Xeroderma pigmentosum, complementation group C

Overview
NameXeroderma pigmentosum, complementation group C
Smed IDSMED30025592
Length (bp)1666
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Xeroderma pigmentosum, complementation group C (SMED30025592) t-SNE clustered cells

Violin plots show distribution of expression levels for Xeroderma pigmentosum, complementation group C (SMED30025592) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Xeroderma pigmentosum, complementation group C (SMED30025592) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Xeroderma pigmentosum, complementation group C (SMED30025592) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30025592

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30025592SMESG000075170.1 SmedASXL_010184SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
neoblastSMED30025592SMESG000075170.1 dd_Smed_v4_5100_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neuronSMED30025592SMESG000075170.1 Contig33220newmark_estsPMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
neuronSMED30025592SMESG000075170.1 Contig33220uc_Smed_v2PMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Human
Match: XPC (XPC complex subunit, DNA damage recognition and repair factor [Source:HGNC Symbol;Acc:HGNC:12816])

HSP 1 Score: 195.282 bits (495), Expect = 6.752e-53
Identity = 97/246 (39.43%), Postives = 147/246 (59.76%), Query Frame = 1 
Query:  895 LEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPFVE-----LFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHL 1617
            LE+  E  +KW+ VD  +      L+          Y + +D+DG+++D+  +YD  W T +R+ R+    ++  +R +Q P   + +K E+ E +A+ +DQ +P+ +   K HP++ LK HLLKYE +YP      G+ R EAVY RD V+  H+++TWLK+A+V+R GE+P K VK   +R ++  +      E     LFG WQ EEY PPVA +G VPRN +GNV LF PSM+P+GC  L+L
Sbjct:  532 LEVFCEQEEKWVCVDCVHGVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVDAEWWAETLRPYQSPF-MDREKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNL 776
[Close]
BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Celegans
Match: xpc-1 (XPC (Xeroderma Pigmentosum group C) DNA repair gene homolog [Source:UniProtKB/TrEMBL;Acc:Q9N4C3])

HSP 1 Score: 117.472 bits (293), Expect = 3.021e-27
Identity = 73/240 (30.42%), Postives = 121/240 (50.42%), Query Frame = 1 
Query:  919 QKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSE---VSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYP--ADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPFVELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHLKG 1623
            ++WI VD  +      LS          Y  ++DN   + +++ +Y  +      R+R +    V+++  +  F    ++E  K E  ++R  L+ + +P+ +++ K HP++ L+  LLK+E +YP  A     G  R   VY R  V+    +  WLK A+ ++ GE P K VK     R   E   D F++++G WQ E+Y  P   NG +P N YGNV +F  +M P+ CT+L L G
Sbjct:  735 KRWICVDPLHKSVDEPLSIHEHSASPISYVFAIDNKQGICEVSQRYAMDCVKQDFRRRRTNPKWVAWTLFLPPFA--ANSERKKWEMMQMREDLVKRPLPTVMSEYKNHPLYALEKDLLKFEAIYPPPATQKPLGQIRGHNVYPRSTVFTLQGENNWLKLARSVKIGEKPYKIVKARPDPRIPVEDREDKFLDVYGYWQTEKYRRPPLKNGKIPHNEYGNVYMFNENMCPLDCTYLKLSG 972
[Close]
BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Fly
Match: Xpc (gene:FBgn0004698 transcript:FBtr0087374)

HSP 1 Score: 177.563 bits (449), Expect = 6.332e-47
Identity = 96/247 (38.87%), Postives = 147/247 (59.51%), Query Frame = 1 
Query:  895 LEILDEINQKWIPVDARNADSWNDLSHVMRDH-PKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSF--QRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVS-RRKEKEVGSDPFVELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHLKG 1623
            +E+  ++ ++WI +D       + +  + ++  P   Y  +  +D  +KD+ A+Y  +W+TT R+ R+ +      I  +  +R   T+ D  E+ ++R    D+ +P ++++ K HP++VL+ HLLK++ LYP D  + GF R EAVY RD V+L H++E WLK A+V++ GE P K VK      R  + V  D  +E+FG WQ +EY PP A NGIVPRNAYGNV+LFK  MLP    HL L G
Sbjct:  962 VEVWSDVEEQWICIDLFKG-KLHCVDTIRKNATPGLAYVFAFQDDQSLKDVTARYCASWSTTVRKARVEKAWLDETIAPYLGRR---TKRDITEDDQLRRIHSDKPLPKSISEFKDHPLYVLERHLLKFQGLYPPDAPTLGFIRGEAVYSRDCVHLLHSREIWLKSARVVKLGEQPYKVVKARPKWDRLTRTVIKDQPLEIFGYWQTQEYEPPTAENGIVPRNAYGNVELFKDCMLPKKTVHLRLPG 1204
[Close]
BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Fly
Match: Xpc (gene:FBgn0004698 transcript:FBtr0087373)

HSP 1 Score: 177.178 bits (448), Expect = 6.698e-47
Identity = 96/246 (39.02%), Postives = 143/246 (58.13%), Query Frame = 1 
Query:  895 LEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSF--QRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVS-RRKEKEVGSDPFVELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHLKG 1623
            +E+  ++ ++WI +D          +      P   Y  +  +D  +KD+ A+Y  +W+TT R+ R+ +      I  +  +R   T+ D  E+ ++R    D+ +P ++++ K HP++VL+ HLLK++ LYP D  + GF R EAVY RD V+L H++E WLK A+V++ GE P K VK      R  + V  D  +E+FG WQ +EY PP A NGIVPRNAYGNV+LFK  MLP    HL L G
Sbjct:  963 VEVWSDVEEQWICIDLFKGKLHCVDTIRKNATPGLAYVFAFQDDQSLKDVTARYCASWSTTVRKARVEKAWLDETIAPYLGRR---TKRDITEDDQLRRIHSDKPLPKSISEFKDHPLYVLERHLLKFQGLYPPDAPTLGFIRGEAVYSRDCVHLLHSREIWLKSARVVKLGEQPYKVVKARPKWDRLTRTVIKDQPLEIFGYWQTQEYEPPTAENGIVPRNAYGNVELFKDCMLPKKTVHLRLPG 1205
[Close]
BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Zebrafish
Match: xpc (xeroderma pigmentosum, complementation group C [Source:ZFIN;Acc:ZDB-GENE-030131-8461])

HSP 1 Score: 209.92 bits (533), Expect = 2.514e-58
Identity = 102/245 (41.63%), Postives = 153/245 (62.45%), Query Frame = 1 
Query:  895 LEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPF----VELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHL 1617
            LE+  E + +W+ VD         L       P   Y + +D++GFMKDL ++YD  W T+SRR+R+    +   +  ++ P DTE  + E+ E++A+L+D+ +P+++++ K HP++VLK HLLKYE LYPA     G+ R E VY RD V+  H+++TWLKEA+ +R GE P K V    +R ++  + S+      + LFG WQ EEY PP+A +G VPRN +GNV +FK  MLP+GC H+HL
Sbjct:  469 LEVYLESSGRWVCVDVDQGVGQPQLCSDQATLP-ITYVVGLDDEGFMKDLGSRYDPTWLTSSRRRRVDSEWWEETMELYKSP-DTERGQKEDQEMQAKLLDKPLPTSVSEYKNHPLYVLKRHLLKYEALYPATAAVLGYCRGEPVYSRDCVHTLHSRDTWLKEARTVRLGEEPYKMVLGFSNRSRKARMMSEQKNVKDLALFGTWQTEEYQPPIAVDGKVPRNEFGNVYMFKSCMLPIGCVHVHL 711
[Close]
BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Zebrafish
Match: xpc (xeroderma pigmentosum, complementation group C [Source:ZFIN;Acc:ZDB-GENE-030131-8461])

HSP 1 Score: 209.534 bits (532), Expect = 2.537e-58
Identity = 102/245 (41.63%), Postives = 153/245 (62.45%), Query Frame = 1 
Query:  895 LEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPF----VELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHL 1617
            LE+  E + +W+ VD         L       P   Y + +D++GFMKDL ++YD  W T+SRR+R+    +   +  ++ P DTE  + E+ E++A+L+D+ +P+++++ K HP++VLK HLLKYE LYPA     G+ R E VY RD V+  H+++TWLKEA+ +R GE P K V    +R ++  + S+      + LFG WQ EEY PP+A +G VPRN +GNV +FK  MLP+GC H+HL
Sbjct:  438 LEVYLESSGRWVCVDVDQGVGQPQLCSDQATLP-ITYVVGLDDEGFMKDLGSRYDPTWLTSSRRRRVDSEWWEETMELYKSP-DTERGQKEDQEMQAKLLDKPLPTSVSEYKNHPLYVLKRHLLKYEALYPATAAVLGYCRGEPVYSRDCVHTLHSRDTWLKEARTVRLGEEPYKMVLGFSNRSRKARMMSEQKNVKDLALFGTWQTEEYQPPIAVDGKVPRNEFGNVYMFKSCMLPIGCVHVHL 680
[Close]
BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Xenopus
Match: zp4.2 (zona pellucida glycoprotein 4, gene 2 [Source:Xenbase;Acc:XB-GENE-1219044])

HSP 1 Score: 186.422 bits (472), Expect = 8.946e-50
Identity = 91/211 (43.13%), Postives = 132/211 (62.56%), Query Frame = 1 
Query: 1003 YCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPF------VELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHL 1617
            Y + +DN G +KD+  +YD +W T++R++R+    +   +  ++ P D + +  E  E+  +L+DQ +P+++   K HP++VLK HLLKYE +YP      G+ R EAVY R  V+  H+ +TWLKEA+V+R  E+P K VK   S R  K   SDP       + L+G WQ EEY PP+A +G VPRN YGNV LF+P MLP+GC HL +
Sbjct:  685 YVVGIDNAGCVKDVTRRYDVDWMTSTRKRRVEPDWWEETLMPYKNP-DADREDREEVELEFKLLDQPLPTSITGYKDHPLYVLKRHLLKYEAIYPETAAILGYCRGEAVYSRSCVHTLHSSDTWLKEARVVRLAEVPYKMVKGY-SNRARKARSSDPQKKDHNDLGLYGLWQTEEYQPPLAVDGKVPRNEYGNVYLFQPCMLPIGCAHLRV 893
[Close]
BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Mouse
Match: Xpc (xeroderma pigmentosum, complementation group C [Source:MGI Symbol;Acc:MGI:103557])

HSP 1 Score: 191.815 bits (486), Expect = 7.617e-52
Identity = 94/247 (38.06%), Postives = 151/247 (61.13%), Query Frame = 1 
Query:  895 LEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPFVE------LFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHL 1617
            LE+  E   KW+ VD  +      ++          Y + +D+DG+++D+  +YD  W T +R+ R+    ++  +R + R + TE +K E+ E +A+ +DQ +P++++  K HP++ LK HLLK++ +YP      G+ R EAVY RD V+  H+++TWLK+A+V+R GE+P K VK   +R ++  + S+P +       L+G WQ EEY PP+A +G VPRN +GNV LF PSM+PVGC  + L
Sbjct:  525 LEVYCEPQAKWVCVDCVHGVVGQPVACYKYATKPMTYVVGIDSDGWVRDVTQRYDPAWMTATRKCRVDAEWWAETLRPY-RSLLTEREKKEDQEFQAKHLDQPLPTSISTYKNHPLYALKRHLLKFQAIYPETAAVLGYCRGEAVYSRDCVHTLHSRDTWLKQARVVRLGEVPYKMVKGFSNRARKARL-SEPQLHDHNDLGLYGHWQTEEYQPPIAVDGKVPRNEFGNVYLFLPSMMPVGCVQMTL 769
[Close]
BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Mouse
Match: Xpc (xeroderma pigmentosum, complementation group C [Source:MGI Symbol;Acc:MGI:103557])

HSP 1 Score: 97.4413 bits (241), Expect = 9.398e-21
Identity = 47/148 (31.76%), Postives = 84/148 (56.76%), Query Frame = 1 
Query:  895 LEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLR 1338
            LE+  E   KW+ VD  +      ++          Y + +D+DG+++D+  +YD  W T +R+ R+    ++  +R + R + TE +K E+ E +A+ +DQ +P++++  K HP++ LK HLLK++ +YP      G+ R EAVY R
Sbjct:  524 LEVYCEPQAKWVCVDCVHGVVGQPVACYKYATKPMTYVVGIDSDGWVRDVTQRYDPAWMTATRKCRVDAEWWAETLRPY-RSLLTEREKKEDQEFQAKHLDQPLPTSISTYKNHPLYALKRHLLKFQAIYPETAAVLGYCRGEAVYSR 670
[Close]
BLAST of Xeroderma pigmentosum, complementation group C vs. UniProt/SwissProt
Match: sp|Q01831|XPC_HUMAN (DNA repair protein complementing XP-C cells OS=Homo sapiens OX=9606 GN=XPC PE=1 SV=4)

HSP 1 Score: 195.282 bits (495), Expect = 3.243e-52
Identity = 97/246 (39.43%), Postives = 147/246 (59.76%), Query Frame = 1 
Query:  895 LEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPFVE-----LFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHL 1617
            LE+  E  +KW+ VD  +      L+          Y + +D+DG+++D+  +YD  W T +R+ R+    ++  +R +Q P   + +K E+ E +A+ +DQ +P+ +   K HP++ LK HLLKYE +YP      G+ R EAVY RD V+  H+++TWLK+A+V+R GE+P K VK   +R ++  +      E     LFG WQ EEY PPVA +G VPRN +GNV LF PSM+P+GC  L+L
Sbjct:  532 LEVFCEQEEKWVCVDCVHGVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVDAEWWAETLRPYQSPF-MDREKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNL 776
[Close]
BLAST of Xeroderma pigmentosum, complementation group C vs. UniProt/SwissProt
Match: sp|P51612|XPC_MOUSE (DNA repair protein complementing XP-C cells homolog OS=Mus musculus OX=10090 GN=Xpc PE=1 SV=2)

HSP 1 Score: 191.815 bits (486), Expect = 5.328e-51
Identity = 94/247 (38.06%), Postives = 151/247 (61.13%), Query Frame = 1 
Query:  895 LEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPFVE------LFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHL 1617
            LE+  E   KW+ VD  +      ++          Y + +D+DG+++D+  +YD  W T +R+ R+    ++  +R + R + TE +K E+ E +A+ +DQ +P++++  K HP++ LK HLLK++ +YP      G+ R EAVY RD V+  H+++TWLK+A+V+R GE+P K VK   +R ++  + S+P +       L+G WQ EEY PP+A +G VPRN +GNV LF PSM+PVGC  + L
Sbjct:  525 LEVYCEPQAKWVCVDCVHGVVGQPVACYKYATKPMTYVVGIDSDGWVRDVTQRYDPAWMTATRKCRVDAEWWAETLRPY-RSLLTEREKKEDQEFQAKHLDQPLPTSISTYKNHPLYALKRHLLKFQAIYPETAAVLGYCRGEAVYSRDCVHTLHSRDTWLKQARVVRLGEVPYKMVKGFSNRARKARL-SEPQLHDHNDLGLYGHWQTEEYQPPIAVDGKVPRNEFGNVYLFLPSMMPVGCVQMTL 769
[Close]
BLAST of Xeroderma pigmentosum, complementation group C vs. UniProt/SwissProt
Match: sp|Q24595|XPC_DROME (DNA repair protein complementing XP-C cells homolog OS=Drosophila melanogaster OX=7227 GN=Xpc PE=1 SV=2)

HSP 1 Score: 177.563 bits (449), Expect = 6.347e-46
Identity = 96/247 (38.87%), Postives = 147/247 (59.51%), Query Frame = 1 
Query:  895 LEILDEINQKWIPVDARNADSWNDLSHVMRDH-PKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSF--QRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVS-RRKEKEVGSDPFVELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHLKG 1623
            +E+  ++ ++WI +D       + +  + ++  P   Y  +  +D  +KD+ A+Y  +W+TT R+ R+ +      I  +  +R   T+ D  E+ ++R    D+ +P ++++ K HP++VL+ HLLK++ LYP D  + GF R EAVY RD V+L H++E WLK A+V++ GE P K VK      R  + V  D  +E+FG WQ +EY PP A NGIVPRNAYGNV+LFK  MLP    HL L G
Sbjct:  962 VEVWSDVEEQWICIDLFKG-KLHCVDTIRKNATPGLAYVFAFQDDQSLKDVTARYCASWSTTVRKARVEKAWLDETIAPYLGRR---TKRDITEDDQLRRIHSDKPLPKSISEFKDHPLYVLERHLLKFQGLYPPDAPTLGFIRGEAVYSRDCVHLLHSREIWLKSARVVKLGEQPYKVVKARPKWDRLTRTVIKDQPLEIFGYWQTQEYEPPTAENGIVPRNAYGNVELFKDCMLPKKTVHLRLPG 1204
[Close]
BLAST of Xeroderma pigmentosum, complementation group C vs. UniProt/SwissProt
Match: sp|P87235|RHP42_SCHPO (DNA repair protein rhp42 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rhp42 PE=3 SV=1)

HSP 1 Score: 128.257 bits (321), Expect = 6.667e-30
Identity = 96/279 (34.41%), Postives = 140/279 (50.18%), Query Frame = 1 
Query:  886 IFTLEILDEINQKWIPVDA--RNADSWNDLS-------HVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPI---------DTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYP----ADVDSFGFWRK---EAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKT---MVSRRKEKEV----GSDPFVE-LFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHLKG 1623
            IF  EI D+  +KWI VDA   N    ND++       +    H +     + DND + KD+  +Y      +SR +++  VSF+     F + I         D E D  E  E+ +++  +  P + AD K HP FVL  HL + E L P        +FG  +K   E VYLR +V +  T E + KE +VI+ GE P K VK     +SR++E E      ++P ++ L+   Q E YVPP   +GI+P+N YGN+D F  SM+P G  HL  +G
Sbjct:  324 IFWTEIYDQSEKKWIAVDAVVLNGVYTNDMTWFEPKGAYAESKHLRMGIVAAYDNDLYAKDVTLRYTD--YQSSRLKKIRHVSFADKYFDFYKAIFGQLAKRNKDAE-DIYEEKELESKVPIRE-PKSFADFKNHPEFVLIRHLRREEALLPNAKPVKTATFGNGKKATSEEVYLRKDVVICKTPENYHKEGRVIKEGEQPRKMVKARAVTISRKREHEFRVAETNEPVLQGLYSSDQTELYVPPPIKDGIIPKNGYGNMDCFVESMIPKGAAHLPYRG 598
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BLAST of Xeroderma pigmentosum, complementation group C vs. UniProt/SwissProt
Match: sp|Q10445|RHP41_SCHPO (DNA repair protein rhp41 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rhp41 PE=3 SV=1)

HSP 1 Score: 110.153 bits (274), Expect = 4.715e-24
Identity = 97/358 (27.09%), Postives = 154/358 (43.02%), Query Frame = 1 
Query:  646 IFAAILRQAAIKTRLVSALYPVFLKKYTSKSQEATEGILCPP---------------TVHKPSTRGGRSK--NPQKSKIAKTFLFNLPTKAQLNSTI-----IFTLEILDEINQKWIPVD----ARNADSWNDLSHVMRDH-PKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQR----LSEVSFSRIIRSFQRPIDTEND--KIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRK----EAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPFVELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTH 1608
            +FA+ILR   + TRLV +L  V   ++     EA+   + P                + H  S    R K   P  S ++     ++ T+      I     +F +E  ++  QKW+ VD    A     +        DH  +  Y  +++ +G++KD+  KY  ++    + +       +   +RI     +P D  ND   IE++E+      +G+P  + DLK HP+FVL+ HL K + +      S G        E VY R  V    + E W ++ ++I+PG  P K VK             D  + L+     + Y P      IVP+NAYGN+DL+ PSMLP G  H
Sbjct:  202 LFASILRNLNVPTRLVFSL-QVLSFRFKGAINEASSHEIVPAWSQQMENDSSSDISESAHITSRFRKRRKIIQPSFSNLSHLDASDIVTEDTKLKVIDSPKPVFWVEAFNKAMQKWVCVDPFGDASVIGKYRRFEPASSDHLNQMTYVFAIEANGYVKDVTRKYCLHYYKILKNRVEIFPFGKAWMNRIFSKIGKPRDFYNDMDAIEDAELLRLEQSEGIPRNIQDLKDHPLFVLERHLKKNQAIKTGK--SCGRINTKNGVELVYPRKYVSNGFSAEHWYRKGRIIKPGAQPLKHVKN-----------GDKVLPLYDEEATQLYTPKPVVANIVPKNAYGNIDLYVPSMLPYGAYH 545
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BLAST of Xeroderma pigmentosum, complementation group C vs. TrEMBL
Match: W5N629 (Xeroderma pigmentosum, complementation group C OS=Lepisosteus oculatus OX=7918 PE=4 SV=1)

HSP 1 Score: 219.55 bits (558), Expect = 9.558e-59
Identity = 111/247 (44.94%), Postives = 157/247 (63.56%), Query Frame = 1 
Query:  895 LEILDEINQKWIPVDA-RNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRK-----EKEVGSDPFVELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHL 1617
            LE+  E + KW+ VD  R A +   L +     P   Y + +DN GF+KDL  +YD  W T++R++R+ E  +   + S++ P  TE D+ E+ E++A+L+DQ +P+ +++ K HP++ LK HLLKYE LYP      G+ R EAVY RD V+  H+K+TWLKEA+V+R GE+P K VK   +R +     E E  +   + LFG WQ EEY PPVA +G VPRN YGNV LF+P MLP+GC HL +
Sbjct:  406 LEVYLEESGKWVCVDCVRPAVALPQLCYKQATKP-VTYVVGIDNGGFVKDLTKRYDPTWMTSTRKRRVDEEWWEETLESYKSPF-TERDEKEDMELQAKLLDQPLPTAISEYKSHPLYALKRHLLKYEALYPPTAAILGYCRGEAVYSRDCVHTLHSKDTWLKEARVVRLGEVPYKMVKGFSNRARKARLLEAENRNKVDLPLFGHWQTEEYQPPVAVDGKVPRNEYGNVYLFRPCMLPIGCVHLQV 650
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BLAST of Xeroderma pigmentosum, complementation group C vs. TrEMBL
Match: A0A3B1JVN2 (Xeroderma pigmentosum, complementation group C OS=Astyanax mexicanus OX=7994 PE=4 SV=1)

HSP 1 Score: 211.846 bits (538), Expect = 4.119e-56
Identity = 104/245 (42.45%), Postives = 153/245 (62.45%), Query Frame = 1 
Query:  895 LEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPFVE----LFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHL 1617
            +E+  +  + W+ VD         L      HP   Y + VD +G++KDL+ +YD  W T+SRR+R+    +   +  +  P +TE +K E+ E++ RL+D+ +P++++  K HP++VL+ HLLKYE LYP      G+ R EAVY RD V+  H+++TWLKEA+ +R GE+P K VK   +R ++  + S+   E    LFGPWQ EEY PP+A +G VPRN +GNV +FKP MLPVGC HL L
Sbjct:  386 IEVYLDSVKGWVCVDVNQGVGKPQLCTNQASHP-VTYVVGVDGEGYLKDLSTRYDPTWLTSSRRRRIDSEWWEETLGFYVSP-ETEREKKEDKELQDRLLDKPLPTSISQYKNHPLYVLERHLLKYEALYPRTAAILGYCRGEAVYSRDCVHTLHSRDTWLKEARTVRLGEVPYKMVKGFSNRSRKARMMSERKDEKDLALFGPWQTEEYQPPLAVDGRVPRNEFGNVYMFKPCMLPVGCAHLRL 628
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BLAST of Xeroderma pigmentosum, complementation group C vs. TrEMBL
Match: A0A437D6A0 (Uncharacterized protein OS=Oryzias javanicus OX=123683 GN=OJAV_G00062960 PE=4 SV=1)

HSP 1 Score: 212.231 bits (539), Expect = 9.948e-56
Identity = 108/245 (44.08%), Postives = 149/245 (60.82%), Query Frame = 1 
Query:  895 LEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPF----VELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHL 1617
            LE+  E +  W+ VD  +      L       P   Y ++VD DGF+KDL  KYD  W TTSR++R+ +  +   ++ F  P D E D  E  E++++L+++ +P ++A+ K HP++ LK HLLKYE LYPA     G+ R E VY RD V   H+++TWLKEA+ +R GE P K VK   +R ++  + S+      + LFG WQ EEY PP+A +G VPRN YGNV LFKP MLPVGC HL L
Sbjct:  509 LEVFLEKSSSWVCVDVEHGVGMPQLCSQNATEP-VTYVVAVDGDGFLKDLGRKYDPTWMTTSRKRRVDDDWWEETLQFFLGPED-ERDAKEEKELQSKLLNKPLPISVAEYKNHPLYALKRHLLKYEALYPATATVLGYCRGEPVYSRDCVRTLHSRDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMASEQKDHKDLGLFGEWQTEEYQPPIAVDGKVPRNEYGNVYLFKPCMLPVGCVHLRL 751
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BLAST of Xeroderma pigmentosum, complementation group C vs. TrEMBL
Match: A0A3S5A1T5 (Uncharacterized protein OS=Protopolystoma xenopodis OX=117903 GN=PXEA_LOCUS3127 PE=4 SV=1)

HSP 1 Score: 204.912 bits (520), Expect = 1.039e-55
Identity = 128/399 (32.08%), Postives = 203/399 (50.88%), Query Frame = 1 
Query:  550 EMIQMNDESGNIRNILINSFNKKCVSSLWINVIFAAILRQAAIKTRLVSALYPVFLKKYTSKSQEATEGILCPPTVHKPSTRGGRSKNPQKSKIAKTFLFNLPTKAQLNSTIIFTLEILDEINQKWIP-------------VDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMK--------DLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTE------------------NDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSD--PFVELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHLKG 1623
            +++ +N  S   R+I+    NK C     + ++  A LR      RL+ +  P+ L+    K Q+     L   ++  P+      K   ++K+       + ++++ +S I      LD   + ++P             VDA++    N+  +V+        C+   +   +         DLA++YD NW   SRR R+    +++II  F+R  + +                   D  +  EIR +L+ Q  P  + D K HP++ LK HLLK+E+++P DV+  G+  KEA+Y RD +YL HT+E+WLKEA++IR GE P K V+  +S +++    SD  P V+++G WQ E YVPPVA NG VPRN YGNV+LFKP MLP+GC H+ L G
Sbjct:  105 DLVPLNASSTR-RSIVERLANKTCTQYDPL-ILLVAALRSLGFDVRLLVSFSPLHLRPSNRKVQQLAN--LIKKSLKLPAEDKQDVKKAHETKV-------ISSESETDSEIALNKPCLDLFIEVFLPSDNRWICPTLNPHVDAKDKPDLNNRLYVIGLSSTKPICIPGKDVIILPQYVGRSPIDLASRYDENWCVLSRRIRMPNDQWTKIIEFFRRKFNLDAAGNHAIVEPTKDNVLLMRDLQDAQEIRVKLLSQPFPKRVQDYKNHPLYALKRHLLKFEIIFPPDVNPLGYVGKEAIYSRDCLYLCHTRESWLKEARIIRLGEKPAKVVRARLSMKRKLLQDSDEPPTVDVYGQWQTEPYVPPVALNGKVPRNEYGNVELFKPCMLPIGCVHIRLSG 492
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BLAST of Xeroderma pigmentosum, complementation group C vs. TrEMBL
Match: A0A3P8VAI2 (Xeroderma pigmentosum, complementation group C OS=Cynoglossus semilaevis OX=244447 PE=4 SV=1)

HSP 1 Score: 211.846 bits (538), Expect = 1.283e-55
Identity = 109/245 (44.49%), Postives = 147/245 (60.00%), Query Frame = 1 
Query:  895 LEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPFVE----LFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHL 1617
            LE+  +    W+ VD  +      L       P   Y +SVD DGF+KDL  KYD  W T+SR++R+ +  +   +  F  P D E DK E  E++ RL+++ +P ++A+ K HP++ LK HLLKYE +YP+     G+ R E VY RD V   H+++TWLKEA+ +R GE P K VK   +R ++  + SD   E    LFG WQ EEY PP+A +G VPRN YGNV LFKP MLPVGC HL L
Sbjct:  507 LEVYLDKTASWVCVDVEHGVGVPKLCSQNATAP-VTYVVSVDGDGFLKDLGKKYDPTWMTSSRKRRVDDEWWEETLAPFLGPED-ERDKKEEKELQNRLLNKPLPISIAEYKNHPLYALKRHLLKYEAIYPSTATVLGYCRGEPVYSRDCVQTLHSRDTWLKEARTVRLGEEPYKMVKGFSNRSRKARIMSDTKNENDLALFGEWQTEEYQPPIAVDGKVPRNEYGNVYLFKPCMLPVGCVHLRL 749
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BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Cavefish
Match: xpc (xeroderma pigmentosum, complementation group C [Source:ZFIN;Acc:ZDB-GENE-030131-8461])

HSP 1 Score: 211.846 bits (538), Expect = 1.560e-59
Identity = 104/245 (42.45%), Postives = 153/245 (62.45%), Query Frame = 1 
Query:  895 LEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPFVE----LFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHL 1617
            +E+  +  + W+ VD         L      HP   Y + VD +G++KDL+ +YD  W T+SRR+R+    +   +  +  P +TE +K E+ E++ RL+D+ +P++++  K HP++VL+ HLLKYE LYP      G+ R EAVY RD V+  H+++TWLKEA+ +R GE+P K VK   +R ++  + S+   E    LFGPWQ EEY PP+A +G VPRN +GNV +FKP MLPVGC HL L
Sbjct:  386 IEVYLDSVKGWVCVDVNQGVGKPQLCTNQASHP-VTYVVGVDGEGYLKDLSTRYDPTWLTSSRRRRIDSEWWEETLGFYVSP-ETEREKKEDKELQDRLLDKPLPTSISQYKNHPLYVLERHLLKYEALYPRTAAILGYCRGEAVYSRDCVHTLHSRDTWLKEARTVRLGEVPYKMVKGFSNRSRKARMMSERKDEKDLALFGPWQTEEYQPPLAVDGRVPRNEFGNVYMFKPCMLPVGCAHLRL 628
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BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Sea Lamprey
Match: xpc (xeroderma pigmentosum, complementation group C [Source:ZFIN;Acc:ZDB-GENE-030131-8461])

HSP 1 Score: 194.512 bits (493), Expect = 9.054e-55
Identity = 98/241 (40.66%), Postives = 144/241 (59.75%), Query Frame = 1 
Query:  922 KWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRK-----EKEVGSDPFVELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHLKGKN 1629
            +W+ V+   A +    + V R      Y ++ D+DG MKD+  +YD  W T++RR R+    +   +  F+ P  T  ++ E+ ++ A L+ + +PS++++ K HP++ L  HLLKYE ++P      G  R E VY R+ V+  H+ +TWLK+A+V+R GE+P K VK   +R +     + E    P + LFG WQ EEY PPVA +G VPRN YGNV LF+PSMLPVGC HLH  G N
Sbjct:  243 RWVCVEVAGAQADRPEACVRRAARPLAYVVAFDDDGCMKDITRRYDPAWLTSTRRLRVDAEWWQAALFPFESP-HTHREQQEDEQLEAGLLSRPMPSSVSEFKSHPLYALPRHLLKYEAIFPPGAAVLGTCRGEPVYARECVHTLHSCDTWLKQARVVRLGEVPYKMVKGQSNRSRKLRMADPESRDKPDLALFGLWQTEEYQPPVAVDGKVPRNDYGNVYLFRPSMLPVGCVHLHAPGLN 482
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BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Yeast
Match: RAD4 (Protein that recognizes and binds damaged DNA (with Rad23p) during NER; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins; Rad4p-Rad23p heterodimer binds to promoters of DNA damage response genes to repress their transcription in the absence of DNA damage; NER stands for nucleotide excision repair [Source:SGD;Acc:S000000964])

HSP 1 Score: 85.5001 bits (210), Expect = 5.964e-18
Identity = 64/262 (24.43%), Postives = 122/262 (46.56%), Query Frame = 1 
Query:  886 IFTLEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYC---------LSVDNDGFMKDLAAKYDRNWATTSRRQRLS-----EVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEA-------VYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKV-KTMVSRRKEKEVGSDPFVELFGPWQVEEYVPPVA-CNGIVPRNAYGNVDLFKPSMLPVGC 1602
            IF  E+ D+ ++KWI VD  N  +   +    +  PK + C         ++ D     +D+  +Y +   +  R++R++     E  F ++I +      T+ D  E+     R   +G+P ++ DLK HP +VL+  + + +++ P      G+ +          VY + ++    +   W    ++++ G   CKKV K  V R K +    D    L+     E Y+PP+A  +G + +N +GN+++F P+M+P  C
Sbjct:  314 IFWCEVWDKFSKKWITVDPVNLKTIEQVRLHSKLAPKGVACCERNMLRYVIAYDRKYGCRDVTRRYAQWMNSKVRKRRITKDDFGEKWFRKVITALHHRKRTKIDDYEDQYFFQRDESEGIPDSVQDLKNHPYYVLEQDIKQTQIVKPG-CKECGYLKVHGKVGKVLKVYAKRDIADLKSARQWYMNGRILKTGS-RCKKVIKRTVGRPKGEAEEEDE--RLYSFEDTELYIPPLASASGEITKNTFGNIEVFAPTMIPGNC 571
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BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Nematostella
Match: EDO36142 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJD6])

HSP 1 Score: 161.384 bits (407), Expect = 1.649e-45
Identity = 80/198 (40.40%), Postives = 126/198 (63.64%), Query Frame = 1 
Query: 1033 MKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGE-IPCKKVKTMVSRRKEKEVGSDPFVELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHLKG 1623
            +KD+  +Y  NW T ++RQR+    +   + S+ RP + + +++ENS ++ +  D+ +P ++ + K HP++VL+ HLLK+E +YP    + GF R EAVY RD V+L HT+E W+ EA V++  + +    +   + + K    G +P +ELFG WQ E+Y PP A +G VPRN YGNV+LFKP+MLP G  H+ + G
Sbjct:    1 VKDVTCRYAPNWLTKTQRQRVDADWWEETLASY-RPKNKKMEELENSLLQEKQQDKPLPQSIGEFKNHPLYVLRRHLLKFEAIYPESAATQGFIRGEAVYSRDCVHLLHTREKWMNEALVVKHLKYVYYAHMCFDIIQNKPVLDGKEPTIELFGRWQTEDYKPPPAVDGKVPRNEYGNVELFKPTMLPPGTRHIKIPG 197
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BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Medaka
Match: xpc (XPC complex subunit, DNA damage recognition and repair factor [Source:NCBI gene;Acc:101168367])

HSP 1 Score: 205.297 bits (521), Expect = 8.845e-57
Identity = 105/245 (42.86%), Postives = 148/245 (60.41%), Query Frame = 1 
Query:  895 LEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPF----VELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHL 1617
            LE+  E +  W+ VD  +      L       P   Y ++VD + F+KDL  KYD  W T SR++R+ +  +   ++ F  P D E D  E  E++++L+++ +P ++A+ K HP++ LK HLLKYE LYPA     G+ R E VY RD V+  H+++TWLKEA+ +R GE P K VK   +R ++  + S+      + LFG WQ EEY PP+A +G VPRN YGNV LFKP MLPVGC HL L
Sbjct:  490 LEVFLEKSSSWVCVDVEHGVGMPHLCSQNATEP-VTYVVAVDGNRFLKDLGKKYDPTWMTASRKRRVDDDWWEETLQPFLGPED-ERDVKEEKELQSKLLNKPLPVSVAEYKNHPLYALKRHLLKYEALYPATATVLGYCRGEPVYSRDCVHTLHSRDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMASEQKDHKDLGLFGDWQTEEYQPPIAVDGKVPRNEYGNVYLFKPCMLPVGCVHLRL 732
[Close]
BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Medaka
Match: xpc (XPC complex subunit, DNA damage recognition and repair factor [Source:NCBI gene;Acc:101168367])

HSP 1 Score: 205.297 bits (521), Expect = 1.129e-56
Identity = 105/245 (42.86%), Postives = 148/245 (60.41%), Query Frame = 1 
Query:  895 LEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPF----VELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHL 1617
            LE+  E +  W+ VD  +      L       P   Y ++VD + F+KDL  KYD  W T SR++R+ +  +   ++ F  P D E D  E  E++++L+++ +P ++A+ K HP++ LK HLLKYE LYPA     G+ R E VY RD V+  H+++TWLKEA+ +R GE P K VK   +R ++  + S+      + LFG WQ EEY PP+A +G VPRN YGNV LFKP MLPVGC HL L
Sbjct:  517 LEVFLEKSSSWVCVDVEHGVGMPHLCSQNATEP-VTYVVAVDGNRFLKDLGKKYDPTWMTASRKRRVDDDWWEETLQPFLGPED-ERDVKEEKELQSKLLNKPLPVSVAEYKNHPLYALKRHLLKYEALYPATATVLGYCRGEPVYSRDCVHTLHSRDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMASEQKDHKDLGLFGDWQTEEYQPPIAVDGKVPRNEYGNVYLFKPCMLPVGCVHLRL 759
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BLAST of Xeroderma pigmentosum, complementation group C vs. Planmine SMEST
Match: SMESG000075170.1 (SMESG000075170.1)

HSP 1 Score: 1060.06 bits (2740), Expect = 0.000e+0
Identity = 533/536 (99.44%), Postives = 534/536 (99.63%), Query Frame = 1 
Query:   34 MPKISLKRKSSSNDNNQIKEKCKNFDNLYTESEKENLAEINNNITIIRLPEGILXXXXXXXXXXXXXXXXSELDDKSDIVINIYDEDFKELHDVVDEKRIQQKLERELRENCHRTMLMALIGRLFYINRILSDKNDLITHLAFSCLPENNSKFKPWSELKSKQLFCNLLKQFEMIQMNDESGNIRNILINSFNKKCVSSLWINVIFAAILRQAAIKTRLVSALYPVFLKKYTSKSQEATEGILCPPTVHKPSTRGGRSKNPQKSKIAKTFLFNLPTKAQLNSTIIFTLEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPFVELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHLKGKNLFLA 1641
            MPKISLKRKSSSNDNNQIKEKCKNFDNLYTESEKENLAEINNNITIIRLPEGILDVSEDEEVDDCEWENVSELDDKSDIVINIYDEDFKELHDVVDEKRIQQKLERELRENCHRTMLMALIGRLFYINRILSDKNDLITHLAFSCLP+NNSKFKPWSELKSKQLFCNLLKQFEMIQMNDESGNIRNILINSFNKKCVSSLWINVIFAAILRQAAIKTRLVSALYPVFLKKYTSKSQEATEGILCPPTVHKPSTRGGRSKNPQKSKIAKTF FNLPTKAQLNSTIIFTLEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRL EVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPFVELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHLKGKNLFLA
Sbjct:    1 MPKISLKRKSSSNDNNQIKEKCKNFDNLYTESEKENLAEINNNITIIRLPEGILDVSEDEEVDDCEWENVSELDDKSDIVINIYDEDFKELHDVVDEKRIQQKLERELRENCHRTMLMALIGRLFYINRILSDKNDLITHLAFSCLPDNNSKFKPWSELKSKQLFCNLLKQFEMIQMNDESGNIRNILINSFNKKCVSSLWINVIFAAILRQAAIKTRLVSALYPVFLKKYTSKSQEATEGILCPPTVHKPSTRGGRSKNPQKSKIAKTFSFNLPTKAQLNSTIIFTLEILDEINQKWIPVDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSRRQRLYEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKGHPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKEAKVIRPGEIPCKKVKTMVSRRKEKEVGSDPFVELFGPWQVEEYVPPVACNGIVPRNAYGNVDLFKPSMLPVGCTHLHLKGKNLFLA 536
The following BLAST results are available for this feature:
BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1
Match NameE-valueIdentityDescription
XPC6.752e-5339.43XPC complex subunit, DNA damage recognition and re... [more]
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BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
xpc-13.021e-2730.42XPC (Xeroderma Pigmentosum group C) DNA repair gen... [more]
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BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Xpc6.332e-4738.87gene:FBgn0004698 transcript:FBtr0087374[more]
Xpc6.698e-4739.02gene:FBgn0004698 transcript:FBtr0087373[more]
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BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
xpc2.514e-5841.63xeroderma pigmentosum, complementation group C [So... [more]
xpc2.537e-5841.63xeroderma pigmentosum, complementation group C [So... [more]
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BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
zp4.28.946e-5043.13zona pellucida glycoprotein 4, gene 2 [Source:Xenb... [more]
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BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Xpc7.617e-5238.06xeroderma pigmentosum, complementation group C [So... [more]
Xpc9.398e-2131.76xeroderma pigmentosum, complementation group C [So... [more]
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BLAST of Xeroderma pigmentosum, complementation group C vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q01831|XPC_HUMAN3.243e-5239.43DNA repair protein complementing XP-C cells OS=Hom... [more]
sp|P51612|XPC_MOUSE5.328e-5138.06DNA repair protein complementing XP-C cells homolo... [more]
sp|Q24595|XPC_DROME6.347e-4638.87DNA repair protein complementing XP-C cells homolo... [more]
sp|P87235|RHP42_SCHPO6.667e-3034.41DNA repair protein rhp42 OS=Schizosaccharomyces po... [more]
sp|Q10445|RHP41_SCHPO4.715e-2427.09DNA repair protein rhp41 OS=Schizosaccharomyces po... [more]
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BLAST of Xeroderma pigmentosum, complementation group C vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
W5N6299.558e-5944.94Xeroderma pigmentosum, complementation group C OS=... [more]
A0A3B1JVN24.119e-5642.45Xeroderma pigmentosum, complementation group C OS=... [more]
A0A437D6A09.948e-5644.08Uncharacterized protein OS=Oryzias javanicus OX=12... [more]
A0A3S5A1T51.039e-5532.08Uncharacterized protein OS=Protopolystoma xenopodi... [more]
A0A3P8VAI21.283e-5544.49Xeroderma pigmentosum, complementation group C OS=... [more]
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BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
xpc1.560e-5942.45xeroderma pigmentosum, complementation group C [So... [more]
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BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
xpc9.054e-5540.66xeroderma pigmentosum, complementation group C [So... [more]
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BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
RAD45.964e-1824.43Protein that recognizes and binds damaged DNA (wit... [more]
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BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO361421.649e-4540.40Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Xeroderma pigmentosum, complementation group C vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
xpc8.845e-5742.86XPC complex subunit, DNA damage recognition and re... [more]
xpc1.129e-5642.86XPC complex subunit, DNA damage recognition and re... [more]
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BLAST of Xeroderma pigmentosum, complementation group C vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000075170.10.000e+099.44SMESG000075170.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30025592 ID=SMED30025592|Name=Xeroderma pigmentosum, complementation group C|organism=Schmidtea mediterranea sexual|type=transcript|length=1666bp
TATATAAATCTTATATGAATATTGCAAATATTAATGCCAAAAATCAGTCT
CAAACGAAAGTCAAGTTCTAATGATAATAACCAAATAAAAGAAAAATGTA
AAAATTTTGATAATTTATATACTGAATCCGAAAAAGAAAATCTTGCTGAA
ATTAATAATAATATTACTATTATTAGATTACCTGAAGGTATTTTAGACGT
TAGTGAAGATGAAGAAGTTGACGATTGTGAGTGGGAAAATGTTTCTGAAT
TAGACGATAAATCAGATATAGTGATTAATATTTACGATGAAGATTTTAAA
GAACTACACGATGTTGTTGATGAAAAGCGTATTCAACAAAAACTTGAAAG
AGAATTAAGAGAAAATTGCCATAGAACCATGCTTATGGCTTTAATCGGGC
GCTTATTTTATATAAATCGAATATTGAGTGATAAAAATGATTTGATAACG
CATTTAGCTTTTTCGTGTCTTCCTGAAAATAACTCAAAATTTAAACCATG
GAGTGAGTTAAAATCAAAACAATTATTTTGCAATTTGCTTAAGCAATTTG
AAATGATACAAATGAATGATGAATCAGGCAACATTCGAAATATATTAATT
AATTCATTCAATAAGAAATGCGTTTCATCTTTATGGATTAATGTTATATT
TGCTGCAATACTACGACAAGCTGCAATTAAAACAAGACTCGTATCTGCTC
TTTATCCAGTATTTTTGAAGAAATATACCAGTAAGTCTCAAGAAGCCACA
GAAGGCATTCTATGTCCTCCAACTGTGCACAAACCCTCAACTAGAGGTGG
TCGGTCGAAAAATCCCCAAAAATCGAAAATAGCAAAAACATTCTTATTTA
ATCTTCCAACGAAAGCTCAATTAAATTCCACTATAATTTTCACGTTGGAA
ATTCTAGATGAAATAAATCAGAAATGGATCCCAGTGGATGCTCGCAACGC
CGACAGTTGGAATGATTTATCTCATGTAATGCGAGATCATCCAAAATTCT
TGTACTGCTTATCAGTTGATAATGACGGCTTCATGAAGGACCTGGCTGCT
AAGTACGACCGAAATTGGGCAACAACTTCGAGACGTCAGCGTTTGTCTGA
AGTTTCATTTTCTCGCATTATTAGATCGTTCCAACGACCGATTGACACGG
AAAATGACAAGATCGAAAATTCAGAGATTAGGGCTCGTTTGATCGATCAA
GGGGTGCCTTCAACCCTGGCAGATTTAAAAGGCCACCCAATTTTCGTTCT
CAAGAGTCATTTATTGAAATACGAAGTTCTATATCCAGCTGATGTTGATT
CGTTCGGATTTTGGCGGAAGGAAGCAGTTTATTTGCGCGACAATGTCTAT
TTGGCGCACACGAAGGAGACTTGGTTGAAAGAAGCAAAGGTTATTCGTCC
AGGAGAAATTCCATGTAAGAAGGTGAAAACAATGGTCTCAAGACGAAAAG
AAAAAGAAGTCGGCAGTGATCCGTTTGTAGAATTATTCGGTCCTTGGCAA
GTTGAAGAATATGTTCCTCCTGTAGCGTGTAATGGGATCGTTCCTAGGAA
TGCCTATGGAAATGTTGATTTATTTAAACCGTCTATGCTGCCTGTTGGGT
GTACGCATTTGCATCTGAAAGGTAAAAATCTATTTCTAGCATAACTCGAT
AGGGATCATGATTTTG
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protein sequence of SMED30025592-orf-1

>SMED30025592-orf-1 ID=SMED30025592-orf-1|Name=SMED30025592-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=537bp
MPKISLKRKSSSNDNNQIKEKCKNFDNLYTESEKENLAEINNNITIIRLP
EGILDVSEDEEVDDCEWENVSELDDKSDIVINIYDEDFKELHDVVDEKRI
QQKLERELRENCHRTMLMALIGRLFYINRILSDKNDLITHLAFSCLPENN
SKFKPWSELKSKQLFCNLLKQFEMIQMNDESGNIRNILINSFNKKCVSSL
WINVIFAAILRQAAIKTRLVSALYPVFLKKYTSKSQEATEGILCPPTVHK
PSTRGGRSKNPQKSKIAKTFLFNLPTKAQLNSTIIFTLEILDEINQKWIP
VDARNADSWNDLSHVMRDHPKFLYCLSVDNDGFMKDLAAKYDRNWATTSR
RQRLSEVSFSRIIRSFQRPIDTENDKIENSEIRARLIDQGVPSTLADLKG
HPIFVLKSHLLKYEVLYPADVDSFGFWRKEAVYLRDNVYLAHTKETWLKE
AKVIRPGEIPCKKVKTMVSRRKEKEVGSDPFVELFGPWQVEEYVPPVACN
GIVPRNAYGNVDLFKPSMLPVGCTHLHLKGKNLFLA*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0000429neoblast
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR018327BHD_2
IPR018326Rad4_beta-hairpin_dom1
IPR018328Rad4_beta-hairpin_dom3
IPR018325Rad4/PNGase_transGLS-fold
Vocabulary: molecular function
TermDefinition
GO:0003677DNA binding
GO:0003684damaged DNA binding
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
Vocabulary: biological process
TermDefinition
GO:0006289nucleotide-excision repair