEKGVDYMKKIL-DSPCPKARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLFAADNGNPKASVKAQSMLGLYYSTKEPKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALHCLREAAERGNVYAQGNLVEYYYKMKFFTKCVAFSKRI--ADYDEVHDIPMIAQVTDCLPEFISRGMAMASFYHARCLQLGLGITRDEATAKHYYSKACRLNPALADELRSLL 343
[Close]
BLAST of LRP2-binding protein vs. UniProt/SwissProt
Match: sp|Q9D4C6|LR2BP_MOUSE (LRP2-binding protein OS=Mus musculus OX=10090 GN=Lrp2bp PE=2 SV=1)

HSP 1 Score: 225.328 bits (573), Expect = 2.782e-69
Identity = 129/291 (44.33%), Postives = 176/291 (60.48%), Query Frame = 2 
Query:  209 LRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDNIGD------SSDSMR----KGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEIS 1051
            L++RI++G   A F  GQL F    YE+A+  F     + KD Q +YQ+GV+YYDGL    +AE    YM++IL     P+  HL +AAA+NLGRAY+ G GVK+S E+A   WL AAD+G+P ASV AQ++LG FY  +E  ++ KA FWHSEAC NGS +SQ  LG+MYF G G + D  AAL CLR A+ERG +YAQG L  YYY  K +      + R+  A  D + D       +D +     KG+A+A F + RCL LG G+ K+   ++ Y  K+   N  ++
Sbjct:   49 LKERIRRGDAMAYFLRGQLYFEEGWYEEALAQFE--EIQEKDHQAIYQLGVMYYDGLGTIANAEKGVNYMRKIL-DSSCPQTMHLKFAAAYNLGRAYFEGKGVKRSDEEAERLWLLAADNGNPKASVKAQSILGLFYSMKEPKELEKAFFWHSEACGNGSLESQGALGLMYFYGQGIRQDTDAALHCLREAAERGNVYAQGTLVEYYYKMKFFTKCVSFSKRI--ADYDEVHDIPMIAHVTDCLPEFIIKGMAMAAFYHGRCLQLGLGIMKDEESAKHYYSKACRLNPTLA 334
[Close]
BLAST of LRP2-binding protein vs. TrEMBL
Match: A0A267GK49 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig010278g2 PE=4 SV=1)

HSP 1 Score: 284.648 bits (727), Expect = 1.333e-89
Identity = 146/351 (41.60%), Postives = 225/351 (64.10%), Query Frame = 2 
Query:   53 STTLLGSLPTNIPIEQVSFDAALIKELKVLDIIKPHRKCVHMLKINNNLEIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIG-KKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARV-----ISAAPDNIGDSSDSMRKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEISLYFKQLVGIGQM 1087
            S + + SL  ++P +++     +  E+++L+    H++     ++ + LE +LR R+++G  +A FQ GQLLF    Y+++   F    +KF+D Q M+Q+GV++YDGL  + + E    YM ++   K+   ++ L +AAA+N+GRAY+ G+GV+Q+ EKA E+WL AADDG+P ASV AQT LG+FY H +H D+ KA FWHSEAC NGS +SQ  LGVMY  G+G ++ D  +A  CLR A+ERG +YAQG + +YYYS+KL+  AA+LAARV     I+A  +     +  + KG+ALA FI+ARCL  G GVQK+   ++ +   S+ ++ +     + L  +GQ+
Sbjct:   12 SPSGMESLSRDLPGQKLPISRPMSHEVELLE---DHQRLSET-ELVSRLERVLRLRMERGDSQAAFQLGQLLFEQSRYDESRRLFEIAVSKFEDTQAMFQLGVIHYDGLVGEANPERGIRYMMEVCKRKDQLPSKQLYFAAAYNIGRAYFQGYGVRQNDEKAEEWWLAAADDGNPRASVLAQTTLGYFYSHADHRDLQKAFFWHSEACGNGSLESQGALGVMYLYGLGVRRRDSESAFECLREAAERGNVYAQGNMVYYYYSKKLFTKAAELAARVVQYDDIAALAEETQCQARFVSKGVALASFIFARCLQQGLGVQKDLDKAKHFYSLSFQFDPDTCARLQNLQNVGQL 358
[Close]
BLAST of LRP2-binding protein vs. TrEMBL
Match: A0A1I8GWY5 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 283.493 bits (724), Expect = 2.350e-89
Identity = 145/347 (41.79%), Postives = 223/347 (64.27%), Query Frame = 2 
Query:   65 LGSLPTNIPIEQVSFDAALIKELKVLDIIKPHRKCVHMLKINNNLEIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIG-KKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARV-----ISAAPDNIGDSSDSMRKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEISLYFKQLVGIGQM 1087
            + SL  ++P +++     +  E+++L+    H++     ++ + LE +LR R+++G  +A FQ GQLLF    Y+++   F    +KF+D Q M+Q+GV++YDGL  + + E    YM ++   K+   ++ L +AAA+N+GRAY+ G+GV+Q+ EKA E+WL AADDG+P ASV AQT LG+FY H +H D+ KA FWHSEAC NGS +SQ  LGVMY  G+G ++ D  +A  CLR A+ERG +YAQG + +YYYS+KL+  AA+LAARV     I+A  +     +  + KG+ALA FI+ARCL  G GVQK+   ++ +   S+ ++ +     + L  +GQ+
Sbjct:    1 MESLSRDLPGQKLPISRPMSHEVELLE---DHQRLSET-ELVSRLERVLRLRMERGDSQAAFQLGQLLFEQSRYDESRRLFEIAVSKFEDTQAMFQLGVIHYDGLVGEANPERGIRYMMEVCKRKDQLPSKQLYFAAAYNIGRAYFQGYGVRQNDEKAEEWWLAAADDGNPRASVLAQTTLGYFYSHADHRDLQKAFFWHSEACGNGSLESQGALGVMYLYGLGVRRRDSESAFECLREAAERGNVYAQGNMVYYYYSKKLFTKAAELAARVVQYDDIAALAEETQCQARFVSKGVALASFIFARCLQQGLGVQKDLDKAKHFYSLSFQFDPDTCARLQNLQNVGQL 343
[Close]
BLAST of LRP2-binding protein vs. TrEMBL
Match: R7THG8 (TPR_REGION domain-containing protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_223760 PE=4 SV=1)

HSP 1 Score: 249.595 bits (636), Expect = 3.638e-76
Identity = 142/348 (40.80%), Postives = 201/348 (57.76%), Query Frame = 2 
Query:   74 LPTNIPIEQVSFDAALIKE-------LKVLDIIKPHRKCVHMLKINNNLEIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARV-ISAAPDNIGDSSDSM----RKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEISLYFKQLVGIG 1081
            L   I  EQ+ F   L  +        K L + K   + +   ++   LE +L ++I  G ++A FQ GQL F    YE A  +F   A    D Q ++Q+GV+YYDGL    D   A GYM++I+   +  +  HL +AA +N+GRAY  G+G KQS E A ++WL AADDG+P AS+ AQ+ LG FY  E+HLD+ KA +WHSEAC N + +SQ  LGVMY  G+G K D  AA +CLR A+ RG +YA G L  +YY RK Y    +LAARV +    D I   +D +     KG+++A F YARCL+LG GVQKN   ++ Y  +S+ ++ ++    + +   G
Sbjct:    3 LARQISGEQLPFRRRLTTQNESSEHLAKSLHLNKRQVEEMEDDELTEKLETVLLEKIHNGDRQALFQLGQLYFELGKYEKARTFFERAAEN-DDYQAIFQLGVIYYDGLHGHSDCAKALGYMQRIIE-ADPKKVDHLTHAACYNIGRAYLQGYGCKQSDELAEKFWLIAADDGNPNASIKAQSALGLFYSREDHLDLKKAFYWHSEACGNNNLESQGALGVMYQNGLGVKQDASAAFVCLREAASRGNVYAMGNLVSHYYKRKFYTKCMELAARVAMFDDVDQIAKETDCLPCFISKGISMAAFYYARCLHLGLGVQKNEAEAKKYYSRSFEFDSDVCAKLQNITQHG 348
[Close]
BLAST of LRP2-binding protein vs. TrEMBL
Match: A0A1S3I3V1 (LRP2-binding protein OS=Lingula unguis OX=7574 GN=LOC106160433 PE=4 SV=2)

HSP 1 Score: 248.825 bits (634), Expect = 7.176e-76
Identity = 142/345 (41.16%), Postives = 203/345 (58.84%), Query Frame = 2 
Query:   86 IPIEQV--SFDAALIKELKVLD-IIKPHRKCVHMLKINNNLEIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARV--------ISAAPDNIGDSSDSMRKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEISLYFKQLVGIGQM 1087
            IP E +  S D +++  +   D   K +   +   ++   +E +L D+IK G K+A FQ GQL F   +++ A+ YF     K  D Q +YQ+GV+YYDGL  + D ++  G M Q+       +A+HL++ A +N+GRA+Y GFG+ QS E+A  +WL AADDG+P  S+ AQ+MLG FY   E LD+ KA FWHSEAC NGS +SQ  LGVM  LG+G K D  A+  C + A++RG +YA G L  YYY RKLY  AADLAARV        I+A    I      + KG+++A F YARCL+ G GV+ N   +  Y  KS+  + ++    + +   G++
Sbjct:    7 IPGEPLPASRDGSMVYSVSTADGEAKENLSSLTEEELTGKVESMLLDKIKNGDKQAVFQLGQLYFEQGVFDKAVNYFE--RAKEYDFQALYQLGVMYYDGLGCEQDPKIGSGCMLQVA-TSTAKQAQHLVHVAQYNVGRAFYQGFGLTQSDEEAERWWLLAADDGNPNGSILAQSMLGMFYSRPETLDLKKAYFWHSEACGNGSLESQGALGVMLELGLGCKKDTNASFECFKEAADRGNVYAMGHLVKYYYMRKLYTKAADLAARVAMLDDIYQIAAETTCI---PGYIAKGISMACFFYARCLHKGHGVEANEEEAGKYYSKSHDLDPDMCATLQGITTHGKI 345
[Close]
BLAST of LRP2-binding protein vs. TrEMBL
Match: A0A401S999 (Uncharacterized protein OS=Chiloscyllium punctatum OX=137246 GN=chiPu_0005392 PE=4 SV=1)

HSP 1 Score: 248.825 bits (634), Expect = 1.242e-75
Identity = 136/279 (48.75%), Postives = 172/279 (61.65%), Query Frame = 2 
Query:  200 EIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDN---IGDSSDSMR----KGLALAYFIYARCLNLGFGVQKNACLSQLY 1015
            + ILR RI  G  +A F  GQL F    +E A   FN    K  D Q +YQ+GV+YYDGL  + +  L   YM +I+   E P A+HL + A +NLGRA + GFG++QS  +A   WL AADDG+P ASV AQT+LG FY   E  D+ KA FWHSEAC NGS +SQ VLG+MY  G G + D  +A  CL+ AS RG +YAQG L  Y+YSRKLY+N  DLA RV+    DN   I   +D +     KG+A+A F YARCL LG G+Q+N   +  Y
Sbjct:   62 DAILRKRINDGDLQAIFLLGQLYFEEGCFETAFEEFN--KIKDTDFQALYQLGVMYYDGLGTKENPALGVEYMNRIIN-SEDPRAQHLKFVAYYNLGRASFEGFGIQQSNAEAERLWLLAADDGNPKASVKAQTILGLFYSRPESQDLQKAFFWHSEACGNGSLESQGVLGLMYLTGQGIRKDTQSAWNCLKEASSRGNVYAQGHLVAYFYSRKLYYNTVDLAQRVVEY--DNIPRIAKETDCLPVYIAKGIAMAAFYYARCLQLGLGIQQNQTEAMKY 335
[Close]
BLAST of LRP2-binding protein vs. Ensembl Cavefish
Match: lrp2bp (LRP2 binding protein [Source:NCBI gene;Acc:103026521])

HSP 1 Score: 214.542 bits (545), Expect = 5.589e-66
Identity = 124/288 (43.06%), Postives = 168/288 (58.33%), Query Frame = 2 
Query:  200 EIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARV-----ISAAPDNIGDSSDSMRKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEI 1048
            E +L+ R + G  +A F  GQL +    Y +A   F+    K K+   +YQ+ V+YYDGL   ++   A  YM+++  +   P    + Y+A +NLGRAY  G+GV+ S  +A  Y+L AAD G+P ASV AQ+ LG FY   E  D+ KA FWHSEAC NGS +SQ  LG+MY  G G   D  AAL CL+ A+ERG +YAQ  L  +YY +KLY  AA LA R+     ISA   + G   + + KG+A+A F YARCL LG GV  +   +Q Y  K+   N E+
Sbjct:   58 ERLLKSRAETGDTQASFLIGQLYYEEGRYTEAEAIFD--GIKDKEPCALYQLAVMYYDGLGTSVNQVKAVDYMRRVAAWDSSP----IKYSALYNLGRAYLQGYGVQASSSEAERYFLLAADGGNPNASVKAQSYLGLFYSSPETQDLQKAYFWHSEACGNGSLESQGALGIMYLHGYGVPKDLQAALCCLKEAAERGNVYAQSHLAAHYYHQKLYTKAAALAQRICQYEDISAIAKSTGCLPEYISKGIAIALFYYARCLQLGRGVPLDMETAQQYYAKAALMNPEV 339
[Close]
BLAST of LRP2-binding protein vs. Ensembl Cavefish
Match: lrp2bp (LRP2 binding protein [Source:NCBI gene;Acc:103026521])

HSP 1 Score: 211.46 bits (537), Expect = 1.820e-64
Identity = 123/287 (42.86%), Postives = 166/287 (57.84%), Query Frame = 2 
Query:  200 EIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARV-----ISAAPDNIGDSSDSMRKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVE 1045
            E +L+ R + G  +A F  GQL +    Y +A   F+    K K+   +YQ+ V+YYDGL   ++   A  YM+++  +   P    + Y+A +NLGRAY  G+GV+ S  +A  Y+L AAD G+P ASV AQ+ LG FY   E  D+ KA FWHSEAC NGS +SQ  LG+MY  G G   D  AAL CL+ A+ERG +YAQ  L  +YY +KLY  AA LA R+     ISA   + G   + + KG+A+A F YARCL LG GV  +   +Q Y  K +    E
Sbjct:   58 ERLLKSRAETGDTQASFLIGQLYYEEGRYTEAEAIFD--GIKDKEPCALYQLAVMYYDGLGTSVNQVKAVDYMRRVAAWDSSP----IKYSALYNLGRAYLQGYGVQASSSEAERYFLLAADGGNPNASVKAQSYLGLFYSSPETQDLQKAYFWHSEACGNGSLESQGALGIMYLHGYGVPKDLQAALCCLKEAAERGNVYAQSHLAAHYYHQKLYTKAAALAQRICQYEDISAIAKSTGCLPEYISKGIAIALFYYARCLQLGRGVPLDMETAQQYYAKVFIQTAE 338
[Close]
BLAST of LRP2-binding protein vs. Ensembl Cavefish
Match: sel1l (SEL1L adaptor subunit of ERAD E3 ubiquitin ligase [Source:ZFIN;Acc:ZDB-GENE-041001-122])

HSP 1 Score: 51.2174 bits (121), Expect = 1.672e-6
Identity = 54/178 (30.34%), Postives = 84/178 (47.19%), Query Frame = 2 
Query:  281 MYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFG-VKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIA--KAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYA 805
            + ED I Y+ F A K  D+Q    +G L+  G +      +   + +   YF +   A +  +A AF LG+ Y  G   + Q+ + AL Y+  A++ G+PV     Q+ LG  Y +   + +    A+ +  +A   G    Q  LG MY+ GIG K D+  AL     AS+ G I A
Sbjct:  382 LEEDLIQYYQFLAEK-GDVQAQVGLGQLHLHGGR-----GVEQNHQRAYEYFNQAANAGN-THAMAF-LGKMYSEGSEFLPQNNDTALHYFKKASEQGNPVG----QSGLGMAYLYGRGVPVNYDLALKYFQKAAEQGWVDGQLQLGTMYYNGIGVKRDYKQALKFFNLASQAGHILA 547
[Close]
BLAST of LRP2-binding protein vs. Ensembl Cavefish
Match: sel1l (SEL1L adaptor subunit of ERAD E3 ubiquitin ligase [Source:ZFIN;Acc:ZDB-GENE-041001-122])

HSP 1 Score: 50.447 bits (119), Expect = 2.516e-6
Identity = 54/178 (30.34%), Postives = 84/178 (47.19%), Query Frame = 2 
Query:  281 MYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFG-VKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIA--KAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYA 805
            + ED I Y+ F A K  D+Q    +G L+  G +      +   + +   YF +   A +  +A AF LG+ Y  G   + Q+ + AL Y+  A++ G+PV     Q+ LG  Y +   + +    A+ +  +A   G    Q  LG MY+ GIG K D+  AL     AS+ G I A
Sbjct:  380 LEEDLIQYYQFLAEK-GDVQAQVGLGQLHLHGGR-----GVEQNHQRAYEYFNQAANAGN-THAMAF-LGKMYSEGSEFLPQNNDTALHYFKKASEQGNPVG----QSGLGMAYLYGRGVPVNYDLALKYFQKAAEQGWVDGQLQLGTMYYNGIGVKRDYKQALKFFNLASQAGHILA 545
[Close]
BLAST of LRP2-binding protein vs. Ensembl Sea Lamprey
Match: lrp2bp (LRP2 binding protein [Source:NCBI gene;Acc:100073340])

HSP 1 Score: 216.853 bits (551), Expect = 3.563e-68
Identity = 123/295 (41.69%), Postives = 174/295 (58.98%), Query Frame = 2 
Query:  218 RIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAP-DNIGDSSDSM----RKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEISLYFKQLVGIGQM 1087
            R+  G ++A F  GQL F    +  A  +F        D + +YQ+GV+YYD L +  D E     M  +    E   AR + YAA FN+G+A++ GFG KQS  +A  +WL AADDG+P+ASV AQ+MLG FY   E L + KA FWHSEAC NGS +SQ  LG+MY LG+G + D  +AL CL  A++RG +YAQ  L    ++R+LY  AA+LAARV  A     +   +D +     KG+A+A F Y RCL LG GV ++   ++ Y  K++  + +I+  F+  V  G++
Sbjct:   14 RVSAGDQDARFLLGQLYFHKGCFASARLHFEV--VSHTDARALYQLGVMYYDTLGMPADLEKGVDCMLGVTKM-EGGRARLVKYAAMFNIGQAHFSGFGAKQSDTEAERWWLLAADDGNPLASVKAQSMLGMFYSRPESLHLKKAFFWHSEACGNGSVESQGALGLMYKLGLGVRRDADSALECLDEAAQRGNLYAQAQLMALLHARRLYVRAAELAARVADAMDVARVARETDCLPTYISKGIAMAAFYYGRCLELGQGVARDPVRARHYYSKAFQCDPDITEEFQLKVTHGEL 305
[Close]
BLAST of LRP2-binding protein vs. Ensembl Nematostella
Match: EDO42764 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0M8])

HSP 1 Score: 211.075 bits (536), Expect = 4.800e-65
Identity = 116/295 (39.32%), Postives = 177/295 (60.00%), Query Frame = 2 
Query:  185 INNNLEIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDNIGDSSDS------MRKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEIS 1051
            +++ LE  L  R K G + A FQ GQ  F   ++E AI  F     K  D Q  YQ+GV+YYDGL  Q   +     +K+I      P+A HL+  A +N+GRAYY G+GVKQS ++A  ++L AA DG P  S+ +QT+LG FY    + +++KA FWH EA  NGS +SQ  LGVM+  GIG  ++  +A  CL+ A+ RG +YAQG L  +YY RKL+  AAD+ A+ ++   D +  + ++      + KG++L  F+YARCL+ GFGV K+   + ++  ++  ++++ +
Sbjct:   44 LDSELEETLIKRAKDGDRLAKFQLGQFYFERGIFEKAIVAFE--RIKSTDFQAKYQLGVMYYDGLGTQAKPDKGVELLKEIA-MSAHPDASHLVPHAQYNIGRAYYEGYGVKQSDKEAERWFLMAARDGDPSGSLRSQTVLGMFYSRPGNENLSKAYFWHQEATGNGSIESQGALGVMFEYGIGVPMNIQSAFECLKGAAIRGNVYAQGNLAVHYYKRKLFNKAADV-AKSVADLDDVMAIARETECLPKYVAKGISLGSFVYARCLHHGFGVDKDEKNALMFYSRAAQFDMDTA 334
[Close]
BLAST of LRP2-binding protein vs. Ensembl Nematostella
Match: EDO40221 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S7M3])

HSP 1 Score: 54.299 bits (129), Expect = 4.960e-8
Identity = 56/177 (31.64%), Postives = 86/177 (48.59%), Query Frame = 2 
Query:  287 EDAIYYFNFGATKFKDLQCMYQIGVLYYDGLK-VQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGV-KQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLD--IAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYA 805
            ED I Y+ F A K  D+Q    +G LY+ G + V++D + A        YF++  EA +   A AF LG+ Y  G  V KQ  + A +++  AAD G+P+     Q+ LG  Y   + +D    KA  +   A   G       +G MY+ G+G + D+  A+     AS+ G + A
Sbjct:  134 EDLIQYYQFLADK-GDVQAQVGLGQLYFQGGRGVELDHQRAN------RYFQQAAEAGN-SNAMAF-LGKMYSEGSEVVKQDNKTAFKWFKKAADMGNPIG----QSGLGLMYMFGKGVDKNYEKAFQYFKMAAEQGWVDGHLQIGTMYYHGLGVRRDYKMAIKFFNLASQSGHVLA 297
[Close]
BLAST of LRP2-binding protein vs. Ensembl Nematostella
Match: EDO44124 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RWH8])

HSP 1 Score: 51.9878 bits (123), Expect = 2.478e-7
Identity = 60/213 (28.17%), Postives = 96/213 (45.07%), Query Frame = 2 
Query:  230 GIKEACFQYGQLLFLNK-MYEDAIYYFNFGATKFKDLQ------CMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHL----DIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYS 835
            G  +A + Y +LL L + +  D I         FK+L         + +G L+Y G+ V  + ++A       L   EL  A++ I  A   LG  Y  G GV+++ EKA + +   AD G   A      ++   YC+   +    D  K+  +H +A   G A +Q  +GV YF G G ++D   A    + A+++G   AQ  L   YY+
Sbjct:  204 GNTDAKYTYAKLLQLGEGVSPDPIE----AGKMFKELAEKGHPFAQFSLGQLHYAGVGVDQNFKIA-------LELFEL-SAKNGILPAYSQLGNMYRTGQGVEENPEKAYQIFKEGADKGDISA------LMAVAYCYSHGVGVQEDSCKSFEFHKKAADQGYASAQYNVGVHYFAGRGVQLDMKLAAEYFQLAAQQGFELAQINLGNMYYN 398
[Close]
BLAST of LRP2-binding protein vs. Ensembl Medaka
Match: sel1l (SEL1L adaptor subunit of ERAD E3 ubiquitin ligase [Source:NCBI gene;Acc:101170143])

HSP 1 Score: 54.6842 bits (130), Expect = 1.312e-7
Identity = 56/178 (31.46%), Postives = 85/178 (47.75%), Query Frame = 2 
Query:  281 MYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFG-VKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDI--AKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYA 805
            + ED I Y+ F A K  D+Q    +G L+  G +      +   + +   YF +   A +  +A AF LG+ Y  G   + Q+ E AL+Y+  A+D G+PV     Q+ LG  Y +   + +    A+ +  +A   G    Q  LG MY+ GIG K D+  AL     AS+ G I A
Sbjct:  337 LEEDLIQYYQFLAEK-GDVQAQVGLGQLHLHGGR-----GVEQNHQRAFDYFTQAANAGN-THAMAF-LGKMYSEGSAFLPQNNETALQYFKKASDLGNPVG----QSGLGMAYLYGRGVPVNYELALKYFQKAAEQGWVDGQLQLGTMYYNGIGVKRDYKQALKFFNLASQAGHILA 502
[Close]
BLAST of LRP2-binding protein vs. Planmine SMEST
Match: SMESG000066814.1 (SMESG000066814.1)

HSP 1 Score: 710.679 bits (1833), Expect = 0.000e+0
Identity = 346/348 (99.43%), Postives = 347/348 (99.71%), Query Frame = 2 
Query:   44 MIKSTTLLGSLPTNIPIEQVSFDAALIKELKVLDIIKPHRKCVHMLKINNNLEIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDNIGDSSDSMRKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEISLYFKQLVGIGQM 1087
            MIKSTTLLGSLPTNIPIEQVSFDAALIKELKVLDIIKPHRKCVHMLKINNNLEIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFN GATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPD+IGDSSDSMRKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEISLYFKQLVGIGQM
Sbjct:    1 MIKSTTLLGSLPTNIPIEQVSFDAALIKELKVLDIIKPHRKCVHMLKINNNLEIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNLGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDSIGDSSDSMRKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEISLYFKQLVGIGQM 348
[Close]
BLAST of LRP2-binding protein vs. Planmine SMEST
Match: SMESG000050759.1 (SMESG000050759.1)

HSP 1 Score: 317.39 bits (812), Expect = 3.673e-106
Identity = 167/338 (49.41%), Postives = 220/338 (65.09%), Query Frame = 2 
Query:   83 NIPIEQVSFDAALIKELKVLDIIKPHRKCVHMLKINNNLEIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQCMYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDNIGDSS--------DSMRKGLALAYFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEISLYFKQLV 1072
            N+ +E+  F   +I EL    II    K    L +N+ LE  L D +  G  EA FQ GQL F  + Y ++I+YF  G  K  D QCM+Q+GV+YYDGL V  D  L C YMK+I   +  P   HL+ +AA+NLGRA Y G+G+KQS  +A +YWLFAADDG+P  SV AQT LGFFY  +EHLD+ KA FWHSEAC NGS +SQA LGV+Y  GIG  V++GAAL+CL +A+ERG IYA+G LC+Y+Y RKL+  AADL+++V     D I   S        + +RKG+++A FI+ARCL+LG GVQ +   +  Y  KSY W+ E+   F++LV
Sbjct:   12 NVKVEKCEFKFNIIDELVEKGIIDTKDKSKPNL-LNSKLEAYLIDHLYSGNNEAFFQLGQLFFDKEDYHESIFYFKGGVDKIGDFQCMFQLGVIYYDGLGVVADPALGCAYMKRIFESQGNPLVSHLLNSAAYNLGRASYQGYGIKQSDSEAEKYWLFAADDGNPQGSVMAQTALGFFYSTKEHLDLKKAFFWHSEACGNGSIESQACLGVLYLYGIGVDVNWGAALICLDNAAERGSIYAKGNLCYYFYKRKLFTKAADLSSKVAQVTEDEIIRLSKHSSIIIEEYLRKGISIACFIFARCLHLGLGVQMDCEEAFKYYSKSYQWDTELCSDFQKLV 348
[Close]
BLAST of LRP2-binding protein vs. Planmine SMEST
Match: SMESG000017711.1 (SMESG000017711.1)

HSP 1 Score: 58.9214 bits (141), Expect = 4.352e-9
Identity = 58/177 (32.77%), Postives = 81/177 (45.76%), Query Frame = 2 
Query:  287 EDAIYYFNFGATKFKDLQCMYQIGVLYYDGLK-VQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGRAYYMGF-GVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHL--DIAKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERGVIYA 805
            +D + Y+ F A K  D+     +G LYY G + V ID E A  Y KQ     EL  +  + Y     LG+ Y  G   V    + ALEY+  A + G+    V   + +G  Y H + +  D  KA  + S A   G    Q  LG+MYF G+G + D   AL     AS+ G + A
Sbjct:  247 DDLLQYYQFLAEK-GDVNAQVGLGQLYYQGGRGVNIDHEKALYYFKQA---SELGNSNAMAY-----LGQIYLEGSEAVPADNQTALEYFKKATEAGN----VIGMSGMGTIYLHGKGVSRDYQKAFKYFSMAADQGWVDGQLQLGIMYFKGLGVRRDHKTALKYFNLASQHGNVLA 410
The following BLAST results are available for this feature:
BLAST of LRP2-binding protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
LRP2BP2.819e-7343.29LRP2 binding protein [Source:HGNC Symbol;Acc:HGNC:... [more]
LRP2BP2.819e-7343.29LRP2 binding protein [Source:HGNC Symbol;Acc:HGNC:... [more]
LRP2BP6.676e-7345.12LRP2 binding protein [Source:HGNC Symbol;Acc:HGNC:... [more]
LRP2BP5.467e-2444.74LRP2 binding protein [Source:HGNC Symbol;Acc:HGNC:... [more]
SEL1L2.405e-730.88SEL1L adaptor subunit of ERAD E3 ubiquitin ligase ... [more]
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BLAST of LRP2-binding protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of LRP2-binding protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of LRP2-binding protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
lrp2bp5.630e-6845.90LRP2 binding protein [Source:NCBI gene;Acc:1000733... [more]
sel1l1.025e-732.58SEL1L adaptor subunit of ERAD E3 ubiquitin ligase ... [more]
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BLAST of LRP2-binding protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lrp2bp4.532e-7747.16LRP2 binding protein [Source:NCBI gene;Acc:1001450... [more]
lrp2bp5.513e-7745.51LRP2 binding protein [Source:NCBI gene;Acc:1001450... [more]
ampd32.710e-831.37adenosine monophosphate deaminase 3 [Source:Xenbas... [more]
ampd33.474e-831.37adenosine monophosphate deaminase 3 [Source:Xenbas... [more]
ampd33.801e-831.37adenosine monophosphate deaminase 3 [Source:Xenbas... [more]
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BLAST of LRP2-binding protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Lrp2bp3.977e-7044.33Lrp2 binding protein [Source:MGI Symbol;Acc:MGI:19... [more]
Lrp2bp3.977e-7044.33Lrp2 binding protein [Source:MGI Symbol;Acc:MGI:19... [more]
Lrp2bp7.325e-7044.33Lrp2 binding protein [Source:MGI Symbol;Acc:MGI:19... [more]
Lrp2bp9.436e-3446.62Lrp2 binding protein [Source:MGI Symbol;Acc:MGI:19... [more]
Sel1l1.229e-730.88sel-1 suppressor of lin-12-like (C. elegans) [Sour... [more]
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BLAST of LRP2-binding protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q6IND7|LR2BP_XENLA1.230e-7747.16LRP2-binding protein OS=Xenopus laevis OX=8355 GN=... [more]
sp|Q569C2|LR2BP_RAT1.858e-7345.70LRP2-binding protein OS=Rattus norvegicus OX=10116... [more]
sp|Q9P2M1|LR2BP_HUMAN1.354e-7243.29LRP2-binding protein OS=Homo sapiens OX=9606 GN=LR... [more]
sp|Q4R3N2|LR2BP_MACFA4.339e-7143.48LRP2-binding protein OS=Macaca fascicularis OX=954... [more]
sp|Q9D4C6|LR2BP_MOUSE2.782e-6944.33LRP2-binding protein OS=Mus musculus OX=10090 GN=L... [more]
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BLAST of LRP2-binding protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A267GK491.333e-8941.60Uncharacterized protein (Fragment) OS=Macrostomum ... [more]
A0A1I8GWY52.350e-8941.79Uncharacterized protein OS=Macrostomum lignano OX=... [more]
R7THG83.638e-7640.80TPR_REGION domain-containing protein OS=Capitella ... [more]
A0A1S3I3V17.176e-7641.16LRP2-binding protein OS=Lingula unguis OX=7574 GN=... [more]
A0A401S9991.242e-7548.75Uncharacterized protein OS=Chiloscyllium punctatum... [more]
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BLAST of LRP2-binding protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
lrp2bp5.589e-6643.06LRP2 binding protein [Source:NCBI gene;Acc:1030265... [more]
lrp2bp1.820e-6442.86LRP2 binding protein [Source:NCBI gene;Acc:1030265... [more]
sel1l1.672e-630.34SEL1L adaptor subunit of ERAD E3 ubiquitin ligase ... [more]
sel1l2.516e-630.34SEL1L adaptor subunit of ERAD E3 ubiquitin ligase ... [more]
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BLAST of LRP2-binding protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
lrp2bp3.563e-6841.69LRP2 binding protein [Source:NCBI gene;Acc:1000733... [more]
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BLAST of LRP2-binding protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of LRP2-binding protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO427644.800e-6539.32Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO402214.960e-831.64Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO441242.478e-728.17Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of LRP2-binding protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
sel1l1.312e-731.46SEL1L adaptor subunit of ERAD E3 ubiquitin ligase ... [more]
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BLAST of LRP2-binding protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000066814.10.000e+099.43SMESG000066814.1[more]
SMESG000050759.13.673e-10649.41SMESG000050759.1[more]
SMESG000017711.14.352e-932.77SMESG000017711.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30025729 ID=SMED30025729|Name=LRP2-binding protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1213bp
TAATATATTAAAAAAATTATTTAACTGGATTATTTAATAATTAATGATTA
AAAGCACAACTTTGTTAGGTTCTTTACCAACAAATATTCCAATCGAGCAA
GTGTCATTTGATGCCGCTCTTATTAAAGAACTTAAAGTGTTGGATATAAT
TAAACCTCACAGGAAATGTGTTCACATGCTAAAAATTAATAATAATTTAG
AAATTATTCTTCGAGATCGTATTAAAAAAGGCATAAAAGAGGCTTGCTTC
CAATATGGGCAGCTTTTATTTTTAAATAAAATGTATGAAGACGCTATTTA
TTACTTTAATTTCGGTGCCACTAAATTCAAAGATTTACAATGCATGTATC
AAATAGGCGTATTATATTATGATGGATTGAAGGTGCAAATTGATGCTGAA
CTTGCTTGTGGATATATGAAACAAATTCTTTATTTTAAAGAGTTACCTGA
AGCCAGACATCTTATTTACGCAGCGGCATTCAATTTGGGAAGGGCCTATT
ACATGGGGTTTGGAGTAAAACAATCTGTGGAAAAGGCATTAGAATATTGG
CTCTTTGCTGCTGACGACGGAAGCCCTGTTGCAAGTGTTTATGCTCAAAC
AATGCTTGGATTCTTTTATTGTCATGAAGAGCATCTTGATATAGCGAAAG
CTATATTTTGGCATTCTGAAGCTTGTAGTAATGGTAGCGCTCAATCACAA
GCTGTTCTTGGTGTTATGTATTTTCTCGGGATAGGGAAAAAAGTTGACTT
TGGCGCCGCATTATTATGCCTGCGACATGCATCAGAAAGAGGAGTAATTT
ATGCTCAAGGAATGTTGTGCTTCTATTATTATTCCAGAAAATTATACTTT
AATGCTGCCGATTTAGCGGCCAGGGTAATTTCGGCAGCTCCAGACAATAT
TGGCGACTCGTCGGATTCTATGCGCAAAGGACTAGCTCTCGCGTACTTCA
TCTATGCAAGATGTTTAAATCTTGGCTTCGGAGTTCAAAAGAATGCGTGC
CTGTCTCAATTATACAGTAAAAAGTCATATGCCTGGAACGTAGAAATTTC
TCTTTATTTTAAGCAATTAGTTGGGATCGGTCAAATGTGACATTATTTCA
TTTGTTATTTTTGTCCCCTAATGAGACATGAAAATTTCCATGAAAGTAAT
CAAATTATTAAAACTTTTTTCAGATAATTTTCAATGTGCCATTATTGATT
GGAATTTATCAAA
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protein sequence of SMED30025729-orf-1

>SMED30025729-orf-1 ID=SMED30025729-orf-1|Name=SMED30025729-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=349bp
MIKSTTLLGSLPTNIPIEQVSFDAALIKELKVLDIIKPHRKCVHMLKINN
NLEIILRDRIKKGIKEACFQYGQLLFLNKMYEDAIYYFNFGATKFKDLQC
MYQIGVLYYDGLKVQIDAELACGYMKQILYFKELPEARHLIYAAAFNLGR
AYYMGFGVKQSVEKALEYWLFAADDGSPVASVYAQTMLGFFYCHEEHLDI
AKAIFWHSEACSNGSAQSQAVLGVMYFLGIGKKVDFGAALLCLRHASERG
VIYAQGMLCFYYYSRKLYFNAADLAARVISAAPDNIGDSSDSMRKGLALA
YFIYARCLNLGFGVQKNACLSQLYSKKSYAWNVEISLYFKQLVGIGQM*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR006597Sel1-like
IPR011990TPR-like_helical_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR006597Sel1-like repeatSMARTSM00671sel1coord: 182..215
e-value: 0.88
score: 18.6
coord: 142..177
e-value: 3.2E-5
score: 33.4
coord: 216..251
e-value: 0.0062
score: 25.8
coord: 298..333
e-value: 110.0
score: 4.6
coord: 98..133
e-value: 64.0
score: 6.6
IPR006597Sel1-like repeatPFAMPF08238Sel1coord: 183..215
e-value: 0.23
score: 12.2
coord: 100..125
e-value: 25.0
score: 5.8
coord: 217..250
e-value: 7.8
score: 7.3
coord: 143..177
e-value: 2.9E-5
score: 24.6
IPR011990Tetratricopeptide-like helical domain superfamilyGENE3DG3DSA:1.25.40.10coord: 55..338
e-value: 1.9E-34
score: 120.9
NoneNo IPR availablePANTHERPTHR44554FAMILY NOT NAMEDcoord: 38..343
NoneNo IPR availableSUPERFAMILYSSF81901HCP-likecoord: 56..275