GrpE protein homolog

Overview
NameGrpE protein homolog
Smed IDSMED30025422
Length (bp)779
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of GrpE protein homolog (SMED30025422) t-SNE clustered cells

Violin plots show distribution of expression levels for GrpE protein homolog (SMED30025422) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of GrpE protein homolog (SMED30025422) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for GrpE protein homolog (SMED30025422) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30025422

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30025422h1SMcG0012286 dd_Smed_v4_1172_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30025422h1SMcG0012286 dd_Smed_v4_1172_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30025422h1SMcG0012286 dd_Smed_v4_1172_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30025422h1SMcG0012286 dd_Smed_v4_1172_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30025422h1SMcG0012286 dd_Smed_v4_1172_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30025422h1SMcG0012286 Contig42201uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30025422h1SMcG0012286 Contig42201newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of GrpE protein homolog vs. Ensembl Human
Match: GRPEL1 (GrpE like 1, mitochondrial [Source:HGNC Symbol;Acc:HGNC:19696])

HSP 1 Score: 169.474 bits (428), Expect = 8.566e-52
Identity = 97/197 (49.24%), Postives = 129/197 (65.48%), Query Frame = 2 
Query:   50 RKVTAYTLRKNPYFYLISNRLYCDQLPDLDDTVKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEEL-EESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            R +   T +KN    L  +    +Q  D   T K L +E  KL +  KET +KYKRALA+ EN+RQR  + VEEAK +GI  FCKDLLEVADVL  ATQ V  EE+ +++ +LK +Y+G+ MTE Q+ KVF +HG+ ++ P +G KFDP  HEA+F  P     V+ +  GTVA+ SKVGYKL+ +TLRPA VGV +
Sbjct:   25 RLLCTATKQKNSGQNLEEDMGQSEQKADPPATEKTLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEEIKDDNPHLKNLYEGLVMTEVQIQKVFTKHGLLKLNP-VGAKFDPYEHEALFHTP-----VEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
[Close]
BLAST of GrpE protein homolog vs. Ensembl Human
Match: GRPEL2 (GrpE like 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:21060])

HSP 1 Score: 121.709 bits (304), Expect = 4.283e-33
Identity = 67/163 (41.10%), Postives = 106/163 (65.03%), Query Frame = 2 
Query:  149 KQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQ--YLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGV 631
            + LR +  KL    ++   +Y+RA+A+CEN+R+R  R VE+AK FGI  FCKDL+EVAD+L   T+ +  E   E Q   L++++ G+ + E+++  VFA+HG+E++ P IG+K+DP+ HE +  +P     V  +  GTVA+  + GYKL+ +T+R A V V
Sbjct:   60 RALRVKAVKLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTECISEESEPEDQKLTLEKVFRGLLLLEAKLKSVFAKHGLEKLTP-IGDKYDPHEHELICHVPA---GVGVQ-PGTVALVRQDGYKLHGRTIRLARVEV 217
[Close]
BLAST of GrpE protein homolog vs. Ensembl Celegans
Match: C34C12.8 (GrpE protein homolog, mitochondrial [Source:UniProtKB/Swiss-Prot;Acc:Q18421])

HSP 1 Score: 148.288 bits (373), Expect = 1.205e-43
Identity = 73/145 (50.34%), Postives = 102/145 (70.34%), Query Frame = 2 
Query:  200 EDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEE-SQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGV 631
            +DKY+R+LAE ENVR+R  +Q ++AK F I  FCKDLLEV+D+L  A ++VK E+LE   + LK +++G+ MT + M K FA+HG+  + P   EKFDPN HEA+FQIP  + K   + VG + VC+K+GY L  + +RPA VGV
Sbjct:   94 KDKYQRSLAETENVRRRGIKQTDDAKVFAIQSFCKDLLEVSDILDIAVKSVKPEDLESGGKALKDLFEGVSMTRTVMAKTFAKHGLVTVDP-TNEKFDPNLHEAVFQIPSANAK---QPVGHIEVCTKIGYSLKERPIRPAQVGV 234
[Close]
BLAST of GrpE protein homolog vs. Ensembl Fly
Match: Roe1 (gene:FBgn0014877 transcript:FBtr0087675)

HSP 1 Score: 147.517 bits (371), Expect = 1.212e-43
Identity = 79/171 (46.20%), Postives = 114/171 (66.67%), Query Frame = 2 
Query:  128 PDLDDTVKQL---RDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGV 631
            P+++   K+L   +++NA+L D       KYKR+LA+ EN+R R+++Q+ +AK FGI  FCKDLLEVAD L  ATQAV  ++L  +  LK +Y+G+ MT + +L+VF RHG+E + P I +KFDPN HEA+FQ      + K     TV   +K+GYKL+ + +RPA VGV
Sbjct:   53 PEVEKLTKELAAAKEQNAELMD-------KYKRSLADSENMRNRLNKQISDAKIFGIQSFCKDLLEVADTLGHATQAVPKDKLSGNADLKNLYEGLTMTRASLLQVFKRHGLEPLDP-INQKFDPNQHEALFQ-----KEDKTVEPNTVVEVTKLGYKLHERCIRPALVGV 210
[Close]
BLAST of GrpE protein homolog vs. Ensembl Zebrafish
Match: grpel1 (GrpE-like 1, mitochondrial [Source:ZFIN;Acc:ZDB-GENE-051120-111])

HSP 1 Score: 156.377 bits (394), Expect = 6.746e-47
Identity = 81/164 (49.39%), Postives = 115/164 (70.12%), Query Frame = 2 
Query:  149 KQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAV-KTEELEESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            K   +E  +L +  K+  DKYKRALA+ EN+RQR  + +++AK +GI  FCKDLLEVAD+L  AT++V KTE    + +LK +YDG+ MTE Q+ KVF +HG+ ++ P+ G+KFDP  HEA+F  P     V+ +  GT+A+ +KVGYKL+ +TLRPA VGV +
Sbjct:   58 KAFLEEKTQLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEKATESVPKTEISAANPHLKNLYDGLVMTEVQIQKVFQKHGLVKLSPD-GQKFDPYEHEAVFHAP-----VEGKEPGTIALVTKVGYKLHGRTLRPALVGVVK 215
[Close]
BLAST of GrpE protein homolog vs. Ensembl Zebrafish
Match: grpel2 (GrpE-like 2, mitochondrial [Source:ZFIN;Acc:ZDB-GENE-091204-188])

HSP 1 Score: 98.2117 bits (243), Expect = 1.805e-24
Identity = 56/162 (34.57%), Postives = 93/162 (57.41%), Query Frame = 2 
Query:  146 VKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGV 631
            V+ L     KL +   +  ++YKRA+A+ +NVR+R  + VE+AK FGI  FC+DL+EVAD+L       K   +EES   +Q+   +   + ++  +F +HG+E++ P +G  +DP  HE +   P    +      GT+A+  + GY L+ +T+R A VG+
Sbjct:   61 VRTLEMRARKLEEQVHDLTERYKRAVADSDNVRRRTQKFVEDAKLFGIQSFCRDLVEVADLLE------KNLTVEESDGAQQLAQYLAHIQERLQDIFTKHGLEKMTP-VGTTYDPYQHEIVCHTPAEGAE-----PGTIAMVKQDGYMLHGRTIRHALVGI 210
[Close]
BLAST of GrpE protein homolog vs. Ensembl Xenopus
Match: grpel1 (GrpE-like 1, mitochondrial [Source:NCBI gene;Acc:548933])

HSP 1 Score: 161.384 bits (407), Expect = 1.229e-48
Identity = 85/168 (50.60%), Postives = 118/168 (70.24%), Query Frame = 2 
Query:  137 DDTVKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELE-ESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            +++  Q   E AKL D  K+  DKYKRALA+ EN+RQR  + V+EAK +GI  FCKDLLEVAD+L  AT++V   E++ E+ +LK +Y+G+ MTE QM KV  +HGV ++ P +G+KF+P  HEA+F  P     V+ +  GTVA+ +KVGYKL+ +TLRPA VGV +
Sbjct:   53 EESPDQAATEKAKLEDQIKDLTDKYKRALADTENLRQRSKKLVDEAKLYGIQGFCKDLLEVADILEKATESVPKAEIKAENPHLKNLYEGLIMTEVQMQKVLKKHGVVKLNP-VGDKFNPYEHEALFHSP-----VEGKEPGTVALVTKVGYKLHERTLRPALVGVVK 214
[Close]
BLAST of GrpE protein homolog vs. Ensembl Xenopus
Match: grpel2 (GrpE like 2, mitochondrial [Source:NCBI gene;Acc:100216254])

HSP 1 Score: 102.064 bits (253), Expect = 1.059e-25
Identity = 58/163 (35.58%), Postives = 93/163 (57.06%), Query Frame = 2 
Query:  143 TVKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGV 631
             V+ L  +  KL +  ++  ++YKRA+A+ ENVR+R  + VE+AK FGI  FC+DL+EVAD +  A +    E + +   +    DG      ++  VF +HG++++ P  GE +DP  HE +  +P    K      G++A  S  GYKL+ +T+R A VG+
Sbjct:   74 AVRALERKALKLEEEVRDLSERYKRAIADSENVRKRTQKFVEDAKLFGIQSFCRDLVEVADTIEQAVEKATKEGIRDMAAVLSHLDG------KLQGVFIKHGLQKMTPLEGE-YDPYDHEIVCHVPADGKK-----PGSIATISLDGYKLHGRTIRHAQVGI 224
[Close]
BLAST of GrpE protein homolog vs. Ensembl Xenopus
Match: grpel2 (GrpE like 2, mitochondrial [Source:NCBI gene;Acc:100216254])

HSP 1 Score: 101.679 bits (252), Expect = 1.134e-25
Identity = 58/163 (35.58%), Postives = 93/163 (57.06%), Query Frame = 2 
Query:  143 TVKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGV 631
             V+ L  +  KL +  ++  ++YKRA+A+ ENVR+R  + VE+AK FGI  FC+DL+EVAD +  A +    E + +   +    DG      ++  VF +HG++++ P  GE +DP  HE +  +P    K      G++A  S  GYKL+ +T+R A VG+
Sbjct:   64 AVRALERKALKLEEEVRDLSERYKRAIADSENVRKRTQKFVEDAKLFGIQSFCRDLVEVADTIEQAVEKATKEGIRDMAAVLSHLDG------KLQGVFIKHGLQKMTPLEGE-YDPYDHEIVCHVPADGKK-----PGSIATISLDGYKLHGRTIRHAQVGI 214
[Close]
BLAST of GrpE protein homolog vs. Ensembl Mouse
Match: Grpel1 (GrpE-like 1, mitochondrial [Source:MGI Symbol;Acc:MGI:1334417])

HSP 1 Score: 171.785 bits (434), Expect = 7.853e-53
Identity = 97/197 (49.24%), Postives = 129/197 (65.48%), Query Frame = 2 
Query:   50 RKVTAYTLRKNPYFYLISNRLYCDQLPDLDDTVKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQ-YLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            R +   T +KN    L  +  +C+   D     K L +E AKL +  +ET +KYKRALA+ EN+RQR  + VEEAK +GI  FCKDLLEVAD+L  ATQ+V  EE+  +  +LK +Y+G+ MTE Q+ KVF +HG+ R+ P IG KFDP  HEA+F  P     V+ +  GTVA+ SKVGYKL+ +TLRPA VGV +
Sbjct:   25 RLLCTATKQKNNGQNLDEDLGHCEPKTDPPSADKTLLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEISNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDP-IGAKFDPYEHEALFHTP-----VEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
[Close]
BLAST of GrpE protein homolog vs. Ensembl Mouse
Match: Grpel2 (GrpE-like 2, mitochondrial [Source:MGI Symbol;Acc:MGI:1334416])

HSP 1 Score: 113.235 bits (282), Expect = 5.062e-30
Identity = 64/158 (40.51%), Postives = 102/158 (64.56%), Query Frame = 2 
Query:  173 KLTDIFKETED---KYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVL--TTATQAVKTEELEESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGV 631
            K   + KE +D   +Y+RA+A+CEN+R+R  R VE+AK FGI  FCKDL+EVAD+L  T    +   E  +  + L++++ G+ + E+++  VF +HG+E++ P IG+K+DP+ HE +  +P     V  +  GTVA+  + GYKL+ +T+R A V V
Sbjct:   64 KAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKCCSEGAEPEDHRRTLEKVFQGLSLLEARLKSVFTKHGLEKMTP-IGDKYDPHEHELICHMPA---GVGVQ-PGTVALVRQDGYKLHGRTIRLAQVEV 216
[Close]
BLAST of GrpE protein homolog vs. UniProt/SwissProt
Match: sp|Q99LP6|GRPE1_MOUSE (GrpE protein homolog 1, mitochondrial OS=Mus musculus OX=10090 GN=Grpel1 PE=1 SV=1)

HSP 1 Score: 171.785 bits (434), Expect = 5.493e-52
Identity = 97/197 (49.24%), Postives = 129/197 (65.48%), Query Frame = 2 
Query:   50 RKVTAYTLRKNPYFYLISNRLYCDQLPDLDDTVKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQ-YLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            R +   T +KN    L  +  +C+   D     K L +E AKL +  +ET +KYKRALA+ EN+RQR  + VEEAK +GI  FCKDLLEVAD+L  ATQ+V  EE+  +  +LK +Y+G+ MTE Q+ KVF +HG+ R+ P IG KFDP  HEA+F  P     V+ +  GTVA+ SKVGYKL+ +TLRPA VGV +
Sbjct:   25 RLLCTATKQKNNGQNLDEDLGHCEPKTDPPSADKTLLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEISNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDP-IGAKFDPYEHEALFHTP-----VEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
[Close]
BLAST of GrpE protein homolog vs. UniProt/SwissProt
Match: sp|P97576|GRPE1_RAT (GrpE protein homolog 1, mitochondrial OS=Rattus norvegicus OX=10116 GN=Grpel1 PE=1 SV=2)

HSP 1 Score: 171.014 bits (432), Expect = 9.237e-52
Identity = 97/197 (49.24%), Postives = 128/197 (64.97%), Query Frame = 2 
Query:   50 RKVTAYTLRKNPYFYLISNRLYCDQLPDLDDTVKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQ-YLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            R +   T +KN    L  +  +C+   D     K L +E  KL +  KET +KYKRALA+ EN+RQR  + VEEAK +GI  FCKDLLEVAD+L  ATQ+V  EE+  +  +LK +Y+G+ MTE Q+ KVF +HG+ R+ P IG KFDP  HEA+F  P     V+ +  GTVA+ SKVGYKL+ +TLRPA VGV +
Sbjct:   25 RLLCTATKQKNNGQNLEEDLGHCEPKTDPSSADKTLLEEKVKLEEQLKETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEVSNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDP-IGAKFDPYEHEALFHTP-----VEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
[Close]
BLAST of GrpE protein homolog vs. UniProt/SwissProt
Match: sp|Q3SZC1|GRPE1_BOVIN (GrpE protein homolog 1, mitochondrial OS=Bos taurus OX=9913 GN=GRPEL1 PE=1 SV=1)

HSP 1 Score: 171.014 bits (432), Expect = 1.251e-51
Identity = 92/174 (52.87%), Postives = 122/174 (70.11%), Query Frame = 2 
Query:  119 DQLPDLDDTVKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEEL-EESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            +Q  DL  T K L +E  KL +  KET +KYKRALA+ EN+RQR  + VEEAK +GI  FCKDLLEVAD+L  ATQ V  EE+ +++ +LK +Y+G+ MTE Q+ KVF +HG+ R+ P +G KFDP  HEA+F  P     V+ +  GTVA+ +KVGYKL+ +TLRPA VGV +
Sbjct:   48 EQKTDLPSTEKTLMEEKVKLEEQLKETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQCVPQEEIRDDNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLNP-LGAKFDPYEHEALFHTP-----VEGKEPGTVALVNKVGYKLHGRTLRPALVGVVK 215
[Close]
BLAST of GrpE protein homolog vs. UniProt/SwissProt
Match: sp|Q5RA81|GRPE1_PONAB (GrpE protein homolog 1, mitochondrial OS=Pongo abelii OX=9601 GN=GRPEL1 PE=2 SV=1)

HSP 1 Score: 169.474 bits (428), Expect = 4.114e-51
Identity = 97/197 (49.24%), Postives = 129/197 (65.48%), Query Frame = 2 
Query:   50 RKVTAYTLRKNPYFYLISNRLYCDQLPDLDDTVKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEEL-EESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            R +   T +KN    L  +    +Q  D   T K L +E  KL +  KET +KYKRALA+ EN+RQR  + VEEAK +GI  FCKDLLEVADVL  ATQ V  EE+ +++ +LK +Y+G+ MTE Q+ KVF +HG+ ++ P +G KFDP  HEA+F  P     V+ +  GTVA+ SKVGYKL+ +TLRPA VGV +
Sbjct:   25 RLLCTATKQKNSGQNLEEDMGQSEQKADPPATEKTLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEEIKDDNPHLKNLYEGLVMTEVQIQKVFTKHGLLKLNP-VGAKFDPYEHEALFHTP-----VEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
[Close]
BLAST of GrpE protein homolog vs. UniProt/SwissProt
Match: sp|Q9HAV7|GRPE1_HUMAN (GrpE protein homolog 1, mitochondrial OS=Homo sapiens OX=9606 GN=GRPEL1 PE=1 SV=2)

HSP 1 Score: 169.474 bits (428), Expect = 4.114e-51
Identity = 97/197 (49.24%), Postives = 129/197 (65.48%), Query Frame = 2 
Query:   50 RKVTAYTLRKNPYFYLISNRLYCDQLPDLDDTVKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEEL-EESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            R +   T +KN    L  +    +Q  D   T K L +E  KL +  KET +KYKRALA+ EN+RQR  + VEEAK +GI  FCKDLLEVADVL  ATQ V  EE+ +++ +LK +Y+G+ MTE Q+ KVF +HG+ ++ P +G KFDP  HEA+F  P     V+ +  GTVA+ SKVGYKL+ +TLRPA VGV +
Sbjct:   25 RLLCTATKQKNSGQNLEEDMGQSEQKADPPATEKTLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEEIKDDNPHLKNLYEGLVMTEVQIQKVFTKHGLLKLNP-VGAKFDPYEHEALFHTP-----VEGKEPGTVALVSKVGYKLHGRTLRPALVGVVK 215
[Close]
BLAST of GrpE protein homolog vs. TrEMBL
Match: A0A0B6ZL25 (Uncharacterized protein OS=Arion vulgaris OX=1028688 GN=ORF66674 PE=3 SV=1)

HSP 1 Score: 188.348 bits (477), Expect = 6.831e-56
Identity = 91/175 (52.00%), Postives = 127/175 (72.57%), Query Frame = 2 
Query:  128 PDLDDTVKQLRD----ENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQ-YLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            P   D+V Q RD    +  KL +  KE++DKY RALAE EN+R+RM +QV+EAK FGI  FCKDLL+V+D+L+TA  +V  E L  S  +L  ++ G+ MT+SQ++KVF +HG+E I P +G+KFDPN+HEA+FQ+P+ S+K +     TVA+  K+GYKL+ +TLRPA VGVF+
Sbjct:   52 PQEKDSVVQERDKLTSQVQKLEEDLKESKDKYLRALAETENLRKRMIKQVDEAKIFGIQSFCKDLLDVSDILSTAINSVPKENLNNSNPHLVNLFQGLNMTDSQLVKVFNKHGLESISPTLGDKFDPNYHEALFQVPIQSEKTQVP--DTVAIVQKIGYKLHSRTLRPALVGVFK 224
[Close]
BLAST of GrpE protein homolog vs. TrEMBL
Match: T1IYX4 (GrpE protein homolog OS=Strigamia maritima OX=126957 PE=3 SV=1)

HSP 1 Score: 187.578 bits (475), Expect = 1.050e-55
Identity = 94/165 (56.97%), Postives = 126/165 (76.36%), Query Frame = 2 
Query:  146 VKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEEL-EESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            +++L  +N +L +  ++T+DKYKRALAE ENVRQRM RQ++EAK FGI  FCKDLLEVADVL  AT++V + EL   +Q+LK +YDG++MTESQ+ KVF  +G+ +I P IGEKFDPN HEA+F+     DK + +  GTVAV SKVGY L+++T+RPA VGV +
Sbjct:   62 IQELEVKNKELFEKLEDTQDKYKRALAETENVRQRMRRQIDEAKMFGIQAFCKDLLEVADVLAKATESVPSTELNNNNQHLKTLYDGLRMTESQLQKVFRLYGLNQINP-IGEKFDPNLHEALFE-----DKFEGKDPGTVAVVSKVGYTLHNRTIRPAAVGVVK 220
[Close]
BLAST of GrpE protein homolog vs. TrEMBL
Match: A0A210PV47 (GrpE protein homolog OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT25117 PE=3 SV=1)

HSP 1 Score: 185.267 bits (469), Expect = 1.138e-54
Identity = 92/162 (56.79%), Postives = 120/162 (74.07%), Query Frame = 2 
Query:  155 LRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEEL-EESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            L+ E AKL +  K+ +DKY RALAE ENVR+RM  QV++AK FGI  FCKDLLEVAD+L  AT++V  EEL EE+ +LK ++ G+ MTESQ+LKVF +HG+E+I P  GEKFDP  HEAMF++P P    +A    T+AV +K GYKL  +T+RPA VGV++
Sbjct:   65 LQKEKAKLEETMKDIKDKYMRALAETENVRRRMKNQVDDAKIFGIQGFCKDLLEVADILGKATESVPKEELKEENIHLKNLFQGLTMTESQLLKVFNKHGLEQIAPSEGEKFDPFVHEAMFEVPTPDKDAEA----TIAVITKKGYKLQSRTIRPALVGVYK 222
[Close]
BLAST of GrpE protein homolog vs. TrEMBL
Match: R7UPJ0 (GrpE protein homolog (Fragment) OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_165833 PE=3 SV=1)

HSP 1 Score: 184.496 bits (467), Expect = 1.995e-54
Identity = 88/170 (51.76%), Postives = 123/170 (72.35%), Query Frame = 2 
Query:  131 DLDDTVKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQ-YLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            D ++ VK L +E  KL +  ++ +DKYKR+LAE ENVR RM +Q+ +AK FGI  FCKDLLEVAD+L+ A ++V  +E+     +LK +++G+ MTE+Q+ KVF R+G+E I P  G KFDPN HEA+F+ PVP  +      GTVAV +KVGYKL+++T+RPA VGVF+
Sbjct:   54 DTNEAVKALEEEKTKLMEKLEDVQDKYKRSLAETENVRNRMQKQINDAKLFGIQGFCKDLLEVADILSKANESVPKDEVTNGNPHLKNLFEGLTMTETQLTKVFTRNGLEMINPAEGVKFDPNIHEALFEQPVPDKE-----PGTVAVVTKVGYKLHNRTIRPALVGVFK 218
[Close]
BLAST of GrpE protein homolog vs. TrEMBL
Match: A0A433T589 (Uncharacterized protein OS=Elysia chlorotica OX=188477 GN=EGW08_015528 PE=3 SV=1)

HSP 1 Score: 182.956 bits (463), Expect = 1.054e-53
Identity = 86/156 (55.13%), Postives = 117/156 (75.00%), Query Frame = 2 
Query:  173 KLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQ-YLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            KL +  K ++DKY R+LAE EN+R RM +Q+E+AK FGI  FCKDLLEV+D+L TA  +V  EEL +S  +L  +Y G+ MTESQ++KVF +HG+E I+P  GEKFDP+FHEA+FQ+P+ S + +     TVAV  K+G+KL+ +TLRPA VGVF+
Sbjct:   78 KLQEDLKSSKDKYVRSLAEAENIRTRMGKQIEDAKLFGIQGFCKDLLEVSDILGTAVSSVPKEELTDSNPHLVNLYQGLNMTESQLIKVFKKHGLESIKPSEGEKFDPHFHEALFQVPIQSTETQE--ADTVAVVQKIGFKLHKRTLRPALVGVFK 231
[Close]
BLAST of GrpE protein homolog vs. Ensembl Cavefish
Match: grpel1 (GrpE-like 1, mitochondrial [Source:ZFIN;Acc:ZDB-GENE-051120-111])

HSP 1 Score: 162.925 bits (411), Expect = 8.890e-50
Identity = 84/174 (48.28%), Postives = 120/174 (68.97%), Query Frame = 2 
Query:  119 DQLPDLDDTVKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQ-YLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
             Q P+     K L +E  +L +  K+  DKYKRALA+ EN+RQR  + ++EAK +GI  FCKDLLEVAD+L  AT++V  EE+  +  +LK +YDG+ MTE Q+ KVF++HG+ ++ P +G+KFDP  HEA+F  P     V+ +  GTVA+ +KVGYK++ +TLRPA VGV +
Sbjct:   30 SQKPEPSPAEKALTEEKIQLEEQVKDLTDKYKRALADTENIRQRSQKMIDEAKLYGIQGFCKDLLEVADILEKATESVPKEEVTSANPHLKNLYDGLVMTEVQIQKVFSKHGLVKLDP-VGQKFDPYEHEALFHAP-----VEGKEPGTVALVTKVGYKIHGRTLRPALVGVVK 197
[Close]
BLAST of GrpE protein homolog vs. Ensembl Cavefish
Match: grpel1 (GrpE-like 1, mitochondrial [Source:ZFIN;Acc:ZDB-GENE-051120-111])

HSP 1 Score: 149.828 bits (377), Expect = 2.215e-44
Identity = 80/173 (46.24%), Postives = 116/173 (67.05%), Query Frame = 2 
Query:  122 QLPDLDDTVKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQ-YLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            Q P+     K L +E  +L +  K+      RALA+ EN+RQR  + ++EAK +GI  FCKDLLEVAD+L  AT++V  EE+  +  +LK +YDG+ MTE Q+ KVF++HG+ ++ P +G+KFDP  HEA+F  P     V+ +  GTVA+ +KVGYK++ +TLRPA VGV +
Sbjct:   48 QKPEPSPAEKALTEEKIQLEEQVKD----LTRALADTENIRQRSQKMIDEAKLYGIQGFCKDLLEVADILEKATESVPKEEVTSANPHLKNLYDGLVMTEVQIQKVFSKHGLVKLDP-VGQKFDPYEHEALFHAP-----VEGKEPGTVALVTKVGYKIHGRTLRPALVGVVK 210
[Close]
BLAST of GrpE protein homolog vs. Ensembl Cavefish
Match: grpel2 (grpE protein homolog 2, mitochondrial [Source:NCBI gene;Acc:103032477])

HSP 1 Score: 103.219 bits (256), Expect = 1.925e-26
Identity = 60/164 (36.59%), Postives = 97/164 (59.15%), Query Frame = 2 
Query:  146 VKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFV--GTVAVCSKVGYKLYHKTLRPATVGV 631
            V+ L  +  KL +  ++  ++YKRA+A+ +NVR+R  + VE+AK FGI  FC+DL+EVAD+L   T + +T  L E+         +   + ++ +VF +HG+E++ P +G  +DP  HE +   P       AE V  G +AV  + GYKL+ +T+R A VG+
Sbjct:   61 VRNLEMKADKLEEQVQDLTERYKRAVADSDNVRRRTQKFVEDAKLFGIQSFCRDLVEVADMLEKTTGSTETTSLTEN---------LAQIQGRLQEVFTKHGLEKMEP-VGSTYDPYQHEIVCHTP-------AEGVEPGIIAVVKQDGYKLHGRTIRHAHVGI 207
[Close]
BLAST of GrpE protein homolog vs. Ensembl Sea Lamprey
Match: grpel1 (GrpE-like 1, mitochondrial [Source:ZFIN;Acc:ZDB-GENE-051120-111])

HSP 1 Score: 155.221 bits (391), Expect = 4.696e-47
Identity = 78/160 (48.75%), Postives = 112/160 (70.00%), Query Frame = 2 
Query:  161 DENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQ-YLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            +E  KL +  K+  D+YKRALA+ ENVR+R  + +E+ K FGI  FCKDLLEVAD+L  AT++V  EEL ++  +LK +Y+G+ +TESQ+ KVF +HG+  + P I  KFDP  HEA+FQ+P     ++ +  GTV V +K+GYKL+ + +RPA VGV +
Sbjct:   75 EEKTKLEEQVKDLTDRYKRALADTENVRRRSQKMIEDGKIFGIQSFCKDLLEVADILQKATESVPKEELNDANPHLKSLYEGLILTESQLQKVFTKHGLVPLNP-IDAKFDPYEHEALFQVP-----MEGKNPGTVGVVTKIGYKLHTRIVRPAIVGVVK 228
[Close]
BLAST of GrpE protein homolog vs. Ensembl Yeast
Match: MGE1 (Mitochondrial matrix cochaperone; nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; acts as oxidative sensor to regulate mitochondrial Ssc1p; in presence of oxidative stress, dimeric Mge1p becomes a monomer and unable to regulate Ssc1p function; homolog of E. coli GrpE and human Mge1 (GRPEL1), which also responds to oxidative stress [Source:SGD;Acc:S000005758])

HSP 1 Score: 107.842 bits (268), Expect = 4.749e-29
Identity = 56/162 (34.57%), Postives = 94/162 (58.02%), Query Frame = 2 
Query:  146 VKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGV 631
            +K+L  + +  T    E +D+  R++A+  N++Q   + +++AK F + KF KDLLE  D    A  A K E+L++S+ +  +Y G++MT         +HG+E++ P +GE FDPN HEA F++P P  +      GTV    ++G+ L  + +RPA VG+
Sbjct:   67 IKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVDNFGHALNAFKEEDLQKSKEISDLYTGVRMTRDVFENTLRKHGIEKLDP-LGEPFDPNKHEATFELPQPDKE-----PGTVFHVQQLGFTLNDRVIRPAKVGI 222
[Close]
BLAST of GrpE protein homolog vs. Ensembl Nematostella
Match: EDO47213 (GrpE protein homolog [Source:UniProtKB/TrEMBL;Acc:A7RMW1])

HSP 1 Score: 155.606 bits (392), Expect = 6.424e-47
Identity = 80/151 (52.98%), Postives = 108/151 (71.52%), Query Frame = 2 
Query:  185 IFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            +  E EDKYKR+LAE +NV QR  + VEEA+ F I  F KDLLE+AD+L  AT +V  EEL+++ +LK +++G+ MTE+Q+ KVF ++G+E++ PE GEKF+P+FHEA+FQ   P DK      GTVAV  K+GY L   TLRPA VGV +
Sbjct:   87 LVTELEDKYKRSLAENQNVLQRSQKMVEEARLFAIRGFSKDLLEIADILEKATTSVPKEELDKNSHLKNLFEGLTMTEAQLHKVFNKNGLEKMNPE-GEKFNPHFHEAVFQFDAP-DKED----GTVAVVQKIGYTLNGITLRPALVGVVK 231
[Close]
BLAST of GrpE protein homolog vs. Ensembl Medaka
Match: grpel1 (GrpE like 1, mitochondrial [Source:NCBI gene;Acc:101155803])

HSP 1 Score: 159.073 bits (401), Expect = 1.781e-47
Identity = 93/216 (43.06%), Postives = 134/216 (62.04%), Query Frame = 2 
Query:   29 SIMISGIRKVTAYTLRKNPYFYLISNRLYC-------DQLPDLDD-------TVKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEEL-EESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGV 631
            S  +  +R+  +Y L  +P F     RL C        Q P+ +          K   +E  +L +  KE  +KYKR+LA+ EN+R+R  + VE+AK +GI  FCKDLLEVAD+L  AT++V  EE+  ++ +LK +YDG+ MTE Q+ KVF++HG+ ++ PE G+KFDP  HEA+F  P     ++ +  GTVAV +KVGYKL+ +TLRPA VGV
Sbjct:   48 SWCVRAVRQ--SYCLVASPTFVRAPPRLLCTAAQRKNGQGPEEEAEKAEQSAPEKTPAEEKTQLEEQLKEMTEKYKRSLADAENLRRRSQKMVEDAKLYGIQGFCKDLLEVADILEKATESVPKEEVTSQNPHLKNLYDGLLMTEVQIQKVFSKHGLVKLNPE-GQKFDPYEHEALFHAP-----MEGKEPGTVAVVTKVGYKLHGRTLRPALVGV 255
[Close]
BLAST of GrpE protein homolog vs. Planmine SMEST
Match: SMESG000004230.1 (SMESG000004230.1)

HSP 1 Score: 419.083 bits (1076), Expect = 8.919e-151
Identity = 201/201 (100.00%), Postives = 201/201 (100.00%), Query Frame = 2 
Query:   35 MISGIRKVTAYTLRKNPYFYLISNRLYCDQLPDLDDTVKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 637
            MISGIRKVTAYTLRKNPYFYLISNRLYCDQLPDLDDTVKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ
Sbjct:    1 MISGIRKVTAYTLRKNPYFYLISNRLYCDQLPDLDDTVKQLRDENAKLTDIFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLTTATQAVKTEELEESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEKFDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVFQ 201
The following BLAST results are available for this feature:
BLAST of GrpE protein homolog vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
GRPEL18.566e-5249.24GrpE like 1, mitochondrial [Source:HGNC Symbol;Acc... [more]
GRPEL24.283e-3341.10GrpE like 2, mitochondrial [Source:HGNC Symbol;Acc... [more]
back to top
BLAST of GrpE protein homolog vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
C34C12.81.205e-4350.34GrpE protein homolog, mitochondrial [Source:UniPr... [more]
back to top
BLAST of GrpE protein homolog vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Roe11.212e-4346.20gene:FBgn0014877 transcript:FBtr0087675[more]
back to top
BLAST of GrpE protein homolog vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
grpel16.746e-4749.39GrpE-like 1, mitochondrial [Source:ZFIN;Acc:ZDB-GE... [more]
grpel21.805e-2434.57GrpE-like 2, mitochondrial [Source:ZFIN;Acc:ZDB-GE... [more]
back to top
BLAST of GrpE protein homolog vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3
Match NameE-valueIdentityDescription
grpel11.229e-4850.60GrpE-like 1, mitochondrial [Source:NCBI gene;Acc:5... [more]
grpel21.059e-2535.58GrpE like 2, mitochondrial [Source:NCBI gene;Acc:1... [more]
grpel21.134e-2535.58GrpE like 2, mitochondrial [Source:NCBI gene;Acc:1... [more]
back to top
BLAST of GrpE protein homolog vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Grpel17.853e-5349.24GrpE-like 1, mitochondrial [Source:MGI Symbol;Acc:... [more]
Grpel25.062e-3040.51GrpE-like 2, mitochondrial [Source:MGI Symbol;Acc:... [more]
back to top
BLAST of GrpE protein homolog vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q99LP6|GRPE1_MOUSE5.493e-5249.24GrpE protein homolog 1, mitochondrial OS=Mus muscu... [more]
sp|P97576|GRPE1_RAT9.237e-5249.24GrpE protein homolog 1, mitochondrial OS=Rattus no... [more]
sp|Q3SZC1|GRPE1_BOVIN1.251e-5152.87GrpE protein homolog 1, mitochondrial OS=Bos tauru... [more]
sp|Q5RA81|GRPE1_PONAB4.114e-5149.24GrpE protein homolog 1, mitochondrial OS=Pongo abe... [more]
sp|Q9HAV7|GRPE1_HUMAN4.114e-5149.24GrpE protein homolog 1, mitochondrial OS=Homo sapi... [more]
back to top
BLAST of GrpE protein homolog vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0B6ZL256.831e-5652.00Uncharacterized protein OS=Arion vulgaris OX=10286... [more]
T1IYX41.050e-5556.97GrpE protein homolog OS=Strigamia maritima OX=1269... [more]
A0A210PV471.138e-5456.79GrpE protein homolog OS=Mizuhopecten yessoensis OX... [more]
R7UPJ01.995e-5451.76GrpE protein homolog (Fragment) OS=Capitella telet... [more]
A0A433T5891.054e-5355.13Uncharacterized protein OS=Elysia chlorotica OX=18... [more]
back to top
BLAST of GrpE protein homolog vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
grpel18.890e-5048.28GrpE-like 1, mitochondrial [Source:ZFIN;Acc:ZDB-GE... [more]
grpel12.215e-4446.24GrpE-like 1, mitochondrial [Source:ZFIN;Acc:ZDB-GE... [more]
grpel21.925e-2636.59grpE protein homolog 2, mitochondrial [Source:NCBI... [more]
back to top
BLAST of GrpE protein homolog vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
grpel14.696e-4748.75GrpE-like 1, mitochondrial [Source:ZFIN;Acc:ZDB-GE... [more]
back to top
BLAST of GrpE protein homolog vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
MGE14.749e-2934.57Mitochondrial matrix cochaperone; nucleotide relea... [more]
back to top
BLAST of GrpE protein homolog vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO472136.424e-4752.98GrpE protein homolog [Source:UniProtKB/TrEMBL;Acc... [more]
back to top
BLAST of GrpE protein homolog vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
grpel11.781e-4743.06GrpE like 1, mitochondrial [Source:NCBI gene;Acc:1... [more]
back to top
BLAST of GrpE protein homolog vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000004230.18.919e-151100.00SMESG000004230.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30025422 ID=SMED30025422|Name=GrpE protein homolog|organism=Schmidtea mediterranea sexual|type=transcript|length=779bp
GTTTATATTCGTTACATAATTTAAATTTTCAATCATGATTTCTGGAATAC
GAAAAGTTACTGCTTATACTTTGAGAAAAAACCCATATTTTTATCTAATT
TCAAATCGGTTATATTGTGATCAGTTGCCTGATTTAGATGATACTGTTAA
ACAACTTAGAGACGAAAATGCCAAACTTACTGATATATTTAAAGAAACAG
AAGATAAATATAAAAGGGCTTTGGCTGAATGCGAAAATGTTCGTCAGAGA
ATGTCACGTCAAGTAGAAGAAGCTAAACAATTTGGCATTCATAAATTTTG
TAAGGACTTGTTAGAAGTTGCAGATGTACTAACTACAGCAACACAAGCTG
TTAAAACTGAGGAGCTTGAAGAAAGTCAATATCTGAAGCAAATGTATGAT
GGTATGCAAATGACTGAATCTCAAATGTTAAAAGTATTTGCTCGTCACGG
CGTTGAACGCATTAGGCCGGAGATAGGGGAAAAATTTGATCCTAATTTTC
ATGAAGCCATGTTTCAAATTCCTGTTCCTAGTGATAAAGTGAAAGCAGAA
TTTGTCGGTACGGTTGCTGTGTGCAGCAAAGTTGGTTACAAATTATATCA
CAAAACATTGAGGCCAGCTACCGTCGGGGTTTTCCAGTAAATCTAAATTT
TGTCTGGTTTCTAAGTTGAATAAAATTATTGAATTTTATCTAACTTTGTA
AATTTGTATGAGCTTTTATGCATATATTAGATTTTTATTTTAAATTGAAA
AACAAAATTGAAATTATTTTATGAATTAG
back to top

protein sequence of SMED30025422-orf-1

>SMED30025422-orf-1 ID=SMED30025422-orf-1|Name=SMED30025422-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=202bp
MISGIRKVTAYTLRKNPYFYLISNRLYCDQLPDLDDTVKQLRDENAKLTD
IFKETEDKYKRALAECENVRQRMSRQVEEAKQFGIHKFCKDLLEVADVLT
TATQAVKTEELEESQYLKQMYDGMQMTESQMLKVFARHGVERIRPEIGEK
FDPNFHEAMFQIPVPSDKVKAEFVGTVAVCSKVGYKLYHKTLRPATVGVF
Q*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000429neoblast
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR000740GrpE
IPR013805GrpE_coiled_coil
IPR009012GrpE_head
Vocabulary: molecular function
TermDefinition
GO:0051087chaperone binding
GO:0000774adenyl-nucleotide exchange factor activity
GO:0042803protein homodimerization activity
Vocabulary: biological process
TermDefinition
GO:0006457protein folding
GO:0050790regulation of catalytic activity
Vocabulary: cellular component
TermDefinition
GO:0005739mitochondrion
GO:0005759mitochondrial matrix
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 38..83
NoneNo IPR availablePANTHERPTHR21237:SF23GRPE PROTEIN HOMOLOG, MITOCHONDRIALcoord: 35..201
IPR000740GrpE nucleotide exchange factorPRINTSPR00773GRPEPROTEINcoord: 148..163
score: 54.49
coord: 60..76
score: 41.36
coord: 88..103
score: 40.04
IPR000740GrpE nucleotide exchange factorPFAMPF01025GrpEcoord: 33..200
e-value: 1.2E-44
score: 151.9
IPR000740GrpE nucleotide exchange factorPANTHERPTHR21237GRPE PROTEINcoord: 35..201
IPR000740GrpE nucleotide exchange factorCDDcd00446GrpEcoord: 53..199
e-value: 8.11539E-52
score: 161.135
IPR013805GrpE nucleotide exchange factor, coiled-coilGENE3DG3DSA:3.90.20.20coord: 32..138
e-value: 1.1E-22
score: 81.6
IPR013805GrpE nucleotide exchange factor, coiled-coilSUPERFAMILYSSF58014Coiled-coil domain of nucleotide exchange factor GrpEcoord: 37..139
IPR009012GrpE nucleotide exchange factor, headGENE3DG3DSA:2.30.22.10coord: 139..201
e-value: 6.4E-13
score: 50.0
IPR009012GrpE nucleotide exchange factor, headSUPERFAMILYSSF51064Head domain of nucleotide exchange factor GrpEcoord: 144..200