rap guanine nucleotide exchange factor 2 isoform X2

Overview


Name	rap guanine nucleotide exchange factor 2 isoform X2
Smed ID	SMED30025424
Length (bp)	5380

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of rap guanine nucleotide exchange factor 2 isoform X2 (SMED30025424) t-SNE clustered cells

Violin plots show distribution of expression levels for rap guanine nucleotide exchange factor 2 isoform X2 (SMED30025424) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of rap guanine nucleotide exchange factor 2 isoform X2 (SMED30025424) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Homology

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BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Human
Match: RAPGEF2 (Rap guanine nucleotide exchange factor 2 [Source:HGNC Symbol;Acc:HGNC:16854])

HSP 1 Score: 180.644 bits (457), Expect = 9.490e-45
Identity = 126/453 (27.81%), Postives = 233/453 (51.43%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   + + K++ +S Y++ISK+T A EV+++++ E  ++ A+  ++ LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  +  F+ I  +E ID +  KLR ++                             S  N + F ++  +  ++V + +  ETN   KR KI+K  I++A  C+E  N    F++++GL+   ++RLR TW+++PNK  K+++ +Q L D S NM   R++   ++ +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+                F    LS+     +   ++ +  H  R RRS+ +N KK+YE+     +VK ++  +E +E D+  L  +S +CEP
Sbjct:  649 PDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVT-ATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF-KLRSKT-----------------------------SCANLKRFEEVINQETFWVASEILRETNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALM---------------FRTRSLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLE-LEMDEESLQTLSLQCEP 1037

HSP 2 Score: 135.191 bits (339), Expect = 6.434e-31
Identity = 103/410 (25.12%), Postives = 183/410 (44.63%), Query Frame = 2

Query:  773 NEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREF-MSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            + +  +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV                   E L   +SFG      +E + K  + +  +DC  + I  +++ +I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD TFIEDF LTY  +L+S + V K ++E     S  R K T +V+ W+ NHF + E    + +F++     L RE    H   +   C+  + +R                              +MT+    RE  + F L    +K   +F+  + + S      L  GD+++++N  + EN+   +A  IL  +    +TVK
Sbjct:  142 DPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYP------------DGKAEILCMGNSFGVSPTMDKEYM-KGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRR------------------------------LMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVK 507

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Human
Match: RAPGEF2 (Rap guanine nucleotide exchange factor 2 [Source:HGNC Symbol;Acc:HGNC:16854])

HSP 1 Score: 177.563 bits (449), Expect = 6.779e-44
Identity = 126/459 (27.45%), Postives = 237/459 (51.63%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   + + K++ +S Y++ISK+T A EV+++++ E  ++ A+  ++ LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  +  F+ I  +E ID +  KLR ++                             S  N + F ++  +  ++V + +  ETN   KR KI+K  I++A  C+E  N    F++++GL+   ++RLR TW+++PNK  K+++ +Q L D S NM   R++   ++ +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +E +E D+  L  +S +CEP
Sbjct:  606 PDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVT-ATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF-KLRSKT-----------------------------SCANLKRFEEVINQETFWVASEILRETNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDV-------------AQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLE-LEMDEESLQTLSLQCEP 1002

HSP 2 Score: 134.806 bits (338), Expect = 8.013e-31
Identity = 103/410 (25.12%), Postives = 183/410 (44.63%), Query Frame = 2

Query:  773 NEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREF-MSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            + +  +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV                   E L   +SFG      +E + K  + +  +DC  + I  +++ +I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD TFIEDF LTY  +L+S + V K ++E     S  R K T +V+ W+ NHF + E    + +F++     L RE    H   +   C+  + +R                              +MT+    RE  + F L    +K   +F+  + + S      L  GD+++++N  + EN+   +A  IL  +    +TVK
Sbjct:   99 DPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYP------------DGKAEILCMGNSFGVSPTMDKEYM-KGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRR------------------------------LMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVK 464

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Human
Match: RAPGEF2 (Rap guanine nucleotide exchange factor 2 [Source:HGNC Symbol;Acc:HGNC:16854])

HSP 1 Score: 177.563 bits (449), Expect = 7.375e-44
Identity = 126/459 (27.45%), Postives = 237/459 (51.63%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   + + K++ +S Y++ISK+T A EV+++++ E  ++ A+  ++ LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  +  F+ I  +E ID +  KLR ++                             S  N + F ++  +  ++V + +  ETN   KR KI+K  I++A  C+E  N    F++++GL+   ++RLR TW+++PNK  K+++ +Q L D S NM   R++   ++ +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +E +E D+  L  +S +CEP
Sbjct:  761 PDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVT-ATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF-KLRSKT-----------------------------SCANLKRFEEVINQETFWVASEILRETNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDV-------------AQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLE-LEMDEESLQTLSLQCEP 1157

HSP 2 Score: 135.191 bits (339), Expect = 6.340e-31
Identity = 103/410 (25.12%), Postives = 183/410 (44.63%), Query Frame = 2

Query:  773 NEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREF-MSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            + +  +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV                   E L   +SFG      +E + K  + +  +DC  + I  +++ +I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD TFIEDF LTY  +L+S + V K ++E     S  R K T +V+ W+ NHF + E    + +F++     L RE    H   +   C+  + +R                              +MT+    RE  + F L    +K   +F+  + + S      L  GD+++++N  + EN+   +A  IL  +    +TVK
Sbjct:  254 DPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYP------------DGKAEILCMGNSFGVSPTMDKEYM-KGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRR------------------------------LMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVK 619

HSP 3 Score: 67.3958 bits (163), Expect = 2.676e-10
Identity = 37/128 (28.91%), Postives = 64/128 (50.00%), Query Frame = 2

Query:  113 SNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSTIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFY 496
            S + NS   A+ ++P  R+ +++EI+  YL  +  L     +   L    V+Y+  + N  +    D    WY +L GSV I  +MFLP +SF  +   +     ECIVLE + +++  Y + N  ++
Sbjct:    3 SYVDNSFRQAVMKNPPERTPQDLEIVYSYLHGMEALSNLREHQLRLMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSFRRGCECIVLEPSEMIVVDYMDENEEYF 130

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Human
Match: RAPGEF6 (Rap guanine nucleotide exchange factor 6 [Source:HGNC Symbol;Acc:HGNC:20655])

HSP 1 Score: 166.392 bits (420), Expect = 1.498e-40
Identity = 122/452 (26.99%), Postives = 222/452 (49.12%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   I + K + +S Y+IISK+T A EV+  ++ E  L+ AS++ + LCE+SV    +IKQ+ + +  S L   ++LN R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  ++ F+ I  +E ID +  KL  ++ N                              + + F  +  +  ++V + + +E N   KR KI+K  I++A  C+E  N    F++++GL+   ++RLR TW+++P+K  K  + +Q + D S NM   R++   +S +PP+IP+  +V KD+T ++E + +KV  DG           L+NF+KLR++                  SK I     +   N    + F +  LS+     +   +    +    RRS+ +N KK+YE+     +VK ++  ++ +E D+     MS + EP
Sbjct:  415 PDQVIRVFKVDQQSCYIIISKDTTAKEVVFHAVHEFGLTGASDT-YSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLF-KLNSKTGNT-----------------------------HLKRFEDIVNQETFWVASEILTEANQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKV--DG-----------LVNFEKLRMI------------------SKEIRQVVRMTSANMDPAMMFRQRSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLD-VETDEEKFQMMSLQWEP 802

HSP 2 Score: 90.1225 bits (222), Expect = 3.788e-17
Identity = 73/272 (26.84%), Postives = 125/272 (45.96%), Query Frame = 2

Query: 1184 LMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
             + I  +++ +I +       ++ E  + VM+ E R     G+ KG +++KAT  +LI +L E H  VD T+IEDF LTY  +L S + V   ++E   ++   R K T IV+ W+ NHF + E    + +F++      F +N E+         + H    N+   +  K    R V++   SR S                + F+L    +K   +F+  +   S      L  GD+++++N  + EN+T  +A  IL  +    LTVK
Sbjct:   34 FVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWF-KIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLE-----EFEKNLEDTK------MNGHLRLLNIACAAKAK---WRQVVLQKASRESP---------------LQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRNNTHLALTVK 275

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Human
Match: RAPGEF6 (Rap guanine nucleotide exchange factor 6 [Source:HGNC Symbol;Acc:HGNC:20655])

HSP 1 Score: 166.007 bits (419), Expect = 2.916e-40
Identity = 122/452 (26.99%), Postives = 222/452 (49.12%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   I + K + +S Y+IISK+T A EV+  ++ E  L+ AS++ + LCE+SV    +IKQ+ + +  S L   ++LN R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  ++ F+ I  +E ID +  KL  ++ N                              + + F  +  +  ++V + + +E N   KR KI+K  I++A  C+E  N    F++++GL+   ++RLR TW+++P+K  K  + +Q + D S NM   R++   +S +PP+IP+  +V KD+T ++E + +KV  DG           L+NF+KLR++                  SK I     +   N    + F +  LS+     +   +    +    RRS+ +N KK+YE+     +VK ++  ++ +E D+     MS + EP
Sbjct:  749 PDQVIRVFKVDQQSCYIIISKDTTAKEVVFHAVHEFGLTGASDT-YSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLF-KLNSKTGNT-----------------------------HLKRFEDIVNQETFWVASEILTEANQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKV--DG-----------LVNFEKLRMI------------------SKEIRQVVRMTSANMDPAMMFRQRSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLD-VETDEEKFQMMSLQWEP 1136

HSP 2 Score: 129.028 bits (323), Expect = 4.628e-29
Identity = 101/407 (24.82%), Postives = 186/407 (45.70%), Query Frame = 2

Query:  779 ISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            +  +D +++ L+K  AD++  + E ++  +  +P F+  T S+R   C +   +VVE    ++++  +++  W   L GT+E+                  +E L   +SFG      ++Q     + +  +DC  + I  +++ +I +       ++ E  + VM+ E R     G+ KG +++KAT  +LI +L E H  VD T+IEDF LTY  +L S + V   ++E   ++   R K T IV+ W+ NHF + E    + +F++      F +N E+         + H    N+   +  K    R V++   SR S                + F+L    +K   +F+  +   S      L  GD+++++N  + EN+T  +A  IL  +    LTVK
Sbjct:  246 LQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEISHP------------DGKVENLFMGNSFGI-TPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWF-KIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEE-----FEKNLEDTK------MNGHLRLLNIACAAKAK---WRQVVLQKASRESP---------------LQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRNNTHLALTVK 609

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Celegans
Match: pxf-1 (Rap guanine nucleotide exchange factor [Source:UniProtKB/Swiss-Prot;Acc:G5EDB9])

HSP 1 Score: 156.377 bits (394), Expect = 6.909e-38
Identity = 121/444 (27.25%), Postives = 209/444 (47.07%), Query Frame = 2

Query: 2627 YLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRS--LHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNL---LYD-CSINSSKAITSTENLLPEN--EGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPR 3934
            YL + KET A  V+  +L E N++   + E+ LCE +V    +IKQ+ +     NL   + LN+R+++K    S  L+ +    E+  E       L    +A Q+ ++ ++ F  I  +E +D                             NL   D K  S    +EF +L  + M++V   +C+E +   KR K++K+ I++AR C++L N    F++M+GLD+  + RL ++W+RV +K ++M  ++ QL+D S NM   R      + +PPV+P+  ++ KDLT  ++ + T              +E LINF+KLR++A   R    L    Y+  S+         + LL  N  E + +A +R            KG+S  QN            KK+YE  +   +VK ++  +  ++ ++  L +MSY  EP+
Sbjct:  674 YLPVYKETSAQNVVQLALQEFNMTAEGSPEWSLCECTVTIDGVIKQRRLPPQMENLAERIALNSRYYLKNNSRSEPLVPDELAPELLKEAQTQLLSLNAQVVAAQLTLQDFSVFSAIEPTEFLD-----------------------------NLFKLDSKYGS-PKLEEFEQLFNREMWWVATEICTERH-VQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLHSSWERVSSKYIRMLDEIHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDGNATY-------------SEKLINFEKLRLIAKSIRGVMKLSSAPYEIASMAERSGGVVMDALLHMNSFENSNVATMR------------KGMSGKQNQPR---------KKVYEQALMVRKVKSYLEGLHVVD-NEMELDSMSYDIEPQ 1051

HSP 2 Score: 99.3673 bits (246), Expect = 1.822e-20
Identity = 80/324 (24.69%), Postives = 150/324 (46.30%), Query Frame = 2

Query:  779 ISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNK------TVMIMERRCSADGSTKGQVLVKATVRKLIEYLF-ENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGN 1729
            +  +D +++ L+K  ++R++++  V+++ +Q++  F+    S++   C      VV +  TV++  +EK+  W   + G +EV   V+   +  +  L D         SFGA+   +  QI    + +  +DC  +L+  ++F  I S    T+   IE ++       V  +ERR    G+  GQVL+K    KLI +L  E    VD  +++DF LTY +++     + + ++      S  R K   +V+ W+ NHF + E   E+   ++     L R+        +   CS  +  R V I++  KD      +VG 
Sbjct:  190 MDLRDSVRECLEKEPSERNSEDLAVLLDFMQHMSAFAALPMSIKRQLCLKMVFAVVNDAGTVVLAHNEKLDSWSVIVNGCVEV---VKPSGERVEYKLGD---------SFGAEPTPAT-QIHIGEMRTMVDDCEFVLVEHRDFCSIMS----TIGDHIEKDRDGLTGEVVSEVERRTV--GTHCGQVLIKGKPDKLIHHLVDERDHNVDPHYVDDFLLTYRVFIRDPTTIFEKLMLWFAD-SIYRDKVARLVLLWVNNHFNDFETNDEMWNLLERFEGALERDGMHSQLSLLNIACSVKAKPRQV-ILTRRKDDKMMMRLVGG 492

[Close]

Query: 2627 YLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRS--LHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNL---LYD-CSINSSKAITSTENLLPEN--EGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPR 3934
            YL + KET A  V+  +L E N++   + E+ LCE +V    +IKQ+ +     NL   + LN+R+++K    S  L+ +    E+  E       L    +A Q+ ++ ++ F  I  +E +D                             NL   D K  S    +EF +L  + M++V   +C+E +   KR K++K+ I++AR C++L N    F++M+GLD+  + RL ++W+RV +K ++M  ++ QL+D S NM   R      + +PPV+P+  ++ KDLT  ++ + T              +E LINF+KLR++A   R    L    Y+  S+         + LL  N  E + +A +R            KG+S  QN            KK+YE  +   +VK ++  +  ++ ++  L +MSY  EP+
Sbjct:  674 YLPVYKETSAQNVVQLALQEFNMTAEGSPEWSLCECTVTIDGVIKQRRLPPQMENLAERIALNSRYYLKNNSRSEPLVPDELAPELLKEAQTQLLSLNAQVVAAQLTLQDFSVFSAIEPTEFLD-----------------------------NLFKLDSKYGS-PKLEEFEQLFNREMWWVATEICTERH-VQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLHSSWERVSSKYIRMLDEIHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDGNATY-------------SEKLINFEKLRLIAKSIRGVMKLSSAPYEIASMAERSGGVVMDALLHMNSFENSNVATMR------------KGMSGKQNQPR---------KKVYEQALMVRKVKSYLEGLHVVD-NEMELDSMSYDIEPQ 1051

HSP 2 Score: 99.3673 bits (246), Expect = 1.822e-20
Identity = 80/324 (24.69%), Postives = 150/324 (46.30%), Query Frame = 2

Query:  779 ISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNK------TVMIMERRCSADGSTKGQVLVKATVRKLIEYLF-ENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGN 1729
            +  +D +++ L+K  ++R++++  V+++ +Q++  F+    S++   C      VV +  TV++  +EK+  W   + G +EV   V+   +  +  L D         SFGA+   +  QI    + +  +DC  +L+  ++F  I S    T+   IE ++       V  +ERR    G+  GQVL+K    KLI +L  E    VD  +++DF LTY +++     + + ++      S  R K   +V+ W+ NHF + E   E+   ++     L R+        +   CS  +  R V I++  KD      +VG 
Sbjct:  190 MDLRDSVRECLEKEPSERNSEDLAVLLDFMQHMSAFAALPMSIKRQLCLKMVFAVVNDAGTVVLAHNEKLDSWSVIVNGCVEV---VKPSGERVEYKLGD---------SFGAEPTPAT-QIHIGEMRTMVDDCEFVLVEHRDFCSIMS----TIGDHIEKDRDGLTGEVVSEVERRTV--GTHCGQVLIKGKPDKLIHHLVDERDHNVDPHYVDDFLLTYRVFIRDPTTIFEKLMLWFAD-SIYRDKVARLVLLWVNNHFNDFETNDEMWNLLERFEGALERDGMHSQLSLLNIACSVKAKPRQV-ILTRRKDDKMMMRLVGG 492

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Celegans
Match: pxf-1 (Rap guanine nucleotide exchange factor [Source:UniProtKB/Swiss-Prot;Acc:G5EDB9])

HSP 1 Score: 156.377 bits (394), Expect = 8.032e-38
Identity = 126/467 (26.98%), Postives = 216/467 (46.25%), Query Frame = 2

Query: 2558 VIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRS--LHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNL---LYD-CSINSSKAITSTENLLPEN--EGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPR 3934
            V+K+Y  D T             YL + KET A  V+  +L E N++   + E+ LCE +V    +IKQ+ +     NL   + LN+R+++K    S  L+ +    E+  E       L    +A Q+ ++ ++ F  I  +E +D                             NL   D K  S    +EF +L  + M++V   +C+E +   KR K++K+ I++AR C++L N    F++M+GLD+  + RL ++W+RV +K ++M  ++ QL+D S NM   R      + +PPV+P+  ++ KDLT  ++ + T              +E LINF+KLR++A   R    L    Y+  S+         + LL  N  E + +A +R            KG+S  QN            KK+YE  +   +VK ++  +  ++ ++  L +MSY  EP+
Sbjct:  620 VLKIYRNDQTFK-----------YLPVYKETSAQNVVQLALQEFNMTAEGSPEWSLCECTVTIDGVIKQRRLPPQMENLAERIALNSRYYLKNNSRSEPLVPDELAPELLKEAQTQLLSLNAQVVAAQLTLQDFSVFSAIEPTEFLD-----------------------------NLFKLDSKYGS-PKLEEFEQLFNREMWWVATEICTERH-VQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLHSSWERVSSKYIRMLDEIHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDGNATY-------------SEKLINFEKLRLIAKSIRGVMKLSSAPYEIASMAERSGGVVMDALLHMNSFENSNVATMR------------KGMSGKQNQPR---------KKVYEQALMVRKVKSYLEGLHVVD-NEMELDSMSYDIEPQ 1009

HSP 2 Score: 99.3673 bits (246), Expect = 1.952e-20
Identity = 80/324 (24.69%), Postives = 150/324 (46.30%), Query Frame = 2

Query:  779 ISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNK------TVMIMERRCSADGSTKGQVLVKATVRKLIEYLF-ENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGN 1729
            +  +D +++ L+K  ++R++++  V+++ +Q++  F+    S++   C      VV +  TV++  +EK+  W   + G +EV   V+   +  +  L D         SFGA+   +  QI    + +  +DC  +L+  ++F  I S    T+   IE ++       V  +ERR    G+  GQVL+K    KLI +L  E    VD  +++DF LTY +++     + + ++      S  R K   +V+ W+ NHF + E   E+   ++     L R+        +   CS  +  R V I++  KD      +VG 
Sbjct:  148 MDLRDSVRECLEKEPSERNSEDLAVLLDFMQHMSAFAALPMSIKRQLCLKMVFAVVNDAGTVVLAHNEKLDSWSVIVNGCVEV---VKPSGERVEYKLGD---------SFGAEPTPAT-QIHIGEMRTMVDDCEFVLVEHRDFCSIMS----TIGDHIEKDRDGLTGEVVSEVERRTV--GTHCGQVLIKGKPDKLIHHLVDERDHNVDPHYVDDFLLTYRVFIRDPTTIFEKLMLWFAD-SIYRDKVARLVLLWVNNHFNDFETNDEMWNLLERFEGALERDGMHSQLSLLNIACSVKAKPRQV-ILTRRKDDKMMMRLVGG 450

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Celegans
Match: pxf-1 (Rap guanine nucleotide exchange factor [Source:UniProtKB/Swiss-Prot;Acc:G5EDB9])

HSP 1 Score: 156.377 bits (394), Expect = 8.032e-38
Identity = 126/467 (26.98%), Postives = 216/467 (46.25%), Query Frame = 2

Query: 2558 VIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRS--LHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNL---LYD-CSINSSKAITSTENLLPEN--EGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPR 3934
            V+K+Y  D T             YL + KET A  V+  +L E N++   + E+ LCE +V    +IKQ+ +     NL   + LN+R+++K    S  L+ +    E+  E       L    +A Q+ ++ ++ F  I  +E +D                             NL   D K  S    +EF +L  + M++V   +C+E +   KR K++K+ I++AR C++L N    F++M+GLD+  + RL ++W+RV +K ++M  ++ QL+D S NM   R      + +PPV+P+  ++ KDLT  ++ + T              +E LINF+KLR++A   R    L    Y+  S+         + LL  N  E + +A +R            KG+S  QN            KK+YE  +   +VK ++  +  ++ ++  L +MSY  EP+
Sbjct:  620 VLKIYRNDQTFK-----------YLPVYKETSAQNVVQLALQEFNMTAEGSPEWSLCECTVTIDGVIKQRRLPPQMENLAERIALNSRYYLKNNSRSEPLVPDELAPELLKEAQTQLLSLNAQVVAAQLTLQDFSVFSAIEPTEFLD-----------------------------NLFKLDSKYGS-PKLEEFEQLFNREMWWVATEICTERH-VQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLHSSWERVSSKYIRMLDEIHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDGNATY-------------SEKLINFEKLRLIAKSIRGVMKLSSAPYEIASMAERSGGVVMDALLHMNSFENSNVATMR------------KGMSGKQNQPR---------KKVYEQALMVRKVKSYLEGLHVVD-NEMELDSMSYDIEPQ 1009

HSP 2 Score: 99.3673 bits (246), Expect = 1.952e-20
Identity = 80/324 (24.69%), Postives = 150/324 (46.30%), Query Frame = 2

Query:  779 ISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNK------TVMIMERRCSADGSTKGQVLVKATVRKLIEYLF-ENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGN 1729
            +  +D +++ L+K  ++R++++  V+++ +Q++  F+    S++   C      VV +  TV++  +EK+  W   + G +EV   V+   +  +  L D         SFGA+   +  QI    + +  +DC  +L+  ++F  I S    T+   IE ++       V  +ERR    G+  GQVL+K    KLI +L  E    VD  +++DF LTY +++     + + ++      S  R K   +V+ W+ NHF + E   E+   ++     L R+        +   CS  +  R V I++  KD      +VG 
Sbjct:  148 MDLRDSVRECLEKEPSERNSEDLAVLLDFMQHMSAFAALPMSIKRQLCLKMVFAVVNDAGTVVLAHNEKLDSWSVIVNGCVEV---VKPSGERVEYKLGD---------SFGAEPTPAT-QIHIGEMRTMVDDCEFVLVEHRDFCSIMS----TIGDHIEKDRDGLTGEVVSEVERRTV--GTHCGQVLIKGKPDKLIHHLVDERDHNVDPHYVDDFLLTYRVFIRDPTTIFEKLMLWFAD-SIYRDKVARLVLLWVNNHFNDFETNDEMWNLLERFEGALERDGMHSQLSLLNIACSVKAKPRQV-ILTRRKDDKMMMRLVGG 450

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Celegans
Match: pxf-1 (Rap guanine nucleotide exchange factor [Source:UniProtKB/Swiss-Prot;Acc:G5EDB9])

HSP 1 Score: 155.992 bits (393), Expect = 9.900e-38
Identity = 121/444 (27.25%), Postives = 209/444 (47.07%), Query Frame = 2

Query: 2627 YLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRS--LHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNL---LYD-CSINSSKAITSTENLLPEN--EGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPR 3934
            YL + KET A  V+  +L E N++   + E+ LCE +V    +IKQ+ +     NL   + LN+R+++K    S  L+ +    E+  E       L    +A Q+ ++ ++ F  I  +E +D                             NL   D K  S    +EF +L  + M++V   +C+E +   KR K++K+ I++AR C++L N    F++M+GLD+  + RL ++W+RV +K ++M  ++ QL+D S NM   R      + +PPV+P+  ++ KDLT  ++ + T              +E LINF+KLR++A   R    L    Y+  S+         + LL  N  E + +A +R            KG+S  QN            KK+YE  +   +VK ++  +  ++ ++  L +MSY  EP+
Sbjct:  797 YLPVYKETSAQNVVQLALQEFNMTAEGSPEWSLCECTVTIDGVIKQRRLPPQMENLAERIALNSRYYLKNNSRSEPLVPDELAPELLKEAQTQLLSLNAQVVAAQLTLQDFSVFSAIEPTEFLD-----------------------------NLFKLDSKYGS-PKLEEFEQLFNREMWWVATEICTERH-VQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLHSSWERVSSKYIRMLDEIHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDGNATY-------------SEKLINFEKLRLIAKSIRGVMKLSSAPYEIASMAERSGGVVMDALLHMNSFENSNVATMR------------KGMSGKQNQPR---------KKVYEQALMVRKVKSYLEGLHVVD-NEMELDSMSYDIEPQ 1174

HSP 2 Score: 99.7525 bits (247), Expect = 1.726e-20
Identity = 80/324 (24.69%), Postives = 150/324 (46.30%), Query Frame = 2

Query:  779 ISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNK------TVMIMERRCSADGSTKGQVLVKATVRKLIEYLF-ENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGN 1729
            +  +D +++ L+K  ++R++++  V+++ +Q++  F+    S++   C      VV +  TV++  +EK+  W   + G +EV   V+   +  +  L D         SFGA+   +  QI    + +  +DC  +L+  ++F  I S    T+   IE ++       V  +ERR    G+  GQVL+K    KLI +L  E    VD  +++DF LTY +++     + + ++      S  R K   +V+ W+ NHF + E   E+   ++     L R+        +   CS  +  R V I++  KD      +VG 
Sbjct:  313 MDLRDSVRECLEKEPSERNSEDLAVLLDFMQHMSAFAALPMSIKRQLCLKMVFAVVNDAGTVVLAHNEKLDSWSVIVNGCVEV---VKPSGERVEYKLGD---------SFGAEPTPAT-QIHIGEMRTMVDDCEFVLVEHRDFCSIMS----TIGDHIEKDRDGLTGEVVSEVERRTV--GTHCGQVLIKGKPDKLIHHLVDERDHNVDPHYVDDFLLTYRVFIRDPTTIFEKLMLWFAD-SIYRDKVARLVLLWVNNHFNDFETNDEMWNLLERFEGALERDGMHSQLSLLNIACSVKAKPRQV-ILTRRKDDKMMMRLVGG 615

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Fly
Match: PDZ-GEF (gene:FBgn0265778 transcript:FBtr0079249)

HSP 1 Score: 167.548 bits (423), Expect = 4.891e-41
Identity = 133/459 (28.98%), Postives = 229/459 (49.89%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKS---CKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLL---YD-CSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRR--SACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   + + K++    Y++I KET A EV++ +L E  +   S S F LCE+SV  G ++KQ+ + +   NL   +    R+++K  D +  L+ +    E+  E NV F  L   ELA Q+ ++ +  F++I  +E +D +                            L +R G    V    +F +L  + M++VV+ +C+E N   +R KI+K+ I++AR CKE  N    F++++GL    +SRLR TW+++P+K  +++  +Q L+D S NM   R L  +    + P+IP   +V KDLT I+  + T+V  DG           LINF+KLR++A   R   ++    YD  SI   K  + +  L   N   Q++  +   +   +  ++ G +T    + RR+  +A  N KK++E      RVK ++  ++ +  +D +L   S +CEP
Sbjct:  757 PDHVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPS-SNFSLCEVSVGDGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELF--------------------------ELRSRYG----VPMLSKFAELVNREMFWVVSEICAEHN-IVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRV--DG-----------LINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLN---QMSASQSNAAAGTVIAANAGQAT----IKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDED-LLHKFSLECEP 1162

HSP 2 Score: 134.806 bits (338), Expect = 3.995e-31
Identity = 106/447 (23.71%), Postives = 207/447 (46.31%), Query Frame = 2

Query:  767 TFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQ-EPTTLTQIIENNKTVMIMERRC-------------SADGST------KGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYL-----TSTVLVRKAIIEQIP--RVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGN----GSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGF 1999
            + + ++ +D ++D L+K  A+RS ++ EV++   Q +  F+  T ++R A C +    VV+   TV++   E++  W   + G +E+    E+ N +         E L+  DSFG  L   ++   +  + +  +DC  + I   ++ +I+ Q E  T     EN   VM+ E R              SA G++      +G V+++ T  +L++ L E +   D T++EDF LT+ +++      ++ L+    +EQ+   +  E R + T +V+ W+ NHF + E   E+M+F++    LL R+        ++  C+  +  R+ T+  + +D+     IVG     G  I++ + A+                        ++IS +   S      L  GD++ ++N  S +++T K A  IL+ +    ++VK +  GF
Sbjct:   90 SMDSLTVRDAVRDCLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVVMSDGEELDSWSVLINGAVEI----EHANGSR--------EELQMGDSFGI-LPTMDKLYHRGVMRTKCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQQLVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLSQLRLLHIACAAKARMRSCTLTRSSRDEPLNFRIVGGYELRGVAIATGNAAV-----------------------GIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGF 500

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Fly
Match: PDZ-GEF (gene:FBgn0265778 transcript:FBtr0333242)

HSP 1 Score: 166.777 bits (421), Expect = 8.113e-41
Identity = 133/459 (28.98%), Postives = 229/459 (49.89%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKS---CKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLL---YD-CSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRR--SACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   + + K++    Y++I KET A EV++ +L E  +   S S F LCE+SV  G ++KQ+ + +   NL   +    R+++K  D +  L+ +    E+  E NV F  L   ELA Q+ ++ +  F++I  +E +D +                            L +R G    V    +F +L  + M++VV+ +C+E N   +R KI+K+ I++AR CKE  N    F++++GL    +SRLR TW+++P+K  +++  +Q L+D S NM   R L  +    + P+IP   +V KDLT I+  + T+V  DG           LINF+KLR++A   R   ++    YD  SI   K  + +  L   N   Q++  +   +   +  ++ G +T    + RR+  +A  N KK++E      RVK ++  ++ +  +D +L   S +CEP
Sbjct:  757 PDHVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPS-SNFSLCEVSVGDGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELF--------------------------ELRSRYG----VPMLSKFAELVNREMFWVVSEICAEHN-IVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRV--DG-----------LINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLN---QMSASQSNAAAGTVIAANAGQAT----IKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDED-LLHKFSLECEP 1162

HSP 2 Score: 134.806 bits (338), Expect = 4.452e-31
Identity = 106/447 (23.71%), Postives = 207/447 (46.31%), Query Frame = 2

Query:  767 TFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQ-EPTTLTQIIENNKTVMIMERRC-------------SADGST------KGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYL-----TSTVLVRKAIIEQIP--RVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGN----GSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGF 1999
            + + ++ +D ++D L+K  A+RS ++ EV++   Q +  F+  T ++R A C +    VV+   TV++   E++  W   + G +E+    E+ N +         E L+  DSFG  L   ++   +  + +  +DC  + I   ++ +I+ Q E  T     EN   VM+ E R              SA G++      +G V+++ T  +L++ L E +   D T++EDF LT+ +++      ++ L+    +EQ+   +  E R + T +V+ W+ NHF + E   E+M+F++    LL R+        ++  C+  +  R+ T+  + +D+     IVG     G  I++ + A+                        ++IS +   S      L  GD++ ++N  S +++T K A  IL+ +    ++VK +  GF
Sbjct:   90 SMDSLTVRDAVRDCLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVVMSDGEELDSWSVLINGAVEI----EHANGSR--------EELQMGDSFGI-LPTMDKLYHRGVMRTKCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQQLVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLSQLRLLHIACAAKARMRSCTLTRSSRDEPLNFRIVGGYELRGVAIATGNAAV-----------------------GIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGF 500

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Fly
Match: PDZ-GEF (gene:FBgn0265778 transcript:FBtr0300038)

HSP 1 Score: 166.777 bits (421), Expect = 8.113e-41
Identity = 133/459 (28.98%), Postives = 229/459 (49.89%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKS---CKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLL---YD-CSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRR--SACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   + + K++    Y++I KET A EV++ +L E  +   S S F LCE+SV  G ++KQ+ + +   NL   +    R+++K  D +  L+ +    E+  E NV F  L   ELA Q+ ++ +  F++I  +E +D +                            L +R G    V    +F +L  + M++VV+ +C+E N   +R KI+K+ I++AR CKE  N    F++++GL    +SRLR TW+++P+K  +++  +Q L+D S NM   R L  +    + P+IP   +V KDLT I+  + T+V  DG           LINF+KLR++A   R   ++    YD  SI   K  + +  L   N   Q++  +   +   +  ++ G +T    + RR+  +A  N KK++E      RVK ++  ++ +  +D +L   S +CEP
Sbjct:  757 PDHVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPS-SNFSLCEVSVGDGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELF--------------------------ELRSRYG----VPMLSKFAELVNREMFWVVSEICAEHN-IVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRV--DG-----------LINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLN---QMSASQSNAAAGTVIAANAGQAT----IKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDED-LLHKFSLECEP 1162

HSP 2 Score: 134.806 bits (338), Expect = 4.452e-31
Identity = 106/447 (23.71%), Postives = 207/447 (46.31%), Query Frame = 2

Query:  767 TFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQ-EPTTLTQIIENNKTVMIMERRC-------------SADGST------KGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYL-----TSTVLVRKAIIEQIP--RVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGN----GSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGF 1999
            + + ++ +D ++D L+K  A+RS ++ EV++   Q +  F+  T ++R A C +    VV+   TV++   E++  W   + G +E+    E+ N +         E L+  DSFG  L   ++   +  + +  +DC  + I   ++ +I+ Q E  T     EN   VM+ E R              SA G++      +G V+++ T  +L++ L E +   D T++EDF LT+ +++      ++ L+    +EQ+   +  E R + T +V+ W+ NHF + E   E+M+F++    LL R+        ++  C+  +  R+ T+  + +D+     IVG     G  I++ + A+                        ++IS +   S      L  GD++ ++N  S +++T K A  IL+ +    ++VK +  GF
Sbjct:   90 SMDSLTVRDAVRDCLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVVMSDGEELDSWSVLINGAVEI----EHANGSR--------EELQMGDSFGI-LPTMDKLYHRGVMRTKCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQQLVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLSQLRLLHIACAAKARMRSCTLTRSSRDEPLNFRIVGGYELRGVAIATGNAAV-----------------------GIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGF 500

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Fly
Match: PDZ-GEF (gene:FBgn0265778 transcript:FBtr0300039)

HSP 1 Score: 166.392 bits (420), Expect = 9.380e-41
Identity = 133/459 (28.98%), Postives = 229/459 (49.89%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKS---CKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLL---YD-CSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRR--SACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   + + K++    Y++I KET A EV++ +L E  +   S S F LCE+SV  G ++KQ+ + +   NL   +    R+++K  D +  L+ +    E+  E NV F  L   ELA Q+ ++ +  F++I  +E +D +                            L +R G    V    +F +L  + M++VV+ +C+E N   +R KI+K+ I++AR CKE  N    F++++GL    +SRLR TW+++P+K  +++  +Q L+D S NM   R L  +    + P+IP   +V KDLT I+  + T+V  DG           LINF+KLR++A   R   ++    YD  SI   K  + +  L   N   Q++  +   +   +  ++ G +T    + RR+  +A  N KK++E      RVK ++  ++ +  +D +L   S +CEP
Sbjct:  757 PDHVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPS-SNFSLCEVSVGDGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELF--------------------------ELRSRYG----VPMLSKFAELVNREMFWVVSEICAEHN-IVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRV--DG-----------LINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLN---QMSASQSNAAAGTVIAANAGQAT----IKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDED-LLHKFSLECEP 1162

HSP 2 Score: 134.806 bits (338), Expect = 4.094e-31
Identity = 106/447 (23.71%), Postives = 207/447 (46.31%), Query Frame = 2

Query:  767 TFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQ-EPTTLTQIIENNKTVMIMERRC-------------SADGST------KGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYL-----TSTVLVRKAIIEQIP--RVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGN----GSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGF 1999
            + + ++ +D ++D L+K  A+RS ++ EV++   Q +  F+  T ++R A C +    VV+   TV++   E++  W   + G +E+    E+ N +         E L+  DSFG  L   ++   +  + +  +DC  + I   ++ +I+ Q E  T     EN   VM+ E R              SA G++      +G V+++ T  +L++ L E +   D T++EDF LT+ +++      ++ L+    +EQ+   +  E R + T +V+ W+ NHF + E   E+M+F++    LL R+        ++  C+  +  R+ T+  + +D+     IVG     G  I++ + A+                        ++IS +   S      L  GD++ ++N  S +++T K A  IL+ +    ++VK +  GF
Sbjct:   90 SMDSLTVRDAVRDCLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVVMSDGEELDSWSVLINGAVEI----EHANGSR--------EELQMGDSFGI-LPTMDKLYHRGVMRTKCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQQLVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLSQLRLLHIACAAKARMRSCTLTRSSRDEPLNFRIVGGYELRGVAIATGNAAV-----------------------GIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGF 500

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Fly
Match: Epac (gene:FBgn0085421 transcript:FBtr0112636)

HSP 1 Score: 103.99 bits (258), Expect = 7.919e-22
Identity = 75/287 (26.13%), Postives = 139/287 (48.43%), Query Frame = 2

Query: 2759 KQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFK 3619
            ++ + K+N  ++ + + LN R F+  +D    L    + E     +++    L   ELA  I +  ++ F  +   E++    G+      ++  K          I  NLD              FL+   +  Y++V  + S T S SKR  ++++ I++A  CKE  N+  FF+++ GL  + +SRL+ TW+++P+K  K++++ + L+D S N R  R      +PP+IP   L+ KD+T  +E + T +  DG           L+NF+K+ +MA   R+ +
Sbjct:  569 ERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGR------HHFGK----------ITANLD-------------VFLRRFNEVQYWIVTELVS-TPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQPPLIPFMPLLLKDMTFAHEGNKTSL--DG-----------LVNFEKMHMMAQTMRTIR 812

HSP 2 Score: 53.1434 bits (126), Expect = 2.811e-6
Identity = 50/225 (22.22%), Postives = 103/225 (45.78%), Query Frame = 2

Query:  797 IKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERRCSADG--STKGQVLVKATVRKLIEYLFENH-----GQVDETFIEDFFLTYNMYLTSTVLV 1450
            ++ IL+KPS +R+++E E++   + +I   S  + S++     +   +      T+L  + ++   W   L+G+++V   +              + TL+  D FG  L    +      +V   N+C L+ ++ + F +I         ++ E+ K V+++ER     G  S     ++  T  K++E+L E       G +D  F++DF LT+ +++    LV
Sbjct:  179 LRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIFVFEAHAQAGTILFNQGDEGRSWYILLKGSVDV--VIHG---------KGTVATLKTGDDFG-KLALINDAPRAATIVLKENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDVLVLERVAKQRGQHSAFKYTVMSGTPAKMLEHLLETRLGQSVGGMD-PFLDDFLLTHIVFMPVVQLV 390

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Zebrafish
Match: rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6959])

HSP 1 Score: 170.244 bits (430), Expect = 8.702e-42
Identity = 125/449 (27.84%), Postives = 224/449 (49.89%), Query Frame = 2

Query: 2594 ISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKS--CKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            + + K++ +S Y++I K+T A EV+ +++ E  L+ A+ + + LCE+SV    +IKQ+ + E  S L   ++L+ R+++K    +  L  + D +E+  E +++   L   E+ATQ+ +  +  F  I  +E ID +                      F + T L        S+  F+E +    +  ++V   V  E N   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K++  +Q L D S NM   R+L  S   +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    ++N   A+                F    LS+     +   ++ +  H  R RRS+ +N KK+YE+     +VK ++  +  +E ++  L  +S +CEP
Sbjct:  780 LRVFKADQQSRYIMIGKDTTAKEVVAQAIREFALTAAAEA-YSLCEVSVTPEGVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESHISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDL----------------------FKLKTRLTG----PPSLKLFEEAIN---RETFWVATEVVREANQL-KRMKIVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNLLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---AAVNMDPALM---------------FRTRSLSQGSANAAVLDVTQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNL-TLETNEESLQTLSMQCEP 1165

HSP 2 Score: 137.502 bits (345), Expect = 8.271e-32
Identity = 103/404 (25.50%), Postives = 180/404 (44.55%), Query Frame = 2

Query:  788 QDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV            +N     E L   +SFG      E++  K  + +  +DC  + I  +++  I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L S ++V K ++E     S  R K T +V+ W+ NHF + E    +  F++     L RE    H   +   C+  +  R VT+    ++                               ++F L    +K   +FI  +   S      L  GD+++++N  + EN+   +AN IL  +    +TVK
Sbjct:  259 RDIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEV-------THPDSRN-----EILCMGNSFGVS-PTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLPSPMVVGKRLLEWFHDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTHFLEEFEYNLEREKMCGHLRLLNIACAAKAKLRVVTLTKPSREAP-----------------------------LAFTLLGGSEKGFRIFIDSVEPGSKAAEAGLKRGDQILEVNGQNFENVPLSKANEILKNNTHLSITVK 619

HSP 3 Score: 66.6254 bits (161), Expect = 3.420e-10
Identity = 36/128 (28.12%), Postives = 64/128 (50.00%), Query Frame = 2

Query:  113 SNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSTIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFY 496
            S + NS   A+  +P  R+++++EI+  YL  +  L     +   +    V+Y+  + N  +    D    WY +L GSV I  +MFLP +SF  +   +     ECIVLE + +++  Y + N  ++
Sbjct:    3 SYVDNSFRQAVMVNPSDRTQQDLEIVYSYLHGMEALSNLREHQLRIMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDYMDENEEYF 130

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Zebrafish
Match: rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6959])

HSP 1 Score: 167.933 bits (424), Expect = 4.178e-41
Identity = 124/455 (27.25%), Postives = 229/455 (50.33%), Query Frame = 2

Query: 2594 ISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            + + K++ +S Y++I K+T A EV+ +++ E  L+ A+ + + LCE+SV    +IKQ+ + E  S L   ++L+ R+++K    +  L  + D +E+  E +++   L   E+ATQ+ +  +  F  I  +E ID +                      F + T L        S+  F+E +    +  ++V   V  E N   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K++  +Q L D S NM   R+L   ++ +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    ++N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +  +E ++  L  +S +CEP
Sbjct:  632 LRVFKADQQSRYIMIGKDTTAKEVVAQAIREFALTAAAEA-YSLCEVSVTPEGVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESHISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDL----------------------FKLKTRLTG----PPSLKLFEEAIN---RETFWVATEVVREANQL-KRMKIVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNLLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---AAVNMDPALMFRTRKKKWRSLGSLSQGSANAAVLDV-------------TQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNL-TLETNEESLQTLSMQCEP 1025

HSP 2 Score: 137.502 bits (345), Expect = 9.050e-32
Identity = 103/409 (25.18%), Postives = 182/409 (44.50%), Query Frame = 2

Query:  773 NEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            + +  +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV            +N     E L   +SFG      +E + K  + +  +DC  + I  +++  I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L S ++V K ++E     S  R K T +V+ W+ NHF + E    +  F++     L RE    H   +   C+  +  R VT+    ++                               ++F L    +K   +FI  +   S      L  GD+++++N  + EN+   +AN IL  +    +TVK
Sbjct:  111 DPLMSRDIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEV-------THPDSRN-----EILCMGNSFGVSPTMEKEYM-KGVMKTKVDDCQFVCIAQQDYCCILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLPSPMVVGKRLLEWFHDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTHFLEEFEYNLEREKMCGHLRLLNIACAAKAKLRVVTLTKPSREAP-----------------------------LAFTLLGGSEKGFRIFIDSVEPGSKAAEAGLKRGDQILEVNGQNFENVPLSKANEILKNNTHLSITVK 476

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Zebrafish
Match: rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6959])

HSP 1 Score: 167.933 bits (424), Expect = 4.676e-41
Identity = 125/455 (27.47%), Postives = 228/455 (50.11%), Query Frame = 2

Query: 2594 ISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKS--CKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            + + K++ +S Y++I K+T A EV+ +++ E  L+ A+ + + LCE+SV    +IKQ+ + E  S L   ++L+ R+++K    +  L  + D +E+  E +++   L   E+ATQ+ +  +  F  I  +E ID +                      F + T L        S+  F+E +    +  ++V   V  E N   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K++  +Q L D S NM   R+L  S   +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    ++N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +  +E ++  L  +S +CEP
Sbjct:  752 LRVFKADQQSRYIMIGKDTTAKEVVAQAIREFALTAAAEA-YSLCEVSVTPEGVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESHISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDL----------------------FKLKTRLTG----PPSLKLFEEAIN---RETFWVATEVVREANQL-KRMKIVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNLLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---AAVNMDPALMFRTRKKKWRSLGSLSQGSANAAVLDV-------------TQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNL-TLETNEESLQTLSMQCEP 1145

HSP 2 Score: 137.117 bits (344), Expect = 1.033e-31
Identity = 103/404 (25.50%), Postives = 180/404 (44.55%), Query Frame = 2

Query:  788 QDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV            +N     E L   +SFG      E++  K  + +  +DC  + I  +++  I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L S ++V K ++E     S  R K T +V+ W+ NHF + E    +  F++     L RE    H   +   C+  +  R VT+    ++                               ++F L    +K   +FI  +   S      L  GD+++++N  + EN+   +AN IL  +    +TVK
Sbjct:  236 RDIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEV-------THPDSRN-----EILCMGNSFGVS-PTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLPSPMVVGKRLLEWFHDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTHFLEEFEYNLEREKMCGHLRLLNIACAAKAKLRVVTLTKPSREAP-----------------------------LAFTLLGGSEKGFRIFIDSVEPGSKAAEAGLKRGDQILEVNGQNFENVPLSKANEILKNNTHLSITVK 596

HSP 3 Score: 58.151 bits (139), Expect = 1.328e-7
Identity = 30/107 (28.04%), Postives = 52/107 (48.60%), Query Frame = 2

Query:  176 NIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSTIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFY 496
            ++EI+  YL  +  L     +   +    V+Y+  + N  +    D    WY +L GSV I  +MFLP +SF  +   +     ECIVLE + +++  Y + N  ++
Sbjct:    1 DLEIVYSYLHGMEALSNLREHQLRIMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDYMDENEEYF 107

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Zebrafish
Match: rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6959])

HSP 1 Score: 167.933 bits (424), Expect = 4.915e-41
Identity = 125/455 (27.47%), Postives = 228/455 (50.11%), Query Frame = 2

Query: 2594 ISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKS--CKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            + + K++ +S Y++I K+T A EV+ +++ E  L+ A+ + + LCE+SV    +IKQ+ + E  S L   ++L+ R+++K    +  L  + D +E+  E +++   L   E+ATQ+ +  +  F  I  +E ID +                      F + T L        S+  F+E +    +  ++V   V  E N   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K++  +Q L D S NM   R+L  S   +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    ++N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +  +E ++  L  +S +CEP
Sbjct:  793 LRVFKADQQSRYIMIGKDTTAKEVVAQAIREFALTAAAEA-YSLCEVSVTPEGVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESHISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDL----------------------FKLKTRLTG----PPSLKLFEEAIN---RETFWVATEVVREANQL-KRMKIVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNLLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---AAVNMDPALMFRTRKKKWRSLGSLSQGSANAAVLDV-------------TQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNL-TLETNEESLQTLSMQCEP 1186

HSP 2 Score: 137.502 bits (345), Expect = 9.791e-32
Identity = 103/404 (25.50%), Postives = 180/404 (44.55%), Query Frame = 2

Query:  788 QDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV            +N     E L   +SFG      E++  K  + +  +DC  + I  +++  I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L S ++V K ++E     S  R K T +V+ W+ NHF + E    +  F++     L RE    H   +   C+  +  R VT+    ++                               ++F L    +K   +FI  +   S      L  GD+++++N  + EN+   +AN IL  +    +TVK
Sbjct:  277 RDIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEV-------THPDSRN-----EILCMGNSFGVS-PTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLPSPMVVGKRLLEWFHDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTHFLEEFEYNLEREKMCGHLRLLNIACAAKAKLRVVTLTKPSREAP-----------------------------LAFTLLGGSEKGFRIFIDSVEPGSKAAEAGLKRGDQILEVNGQNFENVPLSKANEILKNNTHLSITVK 637

HSP 3 Score: 66.6254 bits (161), Expect = 3.637e-10
Identity = 36/128 (28.12%), Postives = 64/128 (50.00%), Query Frame = 2

Query:  113 SNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSTIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFY 496
            S + NS   A+  +P  R+++++EI+  YL  +  L     +   +    V+Y+  + N  +    D    WY +L GSV I  +MFLP +SF  +   +     ECIVLE + +++  Y + N  ++
Sbjct:    3 SYVDNSFRQAVMVNPSDRTQQDLEIVYSYLHGMEALSNLREHQLRIMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDYMDENEEYF 130

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Zebrafish
Match: rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6959])

HSP 1 Score: 167.548 bits (423), Expect = 5.303e-41
Identity = 125/455 (27.47%), Postives = 228/455 (50.11%), Query Frame = 2

Query: 2594 ISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKS--CKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            + + K++ +S Y++I K+T A EV+ +++ E  L+ A+ + + LCE+SV    +IKQ+ + E  S L   ++L+ R+++K    +  L  + D +E+  E +++   L   E+ATQ+ +  +  F  I  +E ID +                      F + T L        S+  F+E +    +  ++V   V  E N   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K++  +Q L D S NM   R+L  S   +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    ++N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +  +E ++  L  +S +CEP
Sbjct:  622 LRVFKADQQSRYIMIGKDTTAKEVVAQAIREFALTAAAEA-YSLCEVSVTPEGVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESHISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDL----------------------FKLKTRLTG----PPSLKLFEEAIN---RETFWVATEVVREANQL-KRMKIVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNLLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---AAVNMDPALMFRTRKKKWRSLGSLSQGSANAAVLDV-------------TQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNL-TLETNEESLQTLSMQCEP 1015

HSP 2 Score: 137.117 bits (344), Expect = 1.161e-31
Identity = 103/404 (25.50%), Postives = 180/404 (44.55%), Query Frame = 2

Query:  788 QDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV            +N     E L   +SFG      E++  K  + +  +DC  + I  +++  I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L S ++V K ++E     S  R K T +V+ W+ NHF + E    +  F++     L RE    H   +   C+  +  R VT+    ++                               ++F L    +K   +FI  +   S      L  GD+++++N  + EN+   +AN IL  +    +TVK
Sbjct:  106 RDIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEV-------THPDSRN-----EILCMGNSFGVS-PTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLPSPMVVGKRLLEWFHDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTHFLEEFEYNLEREKMCGHLRLLNIACAAKAKLRVVTLTKPSREAP-----------------------------LAFTLLGGSEKGFRIFIDSVEPGSKAAEAGLKRGDQILEVNGQNFENVPLSKANEILKNNTHLSITVK 466

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Xenopus
Match: rapgef2 (cathepsin K-like [Source:Xenbase;Acc:XB-GENE-986812])

HSP 1 Score: 280.796 bits (717), Expect = 1.138e-75
Identity = 262/1057 (24.79%), Postives = 467/1057 (44.18%), Query Frame = 2

Query:  788 QDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKS--CKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   TV++   E++  W   L G++EV                   E L   +SFG      E++  K  + +  +DC  + I  +++ +I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L+S + V K ++E     S  R K T +V+ W+ NHF + E    + +F++     L RE    H   +   C+  + +R +T+    ++                               + FNL     K   +F+  +   S      L  GD+++++N  + EN+   +A  IL  +    LTVK +   F    L   L+ K  S                           P  PK+G I    +   +  +P+          L+K+ K+ KAN+     K +K   K+R +           P   +N    D+ I  +   +        ++ A  P        +   S PDL +S                     + P   + + K++ +S Y++ISK+T A EV+++++ E  L+   ++ + LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +++  E  ++   L   E+ATQ+ +  +  F+ I  +E ID +  KL+ ++                  TNL           NF+E +    +  ++V + +  ETN   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K+++ +Q L D S NM   R++  S   +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+                F    LS+     +   ++ S  H  R RRS+ +N KK+YE+     +VK ++  ++ +E D+  L  +S +CEP
Sbjct:  216 RDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTVVLNDGEELDSWSVILNGSVEVTYP------------DGRTEILCMGNSFGVS-PTMEKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMEVGKKLLEWFNDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLITLTKPSREAP-----------------------------LPFNLLGGSDKGFGIFVDSVDPGSKAAETGLKRGDQILEVNGQNFENIQLTKALEILRNNTHLSLTVKTNLFVF-KELLARMLEEKRNSA--------------------------PHLPKIGDI----KKASRYSIPDLAVDVEQVIGLEKVSKKGKANTVGGRNKLKKILDKTRIS---------ILPQKPYN----DIGIGQSQDDSIVGLRQTKHMPATLPVSG-----TLSSSNPDLLQSHHRILD----------FNTTPEQPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFALTAVPDA-YSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQDLLRESQISLLQLSTIEVATQLSMRNFELFRNIEPTEYIDDLF-KLKMKTGC----------------TNL----------KNFEEVIN---QETFWVASEILRETNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRTTWEKLPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALM---------------FRTRSLSQGSTNATVLDVAQSGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSDLD-LEMDEENLQTLSVQCEP 1106

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Xenopus
Match: rapgef2 (cathepsin K-like [Source:Xenbase;Acc:XB-GENE-986812])

HSP 1 Score: 280.026 bits (715), Expect = 1.773e-75
Identity = 264/1077 (24.51%), Postives = 473/1077 (43.92%), Query Frame = 2

Query:  773 NEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPD-LRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKS--CKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVSRA 3973
            + +  +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   TV++   E++  W   L G++EV                   E L   +SFG      E++  K  + +  +DC  + I  +++ +I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L+S + V K ++E     S  R K T +V+ W+ NHF + E    + +F++     L RE    H   +   C+  + +R +T+    ++                               + FNL     K   +F+  +   S      L  GD+++++N  + EN+   +A  IL  +    LTVK +    +   L   L+ K  S                           P  PK+G I    +   +  +P+          L+K+ K+ KAN+     K +K   K+R +           P   +N    D+ I  +   +        ++ A  P        +   S PD L+          +    + V++V+  D            +S Y++ISK+T A EV+++++ E  L+   ++ + LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +++  E  ++   L   E+ATQ+ +  +  F+ I  +E ID +  KL+ ++                  TNL           NF+E +    +  ++V + +  ETN   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K+++ +Q L D S NM   R++  S   +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+                F    LS+     +   ++ S  H  R RRS+ +N KK+YE+     +VK ++  ++ +E D+  L  +S +CEP +      P   RA
Sbjct:  207 DPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTVVLNDGEELDSWSVILNGSVEVTYP------------DGRTEILCMGNSFGVS-PTMEKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMEVGKKLLEWFNDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLITLTKPSREAP-----------------------------LPFNLLGGSDKGFGIFVDSVDPGSKAAETGLKRGDQILEVNGQNFENIQLTKALEILRNNTHLSLTVKTN-LFVFKELLARMLEEKRNS--------------------------APHLPKIGDI----KKASRYSIPDLAVDVEQVIGLEKVSKKGKANTVGGRNKLKKILDKTRIS---------ILPQKPYN----DIGIGQSQDDSIVGLRQTKHMPATLPVSG-----TLSSSNPDLLQSHHRILDFNTTPEQPDQVLRVFKAD-----------QQSRYIMISKDTTAKEVVIQAIREFALTAVPDA-YSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQDLLRESQISLLQLSTIEVATQLSMRNFELFRNIEPTEYIDDLF-KLKMKTG----------------CTNL----------KNFEEVIN---QETFWVASEILRETNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRTTWEKLPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALM---------------FRTRSLSQGSTNATVLDVAQSGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSDLD-LEMDEENLQTLSVQCEPATNTLPKNPCEKRA 1116

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Xenopus
Match: rapgef2 (cathepsin K-like [Source:Xenbase;Acc:XB-GENE-986812])

HSP 1 Score: 280.411 bits (716), Expect = 1.929e-75
Identity = 264/1077 (24.51%), Postives = 475/1077 (44.10%), Query Frame = 2

Query:  788 QDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKS--CKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVSRA 3973
            +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   TV++   E++  W   L G++EV                   E L   +SFG      E++  K  + +  +DC  + I  +++ +I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L+S + V K ++E     S  R K T +V+ W+ NHF + E    + +F++     L RE    H   +   C+  + +R +T+    ++                               + FNL     K   +F+  +   S      L  GD+++++N  + EN+   +A  IL  +    LTVK +    +   L   L+ K  S                           P  PK+G I    +   +  +P+          L+K+ K+ KAN+     K +K   K+R +           P   +N    D+ I  +   +        ++ A  P        +   S PDL +S                     + P   + + K++ +S Y++ISK+T A EV+++++ E  L+   ++ + LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +++  E  ++   L   E+ATQ+ +  +  F+ I  +E ID +  KL+ ++                  TNL           NF+E +    +  ++V + +  ETN   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K+++ +Q L D S NM   R++  S   +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+          +L   ++G+  A + ++             + S  H  R RRS+ +N KK+YE+     +VK ++  ++ +E D+  L  +S +CEP +      P   RA
Sbjct:  258 RDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTVVLNDGEELDSWSVILNGSVEVTYP------------DGRTEILCMGNSFGVS-PTMEKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMEVGKKLLEWFNDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLITLTKPSREAP-----------------------------LPFNLLGGSDKGFGIFVDSVDPGSKAAETGLKRGDQILEVNGQNFENIQLTKALEILRNNTHLSLTVKTN-LFVFKELLARMLEEKRNS--------------------------APHLPKIGDI----KKASRYSIPDLAVDVEQVIGLEKVSKKGKANTVGGRNKLKKILDKTRIS---------ILPQKPYN----DIGIGQSQDDSIVGLRQTKHMPATLPVSG-----TLSSSNPDLLQSHHRILD----------FNTTPEQPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFALTAVPDA-YSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQDLLRESQISLLQLSTIEVATQLSMRNFELFRNIEPTEYIDDLF-KLKMKTG----------------CTNL----------KNFEEVIN---QETFWVASEILRETNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRTTWEKLPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDV-------------AQSGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSDLD-LEMDEENLQTLSVQCEPATNTLPKNPCEKRA 1170

HSP 2 Score: 59.6918 bits (143), Expect = 6.620e-8
Identity = 31/109 (28.44%), Postives = 54/109 (49.54%), Query Frame = 2

Query:  170 KENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSTIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFY 496
            ++++EI+  YL  +  L     +   L    V+Y+  + N  +    D    WY +L GSV I  +MFLP +SF  +   +     ECIVLE + +++  Y + N  ++
Sbjct:   21 RKDLEIVYSYLHGMEALSNLREHQLRLMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDYMDENEEYF 129

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Xenopus
Match: rapgef2 (cathepsin K-like [Source:Xenbase;Acc:XB-GENE-986812])

HSP 1 Score: 280.026 bits (715), Expect = 2.211e-75
Identity = 264/1072 (24.63%), Postives = 471/1072 (43.94%), Query Frame = 2

Query:  788 QDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPD-LRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKS--CKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVSRA 3973
            +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   TV++   E++  W   L G++EV                   E L   +SFG      E++  K  + +  +DC  + I  +++ +I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L+S + V K ++E     S  R K T +V+ W+ NHF + E    + +F++     L RE    H   +   C+  + +R +T+    ++                               + FNL     K   +F+  +   S      L  GD+++++N  + EN+   +A  IL  +    LTVK +    +   L   L+ K  S                           P  PK+G I    +   +  +P+          L+K+ K+ KAN+     K +K   K+R +           P   +N    D+ I  +   +        ++ A  P        +   S PD L+          +    + V++V+  D            +S Y++ISK+T A EV+++++ E  L+   ++ + LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +++  E  ++   L   E+ATQ+ +  +  F+ I  +E ID +  KL+ ++                  TNL           NF+E +    +  ++V + +  ETN   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K+++ +Q L D S NM   R++  S   +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+                F    LS+     +   ++ S  H  R RRS+ +N KK+YE+     +VK ++  ++ +E D+  L  +S +CEP +      P   RA
Sbjct:  265 RDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTVVLNDGEELDSWSVILNGSVEVTYP------------DGRTEILCMGNSFGVS-PTMEKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMEVGKKLLEWFNDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLITLTKPSREAP-----------------------------LPFNLLGGSDKGFGIFVDSVDPGSKAAETGLKRGDQILEVNGQNFENIQLTKALEILRNNTHLSLTVKTN-LFVFKELLARMLEEKRNS--------------------------APHLPKIGDI----KKASRYSIPDLAVDVEQVIGLEKVSKKGKANTVGGRNKLKKILDKTRIS---------ILPQKPYN----DIGIGQSQDDSIVGLRQTKHMPATLPVSG-----TLSSSNPDLLQSHHRILDFNTTPEQPDQVLRVFKAD-----------QQSRYIMISKDTTAKEVVIQAIREFALTAVPDA-YSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQDLLRESQISLLQLSTIEVATQLSMRNFELFRNIEPTEYIDDLF-KLKMKTGC----------------TNL----------KNFEEVIN---QETFWVASEILRETNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRTTWEKLPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALM---------------FRTRSLSQGSTNATVLDVAQSGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSDLD-LEMDEENLQTLSVQCEPATNTLPKNPCEKRA 1169

HSP 2 Score: 68.1662 bits (165), Expect = 1.571e-10
Identity = 38/128 (29.69%), Postives = 63/128 (49.22%), Query Frame = 2

Query:  113 SNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSTIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFY 496
            S + NS   A+ + P  RS +++EI+  YL  +  L     +   L    V+Y+  + N  +    D    WY +L GSV I  +MFLP +SF  +   +     ECIVLE + +++  Y + N  ++
Sbjct:    3 SYVDNSFRQAVMKPPADRSAQDLEIVYSYLHGMEALSNLREHQLRLMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDYMDENEEYF 130

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Xenopus
Match: rapgef2 (cathepsin K-like [Source:Xenbase;Acc:XB-GENE-986812])

HSP 1 Score: 279.641 bits (714), Expect = 2.597e-75
Identity = 263/1077 (24.42%), Postives = 474/1077 (44.01%), Query Frame = 2

Query:  773 NEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPD-LRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVSRA 3973
            + +  +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   TV++   E++  W   L G++EV                   E L   +SFG      E++  K  + +  +DC  + I  +++ +I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L+S + V K ++E     S  R K T +V+ W+ NHF + E    + +F++     L RE    H   +   C+  + +R +T+    ++                               + FNL     K   +F+  +   S      L  GD+++++N  + EN+   +A  IL  +    LTVK +    +   L   L+ K  S                           P  PK+G I    +   +  +P+          L+K+ K+ KAN+     K +K   K+R +           P   +N    D+ I  +   +        ++ A  P        +   S PD L+          +    + V++V+  D            +S Y++ISK+T A EV+++++ E  L+   ++ + LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +++  E  ++   L   E+ATQ+ +  +  F+ I  +E ID +  KL+ ++                  TNL           NF+E +    +  ++V + +  ETN   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K+++ +Q L D S NM   R++   ++ +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+                F    LS+     +   ++ S  H  R RRS+ +N KK+YE+     +VK ++  ++ +E D+  L  +S +CEP +      P   RA
Sbjct:  132 DPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTVVLNDGEELDSWSVILNGSVEVTYP------------DGRTEILCMGNSFGVS-PTMEKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMEVGKKLLEWFNDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLITLTKPSREAP-----------------------------LPFNLLGGSDKGFGIFVDSVDPGSKAAETGLKRGDQILEVNGQNFENIQLTKALEILRNNTHLSLTVKTN-LFVFKELLARMLEEKRNS--------------------------APHLPKIGDI----KKASRYSIPDLAVDVEQVIGLEKVSKKGKANTVGGRNKLKKILDKTRIS---------ILPQKPYN----DIGIGQSQDDSIVGLRQTKHMPATLPVSG-----TLSSSNPDLLQSHHRILDFNTTPEQPDQVLRVFKAD-----------QQSRYIMISKDTTAKEVVIQAIREFALTAVPDA-YSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQDLLRESQISLLQLSTIEVATQLSMRNFELFRNIEPTEYIDDLF-KLKMKTG----------------CTNL----------KNFEEVIN---QETFWVASEILRETNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRTTWEKLPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALM---------------FRTRSLSQGSTNATVLDVAQSGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSDLD-LEMDEENLQTLSVQCEPATNTLPKNPCEKRA 1041

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Mouse
Match: Rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:MGI Symbol;Acc:MGI:2659071])

HSP 1 Score: 177.178 bits (448), Expect = 6.566e-44
Identity = 126/459 (27.45%), Postives = 238/459 (51.85%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   + + K++ +S Y++ISK+T A EV+++++ E  ++ A+  ++ LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  +  F+ I  +E ID +  KL+ ++                             S  N ++F ++  +  ++V + +  ETN   KR KI+K  I++A  C+E  N    F++++GL+   ++RLR TW+++PNK  K+++ +Q L D S NM   R++   ++ +PPVIP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +E +E D+  L  +S +CEP
Sbjct:  604 PDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVT-ATPEQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF-KLKSKT-----------------------------SCANLKKFEEVINQETFWVASEILRETNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALMFRTRKKKWRSLGSLSQGSANATVLDV-------------AQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLE-LEMDEESLQTLSLQCEP 1000

HSP 2 Score: 139.813 bits (351), Expect = 1.558e-32
Identity = 104/410 (25.37%), Postives = 184/410 (44.88%), Query Frame = 2

Query:  773 NEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREF-MSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            + +  +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV                   E L   +SFG      +E + K  + +  +DC  + I  +++ +I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD TFIEDF LTY  +L+S + V K ++E     S  R K T +V+ W+ NHF + E    + +F++     L RE    H   +   C+  + +R                              +MT+    RE  + F L    +K   +F+  + +CS      L  GD+++++N  + EN+   +A  IL  +    +TVK
Sbjct:   97 DPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYP------------DGKAEILCMGNSFGVSPTMDKEYM-KGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRR------------------------------LMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSCSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVK 462

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Mouse
Match: Rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:MGI Symbol;Acc:MGI:2659071])

HSP 1 Score: 176.792 bits (447), Expect = 7.727e-44
Identity = 126/459 (27.45%), Postives = 238/459 (51.85%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   + + K++ +S Y++ISK+T A EV+++++ E  ++ A+  ++ LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  +  F+ I  +E ID +  KL+ ++                             S  N ++F ++  +  ++V + +  ETN   KR KI+K  I++A  C+E  N    F++++GL+   ++RLR TW+++PNK  K+++ +Q L D S NM   R++   ++ +PPVIP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +E +E D+  L  +S +CEP
Sbjct:  606 PDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVT-ATPEQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF-KLKSKT-----------------------------SCANLKKFEEVINQETFWVASEILRETNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALMFRTRKKKWRSLGSLSQGSANATVLDV-------------AQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLE-LEMDEESLQTLSLQCEP 1002

HSP 2 Score: 139.813 bits (351), Expect = 1.847e-32
Identity = 104/410 (25.37%), Postives = 184/410 (44.88%), Query Frame = 2

Query:  773 NEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREF-MSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            + +  +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV                   E L   +SFG      +E + K  + +  +DC  + I  +++ +I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD TFIEDF LTY  +L+S + V K ++E     S  R K T +V+ W+ NHF + E    + +F++     L RE    H   +   C+  + +R                              +MT+    RE  + F L    +K   +F+  + +CS      L  GD+++++N  + EN+   +A  IL  +    +TVK
Sbjct:   99 DPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYP------------DGKAEILCMGNSFGVSPTMDKEYM-KGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRR------------------------------LMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSCSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVK 464

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Mouse
Match: Rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:MGI Symbol;Acc:MGI:2659071])

HSP 1 Score: 176.407 bits (446), Expect = 1.110e-43
Identity = 126/459 (27.45%), Postives = 238/459 (51.85%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   + + K++ +S Y++ISK+T A EV+++++ E  ++ A+  ++ LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  +  F+ I  +E ID +  KL+ ++                             S  N ++F ++  +  ++V + +  ETN   KR KI+K  I++A  C+E  N    F++++GL+   ++RLR TW+++PNK  K+++ +Q L D S NM   R++   ++ +PPVIP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +E +E D+  L  +S +CEP
Sbjct:  754 PDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVT-ATPEQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF-KLKSKT-----------------------------SCANLKKFEEVINQETFWVASEILRETNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALMFRTRKKKWRSLGSLSQGSANATVLDV-------------AQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLE-LEMDEESLQTLSLQCEP 1150

HSP 2 Score: 139.813 bits (351), Expect = 2.070e-32
Identity = 104/410 (25.37%), Postives = 184/410 (44.88%), Query Frame = 2

Query:  773 NEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREF-MSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            + +  +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV                   E L   +SFG      +E + K  + +  +DC  + I  +++ +I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD TFIEDF LTY  +L+S + V K ++E     S  R K T +V+ W+ NHF + E    + +F++     L RE    H   +   C+  + +R                              +MT+    RE  + F L    +K   +F+  + +CS      L  GD+++++N  + EN+   +A  IL  +    +TVK
Sbjct:  247 DPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYP------------DGKAEILCMGNSFGVSPTMDKEYM-KGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRR------------------------------LMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSCSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVK 612

HSP 3 Score: 63.1586 bits (152), Expect = 4.609e-9
Identity = 33/116 (28.45%), Postives = 58/116 (50.00%), Query Frame = 2

Query:  149 EDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSTIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFY 496
            ++P  R+ +++EI+  YL  +  L     +   L    V+Y+  + N  +    D    WY +L GSV I  +MFLP +SF  +   +     ECIVLE + +++  Y + N  ++
Sbjct:    2 KNPAERTPQDLEIVYSYLHGMEALSNLREHQLRLMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSFRRGCECIVLEPSEMIVVDYMDENEEYF 117

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Mouse
Match: Rapgef6 (Rap guanine nucleotide exchange factor (GEF) 6 [Source:MGI Symbol;Acc:MGI:2384761])

HSP 1 Score: 173.711 bits (439), Expect = 8.293e-43
Identity = 124/456 (27.19%), Postives = 232/456 (50.88%), Query Frame = 2

Query: 2570 YYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            +Y  P   I + K++ +S Y+IISK+T A EV+ +++ E  L+ AS++ + LCE+SV    +IKQ+ + +  S L   ++LN R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  ++ F+ I  +E ID +                            LD++ G +    + ++F  +  +  ++V + + SE+N   KR KI+K  I++A  C+E  N    F++++GL+   ++RLR TW+++P+K  K  + +Q L D S NM   R++   +S +PP+IP+  +V KD+T ++E + +KV  DG           L+NF+KLR++A   R    +             ++ N+ P      + F +  LS+     +   +    +    RRS+ +N KK+YE+     +VK ++  ++ ++ D+     MS + EP
Sbjct:  750 FYYIPDQVIRVFKADQQSCYIIISKDTTAKEVVCQAVQEFGLTGASDT-YSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELLKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLF--------------------------KLDSKTGNT----HLKQFEDIVNQETFWVASEILSESNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRGTWEKLPSKYEKHLQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHIIRM-------------TSANMDP-----AMMFRQRSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLD-IDTDEEKFQMMSLQWEP 1141

HSP 2 Score: 131.339 bits (329), Expect = 6.391e-30
Identity = 99/409 (24.21%), Postives = 184/409 (44.99%), Query Frame = 2

Query:  773 NEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            + +  +D +++ L+K  AD++  + E ++  +  +P F+  T S+R   C +   +VVE    V+++  +++  W   L GT+E+                  +E L   +SFG  +   ++Q     + +  +DC  + I  +++ +I +       ++ E  + VM+ E R     G+ KG +++KAT  +LI +L E H  VD T+IEDF LTY  +L + + V   ++E   ++   R K T IV+ W+ NHF + E    + +F++     L       H   +   C+  +  R V              ++   SR S                + F L    +K   +F+ ++ + S      L  GD+V+++N  + EN+T  +A  IL  +    LTVK
Sbjct:  244 DPLQGRDLVRECLEKEPADKTDDDVEQLLEFMHQLPAFANMTMSVRRELCSVMVFEVVEQAGAVILEDGQELDSWYVILNGTVEISHP------------DGKIENLFMGNSFGI-VPTLDKQHMHGAVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLETPLDVGIKLLEWF-KIDNLRDKVTRIVLLWVNNHFNDFEGDPAMTQFLEEFERNLEDTKMNGHLRLLNIACAAKAKWRQV--------------VLQKASRESP---------------LHFCLTGGSEKGFGVFVEEVESGSKAADAGLKRGDQVMEVNGQNFENITLAKALEILRNNTHLALTVK 609

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Mouse
Match: Rapgef6 (Rap guanine nucleotide exchange factor (GEF) 6 [Source:MGI Symbol;Acc:MGI:2384761])

HSP 1 Score: 172.17 bits (435), Expect = 1.639e-42
Identity = 123/452 (27.21%), Postives = 230/452 (50.88%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   I + K++ +S Y+IISK+T A EV+ +++ E  L+ AS++ + LCE+SV    +IKQ+ + +  S L   ++LN R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  ++ F+ I  +E ID +                            LD++ G +    + ++F  +  +  ++V + + SE+N   KR KI+K  I++A  C+E  N    F++++GL+   ++RLR TW+++P+K  K  + +Q L D S NM   R++   +S +PP+IP+  +V KD+T ++E + +KV  DG           L+NF+KLR++A   R    +             ++ N+ P      + F +  LS+     +   +    +    RRS+ +N KK+YE+     +VK ++  ++ ++ D+     MS + EP
Sbjct:  415 PDQVIRVFKADQQSCYIIISKDTTAKEVVCQAVQEFGLTGASDT-YSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELLKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLF--------------------------KLDSKTGNT----HLKQFEDIVNQETFWVASEILSESNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRGTWEKLPSKYEKHLQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHIIRM-------------TSANMDP-----AMMFRQRSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLD-IDTDEEKFQMMSLQWEP 802

HSP 2 Score: 90.5077 bits (223), Expect = 1.690e-17
Identity = 70/272 (25.74%), Postives = 121/272 (44.49%), Query Frame = 2

Query: 1184 LMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
             + I  +++ +I +       ++ E  + VM+ E R     G+ KG +++KAT  +LI +L E H  VD T+IEDF LTY  +L + + V   ++E   ++   R K T IV+ W+ NHF + E    + +F++     L       H   +   C+  +  R V              ++   SR S                + F L    +K   +F+ ++ + S      L  GD+V+++N  + EN+T  +A  IL  +    LTVK
Sbjct:   34 FVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLETPLDVGIKLLEWF-KIDNLRDKVTRIVLLWVNNHFNDFEGDPAMTQFLEEFERNLEDTKMNGHLRLLNIACAAKAKWRQV--------------VLQKASRESP---------------LHFCLTGGSEKGFGVFVEEVESGSKAADAGLKRGDQVMEVNGQNFENITLAKALEILRNNTHLALTVK 275

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. UniProt/SwissProt
Match: sp|Q9Y4G8|RPGF2_HUMAN (Rap guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=RAPGEF2 PE=1 SV=1)

HSP 1 Score: 177.563 bits (449), Expect = 3.256e-43
Identity = 126/459 (27.45%), Postives = 237/459 (51.63%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   + + K++ +S Y++ISK+T A EV+++++ E  ++ A+  ++ LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  +  F+ I  +E ID +  KLR ++                             S  N + F ++  +  ++V + +  ETN   KR KI+K  I++A  C+E  N    F++++GL+   ++RLR TW+++PNK  K+++ +Q L D S NM   R++   ++ +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +E +E D+  L  +S +CEP
Sbjct:  606 PDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVT-ATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF-KLRSKT-----------------------------SCANLKRFEEVINQETFWVASEILRETNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDV-------------AQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLE-LEMDEESLQTLSLQCEP 1002

HSP 2 Score: 134.806 bits (338), Expect = 3.848e-30
Identity = 103/410 (25.12%), Postives = 183/410 (44.63%), Query Frame = 2

Query:  773 NEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREF-MSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            + +  +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV                   E L   +SFG      +E + K  + +  +DC  + I  +++ +I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD TFIEDF LTY  +L+S + V K ++E     S  R K T +V+ W+ NHF + E    + +F++     L RE    H   +   C+  + +R                              +MT+    RE  + F L    +K   +F+  + + S      L  GD+++++N  + EN+   +A  IL  +    +TVK
Sbjct:   99 DPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYP------------DGKAEILCMGNSFGVSPTMDKEYM-KGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRR------------------------------LMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVK 464

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. UniProt/SwissProt
Match: sp|Q8CHG7|RPGF2_MOUSE (Rap guanine nucleotide exchange factor 2 OS=Mus musculus OX=10090 GN=Rapgef2 PE=1 SV=2)

HSP 1 Score: 176.792 bits (447), Expect = 5.405e-43
Identity = 126/459 (27.45%), Postives = 238/459 (51.85%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   + + K++ +S Y++ISK+T A EV+++++ E  ++ A+  ++ LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  +  F+ I  +E ID +  KL+ ++                             S  N ++F ++  +  ++V + +  ETN   KR KI+K  I++A  C+E  N    F++++GL+   ++RLR TW+++PNK  K+++ +Q L D S NM   R++   ++ +PPVIP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +E +E D+  L  +S +CEP
Sbjct:  606 PDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVT-ATPEQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF-KLKSKT-----------------------------SCANLKKFEEVINQETFWVASEILRETNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALMFRTRKKKWRSLGSLSQGSANATVLDV-------------AQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLE-LEMDEESLQTLSLQCEP 1002

HSP 2 Score: 139.813 bits (351), Expect = 1.292e-31
Identity = 104/410 (25.37%), Postives = 184/410 (44.88%), Query Frame = 2

Query:  773 NEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREF-MSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            + +  +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV                   E L   +SFG      +E + K  + +  +DC  + I  +++ +I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD TFIEDF LTY  +L+S + V K ++E     S  R K T +V+ W+ NHF + E    + +F++     L RE    H   +   C+  + +R                              +MT+    RE  + F L    +K   +F+  + +CS      L  GD+++++N  + EN+   +A  IL  +    +TVK
Sbjct:   99 DPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYP------------DGKAEILCMGNSFGVSPTMDKEYM-KGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRR------------------------------LMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSCSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVK 464

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. UniProt/SwissProt
Match: sp|F1M386|RPGF2_RAT (Rap guanine nucleotide exchange factor 2 OS=Rattus norvegicus OX=10116 GN=Rapgef2 PE=1 SV=2)

HSP 1 Score: 176.792 bits (447), Expect = 5.736e-43
Identity = 126/459 (27.45%), Postives = 238/459 (51.85%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   + + K++ +S Y++ISK+T A EV+++++ E  ++ A+  ++ LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  +  F+ I  +E ID +  KL+ ++                             S  N ++F ++  +  ++V + +  ETN   KR KI+K  I++A  C+E  N    F++++GL+   ++RLR TW+++PNK  K+++ +Q L D S NM   R++   ++ +PPVIP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +E +E D+  L  +S +CEP
Sbjct:  606 PDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVT-ATPEQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF-KLKSKT-----------------------------SCANLKKFEEVINQETFWVASEILRETNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALMFRTRKKKWRSLGSLSQGSANATVLDV-------------AQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLE-LEMDEESLQTLSLQCEP 1002

HSP 2 Score: 137.117 bits (344), Expect = 8.242e-31
Identity = 102/404 (25.25%), Postives = 186/404 (46.04%), Query Frame = 2

Query:  773 NEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCSDLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            + +  +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV                   E L   +SFG      +E + K  + +  +DC  + I  +++ +I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD TFIEDF LTY  +L+S + V K ++E     S  R K T +V+ W+ NHF + E    + +F++     L RE    H   +   C+  + +R++T+    + +   P I+  GS                     F +F     ++++  S     + L  GD+++++N  + EN+   +A  IL  +    +TVK
Sbjct:   99 DPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYP------------DGKAEILCMGNSFGVSPTMDKEYM-KGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRSMTLTKPSR-EAPLPFILLGGSE------------------KGFGIF-----VDSVDSSSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVK 464

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. UniProt/SwissProt
Match: sp|F1PBJ0|RPGF2_CANLF (Rap guanine nucleotide exchange factor 2 OS=Canis lupus familiaris OX=9615 GN=RAPGEF2 PE=1 SV=2)

HSP 1 Score: 176.022 bits (445), Expect = 9.478e-43
Identity = 126/459 (27.45%), Postives = 237/459 (51.63%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKS--CKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   + + K++ +S Y++ISK+T A EV+++++ E  ++ A+  ++ LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  +  F+ I  +E ID +  KL+ ++                             S  N ++F ++  +  ++V + +  ETN   KR KI+K  I++A  C+E  N    F++++GL+   ++RLR TW+++PNK  K+++ +Q L D S NM   R++  S   +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +E +E D+  L  +S +CEP
Sbjct:  606 PDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVT-ATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF-KLKSKT-----------------------------SCANLKKFEEVINQETFWVASEILRETNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDV-------------AQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLE-LEMDEESLQTLSLQCEP 1002

HSP 2 Score: 134.806 bits (338), Expect = 3.656e-30
Identity = 103/410 (25.12%), Postives = 183/410 (44.63%), Query Frame = 2

Query:  773 NEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREF-MSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            + +  +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV                   E L   +SFG      +E + K  + +  +DC  + I  +++ +I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD TFIEDF LTY  +L+S + V K ++E     S  R K T +V+ W+ NHF + E    + +F++     L RE    H   +   C+  + +R                              +MT+    RE  + F L    +K   +F+  + + S      L  GD+++++N  + EN+   +A  IL  +    +TVK
Sbjct:   99 DPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYP------------DGKAEILCMGNSFGVSPTMDKEYM-KGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRR------------------------------LMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVK 464

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BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. UniProt/SwissProt
Match: sp|F1MSG6|RPGF2_BOVIN (Rap guanine nucleotide exchange factor 2 OS=Bos taurus OX=9913 GN=RAPGEF2 PE=1 SV=2)

HSP 1 Score: 175.637 bits (444), Expect = 1.211e-42
Identity = 127/459 (27.67%), Postives = 236/459 (51.42%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKS--CKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   + + K++ +S Y++ISK+T A EV+V+++ E  ++ A+  ++ LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  +  F+ I  +E ID +  KL+ ++                             S  N + F ++  +  ++V + +  ETN   KR KI+K  I++A  C+E  N    F++++GL+   ++RLR TW+++PNK  K+++ +Q L D S NM   R++  S   +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +E +E D+  L  +S +CEP
Sbjct:  606 PDQVLRVFKADQQSRYIMISKDTTAKEVVVQAIREFAVT-ATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF-KLKSKT-----------------------------SCANLKTFEEVINQETFWVASEILRETNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDV-------------AQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLE-LEMDEESLQTLSLQCEP 1002

HSP 2 Score: 135.576 bits (340), Expect = 2.226e-30
Identity = 103/410 (25.12%), Postives = 182/410 (44.39%), Query Frame = 2

Query:  773 NEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREF-MSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            + +  +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV                   E L   +SFG      +E + K  + +  +DC  + I  +++ +I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD TFIEDF LTY  +L S + V K ++E     S  R K T +V+ W+ NHF + E    + +F++     L RE    H   +   C+  + +R                              +MT+    RE  + F L    +K   +F+  + + S      L  GD+++++N  + EN+   +A  IL  +    +TVK
Sbjct:   99 DPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYP------------DGKAEILCMGNSFGVSPTMDKEYM-KGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLCSPMEVGKKLLEWFNDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRR------------------------------LMTLTKPAREAPLPFILLGGSEKGFGIFVDSVDSASKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVK 464

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BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. TrEMBL
Match: A0A061QLK9 (Putative rap guanine nucleotide exchange factor OS=Cupiennius salei OX=6928 GN=CSH_0420 PE=2 SV=1)

HSP 1 Score: 285.419 bits (729), Expect = 3.745e-74
Identity = 271/1092 (24.82%), Postives = 487/1092 (44.60%), Query Frame = 2

Query:  767 TFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERRCSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQI--PRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSS-------LTH------SAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNE---NLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKS--CKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSAC-INTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNV 3964
            + N ++ +D +++ L+K   +R+  + EV++  +Q++P F+  T ++R A C +    VVE   T+++   E++  W   + G +EV +                +E L   DSFG     +E+   +  + +  +DC  + I   ++ +I  Q      +  E+ + V++ E R    GS +G ++++ TV +L+ +L E++  +D +++EDF LTY  ++ + ++V + ++     P +   R K T +V+ W+ NHF + E   ++M+F++     L +EN +     +   C+T +  R VT+  + +D                             E + F++    ++   +F+S++   S      L  GD+++++N  S E+++   A  +L  +    +TV+ +  GF        L     SP  RS        L H      S  LD+ D     G S  PL     G+ P             + Q+  S  +K +      +     E K+   +    A       ++  P    +E   N SD  + S + S S   +    +R  +P            S PDL           S    E V+KVY  D T             +L++ KET A EV++ SL E  ++  S S + L E+SV  G ++KQ+ + +   NL   + LN+R+++K    +  L+ +    E+  E  V F  L   E+ATQ+ +E ++ F++I  +E ID +      E S+    P+                           +F +L    M++VV  VC+E +   +R +I+K+ I++AR CK   N    F++++GL    +SRLR TW+++P+K  K++  +Q L+D S NM   R+L  S   +PP+IP   +V KDLT I+  + T V++             L+NF+KLR++A   R   N+   CS     A     N+L E  GA        ++ ++   ++   +T +    R++SA   N KK++E      RVK ++  ++ +  D+  L  MS +CEP    TG  P V
Sbjct:  183 SLNSLTVRDTVRECLEKDPCERTEDDIEVLLEFMQHLPAFANMTLTIRRALCAVMVFAVVEKAGTIVMNDGEELDSWSVIVNGHVEVEQQ------------DGRIEELHLGDSFGIT-PTTEKMYHQGVMRTKVDDCQFVCIAQSDYYRILHQGEENTRKHEEDGEVVLVTEHRVLDGGSRRGHIVIRGTVERLMAHLVEDNA-LDPSYVEDFLLTYRTFVKNPLVVTENLLSWFSDPHL---RDKVTRVVLLWVNNHFTDFETDPDMMEFLEKFEACLEKENMQSQLRLLNIACATKARNRTVTLARSTRD-----------------------------EVLHFHILGGYERGFGVFVSKVDKSSKAEEVGLKRGDQILEVNGQSFEHMSHARALEVLRGTTHLCITVRSNLLGFK-----EMLNTPENSPRPRSRKASEIARLQHDPQARLSTHLDWGDVGFPIGVSGFPL-----GVVP-------------LFQTPHSPPIKAVRSNSNNSGDLKKEDKKGFMTLGHRAKLKKALVKMIIPKTLNHESQLNSSDDSLYS-IHSGSSGGSGGVGVRTASPHRTAGGTLYHSHSNPDLSSLTALTEQPLSLDYPEHVLKVYKSDQTFK-----------FLLVHKETTAREVVMLSLREFGITDPS-SNYSLREVSVGDGGVLKQRRLPDQLQNLAERIGLNSRYYLKNNASTEPLVPDELATELLRESQVHFLQLNSVEVATQLTLEDFSTFRQIEPTEYIDDLF-----EVSSKYGTPQ-------------------------LSKFAELVNHEMFWVVTEVCAE-HQLIRRMRIIKQFIKVARQCKICKNFNSMFAILSGLGHGAVSRLRTTWEKLPSKYQKIFSDLQDLMDPSRNMCKYRNLLNSEHTQPPIIPFYPVVKKDLTFIHLGNDTFVDN-------------LVNFEKLRMIAKEVRQLMNM---CS-----APYDLFNML-EIGGAHPT---AAMASLNSFVTTTNAATVK---KRKKSAAQPNPKKMFEEAQMVRRVKTYLSNLKVIS-DEEKLRTMSLECEPN---TGPVPMV 1129

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BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. TrEMBL
Match: A0A087T7I6 (Rap guanine nucleotide exchange factor 2 (Fragment) OS=Stegodyphus mimosarum OX=407821 GN=X975_20148 PE=4 SV=1)

HSP 1 Score: 281.182 bits (718), Expect = 7.880e-73
Identity = 263/1078 (24.40%), Postives = 481/1078 (44.62%), Query Frame = 2

Query:  767 TFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERRCSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSS-------LTH------SAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNE---NLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKS--CKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            + N ++ +D +++ L+K   +R+  + EV++  +Q++P F+  T ++R A C +    VVE   TV++   E++  W   + G +EV        +  D  +    E L   DSFG     +E+   +  + +  +DC  + I   ++ +I  Q      +  E+ + V++ E R    GS +G ++++ TV +L+ +L E++  +D +++EDF LTY  ++++ + + + ++      +  R K T +V+ W+ NHF + E   E+M+F++     L +E  +     +   C+T +  R VT+  + +D                             E + F++    ++   +F+S++   S      L  GD+++++N  S E+++   A  +L  +    +TV+ +  GF        L     SP  RS        L H      S  L++ D     G S  PL     G+ P             + Q+ +S  +K +      +     E K+   +    A       ++  P    +E   N SD  + S + S S   +    IR  +P            S PDL      +    +    E V+KVY  D T             +L++ KET A EV++ SL E  ++  S S + L E+SV  G ++KQ+ + +   NL   + LN+R+++K    +  L+ +    E+  E  V F  L   E+ATQ+ +E ++ F++I  +E ID +      E S+    P+                           +F +L  + M++VV  VC+E +   +R +I+K+ I++AR CK   N    F+++ GL    +SRLR+TW+++P K  K++  +Q L+D S NM   R+L  S   +PP+IP   +V KDLT I+  + T V++             L+NF+KLR++A   R   N+   CS     A     N+L        A +  + S +    ++   +T +    ++ +A  N KK++E      RVK ++  ++ +  D+  L  MS +CEP
Sbjct:  185 SLNSLTVRDTVRECLEKDPCERTEDDIEVLLEFMQHLPAFANMTLTIRRALCAVMVFAVVEKAGTVVMNDGEELDSWSVIVNGHVEV--------EYPDGRV----EELHLGDSFGIT-PTTEKMYHQGVMRTKVDDCQFVCIAQSDYYRILHQGEENTRKHEEDGEVVLVTEHRVLDGGSRRGHIVIRGTVERLMAHLVEDNA-LDPSYVEDFLLTYRTFISNPLSITENLLRWFADAN-LRDKVTRVVLLWVNNHFTDFETDPEMMEFLEKFEAGLEKEKMQSQLRLLNIACATKARNRTVTLARSTRD-----------------------------EVLHFHILGGYERGFGVFVSKVDKGSKAEEVGLKRGDQILEVNGQSFEHMSHARALEVLRGTTHLCITVRSNLLGFK-----EMLNTPENSPRPRSRKASEIARLQHDPQARLSTHLEWGDIGFPLGVSGYPL-----GVVP-------------IFQTPSSPPIKAVRSNSNNSGDLKKEDKKGFMTLGHRAKLKKALVKMIIPKTLNHESQLNSSDDSLYS-IHSGSSGGSGGLGIRTASPHRTGGGTLYHSHSNPDLSSVTALSEQPLTLDYPEHVLKVYKSDQTFK-----------FLLVHKETTAREVVMLSLREFGITDPS-SNYSLREVSVGDGGVVKQRRLPDQLQNLAERIGLNSRYYLKNNASTEPLVPDELATELLRESQVHFLQLNSVEVATQLTLEDFSTFRQIEPTEYIDDLF-----EVSSKYGTPQ-------------------------LSKFAELVNREMFWVVTEVCAE-HQLIRRMRIVKQFIKVARQCKVCKNFNSMFAILCGLGHGAVSRLRSTWEKLPTKYQKIFSDLQDLMDPSRNMCKYRNLLNSEHTQPPIIPFYPVVKKDLTFIHLGNDTFVDN-------------LVNFEKLRMIAKEVRQLMNM---CS-----APYDLFNMLEIGGAHPTAAMASLNSFV----TTTNAATVKK--RKKSTAQPNPKKMFEEAQMVRRVKTYLSNLKVIS-DEEKLRTMSLECEP 1123

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BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. TrEMBL
Match: A0A1U8DQ84 (rap guanine nucleotide exchange factor 6 isoform X8 OS=Alligator sinensis OX=38654 GN=RAPGEF6 PE=4 SV=1)

HSP 1 Score: 280.026 bits (715), Expect = 2.917e-72
Identity = 269/1089 (24.70%), Postives = 487/1089 (44.72%), Query Frame = 2

Query:  767 TFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSP-VDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKI-RSRCGSQPDLRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKES---SKGLSTSQNHLN---------RRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVS 3967
            T + +  +D +++ L+K  AD++  + E ++  +  +P F+  T S+R   C +   +VVE    ++++  +++  W   L GT+E+                   E L   +SFG      E+Q     + +  +DC  + I  +++ +I +       ++ E  + VM+ E R     G+ KG +++KAT  +LI +L E H  VD T+IEDF LTY  +L+S + V   ++E   +V   R K T +V+ W+ NHF + E    + +F++     L     + H   +   C+  +  R +T+    +D                               + F+L    +K   +F+  +   S      L  GD+++++N  + EN+T  +A  IL  +    +TVK +   F    L    + KN  P + + +   +     PD P +           +  I P+ +G  KKM  N V  S   + +KK++ +                           RF +  P L      SD  ++ +       + SI   R    ++ +  I  +   S PDL +     +      S  S +  YY  P   I + K++ +S Y+IISK+T A EV+  ++ E NL+ AS + + LCE+SV    +IKQ+ + +  S L   ++LN R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  +  F+ I  +E ID +                            LD++ G +    + ++F  +  +  ++V   +  E N   KR KI+K  I++A  C+E  N    F++++GL+   ++RLR TW+++P+K  K +R +Q L D S NM   R++   +S +PP+IP+  +V KD+T ++E + +KV  DG           L+NF+KLR++   A+  + ++   S N   A+   +         Q   +  + S+     +   S+G ST+ N L+          RRS+ +N KK+YE+     +VK ++  +  +E D+     MS +CEP    + LT N+S
Sbjct:  244 TSDPLLGRDVVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEISYP------------DGKTENLCMGNSFGI-TPSLEKQYMNGVVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVKEHRELDRSGTRKGHIVIKATPERLITHLIEEHSIVDPTYIEDFLLTYRTFLSSPLEVGDKLLEWF-KVDSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFEKNLENTKMKGHLRLLNIACAAKAKWRQITLQKASRDSP-----------------------------LYFSLLGGSEKGFGIFVETVETGSKAAEVGLKRGDQIMEVNGQNFENITFVKALEILRNNTHLSITVKTNIFVF-KELLSRIGQEKNGVPHIPKIAEKKNNRYSIPDMPGD-----------MEQIFPREKGN-KKMKANTV--SGGRNRIKKILDKT--------------------------RFSILPPKL-----FSDGSVSQS------QDDSIVGTRQCRHSLAIMPIPGTLSSSSPDLLQ----PTTSILDFSNPSAVGFYYI-PDQVIRVFKADQQSCYIIISKDTTAKEVVSHAVHEFNLTGASET-YSLCEVSVSPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTIEVATQLSMRDFELFRNIEPTEYIDDL--------------------------FKLDSKTGNA----HLKQFEDVINQETFWVATEILLEPNQL-KRMKIIKHFIKIALHCRECKNFNSMFAVISGLNLASVARLRGTWEKLPSKYEKHFRDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDITFLHEGNDSKV--DG-----------LVNFEKLRMI---AKEIRQVIRMTSANMDPAVMFRQRKKRWRSLGQTMHVSGLDSRCHQHRARSLSQG-STNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSNL-NVETDEEKFQIMSLQCEP--AYSTLTKNLS 1180

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BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. TrEMBL
Match: A0A553MNC9 (Uncharacterized protein OS=Danionella translucida OX=623744 GN=DNTS_031226 PE=4 SV=1)

HSP 1 Score: 278.87 bits (712), Expect = 8.746e-72
Identity = 259/1057 (24.50%), Postives = 472/1057 (44.65%), Query Frame = 2

Query:  788 QDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV         + D +     E L   +SFG      E++  K  + +  +DC  + I  +++  I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L+S ++V K ++E     S  R K T +V+ W+ NHF + E  S +  F++     L RE    H   +   C+  +  R VT+    ++                               ++F+L    ++   +FI  + + S      L  GD+++++N  + EN+   +AN IL  +    +TVK +        L+  L R +Q             LD  +       ++ P  PK+G I    +   +  +P+          L+K  K+ KAN+     K +K   K+ ++   P  +         ++++  LK +  +        ++S+   +      R +     +QPD+                + V++V+           K++ +S Y++I K+T A EV+ +++ E  L+ A  + + LCE+SV    +IKQ+ + E  S L   ++L+ R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  +  F  I  +E I+     L K  S     P                      S+  F+E +    +  ++V   V  E N   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K++  +Q L D S NM   R+L   ++ +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    ++N   A+                F    LS+     +   ++ +  H  R RRS+ +N KK+YE+     RVK ++  +  +E ++  L  +S +CEP
Sbjct:   72 RDIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEV--------THPDGHT----EILCMGNSFGVS-PTMEKEFMKGVMKTKVDDCQFVCIAQQDYCCILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFHDPS-LRDKVTRVVLLWVNNHFNDFEGDSAMTHFLEEFEFNLEREKMCGHLRLLNIACAAKAKLRVVTLTKPSREAP-----------------------------LAFSLLGGSERGFRIFIDSVEDGSKAAEVGLKRGDQILEVNGQNFENVPLSKANEILKNNTHLSITVKTN--------LLELLARPDQD----QDPEQDEELDRKNG------ASHPHIPKIGDI----KKASRFSIPDLAVDVEQVMELEKASKKAKANTVGGRNKLKKIFDKTLTSILPPKPYNDVGVGQTQDDSIVGLKQSKQIPPALPVSGNLSSSNPDLLQSHHRILD--FNNQPDM---------------SDQVLRVF-----------KADQQSRYIMIGKDTTAKEVVAQAIREFALTAAPEA-YSLCEVSVTPEGVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIE----DLFKLKSRFTGPP----------------------SLKLFEEAIN---RETFWVATEVVREPNQL-KRMKIVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNLLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---AAVNMDPALM---------------FRTRSLSQGSANAAVLDVTQTGGHKKRVRRSSFLNAKKLYEDAQMARRVKQYLSNL-TLETNEESLQTLSTQCEP 972

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. TrEMBL
Match: A0A3B4ENE6 (Rap guanine nucleotide exchange factor (GEF) 2 OS=Pygocentrus nattereri OX=42514 PE=4 SV=1)

HSP 1 Score: 277.715 bits (709), Expect = 9.060e-72
Identity = 257/1063 (24.18%), Postives = 471/1063 (44.31%), Query Frame = 2

Query:  788 QDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV                   E L   +SFG      E++  K  + +  +DC  + I  +++  I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L+S ++V K ++E     S  R K T +V+ W+ NHF + E   E+  F++     L RE    H   +   C+  +  R VT+    ++                               ++F L    +K   +FI  +   S      L  GD+++++N  + EN+   +AN IL  +    +TVK +  G     +  +L RKN +                           P  PK+G I    +   +  +P+          L+K  K+ KAN+     K +K   K+ ++   P  +       + ++++  LK +  +        ++S+   +      R +     +QPD+                + V++V+           K++ +S Y++I K+T A EV+ +++ E  L+ A  + + LCE+SV    +IKQ+ + E  S L   ++L+ R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  +  F  I  +E ID +  KLR                         +R     S+  F+E +    +  ++V   V  E N   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K++  +Q L D S NM   R++   ++ +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    ++N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +  +E ++  L  +S +CEP
Sbjct:  101 RDIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYP------------EGRTEILCMGNSFGVS-PTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTTERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFHDPS-LRDKVTRVVLLWVNNHFNDFEGDPEMTHFLEEFENNLEREKMCGHLRLLNIACAAKAKLRVVTLTKPSREAP-----------------------------LAFTLLGGSEKGFRIFIDHVEPGSKAAEAGLKRGDQILEVNGQNFENVQLSKANEILRNNTHLSITVKTNLLGKLQ--IQTFLDRKNGA---------------------------PHIPKIGDI----KKASRYSIPDLAVDVEQVMGLEKASKKAKANTVGGRNKLKKIFDKTLTSILPPKPYNDVGVGQSQDDSIVGLKQSKQIPPALPVSGNLSSSNPDLLQSHHRILD--FNNQPDM---------------SDQVLRVF-----------KADQQSRYIMIGKDTTAKEVVAQAIREFALTAAPEA-YSLCEVSVTPEGVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLF-KLR-------------------------SRSAGPSSLKLFEEAIN---RETFWVATEVVREPNQL-KRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---AAVNMDPALMFRTRKKKWRSLGSLSQGSANAAVLDV-------------TQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNL-TLETNEESLQTLSIQCEP 998

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BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Cavefish
Match: rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6959])

HSP 1 Score: 276.944 bits (707), Expect = 7.174e-75
Identity = 256/1063 (24.08%), Postives = 468/1063 (44.03%), Query Frame = 2

Query:  788 QDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV                   E L   +SFG      E++  K  + +  +DC  + I  +++  I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L+S ++V K ++E     S  R K T +V+ W+ NHF + E   E+  F++     L RE    H   +   C+  +  R VT+    ++                               ++F L    +K   +FI  +   S      L  GD+++++N  + EN+   +AN IL  +    +TVK            N L +KN +                           P  PK+G I    +   +  +P+          L+K  K+ KAN+     K +K   K+ ++   P  +       + ++++  LK +  +        ++S+   +      R +     +QPD+                + V++V+           K++ +S Y++I K+T A EV+ +++ E  L+ A  + + LCE+SV    +IKQ+ + E  S L   ++L+ R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  +  F  I  +E ID +  KLR  +S                            S+  F+E +    +  ++V   V  E N   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K++  +Q L D S NM   R++   ++ +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    ++N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +  +E ++  L  +S +CEP
Sbjct:  111 RDIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYP------------EGRTEILCMGNSFGVS-PTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTTERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWF-HDSSLRDKVTRVVLLWVNNHFNDFEGDPEMTHFLEEFENNLEREKMCGHLRLLNIACAAKAKLRVVTLTKPSREAP-----------------------------LAFTLLGGSEKGFRIFIDHVEPGSKAAEAGLKRGDQILEVNGQNFENVQLSKANEILRNNTHLSITVK-----------TNLLGKKNGA---------------------------PHIPKIGDI----KKASRYSIPDLAVDVEQVMGLEKASKKAKANTVGGRNKLKKIFDKTLTSILPPKPYNDVGVGQSQDDSIVGLKQSKQIPPALPVSGNLSSSNPDLLQSHHRILD--FNNQPDM---------------SDQVLRVF-----------KADQQSRYIMIGKDTTAKEVVAQAIREFALTAAPEA-YSLCEVSVTPEGVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLF-KLRSRASG-------------------------PSSLKLFEEAIN---RETFWVATEVVREPNQL-KRMKIVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---AAVNMDPALMFRTRKKKWRSLGSLSQGSANAAVLDV-------------TQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNL-TLETNEESLQTLSIQCEP 999

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Cavefish
Match: rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6959])

HSP 1 Score: 258.07 bits (658), Expect = 5.075e-69
Identity = 259/1070 (24.21%), Postives = 464/1070 (43.36%), Query Frame = 2

Query:  788 QDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKXXXX------XXXXXXXXXXXXVIKVYYKDPTDS-ISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV                   E L   +SFG      E++  K  + +  +DC  + I  +++  I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L+S ++V K ++E     S  R K T +V+ W+ NHF + E   E+  F++     L RE    H   +   C+  +  R VT+    ++                               ++F L    +K   +FI  +   S      L  GD+++++N  + EN+   +AN IL  +    +TVK +        LV   K     P       H   LD  +          P  PK+G I    +   +  +P+          L+K  K+ KAN+     K +K   K+ ++   P  +       + ++++  LK +  +        ++S+                  S PDL +S               ++  + V++V+  D     I IGK          +KE  A     +++ E  L+ A  + + LCE+SV    +IKQ+ + E  S L   ++L+ R+++K    +  L  + D +E+  E  ++   L   E+ATQ+ +  +  F  I  +E ID +  KLR  +S                            S+  F+E +    +  ++V   V  E N   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K++  +Q L D S NM   R++   ++ +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    ++N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +  +E ++  L  +S +CEP
Sbjct:  104 RDIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYP------------EGRTEILCMGNSFGVS-PTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTTERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWF-HDSSLRDKVTRVVLLWVNNHFNDFEGDPEMTHFLEEFENNLEREKMCGHLRLLNIACAAKAKLRVVTLTKPSREAP-----------------------------LAFTLLGGSEKGFRIFIDHVEPGSKAAEAGLKRGDQILEVNGQNFENVQLSKANEILRNNTHLSITVKTN-------LLV--FKELLARPEHDQEHDHEEELDRKNG--------APHIPKIGDI----KKASRYSIPDLAVDVEQVMGLEKASKKAKANTVGGRNKLKKIFDKTLTSILPPKPYNDVGVGQSQDDSIVGLKQSKQIPPALPVSGNLSS------------------SNPDLLQSHHRILDFNNQPEPVPTNMSDQVLRVFKADQQSRYIMIGKDTT-------AKEVVA-----QAIREFALTAAPEA-YSLCEVSVTPEGVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLF-KLRSRASG-------------------------PSSLKLFEEAIN---RETFWVATEVVREPNQL-KRMKIVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---AAVNMDPALMFRTRKKKWRSLGSLSQGSANAAVLDV-------------TQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNL-TLETNEESLQTLSIQCEP 1018

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Cavefish
Match: rapgef6 (Rap guanine nucleotide exchange factor (GEF) 6 [Source:ZFIN;Acc:ZDB-GENE-030131-6972])

HSP 1 Score: 169.859 bits (429), Expect = 1.426e-42
Identity = 126/462 (27.27%), Postives = 227/462 (49.13%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPR-SEITGLT 3955
            P   I + K++ +S Y+IISK+T A +V+   + E  L  A  + + LCE+S+    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +E+  E  ++   L   E+A Q+ +  +  F+ I  +E +D +                            LD   G+   +  F+E +    +  ++V   +  E N+  KR K +K  I++A  C+E  N    F++++GL+   ++RLR TW+++P+K  K++R +Q + D S NM   R++   +S +PP+IP+  +V KDLT ++E + + V  DG           L+NF+KLR++A   R    +             ++ N+ P      + F +  LS+     +S  L     H  R RRS+ +N KK+YE+     +VK ++  + Q+E D+     MS +CEP  S ++G T
Sbjct:   31 PDQVIRVFKADQQSCYIIISKDTTAKDVVSHVVNEFGLIAAPET-YSLCEVSISPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVAAQLSMRDFGIFRNIESTEYVDDLF--------------------------KLDPGGGEGGHLKQFEELIN---QETFWVATEILCEANAF-KRMKTVKHFIKIALHCRECKNFNSMFAIISGLNLSPVARLRGTWEKLPSKYEKLFRDLQDIFDPSRNMAKYRNILSSQSVQPPIIPLFPVVKKDLTFLHEGNDSNV--DG-----------LVNFEKLRMIAKEIRHVVRM-------------TSANMDPA-----LMFRQRSLSQG--STNSNLLDVQGGHKKRVRRSSLLNAKKLYEDAQMARKVKQYLANL-QVETDEEKFQIMSLQCEPAYSTLSGST 427

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Cavefish
Match: si:dkey-253i9.4 (si:dkey-253i9.4 [Source:ZFIN;Acc:ZDB-GENE-090313-280])

HSP 1 Score: 140.584 bits (353), Expect = 5.585e-33
Identity = 102/362 (28.18%), Postives = 179/362 (49.45%), Query Frame = 2

Query: 2570 YYKDPTDSI-SIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSIN 3646
            Y   P D +  + K++ +S YL+I+++T A EV   ++ E  L     + + LCE+SV    +IKQ+ + +  S L   ++L  R+++K    +  L  +V+ +E+  E  V    L   E+A Q+    Y  F  +   E  D++T          K +P   P                     N + F  L  +  ++V   +  E N   KR KI+K  I++A  C++  N    F++++GL+   +SRLR TW+R+P K  K+  ++Q++ D S NM   R+L    + +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++   AR  ++++   S+N
Sbjct:  732 YSTQPPDQVLRVFKADQQSRYLLINRDTTAREVANLAIKEFGLGGGPEA-YSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLCARYYLKSNMETETLCSDVEAQELQRESQVCLLSLSCTEIANQLSARNYLLFASV---EPTDYITDLF-------KLRPHERPA--------------------NLRNFEDLINQETFWVATEIVREANQV-KRMKIIKHFIKVALHCRDCKNFNSMFAIISGLNLAPVSRLRATWERLPGKYEKLLSELQEVFDPSRNMAKYRNLLNKHNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMI---AREIRHVVRMASVN 1045

HSP 2 Score: 134.806 bits (338), Expect = 4.062e-31
Identity = 101/407 (24.82%), Postives = 187/407 (45.95%), Query Frame = 2

Query:  788 QDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQI--PRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYH-TCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            +D ++D L+K   DR+  + E ++  +Q +P F+  + S+R   C +    VVE   T+++   E++  W   L G +EV                   ET+    SFG      E+++    + +  +DC  + I  +++  I +Q      ++ E  + VM+ E R     G+ KG ++VK T  +LI++L E+H  VD T+IEDF LTY  +++S ++V + +++    P +   R K T +V+ W+ NHF + E   ++  F++     L R+ +     ++ +  C+  +  R V+I      +GSR +                         + F L    ++   LFIS +   S      L  GD+++++N  + EN+   +A  IL  +    +TVK
Sbjct:  241 RDIVRDCLEKDPMDRTDDDIEQLLEFVQQLPAFASLSVSVRRELCAVMVFAVVERAGTIVLNHGEELDSWSVILNGAVEVMYP------------DGQCETVGMGGSFGVS-PSMEKELMVGVMRTKVDDCQFVCIAQQDYCCILNQVEQNTQRVEEEGEIVMVKEHRELDRTGTRKGHIVVKGTTERLIQHLVEDHSVVDPTYIEDFLLTYRTFVSSPLIVGQRLLDWFNDPGL---RDKVTRVVLLWVNNHFSDFEGDPDMTNFLEEFQNYLERDQKMTGQLRLLNIACAAKAKPRVVSIT-----RGSREMP------------------------LPFTLIGGAERGTRLFISSVEMGSKAEEAGLKRGDQILEVNGQTFENVQLSKATEILKNNLHLSMTVK 602

HSP 3 Score: 55.0694 bits (131), Expect = 7.915e-7
Identity = 29/99 (29.29%), Postives = 48/99 (48.48%), Query Frame = 2

Query:  176 NIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSTIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPY 472
            +++I+  YL  +  L     +   L    V+Y+  + N  +    D    WY +L GSV I  +MFLP +SF  +   +     ECIVLE + +++  Y
Sbjct:   21 DLQIVYSYLHGMEALSNLREHQLRLMCETVRYEQHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEASEMIVVDY 119

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BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Cavefish
Match: rapgef4 (Rap guanine nucleotide exchange factor 4 [Source:NCBI gene;Acc:103034068])

HSP 1 Score: 98.5969 bits (244), Expect = 4.580e-20
Identity = 57/172 (33.14%), Postives = 92/172 (53.49%), Query Frame = 2

Query: 3095 NRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRAR 3610
             R    ++  N   FL+   +   +VV  VC   ++ SKR ++LK+ I++A  CKE  N+  FFS++ GL    +SRL  TW+++P+K  K Y + + L+D S N R  R       PP+IP   L+ KD+T  +E + T ++              L+NF+K+R++AN  R
Sbjct:  801 GRQHFKKTTANLDLFLRRFNEIQLWVVTEVCL-CSALSKRVQLLKKFIKIAAHCKEFRNLNSFFSIIMGLGNPAVSRLSQTWEKLPSKFKKFYGEFENLMDPSRNHRAYRLTVAKLDPPIIPFMPLLIKDMTFTHEGNKTFIDS-------------LVNFEKMRMIANTVR 958

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Sea Lamprey
Match: rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6959])

HSP 1 Score: 233.032 bits (593), Expect = 2.577e-63
Identity = 225/926 (24.30%), Postives = 394/926 (42.55%), Query Frame = 2

Query:  905 LRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCSDLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSK----SRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAI 3661
            LR   C      VVE   TV+++  E++  W   L G++E+ R                 ETL   + FG      E+++    + +  +DC  + I  K++ +I ++    + ++ E  + VM+ E R     G+ KG +++K T  +LI +L E H  VD T++EDF LTY  +    + + K +++     S  R K T +V+ W+ NHF + E+  ++M+F++     L RE    H   +   C+  +  R+VT+    ++      + G   R             +P    S +L     +            S L  GD+++++N  + +N+   +A  I+ KS    +TVK +   +    + + L+ +  S V             PD  ++     L L P         + K KK        S   S LKK+M + K N      K  +C+++    +RS    P    + TP                 +S+S  +    +  AE  T          G  PD                   V+KVY  D +           S Y+++S+E+ A EV++ +L E  + C +   + LCE+SV     IKQ+ + ++ + L   ++LN R+++K    +  L  +   +E+  E  ++   L   E+ATQI +  +  F+ I  +E +                              NL  R G + +  + Q F +   +  ++V + V  ET    KR K++K  +++A  C++  N    F++++GL    + RLR+ WD++P+K  K++  +Q L D S NM   R+L    S +PP+IP+  +V KDLT ++         DG  ND + E   L+NF+KLR++A   R    L    S N   A+
Sbjct:  104 LRRELCASMVFAVVEKAGTVVLRDGEELDSWCVILNGSVEISRA------------DGRTETLCMGNCFGVS-PSMEKELMTGVMKTKVDDCQFVCIAQKDYCRILNKVERNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTPERLINHLVEEHSVVDPTYVEDFLLTYRTFQPHGLDIGKRLLQWF-NDSSLRDKVTRVVLLWVNNHFNDFESDPDLMQFLENFESCLEREKMHGHLRLLNIACAAKARVRHVTVRRASRESPLGFKLDGGQDR------------GFPLYVSSLDLQSKASE------------SGLKRGDQILEVNGQNFDNVLLSQAMDIMKKSTHLSITVKNNLLSYKE--ICHRLEEEQTSGVQHKPRIADKRYSIPDLTVQ-----LELPPG------HERSKDKK------GNSMGKSKLKKLMTKSKIN--LLPTKPSRCEAQPLGSTRSRACVPCPAPLPTP---------------ASLSSSNPDLVQCHGTAELGTAP--------GDIPD------------------QVVKVYRADQS-----------SRYVMVSRESSAREVVLAALREFQV-CEAAEAYSLCEVSVSPEGFIKQRRLPDHLNKLAESIQLNARYYLKNNSQTEPLCSDEHAQELLKESQISLLQLSTLEVATQISIRDFQIFRSIEPTEYV-----------------------------ANL-FRLGGAAACEHLQAFEETLNRETFWVPSEVLRETG-LLKRVKLIKHYLKIALNCRDSRNFNSMFAIISGLSHSSVMRLRSAWDKLPSKYEKLFSDLQDLFDPSRNMAKYRNLLSSPSLQPPIIPLFPVVKKDLTFLH---------DG--NDSRVEG--LVNFEKLRMIAKEVRHVGRL---ASANQDPAV 870

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BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005082.1 (pep scaffold:Pmarinus_7.0:GL478314:141397:156611:1 gene:ENSPMAG00000004611.1 transcript:ENSPMAT00000005082.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 103.219 bits (256), Expect = 1.578e-22
Identity = 79/270 (29.26%), Postives = 133/270 (49.26%), Query Frame = 2

Query: 3164 YFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKI-DLKESSKGLSTS--------QNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRS 3937
            ++V + V +E     KR K+LK  I++A  C+E  N    F++++GL    ++RL  TW+++P K   +YR++Q L D S NM   R++   +S +PP+IP+  +V KDLT ++E + ++V  DG           ++NF+KLR++A   R    +    S+    A                A  R    +   L   S+G S S          H  R RRS+ +N +K+YE      +VK ++G++ + + D+  L+  S   EP S
Sbjct:   51 FWVASEVLAEPGQI-KRVKVLKHFIKIALHCRECKNFNSMFAIISGLSHSSVARLNGTWEKLPTKYESLYRELQDLFDPSRNMAKYRNVLSSQSLQPPLIPLFPVVKKDLTFLHEGNDSRV--DG-----------MVNFEKLRMIAKEVRQVVRM---ASVGMDAA----------------AMFRHRRKRWRSLGSISQGSSNSAVFDAIQASGHRKRARRSSLVNPRKLYEEAQMGRKVKQYLGQVNR-DVDEDSLMTRSVALEPAS 286

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BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Yeast
Match: CDC25 (Membrane bound guanine nucleotide exchange factor; also known as a GEF or GDP-release factor; indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1; thermosensitivity of the cdc25-5 mutant is functionally complemented by human RASGRF1 or by a fragment of human SOS1 comprising the CDC25-related catalytic domain [Source:SGD;Acc:S000004301])

HSP 1 Score: 49.2914 bits (116), Expect = 6.896e-6
Identity = 35/140 (25.00%), Postives = 59/140 (42.14%), Query Frame = 2

Query: 3074 AIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSCKP-PVIPMAALVTKDLT 3490
            A GT   N  G      N  +F+        FV + +  + +    R K+ +  + +A+ CKEL N     ++++ L    I RL+ TWD V  +   + + +  L+D   N    R L +S      +P   +   DLT
Sbjct: 1333 AWGTKYCNMGGSP----NITKFIANANTLTNFVSHTIVKQAD-VKTRSKLTQYFVTVAQHCKELNNFSSMTAIVSALYSSPIYRLKKTWDLVSTESKDLLKNLNNLMDSKRNFVKYRELLRSVTDVACVPFFGVYLSDLT 1467

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BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Nematostella
Match: EDO41810 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S390])

HSP 1 Score: 147.517 bits (371), Expect = 9.010e-36
Identity = 125/459 (27.23%), Postives = 215/459 (46.84%), Query Frame = 2

Query: 2582 PTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLS-CASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKS--CKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSF---KNLLYDCSINSSKAITSTENLLPEN--EGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRR-SACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
            P   + + K++    Y +I KET A E++  ++    L   ASN  + LCE++VE   +++Q+   ++ +NL   + LN+R+++K  + + +L+      ++  E +VT   L   E+A  + ++ +  F+ I   E I +   +   E S N +K E T  R                                ++VV  +C E+N   KR K++K  I++A+ CK+  NI   F++++GL    + RL+NTW+++PN+  KMY  ++ L+D S +M   RSL  S    PP+IP   ++ +DLT I               + KS  + LINF+KLR++A   R      ++ YD S           N+  ++   GA  +    ++          G+ T  +   RR  +   N KK YE  I   RV  ++ K+E ++ D+  L  MS  CEP
Sbjct:  452 PDRVVKLYKADQTYKYFMIFKETTARELVNMAVDAFGLQDLASN--YSLCEVTVEESGLVRQRRQPDSLANLADRISLNSRYYLKNNNETAQLLQGDATHDLGKECHVTLLQLKTQEVARHLTLQDFELFRAIDPREYI-YDVWEFGPEFSPNLAKFEETVNRE------------------------------TFWVVTEICGESNVV-KRMKLIKHFIKIAKYCKDCKNINSAFAIISGLGHTAVKRLKNTWEKLPNRYYKMYEDLENLMDPSRSMFKYRSLLNSEHVNPPLIPFFPVIKRDLTLIYL-------------NNKSVVDGLINFEKLRMIAREVRQVSKCHSMPYDPS-----------NMFEQDSVRGAPQSMTSTVV----------GMVTGSSAWARRSMTRDQNPKKYYEECIMSRRVLKYLEKLE-VQADEEKLREMSNTCEP 841

HSP 2 Score: 115.931 bits (289), Expect = 5.611e-26
Identity = 95/377 (25.20%), Postives = 164/377 (43.50%), Query Frame = 2

Query:  896 TQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFY----LVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERRCSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIR-NCSDLHVG----DRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGF 1999
            TQ++R + C +    VVE    +++K  E++  W   L G++ +   VEN          +    L   DSFG      E  + K Y    + +  NDC  + I   ++ +I +Q  + +  I E+ + VM+ E R +  G+ +GQV++KA   KLI +L E+H  +D TF+EDF LT+  +      +   ++       + R K T +++ W+ NH+ + E    +  ++      L  +        +   CS  +  R +++     DQ     I G                   RE        NG     +F+ +I   CS    G    D+V+++N+IS EN+T  +A  +LS S    L +K +  GF
Sbjct:    2 TQNVRRSLCAVMVFAVVEKADAIVMKDGEELDSWCVILNGSVIIE--VEN----------EPPIELHLGDSFGV-----EPSLKKMYHHGLMRTRVNDCQFVCIAQSDYYRILTQGESNIQVIEEDGEVVMVTEHRSTDGGNRQGQVVIKAKSGKLITHLVEDHSVIDPTFVEDFLLTFKTFFDQPTKICGKLLNWFLE-DDLRDKVTRVMLLWVNNHYNDFEGDHVMEDYLQAFESALEVQKMSGQLDLLLMACSVKAKSRVISLERQSHDQPWGFSIAGG------------------RE--------NG---FGIFVYKIDPECSAFTAGVRKADQVLKVNDISFENITYDKARDLLSSSIRLTLALKKNIAGF 331

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Nematostella
Match: EDO37398 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFW1])

HSP 1 Score: 102.834 bits (255), Expect = 8.340e-22
Identity = 54/144 (37.50%), Postives = 85/144 (59.03%), Query Frame = 2

Query: 3164 YFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIM 3595
            Y+V+  +C  T   SKR  +LK+ I++A  CK+  N+   F+++  L+   ISRL  TW+++PNK  K+YR++  +LD SGN R+ R +    KPPVIP   L+ KD+T IN  + T V +             L+NF+K+R++
Sbjct:  781 YWVITEICLATQ-LSKRVFLLKKFIKIASYCKDYKNLNSAFAIIMALNCAAISRLTQTWEKIPNKYKKLYRELDAILDPSGNHRVYRLVVAKMKPPVIPFMVLIMKDITIINYGNKTFVNE-------------LVNFEKMRMI 910

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Nematostella
Match: EDO35331 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLX0])

HSP 1 Score: 56.9954 bits (136), Expect = 6.984e-8
Identity = 41/148 (27.70%), Postives = 62/148 (41.89%), Query Frame = 2

Query: 3161 MYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSC--KPPVIPM------------AALVTKDLTTINEVHPTKVEDDGPENDQKSENE 3562
            M     ++  ET  T  R +++ ++I++A  C+ LGN     +LM GL    I RL+ TW  V +K  K +R +  ++  S N  L R    SC    P +P             A L  K  T      PT   D+ P  +  +  E
Sbjct:  174 MLVASEILAEET--TQARARVVSKVIQIADKCRLLGNYNSLKALMAGLQSAPIYRLKQTWKEVSSKRRKKFRHLSIIMGESDNFALYRGELSSCLANGPCLPFLGDFLTQIAQTQAYLTVKRKTQGMSTPPTSPTDETPHENSLTNGE 319

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Medaka
Match: rapgef2 (Rap guanine nucleotide exchange factor 2 [Source:NCBI gene;Acc:101158677])

HSP 1 Score: 274.248 bits (700), Expect = 7.339e-74
Identity = 259/1078 (24.03%), Postives = 482/1078 (44.71%), Query Frame = 2

Query:  788 QDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGY---STLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVS 3967
            +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV                   E L   +SFG      +E + K  + +  +DC  + I  +E+  I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L+S ++V K ++E     S  R K T +V+ W+ NHF + E    + +F++    +L +E    H   +   C+  +  R VT+    +D                               + F+L    +K + +FI  +   S      L  GD+++++N  + EN+   +A+ IL  +    +TVK            N L  K    + R    H       D+ +E  +   +  P +PK+G I    +   +  +P+          L+K  K+ KAN+     K +K   K+ ++   P  +       + ++++  +K +  +        ++S+   +      R +     +QPD+                + V++V+           K++ +S Y++I K+T A EV+V+++ E  L+ A  + + LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +++  E  ++   L   E+ATQ+ +  +  F  I  +E ID +  +  K  S                            S+  F+E +       ++V + V  E N   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K++  +Q L D S NM   R++  +++ +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+          +L   ++G+  A +      +D+ ++         H  R RRS+ +N KK+YE+     +VK ++  +  +E ++  L  +S +CE  S I+ L  N  
Sbjct:  265 RDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRKQLCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYP------------DSRTEVLCMGNSFGVSPTMEKEYM-KGVMKTKVDDCQFVCIAQQEYCCILNQVEKNMQRVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTAERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFHDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENMLEKEKMCGHLRLLNIACAAKAKPRLVTLTKPSRDSP-----------------------------LGFSLLGGQEKGSRIFIDAVEPGSKAAEVGLKRGDQILEVNGQNFENVQLSKASEILKNNTHLSITVK-----------TNLLVFKEL--LTRPEHDH-------DTDVEDDHDRKNGAPHQPKIGDI----KKASRHSIPDLAVDVEQVMGLEKASKKAKANTVGGRNKLKKIFDKTLTSILPPKPYNDVCVGQSQDDSILGMKQSKQIPPALPVSGNLSSSNPDLLQSHHRILD--FNNQPDM---------------SDQVLRVF-----------KADQQSRYIMIGKDTTAKEVVVQAIREFALTAAPEA-YSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQDLLREGQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFKRRSKTGS---------------------------ASLKRFEEAIN---HETFWVASEVTREPNQL-KRMKIIKHFIKIALHCRECKNFSSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFGDLQDLFDPSRNMAKYRNVLNNQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALMFRTRKKKWRSLGSLSQGSANAAV------LDVNQTG-------GHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNL-SLETNEESLQTLSLQCE--SSISTLPKNTG 1183

HSP 2 Score: 63.5438 bits (153), Expect = 2.355e-9
Identity = 35/128 (27.34%), Postives = 63/128 (49.22%), Query Frame = 2

Query:  113 SNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSTIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFY 496
            S + N    A+  +P  R+++++EI+  YL  +  L     +   +    V+Y+  + N  +    D    WY +L GSV I  +MFLP +SF  +   +     ECIVLE + +++  Y + N  ++
Sbjct:    3 SYVDNRFRQAVMMNPAERTQQDLEIVYSYLHGMEALSNLREHQLRMMCETVRYERHEANEVLYCPEDIGSCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDYMDENEEYF 130

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Medaka
Match: rapgef2 (Rap guanine nucleotide exchange factor 2 [Source:NCBI gene;Acc:101158677])

HSP 1 Score: 272.707 bits (696), Expect = 1.803e-73
Identity = 260/1082 (24.03%), Postives = 481/1082 (44.45%), Query Frame = 2

Query:  788 QDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEV----RRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGY---STLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAIT------STENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVS 3967
            +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV     RT                E L   +SFG      +E + K  + +  +DC  + I  +E+  I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L+S ++V K ++E     S  R K T +V+ W+ NHF + E    + +F++    +L +E    H   +   C+  +  R VT+    +D                               + F+L    +K + +FI  +   S      L  GD+++++N  + EN+   +A+ IL  +    +TVK            N L  K    + R    H       D+ +E  +   +  P +PK+G I    +   +  +P+          L+K  K+ KAN+     K +K   K+ ++   P  +       + ++++  +K +  +        ++S+   +      R +     +QPD+                + V++V+  D            +S Y++I K+T A EV+V+++ E  L+ A  + + LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +++  E  ++   L   E+ATQ+ +  +  F  I  +E ID +  +  K                             S S+  F+E +       ++V + V  E N   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K++  +Q L D S NM   R++  +++ +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+          +L   ++G+  A + ++             + +  H  R RRS+ +N KK+YE+     +VK ++  +  +E ++  L  +S +CE  S I+ L  N  
Sbjct:  104 RDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRKQLCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDSRT----------------EVLCMGNSFGVSPTMEKEYM-KGVMKTKVDDCQFVCIAQQEYCCILNQVEKNMQRVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTAERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFHDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENMLEKEKMCGHLRLLNIACAAKAKPRLVTLTKPSRDSP-----------------------------LGFSLLGGQEKGSRIFIDAVEPGSKAAEVGLKRGDQILEVNGQNFENVQLSKASEILKNNTHLSITVK-----------TNLLVFKEL--LTRPEHDH-------DTDVEDDHDRKNGAPHQPKIGDI----KKASRHSIPDLAVDVEQVMGLEKASKKAKANTVGGRNKLKKIFDKTLTSILPPKPYNDVCVGQSQDDSILGMKQSKQIPPALPVSGNLSSSNPDLLQSHHRIL--DFNNQPDM---------------SDQVLRVFKAD-----------QQSRYIMIGKDTTAKEVVVQAIREFALTAAPEA-YSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQDLLREGQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFKRRSKTG---------------------------SASLKRFEEAIN---HETFWVASEVTREPNQL-KRMKIIKHFIKIALHCRECKNFSSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFGDLQDLFDPSRNMAKYRNVLNNQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALMFRTRKKKWRSLGSLSQGSANAAVLDV-------------NQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNL-SLETNEESLQTLSLQCE--SSISTLPKNTG 1022

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Medaka
Match: rapgef2 (Rap guanine nucleotide exchange factor 2 [Source:NCBI gene;Acc:101158677])

HSP 1 Score: 266.544 bits (680), Expect = 1.183e-71
Identity = 257/1074 (23.93%), Postives = 469/1074 (43.67%), Query Frame = 2

Query:  788 QDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEV----RRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKXXXXXXXXXXXXXXXXVIKVYYKDPTDS-ISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVS 3967
            +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV     RT                E L   +SFG      +E + K  + +  +DC  + I  +E+  I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L+S ++V K ++E     S  R K T +V+ W+ NHF + E    + +F++    +L +E    H   +   C+  +  R VT+    +D                               + F+L    +K + +FI  +   S      L  GD+++++N  + EN+   +A+ IL  +    +TVK            N L + +    DR                    +  P +PK+G I    +   +  +P+          L+K  K+ KAN+     K +K   K+ ++   P  +       + ++++  +K +  +        ++S+   +      R +     +QPD+                + V++V+  D     I IGK            +T A EV+V+++ E  L+ A  + + LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +++  E  ++   L   E+ATQ+ +  +  F  I  +E ID +  +  K                             S S+  F+E +       ++V + V  E N   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K++  +Q L D S NM   R++  +++ +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+                F    LS+     +   ++ +  H  R RRS+ +N KK+YE+     +VK ++  +  +E ++  L  +S +CE  S I+ L  N  
Sbjct:  104 RDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRKQLCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDSRT----------------EVLCMGNSFGVSPTMEKEYM-KGVMKTKVDDCQFVCIAQQEYCCILNQVEKNMQRVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTAERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFHDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENMLEKEKMCGHLRLLNIACAAKAKPRLVTLTKPSRDSP-----------------------------LGFSLLGGQEKGSRIFIDAVEPGSKAAEVGLKRGDQILEVNGQNFENVQLSKASEILKNNTHLSITVK-----------TNLLGKDDH---DRK-------------------NGAPHQPKIGDI----KKASRHSIPDLAVDVEQVMGLEKASKKAKANTVGGRNKLKKIFDKTLTSILPPKPYNDVCVGQSQDDSILGMKQSKQIPPALPVSGNLSSSNPDLLQSHHRIL--DFNNQPDM---------------SDQVLRVFKADQQSRYIMIGK------------DTTAKEVVVQAIREFALTAAPEA-YSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQDLLREGQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFKRRSKTG---------------------------SASLKRFEEAIN---HETFWVASEVTREPNQL-KRMKIIKHFIKIALHCRECKNFSSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFGDLQDLFDPSRNMAKYRNVLNNQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALM---------------FRTRSLSQGSANAAVLDVNQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNL-SLETNEESLQTLSLQCE--SSISTLPKNTG 998

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Medaka
Match: rapgef6 (Rap guanine nucleotide exchange factor 6 [Source:NCBI gene;Acc:101165993])

HSP 1 Score: 166.392 bits (420), Expect = 1.205e-40
Identity = 121/460 (26.30%), Postives = 224/460 (48.70%), Query Frame = 2

Query: 2558 VIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEP 3931
             + +YY  P   I + K++ +S Y+IISK+T A +V+  ++ E  LS A  S + LCE+SV    + KQ+ + +  S L   ++LN R+++K    +  L  + D +++  E  ++   L   E+A Q+ +  +  F+ I  +E +D +                      F + + L        S  N + F ++  +  ++V   +  E NS  KR + +K  I++A  CKE  N    F++++GLD   ++RLR++W+++P+K  K++  +Q + D S NM   R++   +S +PP+IP+  ++ KDLT  +E + + V  DG           L+NF+KLR++A   R    +             ++ N+ P      + F +  LS+     +   +    +    RRS+ +N KK+YE+     +VK ++  +  +E D+     MS +CEP
Sbjct:  784 ALGLYYI-PDQVIRVFKADQQSCYIIISKDTTAKDVVAHAVNEFGLSAAPES-YSLCEVSVSPEGVTKQRRLPDQLSKLADRIQLNGRYYLKNNMDTETLCSDDDAQDLLKESQISLLQLSTMEVAAQLSMRDFELFRNIEPTEYVDDL----------------------FKLDSPL--------SRGNLKRFEEVMNQETFWVATEILREPNSV-KRMRTIKHFIKIALHCKECKNFNSMFAIISGLDLPPVARLRSSWEKLPSKYAKLFGDLQDVFDPSRNMAKYRNMLSSQSMQPPIIPLFPVIKKDLTFFHEGNDSSV--DG-----------LVNFEKLRMIAKEIRHVVRM-------------TSANMDP-----ALMFRQRSLSQGSTNSNMLDVQGGAHKKRVRRSSLLNAKKLYEDAQMARKVKQYLSNL-TVETDEEKHQIMSLQCEP 1178

HSP 2 Score: 127.487 bits (319), Expect = 7.692e-29
Identity = 100/404 (24.75%), Postives = 179/404 (44.31%), Query Frame = 2

Query:  788 QDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            +D +++ L+K  ADR   + E ++  +  +P F+  T S+R   CK+   +VVE    V+++  +++ +W   L G +E+                   ETL   +SFG      E+Q     + +  +DC  + I  +++ +I +       ++ E  + VM+ E R     G+ KG +++K T  +LI +L E    VD T+IEDF LTY  +L+S + V K ++E   + S  +   T IV+ W+ NHF + E    + +F++     L     + H   +   C+  +  R +T+                 SR S                + F L    ++   +F+  +   S      L  GD++++IN  S EN++  +A  IL  +    LTVK
Sbjct:  285 RDVVRECLEKDPADRHDDDIEQLLEFMHQLPAFANMTMSVRRELCKVMVFEVVEQAGHVILRDKQELDNWRVILNGAVEISYP------------DGREETLCMGNSFGIS-PSLEKQYMCGEVRTKGDDCQFVCIAKEDYWRILNHVEKNTHKVEEEGEIVMVKEHRELDRSGTRKGHIVIKGTPERLIMHLVEEPSVVDPTYIEDFLLTYRTFLSSPMEVGKKLLEWFQKDS-LQDTVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKHLEATKMKGHLRLLNIACAAKAKLRQITLQ--------------KASRESP---------------LHFKLLGGSERGFGIFVEMVEEGSKAAETGLKRGDQIMEINGQSFENISFSKALDILKNNTHLSLTVK 645

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Medaka
Match: rapgef2 (Rap guanine nucleotide exchange factor 2 [Source:NCBI gene;Acc:101158677])

HSP 1 Score: 164.466 bits (415), Expect = 4.114e-40
Identity = 125/461 (27.11%), Postives = 228/461 (49.46%), Query Frame = 2

Query: 2594 ISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSL--HKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNR-RRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVS 3967
            + + K++ +S Y++I K+T A EV+V+++ E  L+ A  + + LCE+SV    +IKQ+ + +  S L   ++L+ R+++K    +  L  + D +++  E  ++   L   E+ATQ+ +  +  F  I  +E ID +  +  K  S                            S+  F+E +       ++V + V  E N   KR KI+K  I++A  C+E  N    F++++GL+   +SRLR TW+++P+K  K++  +Q L D S NM   R++  +++ +PP+IP+  ++ KDLT ++E + +KV  DG           L+NF+KLR++A   R    +    S+N   A+                F    LS+     +   ++ +  H  R RRS+ +N KK+YE+     +VK ++  +  +E ++  L  +S +CE  S I+ L  N  
Sbjct:  786 LRVFKADQQSRYIMIGKDTTAKEVVVQAIREFALTAAPEA-YSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQDLLREGQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFKRRSKTGS---------------------------ASLKRFEEAIN---HETFWVASEVTREPNQL-KRMKIIKHFIKIALHCRECKNFSSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFGDLQDLFDPSRNMAKYRNVLNNQNLQPPIIPLFPVIKKDLTFLHEGNDSKV--DG-----------LVNFEKLRMIAKEIRHVGRM---ASVNMDPALM---------------FRTRSLSQGSANAAVLDVNQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNL-SLETNEESLQTLSLQCE--SSISTLPKNTG 1180

HSP 2 Score: 141.739 bits (356), Expect = 3.774e-33
Identity = 102/404 (25.25%), Postives = 182/404 (45.05%), Query Frame = 2

Query:  788 QDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERR-CSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCS-----DLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVK 1981
            +D ++D L+K   DR+  + E ++  +  +P F+  T S+R   C +    VVE   T+++   E++  W   L G++EV                   E L   +SFG      E++  K  + +  +DC  + I  +E+  I +Q    + ++ E  + VM+ E R     G+ KG +++K T  +L  +L E H  VD T+IEDF LTY  +L+S ++V K ++E     S  R K T +V+ W+ NHF + E    + +F++    +L +E    H   +   C+  +  R VT+    +D                               + F+L    +K + +FI  +   S      L  GD+++++N  + EN+   +A+ IL  +    +TVK
Sbjct:  265 RDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRKQLCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYP------------DSRTEVLCMGNSFGVS-PTMEKEYMKGVMKTKVDDCQFVCIAQQEYCCILNQVEKNMQRVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTAERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFHDPS-LRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENMLEKEKMCGHLRLLNIACAAKAKPRLVTLTKPSRDSP-----------------------------LGFSLLGGQEKGSRIFIDAVEPGSKAAEVGLKRGDQILEVNGQNFENVQLSKASEILKNNTHLSITVK 625

HSP 3 Score: 63.5438 bits (153), Expect = 2.335e-9
Identity = 35/128 (27.34%), Postives = 63/128 (49.22%), Query Frame = 2

Query:  113 SNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSTIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFY 496
            S + N    A+  +P  R+++++EI+  YL  +  L     +   +    V+Y+  + N  +    D    WY +L GSV I  +MFLP +SF  +   +     ECIVLE + +++  Y + N  ++
Sbjct:    3 SYVDNRFRQAVMMNPAERTQQDLEIVYSYLHGMEALSNLREHQLRMMCETVRYERHEANEVLYCPEDIGSCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDYMDENEEYF 130

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BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Planmine SMEST
Match: SMESG000009223.1 (SMESG000009223.1)

HSP 1 Score: 2737.98 bits (7096), Expect = 0.000e+0
Identity = 1419/1426 (99.51%), Postives = 1423/1426 (99.79%), Query Frame = 2

Query:  110 MSNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSTIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFYPCKCTKNTFSDSISKIKLNQKSLNKXXXXXXXXXXXXXXXKISNGDSESINFKI-DSNSSQQLRRKAASGXXXXXXXXXXXXXXXXXXXXFTFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERRCSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCSDLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVSRATMAGILTSPTGNYDREEILSIRNXXXXXXXXXXXXQTNYXXXXXXXXXXXXXNNYRINQKYSRINASTPLSGQLQYLEPSSGSQRRHILPPPYSSIGTIPPIPPRRKSSVVSGEKNRSFSNPLSNGKSIFACCIFQV 4384
            MSNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDS IYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFYPCKCTKNTFSDSISKIKLNQKSLNKSQTGSDTSSGYSGSDKISNGDSESINFKI DSNSSQQLRRKAASGSNNLDTLTLDSDSEEDDLSDFTFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQ+TDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIME RCSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCSDLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKSAFFNSGEFSSS+CESVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNV+FFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPG+PFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVSRATMAGILTSPTGNYDREEILSIRNSTGGSISSKESSQTNYSSGSEQLSELSGQNNYRINQKYSRINASTPLSGQLQYLEPSSGSQRRHILPPPYSSIGTIPPIPPRRKSSVVSGEKNRSFSNPLSNGKSIFACCIFQV
Sbjct:    1 MSNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSIIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFYPCKCTKNTFSDSISKIKLNQKSLNKSQTGSDTSSGYSGSDKISNGDSESINFKIVDSNSSQQLRRKAASGSNNLDTLTLDSDSEEDDLSDFTFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQSTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMELRCSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCSDLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKSAFFNSGEFSSSTCESVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVSFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGQPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVSRATMAGILTSPTGNYDREEILSIRNSTGGSISSKESSQTNYSSGSEQLSELSGQNNYRINQKYSRINASTPLSGQLQYLEPSSGSQRRHILPPPYSSIGTIPPIPPRRKSSVVSGEKNRSFSNPLSNGKSIFACCIFQV 1426

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Planmine SMEST
Match: SMESG000009223.1 (SMESG000009223.1)

HSP 1 Score: 2714.1 bits (7034), Expect = 0.000e+0
Identity = 1407/1414 (99.50%), Postives = 1411/1414 (99.79%), Query Frame = 2

Query:  110 MSNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSTIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFYPCKCTKNTFSDSISKIKLNQKSLNKXXXXXXXXXXXXXXXKISNGDSESINFKI-DSNSSQQLRRKAASGXXXXXXXXXXXXXXXXXXXXFTFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERRCSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCSDLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVSRATMAGILTSPTGNYDREEILSIRNXXXXXXXXXXXXQTNYXXXXXXXXXXXXXNNYRINQKYSRINASTPLSGQLQYLEPSSGSQRRHILPPPYSSIGTIPPIPPRRKSSVVSGEKNRSFSNPLSN 4348
            MSNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDS IYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFYPCKCTKNTFSDSISKIKLNQKSLNKSQTGSDTSSGYSGSDKISNGDSESINFKI DSNSSQQLRRKAASGSNNLDTLTLDSDSEEDDLSDFTFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQ+TDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIME RCSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCSDLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKSAFFNSGEFSSS+CESVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNV+FFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPG+PFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVSRATMAGILTSPTGNYDREEILSIRNSTGGSISSKESSQTNYSSGSEQLSELSGQNNYRINQKYSRINASTPLSGQLQYLEPSSGSQRRHILPPPYSSIGTIPPIPPRRKSSVVSGEKNRSFSNPLSN
Sbjct:    1 MSNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSIIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFYPCKCTKNTFSDSISKIKLNQKSLNKSQTGSDTSSGYSGSDKISNGDSESINFKIVDSNSSQQLRRKAASGSNNLDTLTLDSDSEEDDLSDFTFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQSTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMELRCSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCSDLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKSAFFNSGEFSSSTCESVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVSFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGQPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVSRATMAGILTSPTGNYDREEILSIRNSTGGSISSKESSQTNYSSGSEQLSELSGQNNYRINQKYSRINASTPLSGQLQYLEPSSGSQRRHILPPPYSSIGTIPPIPPRRKSSVVSGEKNRSFSNPLSN 1414

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Planmine SMEST
Match: SMESG000009223.1 (SMESG000009223.1)

HSP 1 Score: 2713.33 bits (7032), Expect = 0.000e+0
Identity = 1407/1413 (99.58%), Postives = 1411/1413 (99.86%), Query Frame = 2

Query:  110 MSNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSTIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFYPCKCTKNTFSDSISKIKLNQKSLNKXXXXXXXXXXXXXXXKISNGDSESINFKIDSNSSQQLRRKAASGXXXXXXXXXXXXXXXXXXXXFTFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERRCSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCSDLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVSRATMAGILTSPTGNYDREEILSIRNXXXXXXXXXXXXQTNYXXXXXXXXXXXXXNNYRINQKYSRINASTPLSGQLQYLEPSSGSQRRHILPPPYSSIGTIPPIPPRRKSSVVSGEKNRSFSNPLSN 4348
            MSNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDS IYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFYPCKCTKNTFSDSISKIKLNQKSLNKSQTGSDTSSGYSGSDKISNGDSESINFKIDSNSSQQLRRKAASGSNNLDTLTLDSDSEEDDLSDFTFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQ+TDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIME RCSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCSDLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKSAFFNSGEFSSS+CESVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNV+FFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPG+PFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVSRATMAGILTSPTGNYDREEILSIRNSTGGSISSKESSQTNYSSGSEQLSELSGQNNYRINQKYSRINASTPLSGQLQYLEPSSGSQRRHILPPPYSSIGTIPPIPPRRKSSVVSGEKNRSFSNPLSN
Sbjct:    1 MSNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSIIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFYPCKCTKNTFSDSISKIKLNQKSLNKSQTGSDTSSGYSGSDKISNGDSESINFKIDSNSSQQLRRKAASGSNNLDTLTLDSDSEEDDLSDFTFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQSTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMELRCSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCSDLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKSAFFNSGEFSSSTCESVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVSFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGQPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVSRATMAGILTSPTGNYDREEILSIRNSTGGSISSKESSQTNYSSGSEQLSELSGQNNYRINQKYSRINASTPLSGQLQYLEPSSGSQRRHILPPPYSSIGTIPPIPPRRKSSVVSGEKNRSFSNPLSN 1413

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Planmine SMEST
Match: SMESG000009223.1 (SMESG000009223.1)

HSP 1 Score: 2710.25 bits (7024), Expect = 0.000e+0
Identity = 1407/1414 (99.50%), Postives = 1411/1414 (99.79%), Query Frame = 2

Query:  110 MSNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSTIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFYPCKCTKNTFSDSISKIKLNQKSLNKXXXXXXXXXXXXXXXKISNGDSESINFKI-DSNSSQQLRRKAASGXXXXXXXXXXXXXXXXXXXXFTFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERRCSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCSDLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKXXXXXXXXXXXXXXXXVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVSRATMAGILTSPTGNYDREEILSIRNXXXXXXXXXXXXQTNYXXXXXXXXXXXXXNNYRINQKYSRINASTPLSGQLQYLEPSSGSQRRHILPPPYSSIGTIPPIPPRRKSSVVSGEKNRSFSNPLSN 4348
            MSNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDS IYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFYPCKCTKNTFSDSISKIKLNQKSLNKSQTGSDTSSGYSGSDKISNGDSESINFKI DSNSSQQLRRKAASGSNNLDTLTLDSDSEEDDLSDFTFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQ+TDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIME RCSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCSDLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKSAFFNSGEFSSS+CESVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNV+FFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPG+PFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVSRATMAGILTSPTGNYDREEILSIRNSTGGSISSKESSQTNYSSGSEQLSELSGQNNYRINQKYSRINASTPLSGQLQYLEPSSGSQRRHILPPPYSSIGTIPPIPPRRKSSVVSGEKNRSFSNPLSN
Sbjct:    1 MSNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAHIVQYKTFKRNNCIPRQSDSIIYWYHILYGSVLIGSAMFLPNNSFWIKDKSNKETQYECIVLEDTGVLLFPYDNCNHSFYPCKCTKNTFSDSISKIKLNQKSLNKSQTGSDTSSGYSGSDKISNGDSESINFKIVDSNSSQQLRRKAASGSNNLDTLTLDSDSEEDDLSDFTFNEISCQDHIKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQSTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMELRCSADGSTKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCSDLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKSAFFNSGEFSSSTCESVIKVYYKDPTDSISIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGKLIDNVDIEEINSEMNVSFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGQPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIAFIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKYFIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVSRATMAGILTSPTGNYDREEILSIRNSTGGSISSKESSQTNYSSGSEQLSELSGQNNYRINQKYSRINASTPLSGQLQYLEPSSGSQRRHILPPPYSSIGTIPPIPPRRKSSVVSGEKNRSFSNPLSN 1414

[Close]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Planmine SMEST
Match: SMESG000060051.1 (SMESG000060051.1)

HSP 1 Score: 270.781 bits (691), Expect = 7.371e-74
Identity = 264/988 (26.72%), Postives = 462/988 (46.76%), Query Frame = 2

Query:  776 EISCQDH--IKDILQKPSADRSTQENEVIMNVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCLQGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYLVSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERRC--SADGSTK-GQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKAIIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRENEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKAIMTIENYPREFMSFNLF-RNGQKLNNLFISQIRNCSDLHVGDRVIQINNISEENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKN----QSPVDRSSLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQSATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAFNENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRKXXXXXXXXXXXXXXXXV-------IKVYYKD----PTDSI--SIGKSNVKSVYLIISKETEALEVIVKSLVELNLSCASNSEFCLCEISV-ETGPIIKQKIIKENTSNLMSIVKLNNRFFIKRRDFSGK-LIDNVDIEEINSEM-NVTFFDLPVCELATQIFVEGYNAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGKSESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCKELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGNMRLLRSLHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSENEYLINFDKLRIMANRARSFKNLLYDCSINSSKAI 3661
            E+   D+  IK  LQ  S  RS  E   +  ++++I  F  +  S     C+ A+L  ++     ++KK      W + L G+L +                +    L   D +G+ L   +    +  + S S+ C LM+I+  +   I SQE  T T   + ++T++ +   C  ++D S     VL K T+  LI+ L      V   F+EDFF+TY ++      + ++I+  +     + K   +I+++W+  ++KE E +   M F++ +  +L  +  +++   +Y TC+ H++ R+V                    R+S KD     I + PR+   F  +  N QK + L +           GD ++ I + S   +T      +  + +   L V+ DP G++   +VN L         +P    S +HS         I    S       +G   P ++    K  P+ +    TS     + +  K    +++E K+K  SKSR     P+   +S        ++S L  ++N    S    S+S I  +  + +++  R   GS P++ KS      +    S           I++Y+KD     ++S+  S  KS +K ++++I       EVI+ +L++LNL+  S+SEF L E+ V E+  +I +KI+K  ++NL   +K+ ++F++K   F G  LI   + E++  E  + T   LP+ E A ++F+  +      + +++I +VT                      A    L      +++ N F ++++L + Y  +V++ +CSE     KR K++   IR+A   + +G+I++FFSL++GLD  EISRL  TWDRV N D K+++ ++ +L+V+GN+R LR L +    P IP+ ALV KDLT I E +PT VE  G  N  +  N+ LINFDK+R MA  +R+F N +  C  + SK I
Sbjct:   78 EVLLHDYSVIKRCLQTDSCQRSDSEVNKLSQLLESIKEFRYFNSSELEMMCQRAKLLTIDEINRKIVKKFSTKDKWFFILNGSLRLE--------------GETTTILIPGDFYGSILDTPDLLTEENNVYSNSDYCDLMVISKDDL--IPSQELVTKTN--DEDRTIIAVYEPCINNSDLSKNFSYVLTKGTLDVLIKKL-TTKRNVHREFVEDFFVTYKIFNPDPFSIMESILSNLTSDLNESKAKFEILLQWLSQNYKEFEKEEAKMSFLNQIIEILSMQKNQDYLLFLYDTCTNHASARSVR------------------CRLSFKD----NIVSVPRDSDQFVFYIHNLQKEHKLLMD----------GDIILAIEDYSHHAITIDLVKKLCDELKELSLIVRNDPLGYHEN-VVNDLSFDTCSIYSTPSTVYSQSHS-------DKISDSVSISTNDSDVGSPAPTDKSPNNKKRPSLIPNFLTSIQNGTVGRFFKNPKYYSNELKRKY-SKSRPMTLVPNNRSIS--------DVSSLDFSTNFQRQSM---SVSTISIQRFSRRIKHQRKSAGSNPEIIKSFDDKDLDSDLYSFYRTNQKQEFPIRIYFKDIFIYRSESLHNSSNKSELKFIHIMIKPIMPVSEVIIIALLKLNLASVSSSEFFLVEVKVDESNMMIHEKILKPASTNLK--LKVQSKFYLKHSSFIGSSLILQKEAEKMIEEFQSFTILKLPIVEFAIELFIRSHKCICNFNATDLITYVT----------------------ASKATLKTHRLSNQTENEFDKYIQLSDFYKNWVISEICSEQMCPMKRAKLISFFIRLASKAQIIGHIDLFFSLISGLDSTEISRLSQTWDRVSNSDKKLFKNLKNILNVTGNLRHLRILQQKITSPFIPVTALVVKDLTMIEEANPTYVE--GKINGLQV-NKNLINFDKMRKMARLSRNFINSICTCDKDKSKPI 967

The following BLAST results are available for this feature:

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Human
BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Celegans
BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Fly
BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Zebrafish
BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Xenopus
BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Mouse
BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. UniProt/SwissProt
BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. TrEMBL
BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Cavefish
BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Sea Lamprey
BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Yeast
BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Nematostella
BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Medaka
BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Planmine SMEST

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
RAPGEF2	9.490e-45	27.81	Rap guanine nucleotide exchange factor 2 [Source:H...	[more]
RAPGEF2	6.779e-44	27.45	Rap guanine nucleotide exchange factor 2 [Source:H...	[more]
RAPGEF2	7.375e-44	27.45	Rap guanine nucleotide exchange factor 2 [Source:H...	[more]
RAPGEF6	1.498e-40	26.99	Rap guanine nucleotide exchange factor 6 [Source:H...	[more]
RAPGEF6	2.916e-40	26.99	Rap guanine nucleotide exchange factor 6 [Source:H...	[more]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pxf-1	6.909e-38	27.25	Rap guanine nucleotide exchange factor [Source:Un...	[more]
pxf-1	6.909e-38	27.25	Rap guanine nucleotide exchange factor [Source:Un...	[more]
pxf-1	8.032e-38	26.98	Rap guanine nucleotide exchange factor [Source:Un...	[more]
pxf-1	8.032e-38	26.98	Rap guanine nucleotide exchange factor [Source:Un...	[more]
pxf-1	9.900e-38	27.25	Rap guanine nucleotide exchange factor [Source:Un...	[more]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PDZ-GEF	4.891e-41	28.98	gene:FBgn0265778 transcript:FBtr0079249	[more]
PDZ-GEF	8.113e-41	28.98	gene:FBgn0265778 transcript:FBtr0333242	[more]
PDZ-GEF	8.113e-41	28.98	gene:FBgn0265778 transcript:FBtr0300038	[more]
PDZ-GEF	9.380e-41	28.98	gene:FBgn0265778 transcript:FBtr0300039	[more]
Epac	7.919e-22	26.13	gene:FBgn0085421 transcript:FBtr0112636	[more]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rapgef2	8.702e-42	27.84	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
rapgef2	4.178e-41	27.25	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
rapgef2	4.676e-41	27.47	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
rapgef2	4.915e-41	27.47	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
rapgef2	5.303e-41	27.47	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rapgef2	1.138e-75	24.79	cathepsin K-like [Source:Xenbase;Acc:XB-GENE-98681...	[more]
rapgef2	1.773e-75	24.51	cathepsin K-like [Source:Xenbase;Acc:XB-GENE-98681...	[more]
rapgef2	1.929e-75	24.51	cathepsin K-like [Source:Xenbase;Acc:XB-GENE-98681...	[more]
rapgef2	2.211e-75	24.63	cathepsin K-like [Source:Xenbase;Acc:XB-GENE-98681...	[more]
rapgef2	2.597e-75	24.42	cathepsin K-like [Source:Xenbase;Acc:XB-GENE-98681...	[more]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Rapgef2	6.566e-44	27.45	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
Rapgef2	7.727e-44	27.45	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
Rapgef2	1.110e-43	27.45	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
Rapgef6	8.293e-43	27.19	Rap guanine nucleotide exchange factor (GEF) 6 [So...	[more]
Rapgef6	1.639e-42	27.21	Rap guanine nucleotide exchange factor (GEF) 6 [So...	[more]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9Y4G8\|RPGF2_HUMAN	3.256e-43	27.45	Rap guanine nucleotide exchange factor 2 OS=Homo s...	[more]
sp\|Q8CHG7\|RPGF2_MOUSE	5.405e-43	27.45	Rap guanine nucleotide exchange factor 2 OS=Mus mu...	[more]
sp\|F1M386\|RPGF2_RAT	5.736e-43	27.45	Rap guanine nucleotide exchange factor 2 OS=Rattus...	[more]
sp\|F1PBJ0\|RPGF2_CANLF	9.478e-43	27.45	Rap guanine nucleotide exchange factor 2 OS=Canis ...	[more]
sp\|F1MSG6\|RPGF2_BOVIN	1.211e-42	27.67	Rap guanine nucleotide exchange factor 2 OS=Bos ta...	[more]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A061QLK9	3.745e-74	24.82	Putative rap guanine nucleotide exchange factor OS...	[more]
A0A087T7I6	7.880e-73	24.40	Rap guanine nucleotide exchange factor 2 (Fragment...	[more]
A0A1U8DQ84	2.917e-72	24.70	rap guanine nucleotide exchange factor 6 isoform X...	[more]
A0A553MNC9	8.746e-72	24.50	Uncharacterized protein OS=Danionella translucida ...	[more]
A0A3B4ENE6	9.060e-72	24.18	Rap guanine nucleotide exchange factor (GEF) 2 OS=...	[more]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rapgef2	7.174e-75	24.08	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
rapgef2	5.075e-69	24.21	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
rapgef6	1.426e-42	27.27	Rap guanine nucleotide exchange factor (GEF) 6 [So...	[more]
si:dkey-253i9.4	5.585e-33	28.18	si:dkey-253i9.4 [Source:ZFIN;Acc:ZDB-GENE-090313-2...	[more]
rapgef4	4.580e-20	33.14	Rap guanine nucleotide exchange factor 4 [Source:N...	[more]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
rapgef2	2.577e-63	24.30	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
ENSPMAT00000005082.1	1.578e-22	29.26	pep scaffold:Pmarinus_7.0:GL478314:141397:156611:1...	[more]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
CDC25	6.896e-6	25.00	Membrane bound guanine nucleotide exchange factor;...	[more]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3


Match Name	E-value	Identity	Description
EDO41810	9.010e-36	27.23	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37398	8.340e-22	37.50	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35331	6.984e-8	27.70	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rapgef2	7.339e-74	24.03	Rap guanine nucleotide exchange factor 2 [Source:N...	[more]
rapgef2	1.803e-73	24.03	Rap guanine nucleotide exchange factor 2 [Source:N...	[more]
rapgef2	1.183e-71	23.93	Rap guanine nucleotide exchange factor 2 [Source:N...	[more]
rapgef6	1.205e-40	26.30	Rap guanine nucleotide exchange factor 6 [Source:N...	[more]
rapgef2	4.114e-40	27.11	Rap guanine nucleotide exchange factor 2 [Source:N...	[more]

BLAST of rap guanine nucleotide exchange factor 2 isoform X2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000009223.1	0.000e+0	99.51	SMESG000009223.1	[more]
SMESG000009223.1	0.000e+0	99.50	SMESG000009223.1	[more]
SMESG000009223.1	0.000e+0	99.58	SMESG000009223.1	[more]
SMESG000009223.1	0.000e+0	99.50	SMESG000009223.1	[more]
SMESG000060051.1	7.371e-74	26.72	SMESG000060051.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30025424 ID=SMED30025424|Name=rap guanine nucleotide exchange factor 2 isoform X2|organism=Schmidtea mediterranea sexual|type=transcript|length=5380bp
CCGATCTTGTTGTTTAAGTAAATCAGTTTGTTAAATTTAAAACCCAAATA
TTTAAAAATACTTATTGGGAGTAACTATTTATTGAATATTTTGCAAAAGT
TACAAATATATGAGTAATATTTCGAATTCGTTAATATGCGCATTAGAGGA
AGATCCAAAATTTCGATCAAAAGAAAATATTGAAATCATCGTGAAATATT
TAATGCAAATTTCTGAGCTAGAAAAATGTGACAATAATGACTATACATTA
TGTGCCCATATTGTCCAGTATAAAACATTTAAAAGAAACAATTGTATACC
TCGCCAATCAGATTCAACAATATATTGGTATCATATTTTATATGGATCTG
TCTTGATTGGATCAGCAATGTTTCTACCAAACAACAGTTTCTGGATTAAG
GACAAAAGCAATAAAGAAACACAATATGAGTGCATTGTTTTAGAAGACAC
AGGTGTGCTCTTATTTCCTTACGATAATTGCAATCACTCATTTTATCCAT
GTAAATGTACAAAGAATACATTCAGTGATTCCATATCAAAAATAAAATTA
AATCAAAAGTCTCTGAACAAGTCTCAAACCGGAAGTGACACATCTAGTGG
ATATTCCGGTTCAGACAAGATCTCCAATGGTGACAGCGAGTCCATCAATT
TCAAAATTGATTCAAACAGCAGTCAGCAGTTGAGACGCAAAGCAGCTTCC
GGTAGTAATAATCTCGATACTCTGACTTTGGATTCCGACAGTGAAGAAGA
TGATTTATCAGACTTCACGTTTAATGAGATCAGTTGCCAGGATCATATCA
AAGACATTTTACAAAAACCATCGGCCGACAGATCAACACAAGAGAACGAA
GTCATCATGAATGTCATACAAAACATTCCGCTTTTCTCTCTATGGACCCA
ATCATTACGTTGTGCCGCTTGTAAATTGGCCCGACTTCAAGTGGTTGAGA
ACACTCAAACTGTCTTAATCAAAAAAGACGAAAAAATGACCGATTGGATA
TATTGTTTACAAGGAACATTAGAGGTCCGAAGAACAGTTGAAAATCTTAA
CCAGAACACTGATAAAAATCTAAGTGATGTTCTTGAAACCCTTCGATATA
GTGATAGTTTTGGTGCAGATTTACGTAAGTCAGAAGAACAGATCAGTAAA
TTTTATTTGGTATCCACATCAAATGATTGCTGGTTGATGCTCATTAACTG
GAAAGAATTCATGAAAATTAAGTCCCAAGAACCGACAACTCTTACTCAAA
TAATTGAAAATAACAAAACAGTAATGATTATGGAACGTCGATGCAGTGCT
GATGGATCAACAAAGGGACAAGTTTTAGTTAAAGCTACAGTCAGAAAATT
AATAGAATATTTATTCGAAAACCATGGTCAAGTTGACGAAACATTTATCG
AAGACTTTTTTCTGACATATAATATGTACTTGACTTCCACAGTTCTGGTG
CGCAAAGCTATAATTGAACAGATCCCCCGAGTTTCGGAAAAACGGAAAAA
ATGCACCGACATTGTCGTGAAATGGATCAAAAATCACTTCAAAGAACTAG
AAAATCAATCAGAAATTATGAAATTTATCGATTTTTTATCGATGTTGCTC
TTTAGAGAAAATGAAGAGGAACATGCTGGAAAAATCTATCATACTTGTTC
AACTCATTCAACCCAAAGAAATGTAACAATAATGTCAAATGACAAAGATC
AAGGATCGCGCCCAGTTATCGTTGGTAATGGATCTCGAATTTCTTCCAAA
GACAAAGCGATAATGACAATTGAAAATTATCCTCGTGAATTTATGAGTTT
CAATTTATTTAGAAATGGTCAAAAATTGAACAATTTATTCATAAGTCAAA
TACGGAATTGTAGTGATTTACATGTCGGCGATCGAGTTATTCAGATTAAT
AATATATCGGAAGAAAACCTTACTCAAAAAGAAGCAAACACAATCCTATC
AAAGTCTCAGTTAACTATTTTGACTGTTAAATACGATCCTGAAGGATTTT
ATGCTCCTTTTCTTGTAAATTACCTGAAAAGAAAAAATCAAAGCCCAGTC
GATCGATCTTCACTCACGCACAGCGCTATGCTAGATTTTCCTGATTCTCC
AATAGAACCCGGATATTCCACCTTACCGCTGAAACCGAAATTGGGTGGGA
TCGGTCCACAGAATCAAGGAAAAATGAAAAAAATGCTGCCAAACAATGTC
AATCAAAGTGCAACCTCAAGTGCATTGAAGAAAATGATGAAACGATGCAA
AGCAAATAGCAGTTTCACGGATGAAAAAAAACAAAAATGCAAATCTAAAA
GCCGGAGTGCGCACAATTCTCCTGATCGGTTTCAAGTTTCCACTCCGGAT
TTAGCGTTCAATGAAAACCTTTCTGATTTGAAAATTAACTCAAATGTCAT
GTCGACAAGTTTCACTGAAACGAGCATTTCAAATATCAGAGCTGAAACTC
CAACTGTGAAAATGAGGAAAATAAGATCTCGATGTGGAAGTCAGCCAGAT
CTTCGGAAATCGGCCTTTTTCAACAGTGGAGAATTTTCCAGCTCTTCTTG
TGAATCAGTCATCAAAGTATATTACAAAGATCCCACAGATTCAATATCAA
TTGGGAAGTCAAACGTGAAATCAGTCTACCTCATAATCAGTAAAGAAACT
GAAGCATTGGAAGTCATTGTAAAAAGTCTGGTAGAATTAAATTTATCTTG
TGCCTCGAATTCTGAATTTTGCTTATGCGAAATTTCCGTTGAAACAGGAC
CGATTATAAAGCAGAAAATTATCAAGGAGAACACATCAAACTTAATGTCC
ATTGTAAAACTCAACAATCGATTCTTTATAAAACGACGAGATTTTTCCGG
AAAATTAATCGACAACGTCGACATTGAAGAGATCAATTCAGAAATGAATG
TGACGTTTTTCGATTTGCCAGTATGTGAATTGGCGACCCAGATCTTTGTT
GAAGGTTATAACGCATTTAAAAAGATATCTTTGTCCGAAATCATAGATTT
CGTTACGGGAAAATTGAGAAAGGAATCCTCAAACAACAAATCCAAACCCG
AACCGACACCTGGGCGACCTTTTGCAATTGGAACGAATTTGGATAACCGA
GATGGAAAAAGTGAAAGTGTCAATAATTTCCAAGAGTTTCTAAAATTGGG
TGAAAAATATATGTATTTCGTGGTGAATGTGGTATGTAGTGAAACGAATA
GTACTTCGAAACGCGGAAAAATTTTAAAAAGACTAATAAGAATGGCCCGA
CTTTGTAAAGAGTTGGGAAACATTGAAGTTTTCTTTTCTTTGATGAATGG
CTTAGATAGAGTCGAAATAAGTCGTCTAAGAAACACATGGGATCGAGTTC
CGAATAAAGATTTGAAGATGTATCGACAAATGCAGCAATTACTCGATGTT
TCTGGAAACATGCGACTGTTGCGCAGTCTTCACAAATCATGCAAACCTCC
AGTCATTCCAATGGCAGCCTTAGTCACGAAAGATCTGACAACGATTAATG
AAGTTCACCCTACAAAGGTTGAGGATGATGGACCAGAAAACGATCAGAAA
TCTGAAAATGAATATTTGATAAATTTTGATAAACTTCGGATAATGGCAAA
TCGAGCCAGATCATTTAAAAACCTCCTTTATGACTGTAGTATTAATAGTA
GTAAAGCAATAACATCAACAGAAAATCTTTTGCCTGAAAACGAGGGGGCA
CAAATTGCATTTATCAGAGAAATACTCTCAAAAATTGATCTCAAAGAAAG
TTCCAAAGGTTTATCAACCAGTCAAAATCATCTGAATCGTAGACGATCGG
CATGTATAAATACGAAAAAGATCTATGAAAACGAAATCAACCGTCTACGA
GTGAAATATTTCATCGGTAAAATTGAACAGATGGAACGTGACGATGCAAT
ACTGCTAGCAATGTCATATAAATGTGAACCCCGTTCAGAAATCACCGGTC
TCACTCCTAATGTTTCTCGGGCAACAATGGCAGGGATTTTGACATCACCT
ACAGGAAATTATGACAGAGAAGAAATCTTGAGTATTCGAAATTCAACCGG
TGGATCCATTTCATCAAAGGAATCTAGTCAAACAAACTATTCGAGTGGAT
CTGAACAACTTTCTGAATTGAGTGGTCAAAACAATTATCGAATCAATCAG
AAATACAGTAGAATCAATGCCAGCACTCCTTTATCTGGTCAGCTGCAATA
TCTAGAACCGTCGTCAGGATCTCAAAGAAGACATATTTTACCCCCGCCAT
ATTCATCTATTGGAACGATTCCACCAATTCCTCCTCGTCGTAAGTCGTCA
GTAGTTTCTGGAGAAAAAAACAGATCATTTTCCAATCCTTTATCAAATGG
TAAATCAATTTTTGCATGTTGCATTTTTCAAGTTAAATTTACAAAAAAAA
AACAAAAATAAAAATAAAGTTTTAATAAAATATATTTTTGCAATATTTAT
TTTATGGACTTGGCTGACAATATCATCAGGAGCTTAACAGAGTCCATTAG
TAATTGGATAATTATATGTGAGGAATTCAATAATCGCATGAATCACATGT
GCATTATATGAAGAGTGAATCTGTTAAACAATCTCAAAATAAAAGAATAT
CTTAAATTTCGGATTAATTAATTTCACAAGTGATGTGCTCCCAATAGTTT
TTATGCTTAACCTAGGCTGCCTGATTCTATTAAGAATTAATATGATACAT
ATTTAATTTATCCAATGTCAGAAGAATGAAGTATGTCATATATCACATAA
ACTTTATCATAATTTCTTTAGTTGTGAAGGACTGGCTACAATATGTGAAT
TTGAATAGAAATAGATTGAATATGGCATGACCATGTCCAACCCGTATCCT
TTAATGCTATTAAACACATATTGTACCAGTAGTATACATGACAAGTACCA
TTTGCCACGGTCATCTTAAAGTCTTAAGAAAATATTAACAATTAAATCCA
AAATTTAAAAAGAAACATATCAGAATTTTTAGGAGGAATTTATACCAGAA
TTTAATAAAATTTAATAACATAAATAATATTAAAATATAAATTTGTAGAC
GAAGTAGCGACACATCTCTGAGATATCCGATGTTGGTATCGTTTATGACA
ATACTGTGATAATATTTCAATTTTGCAGCTGCCTAATTTTATTCGAAATG
ACAAATTCGTTCAAATGAGATTTATATTTAATTTAATTATTTATATTACG
CAAATCCATTATAAATTTCTCAAAACAATTTATTCTATACAAATTTGTTC
TTTCCACTGGAATTTTGTTTAAATGAAGTACTCAACAGAGCACTAGTCAG
CATAGACCTCACAATTTTACTCAGTTTGATTGCAAAATATAATGGGATAT
TAGTGCCTACAAATAATTTATATCTGACCC

protein sequence of SMED30025424-orf-1

>SMED30025424-orf-1 ID=SMED30025424-orf-1|Name=SMED30025424-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1434bp
MSNISNSLICALEEDPKFRSKENIEIIVKYLMQISELEKCDNNDYTLCAH
IVQYKTFKRNNCIPRQSDSTIYWYHILYGSVLIGSAMFLPNNSFWIKDKS
NKETQYECIVLEDTGVLLFPYDNCNHSFYPCKCTKNTFSDSISKIKLNQK
SLNKSQTGSDTSSGYSGSDKISNGDSESINFKIDSNSSQQLRRKAASGSN
NLDTLTLDSDSEEDDLSDFTFNEISCQDHIKDILQKPSADRSTQENEVIM
NVIQNIPLFSLWTQSLRCAACKLARLQVVENTQTVLIKKDEKMTDWIYCL
QGTLEVRRTVENLNQNTDKNLSDVLETLRYSDSFGADLRKSEEQISKFYL
VSTSNDCWLMLINWKEFMKIKSQEPTTLTQIIENNKTVMIMERRCSADGS
TKGQVLVKATVRKLIEYLFENHGQVDETFIEDFFLTYNMYLTSTVLVRKA
IIEQIPRVSEKRKKCTDIVVKWIKNHFKELENQSEIMKFIDFLSMLLFRE
NEEEHAGKIYHTCSTHSTQRNVTIMSNDKDQGSRPVIVGNGSRISSKDKA
IMTIENYPREFMSFNLFRNGQKLNNLFISQIRNCSDLHVGDRVIQINNIS
EENLTQKEANTILSKSQLTILTVKYDPEGFYAPFLVNYLKRKNQSPVDRS
SLTHSAMLDFPDSPIEPGYSTLPLKPKLGGIGPQNQGKMKKMLPNNVNQS
ATSSALKKMMKRCKANSSFTDEKKQKCKSKSRSAHNSPDRFQVSTPDLAF
NENLSDLKINSNVMSTSFTETSISNIRAETPTVKMRKIRSRCGSQPDLRK
SAFFNSGEFSSSSCESVIKVYYKDPTDSISIGKSNVKSVYLIISKETEAL
EVIVKSLVELNLSCASNSEFCLCEISVETGPIIKQKIIKENTSNLMSIVK
LNNRFFIKRRDFSGKLIDNVDIEEINSEMNVTFFDLPVCELATQIFVEGY
NAFKKISLSEIIDFVTGKLRKESSNNKSKPEPTPGRPFAIGTNLDNRDGK
SESVNNFQEFLKLGEKYMYFVVNVVCSETNSTSKRGKILKRLIRMARLCK
ELGNIEVFFSLMNGLDRVEISRLRNTWDRVPNKDLKMYRQMQQLLDVSGN
MRLLRSLHKSCKPPVIPMAALVTKDLTTINEVHPTKVEDDGPENDQKSEN
EYLINFDKLRIMANRARSFKNLLYDCSINSSKAITSTENLLPENEGAQIA
FIREILSKIDLKESSKGLSTSQNHLNRRRSACINTKKIYENEINRLRVKY
FIGKIEQMERDDAILLAMSYKCEPRSEITGLTPNVSRATMAGILTSPTGN
YDREEILSIRNSTGGSISSKESSQTNYSSGSEQLSELSGQNNYRINQKYS
RINASTPLSGQLQYLEPSSGSQRRHILPPPYSSIGTIPPIPPRRKSSVVS
GEKNRSFSNPLSNGKSIFACCIFQVKFTKKKQK*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron
PLANA:0002056	medial muscle cell
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036964	RASGEF_cat_dom_sf
IPR036034	PDZ_sf
IPR008937	Ras-like_GEF
IPR001895	RASGEF_cat_dom
IPR000651	Ras-like_Gua-exchang_fac_N
IPR001478	PDZ
IPR014710	RmlC-like_jellyroll
IPR000159	RA_dom
IPR023578	Ras_GEF_dom_sf
IPR018490	cNMP-bd-like

Vocabulary: **molecular function**
Term	Definition
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005096	GTPase activator activity
GO:0017034	Rap guanyl-nucleotide exchange factor activity

Vocabulary: **biological process**
Term	Definition
GO:0007264	small GTPase mediated signal transduction
GO:0007165	signal transduction
GO:0042127	regulation of cell proliferation
GO:0043547	positive regulation of GTPase activity

Vocabulary: **cellular component**
Term	Definition
GO:0005622	intracellular

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal	SMART	SM00229	rasgefn_5	coord: 402..514 e-value: 0.0091 score: 19.4
IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal	PFAM	PF00618	RasGEF_N	coord: 408..490 e-value: 5.1E-7 score: 29.9
IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal	PROSITE	PS50212	RASGEF_NTER	coord: 402..517 score: 14.967
IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal	CDD	cd06224	REM	coord: 410..496 e-value: 4.6135E-10 score: 56.652
IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	SMART	SM00147	RasGEF_3	coord: 933..1276 e-value: 4.7E-19 score: 79.3
IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	PFAM	PF00617	RasGEF	coord: 940..1160 e-value: 2.8E-29 score: 102.6
IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	PROSITE	PS50009	RASGEF_CAT	coord: 937..1206 score: 34.701
IPR036964	Ras guanine-nucleotide exchange factor catalytic domain superfamily	GENE3D	G3DSA:1.10.840.10		coord: 926..1228 e-value: 1.8E-41 score: 144.1
IPR014710	RmlC-like jelly roll fold	GENE3D	G3DSA:2.60.120.10		coord: 7..115 e-value: 3.5E-7 score: 31.8
IPR014710	RmlC-like jelly roll fold	GENE3D	G3DSA:2.60.120.10		coord: 207..393 e-value: 2.5E-16 score: 61.5
None	No IPR available	GENE3D	G3DSA:1.20.870.10		coord: 394..520 e-value: 6.3E-10 score: 41.1
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1379..1403
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1312..1337
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 714..735
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 714..739
None	No IPR available	PANTHER	PTHR23113:SF249	DIZZY ISOFORM AII	coord: 135..1307
None	No IPR available	CDD	cd01785	RA_PDZ-GEF1	coord: 816..908 e-value: 1.35967E-15 score: 71.1869
None	No IPR available	TMHMM	TMhelix		coord: 70..89
IPR036034	PDZ superfamily	GENE3D	G3DSA:2.30.42.10		coord: 565..631 e-value: 3.0E-5 score: 26.0
IPR036034	PDZ superfamily	SUPERFAMILY	SSF50156	PDZ domain-like	coord: 574..630
IPR008937	Ras-like guanine nucleotide exchange factor	PANTHER	PTHR23113	GUANINE NUCLEOTIDE EXCHANGE FACTOR	coord: 135..1307
IPR000159	Ras-associating (RA) domain	PROSITE	PS50200	RA	coord: 814..912 score: 11.522
IPR018490	Cyclic nucleotide-binding-like	SUPERFAMILY	SSF51206	cAMP-binding domain-like	coord: 225..383
IPR018490	Cyclic nucleotide-binding-like	SUPERFAMILY	SSF51206	cAMP-binding domain-like	coord: 16..122
IPR023578	Ras guanine nucleotide exchange factor domain superfamily	SUPERFAMILY	SSF48366	Ras GEF	coord: 400..1276