porcupine-like protein

Query:   85 DFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIII--DKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEI---------------------PVGFEEAWKFNIKKEFQEME-----------KADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYGS 1482
            DFKFGK +G GSFSTV++A+E++T++ YA KI++K  I K+  V  V  E++V+ R++H FFV L +TFQD E+LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLHG  ++HRD+KPENILL+E+MHI+I DFG+A ++  +    + +SF GTAQ+VSPE+L                      +E    ++S            D WALGCI+YQ+++G  PF    + +EY IFQKI  L+Y+FP  F   A+D V KLLVL+  +RLG      +  LKAHP F S+ +E +  Q PP L   +  + +       N+D +                       G  +    NI++   +++           + +K+ LL+ Q   NP+H+FV N LI+K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DPS  A +W + I+ +  + Y S
Sbjct:   54 DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQS 522          

Query:   85 DFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIII--DKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEI---------------------PVGFEEAWKFNIKKEFQEME-----------KADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYGS 1482
            DFKFGK +G GSFSTV++A+E++T++ YA KI++K  I K+  V  V  E++V+ R++H FFV L +TFQD E+LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLHG  ++HRD+KPENILL+E+MHI+I DFG+A ++  +    + +SF GTAQ+VSPE+L                      +E    ++S            D WALGCI+YQ+++G  PF    + +EY IFQKI  L+Y+FP  F   A+D V KLLVL+  +RLG      +  LKAHP F S+ +E +  Q PP L   +  + +       N+D +                       G  +    NI++   +++           + +K+ LL+ Q   NP+H+FV N LI+K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DPS  A +W + I+ +  + Y S
Sbjct:   81 DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQS 549          

Query:   85 DFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIII--DKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWD 1062
            DFKFGK +G GSFSTV++A+E++T++ YA KI++K  I K+  V  V  E++V+ R++H FFV L +TFQD E+LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLHG  ++HRD+KPENILL+E+MHI+I DFG+A ++  +    + +SF GTAQ+VSPE+L                      +E    ++S            D WALGCI+YQ+++G  PF    + +EY IFQKI  L+Y+FP  F   A+D V KLLVL+  +RLG      +  LKAHP F S+ +E +  Q PP L   +  + + + D
Sbjct:   81 DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDED 371          

Query: 1933 PLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMH-YDYGGYTLDISGPVMIQTQKLTSLAFNLLDGH-RINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGY--------DDKHIPCSKKQLSSALCLSVIHGLLTAYVAPQFPYIFVCST---DY---QRMHMT----RRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQL-YHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYF 3198
            PLSN + +P+DQ+NF+VC L ++      R     SK S   R ++    G+ + LFCFG+   + L+QS +SY I++ +  +   +    + + ++ +  + R++ +DYG Y+ D SGP+MI TQK+TSLA  + DG  R ++ +   QR+    AV+++P  +++  Y   F G+LAGP   Y +Y  +I G         ++       ++   +   +V+  LL   ++  F ++ +C+T   +Y   +    T     +I++  IS    R KYYFAW++ +A   + G G+ G D+NG   W  + N     IE  +S K+ +D WNI T  WL+ + YER   F  TI  F +SA WHG YPGYYL FLT  L T  AR +R + R  FI  P  L+L Y V+T I T +A++Y   PF LL  +  L F+  +Y+
Sbjct:   14 PLSNAVQLPIDQVNFVVCQLFALLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDL---AVRRMPSLLEYLSYNCNFMGILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLF-HLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFKMFLDNWNIQTALWLKRVCYERTS-FSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFI-EPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYY 450          

Query: 1915 GSTILAPLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYW-CMAFMAIVHLYRMH-YDYGGYTLDISGPVMIQTQKLTSLAFNLLDGHRINQGIKLQQRNHESH--AVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHI-------------------PCSKKQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDYQRMHMTR---RIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQFRPIIND--KVNIMNNVFTRKAQ 3303
            GST L PLS ++GIP+DQ+NF+VC L+++      R    P   S   R  +   FGI  V+FCFG+   +L +   + Y I++   S  + H  +++  M ++ I H+ R++ + YG  T D SGP+MI TQK+T+LAF + DG     G + +  + E H  A+K  P  +++  Y   F  V+AGP    N +K+YI   + KHI                   P     +   L ++++  LL   +   FP    C  D   +H      R+ +  +     + KYYFAW++ +A   + G G+ G DKNG   W  + N +   IE+ +S K+ ++ WNI T  WL+ + Y+R P +  T+L F +SA WHG YPGYY  FLT  L T  AR VR + R  F+ S     +Y   T   T LA++Y   PF +L  +  +  +K  YF+ H++++  +L L  +P  +   +   +N++  RK  
Sbjct:   16 GSTYLHPLSELLGIPLDQVNFVVCQLVALFAAFWFRIYLRPGTTSSDVRHAVATIFGIYFVIFCFGWYSVHLFVLVLMCYAIMV-TASVSNIHRYSFFVAMGYLTICHISRIYIFHYGILTTDFSGPLMIVTQKITTLAFQVHDG----LGRRAEDLSAEQHRLAIKVKPSFLEYLSYLLNFMSVIAGPC---NNFKDYIAFIEGKHIHMKLLEVNWKRKGFHSLPEPSPTGAVIHKLGITLVSLLLFLTLTKTFP--VTCLVDDWFVHKASFPARLCYLYVVMQASKPKYYFAWTLADAVNNAAGFGFSGVDKNGNFCWDLLSNLNIWKIETATSFKMYLENWNIQTATWLKCVCYQRVPWY-PTVLTFILSALWHGVYPGYYFTFLTGILVTLAARAVRNNYRHYFLSSRALKAVYDAGTWAVTQLAVSYTVAPFVMLAVEPTISLYKSMYFYLHIISLLIILFLPMKPQAHTQRRPQTLNSINKRKTD 495          

Query:   79 ASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRIN-----HQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSE-IEVKRTSSPD--NSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNI-----EPIVQSNWDEIPVGFEEAWKFNI--------------------------------KKEFQEMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEY 1473
            ++DF F + +G G++S V   +E++T+  +A K++ K ++++ + ++ ++ EK +L  ++     H F   L   F D  R+YF+I   E G+L   L     FD+  ++F+++EI+  L++LH   +VHRD+KP+N+L+ ++ HI I DFGSA       L    FT   Q  S              YSDE   ++   +  +      SP+     ++    D W LGCI++Q L+G+ PF    + ++Y + ++I+ L + FP GF + A + ++K+LV +P  R+ +        L AH  F ++D+  I + KPP+L   I     EP   SN   +  G ++   F +                                     E  +A + + L+ Q   NPFH F  N LI+KQG L K+RGLF R+RMFLLTEGPHL Y+D   +  K EV       +E+KN   F+I T  R Y+L D   KADEW ++I  +   Y
Sbjct:   66 SNDFMFLQSMGEGAYSQVFRCREVATDAMFAVKVLQKSYLNRHQKMDAIIREKNILTYLSQECGGHPFVTQLYTHFHDQARIYFVIGLVENGDLGESLCHFGSFDMLTSKFFASEILTGLQFLHDNKIVHRDMKPDNVLIQKDGHILITDFGSAQAFGGLQLSQEGFTDANQ-ASSRSSDSGSPPPTRFYSDEEEENTARRTTFVGTALYVSPEMLADGDVGPQTDIWGLGCILFQCLAGQPPF---RAVNQYHLLKRIQELDFSFPEGFPEEASEIIAKILVRDPSTRITS------QELMAHKFFENVDWVNIANIKPPVLHAYIPATFGEPEYYSNIGPVEPGLDDRALFRLMNLGNDASASQPSTPSNVEHRGDPFVSEIAPRANSEAEKNRAARAQKLEEQRVKNPFHIFTNNSLILKQGYLEKKRGLFARRRMFLLTEGPHLLYIDVPNLVLKGEVPWTPCMQVELKNSGTFFIHTPNRVYYLFDLEKKADEWCKAINDVRKRY 565          

Query:   79 ASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRIN-----HQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTS--------SPD--NSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNI-----EPIVQSNWDEIPVGFEEAWKFNI----------------------------------KKEFQEMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEY 1473
            ++DF F + +G G++S V   +E++T+  +A K++ K ++++ + ++ ++ EK +L  ++     H F   L   F D  R+YF+I   E G+L   L     FD+  ++F+++EI+  L++LH   +VHRD+KP+N+L+ ++ HI I DFGSA       L    FT   Q  S              YSDE     E   E   +RT+        SP+     ++    D W LGCI++Q L+G+ PF    + ++Y + ++I+ L + FP GF + A + ++K+LV +P  R+ +        L AH  F ++D+  I + KPP+L   I     EP   SN   +  G ++   F +                                       E  +A + + L+ Q   NPFH F  N LI+KQG L K+RGLF R+RMFLLTEGPHL Y+D   +  K EV       +E+KN   F+I T  R Y+L D   KADEW ++I  +   Y
Sbjct:   66 SNDFMFLQSMGEGAYSQVFRCREVATDAMFAVKVLQKSYLNRHQKMDAIIREKNILTYLSQECGGHPFVTQLYTHFHDQARIYFVIGLVENGDLGESLCHFGSFDMLTSKFFASEILTGLQFLHDNKIVHRDMKPDNVLIQKDGHILITDFGSAQAFGGLQLSQEGFTDANQ-ASSRSSDSGSPPPTRFYSDE-----EVPEENTARRTTFVGTALYVSPEMLADGDVGPQTDIWGLGCILFQCLAGQPPF---RAVNQYHLLKRIQELDFSFPEGFPEEASEIIAKILVRDPSTRITS------QELMAHKFFENVDWVNIANIKPPVLHAYIPATFGEPEYYSNIGPVEPGLDDRALFRLMNLGNDASASQPSTFRPSNVEHRGDPFVSEIAPRANSEAEKNRAARAQKLEEQRVKNPFHIFTNNSLILKQGYLEKKRGLFARRRMFLLTEGPHLLYIDVPNLVLKGEVPWTPCMQVELKNSGTFFIHTPNRVYYLFDLEKKADEWCKAINDVRKRY 569          

Query: 1906 FYGGSTILAPLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMHYDYGGYTLDISGPVMIQTQKLTSLAFNLLDGHRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHIPCSK-------------KQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDYQRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQ--FRPI 3252
            FY GS IL PL+  +GI  D++NF++      G+  + R      +++   R ++ A  GI IV FCFG  +K+LL  +  SY I+ F P      +V  + M ++  +H YR       Y+LD++GP+M+  +K T +AFNL DG   +Q    +++  ES  +K++P  ++F  + F F  VL GP    N Y +YI   D+KH+   K             K   S   L+++  L   Y         V +  Y  +   +   +  I+ F +R  YYFAW   +A    +G G+ G DK G   W    N     +E   SLK  +DGWNI T  WLR++ YERAP   RT+  +T+SA WHG   GYY+ F T  LFT  A+T R+ +R  F+        Y + + I + +AL Y    F  +         K  YF  H++A   +  L   F+P+
Sbjct:    7 FYDGSKILEPLAETIGIEADRVNFVLSLFACFGISYVYRKTCSLKQVNRQVRTVVPAVVGIGIVFFCFGRAIKHLLANALGSYAIMYFAPPTQVHKIVLLFSMGYLFFIHCYRWAI-LESYSLDVTGPIMVAVEKATMMAFNLKDGKAKDQSKLTEEQKRES--LKEIPSLLEFMSFMFNFQTVLTGP---ANNYYDYIKFLDEKHLVADKHGKLPSPTGAAMKKFYQSLFFLAIVVTLGGKYKVED-----VGTQPYFALPFFQWFFWWFITIFFIRCAYYFAWVFADAICNMSGFGFSGYDKEGNAEWKLCTNVLPYQVEMAQSLKETLDGWNIQTGFWLRKVGYERAPKSIRTVATYTLSAVWHGVSIGYYMAFFTCGLFTVAAQTFRRSMRWRFLDDHNKKFAYDIFSFIISKIALAYATYSFVTMHMYPAYDVLKRVYFIPHIVAFAVIFALPKFFKPL 459          

Query: 1906 FYGGSTILAPLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMHYDYGGYTLDISGPVMIQTQKLTSLAFNLLDGHRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHIPCSK-------------KQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDYQRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQ--FRPI 3252
            FY GS IL PL+  +GI  D++NF++      G+  + R      +++   R ++ A  GI IV FCFG  +K+LL  +  SY I+ F P      +V  + M ++  +H YR       Y+LD++GP+M+  +K T +AFNL DG   +Q    +++  ES  +K++P  ++F  + F F  VL GP    N Y +YI   D+KH+   K             K   S   L+++  L   Y         V +  Y  +   +   +  I+ F +R  YYFAW   +A    +G G+ G DK G   W    N     +E   SLK  +DGWNI T  WLR++ YERAP   RT+  +T+SA WHG   GYY+ F T  LFT  A+T R+ +R  F+        Y + + I + +AL Y    F  +         K  YF  H++A   +  L   F+P+
Sbjct:    7 FYDGSKILEPLAETIGIEADRVNFVLSLFACFGISYVYRKTCSLKQVNRQVRTVVPAVVGIGIVFFCFGRAIKHLLANALGSYAIMYFAPPTQVHKIVLLFSMGYLFFIHCYRWAI-LESYSLDVTGPIMVAVEKATMMAFNLKDGKAKDQSKLTEEQKRES--LKEIPSLLEFMSFMFNFQTVLTGP---ANNYYDYIKFLDEKHLVADKHGKLPSPTGAAMKKFYQSLFFLAIVVTLGGKYKVED-----VGTQPYFALPFFQWFFWWFITIFFIRCAYYFAWVFADAICNMSGFGFSGYDKEGNAEWKLCTNVLPYQVEMAQSLKETLDGWNIQTGFWLRKVGYERAPKSIRTVATYTLSAVWHGVSIGYYMAFFTCGLFTVAAQTFRRSMRWRFLDDHNKKFAYDIFSFIISKIALAYATYSFVTMHMYPAYDVLKRVYFIPHIVAFAVIFALPKFFKPL 459          

Query: 1906 FYGGSTILAPLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMHYDYGGYTLDISGPVMIQTQKLTSLAFNLLDGHRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHIPCSKK-------------QLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDYQRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCG-KDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQ--FRPIINDKVNIMNNVFTRKAQYRFQKLK 3324
            FY   T+L P+S  + + +DQ+NF+   LLS GLG   R +F     S +TR  +    G++   FC+G  + +L +    SY++++ +P Q     V  + M ++ ++H YR  Y    Y LD++G +M+   K+T LA  + DG  + +  K      +  AVK++P  + F  Y F F  V+ GP   Y+ +  ++   + KH+P ++K             +  +A+  SV++ +L +Y+    P            ++    + T+ +  + R  YYFAW++ ++    +G GY G  D+  E  WS+  N   + +E G + K +VD WNI T  WLR ++YER     RT+ V+   A WHG   GYY  FLT +LFT  A T R+ +R  F+ + +   +Y +   + +  A+ Y   PFY++ F   L  ++      H +A+F  L L   F P    K+   N   T     R  ++ 
Sbjct:   15 FYDPVTLLRPVSRAISMNLDQLNFVTVLLLSFGLGYWFRVQF--CDASRTTRAAVTTSVGLIFTYFCYGNAIAHLFINGFGSYLLMVSVPPQHVHKSVFAFAMGYLVLIHSYRWMYQ-KTYCLDVTGSMMVAVGKITLLASAITDG--MGRDPKALNSGQKRDAVKEVPSLLDFASYMFNFQTVIVGPMNHYSTWSAFL---ELKHVPKNEKTGKPYDPTSTAMKKFEAAIAFSVVYTILGSYL----PMSLTNDPSINEYNLLIWWLITVAASTVHRLPYYFAWTISDSICNISGFGYDGLADETLEPKWSRTTNVKPLLVEFGQNYKEMVDNWNIWTVAWLRRVVYERVEGPYRTLAVYVTGAAWHGLAVGYYFSFLTSALFTLSAATFRRCMRHRFLGNSMHKLMYDIFGMLVSKFAIGYIHWPFYVMHFWPSLFMYRKLLMIPHFIALFIYLYLPQIFSPQPKSKITGPNASATSVNTDRISEIS 491          

Query:   82 SDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRI-NHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETR-DNSYSDEPNSDSEE----HSEIEVKRTSSPDN--------------------SREILY------LMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSD-GKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWD--------------------------EIPVGFEEAW--KFNIKKEFQEMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYG 1479
            +DF FG+ IG GS+S V +A +I + + YA K+ +K  I ++R  + +  E+EV+ ++ N   FV L+ TFQD   LYF+++YA +G++L ++ R+  FD+ CT+ Y+AE++LA E++H  NVVHRD+KPENILL E+MH  I DFGSA ++   +   ++   + Q  S          R +N   D  + DSEE      E + +   SP +                    S E+L         D WALGCIVYQM++G  PF      ++Y IF++I +   +FP GFD  A+D V KLL ++P +RLG   + G + +++AHP F  ID++ +  Q PP + P + P V  + D                          E+ VG   A   K +  K   ++  A+K + L+ Q+K + +H F    +I+K+G + KR+GLF RKRM LLT GP L Y+DP  M  K E+  +     E KN K+F++ T  RTY+L+DP   A  W ++IE++    YG
Sbjct:  163 NDFIFGRYIGEGSYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDYIKREREVMHQMTNVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDEDFYDRDSEELDDGDDEQQQEEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGLPPFR---GSNDYVIFKEILDCAVDFPQGFDKDAEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQTLRQQTPPPIYPYL-PGVSQDEDFRSSYTVPGDLEPGLDERQISRLLSAELGVGSSVAMPVKRSTAKNSFDLNDAEKLQRLE-QQKTDKWHVFADGEVILKKGFVNKRKGLFARKRMLLLTTGPRLIYIDPVQMIKKGEIPWSPDLRAEYKNFKIFFVHTPNRTYYLDDPEGYAIHWSEAIENMRKLAYG 684          

Query:   82 SDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRI-NHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETR-DNSYSDEPNSDSEE----HSEIEVKRTSSPDN--------------------SREILY------LMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSD-GKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWD--------------------------EIPVGFEEAW--KFNIKKEFQEMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYG 1479
            +DF FG+ IG GS+S V +A +I + + YA K+ +K  I ++R  + +  E+EV+ ++ N   FV L+ TFQD   LYF+++YA +G++L ++ R+  FD+ CT+ Y+AE++LA E++H  NVVHRD+KPENILL E+MH  I DFGSA ++   +   ++   + Q  S          R +N   D  + DSEE      E + +   SP +                    S E+L         D WALGCIVYQM++G  PF      ++Y IF++I +   +FP GFD  A+D V KLL ++P +RLG   + G + +++AHP F  ID++ +  Q PP + P + P V  + D                          E+ VG   A   K +  K   ++  A+K + L+ Q+K + +H F    +I+K+G + KR+GLF RKRM LLT GP L Y+DP  M  K E+  +     E KN K+F++ T  RTY+L+DP   A  W ++IE++    YG
Sbjct:  163 NDFIFGRYIGEGSYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDYIKREREVMHQMTNVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDEDFYDRDSEELDDGDDEQQQEEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGLPPFR---GSNDYVIFKEILDCAVDFPQGFDKDAEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQTLRQQTPPPIYPYL-PGVSQDEDFRSSYTVPGDLEPGLDERQISRLLSAELGVGSSVAMPVKRSTAKNSFDLNDAEKLQRLE-QQKTDKWHVFADGEVILKKGFVNKRKGLFARKRMLLLTTGPRLIYIDPVQMIKKGEIPWSPDLRAEYKNFKIFFVHTPNRTYYLDDPEGYAIHWSEAIENMRKLAYG 684          

Query:   82 SDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRI-NHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETR-DNSYSDEPNSDSEE----HSEIEVKRTSSPDN--------------------SREILY------LMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSD-GKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWD--------------------------EIPVGFEEAW--KFNIKKEFQEMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYG 1479
            +DF FG+ IG GS+S V +A +I + + YA K+ +K  I ++R  + +  E+EV+ ++ N   FV L+ TFQD   LYF+++YA +G++L ++ R+  FD+ CT+ Y+AE++LA E++H  NVVHRD+KPENILL E+MH  I DFGSA ++   +   ++   + Q  S          R +N   D  + DSEE      E + +   SP +                    S E+L         D WALGCIVYQM++G  PF      ++Y IF++I +   +FP GFD  A+D V KLL ++P +RLG   + G + +++AHP F  ID++ +  Q PP + P + P V  + D                          E+ VG   A   K +  K   ++  A+K + L+ Q+K + +H F    +I+K+G + KR+GLF RKRM LLT GP L Y+DP  M  K E+  +     E KN K+F++ T  RTY+L+DP   A  W ++IE++    YG
Sbjct:  163 NDFIFGRYIGEGSYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDYIKREREVMHQMTNVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDEDFYDRDSEELDDGDDEQQQEEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGLPPFR---GSNDYVIFKEILDCAVDFPQGFDKDAEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQTLRQQTPPPIYPYL-PGVSQDEDFRSSYTVPGDLEPGLDERQISRLLSAELGVGSSVAMPVKRSTAKNSFDLNDAEKLQRLE-QQKTDKWHVFADGEVILKKGFVNKRKGLFARKRMLLLTTGPRLIYIDPVQMIKKGEIPWSPDLRAEYKNFKIFFVHTPNRTYYLDDPEGYAIHWSEAIENMRKLAYG 684          

Query:   82 SDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRI-NHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETR-DNSYSDEPNSDSEE----HSEIEVKRTSSPDN--------------------SREILY------LMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSD-GKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWD--------------------------EIPVGFEEAW--KFNIKKEFQEMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYG 1479
            +DF FG+ IG GS+S V +A +I + + YA K+ +K  I ++R  + +  E+EV+ ++ N   FV L+ TFQD   LYF+++YA +G++L ++ R+  FD+ CT+ Y+AE++LA E++H  NVVHRD+KPENILL E+MH  I DFGSA ++   +   ++   + Q  S          R +N   D  + DSEE      E + +   SP +                    S E+L         D WALGCIVYQM++G  PF      ++Y IF++I +   +FP GFD  A+D V KLL ++P +RLG   + G + +++AHP F  ID++ +  Q PP + P + P V  + D                          E+ VG   A   K +  K   ++  A+K + L+ Q+K + +H F    +I+K+G + KR+GLF RKRM LLT GP L Y+DP  M  K E+  +     E KN K+F++ T  RTY+L+DP   A  W ++IE++    YG
Sbjct:  227 NDFIFGRYIGEGSYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDYIKREREVMHQMTNVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDEDFYDRDSEELDDGDDEQQQEEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGLPPFR---GSNDYVIFKEILDCAVDFPQGFDKDAEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQTLRQQTPPPIYPYL-PGVSQDEDFRSSYTVPGDLEPGLDERQISRLLSAELGVGSSVAMPVKRSTAKNSFDLNDAEKLQRLE-QQKTDKWHVFADGEVILKKGFVNKRKGLFARKRMLLLTTGPRLIYIDPVQMIKKGEIPWSPDLRAEYKNFKIFFVHTPNRTYYLDDPEGYAIHWSEAIENMRKLAYG 748          

Query:   82 SDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRI-NHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETR-DNSYSDEPNSDSEE----HSEIEVKRTSSPDN--------------------SREILY------LMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSD-GKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWD--------------------------EIPVGFEEAW--KFNIKKEFQEMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYG 1479
            +DF FG+ IG GS+S V +A +I + + YA K+ +K  I ++R  + +  E+EV+ ++ N   FV L+ TFQD   LYF+++YA +G++L ++ R+  FD+ CT+ Y+AE++LA E++H  NVVHRD+KPENILL E+MH  I DFGSA ++   +   ++   + Q  S          R +N   D  + DSEE      E + +   SP +                    S E+L         D WALGCIVYQM++G  PF      ++Y IF++I +   +FP GFD  A+D V KLL ++P +RLG   + G + +++AHP F  ID++ +  Q PP + P + P V  + D                          E+ VG   A   K +  K   ++  A+K + L+ Q+K + +H F    +I+K+G + KR+GLF RKRM LLT GP L Y+DP  M  K E+  +     E KN K+F++ T  RTY+L+DP   A  W ++IE++    YG
Sbjct:  244 NDFIFGRYIGEGSYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDYIKREREVMHQMTNVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDEDFYDRDSEELDDGDDEQQQEEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGLPPFR---GSNDYVIFKEILDCAVDFPQGFDKDAEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQTLRQQTPPPIYPYL-PGVSQDEDFRSSYTVPGDLEPGLDERQISRLLSAELGVGSSVAMPVKRSTAKNSFDLNDAEKLQRLE-QQKTDKWHVFADGEVILKKGFVNKRKGLFARKRMLLLTTGPRLIYIDPVQMIKKGEIPWSPDLRAEYKNFKIFFVHTPNRTYYLDDPEGYAIHWSEAIENMRKLAYG 765          

Query:   76 KASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSA--IIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEIPVGFEEAWKF--------------NIKKEFQEME-----------KADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYY 1476
            K  DF FGK +G GSFSTV++AKE++T K YA KI++K  I K+   + V+ EK++L  I+H FFV L +TFQD ++LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLH + ++HRD+KPENILL E+MHI+I DFG+A  +  D    + +SF GTAQ+VSPE+L                      +E    ++S            D WA+GCI+YQ+++G  PF    + +EY IFQKI  L+YEFP  F   AKD V +LL L+P +RLG    G    LK H  F ++ +E +  Q PP L P +  + +       N++++   F                    NI++   +++             +K+ LLQ Q   NP+H+FV N LI K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DPS  AD+W + I+ +    Y
Sbjct:   62 KKEDFSFGKILGEGSFSTVVLAKELATGKEYAMKILEKNHIRKENKAHYVIREKDILSCIDHPFFVKLFFTFQDSQKLYFALSYAKNGELLRYIRKIGSFDETCTRFYTAEIVCALEYLHTVGIIHRDLKPENILLCEDMHIQITDFGTAKQLSSDSAQTRANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWAMGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYEFPEKFFPKAKDLVQRLLSLDPRKRLGCEEMGGFGPLKGHMFFETVSWENLPLQTPPKLTPYLPAMAEDDEDYYGNYEDLLSQFSSLQVVPSSSAQIVPPRPCSNIEQYIHDLDSNSFELDLQFSSEEKRLLLQKQTSGNPWHQFVENNLIYKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSPELRPEAKNFKTFFVHTPNRTYYLMDPSGNADKWCKKIQEVWGTVY 524          

Query:   76 KASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSA--IIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEIPVGFEEAWKF--------------NIKKEFQEME-----------KADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYY 1476
            K  DF FGK +G GSFSTV++AKE++T K YA KI++K  I K+   + V+ EK++L  I+H FFV L +TFQD ++LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLH + ++HRD+KPENILL E+MHI+I DFG+A  +  D    + +SF GTAQ+VSPE+L                      +E    ++S            D WA+GCI+YQ+++G  PF    + +EY IFQKI  L+YEFP  F   AKD V +LL L+P +RLG    G    LK H  F ++ +E +  Q PP L P +  + +       N++++   F                    NI++   +++             +K+ LLQ Q   NP+H+FV N LI K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DPS  AD+W + I+ +    Y
Sbjct:   73 KKEDFSFGKILGEGSFSTVVLAKELATGKEYAMKILEKNHIRKENKAHYVIREKDILSCIDHPFFVKLFFTFQDSQKLYFALSYAKNGELLRYIRKIGSFDETCTRFYTAEIVCALEYLHTVGIIHRDLKPENILLCEDMHIQITDFGTAKQLSSDSAQTRANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWAMGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYEFPEKFFPKAKDLVQRLLSLDPRKRLGCEEMGGFGPLKGHMFFETVSWENLPLQTPPKLTPYLPAMAEDDEDYYGNYEDLLSQFSSLQVVPSSSAQIVPPRPCSNIEQYIHDLDSNSFELDLQFSSEEKRLLLQKQTSGNPWHQFVENNLIYKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSPELRPEAKNFKTFFVHTPNRTYYLMDPSGNADKWCKKIQEVWGTVY 535          

Query:   67 RTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSA--IIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDE------------------IPVGFEEAW-KFNIKKEFQE-----------ME------KADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYY 1476
            R  +  DF+FGK +G GSFSTV++AKE +T K YA KI++K  I K+     V  E++++  ++H FFV L +TFQD E+LYF +SYA+ GELL ++ ++  FD TCT+FYSAEI+ ALEYLH   ++HRD+KPENILLSE MHI+I DFG+A  +  D    + +SF GTAQ+VSPE+L                      +E    ++S            D WALGCI+YQ+++G  PF    + +EY IFQKI  L+YEFP  F   AKD V +LL L+  +R+G    G +  LK+HP F S+ ++ +  Q PP L   +  + +       N+D+                  +PV  E +   +N      +           ME        +K+ LL  Q   NP+H+FV N LI+K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DPS  AD+W + I+ +  + Y
Sbjct:   53 RKKRPEDFRFGKILGEGSFSTVVLAKEHTTGKEYAIKILEKRHIMKENKAQYVKRERDIMSHLDHPFFVKLYFTFQDEEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYSAEIVCALEYLHQKGIIHRDLKPENILLSEEMHIQITDFGTAKQLSSDSKQARANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYEFPEKFFPKAKDLVEQLLSLDSCKRIGCDEMGGYGPLKSHPFFESVGWDDLHLQTPPKLTAYLPAMSEDDEDCYGNYDDLLSQFSCMQVAQPGPAPLVPVTGETSQPTYNPSPSVDQFIHIHELDSNSMELDLQYSNEEKRILLDKQSAANPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSPELRPEAKNFKTFFVHTPNRTYYLMDPSGNADKWCKKIQEVWRKIY 529          

Query: 1915 GSTILAPLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMH-YDYGGYTLDISGPVMIQTQKLTSLAFNLLDG-----HRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKH----------------IPCSKKQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDY-QRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQFRP 3249
            GS +L P+S +  +P+DQ+NF+VC L ++      R    PSK S   R ++    GI   LFCFG+   + LLQS ++Y I++    +          + +++   + R++ +DYG Y+ D +GP+M+ TQK+TS+AF + DG      ++NQG KL        A++++P  +++F Y   F G+LAGP   YN+Y  +I G   +H                 P    ++   L    I  L+   V   FP       D+        ++++  +S    R KYYF W++ +A   + G G+ G D +G   W  + N   + IE  +S KV +D WNI T  WL+ + YER P +  T   F +SA WHG YPGYYL FLT  + T  AR VR ++RP F+ SP    +Y V+T   T +A+ Y   PF LL     L F++ +YF  H+  +   + L  +P
Sbjct:   11 GSNLLQPISEMTNLPLDQVNFVVCQLCALLTAVWFRLYLHPSKTSPFVRHVVATLLGIYFALFCFGWYALHFLLQSGITYGIMILTGVEHMHKYCLVVALGYLSFCQITRVYVFDYGMYSADFTGPMMVITQKITSVAFEIHDGMARKVEQLNQGQKLL-------AIRRMPSLLEYFSYNCNFMGILAGPTCSYNDYIAFIEGTPYRHRDLEPKGKVNGKSRLNDPSPNTEVIRKLSTCFISLLVFLSVCKVFPVERNVDDDFIATSPFYVQVVYLYLSMLTTRPKYYFVWTLADAINNAAGFGFNGYDSDGSPRWDLLSNIRILNIELATSFKVFLDNWNIQTAHWLKRVCYERCP-YNPTAATFLLSAMWHGAYPGYYLTFLTGIVITLAARAVRHNVRPHFLGSPSHKFVYDVITWAATQIAICYTVVPFVLLSVGPSLKFYRSWYFCLHIGCILLAIALPVKP 470          

Query: 1915 GSTILAPLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMH-YDYGGYTLDISGPVMIQTQKLTSLAFNLLDGH-RINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITG--YDDKHIPCSKKQ-------------------LSSALCLSVIHGLLTAYVAPQFPY-IFVCSTDYQRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQFR 3246
            GST+L P+S ++ +P+DQ+NF+VC L ++      R    PSK S   R ++    G  + LFCFG+   + L+QS ++Y +++F   +          M +++  H+ R++ +DYG Y+ D +GP+M+ TQK+TSLAF + DG  +  + +K  Q+     AV+K+P  +++  Y   F G+LAGP   YN+Y ++I G  Y+ KH+  + K+                    + ALCL++   + TA    +  +  F+ S  +       +++F  IS   +R KYYF W++ +A   + G G+ G + +G   W ++ N   + IE  +S K+ +D WNI T  WL+ + YER P +  T   F +SA WHG YPGYYL F+T    T  AR VR ++R  F+ S     +Y V+T   T +A+ Y   PF LL     + F++ +Y   H++ +   L L  +
Sbjct:    9 GSTLLQPISKMIDLPLDQVNFVVCQLFALVTAFWFRLYLHPSKTSPFIRHVVATLLGFYLALFCFGWYALHFLVQSGLAYGVMIFTSVEHMHKYCFVVTMGYLSFCHVTRVYVFDYGMYSADFTGPMMVITQKITSLAFEIHDGLVKREEHLKPSQK---YLAVRKMPSLLEYLSYNCNFMGILAGPTCSYNDYIDFIEGRGYESKHLETNGKENGKFKQIEPSPKRDVIQKVCTCALCLTIYLVIHTACPTERVTHESFMASNPFYI-----QVLFLYISMLSLRPKYYFVWTLADAINNAAGFGFNGYNTDGTPKWDRISNLRILNIEFATSFKMFLDNWNIQTALWLKRVCYERCP-YNPTAATFLLSAMWHGVYPGYYLTFVTGIAVTMAARAVRHNVRQHFLGSSTLKLIYDVITWFSTQIAICYTVVPFVLLAVGPSIKFYRSWYCCIHLICVLLALVLPVK 467          

Query:   67 RTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIII--DKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEIPVGF---------------------EEAWKFNIKKEFQEME-----------KADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYY 1476
            R  +  DFKFGK +G GSFSTV++AKE++T + YA KI+ K  I K+  V  V  EK+V+ R++H FFV L +TFQDPE+LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLH   ++HRD+KPENILLSE+MHI+I DFG+A +   D   ++ +SF GTAQ+VSPE+L                      +E    ++S            D WALGCIVYQ+++G  PF    + +EY IFQKI  L+Y+FP  F   AKD V KLLV++P +RLG    G +  LKAHP F ++ ++ +  Q PP L   +  + +       N+D++   F                      +    NI++   +++           +A+K+ LL+ Q   N +H+FV N LI+K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DPS  A +W + I+ +    Y
Sbjct:   28 RKKRPQDFKFGKILGEGSFSTVVLAKELTTGREYAVKILQKRHIMKENKVQYVNREKDVMSRLDHPFFVKLYFTFQDPEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVCALEYLHENGIIHRDLKPENILLSEDMHIQITDFGTAKVSSSDSKQVRANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIVYQLVAGLPPFR---AGNEYLIFQKIIKLEYDFPEKFFPKAKDLVEKLLVIDPTKRLGCEELGGYGPLKAHPFFETVTWQDLHLQTPPKLTAYLPAMSEDDEDCYGNYDDLLSQFGCMQVATSASSPSLAPLEPLLSQRCGSNIEQYIHDLDNNSFELDLQFSEAEKRLLLEKQVGGNQWHQFVENNLIVKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCKKIQEVWRHRY 500          

Query:   58 ENQRTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEIPVGF---------------------EEAWKFNIKKEFQEME-----------KADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESI 1461
            +  R  +  DFKFGK +G GSFSTV++AKE++T + YA KI+ K  I K+  V  V  EK+V+ R++H FFV L +TFQDPE+LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLH   ++HRD+KPENILLSE+MHI+I DFG+A        K SS               S   + N+YS                +         I+   D WALGCIVYQ+++G  PF    + +EY IFQKI  L+Y+FP  F   AKD V KLLV++P +RLG    G +  LKAHP F ++ ++ +  Q PP L   +  + +       N+D++   F                      +    NI++   +++           +A+K+ LL+ Q   N +H+FV N LI+K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DPS  A +W + I+ +
Sbjct:   52 QQPRKKRPQDFKFGKILGEGSFSTVVLAKELTTGREYAVKILQKRHIMKENKVQYVNREKDVMSRLDHPFFVKLYFTFQDPEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVCALEYLHENGIIHRDLKPENILLSEDMHIQITDFGTA--------KVSS---------------SDSKQGNTYS----------------KLFYQTLKYVIMCFSDLWALGCIVYQLVAGLPPF---RAGNEYLIFQKIIKLEYDFPEKFFPKAKDLVEKLLVIDPTKRLGCEELGGYGPLKAHPFFETVTWQDLHLQTPPKLTAYLPAMSEDDEDCYGNYDDLLSQFGCMQVATSASSPSLAPLEPLLSQRCGSNIEQYIHDLDNNSFELDLQFSEAEKRLLLEKQVGGNQWHQFVENNLIVKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCKKIQEV 515          

Query:   67 RTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEIPVGF---------------------EEAWKFNIKKEFQEME-----------KADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESI 1461
            R  +  DFKFGK +G GSFSTV++AKE++T + YA KI+ K  I K+  V  V  EK+V+ R++H FFV L +TFQDPE+LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLH   ++HRD+KPENILLSE+MHI+I DFG+A        K SS               S   + N+YS                +         I+   D WALGCIVYQ+++G  PF    + +EY IFQKI  L+Y+FP  F   AKD V KLLV++P +RLG    G +  LKAHP F ++ ++ +  Q PP L   +  + +       N+D++   F                      +    NI++   +++           +A+K+ LL+ Q   N +H+FV N LI+K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DPS  A +W + I+ +
Sbjct:   76 RKKRPQDFKFGKILGEGSFSTVVLAKELTTGREYAVKILQKRHIMKENKVQYVNREKDVMSRLDHPFFVKLYFTFQDPEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVCALEYLHENGIIHRDLKPENILLSEDMHIQITDFGTA--------KVSS---------------SDSKQGNTYS----------------KLFYQTLKYVIMCFSDLWALGCIVYQLVAGLPPF---RAGNEYLIFQKIIKLEYDFPEKFFPKAKDLVEKLLVIDPTKRLGCEELGGYGPLKAHPFFETVTWQDLHLQTPPKLTAYLPAMSEDDEDCYGNYDDLLSQFGCMQVATSASSPSLAPLEPLLSQRCGSNIEQYIHDLDNNSFELDLQFSEAEKRLLLEKQVGGNQWHQFVENNLIVKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCKKIQEV 536          

Query:   67 RTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEIPVGF---------------------EEAWKFNIKKEFQEME-----------KADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESI 1461
            R  +  DFKFGK +G GSFSTV++AKE++T + YA KI+ K  I K+  V  V  EK+V+ R++H FFV L +TFQDPE+LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLH   ++HRD+KPENILLSE+MHI+I DFG+A        K SS               S   + N+YS                +         I+   D WALGCIVYQ+++G  PF    + +EY IFQKI  L+Y+FP  F   AKD V KLLV++P +RLG    G +  LKAHP F ++ ++ +  Q PP L   +  + +       N+D++   F                      +    NI++   +++           +A+K+ LL+ Q   N +H+FV N LI+K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DPS  A +W + I+ +
Sbjct:   81 RKKRPQDFKFGKILGEGSFSTVVLAKELTTGREYAVKILQKRHIMKENKVQYVNREKDVMSRLDHPFFVKLYFTFQDPEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVCALEYLHENGIIHRDLKPENILLSEDMHIQITDFGTA--------KVSS---------------SDSKQGNTYS----------------KLFYQTLKYVIMCFSDLWALGCIVYQLVAGLPPF---RAGNEYLIFQKIIKLEYDFPEKFFPKAKDLVEKLLVIDPTKRLGCEELGGYGPLKAHPFFETVTWQDLHLQTPPKLTAYLPAMSEDDEDCYGNYDDLLSQFGCMQVATSASSPSLAPLEPLLSQRCGSNIEQYIHDLDNNSFELDLQFSEAEKRLLLEKQVGGNQWHQFVENNLIVKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCKKIQEV 541          

Query:   67 RTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEIPVGF---------------------EEAWKFNIKKEFQEME-----------KADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESI 1461
            R  +  DFKFGK +G GSFSTV++AKE++T + YA KI+ K  I K+  V  V  EK+V+ R++H FFV L +TFQDPE+LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLH   ++HRD+KPENILLSE+MHI+I DFG+A        K SS               S   + N+YS                +         I+   D WALGCIVYQ+++G  PF    + +EY IFQKI  L+Y+FP  F   AKD V KLLV++P +RLG    G +  LKAHP F ++ ++ +  Q PP L   +  + +       N+D++   F                      +    NI++   +++           +A+K+ LL+ Q   N +H+FV N LI+K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DPS  A +W + I+ +
Sbjct:   75 RKKRPQDFKFGKILGEGSFSTVVLAKELTTGREYAVKILQKRHIMKENKVQYVNREKDVMSRLDHPFFVKLYFTFQDPEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVCALEYLHENGIIHRDLKPENILLSEDMHIQITDFGTA--------KVSS---------------SDSKQGNTYS----------------KLFYQTLKYVIMCFSDLWALGCIVYQLVAGLPPF---RAGNEYLIFQKIIKLEYDFPEKFFPKAKDLVEKLLVIDPTKRLGCEELGGYGPLKAHPFFETVTWQDLHLQTPPKLTAYLPAMSEDDEDCYGNYDDLLSQFGCMQVATSASSPSLAPLEPLLSQRCGSNIEQYIHDLDNNSFELDLQFSEAEKRLLLEKQVGGNQWHQFVENNLIVKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCKKIQEV 535          

Query:   67 RTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIII--DKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEI--PVGFEEAWKF-------------------NIKKEFQEME-----------KADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYGS 1482
            R  +  DFKFGK +G GSFSTV++A+E++T++ YA KI++K  I K+  V  V  E++V+ R++H FFV L +TFQD E+LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLHG  ++HRD+KPENILL+E+MHI+I DFG+A ++  +    + +SF GTAQ+VSPE+L                      +E    ++S            D WALGCI+YQ+++G  PF    + +EY IFQKI  L+Y FP  F   A+D V KLLVL+  +RLG      +  LKAHP F +I +E +  Q PP L   +  + +       N+D +    GF +                       NI++   +++           + +K+ LL+ Q   NP+H+FV N LI+K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DPS  A +W + I+ +  + Y S
Sbjct:   51 RKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYHFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFETITWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGFMQVSSSSSSHSLSTVETSLPQRSGSNIEQYIHDLDTNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQQYQS 525          

Query:   67 RTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIII--DKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEI--PVGFEEAWKF-------------------NIKKEFQEME-----------KADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYGS 1482
            R  +  DFKFGK +G GSFSTV++A+E++T++ YA KI++K  I K+  V  V  E++V+ R++H FFV L +TFQD E+LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLHG  ++HRD+KPENILL+E+MHI+I DFG+A ++  +    + +SF GTAQ+VSPE+L                      +E    ++S            D WALGCI+YQ+++G  PF    + +EY IFQKI  L+Y FP  F   A+D V KLLVL+  +RLG      +  LKAHP F +I +E +  Q PP L   +  + +       N+D +    GF +                       NI++   +++           + +K+ LL+ Q   NP+H+FV N LI+K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DPS  A +W + I+ +  + Y S
Sbjct:   78 RKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYHFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFETITWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGFMQVSSSSSSHSLSTVETSLPQRSGSNIEQYIHDLDTNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQQYQS 552          

Query:   67 RTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIII--DKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEI--PVGFEEAWKF-------------------NIKKEFQEME-----------KADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVT 1389
            R  +  DFKFGK +G GSFSTV++A+E++T++ YA KI++K  I K+  V  V  E++V+ R++H FFV L +TFQD E+LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLHG  ++HRD+KPENILL+E+MHI+I DFG+A ++  +    + +SF GTAQ+VSPE+L                      +E    ++S            D WALGCI+YQ+++G  PF    + +EY IFQKI  L+Y FP  F   A+D V KLLVL+  +RLG      +  LKAHP F +I +E +  Q PP L   +  + +       N+D +    GF +                       NI++   +++           + +K+ LL+ Q   NP+H+FV N LI+K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T
Sbjct:   78 RKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYHFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFETITWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGFMQVSSSSSSHSLSTVETSLPQRSGSNIEQYIHDLDTNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHT 521          

Query:   67 RTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIII--DKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWD 1062
            R  +  DFKFGK +G GSFSTV++A+E++T++ YA KI++K  I K+  V  V  E++V+ R++H FFV L +TFQD E+LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLHG  ++HRD+KPENILL+E+MHI+I DFG+A ++  +    + +SF GTAQ+VSPE+L                      +E    ++S            D WALGCI+YQ+++G  PF    + +EY IFQKI  L+Y FP  F   A+D V KLLVL+  +RLG      +  LKAHP F +I +E +  Q PP L   +  + + + D
Sbjct:   78 RKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYHFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFETITWENLHQQTPPKLTAYLPAMSEDDED 374          

Query: 1933 PLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMH-YDYGGYTLDISGPVMIQTQKLTSLAFNLLDGH-RINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYI------------TGYDDKH---IPCSKKQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDYQ-RMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAM 3219
            PLSN + +P+DQ+NF+VC L ++      R     SK S   R ++    G+ +  FCFG+   + L+QS +SY I++    +        + + ++++  + R++ +DYG Y+ D SGP+MI TQK+TSLA+ + DG  R ++ +   QR     AV+++P  +++  YT  F G+LAGP   Y +Y  +I             G D++H    P     ++  L +  +  L    ++   P  +     +Q       +  +  +S    R KYYFAW++ +A   + G G+ G DKNG   W  + N     IE  +S K+ +D WNI T  WL+ + YERA  F  TI  F +SA WHG YPGYYL FLT  L T  AR VR + R  F+  P     Y ++T + T + ++Y   PF LL  +    F+  +Y+  HV ++
Sbjct:   14 PLSNAVQLPIDQVNFVVCQLFALLAAVWFRTYLHSSKTSSFIRHVVATLLGLYLAFFCFGWYALHFLVQSGISYCIMIIAGVESMQQCCFVFALGYLSVCQITRVYIFDYGQYSADFSGPMMIITQKITSLAYEIHDGMFRKDEELTPSQRGL---AVRRMPSLLEYVSYTCNFMGILAGPLCSYKDYIAFIEGRASHVAQPSENGKDEQHGKADPSPNAAVTEKLLVCGLSLLFHLTISNMLPVEYNIDEHFQATASWPTKATYLYVSLLAARPKYYFAWTLADAINNAAGFGFRGYDKNGVARWDLISNLRIQQIEMSTSFKMFLDNWNIQTALWLKRVCYERA-TFSPTIQTFFLSAIWHGVYPGYYLTFLTGVLMTLAARAVRNNFRHYFLEPPQLKLFYDLITWVATQITISYTVVPFVLLSIKPSFTFYSSWYYCLHVCSI 456          

Query:   67 RTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIII--DKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWD---------------------------EIPVGFEEAWKFNIKKEFQEME-----------KADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYGSFKLSPGTCTQ 1512
            R  +  DFKFGK +G GSFSTV++A+E++T++ YA KI++K  I K+  V  V  E++V+ R++H FFV L +TFQD E+LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLHG  ++HRD+KPENILL+E+MHI+I DFG+A ++  D    + +SF GTAQ+VSPE+L                      +E    ++S            D WALGCI+YQ+++G  PF    + +EY IFQKI  L+Y+FP  F   A+D V KLLVL+  +RLG      +  LKAHP F SI +E +  Q PP L   +  + + + D                            +     +    NI++   +++           + +K+ LL+ Q   NP+H+FV N LI+K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DPS  A +W + I+ +  + Y S   SP    Q
Sbjct:   78 RKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPDSKQARANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESITWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSAVDASLPQRSGSNIEQYIHDLDTNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQQYQS---SPDAAVQ 559          

Query:   85 DFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIII--DKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEI---------------------PVGFEEAWKFNIKKEFQEME-----------KADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYGS 1482
            DFKFGK +G GSFSTV++A+E++T++ YA KI++K  I K+  V  V  E++V+ R++H FFV L +TFQD E+LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLHG  ++HRD+KPENILL+E+MHI+I DFG+A ++  +    + +SF GTAQ+VSPE+L                      +E    ++S            D WALGCI+YQ+++G  PF    + +EY IFQKI  L+Y+FP  F   A+D V KLLVL+  +RLG      +  LKAHP F S+ +E +  Q PP L   +  + +       N+D +                       G  +    NI++   +++           + +K+ LL+ Q   NP+H+FV N LI+K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DPS  A +W + I+ +  + Y S
Sbjct:   81 DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQS 549          

Query:   67 RTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIII--DKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEI--PVGFEEAWKF-------------------NIKKEFQEME-----------KADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYGS 1482
            R  +  DFKFGK +G GSFSTV++A+E++T++ YA KI++K  I K+  V  V  E++V+ R++H FFV L +TFQD E+LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLHG  ++HRD+KPENILL+E+MHI+I DFG+A ++  +    + +SF GTAQ+VSPE+L                      +E    ++S            D WALGCI+YQ+++G  PF    + +EY IFQKI  L+Y FP  F   A+D V KLLVL+  +RLG      +  LKAHP F +I +E +  Q PP L   +  + +       N+D +    GF +                       NI++   +++           + +K+ LL+ Q   NP+H+FV N LI+K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DPS  A +W + I+ +  + Y S
Sbjct:   78 RKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYHFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFETITWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGFMQVSSSSSSHSLSTVETSLPQRSGSNIEQYIHDLDTNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQQYQS 552          

Query:   82 SDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRI-NHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETR-DNSYSDEPNSDSEE----HSEIEVKRTSSPDN--------------------SREILY------LMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSD-GKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWD--------------------------EIPVGFEEAW--KFNIKKEFQEMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYG 1479
            +DF FG+ IG GS+S V +A +I + + YA K+ +K  I ++R  + +  E+EV+ ++ N   FV L+ TFQD   LYF+++YA +G++L ++ R+  FD+ CT+ Y+AE++LA E++H  NVVHRD+KPENILL E+MH  I DFGSA ++   +   ++   + Q  S          R +N   D  + DSEE      E + +   SP +                    S E+L         D WALGCIVYQM++G  PF      ++Y IF++I +   +FP GFD  A+D V KLL ++P +RLG   + G + +++AHP F  ID++ +  Q PP + P + P V  + D                          E+ VG   A   K +  K   ++  A+K + L+ Q+K + +H F    +I+K+G + KR+GLF RKRM LLT GP L Y+DP  M  K E+  +     E KN K+F++ T  RTY+L+DP   A  W ++IE++    YG
Sbjct:  244 NDFIFGRYIGEGSYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDYIKREREVMHQMTNVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDEDFYDRDSEELDDGDDEQQQEEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGLPPFR---GSNDYVIFKEILDCAVDFPQGFDKDAEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQTLRQQTPPPIYPYL-PGVSQDEDFRSSYTVPGDLEPGLDERQISRLLSAELGVGSSVAMPVKRSTAKNSFDLNDAEKLQRLE-QQKTDKWHVFADGEVILKKGFVNKRKGLFARKRMLLLTTGPRLIYIDPVQMIKKGEIPWSPDLRAEYKNFKIFFVHTPNRTYYLDDPEGYAIHWSEAIENMRKLAYG 765          

Query:   85 DFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIII--DKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWD 1062
            DFKFGK +G GSFSTV++A+E++T++ YA KI++K  I K+  V  V  E++V+ R++H FFV L +TFQD E+LYF +SYA+ GELL ++ ++  FD TCT+FY+AEI+ ALEYLHG  ++HRD+KPENILL+E+M+I+I DFG+A ++  +    + +SF GTAQ+VSPE+L                      +E    ++S            D WALGCI+YQ+++G  PF    + +EY IFQKI  L+Y+FP  F   A+D V KLLVL+  +RLG      +  LKAHP F S+ +E +  Q PP L   +  + + + D
Sbjct:   54 DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMYIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDED 344          

Query: 2299 QTQKLTSLAFNLLDGHRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHIPCSKKQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDYQRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQFRPIINDKVNIMNNVFTRKAQYR 3309
            QTQKLTSLAFNLLDGHRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHIPCSKKQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDYQRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQFRPIINDKVNIMNNVFTRKAQYR
Sbjct:    1 QTQKLTSLAFNLLDGHRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHIPCSKKQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDYQRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQFRPIINDKVNIMNNVFTRKAQYR 337          

Query: 2299 QTQKLTSLAFNLLDGHRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHIPCSKKQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDYQRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQFRPIINDKVNIMNNVFTRKAQYR 3309
            QTQKLTSLAFNLLDGHRI+QG+KL Q+NHESHAV+KLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHIPCSKKQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDYQRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSL TFCAR+VRKHIRPLF+VSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQFRPIINDKVN MNNVFTRKAQYR
Sbjct:    1 QTQKLTSLAFNLLDGHRIDQGMKLDQKNHESHAVRKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHIPCSKKQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDYQRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLSTFCARSVRKHIRPLFVVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQFRPIINDKVNQMNNVFTRKAQYR 337          

Query:   49 TKAENQRTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWDEIPVGFEEAWKFNIKKEF----QEMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYGS-----FKLSPGTCT 1509
            T   N+   K SDFKFGKEIGHGSFSTV + +EIST+  +A K++DK  + + + V++V++EKEVL+R NH F + L+ TFQD  RL++++ YA  GELLS+LT  +   + CT+FY+AEI++AL+YLH +++VHRD+KPEN+LL++ MHIK+ DFGSA+I++ P++K  +FTGT ++VSPEML        +  S + NS S +             NS+++ YLMDFWA GCI+YQ++SG  PF      HEYE FQKI +L Y F   FD  AKD V KLLV++P ERLG+PS G   +++ H  F  I ++ +  Q+PPLL+PN+EPI    WD++PVGFE+A K+++ +E      E+ + D+ +LL  QE+ NPF+RFVR RLI+KQGIL+KRRGLF+RKRMFLLTEGPHLFYVD + M  K EV+ +    +EV+++K+F+I    +TY+LEDPS  AD+W + I ++  +Y+       F   P T T
Sbjct:    6 TNEINRHIPKPSDFKFGKEIGHGSFSTVYVVQEISTSSEFAMKVVDKQRVWRYKAVDSVLMEKEVLKRTNHVFIIRLHCTFQDSTRLFYLLEYARCGELLSYLTHFTSLSVHCTRFYAAEILMALDYLHSVSIVHRDLKPENVLLTDRMHIKLADFGSAVILNSPNIKAPNFTGTPEYVSPEML--------SRISRQGNSSSND------------GNSQDLTYLMDFWAFGCIIYQLISGFPPFRKSGPAHEYETFQKILSLSYTFASNFDPIAKDLVEKLLVISPSERLGSPSHGGSVSVRQHMFFSEIKWDTLPHQEPPLLVPNLEPIAPEGWDDLPVGFEDAEKYHLSRELSLVASEITEDDRIRLLNTQERHNPFNRFVRGRLILKQGILFKRRGLFSRKRMFLLTEGPHLFYVDMENMTLKGEVAWSSSLTLEVRSNKLFFIHVPNKTYYLEDPSGHADDWVKQIAAVKTQYFSDTPQTLFSNYPSTST 481          

Query:   76 KASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWDEIPVGFEEAWKFNIKKEFQE----MEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYG 1479
            + SDF+FGKEIG GSFS V + +EI++N   A K+++K  + + + V +V +EK VL R+NH F + L+YTFQD  RL+F++ YA  GELL+HL RL+ FDL C++FY+AEI++AL YLH  ++VHRDIKPEN+LL+E MHIK+ DFGSAII++ P +K   FTGT ++VSPEML         S++DE +  S      E           +  YLMD+WA GC++YQ++SGR PF      H Y+IF++I  L Y+F  GFD  A+D V KLLV+NP++RLG+P++G  AA++ HP F  ID++ + +Q  P+LLPN+EPI  S+WD +P GF+E   + +  EF      + + ++ +LL  QE+ NP+HRFVRNRLI+KQG+L+KRRGLF RKRMFLLTEGPHLFYVD DAM  K EV  +    +E+K+DK+F+I    RT++LEDPS KA  W   + ++   YY 
Sbjct:   32 RPSDFRFGKEIGQGSFSNVYVVREIASNAELAMKVVEKQHVVRNKAVESVHMEKAVLTRVNHVFIIRLHYTFQDASRLFFVLEYARGGELLTHLNRLTSFDLPCSRFYAAEILVALNYLHTQSIVHRDIKPENVLLTEAMHIKLADFGSAIILNDPKVKAPGFTGTPEYVSPEMLS------SRSFADESSLSSSHSFSFE-----------DTAYLMDYWAFGCVLYQLISGRPPFRTEKHHHAYDIFEQILGLCYKFLDGFDAVARDLVQKLLVINPMDRLGSPTNGGPAAVQEHPFFSGIDWDSLPNQPAPILLPNLEPIAPSDWDSLPTGFDEGQMYLLSCEFASAVTPIPETERSRLLSAQERQNPYHRFVRNRLILKQGVLFKRRGLFARKRMFLLTEGPHLFYVDMDAMSLKGEVPWSSFLTLELKSDKLFFIRIPNRTFYLEDPSGKAAAWVAQLSAVKQAYYA 486          

Query:   76 KASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHA-ALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWDEIPVGFEEAWKFNIKKEF----QEMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYY 1476
            + SDF+FGKEIG GSFSTV + +E++TN  +A K++DK  + + R V +V++EKEVL+R NH F + L YTFQD  RL++++ YA  G LL +LTRL+ FD+ C +FY+AEI +ALEYLH   +VHRD+KPEN+LL+ENMHIK+ DFGSAII++   +K  SFTGT ++VSPEML  S  +R +   DE N +++     + K   +P +  E  YLMD+WA GC++YQ LSGR PF    + H YE F KI NL Y F  GFD  AKD V +LLV++PL+RLG+P++G    A++ H  F+ ID++ + +Q PP+L PN+EPI  + WD  P GF+E  KF    E      ++   ++ KLL  QE+ NPFHRFVRNRLIIKQGIL+KRRGLF RKRMFLLTEGPHLFYVD D+M  K EV  +    +E K+DK+F+I+   RTY+LEDPS  A +W + I ++   Y+
Sbjct:   16 RPSDFRFGKEIGQGSFSTVYVVREVATNAEFAMKVVDKQHVRRNRAVESVIMEKEVLKRTNHIFIIRLYYTFQDESRLFYVLEYARGGALLDYLTRLTSFDIPCARFYAAEIFIALEYLHKQCIVHRDLKPENVLLTENMHIKLADFGSAIILNDSKVKAPSFTGTPEYVSPEML--SPCSRIDEDDDEDNDEAK-----QTKTEPNPYSYEETAYLMDYWAFGCVIYQFLSGRPPFRPERNGHAYETFGKILNLSYSFADGFDPVAKDLVKQLLVIDPLKRLGSPANGNGPRAIQTHEFFQGIDWDTLPNQNPPILHPNVEPIAPAGWDTAPQGFKEIEKFLTSNELGLSASQVTDNERPKLLALQERQNPFHRFVRNRLIIKQGILFKRRGLFARKRMFLLTEGPHLFYVDVDSMNLKGEVLWSSFLTLEQKSDKLFFIIVPNRTYYLEDPSGNASDWVEQISAVHSIYF 480          

Query:   64 QRTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSA--IIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEIPVGF----------EEAWKF-----------NIKKEFQEMEK-----------ADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYGS 1482
            QR  +A DFKFGK +G GSFSTV++AKE+ST K YA KI++K  I K+   + V  E+++L  +++ FFV L +TFQD E+LYF +SYA+ GELL ++ ++  FD TCT+FY+AE++ AL+YLH + ++HRD+KPENILL+E MHI+I DFG+A     D    + +SF GTAQ+VSPE+L                           K+++   +        D WALGCIVYQ+++G  PF    + +EY IFQKI  L+Y+FP  F   AKD V KLL  +  +RLG    G +  L+AHP F  + +E +  Q PP L P +  + +       N+D++   F           +A              NI++   +++             +K  LL+ Q   NP+H+FV N LI+K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DP+  AD W + I+ +    Y S
Sbjct:   58 QRKKRAEDFKFGKILGEGSFSTVVLAKELSTGKEYAIKILEKTHIRKENKAHYVKRERDILSSLDNPFFVKLYFTFQDAEKLYFGLSYAKNGELLRYIRKIGSFDETCTRFYTAELVSALQYLHSVGIIHRDLKPENILLNEEMHIQITDFGTAKQFSSDSTQTRANSFVGTAQYVSPELL--------------------------TKKSACKSS--------DLWALGCIVYQLVAGLPPFR---AANEYLIFQKIIKLEYDFPEKFFPKAKDLVEKLLCSDATKRLGCEEMGGYNPLRAHPFFEGVSWENLHLQTPPKLTPYLPAMAEDDEEYYGNYDDLLSQFTNLEVVQSTSSQALSLPATLVPLRSSSNIEQYIHDLDNNSFELDLQFSSEEKLLLLKKQTNGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSPELRPEPKNFKTFFVHTPHRTYYLMDPNGNADRWCKKIQEVWGTIYHS 533          

Query:   49 TKAENQRTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSA--IIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEIPVGFE---------------------------------------EAWKFNIKKEFQEMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESI 1461
            ++    R  +  DFKFGK +G GSFSTV++AKE ST K YA KI++K  I K+     V  E++V+  ++H FFV L +TFQD E+LYF +SYA+ GELL ++ ++  FD TCT+FYSAEI+ ALEYLH   ++HRD+KPENILLSE MHI+I DFG+A  +  D    + +SF GTAQ+VSPE+L                      +E    ++S            D WALGCI+YQ+++G  PF    + +EY IFQKI  L+YEFP  F   AK+ V +LL+L+P +R+G    G +  LK+HP F SI ++ +  Q PP L P +  + +       N+D++   F                                        ++    +  +F E E   K+ LL  Q   NP+H+FV N LI K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DPS  AD+W + I+ +
Sbjct:   47 SQPAQPRKKRPEDFKFGKILGEGSFSTVVLAKEHSTGKEYAIKILEKRHIMKENKAQYVKRERDVMSILDHPFFVKLYFTFQDEEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYSAEIVCALEYLHQKGIIHRDLKPENILLSEEMHIQITDFGTAKQLSSDSRQARANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYEFPEKFFPKAKNLVEQLLLLDPCKRIGCEEMGGYEPLKSHPFFESISWDDLHLQTPPKLTPYLPAMSEDDEDCYGNYDDLLSQFSSMQVAQPGPTPSADEPSESLLPVCNPAPSVDQFIHIHELDSNSMELDLQFSEEE---KRLLLDKQSAANPWHQFVENNLIFKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSPELRPEAKNFKTFFVHTPNRTYYLMDPSGNADKWCKKIQEV 524          

Query:   49 TKAENQRTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAA--KIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSA--IIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEIPVGFE---------------------------------------EAWKFNIKKEFQEMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESI 1461
            ++    R  +  DFKFGK +G GSFSTV +   ++    Y    KI++K  I K+     V  E++V+  ++H FFV L +TFQD E+LYF +SYA+ GELL ++ ++  FD TCT+FYSAEI+ ALEYLH   ++HRD+KPENILLSE MHI+I DFG+A  +  D    + +SF GTAQ+VSPE+L                      +E    ++S            D WALGCI+YQ+++G  PF    + +EY IFQKI  L+YEFP  F   AK+ V +LL+L+P +R+G    G +  LK+HP F SI ++ +  Q PP L P +  + +       N+D++   F                                        ++    +  +F E E   K+ LL  Q   NP+H+FV N LI K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DPS  AD+W + I+ +
Sbjct:   23 SQPAQPRKKRPEDFKFGKILGEGSFSTVHVLL-VNNVCFYVCLVKILEKRHIMKENKAQYVKRERDVMSILDHPFFVKLYFTFQDEEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYSAEIVCALEYLHQKGIIHRDLKPENILLSEEMHIQITDFGTAKQLSSDSRQARANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYEFPEKFFPKAKNLVEQLLLLDPCKRIGCEEMGGYEPLKSHPFFESISWDDLHLQTPPKLTPYLPAMSEDDEDCYGNYDDLLSQFSSMQVAQPGPTPSADEPSESLLPVCNPAPSVDQFIHIHELDSNSMELDLQFSEEE---KRLLLDKQSAANPWHQFVENNLIFKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSPELRPEAKNFKTFFVHTPNRTYYLMDPSGNADKWCKKIQEV 501          

Query: 1915 GSTILAPLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMH-YDYGGYTLDISGPVMIQTQKLTSLAFNLLDGHRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHIPCS-------KKQLSS-ALCLSVIHGLLTAYVAPQFPYIFVC-------STDYQRMHMT---RRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQFRP 3249
            GS++L P+S ++ +P+DQ+NF+VC L ++      R    PSK S   R ++    G+   LFCFG+   + L+QS ++Y I++    +          +A++    + R++ +DYG Y+ D +GP+M+ TQK+TS+AF + DG    +  +L Q + +  A++++P  +++F Y   F G+LAGP   Y +Y  +I G   +H           K +L+  +  + V+  L T +++    ++ VC       +TD   +  T    ++++  +S    R KYYF W++ +A   + G G+ G D +G+  W  + N   M IE  +S KV +D WNI T  WL+ + YER P +  T   F +SA WHG YPGYYL FLT  + T  AR VR ++RP F+ SP    +Y V+T   T +A+ Y   PF LL     L F++ +YF  H+  +   + L  +P
Sbjct:   11 GSSLLQPISEIINLPLDQVNFVVCQLCALLTAFWFRLYLHPSKTSPFVRHVVATLLGLYFALFCFGWYALHFLMQSGITYGIMIIAGVEHMHKYCLVVALAYLGFCQITRVYVFDYGMYSADFTGPMMVITQKITSIAFEIHDGMARKED-QLTQ-SQKLLAIRRMPSLLEYFSYNCNFMGILAGPTCSYKDYIAFIEGKPFRHRELENNGKLQGKTRLNDPSPNMEVVRKLGTCFLS-LLVFLSVCKVFPVERNTDDDFIATTPIYAKVVYLYLSMLTTRPKYYFVWTLADAINNAAGFGFNGYDSDGKPQWDLISNLRIMNIELATSFKVFLDNWNIQTAHWLKRVCYERCP-YNPTAATFLLSAMWHGAYPGYYLTFLTGIVVTLAARAVRHNVRPYFLGSPTHKFVYDVITWASTQIAICYTVVPFVLLSVGPSLKFYRSWYFCLHIGCVLLAIALPVKP 470          

Query: 1915 GSTILAPLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMH-YDYGGYTLDISGPVMIQTQKLTSLAFNLLDG-HRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYI--TGYDDKHI--------------PCSKKQL-----SSALCLSVIHGLLTAY-VAP-----QFPYIFVCSTDYQRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQFR 3246
            GST+L P+S ++ +P+DQ+NF+VC L ++      R    PSK S   R ++    G  + LFCFG+   + L+QS ++Y I++F   +          + ++ +  + R++ +DYG Y+ D +GP+M+ TQK+TSLAF + DG  +  + +K  Q+     AV+K+P  +++  Y   F G+LAGP   YN+Y  +I  TGY  KH+              P  K+ +     + ALCL V    LT Y + P     Q PY       +       R+++  +S   +R KYYF W++ +A   + G G+ G +K+G   W  + N   + IE  +S K  +D WNI T  WL+ + YER P +  T   F +SA WHG YPGYYL F++    T  AR VR ++R  F+ S     +Y V+T   T +A+ Y   PF +L     L F+  +YF  H+  +  +L L  +
Sbjct:   10 GSTVLQPISEMIDLPLDQVNFVVCQLFALFTACWFRLYLHPSKTSPFIRHVVATLLGFYLALFCFGWYALHFLVQSGLTYGIMIFTGLEHMHRYSFVVALGYLMLCQITRVYVFDYGMYSADFTGPMMVITQKITSLAFEIHDGLTKKEEHLKPSQK---YLAVRKMPSLLEYLSYNCNFLGILAGPTCSYNDYIAFIEGTGYQHKHLESNGKENGKCKQSDPSPKRDVILKMSTCALCLLV---YLTFYRICPVDRVIQDPY-------FTSQPFYLRVLYIYLSMLCLRPKYYFVWTLADAINNAAGFGFNGYNKDGTPKWDMISNLRILDIEFATSFKSFLDNWNIQTALWLKRVCYERCP-YHPTAATFLLSAMWHGVYPGYYLTFVSGIGVTLAARAVRHNVRQHFLGSSTHKLIYDVITWASTQIAICYTVVPFVVLAVGPSLRFYWSWYFCLHLACVILILALPVK 468          

Query:   55 AENQRTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIII--DKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEIPVGF------------------------------------EEAWKFNIKKEFQ-EMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYY 1476
            A + R  +  DFKFGK +G GSFSTV++AKE++T K YA KI++K  I K++ V  V  EKEVL R+NH FFV L +TFQD E+LYF +SYA+ GE+L ++ +   FD  CT+FYSA+I+ +LE+LH + ++HRD+KPENILL+E+MHI+I DFG+A I+  +    + +SF GTAQ+VSPE+L                      +E    ++S            D WALGCI+YQ+++G  PF    + +EY IFQKI  L+YEFP  F   AKD V KLLV +P++RLG    G +  LK+HP F  I ++ +  Q PP L   +  + +       N+D++  GF                                    E   + +++ +F   + + D++ LL  Q + NP+H FV N LI K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +     E KN K F++ T  RTY+L DP   A  W + IE +    Y
Sbjct:   13 AAHPRKKRPEDFKFGKILGEGSFSTVVLAKEVATGKEYAIKILEKRHIIKEKKVPYVNREKEVLSRLNHPFFVKLFFTFQDEEKLYFGLSYAKNGEMLKYIRKHRSFDENCTRFYSAQIVSSLEHLHSLGIIHRDLKPENILLNEDMHIQITDFGTAKILSDNSKHARANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIIYQLVAGLPPFR---APNEYLIFQKIIKLEYEFPEKFFPKAKDLVEKLLVSDPMQRLGCDECGGYPPLKSHPFFSEISWDDLHLQTPPKLTAYLPAMTEDDEECYGNYDDLLSGFGNMQVEETQPIPIPSVARVPSSGGCSSGGSYRDYILENEDEHSLELDFNLALSQDDRKLLLNKQARANPWHPFVENNLIFKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSRELRPEAKNFKTFFVHTPNRTYYLMDPRCNAHTWCKKIEEVWKRTY 494          

Query:   82 SDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHG-INVVHRDIKPENILLSENMHIKICDFG--SAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWD 1062
            ++F + K +G G+F  V++ +E +T ++YA KI+ K  I  +  V   + E  VL+   H F   L Y+FQ  +RL F++ Y   GEL  HL+R   F    T+FY AEI+ AL+YLH   NVV+RD+K EN++L ++ HIKI DFG     I D   +K  +F GT ++++PE+L       DN Y                               +D+W LG ++Y+M+ GR+PF+  +  HE ++F+ I      FP    + A+  +S LL  +P +RLG   D     ++ H  F  I ++ +  +K   + P  +P V S  D
Sbjct:  148 NNFDYLKLLGKGTFGKVILVREKATGQYYAMKILKKEVIVAKDEVAHTLTENRVLQTTKHPFLTLLKYSFQTHDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHTEKNVVYRDLKLENLMLDKDGHIKIADFGLCKEGITDGATMK--TFCGTPEYLAPEVL------EDNDYG----------------------------RAVDWWGLGVVMYEMMCGRLPFY--NQDHE-KLFELILMEDIRFPRTLSNDARALLSGLLKKDPKQRLGGGVDDAKEIMR-HSFFAGIIWQDVYDRK---MTPPFKPQVASETD 434          

Query:   73 TKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVL-RRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPP 1017
             K SDF F   +G GSF  V++AK  S    YA K++ K  I +++    +M E+ VL + + H F V L+Y+FQ  ++LYF++ Y   GEL  HL R   F  +  QFY+AEI  A+ YLH +N+V+RD+KPENILL    HI + DFG       P     +F GT ++++PE+L   K   D +                                +D+W LGC++Y+ML G  PF+ ++ +  YE    I +   +      + A   +  LL  +P +RLG  SD     +K H  F +I++  + +++ P
Sbjct:   87 AKPSDFDFLTVLGKGSFGKVLLAKHKSDGIFYAVKVMKKSIILQKKEEKHIMAERNVLVKNVRHPFLVGLHYSFQSADKLYFVMDYVNGGELFFHLQRQGSFPESRAQFYAAEIGSAIGYLHSLNIVYRDLKPENILLDYQGHIVLTDFGLCKEGIDPHSTTCTFCGTPEYLAPEVL--KKHPYDRT--------------------------------VDWWCLGCVLYEMLYGLPPFYSKNLKQMYE---SILHQPLQLRPCTTNAAISVLEGLLHKDPHQRLGATSD--ILEIKNHVFFSTINWNDLDAKRIP 363          

Query: 1966 QINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTY-WCMAFMAIVHLYRMH-YDYGGYTLDISGPVMIQTQKLTSLAFNLLDGH-RINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDK---------------HIPCSKKQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDY-QRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRE 2898
            Q+NF++C LL++ +    R    P   S   R  +    G    +FCFG+   +  +Q   SY I++ + ++ + H  T+ + M ++ +  + R++ +  G ++ D SGP+M+ TQK+TSLAF + DG  + +Q + ++QR   S   ++LP  ++F  +   F  +LAGP   + +Y  +I G   K               H P     ++S L + ++  +    ++  FP        +     +  R+ +  +S    R KYYFAW++ +A   + G G+ G DKNG + W  V N +   IE+ +S K+ +D WNI T  WL+ 
Sbjct:    1 QVNFVMCQLLALAMAFFFRLYLHPRAASERVRHGLATLLGSYFAIFCFGWYATHFFVQVIASYAIIVLVDTR-NVHKYTFIFAMGYLTVCQISRVYIFTSGVFSTDFSGPMMVMTQKITSLAFEIHDGMIKEDQDLTVEQRRLAS---RRLPTLLQFLSFNLNFLSILAGPSSSFKDYTAFIEGSHYKGWERSGACGRENGPLHEPSPAAAVTSKLLMVLLSLVFYLTLSKAFPVSLNADEAFIASAPLHARLCYLYVSCQGGRPKYYFAWTLADAINNAAGFGFNGYDKNGRSKWDLVSNLNIWNIETATSFKMFIDNWNIQTALWLKR 326          

Query:  154 TNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEML---GFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQK--PPLLLPNIEPIVQSNWDE 1065
              +H + K   +  + K + V   + EK +L+ I+  F V L Y+F+D   LY ++ Y   GE+ SHL R+  F    ++FY+A+I+LA EYLH +++++RD+KPEN+L+ +  +I++ DFG A  +     +  +  GT ++++PE++   G++K                                      +D+WALG ++Y+M +G  PF    +    +I++KI + K  FP  F    KD +  LL ++  +R GN  +G +  +K H  F + D+  I  +K   P +     P   SN+D+
Sbjct:    3 VGQHVSLKATKRTKVVKLKQVEHTLNEKRILQAISFPFLVRLEYSFKDNSNLYMVLEYVPGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKGYNKA-------------------------------------VDWWALGVLIYEMAAGYPPF---FADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVN-DIKNHKWFSTTDWIAIYQRKVEAPFIPKCKGPGDASNFDD 267          

Query:   85 DFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQ-FFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIID-------KPD----LKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFE--IIGSQKPPLLLP 1029
            DFKFG  IG G++STVM+A  I T K YAAK+++K ++ +Q+ V  V IEK  L+++N+    V L  TFQD   LYF++ YA  G+ LS + +    D TC ++Y+A+II A++YLH   ++HRDIKPENILL   M IK+ DFG+A +++       KP+     +  SF GTA++VSPE+L       ++S++D                           Y  D WA GCI++QM++G+ PF    + +EY  FQK+  ++Y F  GF    +D V K+LV N   RL        + +K H  F+ ++F+   + S+ PP + P
Sbjct:  178 DFKFGSVIGDGAYSTVMLATSIDTKKRYAAKVLNKEYLIRQKKVKYVSIEKTALQKLNNSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSLMKKYGSLDETCARYYAAQIIDAIDYLHSNGIIHRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSFVGTAEYVSPELL-------NDSFTD---------------------------YRCDIWAFGCILFQMIAGKPPF---KATNEYLTFQKVMKVQYAFTPGFPLIIRDLVKKILVKNLDRRLT------ISQIKEHHFFKDLNFKDGSVWSKTPPEIKP 463          

Query:   85 DFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINH-QFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIII-----DKPDLKP--------SSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFE--IIGSQKPPLLLP 1029
            DFKFG+++G GS+S+V++A    + K YA K++ K ++ +Q+ V  V +EK  L+++N  +    L +TFQD   LYF++ YA  G+ L  + +    + TC ++Y+++II A++ LH I ++HRDIKPENILL +NM +K+ DFG+A I+     +  D KP         SF GTA++VSPE+L       +++Y+D                      SR      D WA GCI+YQML+G+ PF    + +EY  FQK+  ++Y F  GF    KD V KLLV +P +RL          +KAH  F  ++FE   +    PP + P
Sbjct:  124 DFKFGEQLGDGSYSSVVLATARDSGKKYAVKVLSKEYLIRQKKVKYVTVEKLALQKLNGTKGIFKLFFTFQDEASLYFLLEYAPHGDFLGLIKKYGSLNETCARYYASQIIDAVDSLHNIGIIHRDIKPENILLDKNMKVKLTDFGTAKILPEEPSNTADGKPYFDLYAKSKSFVGTAEYVSPELL-------NDNYTD----------------------SR-----CDIWAFGCILYQMLAGKPPFK---AANEYLTFQKVMKIQYAFTAGFPQIVKDLVKKLLVRDPNDRL------TIKQIKAHLFFHEVNFEDGSVWDDNPPEIQP 411          

Query:   85 DFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEM---LGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLG-NPSDGKHAALKAHPLFRSIDFE--IIGSQKPPLLLPNIEPIVQSNWDE 1065
            DF   K IG GSF  VM  ++  T K YA K I K +I  +  V   + E+ VL R++  F V L ++FQ PE+LYF++++   GEL  HL +   FDL+  +FY+AE++ AL+ LH ++VV+RD+KPENILL    HI +CDFG   +  K D K  +F GT ++++PE+   LG++K                                      +D+W LG ++Y+ML+G  P+   +     ++++KI      FP GFD  AKD +  LL  +P  RLG N +D     ++ HP F  + ++  ++    PP        +  SN+DE
Sbjct:  346 DFDLLKVIGKGSFGKVMQVRKKDTQKVYALKAIRKSYIVSKSEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYFVLAFINGGELFYHLQKEGRFDLSRARFYTAELLCALDNLHKLDVVYRDLKPENILLDYQGHIALCDFGLCKLNMKDDDKTDTFCGTPEYLAPELLLGLGYTKA-------------------------------------VDWWTLGVLLYEMLTGLPPY---YDEDVPKMYKKILQEPLVFPDGFDRDAKDLLIGLLSRDPTRRLGYNGAD----EIRNHPFFSQLSWKRLLMKGYIPPYKPAVSNSMDTSNFDE 634          

Query: 1918 STILAPLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEA----FFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLY-RMHYDYGGYTLDISGPVMIQTQKLTSLAFNLLDGHRINQG-IKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHIPCSKKQL-------------SSALCL-SVIHGL----LTAYVAPQFPYIFVCSTD-YQRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGEN-NWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYER------APLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFI----VSPITLQLYHVLTKIFT-NLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFC 3225
              +L  +    GI    + + +C L S  L  I++ + P  ++      II       FG+L ++  F    + L + +  +Y+I  F  S+   HL   + M  +AI H++ +   +    T+DI+   M+   KLTS A++  DG   ++   K    + +S AV+  P  +KF  Y F++  +L GP   Y ++  ++     + +P SKK +             +  L L  V+ GL    L+      FP  +V   D +       RI +  +  F+ R KYY AW++ E   +  GLGY G D   +   W +V+N D   +E+  + + +++ WN++T +WL+  +Y R       P F  T+  F  SAFWHG  PGYYL F T +L+  C +  R++ RP+F+    V+P+  +  + L  I+   LA  Y   PF +L+ +  L+ W   YF+ H++  F 
Sbjct:    6 DAVLTKIITNYGIDSFTLRYAICLLGSFPLNAILK-RIPEKRIGLKCCFIISMSMFYLFGVLNLVSGF----RTLFISTMFTYLISRFYRSKFMPHLNFMFVMGHLAINHIHAQFLNEQTQTTVDITSSQMVLAMKLTSFAWSYYDGSCTSESDFKDLTEHQKSRAVRGHPPLLKFLAYAFFYSTLLTGPSFDYADFDSWLNCEMFRDLPESKKPMRRHHPGERRQIPKNGKLALWKVVQGLAWMILSTLGMKHFPVKYVLDKDGFPTRSFIFRIHYLFLLGFIHRFKYYAAWTISEGSCILCGLGYNGYDSKTQKIRWDRVRNIDIWTVETAQNTREMLEAWNMNTNKWLKYSVYLRVTKKGKKPGFRSTLFTFLTSAFWHGTRPGYYLTFATGALYQTCGKIYRRNFRPIFLREDGVTPLPSKKIYDLVGIYAIKLAFGYMVQPFIILDLKPSLMVWGSVYFYVHIIVAFS 473          

Query:   85 DFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWD 1062
            DF+  + +G GSF  V + +     ++YA K++ K  + + + V     E+ +L  + H F + +  TFQD ++++ I+ Y E GEL S L +   F     +FY+AE+ LALEYLH  ++++RD+KPENILL +N HIKI DFG A  +  PD+   +  GT  +++PE++           S +P + S                       +D+W+ G ++Y+ML+G  PF+  ++   YE   KI N +  FP  F++  KD +S+L+  +  +RLGN  +G    +K HP F+ + +E + S+   +  P   PI Q   D
Sbjct:   86 DFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYV--PDVT-YTLCGTPDYIAPEVV-----------STKPYNKS-----------------------IDWWSFGILIYEMLAGYTPFYDSNTMKTYE---KILNAELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTE-DVKNHPWFKEVVWEKLLSRN--IETPYEPPIQQGQGD 368          

Query:   67 RTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKP---SSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEP 1041
            +  K SDF+FGK +G GS+STV +A+EIST K YA K+++K  I K++ V  V  EKEVL R+NH FFV L +TFQD ++LYF +SYA++GELL ++TRL  FD  CTQFYSAEII ALE+LHG+ ++HRD+KPENILL ENMHIKI DFG+A I++K + K    +SF GTAQ+VSPE+L   +  + +                                  D WALGCI+YQ+LSG  P+    + +EY+IFQKI    Y FP GF +  KD V +LL+L+P +RLG    G  + LK H  +  +D++ +   K P LLP + P
Sbjct:    2 KKKKTSDFRFGKLLGEGSYSTVYVAQEISTGKEYAIKVLEKRHIQKEKKVAQVSREKEVLSRLNHPFFVILYFTFQDRDKLYFGLSYAKKGELLPYITRLGSFDEKCTQFYSAEIISALEHLHGLQIIHRDLKPENILLDENMHIKITDFGTAKILNKDEEKNKGRNSFVGTAQYVSPELLTDKRACKSS----------------------------------DIWALGCIIYQLLSGLTPY---RAGNEYQIFQKIIKNDYSFPSGFPEIPKDLVEQLLILDPTKRLGCEECGGFSELKKHQFYEGVDWDGLPESKAPELLPYLPP 292          

Query: 2020 RHKFPPSKLSGSTRGIIEAFFGILIVLF--CFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMHYDYGGYTLDISGPVMIQTQKLTSLAFNLLDG-HRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITG--YDDKHIPC------------SKKQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDYQRMHMTR---RIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFW 3183
            R    PS++S  TR  +    G+ +     C+ + + + L+         +F  S      V+   M  ++  HLYR    YG Y LD +GP+MI TQK+  +AF++ DG  R    +  +Q+  +   +KK+P  +++FGY F++  +L GP   Y+EY ++ITG  ++ K  P             +KK     L  +++  ++    +P+FP     + D   +  T    R+++  +S    R +YYFA+   EA     GLG+ G D+ G  +W+K+ N +   +E   ++K+L+D WNIST  WLR ++Y+R     RT+  F +SAFWHGFY GYYL F+T  +    AR  R+ +R  F  S +T + Y V+T + T + + Y   PF LL+   GL FW
Sbjct:    3 RKVLHPSRVSSKTRQTVGLLAGLFLSWLKQCWSWFLLHFLMFCVYVLNSGVFSKSYAKNQYVSVVAMGILSAAHLYRQITVYGSYVLDYTGPLMIITQKIIYVAFSVHDGMGRDESNLNAEQKKEK---LKKVPSPLEYFGYVFHYSNILIGPVGTYHEYTDFITGTVFNTKVGPVGTCHTVPWAAFNTKKATVEKLSSAILCVVVFVVASPRFP--VASNADPYFIDNTPFIYRLIYAWLSIVATRMRYYFAFKAGEAINNICGLGFGGYDEEGNPSWNKMSNANITKLELAQNMKMLLDNWNISTAVWLRRIVYDRVTSH-RTLATFLLSAFWHGFYGGYYLTFITCQILVEAARVARRTLREHFQGSKMTSRFYDVITCVVTMVFVTYATVPFVLLDPWKGLRFW 404          

Query:   49 TKAENQRTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDT-AKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQ--KPPLLLPNIEPIVQSNWDEIPVGFEEAWK 1095
            T+ +++RTT   DF+  K +G G+F  V++A++    + YA KI++   + + + V  V  EK +L  I H F V L +T  D   LY ++ YA  GEL ++L     F+     F+ +EI+ A++YLHG ++V+RD+KPENILL  + H+K+ DFG A  +     K  +  GT ++++PE++                  S+ H++                  +D+WALG ++Y+ML G  PF      + + I++KI + K E+P   D+T AKD + KLLV +   RLG+  +G    +K H  F+ ID+ ++  +  KPP+      P    N+D+ P   EE W+
Sbjct:    6 TRKKDKRTT-LQDFELSKTLGTGTFGRVLLARDRRGGEFYALKIMNISEVIRLKQVEHVQNEKNILMSIEHPFIVNLLWTQHDQTFLYMLLEYACGGELFTYLRTAGRFNNGTGLFFGSEIVSAMDYLHGHSIVYRDLKPENILLDRDGHVKLTDFGFAKEVHD---KTWTLCGTPEYLAPEII-----------------QSKGHNKA-----------------VDWWALGILIYEMLVGYPPF---FDDNPFGIYEKILSGKVEWPKHMDNTSAKDLIKKLLVHDRTRRLGSMKNGSE-DVKNHKWFKVIDWNLVLQRKLKPPINPKISHPGDTRNFDDYP---EEDWR 312          

Query:   61 NQRTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVL-RRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFG-SAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDF-EIIGSQKPPLLLPNI 1035
            N    K SDF F K IG GSF  V ++K    +K YA K+++K  I K+     +M E+ VL + + H F V L+Y+FQ  ++LYF++ Y   GEL  HL R   F  +  +FY+AEI  A+ YLHG+ +++RD+KPENILL    HI + DFG     ID+     S+F GT ++++PE+L   K+  D S                                +D+W LG ++Y+M+ G  PF   +SR   E++  I +           +A+  +  LL  +  +RLG+  +G    ++ H  FRSI++ +++     P   PN+
Sbjct:   65 NNPKAKPSDFLFLKVIGKGSFGKVFLSKNKQEDKFYAIKVLNKSAIRKRNEAKHIMAERNVLVQNVTHPFLVGLHYSFQTKDKLYFVLDYVNGGELFFHLQRERYFPESRARFYAAEIASAIGYLHGLQIIYRDLKPENILLDSKGHIVLTDFGLCKEGIDRSGTT-STFCGTPEYLAPEVL--RKQDYDKS--------------------------------VDWWCLGAVLYEMMYGLPPF---YSRDTAEMYDNILHKPLRLRTNISQSARHILEGLLQKDKTKRLGS-GEGDFEDIRTHSFFRSINWQQLVARGIEPPYNPNV 353          

Query:   67 RTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLR-RINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWD 1062
            R     DF F K +G GSF  V++A+   T++ YA KI+ K  + +   V   MIE+ VL     H F   L+ +FQ  ERL+F++ Y   G+L+  + +   FD   ++FY+AE++LAL++LH   V++RD+K +N+LL  + HIK+ DFG       P    ++F GT  +++PE+L      ++  Y                             + +D+WALG ++Y+M++G+ PF    + +E ++F+ I +    +PV     A   +   +  N L+RLG       ++++ H  FR I+FE + +++   + P  +P ++S  D
Sbjct:  376 RKMTLKDFTFIKVLGKGSFGKVLLAERKGTDEVYAIKILKKESVLQDDDVECTMIERRVLALSAGHPFLTSLHSSFQTVERLFFVMEYVNGGDLMFQIQKSRKFDENRSRFYAAEVVLALQFLHQNGVIYRDLKLDNVLLDADGHIKLADFGMCKENMAPGKTTTTFCGTPDYIAPEIL------QEQPYG----------------------------FSVDWWALGVLMYEMMAGQPPF---EAENEEDLFESILHDDVLYPVWLSREAVSILKGFMTKNYLKRLGCTPTSTESSIREHAFFRLINFEKLEARQ---INPPFKPKIRSRTD 668          

Query:   67 RTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSA--IIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEIPVGFE-----------------------------------EAWKFNIKKEFQEMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYY 1476
            R  K  DFKFGK +G GSFSTV++A+E +T K +A KI++K  I K+  V  V  E++++  ++H FFV L +TFQD E+LYF +SYA+ GELL ++ ++  FD TCT+FYSAEI+ ALEYLH   ++HRD+KPENILLSE+MHI+I DFG+A  +  D    + +SF GTAQ+VSPE+L                      +E    ++S            D WALGCI+YQ+++G  PF    + +EY IFQKI  L+YEFP  F   AKD V +LL L+P +R+G    G +  LK HP F +I +  +  Q PP L P +  + +       N+D++   F                                    ++  F +  +F E E   K+ LL  Q   NP+H+FV N LI+K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +L    E KN K F++ T  RTY+L DPS  AD W + I+ +  + Y
Sbjct:   58 RKKKPEDFKFGKILGEGSFSTVVLAREHATGKEFAIKILEKRHIMKENKVQYVKRERDLMSSLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYSAEIVCALEYLHIKGIIHRDLKPENILLSEDMHIQITDFGTAKQLSSDSKQARANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYEFPEKFFPKAKDLVEQLLSLDPSKRIGCEEMGGYEPLKQHPFFDTISWCDLHLQTPPKLTPYLPAMSEDDEDCYGNYDDLLSQFSNMQVAQSSSSQSLSPHDSTPPQRSSSNIEQYIHDLDSNSFELDLQFTEEE---KRLLLDKQTIGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNRVLKGEIPWSLELRPEAKNFKTFFVHTPNRTYYLMDPSGNADRWCKKIQEVWRKIY 530          

Query:   67 RTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSA--IIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQ------SNWDEIPVGFE-----------------------------------EAWKFNIKKEFQEMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYY 1476
            R  K  DFKFGK +G GSFSTV++A+E +T K +A KI++K  I K+  V  V  E++++  ++H FFV L +TFQD E+LYF +SYA+ GELL ++ ++  FD TCT+FYSAEI+ ALEYLH   ++HRD+KPENILLSE+MHI+I DFG+A  +  D    + +SF GTAQ+VSPE+L                      +E    ++S            D WALGCI+YQ+++G  PF    + +EY IFQKI  L+YEFP  F   AKD V +LL L+P +R+G    G +  LK HP F +I +  +  Q PP L P +  + +       N+D++   F                                    ++  F +  +F E E   K+ LL  Q   NP+H+FV N LI+K G + KR+GLF R+R  LLTEGPHL+YVDP     K E+  +L    E KN K F++ T  RTY+L DPS  AD W + I+ +  + Y
Sbjct:   88 RKKKPEDFKFGKILGEGSFSTVVLAREHATGKEFAIKILEKRHIMKENKVQYVKRERDLMSSLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYSAEIVCALEYLHIKGIIHRDLKPENILLSEDMHIQITDFGTAKQLSSDSKQARANSFVGTAQYVSPELL----------------------TEKSACKSS------------DLWALGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYEFPEKFFPKAKDLVEQLLSLDPSKRIGCEEMGGYEPLKQHPFFDTISWCDLHLQTPPKLTPYLPAMSEDDEDCYGNYDDLLSQFSNMQVAQSSSSQSLSPHDSTPPQRSSSNIEQYIHDLDSNSFELDLQFTEEE---KRLLLDKQTIGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNRVLKGEIPWSLELRPEAKNFKTFFVHTPNRTYYLMDPSGNADRWCKKIQEVWRKIY 560          

Query: 1915 GSTILAPLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMH-YDYGGYTLDISGPVMIQTQKLTSLAFNLLDGHRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITG--YDDKH---------------IPCSKKQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDY--QRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFF 3201
            GST+L PLS ++ +P+DQ+NF+ C L ++ +    R    PSK S   R ++    G  + LFCFG+   + L+QS +SY +++F   +          + ++ +  + R++ +DYG Y+ D +GP+M+ TQK+TS+AF + DG  + +       N +  A+ ++P  +++  Y   F G+LAGP   Y +Y  +I G  Y  +H                P  K  + S LC   I   +   +    P  +    DY  +   +  ++++  ++   +R KYYF W++ +A   + G G+ G +K+G   W  + N   + IE  +S K+ +D WNI T  WL+ + YER P+   T   F +SA WHG YPGYYL F+T    T  AR VR +IRP F+VS     +Y V+T   T +A++Y   PF LL   S L F+  +YFF
Sbjct:   11 GSTLLQPLSEIINLPLDQVNFVACQLFALLMAMWFRIYLHPSKTSPFIRHVVATLLGFYLALFCFGWYSLHFLVQSGLSYGVMIFAGLEHMHKYCFIVTLGYLIVCQITRVYVFDYGMYSADFTGPMMVITQKITSMAFEIHDG--LAKKESQLTPNQKYLAISRMPSLLEYLSYNCNFMGILAGPTCSYRDYMAFIEGTCYQARHQENANGKENGKFKQSEPSPKNDVISKLCTCAISLAVYLSLYKLLPVEYSID-DYFVKSTPLYLQVIYLYLAMLALRPKYYFVWTLADAINNAAGFGFNGYNKDGSPRWDLISNLRILDIEFATSFKLFLDNWNIQTALWLKRVCYERCPV-NPTAATFLLSAMWHGVYPGYYLTFVTGIGMTMAARAVRHNIRPYFLVSDSHKLVYDVITWACTQVAISYTVVPFVLLAVGSSLKFYSSWYFF 455          

Query: 1915 GSTILAPLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMH-YDYGGYTLDISGPVMIQTQKLTSLAFNLLDGHRINQGIKLQQRNHESH--AVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHIPCSKKQLS------------------SALC--LSVIHGLLTAY--VAPQFPYIFVCSTDY-QRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQFRPIINDKVNI 3273
            GS +L P+S  +G P+DQ+NFI C L  + +    R    PS      R  +    G+  ++FCFG+   ++L      YVI+L               M ++ +  + R+  ++YG  + D SGP+M+ TQ++T+L F L DG       K +Q   E    A+++ P  I++  Y   F  +L GP   Y +Y ++I G   +HI    KQ S                  +A+C  L V  G +  +  V    P  +    D+    H   R+ +   S    R K+YFAW++ +A   + G G+ G D+NG+ +W  V N + + IE+ +S K  +D WNI T  WL+ + Y+RAP   R  L F +SA WHG YPGYY  FLT    T  AR +RK +R  F+ S      Y ++T   T LA+ Y   PF LL     L +++  YF  H+L++  V+TL  +    D  ++
Sbjct:   14 GSKLLLPVSEYLGFPLDQVNFIACQLFGLAVAFWFRLYLKPSHFKPLVRHTVATLLGVTFLVFCFGWYATHILAIVVAIYVIILKADINHVHRYSMVTAMGYLTVCQVSRVFIFNYGVLSTDFSGPLMMVTQRITTLVFQLHDG----MCKKSEQLTSEQKLMAIRERPSLIEYLSYNLNFLSILVGPCSNYRDYIDFIEG---RHISRRLKQHSGSCNGHNGYDKTPDLSPLNAVCRKLLVCCGCMLTFLIVTRSLPIKYNVEPDFVNNAHFLTRLTYAFFSIQAARPKFYFAWTLADAVNNAAGYGFLGIDENGKPSWDLVSNLNIVGIETATSFKTFIDNWNIRTGVWLKTVCYDRAPKH-RLALTFILSALWHGVYPGYYFTFLTAIPITMAARAIRKRVRHHFLNSKGLKLGYDIVTWAATQLAICYTVMPFLLLSIDQTLTYYRSMYFHVHILSILAVITLHGKHKPKDASSV 484          

Query: 1912 GGSTILAPLSNVMGIPVDQ-INFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMH-YDYGGYTLDISGPVMIQTQKLTSLAFNLLDGHRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITG--YDDKH---------------IPCSKKQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDY--QRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFF 3201
            G  T+L P   +    V Q +NF+ C L ++ +    R    PSK S   R ++    G  + LFCFG+   + L+QS +SY +++F   +          + ++ +  + R++ +DYG Y+ D +GP+M+ TQK+TS+AF + DG + N                ++P  +++  Y   F G+LAGP   Y +Y  +I G  Y  +H                P  K  + S LC   I   +   +    P  +    DY  +   +  ++++  ++   +R KYYF W++ +A   + G G+ G +K+G   W  + N   + IE  +S K+ +D WNI T  WL+ + YER P+   T   F +SA WHG YPGYYL F+T    T  AR VR +IRP F+VS     +Y V+T   T +A++Y   PF LL   S L F+  +YFF
Sbjct:    6 GVCTLLLPFIMMTLKKVLQFVNFVACQLFALLMAMWFRIYLHPSKTSPFIRHVVATLLGFYLALFCFGWYSLHFLVQSGLSYGVMIFAGLEHMHKYCFIVTLGYLIVCQITRVYVFDYGMYSADFTGPMMVITQKITSMAFEIHDG-KTNV---------------RMPSLLEYLSYNCNFMGILAGPTCSYRDYMAFIEGTCYQARHQENANGKENGKFKQSEPSPKNDVISKLCTCAISLAVYLSLYKLLPVEYSID-DYFVKSTPLYLQVIYLYLAMLALRPKYYFVWTLADAINNAAGFGFNGYNKDGSPRWDLISNLRILDIEFATSFKLFLDNWNIQTALWLKRVCYERCPV-NPTAATFLLSAMWHGVYPGYYLTFVTGIGMTMAARAVRHNIRPYFLVSDSHKLVYDVITWACTQVAISYTVVPFVLLAVGSSLKFYSSWYFF 438          

Query:   46 MTKAENQRTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWDEIPVGFEEAWKFNIKKEFQEMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYGSFKLSPGTCTQTP 1518
            MTKAENQRTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWDEIPVGFEEAWKFNIKKEFQEMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYGSFKLSPGTCTQTP
Sbjct:    1 MTKAENQRTTKASDFKFGKEIGHGSFSTVMIAKEISTNKHYAAKIIDKVFISKQRMVNTVMIEKEVLRRINHQFFVCLNYTFQDPERLYFIISYAERGELLSHLTRLSCFDLTCTQFYSAEIILALEYLHGINVVHRDIKPENILLSENMHIKICDFGSAIIIDKPDLKPSSFTGTAQFVSPEMLGFSKETRDNSYSDEPNSDSEEHSEIEVKRTSSPDNSREILYLMDFWALGCIVYQMLSGRMPFHVRHSRHEYEIFQKIRNLKYEFPVGFDDTAKDFVSKLLVLNPLERLGNPSDGKHAALKAHPLFRSIDFEIIGSQKPPLLLPNIEPIVQSNWDEIPVGFEEAWKFNIKKEFQEMEKADKQKLLQNQEKLNPFHRFVRNRLIIKQGILYKRRGLFTRKRMFLLTEGPHLFYVDPDAMQFKKEVSLNLITGIEVKNDKVFYIVTKRRTYFLEDPSAKADEWRQSIESICVEYYGSFKLSPGTCTQTP 491          

Query: 1897 MSQFYGGSTILAPLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMHYDYGGYTLDISGPVMIQTQKLTSLAFNLLDGHRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHIPCSKKQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDYQRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQFRPIINDKVNIMNNVFTRKAQYRFQKLKIHLQKKLR 3348
            MSQFYGGSTILAPLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMHYDYGGYTLDISGPVMIQTQKLTSLAFNLLDGHRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHIPCSKKQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDYQRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQFRPIINDKVNIMNNVFTRKAQYRFQKLKIHLQKKLR
Sbjct:    1 MSQFYGGSTILAPLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMHYDYGGYTLDISGPVMIQTQKLTSLAFNLLDGHRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHIPCSKKQLSSALCLSVIHGLLTAYVAPQFPYIFVCSTDYQRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQFRPIINDKVNIMNNVFTRKAQYRFQKLKIHLQKKLR 484          

Query: 1897 MSQFYGGSTILAPLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMHYDYGGYTLDISGPVMIQTQKLTSLAFNLLDGHRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHIPCSK------KQLSSAL------------CLSVIHGLLTAYVAPQFPYIFVCSTDYQRMHM-TRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHV 3210
            MS FY GS I  P+S+ +G+ VDQ NF+ C L++ G G I        K+S + R IIE   G+ + +FCFG Q+ +LL QS   Y+++  + ++ + + +  + + F+++ HL RM+YDYGGYT+DI+GP+MIQTQKL+SLAFNL DG RI +   L++  H  HA+ K P  ++FF Y FYFHG++ GPFVF  +Y  +I G  ++ +   K      K  S+ L            CL  + GLLT +V P F   +  + +Y +  M  + IM T++S FLVRQKYYFAWS+     + +GLG+ G  +  +  +  VKN+DF  IE G+S K ++D WN+ T  WLRE +Y+R P    T+ VF  S+ WHG+YPGYYL F++ +LFT  +R  RK+IRPL   + + L  Y VLT +   LALNY   PF  LE Q     W   +F  HV
Sbjct:    1 MSNFYSGSKIFQPVSDAVGLTVDQFNFMFCQLVASGFGFIFSRYLNTDKISPTFRHIIELVCGVSLTIFCFGSQIWHLLGQSISVYIMMNAMSTKSARYFILGFVLLFLSVAHLARMYYDYGGYTMDITGPLMIQTQKLSSLAFNLHDGQRIKKNEPLRRDYHRKHALLKYPTLLEFFSYMFYFHGIMVGPFVFLADYLRFIEGRQEEVLDNEKEKEYFRKNKSTILAGWPEIGFYVKSCL--VFGLLTIFVQPHFDPDYFKTDEYLQSGMFYKYIMLTIVS-FLVRQKYYFAWSIGSMSNIFSGLGFSGFSEERKPIYDVVKNFDFFKIELGTSTKSIIDNWNVGTIYWLRECVYDRIPRAYGTLAVFVCSSIWHGYYPGYYLCFMSLALFTEASRAGRKYIRPLVHKASLNLP-YDVLTSLLGMLALNYCAIPFTQLEVQLTFYIWSKMFFIVHV 453          

Query: 1897 MSQFYGGSTILAPLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMHYDYGGYTLDISGPVMIQTQKLTSLAFNLLDGHRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDK---------HIPCSKKQLSSA-------LCLSVIHGLLTAYVAPQFPYIFVCSTDYQRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDKNGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVSPITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHV 3210
            MS F+ GS IL P S  +G+ +DQ NF+ C + + G+G +       +K++ + + I E   GIL+ LFCFG Q+ YLL QS   YV++  L  + + + +  + + F+++ H+ RM+YDYG YTLDI+GP+MIQTQKL+SLAFNL+DG R+    KL++  H+ HA+   P  ++FF YTFYFHG++ GPFVF  +Y  +I G  D+         H   +K Q+ SA       L   V + LL  ++ P F   F+ S ++ +    +R +   I+ FLVRQKYY AW+M     L  GLG+ G D+  +  +  VKN+ F   E G+S K ++D WN+ T  WLRE +Y+R P    TI VFT SA WHG+YPGYYL F + +L T  AR  R+  R  F  + + L  Y + T   +   LN+   PF LL+ + G + WK  Y  G V
Sbjct:    1 MSNFHSGSKILLPFSEAVGLKIDQFNFLFCQISACGIGYLFSRYLSRAKINPNYKHISEIILGILLTLFCFGLQIWYLLAQSISVYVMMNVLSVRKARYCILIFVLFFLSVAHIGRMYYDYGSYTLDITGPLMIQTQKLSSLAFNLMDGQRVKNKEKLRKDYHQVHAINHYPTVLEFFSYTFYFHGLMVGPFVFLGDYLRFIEGRQDELLINEDDKNHFKRNKFQILSAWPEISFHLFSLVCYSLLFFFIEPYFKPEFLLSDEFYQNGFFKRYLLMTITMFLVRQKYYIAWTMGSITNLFAGLGFSGFDEKQQPKYHIVKNFHFSRTEFGTSAKTMIDHWNVGTAIWLRECVYDRVPHSIGTITVFTCSAIWHGYYPGYYLAFASVALMTNAARCGRRLFRTYFHNAGLKLP-YDITTATMSMFCLNFSIIPFALLDIRKGFMVWKSLYILGPV 453          

Query: 1897 MSQFYGGSTILAPLSNVMGIPVDQINFIVCSLLSIGLGQIMRHKFPPSKLSGSTRGIIEAFFGILIVLFCFGYQVKYLLLQSTVSYVILLFLPSQISAHLVTYWCMAFMAIVHLYRMHYDYGGYTLDISGPVMIQTQKLTSLAFNLLDGHRINQGIKLQQRNHESHAVKKLPDAIKFFGYTFYFHGVLAGPFVFYNEYKEYITGYDDKHIPCSKKQ----------------LSSALCLSVIHGLLTAYVAPQFPYIFVCSTDYQRMHMTRRIMFTMISFFLVRQKYYFAWSMVEAGALSTGLGYCGKDK-NGENNWSKVKNYDFMAIESGSSLKVLVDGWNISTTRWLRELIYERAPLFCRTILVFTVSAFWHGFYPGYYLMFLTFSLFTFCARTVRKHIRPLFIVS---PITLQLYHVLTKIFTNLALNYGQGPFYLLEFQSGLLFWKPYYFFGHVLAMFCVLTLQFRPIINDKVN 3270
            MS+FY G     PLS+  GI VDQ NF+ C   +  +G+  + K+    +S   R       G  + LFCFG+Q+ +L +   +SY I+ FLP Q S ++V  + M+++A+ HL R ++DYGGYTLDI+GP+M+  Q+L+ LAFNL DG +I +  KL   +   HAV + P  ++FF Y   F  ++ GPF+FY++Y  +I G + ++   SK++                      + +I G L  +V P F   F  + ++ +     +++F +I   L+RQ+YYFAWS+  A  L +GLG+ G +K +G+  +  + N+D   IE   ++K ++DGWN    +WLRE IY RAP    T  VF  SA WHGFYPGYYL F+T  +F   +R  R++IRP F+V+     T + Y VLT + +  A+NY   PF LL     + FW+ +YF GH+     ++ ++F P I  +++
Sbjct:    1 MSKFYAGVRFFEPLSSKFGIHVDQFNFVFCMFAACLMGRQFQTKYSIKNISAEQRHRFAFLGGFTLALFCFGHQIMHLFIPPIISYCIMYFLPYQHSRYIVLLFAMSYLAVTHLARQYWDYGGYTLDITGPLMVLVQRLSILAFNLYDGDQIKKKRKLDFDDAIKHAVLEHPTPLQFFSYVINFQTIMIGPFIFYSDYLRFIEGREIEYAETSKEKEYFVVHRTSILSPEDVTKKYFIIMLICGGLHLFVFPFFQPTFYLTPEFGQYSFINKVIFMLIVSPLLRQQYYFAWSLTSACCLCSGLGFSGFNKISGKPEYKLIDNFDMRNIEMAKNMKAIIDGWNKPANQWLRECIYNRAPKKFATPAVFICSAIWHGFYPGYYLFFVTAGIFLEISRMARRYIRPYFLVNFGDGQTSKFYDVLTTLISMFAINYMSVPFVLLGLSKSIQFWRQFYFCGHLAVPALLILIRFLPKIRTRIH 478