tRNA-splicing endonuclease subunit Sen34

Overview
NametRNA-splicing endonuclease subunit Sen34
Smed IDSMED30025404
Length (bp)2720
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of tRNA-splicing endonuclease subunit Sen34 (SMED30025404) t-SNE clustered cells

Violin plots show distribution of expression levels for tRNA-splicing endonuclease subunit Sen34 (SMED30025404) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of tRNA-splicing endonuclease subunit Sen34 (SMED30025404) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for tRNA-splicing endonuclease subunit Sen34 (SMED30025404) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30025404

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
neuronSMED30025404SMESG000049881.1 dd_Smed_v4_4610_1_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
whole organism asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30025404SMESG000049881.1 dd_Smed_v4_4610_1_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
whole organism asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30025404SMESG000049881.1 dd_Smed_v4_4610_1_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
whole organism asexual adult single-cell RNA-sequencing evidence
neuronSMED30025404SMESG000049882.1 dd_Smed_v4_4610_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Fly
Match: CG33260 (gene:FBgn0053260 transcript:FBtr0302436)

HSP 1 Score: 65.855 bits (159), Expect = 3.082e-11
Identity = 38/105 (36.19%), Postives = 57/105 (54.29%), Query Frame = 3
Query: 1803 VKTAVFYNLWSRGHCVTVSCKKMGGDYLLYPGDPWFHHATHVVRILPQTLEIKPSQLISKIRLINSLKKTYLIAWYDDNAVAKSSNLSSIVEHLNISFNCLGWCG 2117
            +K  VF +LW RG  VT S    G D+L+YPGDP  +HA+H+V IL +   IKP +LI+K+RL   + K+ + A+  +N   +            I +  + WC 
Sbjct:  183 LKYRVFKDLWRRGKYVT-SGDAFGADFLVYPGDPMIYHASHIV-ILHEQPVIKPLELIAKVRLSVIVNKSCVFAYEMENNEEE------------IHYQTVAWCN 273          
BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Zebrafish
Match: tsen34 (TSEN34 tRNA splicing endonuclease subunit [Source:ZFIN;Acc:ZDB-GENE-050419-115])

HSP 1 Score: 51.9878 bits (123), Expect = 1.766e-6
Identity = 31/93 (33.33%), Postives = 53/93 (56.99%), Query Frame = 3
Query: 1785 LPLD--LVVKTAVFYNLWSRGHCVTVSCKKMGGDYLLYPGDPWFHHATHVVRILPQTLEIKPSQLISKIRLINSLKKTYLIAWYDDNAVAKSS 2057
            +P D  L  + +V+ +L ++G+ +T S  K GGD+L+YPGDP   HA ++   +    E+    +++  RL +++KKT L+    D  V  SS
Sbjct:  210 MPRDEHLNTRFSVYRDLRNKGYYLT-SAGKFGGDFLVYPGDPLRFHAHYIALCVSLDEEMPVCDILAIARLGSNVKKTVLLCSPQDGDVVYSS 301          
BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Zebrafish
Match: tsen34 (TSEN34 tRNA splicing endonuclease subunit [Source:ZFIN;Acc:ZDB-GENE-050419-115])

HSP 1 Score: 51.9878 bits (123), Expect = 1.766e-6
Identity = 31/93 (33.33%), Postives = 53/93 (56.99%), Query Frame = 3
Query: 1785 LPLD--LVVKTAVFYNLWSRGHCVTVSCKKMGGDYLLYPGDPWFHHATHVVRILPQTLEIKPSQLISKIRLINSLKKTYLIAWYDDNAVAKSS 2057
            +P D  L  + +V+ +L ++G+ +T S  K GGD+L+YPGDP   HA ++   +    E+    +++  RL +++KKT L+    D  V  SS
Sbjct:  210 MPRDEHLNTRFSVYRDLRNKGYYLT-SAGKFGGDFLVYPGDPLRFHAHYIALCVSLDEEMPVCDILAIARLGSNVKKTVLLCSPQDGDVVYSS 301          
BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Xenopus
Match: TSEN34 (tRNA splicing endonuclease subunit 34 [Source:NCBI gene;Acc:100380139])

HSP 1 Score: 88.1965 bits (217), Expect = 2.891e-18
Identity = 81/327 (24.77%), Postives = 144/327 (44.04%), Query Frame = 3
Query: 1224 VWDPDSVRFLRDECRIFGKFIGSVARLPHKTVFKGLPLMLAVEEF--------VVLLKEHSERVRLVRSISL---VSPLIPESSSASVDQYKSDIEHNY-NEISDIIQEMRLDRSNLHFDSVGDSQIQGRKRK----ADGARVSIAPSVAP-----DLEK--------VSVHLPTSTPTDWLRVGEKETIDIPKLLSLAEVTDFVISLLQRKFEQKLPLDLVVKTAVFYNLWSRGHCVTVSCKKMGGDYLLYPGDPWFHHATHVVRILPQTLEIKPSQLISKIRLINSLKKTYLIAWYDDNAVAKSSNLSSIVEHLNISFNCLGWCG 2117
            VW  D V+ +R++  + G  +G++ R P +    GLPL L  EE          VL++  S   ++ + ++L    +   P  +  + +Q +++    Y NE     +++ L+      +S+ D   +GR R+    +D    + +    P     +LE+        + VHLPT+ P+     G+ E +D      + + +       Q++ E        V+  VF +LW +G+ +T S  K GGD+L+YPGDP   HA  +    P   EI  S +++  RL  ++KKT L+   D+                 ++F  L W G
Sbjct:   13 VWKADDVQMIREQHGLVGNLVGALVRKPRQNSRLGLPLQLMPEEVRLLVEIGAAVLVRGLSGEGKIHKEVALEVESAESSPSPNDVNDEQPETEAYDKYLNESYKEQRKLALEDKRRTLESLADRIAEGRSRRKRQRSDQEDATESSFQGPIKELQNLEETFQFPKEAMMVHLPTAHPS----CGDTEEVD------MCQASVHWPYAGQKEHE--------VRYKVFKSLWQKGYFLT-SGSKFGGDFLVYPGDPMRFHAHFIAICFPYKEEIPLSDIVTAGRLGTNVKKTVLLCSADEGG--------------EVTFTSLQWSG 306          
BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Mouse
Match: Tsen34 (tRNA splicing endonuclease subunit 34 [Source:MGI Symbol;Acc:MGI:1913328])

HSP 1 Score: 62.003 bits (149), Expect = 9.982e-10
Identity = 71/301 (23.59%), Postives = 128/301 (42.52%), Query Frame = 3
Query: 1224 VWDPDSVRFLRDECRIFGKFIGSVARLPHKTVFKGLPLMLAVEEFVVLLKEHSERVRLVRSISLVSPLIPE--SSSASVDQYKSDIEHNYNEISDIIQEMRLDR----------------SNLHFDSVGD--SQIQGRKRKADGARVSIAPSVAPDLEKVSVHLPTSTPTDWLRVGEKETIDIPKLLSLAEVTDFVISLLQRKFEQKLPLDLVVKT---------------AVFYNLWSRGHCVTVSCKKMGGDYLLYPGDPWFHHATHVVRILPQTLEIKPSQLISKIRLINSLKKTYLI 2021
            VW  ++V+ LR+   + G+ +G++ R P +    GLPL+L  EE  +L +        + +++LVS   P+  +   ++  +K   E ++ + + +  E R  R                  L  DS  D   Q  G      G+  S     + + E  +  L +S+P      G      +P+   L ++       ++ K     PLD  V++               +++ +LW RG  ++ + K  GGD+L+YPGDP   HA ++ +       I    L+S  RL  S++KT L+
Sbjct:   13 VWGAEAVQALRERLGVGGRTVGALPRGPRQNSRLGLPLLLLPEEARLLAE--------IGAVTLVSAPRPDPRNHGLALASFKRQQEQSFQDQNTLAAEARETRRQELLEKIVEGQAAKKQKLEQDSGADEGGQEAGGSEATQGSETSDDGQPSAEQEGAAPSLDSSSPQPGPSNG---VTPLPRSALLIQLATARPRPVKAK-----PLDWRVQSKDWPHAGRPAHELRYSIYRDLWERGFFLSAAGK-FGGDFLVYPGDPLRFHAHYIAQCWSAEDPIPLQDLVSAGRLGTSVRKTLLL 296          
BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Mouse
Match: Tsen34 (tRNA splicing endonuclease subunit 34 [Source:MGI Symbol;Acc:MGI:1913328])

HSP 1 Score: 62.003 bits (149), Expect = 9.982e-10
Identity = 71/301 (23.59%), Postives = 128/301 (42.52%), Query Frame = 3
Query: 1224 VWDPDSVRFLRDECRIFGKFIGSVARLPHKTVFKGLPLMLAVEEFVVLLKEHSERVRLVRSISLVSPLIPE--SSSASVDQYKSDIEHNYNEISDIIQEMRLDR----------------SNLHFDSVGD--SQIQGRKRKADGARVSIAPSVAPDLEKVSVHLPTSTPTDWLRVGEKETIDIPKLLSLAEVTDFVISLLQRKFEQKLPLDLVVKT---------------AVFYNLWSRGHCVTVSCKKMGGDYLLYPGDPWFHHATHVVRILPQTLEIKPSQLISKIRLINSLKKTYLI 2021
            VW  ++V+ LR+   + G+ +G++ R P +    GLPL+L  EE  +L +        + +++LVS   P+  +   ++  +K   E ++ + + +  E R  R                  L  DS  D   Q  G      G+  S     + + E  +  L +S+P      G      +P+   L ++       ++ K     PLD  V++               +++ +LW RG  ++ + K  GGD+L+YPGDP   HA ++ +       I    L+S  RL  S++KT L+
Sbjct:   13 VWGAEAVQALRERLGVGGRTVGALPRGPRQNSRLGLPLLLLPEEARLLAE--------IGAVTLVSAPRPDPRNHGLALASFKRQQEQSFQDQNTLAAEARETRRQELLEKIVEGQAAKKQKLEQDSGADEGGQEAGGSEATQGSETSDDGQPSAEQEGAAPSLDSSSPQPGPSNG---VTPLPRSALLIQLATARPRPVKAK-----PLDWRVQSKDWPHAGRPAHELRYSIYRDLWERGFFLSAAGK-FGGDFLVYPGDPLRFHAHYIAQCWSAEDPIPLQDLVSAGRLGTSVRKTLLL 296          
BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Mouse
Match: Tsen34 (tRNA splicing endonuclease subunit 34 [Source:MGI Symbol;Acc:MGI:1913328])

HSP 1 Score: 60.8474 bits (146), Expect = 2.781e-9
Identity = 69/301 (22.92%), Postives = 126/301 (41.86%), Query Frame = 3
Query: 1224 VWDPDSVRFLRDECRIFGKFIGSVARLPHKTVFKGLPLMLAVEEFVVLLKEHSERVRLVRSISLVSPLIPE--SSSASVDQYKSDIEHNYNEISDIIQEMRLDR----------------SNLHFDSVGD--SQIQGRKRKADGARVSIAPSVAPDLEKVSVHLPTSTPTDWLRVGEKETIDIPKLLSLAEVTDFVISLLQRKFEQKLPLDLVVKT---------------AVFYNLWSRGHCVTVSCKKMGGDYLLYPGDPWFHHATHVVRILPQTLEIKPSQLISKIRLINSLKKTYLI 2021
            VW  ++V+ LR+   + G+ +G++ R P +    GLPL+L  EE  +L +        + +++LVS   P+  +   ++  +K   E ++ + + +  E R  R                  L  DS  D   Q  G      G+  S     + + E      P   P++ +         +P+   L ++       ++ K     PLD  V++               +++ +LW RG  ++ + K  GGD+L+YPGDP   HA ++ +       I    L+S  RL  S++KT L+
Sbjct:   13 VWGAEAVQALRERLGVGGRTVGALPRGPRQNSRLGLPLLLLPEEARLLAE--------IGAVTLVSAPRPDPRNHGLALASFKRQQEQSFQDQNTLAAEARETRRQELLEKIVEGQAAKKQKLEQDSGADEGGQEAGGSEATQGSETSDDGQPSAEQEGADSSSPQPGPSNGV-------TPLPRSALLIQLATARPRPVKAK-----PLDWRVQSKDWPHAGRPAHELRYSIYRDLWERGFFLSAAGK-FGGDFLVYPGDPLRFHAHYIAQCWSAEDPIPLQDLVSAGRLGTSVRKTLLL 292          
BLAST of tRNA-splicing endonuclease subunit Sen34 vs. TrEMBL
Match: A0A3P7L0I8 (tRNA_int_endo domain-containing protein OS=Dibothriocephalus latus OX=60516 GN=DILT_LOCUS6015 PE=4 SV=1)

HSP 1 Score: 108.227 bits (269), Expect = 1.474e-22
Identity = 60/174 (34.48%), Postives = 95/174 (54.60%), Query Frame = 3
Query: 1641 VSVHLPTSTPTDWLRVGEKETIDIPKLL---SLAEVTDFVISLLQRKFEQKLPL-----------DLVVKTAVFYNLWSRGHCVTVSCKKMGGDYLLYPGDPWFHHATHVVRILPQTLEIKPSQLISKIRLINSLKKTYLIAWYDDNAVAKSSNLSSIVEHLNISFNCLGWCGS 2120
            V +H P +TP +W R GE + +++P  L    L  +  ++I+L  +       +           + ++K  VF +LWS+G CVT S  KMGGD+LLYPGDP F+HA+H+V + P T ++K +QL + +R+ NS++K  L+A    +AV +            I +  L W GS
Sbjct:   63 VPIHRPRATPREWRRPGEHQQLEVPADLHADGLPAIVRWLITLSAKARASAACMPDSAVPKVDEEETILKCRVFADLWSKGFCVTGSAMKMGGDFLLYPGDPLFYHASHIVCVAPPTSQLKLAQLSTSLRIANSVRKVLLLA---TSAVKEGEE--------PIMYTSLYWTGS 225          
BLAST of tRNA-splicing endonuclease subunit Sen34 vs. TrEMBL
Match: A0A402FD12 (tRNA-splicing endonuclease subunit Sen34 OS=Paroedura picta OX=143630 GN=parPi_0016452 PE=3 SV=1)

HSP 1 Score: 103.605 bits (257), Expect = 2.875e-20
Identity = 82/307 (26.71%), Postives = 139/307 (45.28%), Query Frame = 3
Query: 1224 VWDPDSVRFLRDECRIFGKFIGSVARLPHKTVFKGLPLMLAVEEFVVLLKEHSERVRLVRSISLVSPLIPESSS-----ASVDQYKSDIEHNYNEISDIIQEMRLDRSNLHFDSVGDSQIQGRKRKADGARVSIAPSVAPDLEKVSVH----LPTSTPTDWLRVGEKETIDIPKLLSLAEVTDFVISLLQRKFEQKLPLDLVVKTAVFYNLWSRGHCVTVSCKKMGGDYLLYPGDPWFHHATHVVRILPQTLEIKPSQLISKIRLINSLKKTYLIAWYDDNAVAKSSNLSSIVEHLNISFNCLGWCG 2117
            VW+ D  + +R+E R+ G  +G++AR P + V  GLPL L  EE  +L ++      L+++++   PL  E+        +V  Y+ D E +Y E   +  E R        + +   + + R+RK   A  +  P+   DLE   V     +    PT+  + G++E +D                L  +++      +  ++  VF NLW +G+ +T S  K GGD+L+YPGDP   HA  +   +P+   +    +IS  RL  S+KKT L+   D +               N+++  L W G
Sbjct:   41 VWNADDAQRIREEHRVVGTLVGALARKPRQNVRLGLPLQLLPEEARLLAEKGV--ATLLKNLT-SHPLTEEAGQDPSFLEAVAAYQKDQEESYQEQVRLAGEQRKALMGTLAERIAQGRAKKRQRKGGEAEPASKPA---DLESSFVFPREAMMVQLPTERTQRGQEEEVDW--------------RLPSKEWPYGRQPEHEMRFRVFQNLWEQGYYIT-SGSKFGGDFLVYPGDPMRFHAHFIALCVPRDTPLSLCDIISVGRLGTSVKKTVLLCSVDQDG--------------NVAYTSLQWSG 312          
BLAST of tRNA-splicing endonuclease subunit Sen34 vs. TrEMBL
Match: A0A183TSN8 (tRNA_int_endo domain-containing protein OS=Schistocephalus solidus OX=70667 GN=SSLN_LOCUS19486 PE=4 SV=1)

HSP 1 Score: 103.605 bits (257), Expect = 3.355e-20
Identity = 58/158 (36.71%), Postives = 87/158 (55.06%), Query Frame = 3
Query: 1605 SIAPSVAPDLEK----VSVHLPTSTPTDWLRVGEKETIDIPKLL---SLAEVTDFVISLLQRK-----------FEQKLPLDLVVKTAVFYNLWSRGHCVTVSCKKMGGDYLLYPGDPWFHHATHVVRILPQTLEIKPSQLISKIRLINSLKKTYLIA 2024
            S A    P  E+    V +H P  TP +W R GE + +D+P  L    L  +  ++I+L  +              Q      ++K  VF +LWS+G CVT S  KMGG +LLYPGDP F+HA+H+V + P T ++K +QL + +R+ NS++K  L+A
Sbjct:  108 SYAGGTQPSTEQLHASVPIHRPRPTPREWRRHGEHQQLDVPAHLHTEGLPAIVRWLITLSSKARTSAANSSDSVVPQVDEEKTLLKCRVFMDLWSKGFCVTGSAMKMGGHFLLYPGDPLFYHASHIVCVAPATSQLKLAQLSTSLRIANSVRKVLLLA 265          
BLAST of tRNA-splicing endonuclease subunit Sen34 vs. TrEMBL
Match: H9GMZ3 (tRNA-splicing endonuclease subunit Sen34 OS=Anolis carolinensis OX=28377 GN=TSEN34 PE=3 SV=1)

HSP 1 Score: 97.0561 bits (240), Expect = 4.393e-18
Identity = 88/303 (29.04%), Postives = 137/303 (45.21%), Query Frame = 3
Query: 1224 VWDPDSVRFLRDECRIFGKFIGSVARLPHKTVFKGLPLMLAVEEFVVLLKEHSERVRLVRSISLVSPLIPESSSASVDQYKSDIEHNYNEISDIIQEMRLDRSNLHFDSVGDSQIQGRKRKADGARVSIA-----PSVAPDLEKVSVHLPT-------STPTDWLRVGEKE-TIDIPKLLSLAEVTDFVISLLQ------RKFEQKLPL----DLVVKTAVFYNLWSRGHCVTVSCKKMGGDYLLYPGDPWFHHATHVVRILPQTLEIKPSQLISKIRLINSLKKTYLIAWYDDNAVAKSSNL 2063
            VW+   VR +R+E RI G   G++AR P + V  GLPL L  EE  +LL    E    +   +  SP + E +S  V  Y+ ++E NY E   +  E R        D++ +   QGR +K              PS    L + S  +PT       S P    ++ E E +  +P+   + ++    I+  Q      R   +  P     D      +F NLW RG  VT S  K GG++L+YPGDP   HA ++   +P+   +    +IS  RL +++KKT L+   D++     ++L
Sbjct:   13 VWNYADVRRIREEHRIVGTLFGALARKPRQNVRLGLPLQLLPEEARLLL----ENGLAILCKNPASPALGEDTSQEVAVYQKELEENYQEQCRLAAEQR----KALLDTLAERIAQGRAKKRQREGEEEGEQHCYPS---QLWRGSWMMPTGSDPPLLSFPESSSKLAEPEPSFVLPRDSMMVQLPTERINPGQEVVVDWRVPSKDWPYAGQPDHEAHYRIFRNLWERGFYVT-SGSKFGGNFLVYPGDPMRFHAHYIALCVPRDTPLSLCDIISAGRLGSNVKKTVLLCSADEDGTVVYTSL 303          
BLAST of tRNA-splicing endonuclease subunit Sen34 vs. TrEMBL
Match: A0A151M4W1 (tRNA-splicing endonuclease subunit Sen34 OS=Alligator mississippiensis OX=8496 GN=TSEN34 PE=3 SV=1)

HSP 1 Score: 96.2857 bits (238), Expect = 4.825e-18
Identity = 83/299 (27.76%), Postives = 129/299 (43.14%), Query Frame = 3
Query: 1209 AAEIAVWDPDSVRFLRDECRIFGKFIGSVARLPHKTVFKGLPLMLAVEEFVVLLKEHSERVRLVRSISLVSPLIPESSSASVDQ---YKSDIEHNYNEISDIIQEMRLDRSNLHFDSVGDSQIQGRKRKAD--GARVSIAPSVAPDLEKVSVH---------LPTSTPTDWLRVGEKETIDIPKLLSLAEVTDFVISLLQRKFEQKLPLDLVVKTAVFYNLWSRGHCVTVSCKKMGGDYLLYPGDPWFHHATHVVRILPQTLEIKPSQLISKIRLINSLKKTYLIAWYDDNAVAKSSNL 2063
            A +  VW  +  R +R+  R+ G  +G++AR P + V  GLPL L  EE   LL E    V LVRS        P+  SA   +   Y+  +E +Y E   +  + R  +      ++ +   QGR RK    G     AP   P  E+  +          +    PT W   G++E +D               +   R +      +   +  VF +LW RG+ VT S  K GGD+L+YPGDP   HA ++    P    +    +++  RL  S+KKT L+    ++ V   ++L
Sbjct:    8 AGQALVWRFEDAREIRERHRLVGTLVGALARTPRQNVRLGLPLQLLPEE-ARLLAEMGAAV-LVRSADAQ----PQGQSAQASEGQLYEQGLEESYQEQRRLAAQERWAQ----LANLAECIAQGRARKQQQRGKLPDTAPLPGPTEEQEHLESAFVFPHESMMVQLPTVWPCPGQEEQVDW--------------TQPSRDWPHAGHQEHETRYCVFRDLWGRGYYVT-SGSKFGGDFLVYPGDPMRFHAHYIALCCPPGAPLPLCDIVAAARLGTSVKKTVLLCSAGEDGVVIYTSL 281          
BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Nematostella
Match: EDO32072 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SW35])

HSP 1 Score: 58.9214 bits (141), Expect = 1.095e-10
Identity = 34/92 (36.96%), Postives = 50/92 (54.35%), Query Frame = 3
Query: 1803 VKTAVFYNLWSRGHCVTVSCKKMGGDYLLYPGDPWFHHATHVVRILPQTLEIKPSQLISKIRLINSLKKTYLIAWYDD--NAVAKSSNLSSI 2072
            ++ ++F NLW RG  +T  CK  GGD+L YPGDP   H+ ++V ++P         ++S  RL  ++KKT + A  D   N V  S   S I
Sbjct:   11 LRYSIFKNLWERGLYITSGCK-FGGDFLAYPGDPVKFHSFYIVVVVPYDKRTGMLDVVSMGRLGATVKKTAVFASMDSGGNVVYMSVKWSGI 101          
BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Planmine SMEST
Match: SMESG000049881.1 (SMESG000049881.1)

HSP 1 Score: 637.876 bits (1644), Expect = 0.000e+0
Identity = 312/314 (99.36%), Postives = 313/314 (99.68%), Query Frame = 3
Query: 1185 MVEITINSAAEIAVWDPDSVRFLRDECRIFGKFIGSVARLPHKTVFKGLPLMLAVEEFVVLLKEHSERVRLVRSISLVSPLIPESSSASVDQYKSDIEHNYNEISDIIQEMRLDRSNLHFDSVGDSQIQGRKRKADGARVSIAPSVAPDLEKVSVHLPTSTPTDWLRVGEKETIDIPKLLSLAEVTDFVISLLQRKFEQKLPLDLVVKTAVFYNLWSRGHCVTVSCKKMGGDYLLYPGDPWFHHATHVVRILPQTLEIKPSQLISKIRLINSLKKTYLIAWYDDNAVAKSSNLSSIVEHLNISFNCLGWCGSVP 2126
            MVEITIN+AAEIAVWDPDSVRFLRDECRIFGKFIGSVARLPHKTVFKGLPLMLAVEEFVVLLKEHSERVRLVRSISLVSPLIPESSSASVDQYKSDIEHNYNEISDIIQEMRLDRSNLHFDSVGDSQIQGRKRKADGARVSIAPSVAPDLEKVSVHLPTSTPTDWLRVGEKETIDIPKLLSLAEVTDFVISLLQRKFEQKLPLD VVKTAVFYNLWSRGHCVTVSCKKMGGDYLLYPGDPWFHHATHVVRILPQTLEIKPSQLISKIRLINSLKKTYLIAWYDDNAVAKSSNLSSIVEHLNISFNCLGWCGSVP
Sbjct:    1 MVEITINNAAEIAVWDPDSVRFLRDECRIFGKFIGSVARLPHKTVFKGLPLMLAVEEFVVLLKEHSERVRLVRSISLVSPLIPESSSASVDQYKSDIEHNYNEISDIIQEMRLDRSNLHFDSVGDSQIQGRKRKADGARVSIAPSVAPDLEKVSVHLPTSTPTDWLRVGEKETIDIPKLLSLAEVTDFVISLLQRKFEQKLPLDHVVKTAVFYNLWSRGHCVTVSCKKMGGDYLLYPGDPWFHHATHVVRILPQTLEIKPSQLISKIRLINSLKKTYLIAWYDDNAVAKSSNLSSIVEHLNISFNCLGWCGSVP 314          
BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Planmine SMEST
Match: SMESG000049882.1 (SMESG000049882.1)

HSP 1 Score: 255.373 bits (651), Expect = 9.014e-79
Identity = 121/122 (99.18%), Postives = 122/122 (100.00%), Query Frame = 2
Query:  671 ACPMFPERALDLTSTFRPKVFINPCSALSFGPSQMATGDSDSFQCQYPINLTIHHHSNGYYAYDSPVPIDLSYQTFWNSNHSSQPINFTNLLNSTSCPLDLTLDQSYSHEYDSNSTEIGWIC 1036
            ACPMFPERALDLTSTFRPKVFINPCSALSFGPSQMATGDSDSFQCQYPINLTIHHHSNGYYAYDSPVPIDLSYQTFWNSNHSSQPINFTNLLNSTSCPLDLTLDQSYSHEYDSNS+EIGWIC
Sbjct:  105 ACPMFPERALDLTSTFRPKVFINPCSALSFGPSQMATGDSDSFQCQYPINLTIHHHSNGYYAYDSPVPIDLSYQTFWNSNHSSQPINFTNLLNSTSCPLDLTLDQSYSHEYDSNSSEIGWIC 226          

HSP 2 Score: 174.866 bits (442), Expect = 1.777e-49
Identity = 103/105 (98.10%), Postives = 103/105 (98.10%), Query Frame = 1
Query:  163 MRRHNNKNLVFQCPCCPRVYRDPSSLRRHKRLYEHKKNXXXXXXXXXXXXXXXXMNLSCEIPQSRKIITTQEEVIIKTTLPSIDTFAFNHSAIDCRINNSKDNQV 477
            MRRHNNKNLVFQCPCCPRVYRDPSSLRRHKRLYEHKKNIEQEPEIPTPETVVIPMNLSCEI QSRKIITTQEEVIIKTTLPSIDTFAFNHSAIDCRINNSKDNQ 
Sbjct:    1 MRRHNNKNLVFQCPCCPRVYRDPSSLRRHKRLYEHKKNIEQEPEIPTPETVVIPMNLSCEITQSRKIITTQEEVIIKTTLPSIDTFAFNHSAIDCRINNSKDNQA 105          
BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Planmine SMEST
Match: SMESG000049882.1 (SMESG000049882.1)

HSP 1 Score: 255.758 bits (652), Expect = 1.398e-78
Identity = 121/122 (99.18%), Postives = 122/122 (100.00%), Query Frame = 2
Query:  671 ACPMFPERALDLTSTFRPKVFINPCSALSFGPSQMATGDSDSFQCQYPINLTIHHHSNGYYAYDSPVPIDLSYQTFWNSNHSSQPINFTNLLNSTSCPLDLTLDQSYSHEYDSNSTEIGWIC 1036
            ACPMFPERALDLTSTFRPKVFINPCSALSFGPSQMATGDSDSFQCQYPINLTIHHHSNGYYAYDSPVPIDLSYQTFWNSNHSSQPINFTNLLNSTSCPLDLTLDQSYSHEYDSNS+EIGWIC
Sbjct:  127 ACPMFPERALDLTSTFRPKVFINPCSALSFGPSQMATGDSDSFQCQYPINLTIHHHSNGYYAYDSPVPIDLSYQTFWNSNHSSQPINFTNLLNSTSCPLDLTLDQSYSHEYDSNSSEIGWIC 248          

HSP 2 Score: 218.779 bits (556), Expect = 6.727e-65
Identity = 125/127 (98.43%), Postives = 125/127 (98.43%), Query Frame = 1
Query:   97 MSKHKCPECNKCFQNRSRKSLCMRRHNNKNLVFQCPCCPRVYRDPSSLRRHKRLYEHKKNXXXXXXXXXXXXXXXXMNLSCEIPQSRKIITTQEEVIIKTTLPSIDTFAFNHSAIDCRINNSKDNQV 477
            MSKHKCPECNKCFQNRSRKSLCMRRHNNKNLVFQCPCCPRVYRDPSSLRRHKRLYEHKKNIEQEPEIPTPETVVIPMNLSCEI QSRKIITTQEEVIIKTTLPSIDTFAFNHSAIDCRINNSKDNQ 
Sbjct:    1 MSKHKCPECNKCFQNRSRKSLCMRRHNNKNLVFQCPCCPRVYRDPSSLRRHKRLYEHKKNIEQEPEIPTPETVVIPMNLSCEITQSRKIITTQEEVIIKTTLPSIDTFAFNHSAIDCRINNSKDNQA 127          
The following BLAST results are available for this feature:
BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
CG332603.082e-1136.19gene:FBgn0053260 transcript:FBtr0302436[more]
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BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
tsen341.766e-633.33TSEN34 tRNA splicing endonuclease subunit [Source:... [more]
tsen341.766e-633.33TSEN34 tRNA splicing endonuclease subunit [Source:... [more]
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BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
TSEN342.891e-1824.77tRNA splicing endonuclease subunit 34 [Source:NCBI... [more]
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BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Tsen349.982e-1023.59tRNA splicing endonuclease subunit 34 [Source:MGI ... [more]
Tsen349.982e-1023.59tRNA splicing endonuclease subunit 34 [Source:MGI ... [more]
Tsen342.781e-922.92tRNA splicing endonuclease subunit 34 [Source:MGI ... [more]
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BLAST of tRNA-splicing endonuclease subunit Sen34 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of tRNA-splicing endonuclease subunit Sen34 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A3P7L0I81.474e-2234.48tRNA_int_endo domain-containing protein OS=Dibothr... [more]
A0A402FD122.875e-2026.71tRNA-splicing endonuclease subunit Sen34 OS=Paroed... [more]
A0A183TSN83.355e-2036.71tRNA_int_endo domain-containing protein OS=Schisto... [more]
H9GMZ34.393e-1829.04tRNA-splicing endonuclease subunit Sen34 OS=Anolis... [more]
A0A151M4W14.825e-1827.76tRNA-splicing endonuclease subunit Sen34 OS=Alliga... [more]
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BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO320721.095e-1036.96Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of tRNA-splicing endonuclease subunit Sen34 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000049881.10.000e+099.36SMESG000049881.1[more]
SMESG000049882.19.014e-7999.18SMESG000049882.1[more]
SMESG000049882.11.398e-7899.18SMESG000049882.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30025404 ID=SMED30025404|Name=tRNA-splicing endonuclease subunit Sen34|organism=Schmidtea mediterranea sexual|type=transcript|length=2720bp
ATTTAAATATGGTAAATATTTGTACAAAAATGTCTCAAATCCTTTTTACT
TAAATTTTATATATTTATTTGTCATAAAAATATTTAAATAATTTTCATGT
CTAAACATAAATGCCCTGAATGCAATAAATGCTTTCAAAATCGCTCAAGG
AAGAGCTTATGTATGAGAAGGCATAATAATAAAAATTTAGTATTCCAGTG
TCCTTGTTGTCCTCGCGTGTATAGAGATCCAAGCAGCTTAAGAAGACACA
AAAGACTCTATGAACATAAAAAAAATATCGAACAGGAACCTGAAATACCT
ACGCCTGAAACTGTTGTAATTCCTATGAATCTCAGTTGTGAAATTCCTCA
ATCTCGTAAAATTATTACAACCCAAGAGGAAGTTATTATTAAAACAACCT
TGCCATCAATTGACACATTTGCTTTTAACCACTCAGCAATTGACTGCAGA
ATTAACAATTCCAAAGACAATCAGGTTTTATATTATGCAATTTTTGTAAA
TCTTATTTTTAATAATTTTTATTTTTGATGAAATATTTGAATGTTATTAA
TTATTGTTTATTACTGTTTGTTACCACCTAGTCTCGATGTGCGCTTGATC
CCGGCGGTTCCCCATTGACTGGATTGGGCCGACAGTGCCTCTGCCATCGA
TTTCATATCGTTTCATTTAGGCATGTCCAATGTTCCCCGAACGAGCTCTA
GATCTTACTTCGACGTTCCGGCCGAAAGTCTTCATCAATCCATGCTCGGC
ACTCTCATTTGGACCGTCTCAAATGGCAACTGGAGACAGCGACAGTTTCC
AATGCCAATATCCGATCAATTTGACCATTCACCACCATTCCAACGGCTAC
TATGCCTACGATTCCCCGGTTCCGATCGATCTGAGCTATCAGACATTCTG
GAACTCAAATCACAGCTCTCAGCCAATCAACTTCACGAACCTCCTCAACA
GCACTTCCTGTCCGCTCGATCTCACATTGGATCAGTCGTATTCGCATGAA
TACGACAGCAATTCCACCGAGATCGGCTGGATTTGTTGATGGATTTCTAT
GAATAAATTGATATCTTGATTTTCATTGGCTGTTGATTTTGATTGGCTGT
TTTATTTGTTTGTAATTATTTGTTTTAATATCAATAATTTTGCGTTTAAT
GAATTTAGTCTGTGAAATTGGCAGGTTTCAGCAGATGGTCGAGATAACAA
TCAATAGTGCAGCCGAGATTGCCGTTTGGGATCCTGATTCCGTCAGATTC
CTTCGTGACGAATGCCGCATTTTCGGGAAATTTATCGGTTCTGTTGCTAG
GCTGCCACATAAAACAGTTTTCAAGGGGCTCCCGTTAATGCTGGCAGTTG
AGGAGTTTGTGGTACTTCTAAAGGAACATTCGGAACGGGTCAGGCTGGTG
CGCAGCATTAGCTTAGTATCGCCATTAATACCGGAATCGTCATCTGCCAG
TGTAGACCAATACAAATCAGATATCGAGCATAATTATAACGAAATATCTG
ATATCATCCAGGAAATGAGACTAGATAGGTCGAACCTGCATTTCGACAGT
GTGGGTGACAGCCAGATTCAAGGACGGAAACGGAAAGCAGATGGCGCCCG
TGTTAGCATTGCTCCTTCAGTAGCTCCCGACTTAGAGAAGGTTTCTGTAC
ATTTGCCCACATCTACCCCGACCGATTGGTTGCGAGTAGGTGAGAAAGAA
ACTATTGACATTCCCAAACTGTTGTCATTGGCTGAAGTCACAGATTTCGT
TATAAGCTTATTGCAACGTAAATTTGAACAGAAACTTCCACTAGATCTCG
TGGTCAAAACTGCAGTTTTCTATAATCTTTGGTCTAGAGGCCATTGCGTC
ACTGTATCTTGCAAGAAAATGGGAGGGGATTATCTCCTCTATCCTGGTGA
TCCCTGGTTTCATCACGCCACACATGTCGTCAGGATTCTGCCGCAAACCT
TGGAAATAAAACCGTCTCAATTGATCTCCAAAATCCGACTGATTAACAGC
TTGAAAAAGACATATTTAATTGCTTGGTACGATGACAATGCCGTTGCCAA
GTCATCAAACTTATCAAGCATTGTAGAACATTTGAACATCAGTTTTAATT
GCCTCGGTTGGTGTGGGAGTGTTCCGTGATAATATTGGTATTTTGGGGAT
CATTTAGCAATACATTTTATGTCTTAAATCCCTTTAAATTTGTTGATCTT
GTCGTGAATTATTGCTTGGCTGTGAGTAATGGACTGCTGCAGTGTGATTT
GTGATTTATATTTTACCCTTGACTCCAAGTGGCTCACCGTTCCAGTGACA
CCTCACGATAATATATATATTTAAAATGTAAAAAACCGTCCTATATTGAT
TACATCCGGTCTTATTGGACAAAATTTTCTATAATTAAAAAACACGATTT
AAACACCAAATGGTATTTGACATTAATTAAACATTTCAAAAATATAAATA
ACATCTACCTGCATCAAATGGCAATCAGCAAAGGCTTGAATGATTATAAG
TAAGAGCATCAATTATATAAAAAACTAACCAATAATAAAAGTCATTTCAC
AACAGGAAAATATAGAAAATTTTAATACTAGAAGAAAAATAAATTCTTAC
ATAGAAGCTCGGTGTATAAATTTTCTATAATTAGAAAATACTTTAGACAA
TAAATAAAGGACTTGACAATTGGTAAGGCCATCATATGAAATATAAAAAA
GAAAATTTCGAAGCTTCCAC
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protein sequence of SMED30025404-orf-1

>SMED30025404-orf-1 ID=SMED30025404-orf-1|Name=SMED30025404-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=144bp
MSKHKCPECNKCFQNRSRKSLCMRRHNNKNLVFQCPCCPRVYRDPSSLRR
HKRLYEHKKNIEQEPEIPTPETVVIPMNLSCEIPQSRKIITTQEEVIIKT
TLPSIDTFAFNHSAIDCRINNSKDNQVLYYAIFVNLIFNNFYF*
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protein sequence of SMED30025404-orf-2

>SMED30025404-orf-2 ID=SMED30025404-orf-2|Name=SMED30025404-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=327bp
MNLVCEIGRFQQMVEITINSAAEIAVWDPDSVRFLRDECRIFGKFIGSVA
RLPHKTVFKGLPLMLAVEEFVVLLKEHSERVRLVRSISLVSPLIPESSSA
SVDQYKSDIEHNYNEISDIIQEMRLDRSNLHFDSVGDSQIQGRKRKADGA
RVSIAPSVAPDLEKVSVHLPTSTPTDWLRVGEKETIDIPKLLSLAEVTDF
VISLLQRKFEQKLPLDLVVKTAVFYNLWSRGHCVTVSCKKMGGDYLLYPG
DPWFHHATHVVRILPQTLEIKPSQLISKIRLINSLKKTYLIAWYDDNAVA
KSSNLSSIVEHLNISFNCLGWCGSVP*
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protein sequence of SMED30025404-orf-3

>SMED30025404-orf-3 ID=SMED30025404-orf-3|Name=SMED30025404-orf-3|organism=Schmidtea mediterranea sexual|type=polypeptide|length=120bp
MFPERALDLTSTFRPKVFINPCSALSFGPSQMATGDSDSFQCQYPINLTI
HHHSNGYYAYDSPVPIDLSYQTFWNSNHSSQPINFTNLLNSTSCPLDLTL
DQSYSHEYDSNSTEIGWIC*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0000101muscle cell
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR036167tRNA_intron_Endo_cat-like_sf
IPR006677tRNA_intron_Endonuc_cat-like
IPR011856tRNA_endonuc-like_dom_sf
IPR015880Znf_C2H2-like
IPR007087Znf_C2H2
Vocabulary: biological process
TermDefinition
GO:0006388tRNA splicing, via endonucleolytic cleavage and ligation
GO:0090305nucleic acid phosphodiester bond hydrolysis
GO:0090501RNA phosphodiester bond hydrolysis
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic
Vocabulary: molecular function
TermDefinition
GO:0000213tRNA-intron endonuclease activity
GO:0003676nucleic acid binding
GO:0004518nuclease activity
GO:0046872metal ion binding
GO:0004519endonuclease activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR011856tRNA endonuclease-like domain superfamilyGENE3DG3DSA:3.40.1350.10coord: 217..307
e-value: 8.8E-16
score: 59.8
IPR006677tRNA intron endonuclease, catalytic domain-likePFAMPF01974tRNA_int_endocoord: 219..297
e-value: 5.4E-11
score: 42.4
NoneNo IPR availablePANTHERPTHR13070TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATEDcoord: 11..298
IPR036167tRNA intron endonuclease, catalytic domain-like superfamilySUPERFAMILYSSF53032tRNA-intron endonuclease catalytic domain-likecoord: 218..297