slc22a-2
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppSub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30025639 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 9
Homology
BLAST of slc22a-2 vs. Ensembl Human
Match: SLC22A5 (solute carrier family 22 member 5 [Source:HGNC Symbol;Acc:HGNC:10969]) HSP 1 Score: 146.362 bits (368), Expect = 8.730e-37 Identity = 153/577 (26.52%), Postives = 253/577 (43.85%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLT--FALYEPKFSCLV---KNISSTIRNST-NLISKD------QCQ-YRLSVNDSWNKC-------------------DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCK-SVYVSLAYTTLIEIIPVS-HIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTL-----NKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGW-AFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMI-----HSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSL--LIHKEQEWKMDMIQQAEKLGMVHRPSKQLDTEF 1768
DY+ + A +G G F + F LS + F GL+ F + P+ C V N+SS RN T L +D C+ YRL+ +++ D W F + +T++ E NLVC+ + L + FFVG L SF LSD G++ +L V++ + T + Q+ S +VL + G+ + S YV+ A+ EI+ S I + Y+FGYM + LFAY R WR + + + + V +WF+PE+PRWL+ R EA + AK N + + E +Q + +LL+ I I++ W S Y G + D +IF+ F+ +VE+P L+ ++ L R+ S++ LG L+ M + D +L L M K G ++A+ + + T EL PT RN + + LGSI +P + L + G + + +L + F+PE+ P+P TI+Q + + + H++ M++ ++ RP+ T F
Sbjct: 3 DYDEVTAFLGEWGPFQRLIFFLLSASIIPN--GFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVA-AFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWN-IRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLY------YLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTL-------FLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQE-----RPTILKSTAF 557
BLAST of slc22a-2 vs. Ensembl Human
Match: SLC22A13 (solute carrier family 22 member 13 [Source:HGNC Symbol;Acc:HGNC:8494]) HSP 1 Score: 142.895 bits (359), Expect = 1.134e-35 Identity = 127/453 (28.04%), Postives = 210/453 (46.36%), Query Frame = 2
Query: 419 NKCDQ-WTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQ--MVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVS----HIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQ-VTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRK-KSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPS 1747
CD W + + + +L NE NLVCDR ++ + F G L + F L D IG++ ++ + L T+I + + S++++ L + + V + ++ T L E + S + LA NF S G M +A AY FR+WR + I + YFW +PE+ RWL+ R +EA + + A +N+ L+ E N+ P + +G +L +H + LI+ + S Y G + + ++++T + G VE+P S M + GRK + L G++C+II+ FI AD P + LA+ K+ ++A+ I + + EL PT R T M LV I +G I P++ +LL Y A +L L I L+ +PETH + T+ Q + L H + ++ E G P
Sbjct: 107 QPCDMGWEYPENRL-PSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNV--TLLTEWVGPSWRTQAVVLAQCNF----SLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIII-FIPAD------LPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLV--ILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTL-QDLELGPHPRSPKSVPSEKETEAKGRTSSPG 542
BLAST of slc22a-2 vs. Ensembl Human
Match: SLC22A5 (solute carrier family 22 member 5 [Source:HGNC Symbol;Acc:HGNC:10969]) HSP 1 Score: 132.88 bits (333), Expect = 4.160e-32 Identity = 154/601 (25.62%), Postives = 254/601 (42.26%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLT--FALYEPKFSCLVK---NISSTIRNST-NLISKD------QCQ-YRLSVNDSWN------------------KC-DQWTFEKRFMRNTLINEL------------------------NLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCK-SVYVSLAYTTLIEIIPVS-HIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTL-----NKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGW-AFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMI-----HSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSL--LIHKEQEWKMDMIQQAEKLGMVHRPSKQLDTEF 1768
DY+ + A +G G F + F LS + F GL+ F + P+ C V N+SS RN T L +D C+ YRL+ +++ C D W F + +T++ E NLVC+ + L + FFVG L SF LSD G++ +L V++ + T + Q+ S +VL + G+ + S YV+ A+ EI+ S I + Y+FGYM + LFAY R WR + + + + V +WF+PE+PRWL+ R EA + AK N + + E +Q + +LL+ I I++ W S Y G + D +IF+ F+ +VE+P L+ ++ L R+ S++ LG L+ M + D +L L M K G ++A+ + + T EL PT RN + + LGSI +P + L + G + + +L + F+PE+ P+P TI+Q + + + H++ M++ ++ RP+ T F
Sbjct: 3 DYDEVTAFLGEWGPFQRLIFFLLSASIIPN--GFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVA-AFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWN-IRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLY------YLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTL-------FLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQE-----RPTILKSTAF 581
BLAST of slc22a-2 vs. Ensembl Human
Match: SLC22A4 (solute carrier family 22 member 4 [Source:HGNC Symbol;Acc:HGNC:10968]) HSP 1 Score: 130.954 bits (328), Expect = 1.523e-31 Identity = 136/556 (24.46%), Postives = 240/556 (43.17%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLV---KNISSTIRN-STNLISKD------QC-QYRLSVNDSWNKC-------------------DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFV-SGVCKSVYVSLAYTTLIEIIPVS-HIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFN---KWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAF-SFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMI-----HSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEK 1723
DY+ + A +G G F + F LS + + F P+ C V N+SS RN S L +D C +YRL+ +++ D W F + +T++ E NLVC+ + L + FFVG L SF LSD G++ +L ++ + T + Q+ S W+ + FV G+ + +A+ EI+ S I + ++ GYM + LFAY R WR + + + + V +WF+PE+PRWL+ +R EA + AK+N + F+ + P++Q +L + + I I++ W S Y + D + ++ F+ L+E+P + ++ L R+ ++A+ G L+ + + D +L + L M K G +SA+ + + T EL PT RN A+ + +GSI AP ++ +L + G + +L + F PE+ + +P+T+EQ + + + D ++ E
Sbjct: 3 DYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSIS-WEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRN-IAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYY------FLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTL-------FFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMETEEN 543
BLAST of slc22a-2 vs. Ensembl Human
Match: SLC22A2 (solute carrier family 22 member 2 [Source:HGNC Symbol;Acc:HGNC:10966]) HSP 1 Score: 124.79 bits (312), Expect = 1.851e-29 Identity = 112/467 (23.98%), Postives = 215/467 (46.04%), Query Frame = 2
Query: 341 SSTIRNSTNLISKDQCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTT----FFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGK-----FWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGL-GIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQ 1711
ST L S D + RL + D W +E ++++ E NLVC ++ +L ++ FF+G S ++D G++L L+ ++ ++ + +S L+ + G+ + Y + E + + + Y+ G + +A AY WR + + + F++LY+W +PE+PRWL+ + EA + + IAK N +L + + +++ TGK F +L++ + +IL + + S Y G + A +NI++ F LVE P + + +++GR+ +A + + G CL + FI D WLK+ ++ ++G + A+ I ++ EL PT RN + + +G I P + L + P +++ +L L+ LV +PET +P+TIE+A ++ ++ + KM +Q
Sbjct: 98 QSTFDCVDPLASLDTNRSRLPLGPCR---DGWVYETP--GSSIVTEFNLVCANSWMLDLFQSSVNVGFFIG---SMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSL-PASLQRLR-LEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASV-FIPGD------LQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLV-LLLPETKGKALPETIEEAENMQRPRKNKEKMIYLQ 546
BLAST of slc22a-2 vs. Ensembl Celegans
Match: oct-2 (Organic Cation Transporter [Source:UniProtKB/TrEMBL;Acc:Q23501]) HSP 1 Score: 124.79 bits (312), Expect = 1.480e-29 Identity = 121/567 (21.34%), Postives = 242/567 (42.68%), Query Frame = 2
Query: 170 FTGMDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLV--------------------KNISSTI------RNSTNLISKDQCQY-----------------RLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFS-FPFSILSDSIGKRLLL----IVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKE-------EFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASE--------NIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSAL---SGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLL 1672
T +D+E + IGGC + I ++ +S+ + + + + +Y+P C + + ++STI N + DQC Y ++ N+C +W ++ M T++ E N VCD + R + ++ +G L F +SD G++ + I+++ ++T + ++I+ LV+ F+ AY +E+ + + + ++ GY +AL AY+ +SW I+++ ++ I ++ +F+PE+PRWL+LN + +A K + NK L + E KW + +++L + + +R ++L A + Y G L+ S N F+ + G +ELPT + ++GRK+S + SGL ++ ++M + + +L ++ K C+ ++ I I T+EL PT RN+A+ + + +G+ + I ++L + + + +PET LP+P TI +V ++
Sbjct: 151 LTDIDFEGILQLIGGCSYWQIIVYLIISVQQVPHAMFNLSVVYMMYQPDHWCKIPFFNEESFSAELGYTNYTWDQVLNSTIAFPRTFNKQRNELHHDQCHYFERDYVHIKLSPWAQVKDMNATGKINRCKEWEYDTSVMDRTIVTEWNRVCDNNWSRAHVHMSYSLGYLVGCFVGGFISDRYGRKTAITGFGILTMLFGFLLTYSK--EFEIF--LVVRFLLAATNEAADLAAYVLCMEVTGTKYRSIVGSLIQAPWACGYAFLALIAYLTKSWTMIHLICVLLHIISLMLLYFLPESPRWLILNNKTKQAEKIIREACHYNKSRLPSDLGLVRHAEKKKWMKHNE-KPSYFHLFRSSELRFRNVVLFIVWIATALVYYGMVIALSDQSSPGRRVFDGNFFLNNAMAGAIELPTLVFC-VFLLRMGRKRSQMLVLFGSGLFLLTSVVMVYRKQSTLALIFMLLSKACI--------QGSFNILYIFTSELNPTVVRNSAVGISSMVARMGAGASGYI-AILSDVTMPLVPMTIFACFSLLAGCLVLLLPETQGLPLPDTILDSVQMV 702
BLAST of slc22a-2 vs. Ensembl Celegans
Match: K05F1.6 (pep chromosome:WBcel235:II:5782942:5787658:1 gene:WBGene00019408.1 transcript:K05F1.6a.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:K05F1.6) HSP 1 Score: 120.553 bits (301), Expect = 4.487e-28 Identity = 152/664 (22.89%), Postives = 273/664 (41.11%), Query Frame = 2
Query: 167 PFTGMDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLV------------------------KNISSTI--RNSTNLISKDQC--------QYR--------LSVNDSWN------KCDQWTFEKRFMRNTLINELNLVCDRAF---YRELIFT-TFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQ--LVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAK-----INKCTLNK----------EEFNKWKPIQQVTGK--FWNLLKHKTMIYRFLILNFAGWAFSFAYIG---SATDLTFASENIFITTF-----VMGLVELPTGPLSGIMANKLGRKKSVS---ALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGS-----------IFAPMIHSVLLQFY--FAGPFXXXXXXXXXXXXXXFAFI-PETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPSKQLDTEFDKFLL*LGLFACI*MTSFRIDETEYECTNHLGQL 1870
P +D+E + IGGC + ++ +++ + + + + +Y+P+F C+V KNIS NS +D C +YR +++++W KC + FEK M T++ + NLVCD F + + ++ + +GC+ I SD IG++ +I LS+++ G + + + L++ +S +C AYT +EI + + + ++ GY +AL AY+ +SW+ I +++ +++ +PE+PRWLM+ R +EA + + + N CT +K + K ++ GK F +L K + YR + + A + Y G + +D + +F F + G +E+PT + + +LGRKK++ SGL II ++ S+ S L + K+ A+ I I T+EL PT RNTA+ + + GS I P++ ++ + FAG + F+ PET P+P+T++ A++ L P+KQ++ +F G+F MT I TE TN + L
Sbjct: 194 PTDPIDFEGILNIIGGCRWWQIWIYVLIALQQIPHAMFNLNVVYMMYDPEFQCMVPGFNDTNDTTISSHGPYLWGVDDIKNISFVFPNANSDGAYQRDSCYFYERSEERYRQLRRMPLETAMSEAWKDVAPKKKCQAYHFEKDVMVETIVTDFNLVCDSWFAKGHAHMFYSIGYLLGCVLG---GIASDKIGRKPTIIGFGILSSML--GVFLPFNDYYPMFLLIRLLSAICNEAADLAAYTLCMEITGTKYRAMVGSMLQAPWALGYALLALIAYLTKSWKTIQVIAAGLHFMSIIFICSIPESPRWLMVQNRVSEAEEVIRKACREPPFPFNMCTTSKCGNLPSDLELVSHRERKLNKKNGGKIGFLDLFTMKELRYRTISVCIVFMATALVYYGLVMALSDQSAPGRTLFTGYFHLNNGIAGAIEIPTL-FACVWMMQLGRKKALMLTLITSGLFIIVAML-------SMVS-GHYMLALAFMYFGKIAVQGAFNILYIFTSELYPTVVRNTAVGVTSMVARFGSGLSSYIALLSNISLPIVPMIIFAVFSLFAG---------------MLVFVLPETSEKPLPETLDDAINFL----------------------EPTKQVNCMMGRF----GVFGHQKMTK-SISLTENPSTNDIADL 801
BLAST of slc22a-2 vs. Ensembl Celegans
Match: K05F1.6 (pep chromosome:WBcel235:II:5782524:5787658:1 gene:WBGene00019408.1 transcript:K05F1.6a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:K05F1.6) HSP 1 Score: 120.553 bits (301), Expect = 4.487e-28 Identity = 152/664 (22.89%), Postives = 273/664 (41.11%), Query Frame = 2
Query: 167 PFTGMDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLV------------------------KNISSTI--RNSTNLISKDQC--------QYR--------LSVNDSWN------KCDQWTFEKRFMRNTLINELNLVCDRAF---YRELIFT-TFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQ--LVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAK-----INKCTLNK----------EEFNKWKPIQQVTGK--FWNLLKHKTMIYRFLILNFAGWAFSFAYIG---SATDLTFASENIFITTF-----VMGLVELPTGPLSGIMANKLGRKKSVS---ALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGS-----------IFAPMIHSVLLQFY--FAGPFXXXXXXXXXXXXXXFAFI-PETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPSKQLDTEFDKFLL*LGLFACI*MTSFRIDETEYECTNHLGQL 1870
P +D+E + IGGC + ++ +++ + + + + +Y+P+F C+V KNIS NS +D C +YR +++++W KC + FEK M T++ + NLVCD F + + ++ + +GC+ I SD IG++ +I LS+++ G + + + L++ +S +C AYT +EI + + + ++ GY +AL AY+ +SW+ I +++ +++ +PE+PRWLM+ R +EA + + + N CT +K + K ++ GK F +L K + YR + + A + Y G + +D + +F F + G +E+PT + + +LGRKK++ SGL II ++ S+ S L + K+ A+ I I T+EL PT RNTA+ + + GS I P++ ++ + FAG + F+ PET P+P+T++ A++ L P+KQ++ +F G+F MT I TE TN + L
Sbjct: 194 PTDPIDFEGILNIIGGCRWWQIWIYVLIALQQIPHAMFNLNVVYMMYDPEFQCMVPGFNDTNDTTISSHGPYLWGVDDIKNISFVFPNANSDGAYQRDSCYFYERSEERYRQLRRMPLETAMSEAWKDVAPKKKCQAYHFEKDVMVETIVTDFNLVCDSWFAKGHAHMFYSIGYLLGCVLG---GIASDKIGRKPTIIGFGILSSML--GVFLPFNDYYPMFLLIRLLSAICNEAADLAAYTLCMEITGTKYRAMVGSMLQAPWALGYALLALIAYLTKSWKTIQVIAAGLHFMSIIFICSIPESPRWLMVQNRVSEAEEVIRKACREPPFPFNMCTTSKCGNLPSDLELVSHRERKLNKKNGGKIGFLDLFTMKELRYRTISVCIVFMATALVYYGLVMALSDQSAPGRTLFTGYFHLNNGIAGAIEIPTL-FACVWMMQLGRKKALMLTLITSGLFIIVAML-------SMVS-GHYMLALAFMYFGKIAVQGAFNILYIFTSELYPTVVRNTAVGVTSMVARFGSGLSSYIALLSNISLPIVPMIIFAVFSLFAG---------------MLVFVLPETSEKPLPETLDDAINFL----------------------EPTKQVNCMMGRF----GVFGHQKMTK-SISLTENPSTNDIADL 801
BLAST of slc22a-2 vs. Ensembl Celegans
Match: K05F1.6 (pep chromosome:WBcel235:II:5782942:5787658:1 gene:WBGene00019408.1 transcript:K05F1.6c.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:K05F1.6) HSP 1 Score: 120.168 bits (300), Expect = 5.767e-28 Identity = 152/664 (22.89%), Postives = 273/664 (41.11%), Query Frame = 2
Query: 167 PFTGMDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLV------------------------KNISSTI--RNSTNLISKDQC--------QYR--------LSVNDSWN------KCDQWTFEKRFMRNTLINELNLVCDRAF---YRELIFT-TFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQ--LVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAK-----INKCTLNK----------EEFNKWKPIQQVTGK--FWNLLKHKTMIYRFLILNFAGWAFSFAYIG---SATDLTFASENIFITTF-----VMGLVELPTGPLSGIMANKLGRKKSVS---ALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGS-----------IFAPMIHSVLLQFY--FAGPFXXXXXXXXXXXXXXFAFI-PETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPSKQLDTEFDKFLL*LGLFACI*MTSFRIDETEYECTNHLGQL 1870
P +D+E + IGGC + ++ +++ + + + + +Y+P+F C+V KNIS NS +D C +YR +++++W KC + FEK M T++ + NLVCD F + + ++ + +GC+ I SD IG++ +I LS+++ G + + + L++ +S +C AYT +EI + + + ++ GY +AL AY+ +SW+ I +++ +++ +PE+PRWLM+ R +EA + + + N CT +K + K ++ GK F +L K + YR + + A + Y G + +D + +F F + G +E+PT + + +LGRKK++ SGL II ++ S+ S L + K+ A+ I I T+EL PT RNTA+ + + GS I P++ ++ + FAG + F+ PET P+P+T++ A++ L P+KQ++ +F G+F MT I TE TN + L
Sbjct: 196 PTDPIDFEGILNIIGGCRWWQIWIYVLIALQQIPHAMFNLNVVYMMYDPEFQCMVPGFNDTNDTTISSHGPYLWGVDDIKNISFVFPNANSDGAYQRDSCYFYERSEERYRQLRRMPLETAMSEAWKDVAPKKKCQAYHFEKDVMVETIVTDFNLVCDSWFAKGHAHMFYSIGYLLGCVLG---GIASDKIGRKPTIIGFGILSSML--GVFLPFNDYYPMFLLIRLLSAICNEAADLAAYTLCMEITGTKYRAMVGSMLQAPWALGYALLALIAYLTKSWKTIQVIAAGLHFMSIIFICSIPESPRWLMVQNRVSEAEEVIRKACREPPFPFNMCTTSKCGNLPSDLELVSHRERKLNKKNGGKIGFLDLFTMKELRYRTISVCIVFMATALVYYGLVMALSDQSAPGRTLFTGYFHLNNGIAGAIEIPTL-FACVWMMQLGRKKALMLTLITSGLFIIVAML-------SMVS-GHYMLALAFMYFGKIAVQGAFNILYIFTSELYPTVVRNTAVGVTSMVARFGSGLSSYIALLSNISLPIVPMIIFAVFSLFAG---------------MLVFVLPETSEKPLPETLDDAINFL----------------------EPTKQVNCMMGRF----GVFGHQKMTK-SISLTENPSTNDIADL 803
BLAST of slc22a-2 vs. Ensembl Celegans
Match: K05F1.6 (pep chromosome:WBcel235:II:5782524:5787658:1 gene:WBGene00019408.1 transcript:K05F1.6c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:K05F1.6) HSP 1 Score: 120.168 bits (300), Expect = 5.767e-28 Identity = 152/664 (22.89%), Postives = 273/664 (41.11%), Query Frame = 2
Query: 167 PFTGMDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLV------------------------KNISSTI--RNSTNLISKDQC--------QYR--------LSVNDSWN------KCDQWTFEKRFMRNTLINELNLVCDRAF---YRELIFT-TFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQ--LVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAK-----INKCTLNK----------EEFNKWKPIQQVTGK--FWNLLKHKTMIYRFLILNFAGWAFSFAYIG---SATDLTFASENIFITTF-----VMGLVELPTGPLSGIMANKLGRKKSVS---ALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGS-----------IFAPMIHSVLLQFY--FAGPFXXXXXXXXXXXXXXFAFI-PETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPSKQLDTEFDKFLL*LGLFACI*MTSFRIDETEYECTNHLGQL 1870
P +D+E + IGGC + ++ +++ + + + + +Y+P+F C+V KNIS NS +D C +YR +++++W KC + FEK M T++ + NLVCD F + + ++ + +GC+ I SD IG++ +I LS+++ G + + + L++ +S +C AYT +EI + + + ++ GY +AL AY+ +SW+ I +++ +++ +PE+PRWLM+ R +EA + + + N CT +K + K ++ GK F +L K + YR + + A + Y G + +D + +F F + G +E+PT + + +LGRKK++ SGL II ++ S+ S L + K+ A+ I I T+EL PT RNTA+ + + GS I P++ ++ + FAG + F+ PET P+P+T++ A++ L P+KQ++ +F G+F MT I TE TN + L
Sbjct: 196 PTDPIDFEGILNIIGGCRWWQIWIYVLIALQQIPHAMFNLNVVYMMYDPEFQCMVPGFNDTNDTTISSHGPYLWGVDDIKNISFVFPNANSDGAYQRDSCYFYERSEERYRQLRRMPLETAMSEAWKDVAPKKKCQAYHFEKDVMVETIVTDFNLVCDSWFAKGHAHMFYSIGYLLGCVLG---GIASDKIGRKPTIIGFGILSSML--GVFLPFNDYYPMFLLIRLLSAICNEAADLAAYTLCMEITGTKYRAMVGSMLQAPWALGYALLALIAYLTKSWKTIQVIAAGLHFMSIIFICSIPESPRWLMVQNRVSEAEEVIRKACREPPFPFNMCTTSKCGNLPSDLELVSHRERKLNKKNGGKIGFLDLFTMKELRYRTISVCIVFMATALVYYGLVMALSDQSAPGRTLFTGYFHLNNGIAGAIEIPTL-FACVWMMQLGRKKALMLTLITSGLFIIVAML-------SMVS-GHYMLALAFMYFGKIAVQGAFNILYIFTSELYPTVVRNTAVGVTSMVARFGSGLSSYIALLSNISLPIVPMIIFAVFSLFAG---------------MLVFVLPETSEKPLPETLDDAINFL----------------------EPTKQVNCMMGRF----GVFGHQKMTK-SISLTENPSTNDIADL 803
BLAST of slc22a-2 vs. Ensembl Fly
Match: CG8654 (gene:FBgn0034479 transcript:FBtr0086340) HSP 1 Score: 140.969 bits (354), Expect = 1.422e-35 Identity = 112/446 (25.11%), Postives = 204/446 (45.74%), Query Frame = 2
Query: 383 QCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKC---TLNKE------EFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQE 1690
C+ + ++C + F+ ++T+I E NL C+ L + +G LF S F + +D G+R + F+ I + VS W + F+ V + ++ ++ L+EI+ ++ A + ++ G+ S+ALFAY R WR I SI +V+Y W VPE+PRWL + +++ K + IAK NK T+ E +P+++ G +L + M + + + Y G+A ++ NIFI+ + V +P L +M LGRKK++ +G + LI++ + + ++V + L GA + F + +L EL PT R++ + L + +GSI AP+I + + P + +L + + F+PET P+P+T+E + K+ +
Sbjct: 66 SCKTENVTDPCSDECSETEFDTSVFQSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALAARQPVKK--GTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQA-EAVRVTCATIGL-FGASITFPNVYL----YGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTI--FLPETRGTPLPETLEDGETFGRKKKDQ 501
BLAST of slc22a-2 vs. Ensembl Fly
Match: CG8654 (gene:FBgn0034479 transcript:FBtr0305676) HSP 1 Score: 140.969 bits (354), Expect = 1.422e-35 Identity = 112/446 (25.11%), Postives = 204/446 (45.74%), Query Frame = 2
Query: 383 QCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKC---TLNKE------EFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQE 1690
C+ + ++C + F+ ++T+I E NL C+ L + +G LF S F + +D G+R + F+ I + VS W + F+ V + ++ ++ L+EI+ ++ A + ++ G+ S+ALFAY R WR I SI +V+Y W VPE+PRWL + +++ K + IAK NK T+ E +P+++ G +L + M + + + Y G+A ++ NIFI+ + V +P L +M LGRKK++ +G + LI++ + + ++V + L GA + F + +L EL PT R++ + L + +GSI AP+I + + P + +L + + F+PET P+P+T+E + K+ +
Sbjct: 66 SCKTENVTDPCSDECSETEFDTSVFQSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALAARQPVKK--GTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQA-EAVRVTCATIGL-FGASITFPNVYL----YGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTI--FLPETRGTPLPETLEDGETFGRKKKDQ 501
BLAST of slc22a-2 vs. Ensembl Fly
Match: CG8654 (gene:FBgn0034479 transcript:FBtr0342667) HSP 1 Score: 140.969 bits (354), Expect = 1.422e-35 Identity = 112/446 (25.11%), Postives = 204/446 (45.74%), Query Frame = 2
Query: 383 QCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKC---TLNKE------EFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQE 1690
C+ + ++C + F+ ++T+I E NL C+ L + +G LF S F + +D G+R + F+ I + VS W + F+ V + ++ ++ L+EI+ ++ A + ++ G+ S+ALFAY R WR I SI +V+Y W VPE+PRWL + +++ K + IAK NK T+ E +P+++ G +L + M + + + Y G+A ++ NIFI+ + V +P L +M LGRKK++ +G + LI++ + + ++V + L GA + F + +L EL PT R++ + L + +GSI AP+I + + P + +L + + F+PET P+P+T+E + K+ +
Sbjct: 66 SCKTENVTDPCSDECSETEFDTSVFQSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALAARQPVKK--GTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQA-EAVRVTCATIGL-FGASITFPNVYL----YGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTI--FLPETRGTPLPETLEDGETFGRKKKDQ 501
BLAST of slc22a-2 vs. Ensembl Fly
Match: CG8654 (gene:FBgn0034479 transcript:FBtr0305677) HSP 1 Score: 140.969 bits (354), Expect = 1.422e-35 Identity = 112/446 (25.11%), Postives = 204/446 (45.74%), Query Frame = 2
Query: 383 QCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKC---TLNKE------EFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQE 1690
C+ + ++C + F+ ++T+I E NL C+ L + +G LF S F + +D G+R + F+ I + VS W + F+ V + ++ ++ L+EI+ ++ A + ++ G+ S+ALFAY R WR I SI +V+Y W VPE+PRWL + +++ K + IAK NK T+ E +P+++ G +L + M + + + Y G+A ++ NIFI+ + V +P L +M LGRKK++ +G + LI++ + + ++V + L GA + F + +L EL PT R++ + L + +GSI AP+I + + P + +L + + F+PET P+P+T+E + K+ +
Sbjct: 66 SCKTENVTDPCSDECSETEFDTSVFQSTIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCNKAPTETIRPEIEAAYGALAARQPVKK--GTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAGVGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQA-EAVRVTCATIGL-FGASITFPNVYL----YGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGTI--FLPETRGTPLPETLEDGETFGRKKKDQ 501
BLAST of slc22a-2 vs. Ensembl Fly
Match: Orct (gene:FBgn0019952 transcript:FBtr0334870) HSP 1 Score: 133.65 bits (335), Expect = 8.101e-33 Identity = 124/528 (23.48%), Postives = 222/528 (42.05%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLT--FALYEPKFSCLVKNISSTIRN------STNLISKDQCQY----------RLSVNDSWNK---CDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKW------------KPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQA 1660
M Y+ + +G G + + L + V F L F L +P F C + + +I + + ++C Y S+ S N+ C + +++ N+ + E NLVC R+ + F +G L S F +SD +G++ S+ L I + V+ + + + + G S +AY +E++ S+ A +S G+M A FAY WR + I + + ++ Y+W +PE+ RWL++ R++EAF + AK NK + E + + Q ++LL++ + + L++ F + S Y G + + N + + G VE+P L N+ GR+ + + I L+ F+ +D WL V AM KL +S++ I + E PT RN + + +G I AP + +L + + P ++ L L +L +PET + P+P+TIE
Sbjct: 1 MGYDDVITHLGEFGPYQKRIYYLLCLPAI--VCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHLWNLSYPENERCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSD------MNWLIVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLK-LLGEIWRPLPLIICGALSLTAGLLS-LLLPETLNKPMPETIEDG 518
BLAST of slc22a-2 vs. Ensembl Zebrafish
Match: oatx (organic anion transporter X [Source:ZFIN;Acc:ZDB-GENE-070115-1]) HSP 1 Score: 137.887 bits (346), Expect = 4.513e-34 Identity = 142/554 (25.63%), Postives = 237/554 (42.78%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISK--------------------------DQCQYRLSVNDSWNKC-DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKIN-------KCTLNKEEFNKWKPIQQVTGKF--WNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLII-MPFIEADSLKSVWQPWLKVCLAMGAKLGFSSA-WLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKL 1726
M + L ++GG G F I LSI + F P+ C + N+++ + +ST + + D+ + + C D WT++K +++++E LVCD + L S P + S G++ LLI S F ++ ++ + F++G+ S + A + +E IP L T ++FG M +A AY R WR+I + + + +Y W+ E+ RWL+LN R EA K + +AKIN K TL + E + K +Q + ++LL+ TM + L ++ SFAY G A DL NI++ + G V+ P ++ +M + LGR+ + A CL++ I A+ + LA+ K GF+SA + + T EL PT R T M V +GS+ AP + +L A P ++Y +I ++ F +PET ++P+P TI+ E++W KL
Sbjct: 1 MGFADLLDEVGGFGRFQMIHVTLLSIPGLLMASQNLLNNFTAGVPEHHCRIPNVTTAMNDSTTTLLRAFIPLDSSLTLSKCSRYKDTQWHLITDKLSHGNATELQTEGCADGWTYDKSEFISSIVSESTLVCDTESKLLCFMNVYIEKVLNSIPGGVFSCRFGRKALLIWSYFQLALLGSFTALAPSYVVYCIFRFLTGMSVSGVILNAVSLKVEWIPTKTRTLVGTLSSFFFTFGQMVLAGVAYSLRDWRKIQMAVCLPFFIFFMYSWWFSESARWLVLNGRSEEALKLLHRVAKINGKPEMTEKITLEELESHMQKEVQSSKSIYTVFDLLRTPTMRKISMCLMVVWFSTSFAYYGLAMDLQKFGVNIYLMQVIFGAVDFPAKLVALLMLSFLGRRLTQGA-------CLLVSASIIFANIFVPEDMQVTRTALAVLGK-GFTSASFTCVYLFTGELYPTVIRQTGMGFVSTMSRIGSMAAPAVL-ILDDILPALPSIVYGGSAVIAGLIAF-LLPETLNIPLPDTIDDV-------EEKWYFRKFGSTSKL 537
BLAST of slc22a-2 vs. Ensembl Zebrafish
Match: slc22a2 (solute carrier family 22 member 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2167]) HSP 1 Score: 135.191 bits (339), Expect = 4.227e-33 Identity = 121/465 (26.02%), Postives = 204/465 (43.87%), Query Frame = 2
Query: 374 SKDQCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNK--EEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPSKQLD 1759
D Q +LSV + D W ++ R + + E +LVC A+Y ++ T +G L S L+D G+ +++ F + I S LV + G + Y + E++ V H + +S G + + L AY +WR + ++ + I ++ Y+WF+PE+PRWL+ + EA + IAK N+ TL+K E T F +L K + IL+F + + Y G L N+++ + G+VELP L + ++GR+ + + + +I FI DS+ WLK +A +LG + A+ + + EL PT RN +S+ +G I AP + L + P +++ L + LV +PET +P+P+TI+ +KE + QQ E L M +K D
Sbjct: 106 DGDFNQSQLSVMPMMSCVDGWEYDY-VGRQSFVTEFDLVCGDAWYVDMFQATLSIGFLVGSIAIGYLADKYGRMKSFLMTNFFIGVTGILVATSPNYISLLVFRALFGFGVKGGWMVGYVLITELVGVDHRRTVGVTYQLFFSMGILLLPLLAYFITNWRWLQVVFTVPYICFLTYYWFIPESPRWLLTQNKIAEAVEITKSIAKENRKTLSKKIETLKDDNIDSGSTASFMDLFKTAKLRTYTFILSFNWFTSAVVYQGLIMRLGILGGNVYVDFLISGIVELPAAFLILLTIERIGRRLPFATANIVAGAACLITAFI-PDSMF-----WLKSAVACVGRLGITMAFEMVVFVNTELYPTVIRNLGVSVCSTLCDVGGIVAPFLLYRLAVIWLELPLIIFGALAFVAGGLVL-LLPETKGVPLPETIDDIEHPNRNKENPQQS---QQLENL-MTSDVTKNKD 558
BLAST of slc22a-2 vs. Ensembl Zebrafish
Match: slc22a21 (solute carrier family 22 member 21 [Source:ZFIN;Acc:ZDB-GENE-091118-62]) HSP 1 Score: 133.265 bits (334), Expect = 1.226e-32 Identity = 140/532 (26.32%), Postives = 244/532 (45.86%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVK---NISSTIRNSTNLISKDQCQ--------YRLSVNDSWN--------------------KC-DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFS-ILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQL-VLSFVSGVCK-SVYVSLAYTTLIEIIPVSHIDLAAT-NFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTG----KFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQ 1657
DYE A +G G F F L ++ + F P C + N+++ RN++ + + Q YRL ++ N +C D W ++K +T+++E +LVC + L + FF G L S +SD G++++L V++ + T+ T+ Q+ S WQ +L F+ G+ + S YV+ A+ +EI+ S D+ +T +S GYM + L A+ R WR + + I FY+ +WF+PE+PRWL+ R EA + AKIN+ T F + + G LLK + Y +L A S Y + + + NI++ + +VE+P ++ +M R+ +++ LG + L+++ I D Q + + L M K G S+A+ I +T EL PT RNTA+ ++ +G I AP + L ++ + P++L + +++ +L F +PE+ +P+TI Q
Sbjct: 5 DYEEQTAFLGAWGPFQKTVFSLLCLSIIPNGFTGLSIVFLGDTPAHHCRIPETLNLTAGWRNAS--VPRPQPHGDPRASRCYRLRLDLVKNYSDGGLLPGLDVNVSEIPREECADGWIYDKEIYSSTIVSEWDLVCSDDWKSPLTSSIFFCGVLTGSVISGPVSDRFGRKIVLFVTMAIQTLFTVVQVFSPS-WQIFCLLFFIVGMGQISNYVA-AFVLGMEILSSSVRDVYSTLGVCLFFSIGYMILPLAAFFLRDWRSLMLALTIPGFFYIPLWWFIPESPRWLLSQGRVQEAEAIIRKAAKINRVTAPDVIFPLMQSTEDAGGVQSFSVCELLKSSNIRYMTGLLCLIWMAVSIGYCALSLNTSSLHGNIYLNCLLSAVVEVPALLMAWLMLRLAPRRHCLASTLALGGLVLLLILLIPED------QSSVTLALVMLGKFGLSAAFSIIYPVTAELYPTVLRNTALGACSMSSRVGGISAPYFN-YLGSYHRSLPYILIGGINVLSGLLSF-LLPESRGSALPETIGQ 524
BLAST of slc22a-2 vs. Ensembl Zebrafish
Match: slc22a21 (solute carrier family 22 member 21 [Source:ZFIN;Acc:ZDB-GENE-091118-62]) HSP 1 Score: 133.265 bits (334), Expect = 1.397e-32 Identity = 140/532 (26.32%), Postives = 244/532 (45.86%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVK---NISSTIRNSTNLISKDQCQ--------YRLSVNDSWN--------------------KC-DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFS-ILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQL-VLSFVSGVCK-SVYVSLAYTTLIEIIPVSHIDLAAT-NFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTG----KFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQ 1657
DYE A +G G F F L ++ + F P C + N+++ RN++ + + Q YRL ++ N +C D W ++K +T+++E +LVC + L + FF G L S +SD G++++L V++ + T+ T+ Q+ S WQ +L F+ G+ + S YV+ A+ +EI+ S D+ +T +S GYM + L A+ R WR + + I FY+ +WF+PE+PRWL+ R EA + AKIN+ T F + + G LLK + Y +L A S Y + + + NI++ + +VE+P ++ +M R+ +++ LG + L+++ I D Q + + L M K G S+A+ I +T EL PT RNTA+ ++ +G I AP + L ++ + P++L + +++ +L F +PE+ +P+TI Q
Sbjct: 5 DYEEQTAFLGAWGPFQKTVFSLLCLSIIPNGFTGLSIVFLGDTPAHHCRIPETLNLTAGWRNAS--VPRPQPHGDPRASRCYRLRLDLVKNYSDGGLLPGLDVNVSEIPREECADGWIYDKEIYSSTIVSEWDLVCSDDWKSPLTSSIFFCGVLTGSVISGPVSDRFGRKIVLFVTMAIQTLFTVVQVFSPS-WQIFCLLFFIVGMGQISNYVA-AFVLGMEILSSSVRDVYSTLGVCLFFSIGYMILPLAAFFLRDWRSLMLALTIPGFFYIPLWWFIPESPRWLLSQGRVQEAEAIIRKAAKINRVTAPDVIFPLMQSTEDAGGVQSFSVCELLKSSNIRYMTGLLCLIWMAVSIGYCALSLNTSSLHGNIYLNCLLSAVVEVPALLMAWLMLRLAPRRHCLASTLALGGLVLLLILLIPED------QSSVTLALVMLGKFGLSAAFSIIYPVTAELYPTVLRNTALGACSMSSRVGGISAPYFN-YLGSYHRSLPYILIGGINVLSGLLSF-LLPESRGSALPETIGQ 524
BLAST of slc22a-2 vs. Ensembl Zebrafish
Match: slc22a4 (solute carrier family 22 member 4 [Source:ZFIN;Acc:ZDB-GENE-040426-1517]) HSP 1 Score: 132.109 bits (331), Expect = 4.272e-32 Identity = 143/538 (26.58%), Postives = 242/538 (44.98%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGL--TFALYEPKFSCLVK---NISSTIRNST-------NLISKDQC-QYRLS---------------VNDSW---NKC-DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQ--QLVLSFVSGVCKSVYVSLAYTTLIEII-PVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGK------FWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSL 1669
DY+ + + +G G F F+ L+I+ F GL F P CL+ NISS R++ ++ + C +YRL VN S C D W++ + F ++T++ E +LVC+R + L + +F G L +F +SD G+R +L + L TI + QM S W+ + FV S YV +AY EI+ P S + + + G M L AY RSWR + + + +T + Y +WF+PE+PRWL+ R EA + A+ N+ T + F+ I++ K ++L + + LI + + +Y + T N ++ F+ +VE+P ++ ++ R+ ++ LG + I+ I + L+ L L M KL ++A+ + +T+EL PT RN AM +T +GSI +P I L +Y P+++ L L + V+ +PE+ +P+TI Q S+
Sbjct: 3 DYDDITSFLGTWGQFQLTVFLALAISILPN--GFVGLYIVFVGDTPAHECLIPEQINISSVWRDAAIPTQMQDGVLKRSSCSRYRLDTLRQLSMLNYTPNVEVNLSQIETEPCVDGWSYSQEFYQSTIVTEWDLVCEREYKGPLTSSIYFCGVLVGTFLSGQMSDRYGRRPVLFAMMALQTITILIQMFSPS-WEVFSAIYFFVGFSGFSNYV-VAYVLGSEILSPASRVLFGSLGVFMGSGIGQMFFPLAAYFIRSWRWLVLTNALTGLLYFPLWWFIPESPRWLLSQGRTAEAEAVLRRAAEKNRVTAPEVIFSS-SEIEEAAKKRIQKHSILDILSNCNAVSTILICSLLWMVITMSYYALILNTTNLHGNPYLNFFLSAVVEVPAYIIAALLLRFCSRRICQASTLLLGGALIFIIQLIPTE-LQG-----LSTALEMLGKLCVTAAFCVVYAVTSELFPTVVRNMAMGSCSMTARIGSIISPFII-YLGNYYRYIPYIVIGGLALFSGVMSL-LLPESKGKVLPETIAQMQSV 527
BLAST of slc22a-2 vs. Ensembl Xenopus
Match: emc2 (ER membrane protein complex subunit 2 [Source:Xenbase;Acc:XB-GENE-484487]) HSP 1 Score: 135.191 bits (339), Expect = 4.768e-33 Identity = 142/546 (26.01%), Postives = 238/546 (43.59%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLT--FALYEPKFSCLVK---NISSTIRNSTNLISKD----QCQ-YRLSVNDSWNKC-------------------DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFV-SGVCK-SVYVSLAYTTLIEIIPVS-HIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCT-----LNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWA-FSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMI-----HSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQ 1687
DY+ A +G G F F LS + F GL+ F P+ C V N+S+ RN++ + +D QC+ YRL +++ D W + K +T++ E NLVC+ + L + FFVG L SF +SD G++ +L ++ + T +I Q+ S W+ F+ G+ + S YV+ A+ EI+ S I + Y+ GYM + LFAY R WR + + I +F + +W +PE+PRWL+ R EA + AK N T N E + K + + F +LLK + I L+ W S Y G + + + ++ F+ ++E+P ++ ++ R+ S ++ LG + L+ + + + L + L M K G +SA+ + + T EL PT RN + + +GSI +P + L F G + + + +PE+H +P+P TIE+ L + EQ
Sbjct: 3 DYDQATAFLGEWGPFQVSVFFLLSASIIPN--GFTGLSAVFLAATPEHRCHVPESANLSAAWRNAS-IPRQDGQDSQCRRYRLGTLTNYSALGLLPGRDVDVTGIEQEPCLDGWNYSKSLYLSTIVTEWNLVCENDWKGPLTTSLFFVGVLIGSFVSGQMSDRFGRKKVLFATMAVQTGFSIIQVFSVN-WEMFTALFIIVGMGQISNYVA-AFILGAEILDKSVRIIFSTLGVCIFYAIGYMLLPLFAYFIRDWRTLLLALTIPGLFCIPLWWIIPESPRWLISQGRFQEAEDIIRKAAKKNGITPPDSIFNFTELQEQKELTHKSHTFLDLLKTRN-IRIITFLSILLWMIISVGYFGLSLNTPNLHGDPYVNCFLSAIIEVPAYVIAWLLLRSFPRRYSTASTLVLGGVVLLFIQLVPQE------LGILSIVLVMLGKFGITSAFSMVYVYTAELYPTVVRNMGVGASSMASRMGSILSPYFVYLGAYDRFLPFILMGSLTVLIGMFTLC-------LPESHGMPLPDTIEEM--LRVKGEQ 527
BLAST of slc22a-2 vs. Ensembl Xenopus
Match: emc2 (ER membrane protein complex subunit 2 [Source:Xenbase;Acc:XB-GENE-484487]) HSP 1 Score: 134.806 bits (338), Expect = 5.694e-33 Identity = 139/536 (25.93%), Postives = 234/536 (43.66%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLT--FALYEPKFSCLV---KNISSTIRNSTNLISKD----QCQ-YRLSVNDSWNKC-------------------DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFV-SGVCK-SVYVSLAYTTLIEIIPVS-HIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCT-----LNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWA-FSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMI-----HSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQ 1657
DY+ A +G G F F LS + F GL+ F P+ C V N+S+ RN++ + +D QC+ YRL +++ D W + K +T++ E NLVC+ + L + FFVG L SF +SD G++ +L ++ + T +I Q+ S W+ F+ G+ + S YV+ A+ EI+ S I + Y+ GYM + LFAY R WR + + I +F + +W +PE+PRWL+ R EA + AK N T N E + K + + F +LLK + I L+ W S Y G + + + ++ F+ ++E+P ++ ++ R+ S ++ LG + L+ + + + L + L M K G +SA+ + + T EL PT RN + + +GSI +P + L F G + + + +PE+H +P+P TIE+
Sbjct: 3 DYDQATAFLGEWGPFQVSVFFLLSASIIPN--GFTGLSAVFLAATPEHRCHVPESANLSAAWRNAS-IPRQDGQDSQCRRYRLGTLTNYSALGLLPGRDVDVTGIEQEPCLDGWNYSKSLYLSTIVTEWNLVCENDWKGPLTTSLFFVGVLIGSFVSGQMSDRFGRKKVLFATMAVQTGFSIIQVFSVN-WEMFTALFIIVGMGQISNYVA-AFILGAEILDKSVRIIFSTLGVCIFYAIGYMLLPLFAYFIRDWRTLLLALTIPGLFCIPLWWIIPESPRWLISQGRFQEAEDIIRKAAKKNGITPPDSIFNFTELQEQKELTHKSHTFLDLLKTRN-IRIITFLSILLWMIISVGYFGLSLNTPNLHGDPYVNCFLSAIIEVPAYVIAWLLLRSFPRRYSTASTLVLGGVVLLFIQLVPQE------LGILSIVLVMLGKFGITSAFSMVYVYTAELYPTVVRNMGVGASSMASRMGSILSPYFVYLGAYDRFLPFILMGSLTVLIGMFTLC-------LPESHGMPLPDTIEE 519
BLAST of slc22a-2 vs. Ensembl Xenopus
Match: bub1b (BUB1B, mitotic checkpoint serine/threonine kinase [Source:Xenbase;Acc:XB-GENE-1010857]) HSP 1 Score: 131.724 bits (330), Expect = 6.506e-32 Identity = 132/545 (24.22%), Postives = 236/545 (43.30%), Query Frame = 2
Query: 185 YEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNIS------------STIRNSTNLISKDQC-QYRLSVNDSWNKC-----------------DQWTFEKRFMRNTLINELNLVCDRA----FYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSG-VCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKIN---------KCTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKS-VSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKE 1684
++ L IG F F+ L + + + G+ F + P + C+ I + ST+ + QC QY + N + C D W + ++L+ E NLVC + F++ + FF+G L S ++D G++ LI SI ++ I I + + F+ G V K ++S Y + E + + H + ++ G + ++ AY+ WR + + I F++ Y+W VPE+PRWL+ R+ EA + IAK N T ++E K P F +L++ + LIL + + + Y GS + +ENI+ F+ LVE P+ L + +++GR+ + GI CLI S WL + L+ +++G + ++ + ++ EL PT RN + + LG + P I L + P +++++L ++ +LV+ F+PET +P+TIE+A +L HK+
Sbjct: 4 FDELLEHIGEFDAFQKQIFILLCFISVVFSPIYVGIVFLGFVPDYRCVSAGIPEPSNECEWTLNYTGPNGSTDSLYMSQCYQYDVDWNSTSLNCTNSSLNITSKLPITNCKDGWDYNTT--GSSLVTEFNLVCGDSWKLDFFQSCVNIGFFIGGLIS---GYIADRFGRKPFLISSILITGIFGILMAFAPNYPLVVTFRFIQGFVSKGCWLS-GYILVAEFVGLEHRRTVGIVYQAAFTVGLLLLSGVAYVLPHWRWLQMTVTIPYFFFLAYYWCVPESPRWLISQNRKAEAKAIIHTIAKKNGKMVPDFLESLTADEEAGEKQVP------SFLDLVRTPQIRKHTLILMYIWFTCAVVYQGSIMHMGSTAENIYFDFFISALVEFPSAILIIVTVDRVGRRYPWLVCCIITGITCLITAFIPHGYS-------WLIITLSCVSRMGITVSYEMVCLVNAELYPTFIRNLGIMVCSSMCDLGGVITPFIVYRLAAIWQELPLIVFAVLATVSGILVY-FLPETKGRALPETIEEAENL--HKQ 526
BLAST of slc22a-2 vs. Ensembl Xenopus
Match: slc22a4 (solute carrier family 22 (organic cation/zwitterion transporter), member 4 [Source:NCBI gene;Acc:394948]) HSP 1 Score: 127.872 bits (320), Expect = 1.266e-30 Identity = 127/533 (23.83%), Postives = 233/533 (43.71%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLV---KNISSTIRNSTNLISKD----QCQ-YRLSVNDSWNKC-------------------DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSF-VSGVCK-SVYVSLAYTTLIEIIPVS-HIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCT-----LNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMI-----HSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQ 1657
DY+ + +G G + ++ F LS + + F P+ C + N+S+ RN++ + +D QC+ YRL +++ D W + K +T++ E ++VC+ + L + FFVG L SF LSDS G++ +L V++ + T +I Q+ S W+ + F + G+ + S YV+ A+ EI+ S I + ++ GYM + LFAY R WR + + I +F + +W +PE+P+WL+ R EA + AKIN+ E Q+ + +L+K + ++ F S Y G + + + ++ F+ ++E+P ++ ++ R+ S ++ LG + L+ + + + L + L M K G +SA+ + + T EL PT RN + + +GSI +P + L F G + + + +PE+H +P+P TIE+
Sbjct: 3 DYDEATSFLGEWGRYQFMIFFLLSASIIPNGFNGMSVMFLAGIPEHRCHIPESANLSAAWRNAS-IPRQDGQDSQCRRYRLGTLTNYSALGLLPGRDVDVTGIEQEPCLDGWNYSKSLYLSTIVTEWDIVCENDWKGPLTTSLFFVGVLLGSFVSGQLSDSFGRKKILFVTMAIQTGFSIVQVFSTS-WEMFAIFFLIVGMGQISNYVA-AFILGTEILGKSARIIFSTLGTCIFFAIGYMMLPLFAYFIRDWRTLLLALTIPGLFCIPLWWIIPESPQWLICKGRIEEAEVIIRKAAKINRVPAPAVIFKTTELEDLAERQKRSYTLLDLVKTFNVRIITIMTVFLWMIISVGYFGLSLNTPNLHGDPYVNCFLSAIIEVPAYVIAWLLLRSFPRRYSTASTLVLGGVVLLFIQLVPQE------LGILSIVLVMLGKFGITSAFSMVYVYTAELYPTVVRNMGVGASSMASRMGSILSPYFVYLGAYDRFLPFILMGSLTVLIGMFTLC-------LPESHGMPLPDTIEE 519
BLAST of slc22a-2 vs. Ensembl Xenopus
Match: ENSXETT00000009697.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:4:38350677:38358876:1 gene:ENSXETG00000001222.1 transcript:ENSXETT00000009697.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 127.102 bits (318), Expect = 1.402e-30 Identity = 132/507 (26.04%), Postives = 223/507 (43.98%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDS----WNKCDQ-WTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNK-----WKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSA-LSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFA--FIPETHHLPVPQTIEQ 1657
M + L K+G GLF ++ + LSI F+ P + C V N++ + + + CQ R++VND+ C W ++K +T++ E +LVC +EL + F G L + F LSD G+R +L+ S+F+ ++ G S + GV S + + +E++P L + G + +A AY R WR + + + + LY W++PE+ RWLM+N + A K + +AK+N KEE K K IQ+ +F ++ F + F ++ + +Y G + DL S + + G ++L + I + LGR+ S L G + L+ M I D P L++ + K S++ L + + EL PT R + M L + LG I +P V+L + PFL L + ++V F+PE H+ P+P TI++
Sbjct: 1 MAFSELVEKVGSMGLFQILTVIFLSIPVLFIYGHNLVQNFSAGVPGYHCRV-NVTDEFNPAVQRLGHEICQ-RVAVNDTGIVIMESCKTGWAYDKSIFSSTIVTEWDLVCGLESLKELAQSLFMAGVLLGALIFGHLSDRYGRRAILLCSLFMIGVMGTGAAFSPNFSTYCCFRLLLGVGLSGLLLNYFCLSLELVPPKSRTLVVAIQGYCSTSGQVLLAGLAYALRDWRWLQLAISLPFFIFFLYSWWLPESFRWLMVNNKPERALKNLQRVAKLNG---RKEEGQKISLEVRKGIQKGHKQFRLFTFFLKLM--FFLSPFYSFSINMSYFGLSMDLPVFSYGPHVVQVIFGGIDLVAKFMCTIALSFLGRRCVQSGTLFCAGALLLLTMA-IPQDF------PLLRIVFVVLGKGCLSASSLCSYLYSGELFPTVVRQSGMGLTTMMARLGGIVSP----VVLMARSSYPFLPLLLFGVSSIVSGITALFLPELHNAPLPDTIQE 489
BLAST of slc22a-2 vs. Ensembl Mouse
Match: Slc22a5 (solute carrier family 22 (organic cation transporter), member 5 [Source:MGI Symbol;Acc:MGI:1329012]) HSP 1 Score: 150.984 bits (380), Expect = 1.735e-38 Identity = 147/560 (26.25%), Postives = 246/560 (43.93%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVK---NISSTIRN-STNLISKDQCQ-------YRLSVNDSWNKC-------------------DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCK-SVYVSLAYTTLIEIIPVS-HIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKIN-----KCTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGW-AFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMI-----HSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLG 1729
DY+ + A +G G F + F LS + + F P+ CLV N+SS RN S L +KD Q YRL+ ++++ D W ++K +T++ E +LVC + L + FFVG L SF LSD G++ +L +++ + T + Q+ S VL + G+ + S YV+ A+ EI+ S I A Y+FG+M + LFAY R WR + + + + +WF+PE+PRWL+ R EA + AKIN + E + ++L++ + I I++ W S Y G + D +I++ F++ VE+P L+ ++ L R+ S+SA LG L+ M + ++ +L L M K G +SA+ + + T EL PT RN + + LGSI +P + L + G + + +L + F PE+ +P+P TI+Q L + ++W++ + +K G
Sbjct: 3 DYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLSSAWRNHSIPLETKDGRQVPQKCRRYRLATIANFSELGLEPGRDVDLEQLEQESCLDGWEYDKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGFSFLQVFSVNFEMFTVLFVLVGMGQISNYVA-AFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSELQDLNSTKPQLHHIYDLIRTRN-IRVITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVPSELF------YLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTL-------FFPESFGVPLPDTIDQM--LRVKGIKQWQIQSQTRMQKDG 545
BLAST of slc22a-2 vs. Ensembl Mouse
Match: Slc22a21 (solute carrier family 22 (organic cation transporter), member 21 [Source:MGI Symbol;Acc:MGI:1929481]) HSP 1 Score: 133.65 bits (335), Expect = 1.559e-32 Identity = 148/571 (25.92%), Postives = 254/571 (44.48%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLT--FALYEPKFSCLVK---NISSTIRN-STNLISKD------QCQ-YRLSVN-------------------DSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCK-SVYVSLAYTTLIEIIPVS-HIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKIN-----KCTLNKEEFNKWKPIQQVTGK------FWNLLKHKTMIYRFLILNFAGW-AFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPSK 1750
+DY+ + A +G G F + F LS + F GL+ F P+ C + N+SS RN S + +KD +C+ YRL+ + N D W ++K +T++ E +LVC + L + F+VG L SF LSD G++ +L +++ + T + Q+ S +L + G+ S YV+ A+ E++ S I A ++FG+M + LFAY R WR++ + + + +WF+PE+PRWL+ R EA + AKIN + E NK +Q + K ++L++ I I++ W S Y G + D + NI++ F++ VE+P L+ ++ + R+ S++ LG L+++ + +D +L L M K G +SA+ + + T EL PT RN + + LGSI +P + V L Y + L I ++ F PE+ + +P+TI++ + K+++ E G V R S+
Sbjct: 2 LDYDEVTAFLGEWGTFQRLIFFLLSASIIPN--GFTGLSAVFLTAIPEHRCRIPDTVNLSSAWRNHSIPMETKDGPEVPQKCRRYRLATIANFSELGLEPGRDVDLEQLEQENCLDGWEYDKDIFLSTIVTEWDLVCKDDWKAPLTTSFFYVGVLLGSFISGQLSDRFGRKNILFLTMAMHTGFSFIQVFSVNFEMFTLLYTLVGMGHISNYVA-AFVLGTEMLSKSVRIIFATLGVCIFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSETNK---LQDDSSKKPQSHHIYDLVRTPN-IRILTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSD------LHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSP--YFVYLGAYDRRLPYILMGSLTILTAIITLFFPESSGVSLPETIDEMQKVKKLKQRQSLSKKGSPKESKGNVSRTSR 557
BLAST of slc22a-2 vs. Ensembl Mouse
Match: Slc22a4 (solute carrier family 22 (organic cation transporter), member 4 [Source:MGI Symbol;Acc:MGI:1353479]) HSP 1 Score: 132.109 bits (331), Expect = 3.757e-32 Identity = 132/536 (24.63%), Postives = 239/536 (44.59%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVK---NISSTIRN-STNLISKDQCQ-------YRLSVNDSWN------------------KC-DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSF-VSGVCKSVYVSLAYTTLIEIIPVS-HIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCT-----LNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAF-SFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMI-----HSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQ 1657
DY+ + A +G G F + F LS + + F P+ CLV N+SS+ RN S L +KD Q YRL+ +++ C D W ++K +T++ E NLVC+ + L + FFVG L SF LSD G++ +L ++ + T + Q+ S W+ + F + G+ + +A+ EI+ S I + ++ GYM + LFAY R WR + + + +F V +WF+PE+PRWL+ +R EA + + AK+N + E + ++Q +L + + I ++ W S Y + ++ ++++ F+ GL+E+P + ++ L R+ ++ + G L+++ + D ++ + L M K G +SA+ + + T EL PT RN A+ + + +GSI AP ++ LL + G + ++ + F PE+ + +P+ +EQ
Sbjct: 3 DYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVPDTVNLSSSWRNHSIPLETKDGRQVPQSCRRYRLATIANFSAMGLEPGQDVDLEQLEQESCLDGWEYDKDIFLSTIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFATMAVQTGFSFVQIFSTN-WEMFTVLFAIVGMGQISNYVVAFILGTEILSKSVRIIFSTLGVCTFFAIGYMVLPLFAYFIRDWRMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFAEAEQIIQKAAKMNSIVAPAGIFDPLELQELNSLKQQKVIILDLFRTRN-IATITVMAVMLWMLTSVGYFALSLNVPNLHGDVYLNCFLSGLIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLLIQVVPED------YNFVSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGSLTVLIGIITL-------FFPESFGVTLPENLEQ 523
BLAST of slc22a-2 vs. Ensembl Mouse
Match: Slc22a1 (solute carrier family 22 (organic cation transporter), member 1 [Source:MGI Symbol;Acc:MGI:108111]) HSP 1 Score: 129.413 bits (324), Expect = 3.611e-31 Identity = 123/514 (23.93%), Postives = 229/514 (44.55%), Query Frame = 2
Query: 188 EHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRA----FYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSG-VCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINK---------CTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQ 1687
E LN + G G SF++ KY V++ T +P +SS N ++L C++ W ++ ++++ E NLVC A ++ + FF+G L ++D G++L L+V+ ++++ + V+ L+ + G V K +VS YT + E + + A + ++ G + +A AY WR + + + + ++LY+WFVPE+PRWL+ KR +A + M IA+ N+ L ++ + P F +L + ++ LIL + ++ + Y G + N+++ F LVE P + + +++GR ++A + + ++M FI + WL V LA ++G + + ++ EL PT RN M + LG IF P + L++ + A P +L+ +L L + +PET + +P+TIE+A +L K +
Sbjct: 68 EELNYTVPGLGSAGEASFLS---QCMKYEVDWNQSTLDCVDP--------LSSLAANRSHL-PLSPCEH------------GWVYDTP--GSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLV---VGYIADRFGRKLCLLVTTLVTSLSGVLTAVAPDYTSMLLFRLLQGMVSKGSWVS-GYTLITEFVGSGYRRTTAILYQVAFTVGLVGLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKNRKVPPADLKMMCLEEDASERRSP------SFADLFRTPSLRKHTLILMYLWFSCAVLYQGLIMHVGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVAGAACLLMIFIPHE------LHWLNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLSAGAVTL-LLPETKGVALPETIEEAENLGRRKSK 538
BLAST of slc22a-2 vs. Ensembl Mouse
Match: Slc22a2 (solute carrier family 22 (organic cation transporter), member 2 [Source:MGI Symbol;Acc:MGI:1335072]) HSP 1 Score: 122.865 bits (307), Expect = 4.959e-29 Identity = 120/524 (22.90%), Postives = 234/524 (44.66%), Query Frame = 2
Query: 188 EHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRA----FYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKIN---------KCTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKK--SVSAL-SGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQ 1711
E LN + G G +SF++ +Y V++ T +P +SS N ++L C++ W ++ ++++ E NLVC + ++ L+ FF+G + L+D G++ L+V+I ++ I + +S LV F+ G+ + Y + E + + + + ++ G + +A AY +WR + + + ++LYFW +PE+PRWL+ + +A K + IAK N T +++ K P F +L++ + LIL + + S Y G + A +NI++ F LVE P + + +++GR+ +VS + +G + + +P D L+ WLK+ +A ++G + A+ + ++ EL PT RN A+ + +G I P + L + P ++++++ L+ LV +PET +P+TIE A + ++++ K +Q
Sbjct: 68 EELNYTVPGLGSAGEVSFLS---QCMRYEVDWNQSTLDCVDP--------LSSLAANRSHL-PLSPCEH------------GWVYDTP--GSSIVTEFNLVCAHSWMLDLFQSLVNVGFFIG---AVGIGYLADRFGRKFCLLVTILINAISGVLMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRTVGICYQIAFTVGLLILAGVAYALPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKNAKAMKIIKHIAKKNGKSVPVSLQSLTADEDTGMKLNP------SFLDLVRTPQIRKHTLILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFIIILTIDRIGRRYPWAVSNMVAGAACLASVFIP----DDLQ-----WLKITVACLGRMGITIAYEMVCLVNAELYPTYIRNLAVLVCSSMCDIGGIVTPFLVYRLTDIWLEFPLVVFAVVGLVAGGLV-LLLPETKGKALPETIEDAEKMQRPRKKKEKRIYLQ 546
BLAST of slc22a-2 vs. UniProt/SwissProt
Match: sp|Q9Z0E8|S22A5_MOUSE (Solute carrier family 22 member 5 OS=Mus musculus OX=10090 GN=Slc22a5 PE=1 SV=1) HSP 1 Score: 150.984 bits (380), Expect = 1.214e-37 Identity = 147/560 (26.25%), Postives = 246/560 (43.93%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVK---NISSTIRN-STNLISKDQCQ-------YRLSVNDSWNKC-------------------DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCK-SVYVSLAYTTLIEIIPVS-HIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKIN-----KCTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGW-AFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMI-----HSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLG 1729
DY+ + A +G G F + F LS + + F P+ CLV N+SS RN S L +KD Q YRL+ ++++ D W ++K +T++ E +LVC + L + FFVG L SF LSD G++ +L +++ + T + Q+ S VL + G+ + S YV+ A+ EI+ S I A Y+FG+M + LFAY R WR + + + + +WF+PE+PRWL+ R EA + AKIN + E + ++L++ + I I++ W S Y G + D +I++ F++ VE+P L+ ++ L R+ S+SA LG L+ M + ++ +L L M K G +SA+ + + T EL PT RN + + LGSI +P + L + G + + +L + F PE+ +P+P TI+Q L + ++W++ + +K G
Sbjct: 3 DYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLSSAWRNHSIPLETKDGRQVPQKCRRYRLATIANFSELGLEPGRDVDLEQLEQESCLDGWEYDKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGFSFLQVFSVNFEMFTVLFVLVGMGQISNYVA-AFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSELQDLNSTKPQLHHIYDLIRTRN-IRVITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVPSELF------YLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTL-------FFPESFGVPLPDTIDQM--LRVKGIKQWQIQSQTRMQKDG 545
BLAST of slc22a-2 vs. UniProt/SwissProt
Match: sp|O70594|S22A5_RAT (Solute carrier family 22 member 5 OS=Rattus norvegicus OX=10116 GN=Slc22a5 PE=1 SV=1) HSP 1 Score: 147.517 bits (371), Expect = 1.866e-36 Identity = 143/559 (25.58%), Postives = 241/559 (43.11%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVK---NISSTIRN-STNLISKDQCQ-------YRLSVNDSW-------------------NKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCK-SVYVSLAYTTLIEIIPVS-HIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKIN-----KCTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMI-----HSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLG 1729
DY+ + A +G G F + F LS + + F P+ CLV N+SS RN S L +KD Q YRL+ ++ N D W + K +T++ E +LVC + L + FFVG L SF LSD G++ +L +++ + T + Q+ S VL + G+ + S YV+ A+ EI+ S I A Y+FG+M + LFAY R WR + + + + +WF+PE+PRWL+ R EA + AK N + E + + ++L++ + + ++ S Y G + D +I++ F++ VE+P L+ ++ L R+ S+SA LG L+ + + ++ +L L M K G +SA+ + + T EL PT RN + + LGSI +P + L + G + + +L + F PE+ P+P TI+Q L + ++W++ + +K G
Sbjct: 3 DYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLSSAWRNHSIPLETKDGRQVPQSCRRYRLATIANFSALGLEPGRDVDLEQLEQENCLDGWEYNKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGFSFLQLFSVNFEMFTVLFVLVGMGQISNYVA-AFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRVKEAEVIIRKAAKFNGIVAPSTIFDPSELQDLNSKKPQSHHIYDLVRTRNIRIITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQHLPRRYSISAALFLGGSVLLFIQLVPSELF------YLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTL-------FFPESFGAPLPDTIDQM--LRVKGIKQWQIQSQTRTQKDG 545
BLAST of slc22a-2 vs. UniProt/SwissProt
Match: sp|O76082|S22A5_HUMAN (Solute carrier family 22 member 5 OS=Homo sapiens OX=9606 GN=SLC22A5 PE=1 SV=1) HSP 1 Score: 146.362 bits (368), Expect = 4.192e-36 Identity = 153/577 (26.52%), Postives = 253/577 (43.85%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLT--FALYEPKFSCLV---KNISSTIRNST-NLISKD------QCQ-YRLSVNDSWNKC-------------------DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCK-SVYVSLAYTTLIEIIPVS-HIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTL-----NKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGW-AFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMI-----HSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSL--LIHKEQEWKMDMIQQAEKLGMVHRPSKQLDTEF 1768
DY+ + A +G G F + F LS + F GL+ F + P+ C V N+SS RN T L +D C+ YRL+ +++ D W F + +T++ E NLVC+ + L + FFVG L SF LSD G++ +L V++ + T + Q+ S +VL + G+ + S YV+ A+ EI+ S I + Y+FGYM + LFAY R WR + + + + V +WF+PE+PRWL+ R EA + AK N + + E +Q + +LL+ I I++ W S Y G + D +IF+ F+ +VE+P L+ ++ L R+ S++ LG L+ M + D +L L M K G ++A+ + + T EL PT RN + + LGSI +P + L + G + + +L + F+PE+ P+P TI+Q + + + H++ M++ ++ RP+ T F
Sbjct: 3 DYDEVTAFLGEWGPFQRLIFFLLSASIIPN--GFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVA-AFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWN-IRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLY------YLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTL-------FLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQE-----RPTILKSTAF 557
BLAST of slc22a-2 vs. UniProt/SwissProt
Match: sp|Q9Y226|S22AD_HUMAN (Solute carrier family 22 member 13 OS=Homo sapiens OX=9606 GN=SLC22A13 PE=2 SV=2) HSP 1 Score: 142.895 bits (359), Expect = 5.443e-35 Identity = 127/453 (28.04%), Postives = 210/453 (46.36%), Query Frame = 2
Query: 419 NKCDQ-WTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQ--MVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVS----HIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQ-VTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRK-KSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPS 1747
CD W + + + +L NE NLVCDR ++ + F G L + F L D IG++ ++ + L T+I + + S++++ L + + V + ++ T L E + S + LA NF S G M +A AY FR+WR + I + YFW +PE+ RWL+ R +EA + + A +N+ L+ E N+ P + +G +L +H + LI+ + S Y G + + ++++T + G VE+P S M + GRK + L G++C+II+ FI AD P + LA+ K+ ++A+ I + + EL PT R T M LV I +G I P++ +LL Y A +L L I L+ +PETH + T+ Q + L H + ++ E G P
Sbjct: 107 QPCDMGWEYPENRL-PSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNV--TLLTEWVGPSWRTQAVVLAQCNF----SLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIII-FIPAD------LPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLV--ILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTL-QDLELGPHPRSPKSVPSEKETEAKGRTSSPG 542
BLAST of slc22a-2 vs. UniProt/SwissProt
Match: sp|Q9VCA2|ORCT_DROME (Organic cation transporter protein OS=Drosophila melanogaster OX=7227 GN=Orct PE=1 SV=1) HSP 1 Score: 133.65 bits (335), Expect = 8.121e-32 Identity = 124/528 (23.48%), Postives = 222/528 (42.05%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLT--FALYEPKFSCLVKNISSTIRN------STNLISKDQCQY----------RLSVNDSWNK---CDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKW------------KPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQA 1660
M Y+ + +G G + + L + V F L F L +P F C + + +I + + ++C Y S+ S N+ C + +++ N+ + E NLVC R+ + F +G L S F +SD +G++ S+ L I + V+ + + + + G S +AY +E++ S+ A +S G+M A FAY WR + I + + ++ Y+W +PE+ RWL++ R++EAF + AK NK + E + + Q ++LL++ + + L++ F + S Y G + + N + + G VE+P L N+ GR+ + + I L+ F+ +D WL V AM KL +S++ I + E PT RN + + +G I AP + +L + + P ++ L L +L +PET + P+P+TIE
Sbjct: 1 MGYDDVITHLGEFGPYQKRIYYLLCLPAI--VCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHLWNLSYPENERCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSD------MNWLIVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLK-LLGEIWRPLPLIICGALSLTAGLLS-LLLPETLNKPMPETIEDG 518
BLAST of slc22a-2 vs. TrEMBL
Match: A0A0H3YF32 (Slc22a-2 OS=Schmidtea mediterranea OX=79327 GN=slc22a-2 PE=2 SV=1) HSP 1 Score: 1067.37 bits (2759), Expect = 0.000e+0 Identity = 535/535 (100.00%), Postives = 535/535 (100.00%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPSKQLDTEFDKFLL 1783
MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFLLYSLLLLITVVLVFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPSKQLDTEFDKFLL
Sbjct: 1 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFLLYSLLLLITVVLVFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPSKQLDTEFDKFLL 535
BLAST of slc22a-2 vs. TrEMBL
Match: A0A1I8IPY4 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 215.698 bits (548), Expect = 1.424e-56 Identity = 150/540 (27.78%), Postives = 262/540 (48.52%), Query Frame = 2
Query: 125 IIFADLYTIHRHLVPFTGMDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWN------KCDQWTFEK-RFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLI---EIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPI---QQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVL-LQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMD 1702
I+ ADL + H GM+YE + +IGG G F+ LS T+FK V++ + + L+E KF C +N S + + + + C+ V D N C ++ ++ + +++ E NLVCDR Y + + FF+GC F L D IG++ +LIV I TI Q+ F+ G +VY Y L+ E+ H + +W + GYM + YIF+ W +I + S + + Y++ F VPE+PRWL+L R EA + IAK N + + +K K + ++ TG +L+ + M + +++ F F+ Y G +TD TF + NI + + G VE+P+ + + +++ GRK + ++ L CLI +P + + ++ +K +AM K ++ + I D+ E+ PT+ RN + L L +I AP+I+++ + + G L + I L +PET LP+P+T+ + L+ +E++W ++
Sbjct: 51 ILQADLKCLQFHPFEQAGMEYESVLKEIGGFGRVQKAIFLALSFTSFKAVLDLELMVLTLHESKFRCAQQNSSDYVAQNYS----EHCRISRLVGDDTNFTLINETCTKFDYQHGDVISKSMVEEYNLVCDRKHYATGMMSVFFLGCALGMLFGTLGDKIGRKKILIVCGVTDLITTILPAFMPTAETQIFARFLKGFPAAVY----YQGLLIMEEMTEEKHRAVLGNLYWLFWCVGYMFSGVVVYIFKEWDKIQLFSTVFCLNYIVIFIVVPESPRWLVLKGRVEEAVDVLKRIAKWNGIKW-EHKVSKVKALDVEEEPTGNILDLVTYPEMRMKSIVIFFNLAMFAMCYFGLSTDTTFITTNIVLNVLLNGAVEIPSSFIGWLGSDRYGRKYTTVIITVLSGFCLIAVPIVPTGGVYNI----VKAVVAMVGKCLLTTGYCIADVWAAEIFPTSVRNNGLFLATTLAMLSNIVAPVINTLSDVATFLPG---LIFGITSIVSALSLLLLPETKGLPLPETVPSSEGLVRGRERQWAIE 574
BLAST of slc22a-2 vs. TrEMBL
Match: A0A267GXD4 (MFS domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig033092g1 PE=4 SV=1) HSP 1 Score: 209.534 bits (532), Expect = 2.791e-56 Identity = 142/519 (27.36%), Postives = 252/519 (48.55%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWN------KCDQWTFEK-RFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPI---QQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVL-LQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMD 1702
M+YE + +IGG G F+ LS T+FK V++ + + L+E KF C +N S + + + + C+ V D N C ++ ++ + +++ E NLVCDR Y + + FF+GC F L D IG++ +LIV I TI Q+ F+ G +VY + E+ H + +W + GYM + YIF+ W +I + S + + Y++ F VPE+PRWL+L R EA + IAK N + + +K K + ++ TG +L+ + M + +++ F F+ Y G +TD TF + NI + + G VE+P+ + + +++ GRK + ++ L CLI +P + + ++ +K +AM K ++ + I D+ E+ PT+ RN + L L +I AP+I+++ + + G L + I L +PET LP+P+T+ + L+ +E++W ++
Sbjct: 1 MEYESVLKEIGGFGRVQKAIFLALSFTSFKAVLDLELMVLTLHESKFRCAQQNSSDYVAQNYS----EHCRISRLVGDDTNFTLINETCTKFDYQHGDVISKSMVEEYNLVCDRKHYATGMMSVFFLGCALGMLFGTLGDKIGRKKILIVCGVTDLITTILPAYMPTAETQIFARFLKGFPAAVYYQ-GLLIMEEMTEEKHRAVLGNLYWLFWCVGYMFSGVVVYIFKEWDKIQLFSTVFCLNYIVIFIVVPESPRWLVLKGRVEEAVDVLKRIAKWNGIKW-EHKVSKVKALDVEEEPTGNILDLVTYPEMRMKSIVIFFNLAMFAMCYFGLSTDTTFITTNIVLNVLLNGAVEIPSSFIGWLGSDRYGRKYTTVIITVLSGFCLIAVPIVPTGGVYNI----VKAVVAMVGKCLLTTGYCIADVWAAEIFPTSVRNNGLFLATTLAMLSNIVAPVINTLSDVATFLPG---LIFGITSIVSALSLLLLPETKGLPLPETVPSSEGLVRGRERQWAIE 506
BLAST of slc22a-2 vs. TrEMBL
Match: A0A1I8FU44 (MFS domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig008926g2 PE=4 SV=1) HSP 1 Score: 207.994 bits (528), Expect = 1.392e-55 Identity = 151/537 (28.12%), Postives = 268/537 (49.91%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISS----------TIRNST---NLISKDQCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLI---EIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWL---KVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIH--SVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKL 1726
M+YE + +IGG G + F++LS+T+ K V++ Q L L+ F C +N S TI S+ N S D Y N + C ++ FE F+R T++ + LVC R Y ++ + +F G F+ L D IG+R +L+V + + T+ + + + Q+ F+ G+ VY Y L+ E+ H + +W L+ GY +L AY+ + WR I ++SL S Y+L ++ VPE+PRWL+L R EA + +A+ N +F+K + TG+ L + M + LI+ F +S AY G D TF ++++I T V G++E+P L+ ++ ++GR+ A+S + + +I +PFI + Q +L KV +A+ K ++A+ DI E PT+ RN + L + G S+ +P+I+ S + ++ A F +++ +++V+ ++PET +P+P T+E A + E W+ + ++ ++
Sbjct: 1 MEYEKILTQIGGFGRAQLMVFLSLSMTSVKAVLDLQLLALMLHVSPFRCAQQNSSGYEPQGFDSHCTISRSSEAGNASSADPSLYSAG-NMTEEACTEFEFENDFIRLTMVKDFQLVCARDIYPTILMSVYFFGDACGMLFATLGDRIGRRTILLVCGCVDIVTTVLPVFTPTVEWQIGARFLKGLASPVY----YQGLLLVEELTAAKHRAMLGNLYWLLWCIGYSLCSLIAYLGQEWRIIQLISLAFSSSYILVYFLVPESPRWLLLKGRTKEAGRVFEKMARWNGIRWRTNKFDKIVIEETPTGRTLELFTYPIMRRKTLIIVFVMLVYSLAYYGLTIDTTFIIDDVYINTAVSGVLEIPAYLLAWQVSERIGRRTPTVAMSIVAGVAIIAVPFIPQE------QQYLFAIKVAMALIGKCLLTAAYSAMDIYGAENFPTSLRNNGVFLSAVVAGFLSVISPVINYLSTVAEWLPAVVFGGLTIVSVLSVL----WLPETKDMPLPDTVEDAEKFVRGNELNWRAEHEERERQV 522
BLAST of slc22a-2 vs. TrEMBL
Match: A0A267FBR0 (MFS domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig009851g1 PE=4 SV=1) HSP 1 Score: 204.527 bits (519), Expect = 1.525e-54 Identity = 142/520 (27.31%), Postives = 253/520 (48.65%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWN------KCDQWTFEK-RFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPI---QQVTGKFWNLLKHKTMIYRFLILNFAGWA-FSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVL-LQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMD 1702
M+YE + +IGG G F+ LS T+FK V++ + + L+E KF C +N S + + + + C V D N C ++ ++ + +++ E +LVCDR Y + + FF+GC F L D IG++ +LIV I TI Q+ F+ G +VY + E+ H + +W + GYM + YIF+ W +I + S + + Y++ F VPE+PRWL+L R EA + IAK N + + +K K + ++ TG +L+ + M + +++ F+ A F+ Y G +TD TF + NI + + G VE+P+ + + +++ GRK + ++ L CLI +P + + ++ +K +AM K ++ + I D+ E+ PT+ RN + L L +I AP+I+++ + + G L + I L +PET LP+P+T+ + L+ +E++W ++
Sbjct: 1 MEYESVLKEIGGFGRVQKAIFLALSFTSFKAVLDLELMVLTLHESKFRCAQQNSSDYVAQNYS----EHCSISRLVGDDTNFTLINETCTKFDYQHGDVISKSMVEEYDLVCDRKHYATGMMSVFFLGCALGMLFGTLGDKIGRKKILIVCGVTDLITTILPAFMPTAETQIFARFLKGFPAAVYYQ-GLLIMEEMTEEKHRAVLGNLYWLFWCVGYMFSGVVVYIFKEWDKIQLFSTVFCLNYIVIFIVVPESPRWLVLKGRVEEAVDVLKRIAKWNGIKW-EHKVSKVKALDVEEEPTGNILDLVTYPEMRMKSIVI-FSNLAMFAMCYFGLSTDTTFITTNIVLNVLLNGAVEIPSSFIGWLGSDRYGRKYTTVIITVLSGFCLIAVPIVPTGGVYNI----VKAVVAMVGKCLLTTGYCIADVWAAEIFPTSVRNNGLFLATTLAMLSNIVAPVINTLSDVATFLPG---LIFGITSIVSALSLLLLPETKGLPLPETVPSSEGLVRGRERQWAIE 506
BLAST of slc22a-2 vs. Ensembl Cavefish
Match: si:dkey-119m7.4 (solute carrier family 22 member 13-like [Source:NCBI gene;Acc:103028301]) HSP 1 Score: 148.288 bits (373), Expect = 6.312e-38 Identity = 130/506 (25.69%), Postives = 231/506 (45.65%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCL-----VKNISSTIRNS-TNLISKDQCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTL--NKEEF--NKWKPIQQVTGKFW--NLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQ 1657
M+++ + A+IGG G F I ++ + + F P C N + T+ S + LS + + D W F K +T++ E +LVCD A + + + G L + F +L+D G+R++++V + L + +G + + ++L FV G S + A+ E H LA + GY+ +A AY+ R WR++ + ++ Y W +P++ RWLM N ++ EA + A INK L N EF N K Q++ K +L++ M + LIL + + Y G + +++ NI++T + GLVE+P ++ N+ R +S L+ G+ CL+ + FI + P ++ LAM K G +++ I + + E+ PT R + + + G + AP+I+ +L + P +++ L L+ +L +PET H P+P TIE
Sbjct: 1 MNFDEVLARIGGFGRFQKILYVWICLPQIFLAFHMLVSVFTGAVPPHLCRDTKTHTHNFNFTLSQSASEACGSTHTNSSLSTHTTTACRDGWEFSKDVFLSTVVTEFDLVCDSATLNNIGSSIYMFGLLVGAVVFGVLADRYGRRIIILVGLALQAMFGVGAAFAPNFFIYVLLRFVVGTTVSGIIMNAFVLGTEWTGPKHRMLAGIITDYFFGVGYILLAGVAYLIRDWRKLQLAISAPGFIFIFYIWVLPKSARWLMANGKQEEAMDLICKAALINKKPLKGNDMEFQLNNCKVEQKLQRKHTVVDLVRTPQMRKQSLILFYLWFVNVLVYYGLSLNVSDFGMNIYLTQLIFGLVEMPARTITLFTLNRSRRISQLSFLAVGGLACLLTI-FIPQN------LPVVRTILAMLGKFGITASLSIVYVYSAEVFPTVVRQNGIGMGSMCARAGGVIAPIIY-LLRRISPHAPMVVFGLCPLVGALLTI-LLPETAHKPLPDTIED 497
BLAST of slc22a-2 vs. Ensembl Cavefish
Match: si:dkey-166k12.1 (organic cation transporter protein-like [Source:NCBI gene;Acc:103028750]) HSP 1 Score: 140.969 bits (354), Expect = 2.506e-35 Identity = 129/522 (24.71%), Postives = 228/522 (43.68%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISK---DQCQYRLSVNDSW-NKCDQ-WTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGK----FWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHK-EQEWKMDMIQ 1711
M++E L A GG G F ++ + + + F P C S + NS+ IS D C + N S + C+ W + + +T + E +LVC RA + + + +G L + F ++D G+R L++S+ L T+ + + ++L F+ G S + A+ E LA + GYM +A AY+ R WR++ + ++ Y W +P + RWL++N R+ EA + A +N + W + G+ +L++ M R LIL + + Y G + ++ +++ T F+ GLVE+P L ++ R+ +SA +G ++M + AD+ P ++ LAM K G ++++ I I + EL PT R T + + + +G + APMI+ +L Q P +L + + +PET + P+P TI+ A K +Q + D IQ
Sbjct: 1 MNFEQLLAAAGGFGRFQKTLYVWICLPQVQLAFHMMVSVFTGATPPHRCR----SLRLANSSAGISAGHADACSAGSAENRSARSACESGWVYSQDVFESTTVTEWDLVCGRASLNSICSSIYMLGLLVGAVVFGAMADRYGRRFALLLSLALQTVFGVAAAFAPNFLVYVILRFLIGTTISGIIINAFVLGTEWTSTKRRMLAGIFTDYFFGLGYMLLAGIAYLIRDWRKLQLAISAPGFLFIFYIWVLPHSARWLLVNDRKEEAIVLLRKAAMVNGRSFPTTVQLDW--CDETEGRSQHSVADLVRTPEMRKRALILYYIWFVNVLVYYGLSLGVSGLGTDLYFTQFMFGLVEVPARSLV-LLVLPCSRRIPLSAFLFIGGGACLLMLAVPADN------PNIQTALAMTGKFGITASFAIIYIYSAELFPTVLRQTGIGVSSMFARMGGVLAPMIN-LLGQHNPVVP-VLIFGSTPLLGAALALALPETANKPLPDTIQDAERFSNEKYDQAFPADTIQ 507
BLAST of slc22a-2 vs. Ensembl Cavefish
Match: si:dkey-166k12.1 (organic cation transporter protein-like [Source:NCBI gene;Acc:103028750]) HSP 1 Score: 136.732 bits (343), Expect = 7.308e-34 Identity = 129/535 (24.11%), Postives = 228/535 (42.62%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISST-------------IRNSTNLISK---DQCQYRLSVNDSW-NKCDQ-WTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGK----FWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHK-EQEWKMDMIQ 1711
M++E L A GG G F ++ + + + F P C S + NS+ IS D C + N S + C+ W + + +T + E +LVC RA + + + +G L + F ++D G+R L++S+ L T+ + + ++L F+ G S + A+ E LA + GYM +A AY+ R WR++ + ++ Y W +P + RWL++N R+ EA + A +N + W + G+ +L++ M R LIL + + Y G + ++ +++ T F+ GLVE+P L ++ R+ +SA +G ++M + AD+ P ++ LAM K G ++++ I I + EL PT R T + + + +G + APMI+ +L Q P +L + + +PET + P+P TI+ A K +Q + D IQ
Sbjct: 1 MNFEQLLAAAGGFGRFQKTLYVWICLPQVQLAFHMMVSVFTGATPPHRCRSARPGSPHLNQSHAVVLELRLANSSAGISAGHADACSAGSAENRSARSACESGWVYSQDVFESTTVTEWDLVCGRASLNSICSSIYMLGLLVGAVVFGAMADRYGRRFALLLSLALQTVFGVAAAFAPNFLVYVILRFLIGTTISGIIINAFVLGTEWTSTKRRMLAGIFTDYFFGLGYMLLAGIAYLIRDWRKLQLAISAPGFLFIFYIWVLPHSARWLLVNDRKEEAIVLLRKAAMVNGRSFPTTVQLDW--CDETEGRSQHSVADLVRTPEMRKRALILYYIWFVNVLVYYGLSLGVSGLGTDLYFTQFMFGLVEVPARSLV-LLVLPCSRRIPLSAFLFIGGGACLLMLAVPADN------PNIQTALAMTGKFGITASFAIIYIYSAELFPTVLRQTGIGVSSMFARMGGVLAPMIN-LLGQHNPVVP-VLIFGSTPLLGAALALALPETANKPLPDTIQDAERFSNEKYDQAFPADTIQ 524
BLAST of slc22a-2 vs. Ensembl Cavefish
Match: ENSAMXT00000010878.2 (pep primary_assembly:Astyanax_mexicanus-2.0:14:29265439:29284025:-1 gene:ENSAMXG00000010589.2 transcript:ENSAMXT00000010878.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 132.494 bits (332), Expect = 2.827e-32 Identity = 130/470 (27.66%), Postives = 217/470 (46.17%), Query Frame = 2
Query: 419 NKC-DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFS-ILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQL-VLSFVSGVCK-SVYVS---LAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKC-------TLNKEEFNKWKPIQ-QVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKS--VSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAP-MIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQ--------AVSLLIHKEQEWKMDMIQ--------QAEKL 1726
KC D WT+ K ++T++ E +LVCD + + + +F+G L FS +SD G++ +L ++ + TI T Q+ + W+ +L F+ G+ + S YV+ L L + V + L F ++FGYM + L AY+ R+WR + + + + Y+ +WF+PE+PRWL+ R EA + A+ N ++EE KP + + +L++ + LIL S Y G + + + + ++ F+ +E+P S + L RK S VS L G G++ I + + D P L V L M K G + + T EL PT RNTA+ + +GS AP IH + Y P++L L + + + F+PET P+P+TI+Q I+KE++ +++ I Q EKL
Sbjct: 127 EKCTDGWTYSKDVYQSTIVTEFDLVCDDEWKQPFTSSIYFIGVLCGSFFSGQISDRFGRKPVLFATMMVQTIFTFIQVFAPS-WEVFSILFFIVGLGQISNYVAAFVLGTELLSGGVRVFYSSLGVCLF---FAFGYMMLPLIAYLIRNWRMLLVALSVPGLIYIPLWWFIPESPRWLISQGRVEEAEAIVKNAARKNGVLPPDIIFKKSEEEEKNTKPQKTKPENNILDLMRTSNIRRTTLILFLVWLTLSMGYFGLSLNTSRLHGDSYVNCFISAALEVPAYITSWLSLRYLPRKLSCPVSMLLGGGVLYFIQL--VPPD------LPALSVALEMAGKFGMAIGTALMFAYTGELYPTVLRNTAVGSCAMVSRVGSAVAPYFIHLSVYHKYL--PYILLGTLCIFSSLTTL-FLPETFRRPLPETIDQMQKRERINCPCFSINKEKDPQLNTISNTSVPQILQEEKL 581
BLAST of slc22a-2 vs. Ensembl Cavefish
Match: slc22a4 (solute carrier family 22 member 4-like [Source:NCBI gene;Acc:103026746]) HSP 1 Score: 130.954 bits (328), Expect = 8.913e-32 Identity = 141/535 (26.36%), Postives = 240/535 (44.86%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGL--TFALYEPKFSCLVK---NISSTIRNST-NLISKDQCQYRLS----------------------VNDS---WNKC-DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQ--QLVLSFVSGVCKSVYVSLAYTTLIEII-PVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNK-----EEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRK--KSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQ 1657
DY+ + + +G G F FM L+I+ F GL F P CL+ NIS R + LI++D R S VN S KC D W + K ++T++ E +LVCD + L + +F+G L +F LSD G+R +L + + T+ QM S W+ + FV S YV + + EI+ P + + + + G M + L AY R WR + +++ +T + Y+ +WF+PE+PRWL+ R EA + A+ NK + + E + I++ ++L++ + +I + + +Y G + + + ++ F+ +VELP ++ ++ R+ +S + L G GII + + + D P L V L M K G ++A+ + +T+EL PT RN AM + ++ +GSI +P I L +Y P+LL ++ +L +PET +P+TI Q
Sbjct: 3 DYDDITSFLGTWGRFQLTVFMALAISILPN--GFVGLYIVFVGDTPTHQCLIPEEYNISEIWREAAIPLITQDGILKRSSCSRYNIDTLRNYSLMGYIPDVDVNMSSIELEKCLDGWNYSKEIYQSTIVTEWDLVCDNEYKVPLCSSIYFLGVLMGTFISGQLSDKYGRRPVLFAMMAMQTLTIFIQMFSPS-WEVFTAIYFFVGFSGFSNYV-VGFVLGSEILSPATRVVFCSLGVFMGSGIGQMFLPLAAYFARWWRLLVLINALTGVLYIPLWWFIPESPRWLLSQGRIAEAEAILRQAAQKNKISAPEVIFIPSEIEESAAIRKKKYSILDILRNGNAVTICIICSLLWIVITMSYYGLILNTSNLHGDPYLNYFISAVVELPAFFIAMLLLKYCSRRFCQSSTLLLGGGII--LFVQLVPED------LPELAVFLEMVGKFGITAAFCVVYAVTSELFPTVVRNMAMGICSMSARIGSIISPFII-YLGSYYKMLPYLLLGAWAVVASLLCL-LLPETSGKVLPETISQ 523
BLAST of slc22a-2 vs. Ensembl Sea Lamprey
Match: oct2 (organic cation transporter 2 [Source:ZFIN;Acc:ZDB-GENE-080204-92]) HSP 1 Score: 143.28 bits (360), Expect = 1.099e-36 Identity = 132/581 (22.72%), Postives = 241/581 (41.48%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLV----KNISSTIRNSTNLISKDQCQYRLSVNDSWN---------------------------------------KCDQ-WTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGKFWNL----LKHKTMIYRFLILNFAGW-AFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGL-GIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPSKQLDTEFD 1771
D++ L IG G F + F L + + ++ + F P+ C + + SS S +++ + S+ D WN CD W F+ TL++E +LVC+ A+ +L VG L + +SD G+R L+VSI + TI + + + + + G+ + + T E + + +SFG + ++ AY R+WR + + + ++ Y+W +PE+PRWL+ R+ +AF + IA +N L+ ++ + + K N L I ++ ++ W Y G A +++++ + GL E+P + + +++GR+ + GL G+ CL A +L WL + L +LG + A+ + ++ NEL PT RN AMS G+G I AP + L + P +++ L +I ++ +PET+ LP+P+T E A + I K Q+ K M++ + P + D++ D
Sbjct: 3 DFDSLLQGIGEFGPFQHRVFAMLCLPCTLFAFQYLNIVFLGQVPEHRCRLPTETRRTSSRCGASLEAAHRNRSRASGSLEDQWNLQCMRVNTTTWSDSNAPCGLAPWGQGDEVPNVSFSGRLIACDHGWEFDTEKTGLTLVSEFDLVCENAWLLDLSQALLNVGLLVGAILMGYVSDRYGRRWSLMVSIVMQTIFGVLVAFAPNYAAFVCMRTLQGIFNMGSWTTVFVTATEFVGSGQRRVVHMVLQMFFSFGVIMLSGIAYYLRTWRYLQLALTLPNVVLFSYYWLLPESPRWLISQNRKEQAFGVLKKIASVNGRELSDNIRKNFEEVTRADEKAGNPSIADLMRSAKIRKYTVVLMIYWFVVGVVYQGLAMSTGNIGDDVYLAFLMGGLAEIPGALMVIALIDRVGRRLPMCVAPGLSGLACL-------ATALVPHDIGWLNITLVTLGRLGLTMAYEMVTLVNNELYPTHLRNMAMSTCSSLSGIGGIVAPFVLYRLYTIWRHLPMVIFGTLAIIGGFVIL-LLPETNGLPLPETTEDAEN--ISKNQKMKQKMLRSRKF--ETKNPLRNEDSQAD 571
BLAST of slc22a-2 vs. Ensembl Sea Lamprey
Match: SLC22A7 (solute carrier family 22 member 7 [Source:HGNC Symbol;Acc:HGNC:10971]) HSP 1 Score: 98.5969 bits (244), Expect = 7.678e-23 Identity = 55/190 (28.95%), Postives = 93/190 (48.95%), Query Frame = 2
Query: 434 WTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCT 1000
W +++R T++ + +LVC+ L T F G + S F LSD G+R L+ S L+ + + + F+ GV S + + +E + H A T+ +S G M++ L AY+ R W+Q+ ++ F +L +WF+PE+PRWL++ R EA + +S A+IN T
Sbjct: 115 WEYDRRQFTETVVTQWDLVCEHKALNHLSLTLFMAGVMLGSLVFGYLSDRYGRRNALLGSYVLNAVTGTAAAWAPSFSSFTAMRFLLGVSLSGIIVNTLSLSVEWLDQGHRTFAGTSGGFAWSTGNMALGLLAYLLRGWQQLQLVVTSPIYFCILTWWFIPESPRWLLVRGRAREAHRNLSLCARINGRT 304
BLAST of slc22a-2 vs. Ensembl Sea Lamprey
Match: si:dkey-190l8.2 (si:dkey-190l8.2 [Source:ZFIN;Acc:ZDB-GENE-030131-9103]) HSP 1 Score: 89.3521 bits (220), Expect = 2.381e-19 Identity = 98/381 (25.72%), Postives = 163/381 (42.78%), Query Frame = 2
Query: 494 DRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLA------ATNFWN------LYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQ---QVTGKFWN------LLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKK-SVSALSGLGIICLIIMPFIEADSLKSVWQPWLK---VCLAMGAKLGFSSAWLIFDIITNELIPTT-------DRNTAMSLVYITVGLGSIFAPMIHSVLL 1537
D FY + TTF VG L S I SD G+R +L+ V+ Q + V++F+ + L T I + L A W +S G M++A A I ++W Q+++ + + + +L FW +PE+PRWL L KR EA + + IN+ + E + W P++ +++ + N +++T+ R LI+++ A S Y G + +I + F+ GL E+P L +M ++GR+ + LS G CL+ +P QP L V LA+ KL + + EL PT R A+ V + +GS+ AP+++ L
Sbjct: 16 DFKFYTQ---TTFMVGLLVGSIAMGIASDRYGRRPVLL------------GCVASQGAAEFVIAFLPNFPTYLLGRLLTGTTASGIMLCSFSLGVEWCGPALRAWPPIILALAFSVGMMALAGVAKISQNWPQLHLATGVPQLMVLLLFWSLPESPRWLFLKKRTTEARNLLRQASIINR----RSEVS-WTPLRLTSKLSTRGANESTLLITFRNRTLRKRLLIMSYICAAVSMTYYGLCLSVGDFGLDIHMAQFLSGLAEIPQLLLPPLM-RRVGRRSLCIVFLSVAGATCLLCLPL----------QPNLANVVVALALLGKLCAQVTACVATLYRIELFPTNVRPRCHGHRQNALGAVAMCGSVGSLLAPLVNRAAL 365
BLAST of slc22a-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007122.1 (pep scaffold:Pmarinus_7.0:GL476962:153150:164773:-1 gene:ENSPMAG00000006444.1 transcript:ENSPMAT00000007122.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 80.4925 bits (197), Expect = 3.623e-17 Identity = 59/253 (23.32%), Postives = 108/253 (42.69%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCG-----LFHYISFMTLSITTFKYVVEFQGLTFAL--------YEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWNKC-DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFP-FSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYV 892
M+++ + KIGG G L+ +I +SI V F G T A + P S ++ + N + +C RL+ W C W +++ +T++ E +LVC R++ + + F +G + P ++D G++ +++VS+ + T +G + + F+ GV S + A+ E + LA + GYM +A AY R WRQ+ + I I ++
Sbjct: 1 MNFDDVLKKIGGFGKFQMILYTWICLPHISIAMHMLVSVFAGATPAHFCRDPPGGHAPVPSATTAPPTAGESAAANGTERPRCGSRLN-ESGWQPCATGWDYDRSVFTSTVVTEWDLVCTRSYLNNVGSSIFMLGLMVGAPVLGTMADKYGRKSVILVSMAIQTAFGLGAAFAPNFVMYALARFMVGVAISGVIMNAFVLATEWTGIGERMLAGIATQQAFGVGYMLLAPVAYFIRDWRQLQLAISIPEILFI 252
BLAST of slc22a-2 vs. Ensembl Sea Lamprey
Match: slc22a6l (solute carrier family 22 member 6, like [Source:NCBI gene;Acc:404609]) HSP 1 Score: 72.0182 bits (175), Expect = 5.399e-14 Identity = 75/304 (24.67%), Postives = 140/304 (46.05%), Query Frame = 2
Query: 794 YSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYF--WFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNK-----WKPIQQVTG--KFW---NLLKHKTMIYRFLILNFAGWAFSFA-YIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVS---ALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQ 1657
Y+ G + + AY R WR ++ I++ FYV + W PE+ RWL++ A + +A IN + K +++ TG +F+ NLL + R L+++ F Y G +T + F+ + G ++ P + ++ + LGR+ + + A++ + CL+ +P A+S + + CLA+ K S ++ + T E+ PT R + + L +G + AP++ + + A P +Y L+ LV+ F+PET + P+P+TIE+
Sbjct: 20 YTTGQLVLVALAYYIRDWR--HLQHSISAAFYVFFLCSWCTPESARWLVMRGHYERALHGLKRVAVINGRKREAAQLTSPLQYLRKELEEDTGPRRFYTMFNLLTIPALRRRTLVMSLVWCDDVFCWYAGFVVIVTRTCAHTFLLQVIYGAIDYPAKVVGLVVLSLLGRRATQAGSLAVASIASFCLLAIP---AESGTA------RTCLAVLGKGALSCSFNCAYLYTGEIFPTVIRQSGLGLCSTMARVGGMLAPLV-IMAGESLPALPLSMYGSASLVAGSLVY-FLPETLNRPLPETIEE 310
BLAST of slc22a-2 vs. Ensembl Yeast
Match: HXT13 (Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication [Source:SGD;Acc:S000000795]) HSP 1 Score: 60.4622 bits (145), Expect = 4.914e-10 Identity = 107/463 (23.11%), Postives = 186/463 (40.17%), Query Frame = 2
Query: 515 LIFTTFFVGC-LFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQ-LVLSFVSGVCKSVYVSLAYTTLIEIIPV----SHIDLAATNFWNLYSFGYMSVALFAYIFR------SWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAK--------------INKCTLNKEEFNK--WKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKL--------GFSSAWL-IFDIITNELIPTTDRNTAMSLV----YITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPSKQLDTEFDKFL 1780
L+ F +GC + F+ L+D++G+RL +++ + + + I Q+ S W Q V + G+ L L EI P + L N GY SV Y R WR L + ++ ++ VPE+PR+L+ +R EA +++ I K IN L + E + WK + V K L ++ FL L + F + G+ + + F T+ V+G V + ++ ++ +K+GR+K + + + C++I I L Q A A + F++ W + I+ E P+ ++ AMS+ ++ L F P I + FY+ F L+ + VF F+PET L ++E+ L + WK + G+ SK ++ KFL
Sbjct: 110 LLVAMFSIGCAIGGLIFARLADTLGRRLAIVIVVLVYMVGAIIQISSNHKWYQYFVGKIIYGLGAGGCSVLCPMLLSEIAPTDLRGGLVSLYQLNMTFGIFLGYCSV----YGTRKYDNTAQWRVPLGLCFLWALIIIIGMLLVPESPRYLIECERHEEARASIAKINKVSPEDPWVLKQADEINAGVLAQRELGEASWKELFSVKTKVLQRLITGILVQTFLQLTGENY---FFFYGTTIFKSVGLTDGFETSIVLGTVNFFSTIIAVMVVDKIGRRKCLLFGAAGMMACMVIFASIGVKCLYPHGQDGPSSKGAGNAMIVFTCFYIFCFATTWAPVAYIVVAESFPSKVKSRAMSISTACNWLWQFLIGFFTPFITGS-IHFYYGYVF---VGCLVAMFLYVFFFLPETIGL----SLEEIQLLYEEGIKPWKSASWVPPSRRGISSEESKTEKKDWKKFL 557
BLAST of slc22a-2 vs. Ensembl Yeast
Match: HXT17 (Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication [Source:SGD;Acc:S000005355]) HSP 1 Score: 60.077 bits (144), Expect = 5.694e-10 Identity = 107/463 (23.11%), Postives = 186/463 (40.17%), Query Frame = 2
Query: 515 LIFTTFFVGC-LFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQ-LVLSFVSGVCKSVYVSLAYTTLIEIIPV----SHIDLAATNFWNLYSFGYMSVALFAYIFR------SWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAK--------------INKCTLNKEEFNK--WKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKL--------GFSSAWL-IFDIITNELIPTTDRNTAMSLV----YITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPSKQLDTEFDKFL 1780
L+ F +GC + F+ L+D++G+RL +++ + + + I Q+ S W Q V + G+ L L EI P + L N GY SV Y R WR L + ++ ++ VPE+PR+L+ +R EA +++ I K IN L + E + WK + V K L ++ FL L + F + G+ + + F T+ V+G V + ++ ++ +K+GR+K + + + C++I I L Q A A + F++ W + I+ E P+ ++ AMS+ ++ L F P I + FY+ F L+ + VF F+PET L ++E+ L + WK + G+ SK ++ KFL
Sbjct: 110 LLVAMFSIGCAIGGLIFARLADTLGRRLAIVIVVLVYMVGAIIQISSNHKWYQYFVGKIIYGLGAGGCSVLCPMLLSEIAPTDLRGGLVSLYQLNMTFGIFLGYCSV----YGTRKYDNTAQWRVPLGLCFLWTLIIIIGMLLVPESPRYLIECERHEEARASIAKINKVSPEDPWVLKQADEINAGVLAQRELGEASWKELFSVKTKVLQRLITGILVQTFLQLTGENY---FFFYGTTIFKSVGLTDGFETSIVLGTVNFFSTIIAVMVVDKIGRRKCLLFGAAGMMACMVIFASIGVKCLYPHGQDGPSSKGAGNAMIVFTCFYIFCFATTWAPVAYIVVAESFPSKVKSRAMSISTACNWLWQFLIGFFTPFITGS-IHFYYGYVF---VGCLVAMFLYVFFFLPETIGL----SLEEIQLLYEEGIKPWKSASWVPPSRRGIPSEESKTEKKDWKKFL 557
BLAST of slc22a-2 vs. Ensembl Yeast
Match: HXT16 (Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose [Source:SGD;Acc:S000003919]) HSP 1 Score: 56.6102 bits (135), Expect = 8.006e-9 Identity = 83/358 (23.18%), Postives = 146/358 (40.78%), Query Frame = 2
Query: 515 LIFTTFFVGC-LFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQ-LVLSFVSGVCKSVYVSLAYTTLIEIIPV----SHIDLAATNFWNLYSFGYMSVALFAYIFR------SWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAK--------------INKCTLNKEEFNK--WKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKL--------GFSSAWL-IFDIITNELIPTTDRNTAMSL 1477
L+ F VGC + F+ L+D++G+RL +++ + + + I Q+ S W Q V + G+ L L EI P + L N GY SV Y R WR L + ++ ++ VPE+PR+L+ +R EA +++ I K IN L + E + WK + V K L ++ FL L + F + G+ + + F T+ V+G V + ++ ++ +K+GR+K + + + C++I I L Q A A + F++ W + I+ E P+ ++ AMS+
Sbjct: 113 LLVAMFSVGCSIGGVAFARLADTLGRRLAIVIVVLVYMVGAIIQISSNHKWYQYFVGKIIYGLGAGGCSVLCPMLLSEIAPTDLRGGLVSLYQLNMTFGIFLGYCSV----YGTRKYSNTAQWRIPVGLCFLWALIIIVGMLLVPESPRYLIECERHEEACVSIAKIDKVSPEDPWVLKQADEINAGVLAQRELGEASWKELFSVKTKVLQRLITGILVQTFLQLTGENY---FFFYGTTIFKSVGLTDGFETSIVLGTVNFFSTIIAVMVVDKIGRRKCLLFGAASMMACMVIFASIGVKCLYPHGQDGPSSKGAGNAMIVFTCFYIFCFATTWAPVAYIVVAESFPSKVKSKAMSI 463
BLAST of slc22a-2 vs. Ensembl Yeast
Match: HXT15 (Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose [Source:SGD;Acc:S000002404]) HSP 1 Score: 56.225 bits (134), Expect = 8.654e-9 Identity = 83/358 (23.18%), Postives = 146/358 (40.78%), Query Frame = 2
Query: 515 LIFTTFFVGC-LFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQ-LVLSFVSGVCKSVYVSLAYTTLIEIIPV----SHIDLAATNFWNLYSFGYMSVALFAYIFR------SWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAK--------------INKCTLNKEEFNK--WKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKL--------GFSSAWL-IFDIITNELIPTTDRNTAMSL 1477
L+ F VGC + F+ L+D++G+RL +++ + + + I Q+ S W Q V + G+ L L EI P + L N GY SV Y R WR L + ++ ++ VPE+PR+L+ +R EA +++ I K IN L + E + WK + V K L ++ FL L + F + G+ + + F T+ V+G V + ++ ++ +K+GR+K + + + C++I I L Q A A + F++ W + I+ E P+ ++ AMS+
Sbjct: 113 LLVAMFSVGCSIGGVAFARLADTLGRRLAIVIVVLVYMVGAIIQISSNHKWYQYFVGKIIYGLGAGGCSVLCPMLLSEIAPTDLRGGLVSLYQLNMTFGIFLGYCSV----YGTRKYSNTAQWRIPVGLCFLWALIIIVGMLLVPESPRYLIECERHEEACVSIAKINKVSPEDPWVLKQADEINAGVLAQRELGEASWKELFSVKTKVLQRLITGILVQTFLQLTGENY---FFFYGTTIFKSVGLTDGFETSIVLGTVNFFSTIIAVMVVDKIGRRKCLLFGAASMMACMVIFASIGVKCLYPHGQDGPSSKGAGNAMIVFTCFYIFCFATTWAPVAYIVVAESFPSKVKSKAMSI 463
BLAST of slc22a-2 vs. Ensembl Yeast
Match: HXT2 (High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose [Source:SGD;Acc:S000004613]) HSP 1 Score: 51.2174 bits (121), Expect = 3.778e-7 Identity = 74/336 (22.02%), Postives = 132/336 (39.29%), Query Frame = 2
Query: 428 DQWTFEKRFMRNTLINELNLVCDRAFY-----RELIFTTFFVGCLFS-FPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQ-LVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNL---------YSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNK-------EEFNKWKPIQQVTGK--FWNLLKHKTMIYRFLILNFAGWAFS-------FAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSL 1339
+Q F++RF + + D +Y LI F +GC F L D G+R+ L+ + + + + Q+ S W Q + +SG+ L+ T + E P HI +F+ L Y Y + + WR L+ +IF + VPE+PR+L+ R +A +++ AK NK T+ + +++ G + L +K I +I+ + F Y G+ ++ F T+ V+G+V + ++ +K GR+K + S IC +I + SL
Sbjct: 82 NQTDFKRRFGQ--------MKSDGTYYLSDVRTGLIVGIFNIGCAFGGLTLGRLGDMYGRRIGLMCVVLVYIVGIVIQIASSDKWYQYFIGRIISGMGVGGIAVLSPTLISETAP-KHIRGTCVSFYQLMITLGIFLGYCTNYGTKDYSNSV--QWRVPLGLNFAFAIFMIAGMLMVPESPRFLVEKGRYEDAKRSL---AKSNKVTIEDPSIVAEMDTIMANVETERLAGNASWGELFSNKGAILPRVIMGIMIQSLQQLTGNNYFFYYGTTIFNAVGMKDSFQTSIVLGIVNFASTFVALYTVDKFGRRKCLLGGSASMAICFVIFSTVGVTSL 403
BLAST of slc22a-2 vs. Ensembl Nematostella
Match: EDO45833 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRW4]) HSP 1 Score: 122.094 bits (305), Expect = 1.270e-29 Identity = 116/464 (25.00%), Postives = 206/464 (44.40%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCGLFH----YISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCL-FSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKS-VYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKE---EFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMP-------FIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMI 1522
MD + + + IGG G F +I + + I TF+ V+ + F EP + C + + T+ N T + R S+N S W F F ++++E +L+C +A L + F+G + +F LSD G+ +L SI + + ++ + +W LVL + G + VY+ L Y E + +H LA T W ++ +++ AY WR + I + ++ + +FW VPE+ RW ++N R EA +T+ IAK+N L + N + + G +L K + + + LIL F+ + Y G ++++ + LVELP G S+ ++ LG++C++ + F + V +K+ A+ K S ++ + + EL+PT RN M + + LG+ AP I
Sbjct: 1 MDIDKILSSIGGFGFFQKRNSFILGLVIFIATFQTVL----IVFVGMEPPWKCAQDSTTCTL-NGTFSSGDENYDSRCSMNRS-----DWEFTSGF--TSIVSEWDLICGKAAMASLAQSILFIGWIPGAFIIGKLSDMFGRTRMLFPSIAVVAVASLSCSFAQHLWLYLVLRAIIGFFEGGVYIVL-YVLSTEFVGPAHRSLAGTLNWVFFTLSLITLDGLAYGLHDWRHLSIAVSVPAL-PLFFFWLVPESCRWQLVNNRCKEARQTLEHIAKLNGKNLPSDVMPAINNVEEEKSFRGGILDLFKPRQQLKQTLILWFSWLTNAMVYYGVTLSAGVLGGSLYLNFLLASLVELP------------GNLFSIWFMNLLGLVCMLCLASANITLFFSQGPGHYQV----IKIISAVLGKFCISISFCTIYVTSTELLPTVIRNIGMGSMAVFDQLGASLAPFI 434
BLAST of slc22a-2 vs. Ensembl Nematostella
Match: EDO46087 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RR13]) HSP 1 Score: 122.094 bits (305), Expect = 1.746e-29 Identity = 123/519 (23.70%), Postives = 239/519 (46.05%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQL--VLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQI-YILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKP--IQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSV-SALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQ 1714
M+++H+ +G G ++ L ++ ++ L F +P + CL SST N T +K QC R Q+T + ++I E +LVC+ A+ +L+ + G L + F L+D G+R + + L+ ++ G S+ ++ L F++G C + A+ E++ S+ A ++ G + + + AY+ + WR + +LSL S+F +L+F +VPE+ RWLM+ R +EA + IA N + K P + G F++L + ++ + +L F + + Y G + + + +I++ F+ L+E P N GR+K++ + + G+ C+ M F++ +S S L AM K G ++++ + I + E+ PT RN + + ++ +G I AP + V L Y ++ + L+ +PETH P+P+T++ + + E+ D++ +
Sbjct: 1 MEFDHVLKIVGEFGPHQRRLYVLLCLSIVPAAIQLLLLVFVAAQPHWICLN---SST--NETCPKNKLQCTER-----------QYTSKY----TSIITEWDLVCENAYKADLVQSLLMSGTLLGALMFGALADKYGRRRVWHTT--LTGLVVFGFASSFAPTFKIYATLRFLTGFCIGGEILSAFVLATELVGPSYRGFAGIMAQCFFTLGLLILPMVAYLIQDWRTLSVVLSLPASVF-ILFFRYVPESARWLMIRGRVSEAENILLDIALKNGIAVPKSLLQVNHPFFVGSRYG-FFDLFCTRKIVKQTFVLIFIWFVNTLVYYGLSLNTKHLAGDIYMNFFLCSLMEFPAYLTCLFFVNWAGRRKTLFNYMVLAGLACMACM-FVQPES--SPADRTLATVFAMIGKFGITASFALIYIYSAEIFPTVVRNVGLGVCSMSSRIGGICAPFV--VFLGTYMRPLPMVIFGMCAFMAGLLSLMLPETHKRPLPETMDDKMFKANDSDFEYDDDLVTE 490
BLAST of slc22a-2 vs. Ensembl Nematostella
Match: EDO36723 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SHW3]) HSP 1 Score: 120.553 bits (301), Expect = 5.942e-29 Identity = 112/474 (23.63%), Postives = 209/474 (44.09%), Query Frame = 2
Query: 290 LTFALYEPKFSCLVKNISSTIRNSTNL-ISKDQCQ------YRLSVNDS-WNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVG-CLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPV--------PQTIEQA 1660
+ F YEP + C + + + NST I Q R +N + W D +E +T++ + +LVCD +F+ L + F G L + +++D G+R +L S IT + W + L F SG + + E++ + L++T W ++ M + L AY + W+ + I+S + +F +++ F+PE+ RWL++ R+++A + + +AK+NK + KE+ P+ + F L + L+ +A Y + +I++ + +VE P L N+ GRK +V + +G I +++ FI + + ++ +V KL ++++ + + EL PT RN+ M L+ + +G+ AP + L + PF L S L + + + F+PET P PQ +EQ
Sbjct: 40 MVFVAYEPPWMCTTNSSACLLSNSTGREIYSTSTQPIELYHRRCKLNRTDWKFADPELYEGPV--HTIVTQFDLVCDNSFHAWLANSMLFFGWALGAIILGMIADKYGRRSVLFPSAACVIAITFSMSFAQASWVVIALRFFSGFFLGGSILTMFVLAAELVGPAKRALSSTMVWFYFTLALMVLGLQAYFIKDWKLLCIISTVPFVFIFIFWKFIPESVRWLLVVGRKDQAREILEQVAKVNKKEMPKEDLR--VPVVKHNRGFLELFGTPRLALLTLLQCYAWLVNGLVYYAVSMSAGDFGGSIYLNFVLTSIVEFPANILVIDNCNRFGRKHTVVWYTVVGAISCLVVSFIPSGT-DNIGYIAGRVAAGTLGKLCITTSFNSLYVFSAELFPTMIRNSGMGLLSVISRVGAALAPFVVQ-LTRINAILPFALMSGLTFLAALACW-FLPETRGKPTLEVMGDDDPQHLEQG 506
BLAST of slc22a-2 vs. Ensembl Nematostella
Match: EDO36696 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SHW2]) HSP 1 Score: 120.553 bits (301), Expect = 6.281e-29 Identity = 106/423 (25.06%), Postives = 193/423 (45.63%), Query Frame = 2
Query: 290 LTFALYEPKFSCLVKNISSTIRNSTNL-ISKDQCQ------YRLSVNDS-WNKCDQWTFEKRFMRNTLINELNLVCDRAF----YRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMI 1522
+ F YEP + C + + + NST I Q R +N + W D +E +T++ E +LVCD +F ++F + +G +F I++D G+ +L S L +++ + W LVL F G + + E++ + LA T W ++ M +AL A+ R W + I+S+ +F VL++ FVPE+ RWL++ + +A + + +A++NK ++ +EE + P + L K + L+ +A + Y G + +I++ + LVE P L N+ GRK++V A + +G I I + FI A + ++ +V M KL ++++ + + EL PT RN+ M L+ + +G+ AP +
Sbjct: 40 MVFVAYEPPWMCSTNSSACLLSNSTGREIYSTSTQPIELYHRRCKLNRTDWKFADPELYEGPV--HTIVTEFDLVCDHSFTAWMANSMLFFGWAIGAIF---LGIIADKYGRCSVLFPSAILVMGLSLAMAFVKKAWLVLVLRFFIGFFEGGGFLSMFVLATELVGPAKRALAGTLVWIYFTAALMVLALKAFFIRDWSTLCIISIAPFVFIVLFWKFVPESVRWLLVTGSKGKARRILENVARVNKKSMPEEEL--FAPQVEHNRGIIELFSTKRLAVLTLLQCYAWFVNGMVYYGVSMSAGDFGGSIYLNFVLTSLVEFPANVLLIHNCNRFGRKRTVVAYTLIGAIACITVSFIPAGT-NNLGFIIGRVTGGMLGKLCITTSFNGLYVFSAELFPTMVRNSGMGLLSVISRVGAALAPFV 454
BLAST of slc22a-2 vs. Ensembl Nematostella
Match: EDO42875 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZZ3]) HSP 1 Score: 118.627 bits (296), Expect = 3.689e-28 Identity = 96/364 (26.37%), Postives = 167/364 (45.88%), Query Frame = 2
Query: 269 YVVEFQGL--TFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWNKCD----QWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPF-SILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNK----EEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSV------SALSGLGIICLI 1309
+VV FQ + TF EP + C V+N ST+ N T + Y+L +CD W F K F + + + +LVC+ + ++ + + F G L F LSD G+R ++ + +S W ++ + GV + + E + V H ++AAT W ++ +M+ LFAY R WR + I +T + + ++WF+PE+ RWL++ R EA + +A N+ + E NK K F +L +++ M+ R LIL FA + Y G + ++++ F+ +VE+P + + GRKKSV ++L+ +G + L+
Sbjct: 32 FVVGFQTMLMTFITGEPGWQC-VEN--STVCNVTGVHRPGGDHYKL-------RCDLPRSDWEFAKEF--TSTVTQWDLVCEDSIFQGVSSSVIFAGWLLGAIFIGWLSDRTGRRYVVYFGSLGLLAAAVVSALSPFFWLFVLSRAIVGVMIGGSSLCQFILMTEFVGVRHRNVAATLVWFAWTCAFMATPLFAYFIRDWRILTIAVTVTGVPFSFFWWFIPESMRWLLVKGRVTEAEAILRDVAAFNRKKMPDEGLLEPLNKGK-----VADFRDLFRNRKMVQRTLILWFAWLVNAMVYYGVSLSSPSLGGSMYLNFFLTSIVEIPANFAAIYSMKRFGRKKSVVIPMILASLAAMGAVLLV 378
BLAST of slc22a-2 vs. Ensembl Medaka
Match: slc22a5 (solute carrier family 22 member 5 [Source:NCBI gene;Acc:101165246]) HSP 1 Score: 139.043 bits (349), Expect = 1.447e-34 Identity = 155/573 (27.05%), Postives = 257/573 (44.85%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGL--TFALYEPKFSCLVK--NISSTIRNS----TNLISKD---QC-QYRLSVNDSWN------------------KC-DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQ--LVLSFVSGVCKSVYVS---LAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGKFW---NLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMI-----HSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPSKQLDTE 1765
DY+ A +G G + +++F L+ T F GL FA PK CL+ N++ RN+ T + +D QC +Y+L V + + +C D WT+ K ++T++ E NLVCD + ++ FVG LF S LSD G++ ++ +S+ + + + Q S Q W+ ++ FV S+Y+S L L + + V L A F Y GYM++ A+ R WR + + TS+ Y+ +WF+ E+PRWL+ R EA + A+ NK F + + + G+ + ++LK K + L+ + + Y G + + + S N F+ F+ + E+P +S ++ R+ +S LG L+++ FI +SV Q + + L M K GF+ A+ I I T EL PT RN M + +GSI AP I + +L + G + S ++ + F+PET H +P+T+EQ + K IQ G H QL+ +
Sbjct: 3 DYDEDTAFLGQTGPYFWVTFFLLN--TVFVSTGFNGLYIIFAGATPKHHCLIPDVNLTEEWRNAIIPFTEVDGEDIKSQCSRYKLDVVKNLSSEGYVPGRDVNLTSLQQEECLDGWTYSKEIYQSTIVTEWNLVCDNQWKVPFASSSLFVGYLFGSLISGQLSDRFGRKKVVFMSLAVQCLSVLLQSFS-QSWKMFCIIFLFVGASQISIYISAFVLGTEVLSKTMRVLFTTLGAFLF---YCIGYMTLPWIAFGIRDWRTLLAVLSATSVVYIPLWWFISESPRWLVTQGRVVEAEAIVRDAARRNKVAAPPVIFKESEIQEMPAGRKYTMLDILKFKKLRCITLMCLLLWMSINIGYFGLSLNTSNLSGNPFMNCFLSAISEVPAYIVSTLLLRVSPRRILLSVFLFLGGGVLLLIQFIP----ESVQQ--VALALEMTGKFGFTMAFSIVYIYTAELYPTVLRNVGMGVCSSAARIGSITAPYIIYLGTYDKVLPYILMGSLTISSSMVNL-------FLPETLHKDLPETVEQMQECQGLCRRSKKRKCIQN----GATHNSLSQLEAK 552
BLAST of slc22a-2 vs. Ensembl Medaka
Match: si:dkey-166k12.1 (solute carrier family 22 member 13 [Source:NCBI gene;Acc:101165571]) HSP 1 Score: 130.568 bits (327), Expect = 9.304e-32 Identity = 116/504 (23.02%), Postives = 213/504 (42.26%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWNKCDQ------WTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKE-EFNKWKPI--QQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQA 1660
M+++ + A IGG G + I ++ + + F P C + + NL D + N+ ++ W + ++ + E +LVC+RA L + + G L S F ++D G+R +L++SI L T+ + + ++L F G S + A+ E LA + GYM +A AY+ R WR++ + + Y +P++ RWL+ N R EA + A +N L + KW+ + + + +L++ M R +IL + + Y G + ++ N+++T FV GL+E+P L I R+ S+S +G + ++M + D P + LAM K G ++++ I + T E+ PT R T + + + +G + AP+I+ +L + L+ + L+ +PET P+P T+E A
Sbjct: 1 MNFDQILAAIGGFGKYQKILYIWICLPQILLAFHMMVSIFTGATPPHQCRDSFSTGAGNQTLNLSLPDASCFSADALPPGNRTERVPCGRGWVYSSEVFESSTVTEWDLVCNRAGLNSLGSSVYMSGLLVGSVVFGAMADRYGRRFVLLLSIALQTVFGVAVAFAPNFPVYVLLRFAVGTTISGVIINAFVLGTEWTCTKRRMLAGIITDYTFGLGYMLLAGVAYLIRDWRKLQLAISAPGFLLIFYIRVLPQSARWLLANDRTEEAIALLRKAALVNGRVLPPAVQVEKWEILGGSKRSHSAVDLVRTPQMRKRTVILFYIWFVNVLVYYGLSLGVSRLGTNLYMTQFVFGLIEIPARSLVLIFL-PFSRRLSLSGFLAVGGLACLLMLTVPED------HPNVLTGLAMVGKFGITASFAIIYVYTAEIFPTVVRQTGIGVSSMFARMGGVLAPIIN--MLDSHSPATPLIIFGTSPLLGALLALALPETADRPLPDTLEDA 495
BLAST of slc22a-2 vs. Ensembl Medaka
Match: slc22a21 (solute carrier family 22 member 5-like [Source:NCBI gene;Acc:101164991]) HSP 1 Score: 126.331 bits (316), Expect = 2.475e-30 Identity = 131/528 (24.81%), Postives = 229/528 (43.37%), Query Frame = 2
Query: 185 YEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVK---NISSTIRNST-----NLISKDQC-QYRL---------------SVNDSW---NKC-DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLV--LSFVSGVCKSVYVSLAYTTLIEI-IPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEF-----NKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQ 1657
+E A +G G F F L ++T + + F P CLV N+++ RN++ + +C +YRL VN S C D W ++ ++T+I+E +LVCD ++ + + FF G L SF LSD G+++++ +I + T+ T Q S W FV G S YV+ A+ EI +P + ++ GYM + L A++ R WR + + +WF+PE+PRWL+ R +EA + A+IN F N+ +P + +LL + + + + L + S +Y + + N++ F+ LVE+P LS +M R+ S+ + +G + L+I+ + + ++ + L M K ++A+ + T E+ PT R TA++ + +GSI +P V L+ Y + L + + L+ +PETH +P+P TI
Sbjct: 15 FEESTAFLGQWGRFQKQVFFALCLSTVPNGLIVMSIVFLADTPPHHCLVPAHLNLTAAWRNASIPLEGGARTPSRCSRYRLEDLLSFSEGNLLPGVDVNLSTVPTEGCFDGWEYDHSVYKSTIISEWDLVCDDSWKNPMTSSVFFCGVLTGSFLSGQLSDRYGRKIVMFATIVIQTVATFVQAFSTS-WAMFCAFFFFVGGGNISNYVT-AFVLGAEILVPRIRTIFSTAGVSLFFALGYMLLPLLAFLIRDWRMLLFGLTVPGCLCAPLWWFIPESPRWLLSQGREDEAEAIIRKAAEINNVEPPTVIFASSLKNEEEPEKTRALNICDLLHSRNIRWISITLWLVWNSLSISYFALSLNTANLIGNVYFNCFLSALVEIPAYSLSWLMFRFCPRRFSIFPMLFMGGVVLLIIHLLPTALV------YVSITLEMIGKFAVTTAYALVYAYTAEVYPTVLRTTALASCSMASRIGSIISPFF--VYLRNYSVSLPHILMGSLTVLMGLLSLLLPETHGMPLPDTITH 532
BLAST of slc22a-2 vs. Ensembl Medaka
Match: slc22a21 (solute carrier family 22 member 5-like [Source:NCBI gene;Acc:101164991]) HSP 1 Score: 126.331 bits (316), Expect = 3.340e-30 Identity = 129/528 (24.43%), Postives = 230/528 (43.56%), Query Frame = 2
Query: 185 YEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVK---NISSTIRNST-----NLISKDQC-QYRLSVNDSWNK------------------C-DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLV--LSFVSGVCKSVYVSLAYTTLIEI-IPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEF-----NKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQ 1657
+E A +G G F F L ++T + + F P CLV N+++ RN++ + +C +YRL S+++ C D W ++ ++T+I+E +LVCD ++ + + FF G L SF LSD G+++++ +I + T+ T Q S W FV G S YV+ A+ EI +P + ++ GYM + L A++ R WR + + +WF+PE+PRWL+ R +EA + A+IN F N+ +P + +LL + + + + L + S +Y + + N++ F+ LVE+P LS +M R+ S+ + +G + L+I+ + + ++ + L M K ++A+ + T E+ PT R TA++ + +GSI +P V L+ Y + L + + L+ +PETH +P+P TI
Sbjct: 15 FEESTAFLGQWGRFQKQVFFALCLSTVPNGLIVMSIVFLADTPPHHCLVPAHLNLTAAWRNASIPLEGGARTPSRCSRYRLEDLLSFSEGNLLPGVDVNLSTVPTEGCFDGWEYDHSVYKSTIISEWDLVCDDSWKNPMTSSVFFCGVLTGSFLSGQLSDRYGRKIVMFATIVIQTVATFVQAFSTS-WAMFCAFFFFVGGGNISNYVT-AFVLGAEILVPRIRTIFSTAGVSLFFALGYMLLPLLAFLIRDWRMLLFGLTVPGCLCAPLWWFIPESPRWLLSQGREDEAEAIIRKAAEINNVEPPTVIFASSLKNEEEPEKTRALNICDLLHSRNIRWISITLWLVWNSLSISYFALSLNTANLIGNVYFNCFLSALVEIPAYSLSWLMFRFCPRRFSIFPMLFMGGVVLLIIHLLPTALV------YVSITLEMIGKFAVTTAYALVYAYTAEVYPTVLRTTALASCSMASRIGSIISPFF--VYLRNYSVSLPHILMGSLTVLMGLLSLLLPETHGMPLPDTITH 532
BLAST of slc22a-2 vs. Ensembl Medaka
Match: oatx (solute carrier family 22 member 6 [Source:NCBI gene;Acc:101155455]) HSP 1 Score: 125.561 bits (314), Expect = 6.328e-30 Identity = 119/436 (27.29%), Postives = 203/436 (46.56%), Query Frame = 2
Query: 428 DQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLF-SFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAK-------INKCTLNKEEFNKWKPIQQVTGKFW--NLLKHKTMIYRFLILNFAGW-AFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMP--FIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFA-FIPETHHLPVPQTIEQAVSLLIHKEQEW 1693
D WTF++ +T ++E LVC +++I + + G L + + LSD G+RL+LI S ++ ++S + F++G+ S + ++ +E IP + T ++FG M +A AY + WR + + + Y W+ E+ RWL++N+R +A K++ +A+ INK T+ + K I+ F +L++ + M R I A W + SFAY G A DL +I++ + G V++P L+ M + LGR+ VS +S L + +II F+ D L+ LA K S+++ + T EL PT R T M V +GS+ AP + +L + + A P + FA F+PET ++P+P T+E E++W
Sbjct: 117 DGWTFDQSEFISTTVSEWGLVCSLRPLKQMIQSIYMGGVLTGAIIYGSLSDRFGRRLVLIWSYLQIGVLGCSSVLSSSFSVYCIFRFLNGMAVSGVILNGFSLKVEWIPTKTRTVVGTLTSFFFTFGQMILAGLAYWLKDWRMLQLSVSAPHFLFFAYSWWYSESARWLVVNRRSEDALKSLHRVARINGKPEVINKLTVEVLHSHMRKEIESSRSSFSAIDLMRTRGM-RRISICLVAVWFSTSFAYYGLAMDLQKFGVSIYLMQVIFGAVDIPAKLLALGMLSYLGRR--VSQVSCLFLSAVIIFANIFVPTDMQT------LRTTLACLGKAFTSASFTTVYLYTGELYPTVIRQTGMGFVSTMARVGSMAAPAVL-ILDEVWPALP--SIVYGGAAVLASGFACFLPETLNIPLPDTVEDV-------EEKW 533
BLAST of slc22a-2 vs. Planmine SMEST
Match: SMESG000004219.1 (SMESG000004219.1) HSP 1 Score: 1063.52 bits (2749), Expect = 0.000e+0 Identity = 532/535 (99.44%), Postives = 534/535 (99.81%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPSKQLDTEFDKFLL 1783
MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYM VALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGL+ELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFLLYSLLLLITVVLVFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPS+QLDTEFDKFLL
Sbjct: 1 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMLVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLIELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFLLYSLLLLITVVLVFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKLGMVHRPSEQLDTEFDKFLL 535
BLAST of slc22a-2 vs. Planmine SMEST
Match: SMESG000064528.1 (SMESG000064528.1) HSP 1 Score: 187.578 bits (475), Expect = 3.957e-52 Identity = 150/527 (28.46%), Postives = 262/527 (49.72%), Query Frame = 2
Query: 179 MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLI-SKDQCQYRLSVNDSWNK---CDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGV-CKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWR-QIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSI---FAPMIHSV--LLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAEKL 1726
M+YE ++I G F+ ++ +TLS+ ++ + F + P + C+ I N T L + +CQ + N C W + K M NT+ E NLVC++ Y L+ T FFVG +I D IG+ L+ +++ II I + IW ++L F+SG+ +Y L Y T EI+ + L N+W LY GYM + AY + WR ++++ + + L ++ +PE+PRWL + + +A + IAK N + +F+ +Q G ++ K M + +L F S +Y G + + +F S NIF+ F+ GL+E TGP++ IM++KL R+ S+ + +CL++ F S ++ + L K ++A+ I D+ NE+ PT RN + ++I +G+ SI FAP I+ + + ++ + S++ LI+ +L++ F+PET P+PQT+E+ L E + +MI + ++L
Sbjct: 1 MNYEEAISEIQGNERFNVLALLTLSMMACISSMDINSIVFIGHTPSYKCV-----DPIFNQTQLTWTVKECQAIARSENGTNHTIYCRNWKYNKTDMTNTISTEFNLVCNKKKYVTLMNTMFFVGMSVGNFIAICGDKIGRMRLIHLAVIWEIIINICLPFATNIWLIILLRFLSGLGTGKIYQGLCYLT--EIVSIKRRSLYTNNYWILYVLGYMLIPGLAYGTKDWRLSRHLMNF--PLLFYLTYFLLPESPRWLGIGGKFKKAITNLLLIAKYNGKIFPENKFDSLIITKQKLGNITDIFGSKIMRLKMFVLIFVHGTISVSYFGLSINESFLSSNIFLNVFIQGLLETFTGPVAWIMSSKLNRRVSMLINFLICSVCLMLNNFY---SFNNIIVSIVISTLGSIGKFALTTAYCICDMYLNEVFPTPIRNMS---IFIILGIASIFTVFAPSINGIDEFIPYFSCSCY---SVMCLISGLLIYFFLPETKGCPLPQTLEEGNELRKGNENNY-CNMILKHDEL 508
BLAST of slc22a-2 vs. Planmine SMEST
Match: SMESG000025785.1 (SMESG000025785.1) HSP 1 Score: 181.03 bits (458), Expect = 1.246e-49 Identity = 147/504 (29.17%), Postives = 252/504 (50.00%), Query Frame = 2
Query: 224 FHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLN--KEEFNKWKPIQQVTGKF--WNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLG-IICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAE 1720
F I+F+ LS+ F+Y +FQ L ++ P F+C S I+ ISKDQC +++N S KC WTF T++++ +LVCD + +L+ ++ L + F L+D G++++ I+ + + T+ T + ++ + G +S Y + Y L+E++ ++A + FW S L Y+ R+WR ++SL SI YVL FVPE+PRWL + ++ + +++ IA INK L EE I++ T ++ WN K ++ FA ++ S DL S NI+I+ FV+GL+E P LS + RK+ ++ S G I + + + D +S+++ + ++G L +S+ + + EL PTT R+ ++ I + + A I+ L QFY P L+Y LL +I+ L+F F+PET LP+P+TI L+ +EQE+ M +++
Sbjct: 16 FKVIAFLILSLPAFQYGSQFQNLLVSIRTPNFTCQYNETSHQIQ-----ISKDQCT--MTINGSNVKCQHWTFSSEPFGETIMSDYDLVCDYKYVGDLLVLLWYSTSLMAPVFGWLADKYGRKMISIIFLSIETVATFILAFTPNLYSHIFFRLCIGFSESAY-HICYVWLMEMVNKDFRNVAGSFFWLYGSVAMTVFPLTVYVTRNWRLTQLISLTPSILYVLIL-FVPESPRWLCVKNKKQQLMESLQTIANINKMDLQLTPEEIK----IEKTTKEWNKWNAFKDMNFLFLASTSLFAVFSISILISAILIDLNLLSSNIYISMFVLGLMEFPGALLSYLSMYFFKRKRMITIFSMFGSIFIFLSVTLSKVDKWQSIFR---MIFGSIGKVLVMTSSQGVL-VYATELFPTTHRSLFFGMLQIILLMAMTAAVYINK-LNQFYGFIPMLIYFLLNMISCCLIFVFMPETKGLPIPETIFDQRLLVKEREQEYLEYMYNRSD 501
BLAST of slc22a-2 vs. Planmine SMEST
Match: SMESG000025819.1 (SMESG000025819.1) HSP 1 Score: 168.703 bits (426), Expect = 3.802e-45 Identity = 132/513 (25.73%), Postives = 247/513 (48.15%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAE 1720
DY N F +++F LS+ +F++ + Q + + Y PK++CL + S I IS DQC + ++ S C++W F + T++++ +LVCD ++I ++ + SD G++ + I ++ L TI T + + ++ + G+ + + + Y L+E++ + + + W YM L AY + WR ++SLI +I Y L F PE+PRWL + R++E K+++ IA+INK N + P + W LK KT R + ++ + Y A +L S N++I+ F++GL+E P S + RK S + G+G I ++I F + L WQ +++ AK+ ++ + +EL PT+ R+ + + + L S A + + L F P ++Y +L+ +T +++ ++PET +LP+P+T+ L ++KE+E+ M ++ E
Sbjct: 9 DYNKRNT-------FKFLAFFILSLPSFQFSSQMQNILISTYTPKYTCLYNSSFSKIS-----ISADQCN--MIIDGSTIVCNKWNFLYEPVGRTMMSDFSLVCDYKNLGDIILIVWYSTSITGPIMGWFSDKFGRKKVAIFNLCLETISTFFVSFTPDVTSNIICRLLIGISANGFYT-CYVWLMEMVDNEFREFSGSFIWTYGCLAYMVFPLTAYFTKDWRITQLISLIPNILYFLILLF-PESPRWLCVTNRKSELIKSLNKIAEINKIDTNINYEQIFVPKTKDEHNTWKALKDKTFSLRMTLSFLLVFSINLIYAAIAVNLQILSNNMYISMFLLGLMEFPGILFSYVSLRFFRRKTSFILIGGIGSIFILISVFFSRNIL---WQGVIRIIFGCIAKIAVTTCNQSTMVYVSELCPTSHRSLGFASIQL-ANLCSFTAAIYINKLSTVLFFLPMVIYFILMFLTSCIIYLYLPETKNLPIPETLLDQKMLKVNKEKEFLDYMNKKRE 501
BLAST of slc22a-2 vs. Planmine SMEST
Match: SMESG000025822.1 (SMESG000025822.1) HSP 1 Score: 167.933 bits (424), Expect = 7.584e-45 Identity = 131/513 (25.54%), Postives = 247/513 (48.15%), Query Frame = 2
Query: 182 DYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLVKNISSTIRNSTNLISKDQCQYRLSVNDSWNKCDQWTFEKRFMRNTLINELNLVCDRAFYRELIFTTFFVGCLFSFPFSILSDSIGKRLLLIVSIFLSTIITIGQMVSYQIWQQLVLSFVSGVCKSVYVSLAYTTLIEIIPVSHIDLAATNFWNLYSFGYMSVALFAYIFRSWRQIYILSLITSIFYVLYFWFVPETPRWLMLNKRRNEAFKTMSFIAKINKCTLNKEEFNKWKPIQQVTGKFWNLLKHKTMIYRFLILNFAGWAFSFAYIGSATDLTFASENIFITTFVMGLVELPTGPLSGIMANKLGRKKSVSALSGLGIICLIIMPFIEADSLKSVWQPWLKVCLAMGAKLGFSSAWLIFDIITNELIPTTDRNTAMSLVYITVGLGSIFAPMIHSVLLQFYFAGPFXXXXXXXXXXXXXXFAFIPETHHLPVPQTIEQAVSLLIHKEQEWKMDMIQQAE 1720
DY N F +++F LS+ +F++ + Q + + Y PK++CL + S I IS DQC + ++ S C++W F + T++++ +LVC+ ++I ++ + SD G++ + I ++ L TI T + + ++ + G+ + + + Y L+E++ + + + W YM L AY + WR ++SLI +I Y L F PE+PRWL + R++E K+++ IA+INK N + P + W LK KT R + ++ + Y A +L S N++I+ F++GL+E P S + RK S + G+G I ++I F + L WQ +++ AK+ ++ + +EL PT+ R+ + + + L S A + + L F P ++Y +L+ +T +++ ++PET +LP+P+T+ L ++KE+E+ M ++ E
Sbjct: 9 DYNKRNT-------FKFLAFFILSLPSFQFSSQMQNILISTYTPKYTCLYNSSFSKIS-----ISADQCN--MIIDGSTIVCNKWNFSYEPVGRTMMSDFSLVCNYKNLGDIILIVWYSTSITGPIMGWFSDKFGRKKVAIFNLCLETISTFFVSFTPDVTSNIICRLLIGISANGFYT-CYVWLMEMVDNEFREFSGSFIWTYGCLAYMVFPLTAYFTKDWRITQLISLIPNILYFLILLF-PESPRWLCVTNRKSELIKSLNKIAEINKIDTNINYEQIFVPKTKDEHNTWKALKDKTFSLRMTLSFLLVFSINLIYAAIAVNLQILSNNMYISMFLLGLMEFPGILFSYVSLRFFRRKTSFILIGGIGSIFILISVFFSRNIL---WQGVIRIIFGCIAKIAVTTCNQSTMVYVSELCPTSHRSLGFASIQL-ANLCSFTAAIYINKLSTVLFFLPMVIYFILMFLTSCIIYLYLPETKNLPIPETLLDQKMLKVNKEKEFLDYMNKKRE 501 The following BLAST results are available for this feature:
BLAST of slc22a-2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of slc22a-2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of slc22a-2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of slc22a-2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of slc22a-2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of slc22a-2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of slc22a-2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of slc22a-2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of slc22a-2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of slc22a-2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of slc22a-2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of slc22a-2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of slc22a-2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of slc22a-2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30025639 ID=SMED30025639|Name=slc22a-2|organism=Schmidtea mediterranea sexual|type=transcript|length=1875bpback to top protein sequence of SMED30025639-orf-1 >SMED30025639-orf-1 ID=SMED30025639-orf-1|Name=SMED30025639-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=536bp MDYEHLNAKIGGCGLFHYISFMTLSITTFKYVVEFQGLTFALYEPKFSCLback to top protein sequence of SMED30025639-orf-2 >SMED30025639-orf-2 ID=SMED30025639-orf-2|Name=SMED30025639-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=119bp MSSFVIISNINQALENPNLAPMARHTLSHGCQTDFKESASMKGIIIKHMIback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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