Phosphodiesterase

Overview
NamePhosphodiesterase
Smed IDSMED30025517
Length (bp)185
Neoblast Clusters

Zeng et. al., 2018



 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30025517

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 11

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parapharyngeal regionSMED30025517h1SMcG0000039 SmedASXL_012915SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
parapharyngeal regionSMED30025517h1SMcG0000039 SmedASXL_001253SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
pharynxSMED30025517h1SMcG0000039 dd_Smed_v4_15950_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30025517h1SMcG0000039 dd_Smed_v4_15950_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30025517h1SMcG0000039 dd_Smed_v4_15950_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30025517h1SMcG0000039 dd_Smed_v4_15950_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
pharynxSMED30025517h1SMcG0000039 dd_Smed_v4_35318_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
reproductive organSMED30025517h1SMcG0000039 Contig14302uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30025517h1SMcG0000039 Contig14302newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30025517h1SMcG0000039 Contig13923newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30025517h1SMcG0000039 Contig13923uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE6B (phosphodiesterase 6B [Source:HGNC Symbol;Acc:HGNC:8786])

HSP 1 Score: 58.5362 bits (140), Expect = 2.579e-12
Identity = 26/60 (43.33%), Postives = 41/60 (68.33%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + +++  EFW QGD E+++  Q PI +MDR+   ELP+
Sbjct:   70 MAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPK 129
[Close]
BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE10A (phosphodiesterase 10A [Source:HGNC Symbol;Acc:HGNC:8772])

HSP 1 Score: 60.8474 bits (146), Expect = 2.625e-12
Identity = 28/59 (47.46%), Postives = 36/59 (61.02%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDLCS+ K W +       I  EFW +GDE K +G  PI +MDRD K E+P+
Sbjct:  932 IGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQ 990
[Close]
BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE6C (phosphodiesterase 6C [Source:HGNC Symbol;Acc:HGNC:8787])

HSP 1 Score: 58.5362 bits (140), Expect = 1.550e-11
Identity = 26/60 (43.33%), Postives = 42/60 (70.00%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + +++  EFW QGD E+++  Q PI +MDR+ + ELP+
Sbjct:  715 MAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPK 774
[Close]
BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE10A (phosphodiesterase 10A [Source:HGNC Symbol;Acc:HGNC:8772])

HSP 1 Score: 58.151 bits (139), Expect = 1.939e-11
Identity = 28/59 (47.46%), Postives = 36/59 (61.02%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDLCS+ K W +       I  EFW +GDE K +G  PI +MDRD K E+P+
Sbjct:  683 IGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQ 741
[Close]
BLAST of Phosphodiesterase vs. Ensembl Human
Match: PDE6B (phosphodiesterase 6B [Source:HGNC Symbol;Acc:HGNC:8786])

HSP 1 Score: 58.151 bits (139), Expect = 1.964e-11
Identity = 26/60 (43.33%), Postives = 41/60 (68.33%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + +++  EFW QGD E+++  Q PI +MDR+   ELP+
Sbjct:  431 MAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPK 490
[Close]
BLAST of Phosphodiesterase vs. Ensembl Celegans
Match: pde-5 (Probable 3',5'-cyclic phosphodiesterase pde-5 [Source:UniProtKB/Swiss-Prot;Acc:P91119])

HSP 1 Score: 55.0694 bits (131), Expect = 1.056e-10
Identity = 26/61 (42.62%), Postives = 36/61 (59.02%), Query Frame = 3 
Query:    3 LHMALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            L  A+ MT CDL +  K W++Q   V +I  EF+ QGD E+  G+ PI +MDR     LP+
Sbjct:  604 LTQAVMMTGCDLVASAKPWNIQTETVKVIFEEFYDQGDAERLSGKEPIPMMDRQQAHMLPQ 664
[Close]
BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde11 (gene:FBgn0085370 transcript:FBtr0343831)

HSP 1 Score: 50.0618 bits (118), Expect = 7.136e-9
Identity = 23/58 (39.66%), Postives = 38/58 (65.52%), Query Frame = 3 
Query:   12 ALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKS-IGQLPIRLMDRDYKLELP 182
            A+SMT CDL ++ K W+++  +  ++  EF+ QGD EK  +   PI +M+R+ + ELP
Sbjct:  960 AMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELP 1017
[Close]
BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde11 (gene:FBgn0085370 transcript:FBtr0112545)

HSP 1 Score: 50.0618 bits (118), Expect = 7.136e-9
Identity = 23/58 (39.66%), Postives = 38/58 (65.52%), Query Frame = 3 
Query:   12 ALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKS-IGQLPIRLMDRDYKLELP 182
            A+SMT CDL ++ K W+++  +  ++  EF+ QGD EK  +   PI +M+R+ + ELP
Sbjct:  960 AMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELP 1017
[Close]
BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde11 (gene:FBgn0085370 transcript:FBtr0112544)

HSP 1 Score: 50.0618 bits (118), Expect = 7.138e-9
Identity = 23/58 (39.66%), Postives = 38/58 (65.52%), Query Frame = 3 
Query:   12 ALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKS-IGQLPIRLMDRDYKLELP 182
            A+SMT CDL ++ K W+++  +  ++  EF+ QGD EK  +   PI +M+R+ + ELP
Sbjct: 1004 AMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELP 1061
[Close]
BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde11 (gene:FBgn0085370 transcript:FBtr0343830)

HSP 1 Score: 50.0618 bits (118), Expect = 7.138e-9
Identity = 23/58 (39.66%), Postives = 38/58 (65.52%), Query Frame = 3 
Query:   12 ALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKS-IGQLPIRLMDRDYKLELP 182
            A+SMT CDL ++ K W+++  +  ++  EF+ QGD EK  +   PI +M+R+ + ELP
Sbjct: 1004 AMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELP 1061
[Close]
BLAST of Phosphodiesterase vs. Ensembl Fly
Match: Pde11 (gene:FBgn0085370 transcript:FBtr0303162)

HSP 1 Score: 49.6766 bits (117), Expect = 9.742e-9
Identity = 23/58 (39.66%), Postives = 38/58 (65.52%), Query Frame = 3 
Query:   12 ALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKS-IGQLPIRLMDRDYKLELP 182
            A+SMT CDL ++ K W+++  +  ++  EF+ QGD EK  +   PI +M+R+ + ELP
Sbjct: 1004 AMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELP 1061
[Close]
BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde10a (phosphodiesterase 10A [Source:ZFIN;Acc:ZDB-GENE-040426-1115])

HSP 1 Score: 62.7734 bits (151), Expect = 3.067e-13
Identity = 29/59 (49.15%), Postives = 36/59 (61.02%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDLCS+ K W +       I  EFW +GDE K IG  PI +MDRD K E+P+
Sbjct:  665 IGLMMTACDLCSVTKLWPVTRLTANDIYAEFWAEGDEMKKIGMQPISMMDRDKKDEVPQ 723
[Close]
BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde10a (phosphodiesterase 10A [Source:ZFIN;Acc:ZDB-GENE-040426-1115])

HSP 1 Score: 60.8474 bits (146), Expect = 1.731e-12
Identity = 29/59 (49.15%), Postives = 36/59 (61.02%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDLCS+ K W +       I  EFW +GDE K IG  PI +MDRD K E+P+
Sbjct:  665 IGLMMTACDLCSVTKLWPVTRLTANDIYAEFWAEGDEMKKIGMQPISMMDRDKKDEVPQ 723
[Close]
BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde10a (phosphodiesterase 10A [Source:ZFIN;Acc:ZDB-GENE-040426-1115])

HSP 1 Score: 60.4622 bits (145), Expect = 1.905e-12
Identity = 29/59 (49.15%), Postives = 36/59 (61.02%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDLCS+ K W +       I  EFW +GDE K IG  PI +MDRD K E+P+
Sbjct:  666 IGLMMTACDLCSVTKLWPVTRLTANDIYAEFWAEGDEMKKIGMQPISMMDRDKKDEVPQ 724
[Close]
BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde6c (phosphodiesterase 6C, cGMP-specific, cone, alpha prime [Source:ZFIN;Acc:ZDB-GENE-040426-1664])

HSP 1 Score: 58.151 bits (139), Expect = 1.473e-11
Identity = 26/60 (43.33%), Postives = 41/60 (68.33%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + +++  EFW QGD E+++  Q PI +MDR+   ELP+
Sbjct:  710 MAMMMTGCDLSAITKPWEVQSKVALMVAAEFWEQGDLERTVLDQQPIPMMDRNKSDELPK 769
[Close]
BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Match: pde6b (phosphodiesterase 6B, cGMP-specific, rod, beta [Source:ZFIN;Acc:ZDB-GENE-090421-2])

HSP 1 Score: 56.6102 bits (135), Expect = 4.193e-11
Identity = 26/60 (43.33%), Postives = 40/60 (66.67%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + + +  EFW QGD E+++  Q PI +MDR+   ELP+
Sbjct:  711 MAMMMTACDLSAITKPWEVQSKVALSVAAEFWEQGDLERTVLEQQPIPMMDRNKAAELPK 770
[Close]
BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: PDE10A (phosphodiesterase 10A [Source:NCBI gene;Acc:100485841])

HSP 1 Score: 61.2326 bits (147), Expect = 1.409e-12
Identity = 28/59 (47.46%), Postives = 38/59 (64.41%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDLCS+ K W +   +   I  EFWT+GDE K +G  PI +MDRD + E+P+
Sbjct:  597 IGLMMTACDLCSVTKLWPVTRLIADDIYAEFWTEGDEMKRLGISPIPMMDRDKQDEIPQ 655
[Close]
BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: PDE10A (phosphodiesterase 10A [Source:NCBI gene;Acc:100485841])

HSP 1 Score: 61.2326 bits (147), Expect = 1.425e-12
Identity = 28/59 (47.46%), Postives = 38/59 (64.41%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDLCS+ K W +   +   I  EFWT+GDE K +G  PI +MDRD + E+P+
Sbjct:  633 IGLMMTACDLCSVTKLWPVTRLIADDIYAEFWTEGDEMKRLGISPIPMMDRDKQDEIPQ 691
[Close]
BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: PDE10A (phosphodiesterase 10A [Source:NCBI gene;Acc:100485841])

HSP 1 Score: 61.2326 bits (147), Expect = 1.508e-12
Identity = 28/59 (47.46%), Postives = 38/59 (64.41%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDLCS+ K W +   +   I  EFWT+GDE K +G  PI +MDRD + E+P+
Sbjct:  598 IGLMMTACDLCSVTKLWPVTRLIADDIYAEFWTEGDEMKRLGISPIPMMDRDKQDEIPQ 656
[Close]
BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: PDE10A (phosphodiesterase 10A [Source:NCBI gene;Acc:100485841])

HSP 1 Score: 61.2326 bits (147), Expect = 1.509e-12
Identity = 28/59 (47.46%), Postives = 38/59 (64.41%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDLCS+ K W +   +   I  EFWT+GDE K +G  PI +MDRD + E+P+
Sbjct:  627 IGLMMTACDLCSVTKLWPVTRLIADDIYAEFWTEGDEMKRLGISPIPMMDRDKQDEIPQ 685
[Close]
BLAST of Phosphodiesterase vs. Ensembl Xenopus
Match: PDE10A (phosphodiesterase 10A [Source:NCBI gene;Acc:100485841])

HSP 1 Score: 61.2326 bits (147), Expect = 1.511e-12
Identity = 28/59 (47.46%), Postives = 38/59 (64.41%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDLCS+ K W +   +   I  EFWT+GDE K +G  PI +MDRD + E+P+
Sbjct:  649 IGLMMTACDLCSVTKLWPVTRLIADDIYAEFWTEGDEMKRLGISPIPMMDRDKQDEIPQ 707
[Close]
BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde6c (phosphodiesterase 6C, cGMP specific, cone, alpha prime [Source:MGI Symbol;Acc:MGI:105956])

HSP 1 Score: 58.9214 bits (141), Expect = 7.414e-12
Identity = 27/60 (45.00%), Postives = 41/60 (68.33%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + +++  EFW QGD E+++  Q PI +MDR  K ELP+
Sbjct:  715 MAMMMTACDLSAITKPWEVQSQVALLVANEFWEQGDLERTVLQQQPIPMMDRSKKDELPK 774
[Close]
BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde6b (phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide [Source:MGI Symbol;Acc:MGI:97525])

HSP 1 Score: 58.151 bits (139), Expect = 1.441e-11
Identity = 26/60 (43.33%), Postives = 41/60 (68.33%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + +++  EFW QGD E+++  Q PI +MDR+   ELP+
Sbjct:  710 MAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPK 769
[Close]
BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde10a (phosphodiesterase 10A [Source:MGI Symbol;Acc:MGI:1345143])

HSP 1 Score: 57.3806 bits (137), Expect = 3.001e-11
Identity = 27/59 (45.76%), Postives = 36/59 (61.02%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDLCS+ K W +       I  EFW +GDE K +G  PI +MDRD + E+P+
Sbjct:  720 IGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQ 778
[Close]
BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde10a (phosphodiesterase 10A [Source:MGI Symbol;Acc:MGI:1345143])

HSP 1 Score: 57.3806 bits (137), Expect = 3.143e-11
Identity = 27/59 (45.76%), Postives = 36/59 (61.02%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDLCS+ K W +       I  EFW +GDE K +G  PI +MDRD + E+P+
Sbjct:  597 IGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQ 655
[Close]
BLAST of Phosphodiesterase vs. Ensembl Mouse
Match: Pde10a (phosphodiesterase 10A [Source:MGI Symbol;Acc:MGI:1345143])

HSP 1 Score: 57.3806 bits (137), Expect = 3.147e-11
Identity = 27/59 (45.76%), Postives = 36/59 (61.02%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDLCS+ K W +       I  EFW +GDE K +G  PI +MDRD + E+P+
Sbjct:  649 IGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQ 707
[Close]
BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|P16586|PDE6C_BOVIN (Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' OS=Bos taurus OX=9913 GN=PDE6C PE=1 SV=1)

HSP 1 Score: 60.8474 bits (146), Expect = 1.245e-11
Identity = 27/60 (45.00%), Postives = 42/60 (70.00%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + +++  EFW QGD E+++  Q PI +MDR+ K ELP+
Sbjct:  710 MAMMMTACDLSAITKPWEVQSQVALLVANEFWEQGDLERTVLQQQPIPMMDRNKKDELPK 769
[Close]
BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q91ZQ1|PDE6C_MOUSE (Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' OS=Mus musculus OX=10090 GN=Pde6c PE=2 SV=1)

HSP 1 Score: 58.9214 bits (141), Expect = 5.186e-11
Identity = 27/60 (45.00%), Postives = 41/60 (68.33%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + +++  EFW QGD E+++  Q PI +MDR  K ELP+
Sbjct:  715 MAMMMTACDLSAITKPWEVQSQVALLVANEFWEQGDLERTVLQQQPIPMMDRSKKDELPK 774
[Close]
BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|P51160|PDE6C_HUMAN (Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' OS=Homo sapiens OX=9606 GN=PDE6C PE=1 SV=2)

HSP 1 Score: 58.5362 bits (140), Expect = 7.446e-11
Identity = 26/60 (43.33%), Postives = 42/60 (70.00%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + +++  EFW QGD E+++  Q PI +MDR+ + ELP+
Sbjct:  715 MAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPK 774
[Close]
BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|P35913|PDE6B_HUMAN (Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta OS=Homo sapiens OX=9606 GN=PDE6B PE=1 SV=2)

HSP 1 Score: 58.151 bits (139), Expect = 9.600e-11
Identity = 26/60 (43.33%), Postives = 41/60 (68.33%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + +++  EFW QGD E+++  Q PI +MDR+   ELP+
Sbjct:  710 MAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPK 769
[Close]
BLAST of Phosphodiesterase vs. UniProt/SwissProt
Match: sp|P33726|PDE6B_CANLF (Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta OS=Canis lupus familiaris OX=9615 GN=PDE6B PE=1 SV=1)

HSP 1 Score: 58.151 bits (139), Expect = 9.695e-11
Identity = 26/60 (43.33%), Postives = 41/60 (68.33%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + +++  EFW QGD E+++  Q PI +MDR+   ELP+
Sbjct:  710 MAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPK 769
[Close]
BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A2C9JI04 (Phosphodiesterase OS=Biomphalaria glabrata OX=6526 GN=106066461 PE=3 SV=1)

HSP 1 Score: 87.0409 bits (214), Expect = 2.320e-18
Identity = 38/57 (66.67%), Postives = 47/57 (82.46%), Query Frame = 3 
Query:   12 ALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELP 182
            A++MT CDLC+M+K WD+QL+LV IIM EFW QGDEEK  G +PI++MDRD K ELP
Sbjct:  582 AVAMTACDLCAMYKPWDVQLSLVYIIMEEFWQQGDEEKRRGLIPIQMMDRDKKEELP 638
[Close]
BLAST of Phosphodiesterase vs. TrEMBL
Match: V4BHX7 (PDEase domain-containing protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_228057 PE=3 SV=1)

HSP 1 Score: 86.2705 bits (212), Expect = 2.600e-18
Identity = 39/59 (66.10%), Postives = 46/59 (77.97%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            MA+SMT CDLC+M K WD+QL LV +IM EFW QGDEEKS G  PI +MDRD + ELP+
Sbjct:  330 MAISMTGCDLCAMHKPWDIQLNLVSVIMEEFWQQGDEEKSQGLTPIPMMDRDKQSELPQ 388
[Close]
BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A2C9JI08 (Phosphodiesterase OS=Biomphalaria glabrata OX=6526 GN=106066461 PE=3 SV=1)

HSP 1 Score: 86.6557 bits (213), Expect = 2.873e-18
Identity = 38/57 (66.67%), Postives = 47/57 (82.46%), Query Frame = 3 
Query:   12 ALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELP 182
            A++MT CDLC+M+K WD+QL+LV IIM EFW QGDEEK  G +PI++MDRD K ELP
Sbjct:  438 AVAMTACDLCAMYKPWDVQLSLVYIIMEEFWQQGDEEKRRGLIPIQMMDRDKKEELP 494
[Close]
BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A0B6ZBA6 (PDEase domain-containing protein (Fragment) OS=Arion vulgaris OX=1028688 GN=ORF56024 PE=4 SV=1)

HSP 1 Score: 81.2629 bits (199), Expect = 8.507e-18
Identity = 36/58 (62.07%), Postives = 46/58 (79.31%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELP 182
            +A++MT CDLC+M+K WD+Q TLV IIM EFW QGDEEK  G  P+++MDRD K +LP
Sbjct:   63 LAVTMTACDLCAMYKPWDVQQTLVYIIMEEFWEQGDEEKKRGLTPMQMMDRDKKDDLP 120
[Close]
BLAST of Phosphodiesterase vs. TrEMBL
Match: A0A1S3J205 (Phosphodiesterase OS=Lingula unguis OX=7574 GN=LOC106169386 PE=3 SV=1)

HSP 1 Score: 84.3445 bits (207), Expect = 1.746e-17
Identity = 35/59 (59.32%), Postives = 44/59 (74.58%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            MA  MT  DLCSM+K WD+Q+ LV +IM EFW QGDEEK  G +P+R+MDR +  ELP+
Sbjct:  765 MAHCMTAADLCSMYKPWDLQVELVHVIMEEFWQQGDEEKKNGLMPLRMMDRSFAHELPD 823
[Close]
BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: pde10a (phosphodiesterase 10A [Source:ZFIN;Acc:ZDB-GENE-040426-1115])

HSP 1 Score: 60.8474 bits (146), Expect = 1.330e-12
Identity = 29/59 (49.15%), Postives = 37/59 (62.71%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDLCS+ K W +       I  EFW++GDE K IG  PI +MDRD K E+P+
Sbjct:  688 IGLMMTACDLCSVTKLWPVTRLTANDIYAEFWSEGDEMKKIGMQPIPMMDRDKKDEVPQ 746
[Close]
BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: pde6c (phosphodiesterase 6C [Source:NCBI gene;Acc:103038381])

HSP 1 Score: 58.9214 bits (141), Expect = 5.653e-12
Identity = 27/60 (45.00%), Postives = 41/60 (68.33%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + +++  EFW QGD E+ +  Q PI +MDR+ K ELP+
Sbjct:  710 MAMMMTGCDLSAITKPWEVQSKVALMVAAEFWEQGDLEREVLQQEPIPMMDRNKKDELPK 769
[Close]
BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: pde6a (phosphodiesterase 6A [Source:NCBI gene;Acc:103038023])

HSP 1 Score: 55.8398 bits (133), Expect = 8.163e-11
Identity = 25/60 (41.67%), Postives = 40/60 (66.67%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + + +  EFW QGD E+++  Q PI +MDR+   +LP+
Sbjct:  713 MAMMMTACDLSAIAKPWEIQSKVALSVAAEFWEQGDLERTVLEQQPIPMMDRNKAADLPK 772
[Close]
BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: pde6a (phosphodiesterase 6A [Source:NCBI gene;Acc:103038023])

HSP 1 Score: 55.8398 bits (133), Expect = 8.163e-11
Identity = 25/60 (41.67%), Postives = 40/60 (66.67%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + + +  EFW QGD E+++  Q PI +MDR+   +LP+
Sbjct:  713 MAMMMTACDLSAIAKPWEIQSKVALSVAAEFWEQGDLERTVLEQQPIPMMDRNKAADLPK 772
[Close]
BLAST of Phosphodiesterase vs. Ensembl Cavefish
Match: pde6a (phosphodiesterase 6A [Source:NCBI gene;Acc:103038023])

HSP 1 Score: 55.4546 bits (132), Expect = 8.915e-11
Identity = 25/60 (41.67%), Postives = 40/60 (66.67%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + + +  EFW QGD E+++  Q PI +MDR+   +LP+
Sbjct:  725 MAMMMTACDLSAIAKPWEIQSKVALSVAAEFWEQGDLERTVLEQQPIPMMDRNKAADLPK 784
[Close]
BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Match: PDE2A (phosphodiesterase 2A [Source:HGNC Symbol;Acc:HGNC:8777])

HSP 1 Score: 49.6766 bits (117), Expect = 2.521e-9
Identity = 24/59 (40.68%), Postives = 35/59 (59.32%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDL    K W     +  +I +EF++QGD EK++G  P  +MDR+ K  +PE
Sbjct:  484 LCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPSEMMDRE-KAYIPE 541
[Close]
BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Match: pde5ab (phosphodiesterase 5A, cGMP-specific, b [Source:ZFIN;Acc:ZDB-GENE-060824-4])

HSP 1 Score: 41.2022 bits (95), Expect = 2.194e-6
Identity = 18/58 (31.03%), Postives = 35/58 (60.34%), Query Frame = 3 
Query:   12 ALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKS-IGQLPIRLMDRDYKLELP 182
            A+ MT CD+ ++ K W +Q  +  ++  EF+ QGD E+  +   P  +M+R+ + ++P
Sbjct:  711 AMMMTACDVSAITKPWPVQQKIAELVASEFFDQGDRERQELHVEPTDMMNREKRDKIP 768
[Close]
BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO32088 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SW30])

HSP 1 Score: 60.077 bits (144), Expect = 9.289e-13
Identity = 27/57 (47.37%), Postives = 37/57 (64.91%), Query Frame = 3 
Query:   15 LSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            L MT CDLC+  K WD+Q+  V  +  EF+ QGDEE+ +G  P+ +MDR    +LPE
Sbjct:  512 LLMTACDLCTSAKPWDIQVVAVNKVFEEFYIQGDEERKMGLDPLPMMDRSKHDDLPE 568
[Close]
BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO44626 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVE3])

HSP 1 Score: 56.6102 bits (135), Expect = 1.631e-11
Identity = 25/57 (43.86%), Postives = 37/57 (64.91%), Query Frame = 3 
Query:   12 ALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELP 182
            A+ MT CDL +  K W +Q  +V +I +EF+ +GD EK+ G+ PI + DR+   ELP
Sbjct:  527 AICMTACDLSACTKPWRIQYKIVEVIYQEFYAEGDLEKAQGKQPIPMKDRNTAHELP 583
[Close]
BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO42681 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0H3])

HSP 1 Score: 48.521 bits (114), Expect = 8.768e-9
Identity = 23/58 (39.66%), Postives = 37/58 (63.79%), Query Frame = 3 
Query:   12 ALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGD-EEKSIGQLPIRLMDRDYKLELP 182
            A+ MT CD+ ++ K W++Q  +  ++  EF+ QGD E++ +   PI +MDR  K ELP
Sbjct:  162 AMMMTACDVAAITKPWEIQRVVAEMVASEFFDQGDLEKEKLNAEPIPMMDRRKKNELP 219
[Close]
BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO43657 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RY89])

HSP 1 Score: 48.521 bits (114), Expect = 1.156e-8
Identity = 24/59 (40.68%), Postives = 36/59 (61.02%), Query Frame = 3 
Query:   12 ALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQL-PIRLMDRDYKLELPE 185
            A+ MT CDL    K W++Q  +V ++ REF+ QGD E+    + P+ +MDR    ELP+
Sbjct:  618 AMMMTACDLNGTTKPWEIQKEVVNLVTREFFEQGDMERERYNMEPMAIMDRQKIDELPK 676
[Close]
BLAST of Phosphodiesterase vs. Ensembl Nematostella
Match: EDO39522 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9Q1])

HSP 1 Score: 45.8246 bits (107), Expect = 1.053e-7
Identity = 23/59 (38.98%), Postives = 35/59 (59.32%), Query Frame = 3 
Query:   12 ALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGD-EEKSIGQLPIRLMDRDYKLELPE 185
            A+ MT CDL ++ K W +Q     ++  EF+ QGD E++ +   P+  MDR  K ELP+
Sbjct:  716 AMMMTACDLSAITKPWLVQKRTAHLVAEEFFQQGDLEQEELHSTPLPTMDRRKKDELPQ 774
[Close]
BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: pde10a (phosphodiesterase 10A [Source:NCBI gene;Acc:101162470])

HSP 1 Score: 64.6994 bits (156), Expect = 6.328e-14
Identity = 30/59 (50.85%), Postives = 36/59 (61.02%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDLCS+ K W +       I  EFW +GDE K IG  PI +MDRD K E+PE
Sbjct:  669 IGLMMTACDLCSVTKQWQITRLTANDIYAEFWAEGDEMKKIGIQPIPMMDRDKKDEVPE 727
[Close]
BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: pde10a (phosphodiesterase 10A [Source:NCBI gene;Acc:101162470])

HSP 1 Score: 64.3142 bits (155), Expect = 7.119e-14
Identity = 30/59 (50.85%), Postives = 36/59 (61.02%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDLCS+ K W +       I  EFW +GDE K IG  PI +MDRD K E+PE
Sbjct:  697 IGLMMTACDLCSVTKQWQITRLTANDIYAEFWAEGDEMKKIGIQPIPMMDRDKKDEVPE 755
[Close]
BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: pde10a (phosphodiesterase 10A [Source:NCBI gene;Acc:101162470])

HSP 1 Score: 64.3142 bits (155), Expect = 7.768e-14
Identity = 30/59 (50.85%), Postives = 36/59 (61.02%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            + L MT CDLCS+ K W +       I  EFW +GDE K IG  PI +MDRD K E+PE
Sbjct:  666 IGLMMTACDLCSVTKQWQITRLTANDIYAEFWAEGDEMKKIGIQPIPMMDRDKKDEVPE 724
[Close]
BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: pde6c (phosphodiesterase 6C [Source:NCBI gene;Acc:101163363])

HSP 1 Score: 58.151 bits (139), Expect = 1.252e-11
Identity = 26/60 (43.33%), Postives = 41/60 (68.33%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + +++  EFW QGD E+S+  Q PI +MDR+   +LP+
Sbjct:  713 MAMMMTGCDLSAITKPWEVQSKVALMVAAEFWEQGDLERSVLDQQPIPMMDRNCAEQLPK 772
[Close]
BLAST of Phosphodiesterase vs. Ensembl Medaka
Match: pde6b (rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta-like [Source:NCBI gene;Acc:101169549])

HSP 1 Score: 56.9954 bits (136), Expect = 3.362e-11
Identity = 26/60 (43.33%), Postives = 40/60 (66.67%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSI-GQLPIRLMDRDYKLELPE 185
            MA+ MT CDL ++ K W++Q  + + +  EFW QGD E+++  Q PI +MDR+   ELP+
Sbjct:  712 MAMMMTACDLSAITKPWEVQSKVALSVAAEFWEQGDLERTVLEQQPIPMMDRNKAAELPK 771
[Close]
BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000044149.1 (SMESG000044149.1)

HSP 1 Score: 136.732 bits (343), Expect = 1.838e-39
Identity = 61/61 (100.00%), Postives = 61/61 (100.00%), Query Frame = 3 
Query:    3 LHMALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            LHMALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE
Sbjct:  795 LHMALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 855
[Close]
BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000044149.1 (SMESG000044149.1)

HSP 1 Score: 136.732 bits (343), Expect = 1.888e-39
Identity = 61/61 (100.00%), Postives = 61/61 (100.00%), Query Frame = 3 
Query:    3 LHMALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            LHMALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE
Sbjct:  777 LHMALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 837
[Close]
BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000044149.1 (SMESG000044149.1)

HSP 1 Score: 135.961 bits (341), Expect = 3.518e-39
Identity = 61/61 (100.00%), Postives = 61/61 (100.00%), Query Frame = 3 
Query:    3 LHMALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 185
            LHMALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE
Sbjct:  777 LHMALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELPE 837
[Close]
BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000045774.1 (SMESG000045774.1)

HSP 1 Score: 75.485 bits (184), Expect = 6.751e-18
Identity = 34/58 (58.62%), Postives = 40/58 (68.97%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELP 182
            M L MT  DL +M+K WDMQL  V +IM+EFW QGD EK  G +P R+MDR Y  ELP
Sbjct:  360 MELFMTAGDLSAMYKPWDMQLNFVKVIMQEFWDQGDVEKQEGSVPARMMDRAYNYELP 417
[Close]
BLAST of Phosphodiesterase vs. Planmine SMEST
Match: SMESG000045774.1 (SMESG000045774.1)

HSP 1 Score: 74.7146 bits (182), Expect = 1.258e-17
Identity = 34/58 (58.62%), Postives = 40/58 (68.97%), Query Frame = 3 
Query:    9 MALSMTFCDLCSMFKSWDMQLTLVMIIMREFWTQGDEEKSIGQLPIRLMDRDYKLELP 182
            M L MT  DL +M+K WDMQL  V +IM+EFW QGD EK  G +P R+MDR Y  ELP
Sbjct:  397 MELFMTAGDLSAMYKPWDMQLNFVKVIMQEFWDQGDVEKQEGSVPARMMDRAYNYELP 454
The following BLAST results are available for this feature:
BLAST of Phosphodiesterase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PDE6B2.579e-1243.33phosphodiesterase 6B [Source:HGNC Symbol;Acc:HGNC:... [more]
PDE10A2.625e-1247.46phosphodiesterase 10A [Source:HGNC Symbol;Acc:HGNC... [more]
PDE6C1.550e-1143.33phosphodiesterase 6C [Source:HGNC Symbol;Acc:HGNC:... [more]
PDE10A1.939e-1147.46phosphodiesterase 10A [Source:HGNC Symbol;Acc:HGNC... [more]
PDE6B1.964e-1143.33phosphodiesterase 6B [Source:HGNC Symbol;Acc:HGNC:... [more]
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BLAST of Phosphodiesterase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pde-51.056e-1042.62Probable 3',5'-cyclic phosphodiesterase pde-5 [So... [more]
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BLAST of Phosphodiesterase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pde117.136e-939.66gene:FBgn0085370 transcript:FBtr0343831[more]
Pde117.136e-939.66gene:FBgn0085370 transcript:FBtr0112545[more]
Pde117.138e-939.66gene:FBgn0085370 transcript:FBtr0112544[more]
Pde117.138e-939.66gene:FBgn0085370 transcript:FBtr0343830[more]
Pde119.742e-939.66gene:FBgn0085370 transcript:FBtr0303162[more]
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BLAST of Phosphodiesterase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pde10a3.067e-1349.15phosphodiesterase 10A [Source:ZFIN;Acc:ZDB-GENE-04... [more]
pde10a1.731e-1249.15phosphodiesterase 10A [Source:ZFIN;Acc:ZDB-GENE-04... [more]
pde10a1.905e-1249.15phosphodiesterase 10A [Source:ZFIN;Acc:ZDB-GENE-04... [more]
pde6c1.473e-1143.33phosphodiesterase 6C, cGMP-specific, cone, alpha p... [more]
pde6b4.193e-1143.33phosphodiesterase 6B, cGMP-specific, rod, beta [So... [more]
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BLAST of Phosphodiesterase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PDE10A1.409e-1247.46phosphodiesterase 10A [Source:NCBI gene;Acc:100485... [more]
PDE10A1.425e-1247.46phosphodiesterase 10A [Source:NCBI gene;Acc:100485... [more]
PDE10A1.508e-1247.46phosphodiesterase 10A [Source:NCBI gene;Acc:100485... [more]
PDE10A1.509e-1247.46phosphodiesterase 10A [Source:NCBI gene;Acc:100485... [more]
PDE10A1.511e-1247.46phosphodiesterase 10A [Source:NCBI gene;Acc:100485... [more]
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BLAST of Phosphodiesterase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pde6c7.414e-1245.00phosphodiesterase 6C, cGMP specific, cone, alpha p... [more]
Pde6b1.441e-1143.33phosphodiesterase 6B, cGMP, rod receptor, beta pol... [more]
Pde10a3.001e-1145.76phosphodiesterase 10A [Source:MGI Symbol;Acc:MGI:1... [more]
Pde10a3.143e-1145.76phosphodiesterase 10A [Source:MGI Symbol;Acc:MGI:1... [more]
Pde10a3.147e-1145.76phosphodiesterase 10A [Source:MGI Symbol;Acc:MGI:1... [more]
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BLAST of Phosphodiesterase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P16586|PDE6C_BOVIN1.245e-1145.00Cone cGMP-specific 3',5'-cyclic phosphodiesterase ... [more]
sp|Q91ZQ1|PDE6C_MOUSE5.186e-1145.00Cone cGMP-specific 3',5'-cyclic phosphodiesterase ... [more]
sp|P51160|PDE6C_HUMAN7.446e-1143.33Cone cGMP-specific 3',5'-cyclic phosphodiesterase ... [more]
sp|P35913|PDE6B_HUMAN9.600e-1143.33Rod cGMP-specific 3',5'-cyclic phosphodiesterase s... [more]
sp|P33726|PDE6B_CANLF9.695e-1143.33Rod cGMP-specific 3',5'-cyclic phosphodiesterase s... [more]
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BLAST of Phosphodiesterase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2C9JI042.320e-1866.67Phosphodiesterase OS=Biomphalaria glabrata OX=6526... [more]
V4BHX72.600e-1866.10PDEase domain-containing protein OS=Lottia gigante... [more]
A0A2C9JI082.873e-1866.67Phosphodiesterase OS=Biomphalaria glabrata OX=6526... [more]
A0A0B6ZBA68.507e-1862.07PDEase domain-containing protein (Fragment) OS=Ari... [more]
A0A1S3J2051.746e-1759.32Phosphodiesterase OS=Lingula unguis OX=7574 GN=LOC... [more]
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BLAST of Phosphodiesterase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pde10a1.330e-1249.15phosphodiesterase 10A [Source:ZFIN;Acc:ZDB-GENE-04... [more]
pde6c5.653e-1245.00phosphodiesterase 6C [Source:NCBI gene;Acc:1030383... [more]
pde6a8.163e-1141.67phosphodiesterase 6A [Source:NCBI gene;Acc:1030380... [more]
pde6a8.163e-1141.67phosphodiesterase 6A [Source:NCBI gene;Acc:1030380... [more]
pde6a8.915e-1141.67phosphodiesterase 6A [Source:NCBI gene;Acc:1030380... [more]
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BLAST of Phosphodiesterase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
PDE2A2.521e-940.68phosphodiesterase 2A [Source:HGNC Symbol;Acc:HGNC:... [more]
pde5ab2.194e-631.03phosphodiesterase 5A, cGMP-specific, b [Source:ZFI... [more]
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BLAST of Phosphodiesterase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Phosphodiesterase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO320889.289e-1347.37Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO446261.631e-1143.86Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO426818.768e-939.66Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO436571.156e-840.68Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO395221.053e-738.98Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Phosphodiesterase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pde10a6.328e-1450.85phosphodiesterase 10A [Source:NCBI gene;Acc:101162... [more]
pde10a7.119e-1450.85phosphodiesterase 10A [Source:NCBI gene;Acc:101162... [more]
pde10a7.768e-1450.85phosphodiesterase 10A [Source:NCBI gene;Acc:101162... [more]
pde6c1.252e-1143.33phosphodiesterase 6C [Source:NCBI gene;Acc:1011633... [more]
pde6b3.362e-1143.33rod cGMP-specific 3',5'-cyclic phosphodiesterase s... [more]
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BLAST of Phosphodiesterase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000044149.11.838e-39100.00SMESG000044149.1[more]
SMESG000044149.11.888e-39100.00SMESG000044149.1[more]
SMESG000044149.13.518e-39100.00SMESG000044149.1[more]
SMESG000045774.16.751e-1858.62SMESG000045774.1[more]
SMESG000045774.11.258e-1758.62SMESG000045774.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30025517 ID=SMED30025517|Name=Phosphodiesterase|organism=Schmidtea mediterranea sexual|type=transcript|length=185bp
TGTTGCACATGGCTTTATCAATGACTTTCTGTGACTTGTGCTCCATGTTC
AAGTCCTGGGACATGCAGTTGACATTGGTGATGATTATAATGCGCGAGTT
TTGGACTCAGGGTGATGAGGAGAAGTCCATTGGGCAACTGCCAATTAGAT
TAATGGACAGAGATTACAAATTAGAACTGCCTGAA
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000420parapharyngeal region
Vocabulary: INTERPRO
TermDefinition
IPR036971PDEase_catalytic_dom_sf
IPR002073PDEase_catalytic_dom
Vocabulary: molecular function
TermDefinition
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081phosphoric diester hydrolase activity
GO:0016787hydrolase activity
GO:0046872metal ion binding
Vocabulary: biological process
TermDefinition
GO:0007165signal transduction
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR0020733'5'-cyclic nucleotide phosphodiesterase, catalytic domainPFAMPF00233PDEase_Icoord: 3..55
e-value: 1.0E-9
score: 38.5
IPR0020733'5'-cyclic nucleotide phosphodiesterase, catalytic domainPROSITEPS51845PDEASE_I_2coord: 1..61
score: 19.678
IPR0369713'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyGENE3DG3DSA:1.10.1300.10coord: 1..61
e-value: 7.3E-13
score: 50.3
NoneNo IPR availablePANTHERPTHR11347:SF111CAMP AND CAMP-INHIBITED CGMP 3',5'-CYCLIC PHOSPHODIESTERASE 10Acoord: 3..60
NoneNo IPR availablePANTHERPTHR11347CYCLIC NUCLEOTIDE PHOSPHODIESTERASEcoord: 3..60
NoneNo IPR availableSUPERFAMILYSSF109604HD-domain/PDEase-likecoord: 2..60