Voltage-dependent calcium channel subunit alpha-2/delta-2

Overview
NameVoltage-dependent calcium channel subunit alpha-2/delta-2
Smed IDSMED30025296
Length (bp)3620
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Voltage-dependent calcium channel subunit alpha-2/delta-2 (SMED30025296) t-SNE clustered cells

Violin plots show distribution of expression levels for Voltage-dependent calcium channel subunit alpha-2/delta-2 (SMED30025296) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Voltage-dependent calcium channel subunit alpha-2/delta-2 (SMED30025296) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Voltage-dependent calcium channel subunit alpha-2/delta-2 (SMED30025296) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30025296

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 26

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30025296h1SMcG0002719 SmedASXL_014162SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30025296h1SMcG0002719 SmedASXL_014162SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X1 cellSMED30025296h1SMcG0002719 SmedASXL_014162SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30025296h1SMcG0002719 SmedASXL_014162SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
nervous systemSMED30025296h1SMcG0002720 dd_Smed_v4_38777_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30025296h1SMcG0002720 Contig36721newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
nervous systemSMED30025296h1SMcG0002719 dd_Smed_v4_2470_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30025296h1SMcG0002719 dd_Smed_v4_2470_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30025296h1SMcG0002719 dd_Smed_v4_2470_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30025296h1SMcG0002719 dd_Smed_v4_2470_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30025296h1SMcG0002719 dd_Smed_v4_2470_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30025296h1SMcG0002719 dd_Smed_v4_2470_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30025296h1SMcG0002720 Contig31644newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30025296h1SMcG0002720 Contig31644uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30025296h1SMcG0023063 Contig36721newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
nervous systemSMED30025296h1SMcG0002720 dd_Smed_v4_38777_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30025296h1SMcG0002720 Contig36721newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
nervous systemSMED30025296h1SMcG0002719 dd_Smed_v4_2470_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30025296h1SMcG0002719 dd_Smed_v4_2470_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30025296h1SMcG0002719 dd_Smed_v4_2470_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30025296h1SMcG0002719 dd_Smed_v4_2470_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30025296h1SMcG0002719 dd_Smed_v4_2470_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30025296h1SMcG0002719 dd_Smed_v4_2470_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30025296h1SMcG0002720 Contig31644newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30025296h1SMcG0002720 Contig31644uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30025296h1SMcG0023063 Contig36721newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Human
Match: CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:HGNC Symbol;Acc:HGNC:1400])

HSP 1 Score: 284.648 bits (727), Expect = 3.280e-79
Identity = 183/620 (29.52%), Postives = 319/620 (51.45%), Query Frame = 2 
Query:  119 LQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRK-KGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-------FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            L+ E D  MR    V Q   +  IY +   +   E     P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK  + ILN L WT+ L N+F+   R    L +Q F S TG+   YP   WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +    + +    ++   +V ED          +GLGL+ + T+PV+N + +G         LG++G D+ +  +  L P+  LG NGY FAI+ NGY++ HP LK Q    R+P  +D  + E + + K +IR  +I+         G   + +L+K  DE +  E +R Y++  +  + + + +V   Y+ +Y
Sbjct:    8 LEQEVDGVMRIFGGVQQ---LREIYKD--NRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKEAK----QVQWTNVYEDA---------LGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMID------GNKGHKQIRTLVKSLDERYIDEVTRNYTWVPIRSTNYSLGLVLPPYSTFY 579

HSP 2 Score: 92.8189 bits (229), Expect = 2.886e-18
Identity = 106/444 (23.87%), Postives = 192/444 (43.24%), Query Frame = 2 
Query: 2258 RDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEK-VEKFLKRSD----SLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYE--ACNKTR------------------------LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATAT---DNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNT--QPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN 3481
            R+   +++  D  T+F    I+++  +   S  +C ++    LI D  + ++ VE+  +  D    SL +V  +T  G++ V P      + +  +   N++ ++R+ D   ++F      QD    P    N++   L V  +  +++    + P AV+G+   +L L +  +K++  A N+T                         LC LI+DGG+++  N      QVG FF ++   +M  L NNS +   E +DYQA C  +    + ++   +   T    + +        +     LF +LL  L    +  A  A A    + +  SC+ K  ++YF   S+N+    I   C NC+   +  R+  +NL+ V  ++  CS  C      Q   +   D GP+ C+L   PRYR  P + C+ +N  E+   C 
Sbjct:  613 REYCKDLNASDNNTEFLKNFIELMEKVTPDSK-QCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEP-FNASFYRRSLDNHGYVFKPPH--QDALLRPLELENDTVGIL-VSTAVELSLGRRTLRP-AVVGV---KLDLEAWAEKFKVLASNRTHQDQPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAW----SLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYF--GSVNASYNAIID-CGNCSRLFHAQRLTNTNLLFVVAEKPLCS-QCEAGRLLQKETHCPAD-GPEQCELVQRPRYRRGP-HICFDYNATEDTSDCG 1037
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Human
Match: CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:HGNC Symbol;Acc:HGNC:1400])

HSP 1 Score: 285.034 bits (728), Expect = 5.831e-79
Identity = 183/620 (29.52%), Postives = 319/620 (51.45%), Query Frame = 2 
Query:  119 LQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRK-KGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-------FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            L+ E D  MR    V Q   +  IY +   +   E     P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK  + ILN L WT+ L N+F+   R    L +Q F S TG+   YP   WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +    + +    ++   +V ED          +GLGL+ + T+PV+N + +G         LG++G D+ +  +  L P+  LG NGY FAI+ NGY++ HP LK Q    R+P  +D  + E + + K +IR  +I+         G   + +L+K  DE +  E +R Y++  +  + + + +V   Y+ +Y
Sbjct:   77 LEQEVDGVMRIFGGVQQ---LREIYKD--NRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKEAK----QVQWTNVYEDA---------LGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMID------GNKGHKQIRTLVKSLDERYIDEVTRNYTWVPIRSTNYSLGLVLPPYSTFY 648

HSP 2 Score: 92.8189 bits (229), Expect = 3.103e-18
Identity = 106/445 (23.82%), Postives = 191/445 (42.92%), Query Frame = 2 
Query: 2258 RDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEK-VEKFLKRSD----SLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYE--ACNKTR-------------------------LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATA---TDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNT--QPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN 3481
            R+   +++  D  T+F    I+++  +   S  +C ++    LI D  + ++ VE+  +  D    SL +V  +T  G++ V P      + +  +   N++ ++R+ D   ++F      QD    P    N++   L V  +  +++    + P AV+G+ L    L +  +K++  A N+T                          LC LI+DGG+++  N      QVG FF ++   +M  L NNS +   E +DYQA C  +    + ++   +   T    + +        +     LF +LL  L    +  A  A A    + +  SC+ K  ++YF   S+N+    I   C NC+   +  R+  +NL+ V  ++  CS  C      Q   +   D GP+ C+L   PRYR  P + C+ +N  E+   C 
Sbjct:  689 REYCKDLNASDNNTEFLKNFIELMEKVTPDSK-QCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEP-FNASFYRRSLDNHGYVFKPPH--QDALLRPLELENDTVGIL-VSTAVELSLGRRTLRP-AVVGVKLD---LEAWAEKFKVLASNRTHQDQPQKQCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAW----SLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYF--GSVNASYNAIID-CGNCSRLFHAQRLTNTNLLFVVAEKPLCS-QCEAGRLLQKETHCPAD-GPEQCELVQRPRYRRGP-HICFDYNATEDTSDCG 1114
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Human
Match: CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:HGNC Symbol;Acc:HGNC:1400])

HSP 1 Score: 284.648 bits (727), Expect = 7.299e-79
Identity = 183/620 (29.52%), Postives = 319/620 (51.45%), Query Frame = 2 
Query:  119 LQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRK-KGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-------FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            L+ E D  MR    V Q   +  IY +   +   E     P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK  + ILN L WT+ L N+F+   R    L +Q F S TG+   YP   WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +    + +    ++   +V ED          +GLGL+ + T+PV+N + +G         LG++G D+ +  +  L P+  LG NGY FAI+ NGY++ HP LK Q    R+P  +D  + E + + K +IR  +I+         G   + +L+K  DE +  E +R Y++  +  + + + +V   Y+ +Y
Sbjct:   77 LEQEVDGVMRIFGGVQQ---LREIYKD--NRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKEAK----QVQWTNVYEDA---------LGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMID------GNKGHKQIRTLVKSLDERYIDEVTRNYTWVPIRSTNYSLGLVLPPYSTFY 648

HSP 2 Score: 94.3597 bits (233), Expect = 9.041e-19
Identity = 105/442 (23.76%), Postives = 190/442 (42.99%), Query Frame = 2 
Query: 2258 RDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEK-VEKFLKRSD----SLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYE--ACNKTR------------------------LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATA---TDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN 3481
            R+   +++  D  T+F    I+++  +   S  +C ++    LI D  + ++ VE+  +  D    SL +V  +T  G++ V P      + +  +   N++ ++R+ D   ++F      QD    P    N++   L V  +  +++    + P AV+G+ L    L +  +K++  A N+T                         LC LI+DGG+++  N      QVG FF ++   +M  L NNS +   E +DYQA C  +    + ++   +   T    + +        +     LF +LL  L    +  A  A A    + +  SC+ K  ++YF   S+N+    I   C NC+   +  R+  +NL+ V  ++  CS  C       +    D GP+ C+L   PRYR  P + C+ +N  E+   C 
Sbjct:  689 REYCKDLNASDNNTEFLKNFIELMEKVTPDSK-QCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEP-FNASFYRRSLDNHGYVFKPPH--QDALLRPLELENDTVGIL-VSTAVELSLGRRTLRP-AVVGVKLD---LEAWAEKFKVLASNRTHQDQPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAW----SLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYF--GSVNASYNAIID-CGNCSRLFHAQRLTNTNLLFVVAEKPLCS-QCEAGRLLQKETHSD-GPEQCELVQRPRYRRGP-HICFDYNATEDTSDCG 1111
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Human
Match: CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:HGNC Symbol;Acc:HGNC:1400])

HSP 1 Score: 284.648 bits (727), Expect = 7.650e-79
Identity = 183/620 (29.52%), Postives = 319/620 (51.45%), Query Frame = 2 
Query:  119 LQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRK-KGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-------FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            L+ E D  MR    V Q   +  IY +   +   E     P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK  + ILN L WT+ L N+F+   R    L +Q F S TG+   YP   WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +    + +    ++   +V ED          +GLGL+ + T+PV+N + +G         LG++G D+ +  +  L P+  LG NGY FAI+ NGY++ HP LK Q    R+P  +D  + E + + K +IR  +I+         G   + +L+K  DE +  E +R Y++  +  + + + +V   Y+ +Y
Sbjct:   77 LEQEVDGVMRIFGGVQQ---LREIYKD--NRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKEAK----QVQWTNVYEDA---------LGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMID------GNKGHKQIRTLVKSLDERYIDEVTRNYTWVPIRSTNYSLGLVLPPYSTFY 648

HSP 2 Score: 93.2041 bits (230), Expect = 2.258e-18
Identity = 106/444 (23.87%), Postives = 191/444 (43.02%), Query Frame = 2 
Query: 2258 RDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEK-VEKFLKRSD----SLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYE--ACNKTR------------------------LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATA---TDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNT--QPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN 3481
            R+   +++  D  T+F    I+++  +   S  +C ++    LI D  + ++ VE+  +  D    SL +V  +T  G++ V P      + +  +   N++ ++R+ D   ++F      QD    P    N++   L V  +  +++    + P AV+G+ L    L +  +K++  A N+T                         LC LI+DGG+++  N      QVG FF ++   +M  L NNS +   E +DYQA C  +    + ++   +   T    + +        +     LF +LL  L    +  A  A A    + +  SC+ K  ++YF   S+N+    I   C NC+   +  R+  +NL+ V  ++  CS  C      Q   +   D GP+ C+L   PRYR  P + C+ +N  E+   C 
Sbjct:  682 REYCKDLNASDNNTEFLKNFIELMEKVTPDSK-QCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEP-FNASFYRRSLDNHGYVFKPPH--QDALLRPLELENDTVGIL-VSTAVELSLGRRTLRP-AVVGVKLD---LEAWAEKFKVLASNRTHQDQPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAW----SLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYF--GSVNASYNAIID-CGNCSRLFHAQRLTNTNLLFVVAEKPLCS-QCEAGRLLQKETHCPAD-GPEQCELVQRPRYRRGP-HICFDYNATEDTSDCG 1106
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Human
Match: CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:HGNC Symbol;Acc:HGNC:1400])

HSP 1 Score: 284.263 bits (726), Expect = 9.135e-79
Identity = 183/620 (29.52%), Postives = 319/620 (51.45%), Query Frame = 2 
Query:  119 LQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRK-KGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-------FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            L+ E D  MR    V Q   +  IY +   +   E     P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK  + ILN L WT+ L N+F+   R    L +Q F S TG+   YP   WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +    + +    ++   +V ED          +GLGL+ + T+PV+N + +G         LG++G D+ +  +  L P+  LG NGY FAI+ NGY++ HP LK Q    R+P  +D  + E + + K +IR  +I+         G   + +L+K  DE +  E +R Y++  +  + + + +V   Y+ +Y
Sbjct:   77 LEQEVDGVMRIFGGVQQ---LREIYKD--NRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKEAK----QVQWTNVYEDA---------LGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMID------GNKGHKQIRTLVKSLDERYIDEVTRNYTWVPIRSTNYSLGLVLPPYSTFY 648

HSP 2 Score: 94.7449 bits (234), Expect = 7.799e-19
Identity = 105/442 (23.76%), Postives = 190/442 (42.99%), Query Frame = 2 
Query: 2258 RDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEK-VEKFLKRSD----SLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYE--ACNKTR------------------------LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATA---TDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN 3481
            R+   +++  D  T+F    I+++  +   S  +C ++    LI D  + ++ VE+  +  D    SL +V  +T  G++ V P      + +  +   N++ ++R+ D   ++F      QD    P    N++   L V  +  +++    + P AV+G+ L    L +  +K++  A N+T                         LC LI+DGG+++  N      QVG FF ++   +M  L NNS +   E +DYQA C  +    + ++   +   T    + +        +     LF +LL  L    +  A  A A    + +  SC+ K  ++YF   S+N+    I   C NC+   +  R+  +NL+ V  ++  CS  C       +    D GP+ C+L   PRYR  P + C+ +N  E+   C 
Sbjct:  682 REYCKDLNASDNNTEFLKNFIELMEKVTPDSK-QCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEP-FNASFYRRSLDNHGYVFKPPH--QDALLRPLELENDTVGIL-VSTAVELSLGRRTLRP-AVVGVKLD---LEAWAEKFKVLASNRTHQDQPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAW----SLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYF--GSVNASYNAIID-CGNCSRLFHAQRLTNTNLLFVVAEKPLCS-QCEAGRLLQKETHSD-GPEQCELVQRPRYRRGP-HICFDYNATEDTSDCG 1104
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Celegans
Match: unc-36 (Voltage-dependent calcium channel unc-36 [Source:UniProtKB/Swiss-Prot;Acc:P34374])

HSP 1 Score: 124.79 bits (312), Expect = 1.491e-28
Identity = 112/482 (23.24%), Postives = 208/482 (43.15%), Query Frame = 2 
Query:  470 SSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRW----RKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFAT--FVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKY----SKTVHYHTIHRENQME--DNEFRIDLVSVNEDGFHNPEDFPPMGLGLM----------------------TSLTMPVYNRSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMR----DPPNVDLTEIEFDSDEKTKIRSK---IINCAASNGTEYGE--DDVISLIK 1777
            S+VHIPT +Y  +  +L  + W+  ++ ++      + +L +Q F S  G +  YP   W    + +  D+FD R  +WY+  A++ K+V++++D SGSM G   ++ K   E +++T+  NDY  +  F   KN  +             C  T   +QA+ RNK  L +++   +++G A  + AL  A +     +N     N GA C  +I++ TD          + + +  N  K +R+F + VG+E    + +    C  RGY  H+  M  V   I  Y    S+ V  H      Q+      +R  L     + F  P         +M                      T+++ PV     N +F+G+   ++ +  + +      +G   Y F ++ NG+++ HP+L+    + +    +  N+DL E+E   ++  +   K   + +    +G  Y E  DD+   ++
Sbjct:  163 SAVHIPTPLYDRNEDLLRKIDWSD-IDAVYRTNREETKDLAFQLFCSEAGYMRYYPAASWFWDNQDEHLDLFDCRNTEWYINSATNSKNVLIMLDMSGSMLGQRYEVAKQTTEAILETLSHNDYFNIMTF--SKNTFL----------LDGCNGTNGLLQATMRNKKALRRKMDTYQSEGKAEYEKALPLAFSVLLDINNGGGDNNRGA-CENVIMLITDGA----PNAYKKIFDMYNADKKVRVFTFLVGDEAIDFNEVREMACNNRGYMVHVANMADVDEKIHHYIRRMSRVVGRH-YKESGQLSWWTGVYRERLYLPRPEIFAEPVPITNQSFAVMNKMASRRKIRLQKSEARSRMFVTTVSYPVI---VNETFMGVAAVNIPLTEVAQKSHPANIGSKSYFFMLDQNGFVMTHPQLRPIDPFTKYHKQNYNNMDLLELEVGQNQNVRSSQKSQAVSDLVCESGANYAECVDDLRKAVR 622
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Celegans
Match: tag-180 (pep chromosome:WBcel235:II:11323051:11329147:-1 gene:WBGene00007041.1 transcript:T24F1.6b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-180)

HSP 1 Score: 109.383 bits (272), Expect = 9.036e-24
Identity = 91/404 (22.52%), Postives = 185/404 (45.79%), Query Frame = 2 
Query:  464 NQSSVHIPTEIYKEDSFILNTLKWT-----QKLNNIFIRASNNLRYQYFASFTGIVLQYPGMRWRKKGT----DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFH-KFD-NRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKN---LRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSG----NGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELK 1621
            ++S +HI  E Y+ D  ++    WT     +K  +     +  + +QY  +++G+   YP   W+ + T    D+FD R R W+V   S PKD++ L+D SGS+ G  + L K  +  ++ T+  NDY    +F    N         P I       TF+ A+  NK   F+++  L  +  A+  T L+F+++      D N++   +  +  ++L+++FTD  DE+  +    +++    T+N   +RIF + +G   + + + +   C+  G +  I ++  V       S+T+     +  +Q+  +E +       E  +         G G + +L++P+         +    G++  D+++    + +P        Y + ++ NG +I+HP+L+
Sbjct:  142 SKSGIHITVESYQCDPRVMRDFDWTGTKHLEKTMSDNKEKAPEMGHQYIGTYSGLTRMYPRRHWKVEPTPITIDLFDPRFRPWFVNAESVPKDIVFLLDYSGSVKGPTMHLIKITMMYILSTLSPNDYFFGVYFNNHFN---------PIISCAN--RTFMPATTSNKKVFFEELGMLEEKDQAHFATPLKFSLDVLRGNLDSNQSLFADYRSEGHKLLIIFTDGVDEWPHQ----ILDEEFQTRNSELIRIFGFSMGYGTSLLPLQQYMACKSHGGYSEIDSIMDVK----PQSRTIQ----NVLSQVRGDELKGTNAEKREPSWTQLY-METQGTGPIVTLSLPILTSEQRIWRDQKLAGVVAIDISIKEFTKHLPTS--SEQMYGYIVDNNGMLIYHPQLQ 519
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Celegans
Match: tag-180 (pep chromosome:WBcel235:II:11323051:11329429:-1 gene:WBGene00007041.1 transcript:T24F1.6a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-180)

HSP 1 Score: 109.383 bits (272), Expect = 9.191e-24
Identity = 91/404 (22.52%), Postives = 185/404 (45.79%), Query Frame = 2 
Query:  464 NQSSVHIPTEIYKEDSFILNTLKWT-----QKLNNIFIRASNNLRYQYFASFTGIVLQYPGMRWRKKGT----DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFH-KFD-NRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKN---LRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSG----NGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELK 1621
            ++S +HI  E Y+ D  ++    WT     +K  +     +  + +QY  +++G+   YP   W+ + T    D+FD R R W+V   S PKD++ L+D SGS+ G  + L K  +  ++ T+  NDY    +F    N         P I       TF+ A+  NK   F+++  L  +  A+  T L+F+++      D N++   +  +  ++L+++FTD  DE+  +    +++    T+N   +RIF + +G   + + + +   C+  G +  I ++  V       S+T+     +  +Q+  +E +       E  +         G G + +L++P+         +    G++  D+++    + +P        Y + ++ NG +I+HP+L+
Sbjct:  142 SKSGIHITVESYQCDPRVMRDFDWTGTKHLEKTMSDNKEKAPEMGHQYIGTYSGLTRMYPRRHWKVEPTPITIDLFDPRFRPWFVNAESVPKDIVFLLDYSGSVKGPTMHLIKITMMYILSTLSPNDYFFGVYFNNHFN---------PIISCAN--RTFMPATTSNKKVFFEELGMLEEKDQAHFATPLKFSLDVLRGNLDSNQSLFADYRSEGHKLLIIFTDGVDEWPHQ----ILDEEFQTRNSELIRIFGFSMGYGTSLLPLQQYMACKSHGGYSEIDSIMDVK----PQSRTIQ----NVLSQVRGDELKGTNAEKREPSWTQLY-METQGTGPIVTLSLPILTSEQRIWRDQKLAGVVAIDISIKEFTKHLPTS--SEQMYGYIVDNNGMLIYHPQLQ 519
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Celegans
Match: unc-36 (Voltage-dependent calcium channel unc-36 [Source:UniProtKB/Swiss-Prot;Acc:P34374])

HSP 1 Score: 108.227 bits (269), Expect = 1.974e-23
Identity = 100/465 (21.51%), Postives = 185/465 (39.78%), Query Frame = 2 
Query:  470 SSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRW----RKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFAT--FVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEF------HKFDNRTEKGNEGAN-------------------------------------CNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKY----SKTVHYHTIHREN---QMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLM----------------------TSLTMPVYNRSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELK 1621
            S+VHIPT +Y  +  +L  + W+  ++ ++      + +L +Q F S  G +  YP   W    + +  D+FD R  +WY+  A++ K+V++++D SGSM G   ++ K   E +++T+  NDY  +  F   KN  +             C  T   +QA+ RNK  L +++   +++G A  + AL  A +        +    + E     AN                                     C  +I++ TD          + + +  N  K +R+F + VG+E    + +    C  RGY  H+  M  V   I  Y    S+ V  H  ++E+         +R  L     + F  P         +M                      T+++ PV     N +F+G+   ++ +  + +      +G   Y F ++ NG+++ HP+L+
Sbjct:  163 SAVHIPTPLYDRNEDLLRKIDWSD-IDAVYRTNREETKDLAFQLFCSEAGYMRYYPAASWFWDNQDEHLDLFDCRNTEWYINSATNSKNVLIMLDMSGSMLGQRYEVAKQTTEAILETLSHNDYFNIMTF--SKNTFL----------LDGCNGTNGLLQATMRNKKALRRKMDTYQSEGKAEYEKALPLAFSVLLDLKGSYALYTKEEMSMMSANATNEYQFHLELPEHVLAATKQYIDSINNGGGDNNRGACENVIMLITDGA----PNAYKKIFDMYNADKKVRVFTFLVGDEAIDFNEVREMACNNRGYMVHVANMADVDEKIHHYIRRMSRVVGRH--YKESGQLSWWTGVYRERLYLPRPEIFAEPVPITNQSFAVMNKMASRRKIRLQKSEARSRMFVTTVSYPVI---VNETFMGVAAVNIPLTEVAQKSHPANIGSKSYFFMLDQNGFVMTHPQLR 605
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Fly
Match: stj (gene:FBgn0261041 transcript:FBtr0087631)

HSP 1 Score: 197.593 bits (501), Expect = 5.781e-51
Identity = 151/546 (27.66%), Postives = 251/546 (45.97%), Query Frame = 2 
Query:  470 SSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASNN---LRYQYFASFTGIVLQYPGMRWRKK-GTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFA-TFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTV--------HYHTIHREN---QMEDNEFRIDLVSVNE---------------DGFHNPEDF-------------PPMGLGL---MTSLTMPVYNRSGNGS----FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQL-GWMRDPP--NVDLTEIEFDSDEKTK---------IRSKIINCAASNGTEYGEDDVISLIKVS-DEIHTYEK-SRTYSYTGVPYSTFGITIVNSKYNKYYPVFSQDIK 1912
            SSVH+P  ++     ++  ++W++ L+ IF     N   L +Q+F S TG + Q+P  +WRK    D++D R R WY++ A+SPKD+++L+D SGSM G  + + K  V  ++DT+G ND++ +  F            D       PCF  T +QA+  N   L + I   R + IAN   AL  A     +    T+  + GA CN+ I++  D   E ++E       R    K +R+F Y +G+E+   D +    CE +GY+ H+     V  ++  Y   +        H H +        +ED +    L  +N+               D    P +               P+   +   MT+++MP+Y+R  N +     LG+ GTD+ +  + +L+    LG NGYAF +  NGY++FHP+ +    G++  P   +VD+ E+E   D++           IR  IIN   S G+++       L+K   DE+    +  R Y +T +  + F + I    Y + Y V   DI+
Sbjct:  182 SSVHVPVNVFDRAPDVIKAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASKWRKDVPVDLYDCRLRSWYMEAATSPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTF------------DKEVSPVVPCFEDTLIQANLGNIRELKEGIELFRPKSIANYTAALTKAFELLEE----TKLSSRGAQCNQAIMIIGDGAPENNREVFELHNWRDPPYKPVRVFTYLIGKEVANWDDIRWMACENQGYYVHLSDTAEVREMVLNYIPVMARPLVLGRHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEYWQVHDRMLEPSEMHRRKYRRMKETWNQPVDSNVYQFMTTVSMPIYDRRENATRIANILGVAGTDVPINEIKKLLSPFTLGVNGYAFIVTNNGYVLFHPDFRPIFQGYILKPAYNSVDMIEVELLDDDRPARDFNPVLMTIRDSIIN--QSTGSKW------MLVKNHFDEMKRVARVKRQYYWTAIKKTPFTLVI---SYPEQYGVSHMDIR 700

HSP 2 Score: 53.9138 bits (128), Expect = 9.926e-7
Identity = 26/93 (27.96%), Postives = 51/93 (54.84%), Query Frame = 2 
Query: 2708 PIAVLGLSLKQLPLVSIMQKY--EACN-KTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDE 2977
            P AV+G   +   L  +       AC    + CY++++ GYVI       +H+ G FFG+++  +M  L+  ++++ +  +DYQA+C + K++
Sbjct:  909 PAAVVGFQFQHSALYKLFHNITGNACAVDDKDCYILDNNGYVII---STRVHETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKND 998
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Fly
Match: Ca-Ma2d (gene:FBgn0261999 transcript:FBtr0303797)

HSP 1 Score: 191.43 bits (485), Expect = 5.181e-49
Identity = 131/463 (28.29%), Postives = 224/463 (48.38%), Query Frame = 2 
Query:  365 IKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIF---IRASNNLRYQYFASFTGIVLQYPGMRW-----RKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF-ATFVQASKRNKDRLFKQIFQL-RAQGIANLDTALEFAINEFHK-FDNRTEKGNEGANCNRLIVVFTD--SGDEYDKEKIRSLMNRSNTTKNL--RIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNR--------SGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPN---VDLTEIE 1675
            ++P E ++     +  N EL  D   + T V    SSVH+P+ I+     +L T+ W++ L+ +F    ++   L +QYF S TGI+  YP  +W      +   D +D R+R WY++ A+  KD+++L+D SGSM G    + K  +  ++DT   ND+  +  +    N  +            PCF    VQA+  N +   +QI QL   +G ANL  A E A     K +D+R    N  + CN+ I++ TD  +G+  +  +  +  N  N T  +  R+F Y +G+E+T +  ++   C  RGY+ H+  +  V   + KY   +    +     +++ +          D  ++P+        LM S+ +P ++R        +     LG+ GTD+ V  +D+L    KLG NGY+F ++ NGY++ HP+L+      +  PN   +D TE+E
Sbjct:  160 LEPNEAEFAW---MYRNMELNPDTHFYNTPVDTEHSSVHVPSNIWDRSERVLKTIMWSEHLDEVFRQNYQSDPALSWQYFGSDTGILRHYPAAQWTDTRPNRDDADTYDCRKRSWYIETATCSKDIVILLDHSGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVNDII------------PCFNGALVQATPENIEVFNQQIEQLDDPEGYANLTLAYETAFQLLRKYYDSRHCVTN--STCNQAIMLVTDGVAGNTTEVFQKYNWGNGENGTSQMDTRVFTYLLGKEVTKVREIQWMACLNRGYYSHVQTLDEVHEEVLKYVDVIATPLV-----LQNEQHPPTWTHAFTDKTYDPKTSNEKRPRLMISVGVPAFDRFYRHANSTNPRARLLGVAGTDVPVEDIDKLTLPYKLGVNGYSFVVSNNGYVLLHPDLRPIGTNGKMNPNYNSIDFTEVE 600
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Fly
Match: Ca-Ma2d (gene:FBgn0261999 transcript:FBtr0332356)

HSP 1 Score: 191.43 bits (485), Expect = 5.181e-49
Identity = 131/463 (28.29%), Postives = 224/463 (48.38%), Query Frame = 2 
Query:  365 IKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIF---IRASNNLRYQYFASFTGIVLQYPGMRW-----RKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF-ATFVQASKRNKDRLFKQIFQL-RAQGIANLDTALEFAINEFHK-FDNRTEKGNEGANCNRLIVVFTD--SGDEYDKEKIRSLMNRSNTTKNL--RIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNR--------SGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPN---VDLTEIE 1675
            ++P E ++     +  N EL  D   + T V    SSVH+P+ I+     +L T+ W++ L+ +F    ++   L +QYF S TGI+  YP  +W      +   D +D R+R WY++ A+  KD+++L+D SGSM G    + K  +  ++DT   ND+  +  +    N  +            PCF    VQA+  N +   +QI QL   +G ANL  A E A     K +D+R    N  + CN+ I++ TD  +G+  +  +  +  N  N T  +  R+F Y +G+E+T +  ++   C  RGY+ H+  +  V   + KY   +    +     +++ +          D  ++P+        LM S+ +P ++R        +     LG+ GTD+ V  +D+L    KLG NGY+F ++ NGY++ HP+L+      +  PN   +D TE+E
Sbjct:  160 LEPNEAEFAW---MYRNMELNPDTHFYNTPVDTEHSSVHVPSNIWDRSERVLKTIMWSEHLDEVFRQNYQSDPALSWQYFGSDTGILRHYPAAQWTDTRPNRDDADTYDCRKRSWYIETATCSKDIVILLDHSGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVNDII------------PCFNGALVQATPENIEVFNQQIEQLDDPEGYANLTLAYETAFQLLRKYYDSRHCVTN--STCNQAIMLVTDGVAGNTTEVFQKYNWGNGENGTSQMDTRVFTYLLGKEVTKVREIQWMACLNRGYYSHVQTLDEVHEEVLKYVDVIATPLV-----LQNEQHPPTWTHAFTDKTYDPKTSNEKRPRLMISVGVPAFDRFYRHANSTNPRARLLGVAGTDVPVEDIDKLTLPYKLGVNGYSFVVSNNGYVLLHPDLRPIGTNGKMNPNYNSIDFTEVE 600
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Fly
Match: stj (gene:FBgn0261041 transcript:FBtr0304694)

HSP 1 Score: 190.66 bits (483), Expect = 9.125e-49
Identity = 151/564 (26.77%), Postives = 251/564 (44.50%), Query Frame = 2 
Query:  470 SSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASNN---LRYQYFASFTGIVLQYPGMRWRKK-GTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFA-TFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTV--------HYHTIHREN---QMEDNEFRIDLVSVNE---------------DGFHNPEDF-------------PPMGLGL---MTSLTMPVYNRSGN----------------------GSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQL-GWMRDPP--NVDLTEIEFDSDEKTK---------IRSKIINCAASNGTEYGEDDVISLIKVS-DEIHTYEK-SRTYSYTGVPYSTFGITIVNSKYNKYYPVFSQDIK 1912
            SSVH+P  ++     ++  ++W++ L+ IF     N   L +Q+F S TG + Q+P  +WRK    D++D R R WY++ A+SPKD+++L+D SGSM G  + + K  V  ++DT+G ND++ +  F            D       PCF  T +QA+  N   L + I   R + IAN   AL  A     +    T+  + GA CN+ I++  D   E ++E       R    K +R+F Y +G+E+   D +    CE +GY+ H+     V  ++  Y   +        H H +        +ED +    L  +N+               D    P +               P+   +   MT+++MP+Y+R  N                       + LG+ GTD+ +  + +L+    LG NGYAF +  NGY++FHP+ +    G++  P   +VD+ E+E   D++           IR  IIN   S G+++       L+K   DE+    +  R Y +T +  + F + I    Y + Y V   DI+
Sbjct:  182 SSVHVPVNVFDRAPDVIKAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASKWRKDVPVDLYDCRLRSWYMEAATSPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTF------------DKEVSPVVPCFEDTLIQANLGNIRELKEGIELFRPKSIANYTAALTKAFELLEE----TKLSSRGAQCNQAIMIIGDGAPENNREVFELHNWRDPPYKPVRVFTYLIGKEVANWDDIRWMACENQGYYVHLSDTAEVREMVLNYIPVMARPLVLGRHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEYWQVHDRMLEPSEMHRRKYRRMKETWNQPVDSNVYQFMTTVSMPIYDRRENALINLTTDINPAAKINLQVTRIANILGVAGTDVPINEIKKLLSPFTLGVNGYAFIVTNNGYVLFHPDFRPIFQGYILKPAYNSVDMIEVELLDDDRPARDFNPVLMTIRDSIIN--QSTGSKW------MLVKNHFDEMKRVARVKRQYYWTAIKKTPFTLVI---SYPEQYGVSHMDIR 718

HSP 2 Score: 53.9138 bits (128), Expect = 1.027e-6
Identity = 26/93 (27.96%), Postives = 51/93 (54.84%), Query Frame = 2 
Query: 2708 PIAVLGLSLKQLPLVSIMQKY--EACN-KTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDE 2977
            P AV+G   +   L  +       AC    + CY++++ GYVI       +H+ G FFG+++  +M  L+  ++++ +  +DYQA+C + K++
Sbjct:  962 PAAVVGFQFQHSALYKLFHNITGNACAVDDKDCYILDNNGYVII---STRVHETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKND 1051
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Fly
Match: stj (gene:FBgn0261041 transcript:FBtr0304695)

HSP 1 Score: 189.889 bits (481), Expect = 1.453e-48
Identity = 151/565 (26.73%), Postives = 251/565 (44.42%), Query Frame = 2 
Query:  470 SSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASNN---LRYQYFASFTGIVLQYPGMRWRKK-GTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFA-TFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTV--------HYHTIHREN---QMEDNEFRIDLVSVNE---------------DGFHNPEDF-------------PPMGLGL---MTSLTMPVYNRSGN-----------------------GSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQL-GWMRDPP--NVDLTEIEFDSDEKTK---------IRSKIINCAASNGTEYGEDDVISLIKVS-DEIHTYEK-SRTYSYTGVPYSTFGITIVNSKYNKYYPVFSQDIK 1912
            SSVH+P  ++     ++  ++W++ L+ IF     N   L +Q+F S TG + Q+P  +WRK    D++D R R WY++ A+SPKD+++L+D SGSM G  + + K  V  ++DT+G ND++ +  F            D       PCF  T +QA+  N   L + I   R + IAN   AL  A     +    T+  + GA CN+ I++  D   E ++E       R    K +R+F Y +G+E+   D +    CE +GY+ H+     V  ++  Y   +        H H +        +ED +    L  +N+               D    P +               P+   +   MT+++MP+Y+R  N                        + LG+ GTD+ +  + +L+    LG NGYAF +  NGY++FHP+ +    G++  P   +VD+ E+E   D++           IR  IIN   S G+++       L+K   DE+    +  R Y +T +  + F + I    Y + Y V   DI+
Sbjct:  182 SSVHVPVNVFDRAPDVIKAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASKWRKDVPVDLYDCRLRSWYMEAATSPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTF------------DKEVSPVVPCFEDTLIQANLGNIRELKEGIELFRPKSIANYTAALTKAFELLEE----TKLSSRGAQCNQAIMIIGDGAPENNREVFELHNWRDPPYKPVRVFTYLIGKEVANWDDIRWMACENQGYYVHLSDTAEVREMVLNYIPVMARPLVLGRHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEYWQVHDRMLEPSEMHRRKYRRMKETWNQPVDSNVYQFMTTVSMPIYDRRENANITEEVLINEALWELQTRETRIANILGVAGTDVPINEIKKLLSPFTLGVNGYAFIVTNNGYVLFHPDFRPIFQGYILKPAYNSVDMIEVELLDDDRPARDFNPVLMTIRDSIIN--QSTGSKW------MLVKNHFDEMKRVARVKRQYYWTAIKKTPFTLVI---SYPEQYGVSHMDIR 719

HSP 2 Score: 54.299 bits (129), Expect = 9.465e-7
Identity = 26/93 (27.96%), Postives = 51/93 (54.84%), Query Frame = 2 
Query: 2708 PIAVLGLSLKQLPLVSIMQKY--EACN-KTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDE 2977
            P AV+G   +   L  +       AC    + CY++++ GYVI       +H+ G FFG+++  +M  L+  ++++ +  +DYQA+C + K++
Sbjct:  928 PAAVVGFQFQHSALYKLFHNITGNACAVDDKDCYILDNNGYVII---STRVHETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKND 1017
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Zebrafish
Match: cacna2d2b (calcium channel, voltage-dependent, alpha 2/delta subunit 2b [Source:ZFIN;Acc:ZDB-GENE-060503-99])

HSP 1 Score: 276.944 bits (707), Expect = 8.275e-77
Identity = 177/573 (30.89%), Postives = 299/573 (52.18%), Query Frame = 2 
Query:  236 NPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK--------DLPENSELLVD---HPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASNN---LRYQYFASFTGIVLQYPGMRWRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-----FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTY--EKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            NP +I +  +  +     KK ++L+R    AE    ++++   IK E ++Y NSK        D+     L +D    P FK +V  + ++V IPT+IYK    ILN L WTQ L  +FI  S +   L +Q F S TG+   YP   WR     D++DVRRR WY+QGASSPKD+++L+D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  + +         PCF   VQA+ RNK    + + Q++A+G  +  +   FA N+     N        ANCN++I++FTD G++  ++ I    N  N  K +R+F + VG+    +  L+   C  +GY+  I ++ A+     +Y   +    +      +    ++   +V +D          +GLGL+ + TMPV+N + NG       LG++G D+ +  +  L P  KLG NGY FAI+ NGY++ HP L+ +   + +   +D  + E +   K +IR ++I+  + + T      + +LIK  DE   Y  + +R Y++T +  + + + +V   Y+++Y
Sbjct:   40 NPRDIVEKVATDIERLLAKKRKALERLASEAERLQKEHRWQDGIKEENIEYYNSKAEMDYDGEDIDSQMSLKLDFVYDPSFKNQVNYSHTAVQIPTDIYKGAPVILNELNWTQALERVFIENSRDDPSLLWQAFGSATGVTRYYPAAPWRAPDKIDLYDVRRRPWYIQGASSPKDMVILVDVSGSVSGLTLKLIKASVTEMLDTLSDDDYVNVARF----NEKAEAV--------VPCFDHLVQANVRNKKIFKEAVQQMQAKGTTDYKSGFHFAFNQLLNKTNVPR-----ANCNKIIMLFTDGGEDRAQD-IFEQYNWPN--KTVRVFTFSVGQHNYDVTPLQWIACSNKGYYFEIRSICAIRINTQEYLDVLGRPMVLAGRIAK----QVQWTNVYQDA---------LGLGLVVTGTMPVFNLTVNGDSQNQLILGVMGVDVHLDELKRLTPQYKLGANGYIFAIDPNGYVLMHPNLQPREEDLPEQVTLDFLDAEVEDSSKQEIRRQMIDGRSGDMT------IKTLIKSMDEASRYIDDVTRMYTWTPINDTDYSLGLVLPPYSEHY 573

HSP 2 Score: 103.605 bits (257), Expect = 8.002e-22
Identity = 111/446 (24.89%), Postives = 185/446 (41.48%), Query Frame = 2 
Query: 2297 TKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEKVEKFLKRSDSLT-----SVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFY--TLFNIQDLQKEPDNSNNNSFPDLKVFKSF-SVTMKPDHVIPIAVLGLSLKQLPLVSIM-----------QKYEACNKTR-------------LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQE-----------------ATATDNK-NISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNS 3484
            T+F V+ + ++  +   S+D C       LI D  +L ++   + ++  L      ++  ST  G++ V P      + +  +  LNS  ++R+ D + +IF   T  ++ DL    +N          V  +F S TMKP      AV+G+ L     V              Q    C  +R             LCYLI+DGG+++  N +    +VG FFG++ P +M  L NNSI+   + F YQ+ C         ++                      FY+ +I  F+ L    +   +S  Q+                 A + D+K + SC+  Y +FYF  ++ NS    + Q C NC+   +  R+  +NL+ V  +   CS+       P R   ++  P  C + N  RYR  P  KC+ +N +EN  +C S
Sbjct:  620 TQFLVDFLSLMVEISPESED-CDQGLIHNLILDSGILWQLATRVWQNKDLGTYGFLALFASTNGGVTRVYPNMAAESWDEDPEP-LNSNFYRRSLDNKGYIFRAPTRTSMDDLLIS-ENGTVGILVTTAVEVAFGSKTMKP------AVVGVKLDLEAWVDKFKILASNVSDSRQAAHKCGPSRSCEMDCEVNSDDLLCYLIDDGGFLVMSNQRDHWKKVGLFFGEVDPYLMFALYNNSIYSRHQTFQYQSACEPTASSHTGAAHRG-------------------FYVPSIADFLSLAWWTSAAAWSILQQFLYGVMYSSWFTTADVWAESADSKGSSSCVTVYSQFYFTNTT-NSF--NVLQDCGNCSRLFHAKRIENTNLLFVVAETLPCSSCEIEKLLPVRTKSQEENP--CDVLNSARYRKGPD-KCFDYNSEENTSQCGS 1031
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Zebrafish
Match: cacna2d2b (calcium channel, voltage-dependent, alpha 2/delta subunit 2b [Source:ZFIN;Acc:ZDB-GENE-060503-99])

HSP 1 Score: 268.085 bits (684), Expect = 6.123e-74
Identity = 172/565 (30.44%), Postives = 294/565 (52.04%), Query Frame = 2 
Query:  236 NPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVD---HPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASNN---LRYQYFASFTGIVLQYPGMRWRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-----FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTY--EKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            NP +I +  +  +     KK ++L+R    AE    ++++   IK       + +D+     L +D    P FK +V  + ++V IPT+IYK    ILN L WTQ L  +FI  S +   L +Q F S TG+   YP   WR     D++DVRRR WY+QGASSPKD+++L+D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  + +         PCF   VQA+ RNK    + + Q++A+G  +  +   FA N+     N        ANCN++I++FTD G++  ++ I    N  N  K +R+F + VG+    +  L+   C  +GY+  I ++ A+     +Y   +    +      +    ++   +V +D          +GLGL+ + TMPV+N + NG       LG++G D+ +  +  L P  KLG NGY FAI+ NGY++ HP L+ +   + +   +D  + E +   K +IR ++I+  + + T      + +LIK  DE   Y  + +R Y++T +  + + + +V   Y+++Y
Sbjct:   41 NPRDIVEKVATDIERLLAKKRKALERLASEAERLQKEHRWQDGIK-------DGEDIDSQMSLKLDFVYDPSFKNQVNYSHTAVQIPTDIYKGAPVILNELNWTQALERVFIENSRDDPSLLWQAFGSATGVTRYYPAAPWRAPDKIDLYDVRRRPWYIQGASSPKDMVILVDVSGSVSGLTLKLIKASVTEMLDTLSDDDYVNVARF----NEKAEAV--------VPCFDHLVQANVRNKKIFKEAVQQMQAKGTTDYKSGFHFAFNQLLNKTNVPR-----ANCNKIIMLFTDGGEDRAQD-IFEQYNWPN--KTVRVFTFSVGQHNYDVTPLQWIACSNKGYYFEIRSICAIRINTQEYLDVLGRPMVLAGRIAK----QVQWTNVYQDA---------LGLGLVVTGTMPVFNLTVNGDSQNQLILGVMGVDVHLDELKRLTPQYKLGANGYIFAIDPNGYVLMHPNLQPREEDLPEQVTLDFLDAEVEDSSKQEIRRQMIDGRSGDMT------IKTLIKSMDEASRYIDDVTRMYTWTPINDTDYSLGLVLPPYSEHY 559

HSP 2 Score: 97.0561 bits (240), Expect = 7.716e-20
Identity = 114/457 (24.95%), Postives = 187/457 (40.92%), Query Frame = 2 
Query: 2297 TKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEKVEKFLKRSDSLT-----SVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFY--TLFNIQDLQKEPDNSNNNSFPDLKVFKSF-SVTMKPDHVIPIAVLGLSLKQLPLVSIM-----------QKYEACNKTR-------------LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQE-----------------ATATDNK-NISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVT-----------RMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNS 3484
            T+F V+ + ++  +   S+D C       LI D  +L ++   + ++  L      ++  ST  G++ V P      + +  +  LNS  ++R+ D + +IF   T  ++ DL    +N          V  +F S TMKP      AV+G+ L     V              Q    C  +R             LCYLI+DGG+++  N +    +VG FFG++ P +M  L NNSI+   + F YQ+ C         ++                      FY+ +I  F+ L    +   +S  Q+                 A + D+K + SC+  Y +FYF  ++ NS    + Q C NC+ SI  T           R+  +NL+ V  +   CS+       P R   ++  P  C + N  RYR  P  KC+ +N +EN  +C S
Sbjct:  606 TQFLVDFLSLMVEISPESED-CDQGLIHNLILDSGILWQLATRVWQNKDLGTYGFLALFASTNGGVTRVYPNMAAESWDEDPEP-LNSNFYRRSLDNKGYIFRAPTRTSMDDLLIS-ENGTVGILVTTAVEVAFGSKTMKP------AVVGVKLDLEAWVDKFKILASNVSDSRQAAHKCGPSRSCEMDCEVNSDDLLCYLIDDGGFLVMSNQRDHWKKVGLFFGEVDPYLMFALYNNSIYSRHQTFQYQSACEPTASSHTGAAHRG-------------------FYVPSIADFLSLAWWTSAAAWSILQQFLYGVMYSSWFTTADVWAESADSKGSSSCVTVYSQFYFTNTT-NSF--NVLQDCGNCS-SILTTNSLSVRLFHAKRIENTNLLFVVAETLPCSSCEIEKLLPVRTKSQEENP--CDVLNSARYRKGPD-KCFDYNSEENTSQCGS 1027
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Zebrafish
Match: CACNA2D1 (si:dkey-266j7.2 [Source:ZFIN;Acc:ZDB-GENE-060503-162])

HSP 1 Score: 250.366 bits (638), Expect = 4.493e-68
Identity = 166/579 (28.67%), Postives = 292/579 (50.43%), Query Frame = 2 
Query:  236 NPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSEL----------LVDHPLFKTRVIA-NQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASN---NLRYQYFASFTGIVLQYPGMRW---RKKGT--DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYN---------RSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            N +++ +  +  + N  +K+  +L+     AE    ++Q+      +++ Y N+KD  E ++             + P FK R+ + N ++VHIPT+IY   + +LN L WT+ L ++F +       L +Q F S TG+   YP   W   RK  +  D++DVRRR WYVQGA+SPKD+++L+D SGS+ G+ +KL +++V ++++T+ ++DY+ V HF    N                CF   VQA+ RNK  L   +  + A+GI N     EFA N+       +      ANCN++I++FTD G+E  +E    + +R N  + +R+F + VG+       ++   C+ +GYF  I ++GA+     + +   +   + R   + D + ++   +V  D            LGL+ + T+PV+N         RS N   LG++G D+++  +  L P   +G NGY FAI+ NGY++ HP L+ ++     P    + +   D      IR+ +IN ++      GE  + +L+K  DE +     R Y++  V  + + + +V  +Y+ +Y
Sbjct:   60 NAVQLVETAARNIENFLKKRATALETLATAAENFQMEHQWKDEFA-DDIVYFNAKDNLETNDTEGRKNRIRPEFKEDPSFKNRLTSYNHTAVHIPTDIYDGSTIVLNELNWTEALEDVFKKNREEDPTLLWQVFGSATGLARFYPASPWMDARKTPSKIDLYDVRRRPWYVQGAASPKDMLILVDASGSVSGLTLKLIRTSVSEMLETLSDDDYVNVVHFNTKVNNTA-------------CFDHLVQANVRNKKILKDAVQNITAKGITNYTKGFEFAFNQL------SNPNISRANCNKIIMLFTDGGEERAEE----IFSRHNIDRKVRVFTFSVGQHNYDTGPIKWMACQNKGYFYEIPSIGAI-----RINTQEYLDVLGRPMVLADAK-QVQWTNVYLDALE---------LGLVITGTLPVFNKTKSTEARSRSQNQLILGVMGVDVSLDDIKRLTPRFTIGPNGYYFAIDPNGYVLLHPNLQPKV-----PKTPRVHQDYLD------IRTMMINNSS------GEKTIETLVKSQDERYIDRGIRKYTWAPVNGTDYSLALVLPEYSLHY 582

HSP 2 Score: 98.2117 bits (243), Expect = 4.135e-20
Identity = 87/401 (21.70%), Postives = 184/401 (45.89%), Query Frame = 2 
Query: 2297 TKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEKVEKFLKRS--DSLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHV-IPIAVLGLSLKQLPLVSIMQKYEACNKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYF-NESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDP-GPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNS 3484
            T+F ++  + +N  Q  +D  C +    R++ D  +  K+ K  K    D + +  ++T  G++ V PKS    + +  + + +S+ ++R+ D + +IF   +          N +  S  +  +  S +V +  D   +  AV+G+ L     ++             C +++DGG+++  N ++ + Q+G FFG++ P++M  L+N S++   + +DYQ++C  E++ +              + +P +     + +  +  + +R++       +S    + A   +  SCI +  +++F NE+   S   +    C NC+      ++  +NL+ +  D      +C  +T+P +   +   GPD C L+ +PRYR  P   C+  N DE+   C  
Sbjct:  632 TQFLMDFNEYINK-QTPNDPTCNYTLVNRMLLDAGLTAKLIKVWKEQSVDGVLARFVATDGGITRVYPKSAGEEWGENSETY-DSSFYKRSLDNDIYIFTAPYV---------NKSRESGYESGILVSKAVDLDIDGAKLKPAVVGVKLNVSAWMNSFINATTKKNQVDCVILDDGGFLLMSNQEEYIQQIGQFFGEVDPVLMITLVNTSLYSFNKTYDYQSVCDPERETK-------AAAGHRAIYVPTIADLLTVGWWASTAVCMRMVCVCVFPVYSEDDLSDAFSKE--SCITEQTQYFFENENKSFSGAMD----CGNCSRMYRAEKLPNTNLVFLISDAKISCMSC--DTKPLKQAEQPSNGPDPCVLAQKPRYRKGPDV-CFDNNADEDASDCGG 1005
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Zebrafish
Match: cacna2d1a (calcium channel, voltage-dependent, alpha 2/delta subunit 1a [Source:ZFIN;Acc:ZDB-GENE-041210-215])

HSP 1 Score: 246.514 bits (628), Expect = 1.098e-66
Identity = 155/543 (28.55%), Postives = 275/543 (50.64%), Query Frame = 2 
Query:  344 KYQYDPHIKPEEVQYINSKDL------PENSELLVD---HPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASNN---LRYQYFASFTGIVLQYPGMRW--RKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-----------FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVI---SLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            ++Q+   +   E  Y N+KD       P  + L++D    P FK  V  N ++VHIPT+IY+  + ILN L WT  L+++F +   +   L +Q F S TG+   +P   W   K   D++DVRRR WY+QGA+SPKD+++L+D SGS+ G+ +KL +++V ++++T+ ++DY+ +  F    N A          ++  CF   VQA+ RNK  L + + ++ A G  +     + A N+    +         ANCN++I++FTD G+    +K   + +  N+ K +RIF + VG+       ++   C  +GY+  I ++GA+     +Y   +    +  + + ++    +   +V  D            LGL+ + T+PV+N++                LG++  D+++  +  L PH  LG NGY FAI+ NGY++ HP L+ +    ++P  +D  + E + + K  IR  +I+         GE   I   +L+K  DE +  +  RTY+++ V  + + + +V   Y+  Y
Sbjct:  114 EHQWKEDLDVNETIYYNAKDKSDNQTEPRKNRLILDFTEDPAFKRPVSYNTTAVHIPTDIYEGSTIILNELNWTAALDDVFRKNKEDDPSLHWQVFGSATGLARYFPASPWVDSKNKIDLYDVRRRPWYIQGAASPKDMLILVDASGSVSGLTLKLIRTSVSEMLETLSDDDYVNIVSF---NNSA----------KSVACFENLVQANVRNKKTLKEAVQKITANGTTDYKIGFKEAFNQLASMNVSR------ANCNKIIMLFTDGGE----DKASEIFDEYNSDKRVRIFTFSVGQHNYDKAPIQYMACHNKGYYYEIPSIGAIRINTQEYLDVLGRPMVKADKKAKN----VQWTNVYVDALE---------LGLVVTGTLPVFNKTRTSKEKPKNLGPSQMILGVMAIDVSLDDIKRLTPHYTLGPNGYYFAIDPNGYVLLHPNLQPKDLKSQEPVTLDFLDAEMEDEVKVDIRRSMID---------GERSQIRFHTLMKSQDERYIDKGFRTYTWSPVTDADYSLALVLPDYSMSY 611

HSP 2 Score: 99.7525 bits (247), Expect = 1.252e-20
Identity = 96/421 (22.80%), Postives = 186/421 (44.18%), Query Frame = 2 
Query: 2279 SNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEKVEKFLKR---SDSLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHV-IPIAVLGLSLK-QLPLVSIMQ-------KYEACNKTR-----LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFY--LENIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNS 3484
            +  + +T+F ++  + ++ ++  +D +C      RL+ D  +  ++ K   +   SD + +  ++T  G++ V P S    +    + +  S+ ++R+ D + ++F  L         P   N     +  V  S ++ ++ D   +  AV+G+ L  Q  + S M        + E C   R      C L++DGG+++  N  K + Q+G FFG I P +M  L+N S+F     +DYQA+C   ++ + ++    +   T    + +        +  ++ +F+ I     L  +  S   E  + +    SCIK+  +++F+    N    + T  C+NC+      ++  +NL+++  D   CS                PGPD C +S  PRYR  P  +C+  N +EN   C  
Sbjct:  653 AQNENMTQFLIDFNEYID-VKTPNDPQCNMDLMNRLLLDAGITAELVKHWNKNQLSDRIKAKFVATDGGVTRVYPASAGSEWTGQAETY-ESSFYKRSLDNDLYVFTPL---------PFTGNKT---EESVLVSRAMDLRIDEFWLKPAVVGVKLDVQSWMESFMNTTITPKCEGEICGCRRNDEYLDCVLLDDGGFLVMANQDKYIDQIGEFFGMIDPSLMRNLMNVSLFSVNITYDYQALCEPTRESKAAAGLRSVYVPTIADILNIGWWASAAAWSIMQQLFVSITFPNFLEAVDISDESETPSKE----SCIKEQTQYFFDS---NDTTFKGTVDCQNCSRQFIAEKLMKTNLVLIVADTEMCSQ-------------MSPGPDPCLISQNPRYRKGP-MECFDNNVNENNEPCGG 1038
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Zebrafish
Match: cacna2d1a (calcium channel, voltage-dependent, alpha 2/delta subunit 1a [Source:ZFIN;Acc:ZDB-GENE-041210-215])

HSP 1 Score: 246.514 bits (628), Expect = 1.398e-66
Identity = 155/545 (28.44%), Postives = 275/545 (50.46%), Query Frame = 2 
Query:  344 KYQYDPHIKPEEVQYINSKDL------PENSELLVD---HPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASNN---LRYQYFASFTGIVLQYPGMRW--RKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-------------FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVI---SLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            ++Q+   +   E  Y N+KD       P  + L++D    P FK  V  N ++VHIPT+IY+  + ILN L WT  L+++F +   +   L +Q F S TG+   +P   W   K   D++DVRRR WY+QGA+SPKD+++L+D SGS+ G+ +KL +++V ++++T+ ++DY+ +  F    N A          ++  CF   VQA+ RNK  L + + ++ A G  +     + A N+    +         ANCN++I++FTD G+    +K   + +  N+ K +RIF + VG+       ++   C  +GY+  I ++GA+     +Y   +    +  + + ++    +   +V  D            LGL+ + T+PV+N++                  LG++  D+++  +  L PH  LG NGY FAI+ NGY++ HP L+ +    ++P  +D  + E + + K  IR  +I+         GE   I   +L+K  DE +  +  RTY+++ V  + + + +V   Y+  Y
Sbjct:  114 EHQWKEDLDVNETIYYNAKDKSDNQTEPRKNRLILDFTEDPAFKRPVSYNTTAVHIPTDIYEGSTIILNELNWTAALDDVFRKNKEDDPSLHWQVFGSATGLARYFPASPWVDSKNKIDLYDVRRRPWYIQGAASPKDMLILVDASGSVSGLTLKLIRTSVSEMLETLSDDDYVNIVSF---NNSA----------KSVACFENLVQANVRNKKTLKEAVQKITANGTTDYKIGFKEAFNQLASMNVSR------ANCNKIIMLFTDGGE----DKASEIFDEYNSDKRVRIFTFSVGQHNYDKAPIQYMACHNKGYYYEIPSIGAIRINTQEYLDVLGRPMVKADKKAKN----VQWTNVYVDALE---------LGLVVTGTLPVFNKTRTSKEKPKGKNLGPSQMILGVMAIDVSLDDIKRLTPHYTLGPNGYYFAIDPNGYVLLHPNLQPKDLKSQEPVTLDFLDAEMEDEVKVDIRRSMID---------GERSQIRFHTLMKSQDERYIDKGFRTYTWSPVTDADYSLALVLPDYSMSY 613

HSP 2 Score: 104.375 bits (259), Expect = 4.326e-22
Identity = 112/497 (22.54%), Postives = 222/497 (44.67%), Query Frame = 2 
Query: 2117 RQYSETKRRKIEKTAAQIVPLGSMD---SSMANTISAIQSF---NISTNPSVIRDK---------------ETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEKVEKFLKR---SDSLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHV-IPIAVLGLSLK-QLPLVSIMQ-------KYEACNKTR-----LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFY--LENIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQP-NRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNS 3484
            R Y+ +     + + A ++P  SM    +++ +TI+  +S+   N++ + S+  DK               E   +  + +T+F ++  + ++ ++  +D +C      RL+ D  +  ++ K   +   SD + +  ++T  G++ V P S    +    + +  S+ ++R+ D + ++F  L         P   N     +  V  S ++ ++ D   +  AV+G+ L  Q  + S M        + E C   R      C L++DGG+++  N  K + Q+G FFG I P +M  L+N S+F     +DYQA+C   ++ + ++    +   T    + +        +  ++ +F+ I     L  +  S   E  + +    SCIK+  +++F+    N    + T  C+NC+      ++  +NL+++  D   CS  C    +P ++     PGPD C +S  PRYR  P  +C+  N +EN   C  
Sbjct:  588 RTYTWSPVTDADYSLALVLPDYSMSYIKATIGDTITQAKSWILENLAVSESLQVDKFEEYGYTLIAPRDYCEDLKAQNENMTQFLIDFNEYID-VKTPNDPQCNMDLMNRLLLDAGITAELVKHWNKNQLSDRIKAKFVATDGGVTRVYPASAGSEWTGQAETY-ESSFYKRSLDNDLYVFTPL---------PFTGNKT---EESVLVSRAMDLRIDEFWLKPAVVGVKLDVQSWMESFMNTTITPKCEGEICGCRRNDEYLDCVLLDDGGFLVMANQDKYIDQIGEFFGMIDPSLMRNLMNVSLFSVNITYDYQALCEPTRESKAAAGLRSVYVPTIADILNIGWWASAAAWSIMQQLFVSITFPNFLEAVDISDESETPSKE----SCIKEQTQYFFDS---NDTTFKGTVDCQNCSRQFIAEKLMKTNLVLIVADTEMCSQMC--EEKPFSQEEKPSPGPDPCLISQNPRYRKGP-MECFDNNVNENNEPCGG 1060
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Xenopus
Match: CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:NCBI gene;Acc:100038148])

HSP 1 Score: 283.108 bits (723), Expect = 1.603e-78
Identity = 182/620 (29.35%), Postives = 326/620 (52.58%), Query Frame = 2 
Query:  113 ENLQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK--------------DLPENSELL--VDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIR---ASNNLRYQYFASFTGIVLQYPGMRWRKKGT-DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYN---RSGNGS----FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            + L+ EFD+ MR  F   Q+  +  +Y++  ++   E     P ++ +  +  + +   KK+ +L+R  + AE+    +++  +I+ E+++Y +SK                P +S  +   D P FK +V  N ++V IPT+IYK  + ILN L WT  L ++FI+       L +Q F S TG+   YP   WR     D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    +                CF   VQA+ RNK  + + + ++ A+G  +     E+A   F +  N +      ANCN++I++FTD G+    ++++ +  + N   K +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +   N+ +    ++   +V +D          +GLGL+ + T+PV+N    SG+       LG++G D+ +  + +L+P   LG NGY FAI+ NGY++ HP LK Q+   ++P  +D  + E + + K +IR K+I     +G E G+  + +L+K  DE +  E  RTY++  +  + + + +V   Y+ YY
Sbjct:   45 KRLEQEFDRVMR-IFGGSQQ--LRGLYND--KRNLFEVKENVPRKLVEKVAGDIESLLAKKVRALRRLAEAAEKFQKAHRWQDNIREEDIEYYDSKADTEYEDLEGEEEPKEPTHSLKIDFADDPNFKAKVNYNYTAVQIPTDIYKGSTVILNELNWTDALEDVFIQNRLEDPTLLWQVFGSATGVTRYYPATPWRAPSKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVMEMLDTLSDDDYVTVASFHEKADPV-------------SCFRQLVQANVRNKKVIKEAVQEMVARGTTDYKAGFEYA---FSQLQNTSIT---RANCNKMIMMFTDGGE----DRVQDVFEKYNWPNKTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGNEAK----QVQWTNVYQDA---------LGLGLVVTGTLPVFNLTEDSGSAGKNQLILGVMGIDVALDDIRKLMPRYSLGANGYMFAIDLNGYVLLHPNLKPQIINFQEPVTLDFLDAELEDENKEEIRRKMI-----DGLE-GQKTIRTLVKSLDERYIDEAERTYTWAPIHSTNYSLGLVLPPYSSYY 617

HSP 2 Score: 102.064 bits (253), Expect = 3.819e-21
Identity = 106/448 (23.66%), Postives = 191/448 (42.63%), Query Frame = 2 
Query: 2276 ISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEKV-EKFLKRSDSLT----SVIMSTLTGLSMVNPKSERHIYKDLFDNWL------NSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSL-------------------------KQLPLVSIMQKYEACNKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAIC-PKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIF---LFIRLLIQLALIHFSSAQEATA--TDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNSDKL 3493
            +   D  T+F    I ++  +   S   C  +    LI D  +   + ++  K  D LT    +V  +T  G++ V P           D+W+      N+T ++R+ D + +IF   +  ++    P    NN+   L V  +  + +    + P AV+G+ L                         K  P  S     +  ++  LC LI+DGG+++  N +    QVG FF ++ P +M  L NNS +   E +DYQ++C PK +  +              + +P +     L +L +     LF  LL+ +    +  A +  A   + +  SCI K  ++YF   ++NS  + +   C  C+   +  R++ +NL+ V  ++  CS  C+ + + ++   +  GP+ C L   PRYR  P + C+ +NP E+   C    L
Sbjct:  657 LEQSDNNTEFLENFISLMEKVTPDSK-HCDSFLLHNLILDTGITRDLADRVWKDKDLLTYGLLAVFAATDGGITRVFPNKAA-------DDWIEDLEPHNATYYRRSLDNKGYIFRAPY--KESGYRPSELENNTVGIL-VSTAVELDIMGKKLKP-AVVGVKLDLESWVEKFKVLASNQSERHPQGPHKCSPSASCEMDCDVNDEELLCVLIDDGGFLVMSNQQDHWSQVGKFFSEVDPNLMSALYNNSFYTRKESYDYQSVCAPKTESNK--------GAAPRGIFVPTIADVLNLAWLTSAAAWSLFQHLLVSVIYGSWLQADDIAAENMEPREASCIMKQTQYYF--GNINSTYSAVID-CGPCSRYFHAQRLSNTNLLFVVAEKMICS-QCD-SMKLDQAETRSEGPEQCDLVQMPRYRKGP-HMCFDYNPMEDTSDCGRGNL 1078
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Xenopus
Match: cacna2d1 (calcium channel, voltage-dependent, alpha 2/delta subunit 1 [Source:NCBI gene;Acc:100036724])

HSP 1 Score: 258.84 bits (660), Expect = 1.727e-70
Identity = 163/578 (28.20%), Postives = 289/578 (50.00%), Query Frame = 2 
Query:  236 NPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDL---PENSE----------LLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIR---ASNNLRYQYFASFTGIVLQYPGMRWRKKG-----TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRS------GNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            N  ++ +  +  +    R + ++L      AEE    +Q+        + Y N+KD    PE ++          +L D P+F+ +     S+VHIPT+IY+  + +LN L WT  L+ +F +       L +Q F S TG+   YP   W  K       D++DVRRR WY+QGA+SPKD+++L+D SGS+ G+ +KL +++V ++++T+ ++D++ V  F    N A  +           CF   VQA+ RNK +L + +  + A+G  +  T  +FA      FD         ANCN++I++FTD G++  KE   +     N  K +R+F + VG+       ++   C+ +G++  I ++GA+     +Y   +    +   ++ +    ++   +V  D            LGL+ + T+PV+N +       N   LG++G D+++  +  L P   L  NGY FA++ NGY++ HP L+ +    ++P  +D  + E ++D K +IR+K+I+       E GE    +L+K  DE +    +RTY++  V  + + + +V   Y  YY
Sbjct:   74 NARQLVQSAATNIEKLLRNRSKALVHLAKKAEEIQESHQWRDQFGTNSIVYYNAKDDQMDPEKNDSDSASQKIKPVLQDDPVFRRQTSYQHSAVHIPTDIYEGSTIVLNELNWTAALDEVFKKNREEDETLLWQVFGSATGLARYYPASPWVDKSRTANKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVAAF---NNNAHDV----------SCFNHLVQANVRNKKKLKEAVNNITAKGTTDYKTGFKFA------FDQLLNHNVSRANCNKIIMLFTDGGEDKAKETFEAY----NKDKTVRVFTFSVGQHNYDKGPIQWMACQNKGFYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAK----QVQWTNVYLDALE---------LGLVITGTLPVFNLTVDHNGKKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFALDPNGYVLLHPNLQPKDLKSQEPVTLDFLDAELENDHKVEIRTKMIDL------ESGESTFQTLVKSQDERYIDRGNRTYTWGPVTGTDYSLGLVLPSYGFYY 609

HSP 2 Score: 75.485 bits (184), Expect = 5.550e-13
Identity = 70/321 (21.81%), Postives = 141/321 (43.93%), Query Frame = 2 
Query: 2543 STMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYEACNKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFI---RLLIQLALIHFSSAQEATATDNKNI----SCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNS 3484
             + ++R+ D + ++F   +  +      D+        + V K+  +T+    + P AV+G+ +     +    +    N    C +++DGG+++  N +  + Q+G FFG+I P +M  L+N S++   + +DYQ++C  + DE +          T  + +P +     L +  +   +    +L   +    F  A E    D  +     SCI +  +++F E+   S    +   C NC+   +V ++  +NL+ +  D T   + C+ N    +   +  GP+ C L+  PRYR  P   C+  +  E+   C  
Sbjct:  746 GSFYKRSLDNDNYVFTAPYFNKTRGSRADSG-------IMVSKAIEITIDGKLLKP-AVVGIKIDVNSWMENFTRDTTKNPQLDCVILDDGGFLLMSNQEDHITQIGRFFGEIDPSLMRQLVNISVYAFNKSYDYQSVC-DQGDEPV------KTAATRSVFVPTIADILNLGWWASAAAWSIMQQLFWSITFPRFLEAAEFDDDDFSSDQSKHSCITEQTQYFF-ENDNRSFSGYL--DCVNCSRIYHVEKILNTNLVFIIIDSTLTCDACD-NQALIQAEQRSNGPNPCLLAQTPRYRKGPDL-CFDQDVGEDDTDCGG 1046
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Xenopus
Match: CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:NCBI gene;Acc:100038148])

HSP 1 Score: 246.514 bits (628), Expect = 5.053e-67
Identity = 150/499 (30.06%), Postives = 262/499 (52.51%), Query Frame = 2 
Query:  425 LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIR---ASNNLRYQYFASFTGIVLQYPGMRWRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGSFLGLLGTDMTVAFMDELVPHDK------LGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
              D P FK +V  N ++V IPT+IYK  + ILN L WT  L ++FI+       L +Q F S TG+   YP   WR     D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    +                CF   VQA+ RNK  + + + ++ A+G  +     E+A ++              ANCN++I++FTD G+    ++++ +  + N   K +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +   N+ +    ++   +V +D            + ++T+L++ +YN+      LG++GT     +++ L  H        LG NGY FAI+ NGY++ HP LK Q+   ++P  +D  + E + + K +IR K+I     +G E G+  + +L+K  DE +  E  RTY++  +  + + + +V   Y+ YY
Sbjct:   58 FADDPNFKAKVNYNYTAVQIPTDIYKGSTVILNELNWTDALEDVFIQNRLEDPTLLWQVFGSATGVTRYYPATPWRAPSKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVMEMLDTLSDDDYVTVASFHEKADPV-------------SCFRQLVQANVRNKKVIKEAVQEMVARGTTDYKAGFEYAFSQLQN------TSITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNKTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGNEAK----QVQWTNVYQDAL----------VSMLTALSI-LYNQ----LILGVMGT----KWVNLLHLHQMKDCLLYLGANGYMFAIDLNGYVLLHPNLKPQIINFQEPVTLDFLDAELEDENKEEIRRKMI-----DGLE-GQKTIRTLVKSLDERYIDEAERTYTWAPIHSTNYSLGLVLPPYSSYY 504

HSP 2 Score: 78.5666 bits (192), Expect = 5.648e-14
Identity = 58/223 (26.01%), Postives = 102/223 (45.74%), Query Frame = 2 
Query: 2792 LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAIC-PKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNP 3457
            LC LI+DGG+++  N +    QVG FF ++ P +M  L NNS +   E +DYQ++C PK +  +              + +P +     L +L +    I     + L   SS     A       C  +++ ++   S+  SL       C+      +  R++ +NL+ V  ++  CS  C+ + + ++   +  GP+ C L   PRYR  P + C+ +NP
Sbjct:  700 LCVLIDDGGFLVMSNQQDHWSQVGKFFSEVDPNLMSALYNNSFYTRKESYDYQSVCAPKTESNK--------GAAPRGIFVPTIADVLNLAWLTSAAACITSATSIPLTQQSS---TVALAPGQYYCNVQHYLYFLYYSNSTSLTPSSLLPCR----YFHAQRLSNTNLLFVVAEKMICS-QCD-SMKLDQAETRSEGPEQCDLVQMPRYRKGP-HMCFDYNP 904
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Xenopus
Match: CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:NCBI gene;Acc:100038148])

HSP 1 Score: 238.81 bits (608), Expect = 2.213e-64
Identity = 162/593 (27.32%), Postives = 294/593 (49.58%), Query Frame = 2 
Query:  239 PLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK--------------DLPENSELL--VDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIR---ASNNLRYQYFASFTGIVLQYPGMRWRKKG-TDMFDVRRRQWYVQGASSPKDVMVLI----DTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYN---RSGNGS----FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGW-----------MRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            P ++ +  +  + +   KK+ +L+R  + AE+    +++  +I+ E+++Y +SK                P +S  +   D P FK +V  N ++V IPT+IYK  + ILN L WT  L ++FI+       L +Q F S TG+   YP   WR     D++DVRRR   V  A S   ++++       SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    +                CF   VQA+ RNK  + + + ++ A+G  +     E+A ++              ANCN++I++FTD G++    +++ +  + N   K +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +   N+ +    ++   +V +D          +GLGL+ + T+PV+N    SG+       LG++G D+ +  + +L+P   LG NGY FAI+ NGY++ HP LK Q+              ++P  +D  + E + + K +IR K+I     +G E G+  + +L+K  DE +  E  RTY++  +  + + + +V   Y+ YY
Sbjct:   28 PRKLVEKVAGDIESLLAKKVRALRRLAEAAEKFQKAHRWQDNIREEDIEYYDSKADTEYEDLEGEEEPKEPTHSLKIDFADDPNFKAKVNYNYTAVQIPTDIYKGSTVILNELNWTDALEDVFIQNRLEDPTLLWQVFGSATGVTRYYPATPWRAPSKIDLYDVRRRPCTVHTACSYAGLLIICLIVSCRSGSVSGLTLKLMKTSVMEMLDTLSDDDYVTVASFHEKADPV-------------SCFRQLVQANVRNKKVIKEAVQEMVARGTTDYKAGFEYAFSQLQN------TSITRANCNKMIMMFTDGGED----RVQDVFEKYNWPNKTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGNEAK----QVQWTNVYQDA---------LGLGLVVTGTLPVFNLTEDSGSAGKNQLILGVMGIDVALDDIRKLMPRYSLGANGYMFAIDLNGYVLLHPNLKPQVCSFSPTKISHIINFQEPVTLDFLDAELEDENKEEIRRKMI-----DGLE-GQKTIRTLVKSLDERYIDEAERTYTWAPIHSTNYSLGLVLPPYSSYY 578

HSP 2 Score: 68.9366 bits (167), Expect = 5.298e-11
Identity = 57/223 (25.56%), Postives = 106/223 (47.53%), Query Frame = 2 
Query: 2855 QVGSFFGQISPLVMDILINNSIFKSIEDFDYQAIC-PKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFI---RLLIQLALIHFSSAQEAT---ATDN---KNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNSDKL 3493
            QVG FF ++ P +M  L NNS +   E +DYQ++C PK +  + ++                V+ +    +    F+       +++  L++ +  Q +T   A +N   +  SCI K  ++YF   ++NS  + +   C  C+   +  R++ +NL+ V  ++  CS  C+ + + ++   +  GP+ C L   PRYR  P + C+ +NP E+   C    L
Sbjct:  735 QVGKFFSEVDPNLMSALYNNSFYTRKESYDYQSVCAPKTESNKGAAPRGI-----------FVVSEHSTSHTTAAFILATSPGCILKAILLNKTFPQISTNDIAAENMEPREASCIMKQTQYYF--GNINSTYSAVID-CGPCSRYFHAQRLSNTNLLFVVAEKMICSQ-CD-SMKLDQAETRSEGPEQCDLVQMPRYRKGP-HMCFDYNPMEDTSDCGRGNL 940
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Xenopus
Match: CACNA2D3 (calcium channel, voltage-dependent, alpha 2/delta subunit 3 [Source:NCBI gene;Acc:101732520])

HSP 1 Score: 230.335 bits (586), Expect = 6.754e-62
Identity = 142/434 (32.72%), Postives = 236/434 (54.38%), Query Frame = 2 
Query:  470 SSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASN---NLRYQYFASFTGIVLQYPGMRWR--KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF-ATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSG-DEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHY-HTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRS----GNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKN--QLGWMRDPPN---VDLTEIEFDSDEKTKIRSKIIN 1720
            S V +PT +Y +D  I+N + W++ LN +F+   +   +L +QYF S  G   QYPG++W   + G   FD R R+WY+Q A+SPKDV++L+D SGSM G+ + + K  V  ++DT+G++D+  +  +    N+ +Q +        +PC   T VQA + NK+   + + +L A+GI  LD AL  A +   +F++      EG+ C++ I++  D   D YD   I +  N  +  + +R+F Y +G E    D ++   C  +G+F  I  +  V   +  Y   +     I +E+ +   E  +D    ++    + +     GL LMT++ MPV++R       G  LG++GTD+ V  + + +P  KLG +GYAFAI  NGYI+ HPEL+   + G  R  PN   VDL+E+E++ D    +R+ ++N
Sbjct:   28 SDVQVPTNVYNKDPEIVNGIYWSEALNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAY----NEEIQYV--------EPCLNGTLVQADRNNKEHFREHLDKLYAKGIGMLDIALNEAFDLLSEFNH----SGEGSVCSQAIMLIADGAVDTYD--NIFAKYNWPD--RKVRMFTYLIGREAAFADNMKWMACANKGFFTQISTLADVQENVMAYLHVLSRPKVIDQEHDVVWTEAYVDSTVSSQSLLADDQ-----GLVLMTTVAMPVFSRQNETRSKGVLLGVVGTDVPVKELMKAIPKYKLGIHGYAFAITNNGYILTHPELRPLYEEGKKRRKPNYSSVDLSEVEWE-DRDDVLRNAMVN 435
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Mouse
Match: Cacna2d2 (calcium channel, voltage-dependent, alpha 2/delta subunit 2 [Source:MGI Symbol;Acc:MGI:1929813])

HSP 1 Score: 286.574 bits (732), Expect = 1.145e-79
Identity = 185/620 (29.84%), Postives = 318/620 (51.29%), Query Frame = 2 
Query:  119 LQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRK-KGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-------FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            L+ E D  MR    V Q   +  IY +   +   E     P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK  + ILN L WT+ L N+FI   R    L +Q F S TG+   YP   WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +      +    ++   +V ED          +GLGL+ + T+PV+N + +G         LG++G D+ +  +  L P+  LG NGY FAI+ NGY++ HP LK Q    R+P  +D  + E + + K +IR  +I+       + G   + +L+K  DE +  E  R Y++  +  + + + +V   Y+ YY
Sbjct:   80 LEQEIDGVMRIFGGVQQ---LREIYKD--NRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEDPNFKNKVNYSYTAVQIPTDIYKGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKDAK----QVQWTNVYEDA---------LGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMID------GDKGHKQIRTLVKSLDERYIDEVIRNYTWVPIRSTNYSLGLVLPPYSTYY 651

HSP 2 Score: 92.8189 bits (229), Expect = 2.182e-18
Identity = 107/445 (24.04%), Postives = 191/445 (42.92%), Query Frame = 2 
Query: 2258 RDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEK-VEKFLKRSD----SLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYE--ACNKTR-------------------------LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATA---TDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNT--QPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN 3481
            R+   +++  D  T+F    I+++  +   S  +C ++    LI D  + ++ VE+  +  D    SL +V  +T  G++ V P      + +  +   N++ ++R+ D   +IF      QD    P    N++   L V  +  +++    + P AV+G+ L    L +  +K++  A N+T                          LC LI+DGG+++  N      QVG FF ++   +M  L NNS +   E +DYQA C  +    + ++   +   T    + +        +     LF +LL  L    +  A  A A    + +  SC+ K  ++YF   S+N+    I   C NC+   +  R+  +NL+ V  ++  CS  C      Q   +   D GP+ C+L   PRYR  P + C+ +N  E+   C 
Sbjct:  685 REYCKDLNASDNNTEFLKNFIELMEKVTPDSK-QCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEP-FNASFYRRSLDNHGYIFKPPH--QDSLLRPLELENDTVGVL-VSTAVELSLGRRTLRP-AVVGVKLD---LEAWAEKFKVLASNRTHQDQPQKQCGPSSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTIADFLNLAWWTSAAAW----SLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYF--GSVNASYNAIID-CGNCSRLFHAQRLTNTNLLFVVAEKPLCS-QCEAGRLLQKETHCPAD-GPEQCELVQRPRYRRGP-HICFDYNATEDTSDCG 1110
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Mouse
Match: Cacna2d2 (calcium channel, voltage-dependent, alpha 2/delta subunit 2 [Source:MGI Symbol;Acc:MGI:1929813])

HSP 1 Score: 286.574 bits (732), Expect = 1.280e-79
Identity = 185/620 (29.84%), Postives = 318/620 (51.29%), Query Frame = 2 
Query:  119 LQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRK-KGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-------FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            L+ E D  MR    V Q   +  IY +   +   E     P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK  + ILN L WT+ L N+FI   R    L +Q F S TG+   YP   WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +      +    ++   +V ED          +GLGL+ + T+PV+N + +G         LG++G D+ +  +  L P+  LG NGY FAI+ NGY++ HP LK Q    R+P  +D  + E + + K +IR  +I+       + G   + +L+K  DE +  E  R Y++  +  + + + +V   Y+ YY
Sbjct:   80 LEQEIDGVMRIFGGVQQ---LREIYKD--NRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEDPNFKNKVNYSYTAVQIPTDIYKGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKDAK----QVQWTNVYEDA---------LGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMID------GDKGHKQIRTLVKSLDERYIDEVIRNYTWVPIRSTNYSLGLVLPPYSTYY 651

HSP 2 Score: 92.8189 bits (229), Expect = 1.894e-18
Identity = 106/441 (24.04%), Postives = 186/441 (42.18%), Query Frame = 2 
Query: 2258 RDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEK-VEKFLKRSD----SLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSL-----------------------KQLPLVSIMQKYEACNKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATA---TDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNT--QPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN 3481
            R+   +++  D  T+F    I+++  +   S  +C ++    LI D  + ++ VE+  +  D    SL +V  +T  G++ V P      + +  +   N++ ++R+ D   +IF      QD    P    N++   L V  +  +++    + P AV+G+ L                       K  P        E  N+  LC LI+DGG+++  N      QVG FF ++   +M  L NNS +   E +DYQA C  +    + ++   +   T    + +        +     LF +LL  L    +  A  A A    + +  SC+ K  ++YF   S+N+    I   C NC+   +  R+  +NL+ V  ++  CS  C      Q   +   D GP+ C+L   PRYR  P + C+ +N  E+   C 
Sbjct:  692 REYCKDLNASDNNTEFLKNFIELMEKVTPDSK-QCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEP-FNASFYRRSLDNHGYIFKPPH--QDSLLRPLELENDTVGVL-VSTAVELSLGRRTLRP-AVVGVKLDLEAWAEKFKVLASNRTHQDQPQKCGPSSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTIADFLNLAWWTSAAAW----SLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYF--GSVNASYNAIID-CGNCSRLFHAQRLTNTNLLFVVAEKPLCS-QCEAGRLLQKETHCPAD-GPEQCELVQRPRYRRGP-HICFDYNATEDTSDCG 1116
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Mouse
Match: Cacna2d2 (calcium channel, voltage-dependent, alpha 2/delta subunit 2 [Source:MGI Symbol;Acc:MGI:1929813])

HSP 1 Score: 286.189 bits (731), Expect = 1.367e-79
Identity = 185/620 (29.84%), Postives = 318/620 (51.29%), Query Frame = 2 
Query:  119 LQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRK-KGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-------FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            L+ E D  MR    V Q   +  IY +   +   E     P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK  + ILN L WT+ L N+FI   R    L +Q F S TG+   YP   WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +      +    ++   +V ED          +GLGL+ + T+PV+N + +G         LG++G D+ +  +  L P+  LG NGY FAI+ NGY++ HP LK Q    R+P  +D  + E + + K +IR  +I+       + G   + +L+K  DE +  E  R Y++  +  + + + +V   Y+ YY
Sbjct:   80 LEQEIDGVMRIFGGVQQ---LREIYKD--NRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEDPNFKNKVNYSYTAVQIPTDIYKGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKDAK----QVQWTNVYEDA---------LGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMID------GDKGHKQIRTLVKSLDERYIDEVIRNYTWVPIRSTNYSLGLVLPPYSTYY 651

HSP 2 Score: 93.9745 bits (232), Expect = 8.208e-19
Identity = 106/443 (23.93%), Postives = 190/443 (42.89%), Query Frame = 2 
Query: 2258 RDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEK-VEKFLKRSD----SLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYE--ACNKTR-------------------------LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATA---TDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN 3481
            R+   +++  D  T+F    I+++  +   S  +C ++    LI D  + ++ VE+  +  D    SL +V  +T  G++ V P      + +  +   N++ ++R+ D   +IF      QD    P    N++   L V  +  +++    + P AV+G+ L    L +  +K++  A N+T                          LC LI+DGG+++  N      QVG FF ++   +M  L NNS +   E +DYQA C  +    + ++   +   T    + +        +     LF +LL  L    +  A  A A    + +  SC+ K  ++YF   S+N+    I   C NC+   +  R+  +NL+ V  ++  CS  C       +    D GP+ C+L   PRYR  P + C+ +N  E+   C 
Sbjct:  685 REYCKDLNASDNNTEFLKNFIELMEKVTPDSK-QCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEP-FNASFYRRSLDNHGYIFKPPH--QDSLLRPLELENDTVGVL-VSTAVELSLGRRTLRP-AVVGVKLD---LEAWAEKFKVLASNRTHQDQPQKQCGPSSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTIADFLNLAWWTSAAAW----SLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYF--GSVNASYNAIID-CGNCSRLFHAQRLTNTNLLFVVAEKPLCS-QCEAGRLLQKETHSD-GPEQCELVQRPRYRRGP-HICFDYNATEDTSDCG 1108
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Mouse
Match: Cacna2d2 (calcium channel, voltage-dependent, alpha 2/delta subunit 2 [Source:MGI Symbol;Acc:MGI:1929813])

HSP 1 Score: 286.189 bits (731), Expect = 1.446e-79
Identity = 185/620 (29.84%), Postives = 318/620 (51.29%), Query Frame = 2 
Query:  119 LQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRK-KGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-------FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            L+ E D  MR    V Q   +  IY +   +   E     P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK  + ILN L WT+ L N+FI   R    L +Q F S TG+   YP   WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +      +    ++   +V ED          +GLGL+ + T+PV+N + +G         LG++G D+ +  +  L P+  LG NGY FAI+ NGY++ HP LK Q    R+P  +D  + E + + K +IR  +I+       + G   + +L+K  DE +  E  R Y++  +  + + + +V   Y+ YY
Sbjct:   80 LEQEIDGVMRIFGGVQQ---LREIYKD--NRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEDPNFKNKVNYSYTAVQIPTDIYKGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKDAK----QVQWTNVYEDA---------LGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMID------GDKGHKQIRTLVKSLDERYIDEVIRNYTWVPIRSTNYSLGLVLPPYSTYY 651

HSP 2 Score: 94.3597 bits (233), Expect = 7.185e-19
Identity = 105/439 (23.92%), Postives = 185/439 (42.14%), Query Frame = 2 
Query: 2258 RDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEK-VEKFLKRSD----SLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSL-----------------------KQLPLVSIMQKYEACNKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATA---TDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN 3481
            R+   +++  D  T+F    I+++  +   S  +C ++    LI D  + ++ VE+  +  D    SL +V  +T  G++ V P      + +  +   N++ ++R+ D   +IF      QD    P    N++   L V  +  +++    + P AV+G+ L                       K  P        E  N+  LC LI+DGG+++  N      QVG FF ++   +M  L NNS +   E +DYQA C  +    + ++   +   T    + +        +     LF +LL  L    +  A  A A    + +  SC+ K  ++YF   S+N+    I   C NC+   +  R+  +NL+ V  ++  CS  C       +    D GP+ C+L   PRYR  P + C+ +N  E+   C 
Sbjct:  692 REYCKDLNASDNNTEFLKNFIELMEKVTPDSK-QCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEP-FNASFYRRSLDNHGYIFKPPH--QDSLLRPLELENDTVGVL-VSTAVELSLGRRTLRP-AVVGVKLDLEAWAEKFKVLASNRTHQDQPQKCGPSSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTIADFLNLAWWTSAAAW----SLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYF--GSVNASYNAIID-CGNCSRLFHAQRLTNTNLLFVVAEKPLCS-QCEAGRLLQKETHSD-GPEQCELVQRPRYRRGP-HICFDYNATEDTSDCG 1114
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Mouse
Match: Cacna2d2 (calcium channel, voltage-dependent, alpha 2/delta subunit 2 [Source:MGI Symbol;Acc:MGI:1929813])

HSP 1 Score: 286.189 bits (731), Expect = 1.487e-79
Identity = 185/620 (29.84%), Postives = 318/620 (51.29%), Query Frame = 2 
Query:  119 LQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRK-KGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-------FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            L+ E D  MR    V Q   +  IY +   +   E     P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK  + ILN L WT+ L N+FI   R    L +Q F S TG+   YP   WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +      +    ++   +V ED          +GLGL+ + T+PV+N + +G         LG++G D+ +  +  L P+  LG NGY FAI+ NGY++ HP LK Q    R+P  +D  + E + + K +IR  +I+       + G   + +L+K  DE +  E  R Y++  +  + + + +V   Y+ YY
Sbjct:   80 LEQEIDGVMRIFGGVQQ---LREIYKD--NRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEDPNFKNKVNYSYTAVQIPTDIYKGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKDAK----QVQWTNVYEDA---------LGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMID------GDKGHKQIRTLVKSLDERYIDEVIRNYTWVPIRSTNYSLGLVLPPYSTYY 651

HSP 2 Score: 92.0485 bits (227), Expect = 2.947e-18
Identity = 107/445 (24.04%), Postives = 191/445 (42.92%), Query Frame = 2 
Query: 2258 RDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEK-VEKFLKRSD----SLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYE--ACNKTR-------------------------LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATA---TDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNT--QPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN 3481
            R+   +++  D  T+F    I+++  +   S  +C ++    LI D  + ++ VE+  +  D    SL +V  +T  G++ V P      + +  +   N++ ++R+ D   +IF      QD    P    N++   L V  +  +++    + P AV+G+ L    L +  +K++  A N+T                          LC LI+DGG+++  N      QVG FF ++   +M  L NNS +   E +DYQA C  +    + ++   +   T    + +        +     LF +LL  L    +  A  A A    + +  SC+ K  ++YF   S+N+    I   C NC+   +  R+  +NL+ V  ++  CS  C      Q   +   D GP+ C+L   PRYR  P + C+ +N  E+   C 
Sbjct:  692 REYCKDLNASDNNTEFLKNFIELMEKVTPDSK-QCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEP-FNASFYRRSLDNHGYIFKPPH--QDSLLRPLELENDTVGVL-VSTAVELSLGRRTLRP-AVVGVKLD---LEAWAEKFKVLASNRTHQDQPQKQCGPSSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTIADFLNLAWWTSAAAW----SLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYF--GSVNASYNAIID-CGNCSRLFHAQRLTNTNLLFVVAEKPLCS-QCEAGRLLQKETHCPAD-GPEQCELVQRPRYRRGP-HICFDYNATEDTSDCG 1117
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. UniProt/SwissProt
Match: sp|Q8CFG6|CA2D2_RAT (Voltage-dependent calcium channel subunit alpha-2/delta-2 OS=Rattus norvegicus OX=10116 GN=Cacna2d2 PE=2 SV=1)

HSP 1 Score: 288.115 bits (736), Expect = 2.999e-79
Identity = 175/580 (30.17%), Postives = 305/580 (52.59%), Query Frame = 2 
Query:  239 PLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRK-KGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-------FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK  + ILN L WT+ L N+FI   R    L +Q F S TG+   YP   WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +      +    ++   +V ED          +GLGL+ + T+PV+N + +G         LG++G D+ +  +  L P+  LG NGY FAI+ NGY++ HP LK Q+   R+P  +D  + E + + K +IR  +I+       + G   + +L+K  DE +  E  R Y++  +  + + + +V   Y+ YY
Sbjct:  115 PQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEEPNFKNKVNYSYTAVQIPTDIYKGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKDAK----QVQWTNVYEDA---------LGLGLVVTGTLPVFNLTQDGPGDKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQITNFREPVTLDFLDAELEDENKEEIRRSMID------GDKGHKQIRTLVKSLDERYIDEVIRNYTWVPIRSTNYSLGLVLPPYSTYY 651

HSP 2 Score: 92.8189 bits (229), Expect = 1.531e-17
Identity = 107/445 (24.04%), Postives = 191/445 (42.92%), Query Frame = 2 
Query: 2258 RDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEK-VEKFLKRSD----SLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYE--ACNKTR-------------------------LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATA---TDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNT--QPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN 3481
            R+   +++  D  T+F    I+++  +   S  +C ++    LI D  + ++ VE+  +  D    SL +V  +T  G++ V P      + +  +   N++ ++R+ D   +IF      QD    P    N++   L V  +  +++    + P AV+G+ L    L +  +K++  A N+T                          LC LI+DGG+++  N      QVG FF ++   +M  L NNS +   E +DYQA C  +    + ++   +   T    + +        +     LF +LL  L    +  A  A A    + +  SC+ K  ++YF   S+N+    I   C NC+   +  R+  +NL+ V  ++  CS  C      Q   +   D GP+ C+L   PRYR  P + C+ +N  E+   C 
Sbjct:  692 REYCKDLNASDNNTEFLKNFIELMEKVTPDSK-QCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEP-FNASFYRRSLDNRGYIFKPPH--QDSLLRPLELENDTVGVL-VSTAVELSLGRRTLRP-AVVGVKLD---LEAWAEKFKVLASNRTHQDQPQKQCGPSSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTIADFLNLAWWTSAAAW----SLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYF--GSVNASYNAIID-CGNCSRLFHAQRLTNTNLLFVVAEKPLCS-QCEVGRLLQKETHCPAD-GPEQCELVQRPRYRTGP-HICFDYNATEDTSDCG 1117
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. UniProt/SwissProt
Match: sp|Q6PHS9|CA2D2_MOUSE (Voltage-dependent calcium channel subunit alpha-2/delta-2 OS=Mus musculus OX=10090 GN=Cacna2d2 PE=1 SV=1)

HSP 1 Score: 286.189 bits (731), Expect = 1.011e-78
Identity = 185/620 (29.84%), Postives = 318/620 (51.29%), Query Frame = 2 
Query:  119 LQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRK-KGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-------FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            L+ E D  MR    V Q   +  IY +   +   E     P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK  + ILN L WT+ L N+FI   R    L +Q F S TG+   YP   WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +      +    ++   +V ED          +GLGL+ + T+PV+N + +G         LG++G D+ +  +  L P+  LG NGY FAI+ NGY++ HP LK Q    R+P  +D  + E + + K +IR  +I+       + G   + +L+K  DE +  E  R Y++  +  + + + +V   Y+ YY
Sbjct:   80 LEQEIDGVMRIFGGVQQ---LREIYKD--NRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEDPNFKNKVNYSYTAVQIPTDIYKGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKDAK----QVQWTNVYEDA---------LGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMID------GDKGHKQIRTLVKSLDERYIDEVIRNYTWVPIRSTNYSLGLVLPPYSTYY 651

HSP 2 Score: 94.3597 bits (233), Expect = 5.026e-18
Identity = 105/439 (23.92%), Postives = 185/439 (42.14%), Query Frame = 2 
Query: 2258 RDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEK-VEKFLKRSD----SLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSL-----------------------KQLPLVSIMQKYEACNKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATA---TDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN 3481
            R+   +++  D  T+F    I+++  +   S  +C ++    LI D  + ++ VE+  +  D    SL +V  +T  G++ V P      + +  +   N++ ++R+ D   +IF      QD    P    N++   L V  +  +++    + P AV+G+ L                       K  P        E  N+  LC LI+DGG+++  N      QVG FF ++   +M  L NNS +   E +DYQA C  +    + ++   +   T    + +        +     LF +LL  L    +  A  A A    + +  SC+ K  ++YF   S+N+    I   C NC+   +  R+  +NL+ V  ++  CS  C       +    D GP+ C+L   PRYR  P + C+ +N  E+   C 
Sbjct:  692 REYCKDLNASDNNTEFLKNFIELMEKVTPDSK-QCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEP-FNASFYRRSLDNHGYIFKPPH--QDSLLRPLELENDTVGVL-VSTAVELSLGRRTLRP-AVVGVKLDLEAWAEKFKVLASNRTHQDQPQKCGPSSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTIADFLNLAWWTSAAAW----SLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYF--GSVNASYNAIID-CGNCSRLFHAQRLTNTNLLFVVAEKPLCS-QCEAGRLLQKETHSD-GPEQCELVQRPRYRRGP-HICFDYNATEDTSDCG 1114
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. UniProt/SwissProt
Match: sp|Q9NY47|CA2D2_HUMAN (Voltage-dependent calcium channel subunit alpha-2/delta-2 OS=Homo sapiens OX=9606 GN=CACNA2D2 PE=1 SV=2)

HSP 1 Score: 284.648 bits (727), Expect = 3.505e-78
Identity = 183/620 (29.52%), Postives = 319/620 (51.45%), Query Frame = 2 
Query:  119 LQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-----DLPENSEL------------LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRK-KGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-------FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            L+ E D  MR    V Q   +  IY +   +   E     P ++ +  +  + +   +K+++LKR  D AE     +++  +IK E++ Y ++K     D PE+ ++             ++ P FK +V  + ++V IPT+IYK  + ILN L WT+ L N+F+   R    L +Q F S TG+   YP   WR  K  D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  Q +          CF   VQA+ RNK ++FK+  Q + A+G        E+A      FD         ANCN++I++FTD G+    ++++ +  + N   + +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +    + +    ++   +V ED          +GLGL+ + T+PV+N + +G         LG++G D+ +  +  L P+  LG NGY FAI+ NGY++ HP LK Q    R+P  +D  + E + + K +IR  +I+         G   + +L+K  DE +  E +R Y++  +  + + + +V   Y+ +Y
Sbjct:   77 LEQEVDGVMRIFGGVQQ---LREIYKD--NRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASF----NEKAQPVS---------CFTHLVQANVRNK-KVFKEAVQGMVAKGTTGYKAGFEYA------FDQLQNSNITRANCNKMIMMFTDGGE----DRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKEAK----QVQWTNVYEDA---------LGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMID------GNKGHKQIRTLVKSLDERYIDEVTRNYTWVPIRSTNYSLGLVLPPYSTFY 648

HSP 2 Score: 94.3597 bits (233), Expect = 4.342e-18
Identity = 105/442 (23.76%), Postives = 190/442 (42.99%), Query Frame = 2 
Query: 2258 RDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEK-VEKFLKRSD----SLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYE--ACNKTR------------------------LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATA---TDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN 3481
            R+   +++  D  T+F    I+++  +   S  +C ++    LI D  + ++ VE+  +  D    SL +V  +T  G++ V P      + +  +   N++ ++R+ D   ++F      QD    P    N++   L V  +  +++    + P AV+G+ L    L +  +K++  A N+T                         LC LI+DGG+++  N      QVG FF ++   +M  L NNS +   E +DYQA C  +    + ++   +   T    + +        +     LF +LL  L    +  A  A A    + +  SC+ K  ++YF   S+N+    I   C NC+   +  R+  +NL+ V  ++  CS  C       +    D GP+ C+L   PRYR  P + C+ +N  E+   C 
Sbjct:  689 REYCKDLNASDNNTEFLKNFIELMEKVTPDSK-QCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEP-FNASFYRRSLDNHGYVFKPPH--QDALLRPLELENDTVGIL-VSTAVELSLGRRTLRP-AVVGVKLD---LEAWAEKFKVLASNRTHQDQPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAW----SLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYF--GSVNASYNAIID-CGNCSRLFHAQRLTNTNLLFVVAEKPLCS-QCEAGRLLQKETHSD-GPEQCELVQRPRYRRGP-HICFDYNATEDTSDCG 1111
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. UniProt/SwissProt
Match: sp|P54289|CA2D1_HUMAN (Voltage-dependent calcium channel subunit alpha-2/delta-1 OS=Homo sapiens OX=9606 GN=CACNA2D1 PE=1 SV=3)

HSP 1 Score: 247.284 bits (630), Expect = 5.406e-66
Identity = 167/594 (28.11%), Postives = 292/594 (49.16%), Query Frame = 2 
Query:  251 AKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDL--PENSE----------LLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASN---NLRYQYFASFTGIVLQYPGMRWRKKG-----TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSG---------NGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKN-------------------QLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            A+D    L+N    + ++L R    AE+    +Q+       EV Y N+KD   PE ++          + ++   F  ++    ++VHIPT+IY+  + +LN L WT  L+ +F +      +L +Q F S TG+   YP   W          D++DVRRR WY+QGA+SPKD+++L+D SGS+ G+ +KL +++V ++++T+ ++D++ V  F    N   Q +          CF   VQA+ RNK  L   +  + A+GI +      FA  +   ++         ANCN++I++FTD G+E  +E    + N+ N  K +R+F + VG+       ++   CE +GY+  I ++GA+     +Y   +    +   ++ +    ++   +V  D            LGL+ + T+PV+N +G         N   LG++G D+++  +  L P   L  NGY FAI+ NGY++ HP L+                    Q    ++P  +D  + E ++D K +IR+K+I+       E GE    +L+K  DE +  + +RTY++T V  + + + +V   Y+ YY
Sbjct:   83 ARDIEKLLSN----RSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASF----NSNAQDVS---------CFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSR------ANCNKIIMLFTDGGEERAQE----IFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAK----QVQWTNVYLDALE---------LGLVITGTLPVFNITGQFENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINLRKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMID------GESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYY 630

HSP 2 Score: 71.2478 bits (173), Expect = 6.083e-11
Identity = 59/235 (25.11%), Postives = 108/235 (45.96%), Query Frame = 2 
Query: 2795 CYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAIC-----PKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNS 3484
            C +++DGG+++  N     +Q+G FFG+I P +M  L+N S++   + +DYQ++C     PK+     S+    +  +  +          IL        F RLL  + +       + TA+ +K  SCI +  +++F+  S  S    +   C NC+   +  ++  +NLI +   E++ +  C+           D GP+ C +  +PRYR  P   C+  N  E++  C  
Sbjct:  850 CVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEM----EDDDFTASLSKQ-SCITEQTQYFFDNDS-KSFSGVL--DCGNCSRIFHGEKLMNTNLIFIMV-ESKGTCPCDTRLLIQAEQTSD-GPNPCDMVKQPRYRKGPDV-CFDNNVLEDYTDCGG 1073
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. UniProt/SwissProt
Match: sp|Q8CFG5|CA2D3_RAT (Voltage-dependent calcium channel subunit alpha-2/delta-3 OS=Rattus norvegicus OX=10116 GN=Cacna2d3 PE=1 SV=1)

HSP 1 Score: 246.899 bits (629), Expect = 6.545e-66
Identity = 165/524 (31.49%), Postives = 275/524 (52.48%), Query Frame = 2 
Query:  233 VNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPE--EVQYINSKD-----LPENSELLV---DHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASN---NLRYQYFASFTGIVLQYPGMRWR--KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF-ATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSG-DEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVS-NIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRS----GNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKN--QLGWMRDPPN---VDLTEIEFDSDEKTKIRSKIIN 1720
            ++ L++ K  +  +   F KK E+++R V+ AEE   K+++D  ++ E      IN +D     L    E ++   DH      V  + S V +PT +Y +D  I+N + W++ LN +F+   +   +L +QYF S  G   QYPG++W   + G   FD R R+WY+Q A+SPKDV++L+D SGSM G+ + + K  V  ++DT+G++D+  +  +    N+ +  +        +PC   T VQA + NK+   + + +L A+GI  LD AL  A N    F++      +G+ C++ I++ TD   D YD     ++  + N   + +RIF Y +G E    D L+   C  +G+F  I  +  V  N+++          I +E+ +   E  ID    ++            GL LMT++ MPV+++       G  LG++GTD+ V  + + +P  KLG +GYAFAI  NGYI+ HPEL+   + G  R  PN   VDL+E+E++ D    +R+ ++N
Sbjct:   82 IDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDH-FNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIITY----NEELHYV--------EPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNVLSDFNHT----GQGSICSQAIMLITDGAVDTYD-----TIFAKYNWPERKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLADD-----------QGLVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRPLYEEGKKRRKPNYSSVDLSEVEWE-DRDDVLRNAMVN 571

HSP 2 Score: 66.2402 bits (160), Expect = 1.637e-9
Identity = 59/237 (24.89%), Postives = 105/237 (44.30%), Query Frame = 2 
Query: 2780 NKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLE-NIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDET-QCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNS 3484
            ++T  CYLI++ G+++   D     Q G FFG++   VM+ L+    FK I  +DYQA+C   K+   S+          L +   ++ + +LF +E N+          +  H     +A         C  +Y  F  +E ++      I   C++C+ S  + ++ +SNL +V  D +  C +       P    I+      C+     + R RP+  C+GF+P+EN  +C  
Sbjct:  845 DETVNCYLIDNNGFILVSED---YTQTGDFFGEVEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDSAHGLLDPYKAFLSAAKWIVTELVLFLVEFNL---------CSWWHSDMTAKAQKLKQTLEPCDTEYPAF-VSERTIKETTGNI--ACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAP--IEIRYNESLKCERLKAQKIRRRPE-SCHGFHPEENARECGG 1063
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. TrEMBL
Match: A0A267DMV8 (VWFA domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig012698g3 PE=4 SV=1)

HSP 1 Score: 523.857 bits (1348), Expect = 1.521e-161
Identity = 384/1227 (31.30%), Postives = 602/1227 (49.06%), Query Frame = 2 
Query:   86 MKMDILSSLENLQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWR--KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAM------QLIKDYPFIQTKP---CFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYD-----KEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYG--EDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIV----NSKYNKYYPVFSQDIKLIKLLECSHVHCSMVVSLPSD-----LNSQLQFTNDIFVYAELGLIGKCKIIKDNXXXXXXXXXXXXXXXXXXRQYSETKRRKIEKTAAQIVPLGSMDSSMANTISAIQSFNISTNPSVIRDKETNISNGDEVTKFSVELIKILNH-LQN------HSDDKCPHYESRRLITDLYVLEKV-EKFLKRSDSLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSF------------------------------PDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLV-SIMQKY--EACN---KTRLCYLIEDGGYVISVNDKKLLHQV-GSFFGQI-SPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILF-YLENIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVS-----------------YDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNS 3484
            ++    +  E L+  F K  R Q  V QE      Y    Q  G      +  +  K+ + KL     +KM ++K  V FAE  A  Y  +P I+  +V YI++K + E+   +    +F  +V+ NQSSVHIP E YK D  +LN + W+ +L+ +F    R    L +Q++ S  GI   +PGM+WR  K   D++DVRRR WY QG++SP+DV+ ++DTSGSMHG A+ LTK AV  LI+T+GEND++AV  +P G+           L++D    ++K    CF +FVQA+KRNKDRLF QI  L A GI N   A++FA + F +F  +    N GA CN +I++FTD GD  D     ++ IR+  NRS     +RIF Y VG+   P + L    C  RGYF  I AMGAV++ ++  +       + R   + + E+ +         +HN      +GLGLMTSLTMP+YN SGN SFLGL+GTD+TV  M+ +VP+ K G NGYAFA+N+NGYI+FHPELK Q GW+ D PNVDL E+EFDS+ K  +R KII         +   E+ + + +K+SD +HTY   R Y++T V  + F +++V     ++Y ++ P  +  I   +    + V   + V   +D      N Q +F +    Y        C+       F            + + Q +  + R+  ++A +  PL         +++  ++ + S  P+++       +   EV    VE I+   H + N      H+   C  +  R +  D+ + E++  +      ++ SV ++ L+G+  V P +E   Y+   + W     +QR F+    IF ++   +  +  P                                      P + +F+  +VTM PD    +AV G++L    +  SI        CN       CYL+EDGGY++S N++   H+V G F G +  PL+  ++ N S++ S++++DYQ  C K K +   +S++ L      L+   + C       LE   L +  L+ LA  H + AQ+         SCIK  +R+Y           E  Q+  +   S+ V  +N +NL++V+                  D     +  ++ T+  R   +DPGPD+C +  E R+R+RP   CY ++P E+  +C S
Sbjct:   38 LRQQAATGAELLRQTFIKESRWQ-RVQQE------YERTYQHSGFRIRNTSAAQEVKNLAKKLTQVVSRKMRAIKELVTFAESAAASYIPNPAIEESQVSYIDAKLVEESDPRMEYDRMFLQKVVKNQSSVHIPVETYKGDVKVLNDIYWSNELDKVFYSNKRKDPELLWQFYGSQNGIFRMFPGMKWRQPKGKIDVYDVRRRPWYTQGSASPRDVLFMVDTSGSMHGQALDLTKLAVVSLINTLGENDFVAVAQYP-GRQVTTDHTAKPHLLRDAVPEESKSNGTCFRSFVQATKRNKDRLFAQINDLSAYGIVNFYEAIDFAYSMFEEF-YKAPVNNHGALCNSMIMIFTD-GDVSDSMDETRQLIRTWRNRSALLDKIRIFTYSVGQHQNPTEPLLEVACSNRGYFAEIPAMGAVTSQVEHITTV-----LSRPMTLYEAEYYL---------WHNIY-LDSLGLGLMTSLTMPLYNTSGNQSFLGLIGTDVTVKEMNAMVPYHKFGPNGYAFAVNSNGYIVFHPELKAQYGWLADSPNVDLIEVEFDSELKRSVRKKIIKATGRTEATFQLYEERIPNFLKISDSVHTYWAERNYAFTNVNRTAFAVSVVLPPSGNRYAEFSPSLAVTISRQRHENPTAVDPFITVIDVTDERGFHPNRQAKFPSKWHEYLVSSKTPYCR-----EYFIPLPPPPPPPPPAPSTQQTPPQVRRQRRSAQEWRPL-------PPSLTTPKAASTSATPTLVPPGNRAAAKPPEV----VEHIRHAPHNMANLLETFMHNRSACNEHWVRAVALDMALYEELFNEMTFVGSTVRSVFVTGLSGIMGVLPAAEASRYQSWREGWFEG-YYQRAFERPDLIFASVVPFKSGEVPPSAGRQEGLAYSEFAAGASTTASTALPVVSNEEIGPAEPPPVTMFQ--AVTMGPDS-FKVAVAGVTLSWRWISGSIFNSTFGSLCNLQLANNTCYLLEDGGYIVSANER---HEVIGHFLGHVDKPLMRHLIYNLSVYGSVQEYDYQGSCIKRKVQPPKNSAASLTVAAGGLASAALGCLATAGNSLERQLLTVPGLVWLA--HSALAQQPD-------SCIKLGYRYYREPQG-----RETFQSVDSLGRSVTVLFLNGTNLLLVAVSRSPAVDPALLLAREPVDGADGDDRLDF-TELLRETREDPGPDVCTM--ESRFRMRPN-SCYRWHPREDSSECGS 1198
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. TrEMBL
Match: A0A267GU03 (VWFA domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig007739g2 PE=4 SV=1)

HSP 1 Score: 437.958 bits (1125), Expect = 1.005e-128
Identity = 248/573 (43.28%), Postives = 346/573 (60.38%), Query Frame = 2 
Query:  266 NKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASNN---LRYQYFASFTGIVLQYPGMRWRKKGT--DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFP-----PGKNQAMQLIKDYPFIQTKP-----CFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTD---SGD-EYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGT-EYG---EDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYYPVFSQDIKL 1915
            N+L     KK+ SL+ AV FAE+    Y  +PH++ + V YI++K L ++   +    +F   V+ N+SSV+IP +++  D   LN + W+ KL+ IF +   N   L +QYF S  GI   +PGM+WRK     DM+DVRRR WY QG+SSPKD++ LIDTSGSM G ++ LTK AV+ LIDT+GEND+IAV  +P     P       LI+D      KP     CF +FVQA++RNK RLF QI  L A GI N +  +EFA N+F  F N++   N+GA CN +I++ +D   SGD E   + IR   ++S+    +RIF Y VG+   PI+ L    CE RG+F  I A GAV++      +  H  T+            + L S +   +HN      +GLGLMTS+T+P+YN SGN SF+GL+GTD+TV  +  +VP  K G  GYAFA+N NGYI+FHPELK Q GW+RDPPNVDL E+EFDS EK ++R +I+N   S G+ E G    + + +L+KV D++HT    RTY++T V  + F I++V       + VF+  IK+
Sbjct:  129 NRLNRIVAKKISSLEDAVRFAEKAVVNYTMNPHLEEKHVTYISAKTLNDSDARMQYDRMFLQSVVMNESSVYIPNDMFNGDVEALNEIVWSTKLDKIFNQNKRNDPDLLWQYFGSQRGIFRIFPGMKWRKPKNEIDMYDVRRRPWYTQGSSSPKDILFLIDTSGSMLGQSLTLTKHAVKSLIDTLGENDFIAVAQYPGKQVSPDHTAKPHLIEDRE--PKKPGANLTCFRSFVQATQRNKKRLFDQIMNLEAYGIVNFNDVIEFAYNQFEMFQNQSVS-NQGAMCNSIIMILSDGDVSGDVESATKLIRRWRSKSHYLDMIRIFTYSVGQHQNPIEPLLQIACENRGFFAEIPARGAVNH------QAQHVTTVLSRP--------MALYSADFYQWHNIY-LDSLGLGLMTSITLPLYNYSGNQSFMGLIGTDVTVKELQAMVPFHKFGPRGYAFAVNANGYIVFHPELKAQNGWLRDPPNVDLIEMEFDSPEKRRVRMRIVNTTGSWGSAENGRIHRESIGTLLKVPDDVHTIWAERTYAFTNVNRTVFAISVVMPPEGNRFAVFNNAIKV 683

HSP 2 Score: 95.1301 bits (235), Expect = 7.665e-16
Identity = 91/312 (29.17%), Postives = 148/312 (47.44%), Query Frame = 2 
Query: 2651 PDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLV-SIMQKY--EACNKTRL---CYLIEDGGYVISVNDKKLLHQVGSFFGQI-SPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLEN---IFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSY--------------------DETQCSNNCNYNT-----QPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN 3481
            P L +F++ ++    D    +AV+G +L    +  SI        C+  R+   CYL+EDGGY++S N+      +G F G +  PL+  ++ N S+++S +++D+QA CPK+  +  S S S    L + L   +     IL  + N   + LF  LL   A I   S+QEAT++ N N SCIK  +R+Y    +     +E  ++  N    I V  +N +NL++ +                     D    S +   +      +  R   +DPGPD+C L  EPR+R RP   CY ++P E+  +C 
Sbjct: 1020 PPLTMFQAVTL----DDGFKVAVVGATLSWRWISQSIFNSTFGSLCDLDRVNNTCYLLEDGGYIVSANEN--FQAIGHFLGHVDKPLMRHLVFNLSVYESEKEYDFQASCPKKSSKRASKSGSSRSALISRLLTALPSISAIL--VSNSLPVGLFNALLWLAAPI---SSQEATSSVNLNESCIKLGYRYYRRPQA-----SESFESRDNLGRKISVLFLNGTNLVLAAASKPPNPLDSALLMSMTPAGSDAADSSESAEQSVGLDYLELRREAREDPGPDVCTL--EPRFRSRPT-SCYNWHPKEDSSECG 1312
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. TrEMBL
Match: A0A267F2P7 (VWFA domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig011769g1 PE=4 SV=1)

HSP 1 Score: 373.244 bits (957), Expect = 3.955e-106
Identity = 227/641 (35.41%), Postives = 352/641 (54.91%), Query Frame = 2 
Query:  116 NLQMEFDKFMRNQFSVFQEPT----IANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKP-EEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASNN-------LRYQYFASFTGIVLQYPGMRWRK-KG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLI--------KDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNR----SNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV-SNIIDKYSKTVHYHTIHRENQME-DNEFRIDLV---SVNEDG-----FHNPEDFPPMGLGLMTSLTMPVYNRSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDD------VISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYYPVFSQDIK 1912
            +L+ E DK       VFQ  +    +  IY +       +    NPL   +  S ++      K +++K +V   EE A  Y+ +P++   E  +Y+ SK+L +++  L  +  F  +V  N S+VHIPT+IY+  + ILN L WTQ+++  FI  + N       +RY Y A+  G++  YPGM+W + +G T M+D RR  W+V+G++  KD++++IDTSGSMHG  + LTK A + LI+T+GENDY+AV  +P GK  + +          K+ P      CF + VQA+KR+K+RLFKQI  ++A+G+ +L  AL+FA   F  + N +   N GA C+ +I +FTD     D EK  +++ R    ++    +RIFI+ VGE   P   L    C  RG F  + AMGAV S++ + Y  T+       E Q+  ++     +V     + +G     F +      +G G++TSLTMP YN SGN SFLGL+GTD+ +     +VP  +LG NGYAFA+N NGY++FHPEL+ + GW + P  +DL E+E D  EK  +R +++   A+ G E   +D      V SL +V D +H ++    Y+Y  +P + + ++I     N  Y  F   I+
Sbjct:   42 SLKSEADKLADQLKKVFQNASGFDNLTKIYVKALADSLFKVEASNPLAEVEQLSEQIGKMVAIKTKAIKESVAIVEEVAATYKQNPNLNEIEHAKYLYSKELKDDNPELEYNRKFLQKVATNASAVHIPTDIYRGRNDILNQLTWTQQVDQQFISMAANEEYFNDTVRYMYLATDMGLMRLYPGMKWTQLEGVTSMYDARRTSWFVEGSTCAKDMLLMIDTSGSMHGQNLLLTKQAAKSLINTLGENDYVAVGQYP-GKALSAEHTDSPHLLHDKEPPENGNGTCFESLVQATKRHKERLFKQIEGIQAKGLVDLAEALDFAYKTFESYQNGSSN-NHGARCSSIIALFTDGDISTDTEKTYNMLRRYKKKNDYLNKVRIFIFSVGEHRNPDGPLIELACSNRGTFTDVPAMGAVTSDVQEGYLTTLRNVGALHEAQLPIESRSGASMVLHSHFDPNGHKTFSFFSENQIRDLGFGVLTSLTMPFYNISGNNSFLGLVGTDIAIKDWVAMVPRQRLGPNGYAFALNANGYVVFHPELRTKNGWHQQPGGLDLLEVELDEPEKRLVRRQVV---ATLGPEQVAEDAAQQVTVESLRRVPDGVHVHKSKMAYAYKRIPGTPYALSIALPAENAGYVAFDSGIR 677
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. TrEMBL
Match: A0A267GUH7 (VWFA domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig027416g1 PE=4 SV=1)

HSP 1 Score: 367.851 bits (943), Expect = 4.977e-106
Identity = 226/651 (34.72%), Postives = 349/651 (53.61%), Query Frame = 2 
Query:  116 NLQMEFDKFMRNQFSVFQEPT----IANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKP-EEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASNN-------LRYQYFASFTGIVLQYPGMRWRK-KG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLI--------KDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNR----SNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAV-SNIIDKYSKTVHYHTIHRENQM--EDNEFRIDLVSVNED-------GFHNPEDFPPMGLGLMTSLTMPVYNRSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDD------VISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYYPVFSQDIKLIKLLECSHV 1942
            +L+ E DK       VFQ  +    +  IY +       +    NPL   +  S ++      K +++K +V   EE A  Y+ +P++   E  +Y+ SK+L +++  L  +  F  +V  N S+VHIPT+IY+  + ILN L WTQ+++  FI  + N       +RY Y A+  G++  YPGM+W + +G T M+D RR  W+V+G++  KD++++IDTSGSMHG  + LTK A + LI+T+GENDY+AV  +P GK  + +          K+ P      CF + VQA+KR+K+RLFKQI  ++A+G+ +L  AL+FA   F  + N +   N GA C+ +I +FTD     D EK  +++ R    ++    +RIFI+ VGE   P   L    C  RG F  + AMGAV S++ + Y  T+       E Q+  E       ++  + D        F +      +G G++TSLTMP YN SGN SFLGL+GTD+ +     +VP  +LG NGYAFA+N NGY++FHPEL+ + GW + P  +DL E+E D  EK  +R +++   A+ G E   +D      V SL +V D +H ++    Y+Y  +P + +   ++           S D   +    C H 
Sbjct:   42 SLKSEADKLADQLKKVFQNASGFDNLTKIYVKALADSLFKVEASNPLAEVEQLSEQIGKMVAIKTKAIKESVAIVEEVAATYKQNPNLNEIEHAKYLYSKELKDDNPELEYNRKFLQKVATNASAVHIPTDIYRGRNDILNQLTWTQQVDQQFISMAANEEYFNDTVRYMYLATDMGLMRLYPGMKWTQLEGVTSMYDARRTSWFVEGSTCAKDMLLMIDTSGSMHGQNLLLTKQAAKSLINTLGENDYVAVGQYP-GKALSAEHTDSPHLLHDKEPPENGNGTCFESLVQATKRHKERLFKQIEGIQAKGLVDLAEALDFAYKTFESYQNGSSN-NHGARCSSIIALFTDGDISTDTEKTYNMLRRYKKKNDYLNKVRIFIFSVGEHRNPDGPLIELACSNRGTFTDVPAMGAVTSDVQEGYLTTLRNVGALHEAQLPIESRSGASMVLHSHFDPNGHKTFSFFSENQIRDLGFGVLTSLTMPFYNISGNNSFLGLVGTDIAIKDWVAMVPRQRLGPNGYAFALNANGYVVFHPELRTKNGWHQQPGGLDLLEVELDEPEKRLVRRQVV---ATLGPEQVAEDAAQQVTVESLRRVPDGVHVHKSKMAYAYKRIPGTPYASKLLPETVYGPGENSSNDCPSVAAPSCCHC 687
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. TrEMBL
Match: A0A2R2MM07 (voltage-dependent calcium channel subunit alpha-2/delta-2-like OS=Lingula unguis OX=7574 GN=LOC106161874 PE=4 SV=1)

HSP 1 Score: 362.459 bits (929), Expect = 3.312e-104
Identity = 199/512 (38.87%), Postives = 298/512 (58.20%), Query Frame = 2 
Query:  383 QYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASN---NLRYQYFASFTGIVLQYPGMRWRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDN---RTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNR---SGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYYP 1891
            ++ N+K L +++  L   P F   +    SSVHIP EIY  D  ILN LKWT+ L++++ + +    NL +QYF    G +  YP   W +   D++DVRRR WY QG+SSPK++M+L+DTSGS  G A++L K  V++L++T+GEND++AV ++   K + +Q    Y       CF  FVQA+ RNK  L + +  L+A G+A  + ALEFA   F +F+     +   N GA+CNR+I+V TD      K++  +++NR N  K +RIF Y +G+    I+ +    C+ RGYF  I AMGA+   + ++     +  ++R   +   +F     SV ED          +GLG+M +LT+PVYNR   S N + LG++G D+T A M+   P  KLG NGYAFA+N NGY +FHP LK QLG+++DPPNVD  E+E ++  K ++R  +IN    N       ++ + +   D  +  EK+R Y YTG+P STF + +V   Y+  YP
Sbjct:    9 KFNNAKTLDKST--LAYSPKFGKGINETISSVHIPVEIYYGDKDILNGLKWTEGLDDVWKQNAEDDPNLLWQYFGGQKGFLRSYPANAWTEAKPDLYDVRRRPWYTQGSSSPKNMMILVDTSGSTTGEALQLMKETVKQLLETLGENDFVAVANY--SKTEEIQDTVRY----VSECFQGFVQATHRNKQVLKEAVMDLQASGMAKWEDALEFAFKAFKEFEQDEKNSSMNNVGADCNRIIMVLTDGATA--KDEAATVLNRENPDKQIRIFTYAIGKTAAAIEAVRWLACKNRGYFSKIPAMGAIRTTVQEF-----FTVLNRPLALAYKQFS-GWTSVYEDA---------LGLGMMITLTLPVYNRSTDSNNQTILGVMGVDVTTAEMENSTPWQKLGPNGYAFAMNWNGYTVFHPNLKAQLGYLKDPPNVDFLEVEHENPAKIELRKMMINNLTGNA------NIETFVISKDLRYASEKNRLYFYTGIPNSTFSLGLVMPDYSIVYP 489

HSP 2 Score: 124.02 bits (310), Expect = 7.861e-25
Identity = 103/388 (26.55%), Postives = 180/388 (46.39%), Query Frame = 2 
Query: 2387 ITDLYVLEKVEKFLKRSDSLTSVI-MSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYEA--CNK---TRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNS--IFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVV-------ICKKILFYLENIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCN-YNTQPNRYPI---KDP-----GPDICKLSNEPRYRLRPKYKCYGFNPDENFMKC 3478
            +T   V E  +   +   S T V+ +ST +GL+ + P +      ++ +   N   ++R  D +  +F   +     +   DN  N + P + V KS S+T K  +    AV+G  + Q  L  +M       C+    T  CYLI+DG +++S N +K   ++G FFG   P +M  L N S  ++  ++++D+Q +C     +++   +S       + SIPV            +++   N  L+  +        ++          KN SC+ +  ++YF +  + SL +E+   C+NCT    V ++  +NL++V   E  C   C+  + +P R P    +DP     GP +C+ S  PRYRLRP+  CY F+  E + KC
Sbjct:  568 VTTQNVTEHWKALSQAYKSATEVVFVSTNSGLTRLYPHNMTEQLLNMANPRENQE-YKRAIDEDHVLFSAPY-----KAVKDNDPNTTGPVVSVMKSISMTEKGGNTYKPAVVGAKMHQTYLTELMNNTSQGQCSDLSLTLFCYLIDDGAFIVSTNQEK--DEIGRFFGATEPALMMELYNGSSPVYNRVQNYDWQGVC-----KQLQLKTSAGPRSFFIPSIPVFEMLTVKWWTSSVMWAYSNFNLYNWIFESAKSFAYAQQDPGDGGSEKNESCVTEQVQYYFTD--VTSLYSELV--CENCTRQYSVEKITGTNLLLV-VAEPPCGPECDPLSPEPKRGPYDTREDPDVPAGGPGVCEASRSPRYRLRPQ-GCYDFDDREEYDKC 936
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Cavefish
Match: cacna2d2b (calcium channel, voltage-dependent, alpha 2/delta subunit 2b [Source:ZFIN;Acc:ZDB-GENE-060503-99])

HSP 1 Score: 261.536 bits (667), Expect = 4.982e-72
Identity = 171/530 (32.26%), Postives = 282/530 (53.21%), Query Frame = 2 
Query:  236 NPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIK-PEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQ-IFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGSF-----LGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEI 1792
            NP EI +  ++ +     KK  +L++    AE     +++   IK  +E +   S  L    E + D P FK  V  + ++V IPT+IYK    ILN L WTQ L  +F+   R   +L +Q F S TG+   YP   WR     D++DVRRR WY+QGASSPKD+++L+D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  + +         PCF   VQA+ RNK R+FK+ + Q++A+G  +  +   FA N+     N        ANCN++I++FTD G++  ++ I    N  N  K +R+F + VG+    +  L+   C  +GY+  I ++ A+     +Y   +    +      +    ++   +V +D          +GLGL+ + TMPV+N S +G+F     LG++G D+ +  +  L P   LG NGY FAI+ NGY++ HP L+ ++  + +P  +D  + E +   K +IR ++I+  A      GE  + +L+K  DE+
Sbjct:   41 NPREIVEKVASDIEKLLAKKKRALEKLASEAERVQKAHRWQDSIKDGDEFEAQMSLKL----EFVYD-PNFKNNVNYSYTAVQIPTDIYKGAPVILNELNWTQALERVFMENSREDPSLLWQAFGSATGVTRYYPATPWRAPDKIDLYDVRRRPWYIQGASSPKDMVILVDVSGSVSGLTLKLIKASVTEMLDTLSDDDYVNVARF----NEKAEAV--------VPCFKHLVQANVRNK-RIFKEHVSQMQAKGTTDYKSGFRFAFNQLLNNTNVPR-----ANCNKIIMLFTDGGEDRAQD-IFEQHNWPN--KTVRVFTFSVGQHNYDVTPLQWIACANKGYYFEIRSICAIRINTQEYLDVLGRPMVLAGRSAK----QVQWTNVYQDA---------LGLGLVVTGTMPVFNLSMDGNFQNQLILGVMGVDVHLDELKRLAPRYNLGANGYIFAIDPNGYLLLHPNLQAKVVDLPEPVTLDFLDAEVEDISKQEIRRQMIDGRA------GEMTIKTLVKSMDEV 525

HSP 2 Score: 90.1225 bits (222), Expect = 1.029e-17
Identity = 83/329 (25.23%), Postives = 146/329 (44.38%), Query Frame = 2 
Query: 2537 LNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLV--------SIMQKYEACNKTR-----LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICK-KILFYLENIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN 3481
            LNS  ++R+ D + +IF      +   ++P  + N +   L V  +  +T+    V+  AV+G+ L     V        ++    +  +K       LCYLI+DGG+++  N +    +VG FFG + P +M  L NNSI+   + F YQ+ C         ++  R    +    + +     KI+F + +I   +   +      F+   EA  +     SC+    +FYF  S+ NS    + Q C NC+   +  R++ +NL+ V  +   CS+         R   ++  P  C + +  RYR  P+ KC+ +N  EN  +C 
Sbjct:  670 LNSNFYRRSLDNKGYIFRA--PTRTSMEDPLITENGTVGIL-VTTAVEITVG-GKVLKPAVVGVKLDLEAWVDKFKILASNVSDSRQGSHKVGDSLDLLCYLIDDGGFLVMSNQRDHWKKVGMFFGDVDPYLMHALYNNSIYARRQSFQYQSACEPTASSRTGAAPRRFFVPSIADMLNLAWWTYKIMFAVTSILNCVVGDV------FAEGTEAKGSS----SCVTIQSQFYFTNST-NSF--NVLQDCGNCSRLFHAKRIDNTNLLFVVAETLPCSSCEIERLTQVRTEFQEEIP--CDVLSSARYRKGPE-KCFDYNEGENTSECG 978
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Cavefish
Match: si:dkey-266j7.2 (calcium voltage-gated channel auxiliary subunit alpha2delta 1 [Source:HGNC Symbol;Acc:HGNC:1399])

HSP 1 Score: 249.98 bits (637), Expect = 3.560e-68
Identity = 158/517 (30.56%), Postives = 266/517 (51.45%), Query Frame = 2 
Query:  431 DHPLFKTRVIA-NQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASN---NLRYQYFASFTGIVLQYPGMRWRK-----KGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRE-NQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRS-GNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYYPVFS-QDIKLIKLLECSHVH 1945
            + P FK R+I+ N S+VHIPT+IY   + +LN L WT+ L ++F +       L +Q F S TG+   YP   W+         D++DVRRR WYVQGA+SPKD+++L+D SGS+ G+ +KL +++V ++++T+ ++DY+ V +F    N                CF   VQA+ RNK  L   +  + A+GI N     EFA      F   ++     ANCN++I++FTD G+E  +E    + +R N  K +RIF + VG+       ++   C  +GYF  I ++GA+     +Y   +    +  +  Q++     +D + +++   H         L     +++  Y  S  N   LG++G D+++  +  L P   +G NGY FAI+ NGY++ HP L+ +    ++P  +D  + E ++D K +IR+ +I+    N T      + +L+K  DE +     RTY++  V  + + + +V  +YN +Y   S  D+   K  E   V 
Sbjct:   99 EDPSFKNRLISYNHSAVHIPTDIYDGSTIVLNELNWTEALEDVFKKNREEDPTLLWQVFGSATGLARYYPASPWKDARKTPSKIDLYDVRRRPWYVQGAASPKDMLILVDASGSVSGLTLKLIRTSVSEMLETLSDDDYVNVVNFNTRVNNTA-------------CFDHLVQANVRNKKILKDGVQNITAKGITNYTKGFEFA------FKQLSDPNVTRANCNKIIMLFTDGGEERAQE----IFSRYNPEKKVRIFTFSVGQHNYDTGPIQWMACANKGYFYEIPSIGAIRINTQEYLDVLGRPMVLADAKQVQWTNVYLDALVISDLQVH---------LKKKNRISLRSYFISHQNQLILGVMGVDVSLDDIKRLTPRFTIGPNGYYFAIDPNGYVLLHPNLQPKNPKFQEPVTLDFLDAELENDIKVQIRTMMIDRVPGNKT------IDTLVKTQDERYIDRGVRTYTWAPVNGTDYSLALVLPEYNMHYIEASLGDLNQAKFFETMQVE 577

HSP 2 Score: 79.337 bits (194), Expect = 1.766e-14
Identity = 83/389 (21.34%), Postives = 167/389 (42.93%), Query Frame = 2 
Query: 2381 RLITDLYVLEKVEKFLKRS--DSLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGL----------SLKQLPLVSIMQKYEACNKTRL----CYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDP-----GPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNS 3484
            RL+ D  +  ++    K+   + + +  ++T  G++ V PKS    + +  +   +S+ ++R+ D + +IF   +    L K  ++S  +    + V K+  +  +   + P AV+G+          SL  L L      +     T      C +++DGG+++  N ++ + Q+G FFG++ P++M  L+N S++   + +DYQ++C  E++ + +S    +   T    + V        +     +   LL+ L   H                CI +  +++F   + +    +    C NC+      ++ ++NL+ +  D      +C+        P+K       GPD C L+  PRYR  P   C+  N DE+   C  
Sbjct:  623 RLLLDAGLTAELVTLWKKQPIEGVLARFVATDGGITRVYPKSGGEEWTENAET-FDSSFYKRSLDNDIYIFTAPY----LNKSRESSYESG---ILVSKAVELDFRGVKLKP-AVVGVKLNVSAWMNSSLDGLILCFSDFFFFFVVSTLGQHVDCVILDDGGFLLMSNQEEYITQIGQFFGEVDPVLMISLVNTSLYSFNKTYDYQSVCDPERETKAASGPRSVYVPTIADMLSVGWWASTAAW----SMLQHLLLTLTYPH----------------CITEQTQYFFENDNRS---FQGVLDCGNCSRMYRAEKLPSTNLVFLITDAKSTCLSCDPK------PLKQAEQPSIGPDPCMLAQNPRYRKGPDV-CFDNNDDEDASDCGG 972
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Cavefish
Match: CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3 [Source:NCBI gene;Acc:103032408])

HSP 1 Score: 244.588 bits (623), Expect = 2.784e-66
Identity = 170/526 (32.32%), Postives = 279/526 (53.04%), Query Frame = 2 
Query:  233 VNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINS------KDLPENSEL---LVDHP---LFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWR--KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF-ATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSG-DEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVS-NIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVY---NRSGN-GSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKN--QLGWMRDPPN---VDLTEIEFDSDEKTKIRSKIIN 1720
            ++ L++ +  +  +   F KK E++KR V+ AEE   +++ DP+++ E   Y N+       D+  N EL    +  P        V  + S V +PT +Y +DS I+N + W++ LN +F+       +L +QYF S  G   QYPG++W   + G   FD R R+WY+Q A+SPKDV++L+D SGSM G+ + + K  V  ++DT+G++D+  +  +    N+ +  +        +PC   T VQA   NKD   + + +L A+GI  LD AL  A      F N+T +   G+ C++ I++ TD   D YD     ++  + N   + +RIF Y +G E    D L+   C  +GYF  I  +  V  N+++          I +E+ +   E  ID   + ++           G GLMT++ MPV+   N + N G  LG++GTD+ V+ + + +P  KLG +GYAFAI  NGYI+ HP+L+   + G  R  PN   VDL+E+E++ D+   +R+ ++N
Sbjct:   30 IDGLKLVERLAKNMEEMFHKKAEAMKRLVEAAEEAHLQHEEDPNLQYE---YFNAVLINELDDVGNNVELGGEFILQPNDHFNNLSVNLSLSVVQVPTNMYNKDSAIVNGVYWSEALNKVFVDNFERDPSLIWQYFGSAKGFFRQYPGIKWTPDEHGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAY----NEELHYV--------EPCLNGTLVQADVTNKDHFREHLDKLFAKGIGMLDVALTEAFELLTDF-NQTGR---GSVCSQAIMLVTDGAVDTYD-----TVFAKYNWPDRKVRIFPYLIGRESAFADNLKWMACANKGYFTQISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDNTQMEDN----------QGPGLMTTVAMPVFSTKNETKNKGILLGVVGTDVPVSELLKTIPKYKLGIHGYAFAITNNGYILTHPDLRPLYEEGKKRRKPNYSSVDLSEVEWE-DKDDVLRNAMVN 520
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Cavefish
Match: CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3 [Source:NCBI gene;Acc:103032408])

HSP 1 Score: 244.973 bits (624), Expect = 3.238e-66
Identity = 170/526 (32.32%), Postives = 279/526 (53.04%), Query Frame = 2 
Query:  233 VNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINS------KDLPENSEL---LVDHP---LFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWR--KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF-ATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSG-DEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVS-NIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVY---NRSGN-GSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKN--QLGWMRDPPN---VDLTEIEFDSDEKTKIRSKIIN 1720
            ++ L++ +  +  +   F KK E++KR V+ AEE   +++ DP+++ E   Y N+       D+  N EL    +  P        V  + S V +PT +Y +DS I+N + W++ LN +F+       +L +QYF S  G   QYPG++W   + G   FD R R+WY+Q A+SPKDV++L+D SGSM G+ + + K  V  ++DT+G++D+  +  +    N+ +  +        +PC   T VQA   NKD   + + +L A+GI  LD AL  A      F N+T +   G+ C++ I++ TD   D YD     ++  + N   + +RIF Y +G E    D L+   C  +GYF  I  +  V  N+++          I +E+ +   E  ID   + ++           G GLMT++ MPV+   N + N G  LG++GTD+ V+ + + +P  KLG +GYAFAI  NGYI+ HP+L+   + G  R  PN   VDL+E+E++ D+   +R+ ++N
Sbjct:   82 IDGLKLVERLAKNMEEMFHKKAEAMKRLVEAAEEAHLQHEEDPNLQYE---YFNAVLINELDDVGNNVELGGEFILQPNDHFNNLSVNLSLSVVQVPTNMYNKDSAIVNGVYWSEALNKVFVDNFERDPSLIWQYFGSAKGFFRQYPGIKWTPDEHGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAY----NEELHYV--------EPCLNGTLVQADVTNKDHFREHLDKLFAKGIGMLDVALTEAFELLTDF-NQTGR---GSVCSQAIMLVTDGAVDTYD-----TVFAKYNWPDRKVRIFPYLIGRESAFADNLKWMACANKGYFTQISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDNTQMEDN----------QGPGLMTTVAMPVFSTKNETKNKGILLGVVGTDVPVSELLKTIPKYKLGIHGYAFAITNNGYILTHPDLRPLYEEGKKRRKPNYSSVDLSEVEWE-DKDDVLRNAMVN 572
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Cavefish
Match: CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3 [Source:NCBI gene;Acc:103032408])

HSP 1 Score: 244.202 bits (622), Expect = 3.512e-66
Identity = 172/526 (32.70%), Postives = 279/526 (53.04%), Query Frame = 2 
Query:  233 VNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINS------KDLPENSEL---LVDHP---LFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWR--KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF-ATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSG-DEYDKEKIRSLMNRSN-TTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVS-NIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVY---NRSGN-GSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKN--QLGWMRDPPN---VDLTEIEFDSDEKTKIRSKIIN 1720
            ++ L++ +  +  +   F KK E++KR V+ AEE   +++ DP+++ E   Y N+       D+  N EL    +  P        V  + S V +PT +Y +DS I+N + W++ LN +F+       +L +QYF S  G   QYPG++W   + G   FD R R+WY+Q A+SPKDV++L+D SGSM G+ + + K  V  ++DT+G++D+  +  +    N+ +  +        +PC   T VQA   NKD   + + +L A+GI  LD AL  A      F N+T +   G+ C++ I++ TD   D YD     ++  + N   + +RIF Y +G E    D L+   C  +GYF  I  +  V  N+++          I +E+ +   E  ID  +  ED           G GLMT++ MPV+   N + N G  LG++GTD+ V+ + + +P  KLG +GYAFAI  NGYI+ HP+L+   + G  R  PN   VDL+E+E++ D+   +R+ ++N
Sbjct:   82 IDGLKLVERLAKNMEEMFHKKAEAMKRLVEAAEEAHLQHEEDPNLQYE---YFNAVLINELDDVGNNVELGGEFILQPNDHFNNLSVNLSLSVVQVPTNMYNKDSAIVNGVYWSEALNKVFVDNFERDPSLIWQYFGSAKGFFRQYPGIKWTPDEHGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAY----NEELHYV--------EPCLNGTLVQADVTNKDHFREHLDKLFAKGIGMLDVALTEAFELLTDF-NQTGR---GSVCSQAIMLVTDGAVDTYD-----TVFAKYNWPDRKVRIFPYLIGRESAFADNLKWMACANKGYFTQISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYID--NTMEDN---------QGPGLMTTVAMPVFSTKNETKNKGILLGVVGTDVPVSELLKTIPKYKLGIHGYAFAITNNGYILTHPDLRPLYEEGKKRRKPNYSSVDLSEVEWE-DKDDVLRNAMVN 571
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Sea Lamprey
Match: cacna2d1a (calcium channel, voltage-dependent, alpha 2/delta subunit 1a [Source:ZFIN;Acc:ZDB-GENE-041210-215])

HSP 1 Score: 217.238 bits (552), Expect = 2.542e-58
Identity = 145/492 (29.47%), Postives = 243/492 (49.39%), Query Frame = 2 
Query:  509 SFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS---------FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQ---------LGWMRD----------PPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            + ILN L WT  L+ +F         L +Q F S TG+   YP   W   G  D+FDVRRR WY+QGASSPKD++++ID SGS+ G+ +KL K +V ++++T+ ++DY+ V  F    N+A+ +           CF   VQA+ RNK  L + + +L A+G+ N   A  +A      F+         ANCN++I++FTD G++  ++      N +   K +R+F + VG+    +  ++   C  +G++  I ++GA+      Y   +    +    + +    ++   +V +D          + LGL+ + TMPV+N S N            LG++G D+++  + +L     LG NGY FAI+ NGY++ HP LK +         + + RD          P  +D  + E ++D K  IR  +I+       + G      LIK  DE +  +  RTY++T +  + + + +V   Y+ YY
Sbjct:   19 TIILNELNWTAGLDEVFKLNKEEDPTLLWQVFGSATGLTRFYPATPWVAPGDVDLFDVRRRPWYIQGASSPKDMVIIIDVSGSVSGLTLKLMKKSVSEMLETLSDDDYVNVASF---HNEAVPV----------SCFNHLVQANVRNKQMLSESVEKLTAKGMTNYKAAFTYA------FEQLLNTNVTRANCNKMIMMFTDGGEDRAQDVFE---NYNWPKKEVRVFTFSVGQHNYNVAPIQWMACANKGFYFEIPSIGAIRINTQDYLDVLGRPMVLAGPKAK----KVQWTNVYKDA---------LNLGLVITGTMPVFNISKNAGNKIHLKNQLLLGVMGVDISLDDIKKLTTQYNLGPNGYFFAIDPNGYVLLHPNLKPKVLSLAVPLIIRYPRDVNYMVTKFEEPVTLDFLDAELENDIKLLIRQSMID------KKSGMRTFEMLIKSLDERYIDKSMRTYTWTPMQSAEYSLALVLPSYSNYY 469

HSP 2 Score: 75.0998 bits (183), Expect = 6.920e-14
Identity = 60/236 (25.42%), Postives = 108/236 (45.76%), Query Frame = 2 
Query: 2795 CYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIH-FSSAQEAT-ATDNKN-ISCIKKYHRFYF--NESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYD--ETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN 3481
            C +++DGG+++  N +    ++G FFG++ P +   +   +++  +E +DYQ++C    D    S +        +  I  ++     F      L  +LL  + + + FS + +A    D K  +SC+    ++YF  N  S + L       C NCT   +  ++ TSNL++V  +    +C+  C              GPD C L+  PRYR  P   C+ +N DE+  +C 
Sbjct:  703 CVVLDDGGFLVFSNQESHQEKLGEFFGEVDPHLFHEMHRLAVYSRVESYDYQSVC----DPPPESHAGAAHRSIRIPKIYDILNLAWWFSAAAWSLLQQLLCGITVPNLFSPSVDARDPLDLKGKVSCVMLQTQYYFPNNNKSFHKL-----IDCGNCTRYFHAEKLGTSNLVLVVAELFSKECT-VCEVRKIKQAKQNSAQGPDPCLLAETPRYRKGPD-ACFDYNVDEDVSECG 927
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Sea Lamprey
Match: cacna2d4b (calcium channel, voltage-dependent, alpha 2/delta subunit 4b [Source:ZFIN;Acc:ZDB-GENE-100422-18])

HSP 1 Score: 174.866 bits (442), Expect = 6.899e-47
Identity = 123/463 (26.57%), Postives = 232/463 (50.11%), Query Frame = 2 
Query:  242 LEIAKDFSNKLANEFRKKMES-LKRAVDFAEEEATKYQYDPHIKPE--EVQYINSKDLPEN-----SELLVDHPLFKTRVIANQS--SVHIPTEIYKEDSFILNTLKWTQKLNNIF---IRASNNLRYQYFASFTGIVLQYPGMRWR--KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF-ATFVQASKRNKDRLFKQIFQ-LRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRS----GNGSFLGLLGTDMTVAFMDELVPHDKLGRNG 1567
            L++ +  +  + +   +K E+ ++R V+ AEE   K++++  ++ +     +IN  D   N      E +++       +  N S  +V +PT +Y ++  I+N   W++ LN +F         L +QY+ S TG   QYPG++W   + G   FD R R WY+Q A+SPKD+++L+D SGSM G+ + + K  +  ++DT+G+ND++ V  +    N+ +  I        +PCF    VQA++ N++  FKQ+ + + AQG+A+L  ALE       +F+       +G++CN+ ++V TD   E  +E        ++  K +RIF Y +G E+   + ++   C  + +F  I  +   +N        V    I+    ++         ++ +   ++       GL LMT++ MPV+++      +G  LG++GTD+ +  + ++ P  K+   G
Sbjct:   18 LKMVRKLARLMEDMLSRKTEAEIQRLVEAAEEADLKHEFNSEMQYDYYNAVFINDVDEEGNYIELAREFILEPNAHFNNLAVNTSLSNVQVPTNVYNKEPNIVNGAFWSEALNPVFEDNFERDATLTWQYYGSSTGFFRQYPGIKWTPDENGVISFDCRNRGWYIQAATSPKDIVILVDVSGSMKGLRLTIAKQTISTILDTLGDNDFVNVIAY----NEQLHYI--------EPCFEGGMVQANRDNREH-FKQLLEDMHAQGVADLANALEEGFVILDQFN----ATGQGSSCNQALMVVTDGAVETFEEVFEKY---NSPDKKVRIFTYLIGRELAFANPIKWMACANKAHFTRIIVLKDTTN-------NVVCLIIYFVMLLKHTRPLCHFCAMKKSFLYSTSS---QGLLLMTTVAMPVFSKKNETRSHGILLGVVGTDVPLKELLKMAPRYKVCSEG 450
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001351.1 (pep scaffold:Pmarinus_7.0:GL479089:992:16661:1 gene:ENSPMAG00000001205.1 transcript:ENSPMAT00000001351.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 90.8929 bits (224), Expect = 2.281e-19
Identity = 92/407 (22.60%), Postives = 173/407 (42.51%), Query Frame = 2 
Query: 2387 ITDLYVLEKVEKFLKRSDSLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDH-VIPIAVLGLSLKQLPLVSIMQKYEACNKTR-------------------------LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLAL-IHFSSAQEATATDNKNISCIKKYHRFYF--NESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQC---------SNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNSDKL 3493
            IT+    E  +   K +  + +  ++T +G++ + P  E   + +  + + N++ ++R+ D E F++  +  I           +N   ++ +  S +V ++ D  V+  AV+G+ L +L + +   K  A N T                           C +++DGG++I  N +    +VG FFG + P +M  L N S+F  +E +DYQ+ C  EK+ +  ++   +        + V        +     LF  L +Q      FS A  A   +   +SCI    ++YF  N+++   L       C NC+   +  ++  SNL+ V  ++  C             N+  +P   P    GP++C+L+  PRYR  P   C+ +N  E+   C    +
Sbjct:   10 ITNRLAKEAWQDLNKSTHGIKTFFVATDSGVTRIYPLEEVEDWDEEPEPY-NASYYKRSLDNEGFVYKPVIPIS-------KGGSNDPSNISILASRAVEVEIDGKVLKPAVVGVKL-ELEVWTAKFKLLASNHTGEGRRHLQCDSLGSCEMDCDLSSKELQCVILDDGGFLIMSNQEDQEKKVGEFFGVVDPSLMRALYNVSLFAKVESYDYQSTCDPEKEPKAGAAPRSIAIPRISDVLNVAWLASAAAWSLLQQLFYSLTLQTWYSADFSYADGANYKE--KVSCITLQTQYYFPNNKTTFQEL-----MDCGNCSRFFFAEKLANSNLVFVVSEKIMCPMCDNRPLIQAEQNFLDEP---PRTADGPNMCELA--PRYRKGPD-SCFDYNILEDTSDCGRGSM 394
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Nematostella
Match: EDO44603 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RV93])

HSP 1 Score: 123.25 bits (308), Expect = 2.528e-28
Identity = 139/589 (23.60%), Postives = 242/589 (41.09%), Query Frame = 2 
Query:  242 LEIAKDFSNKLANEFRKKMESLKRAVDFAEEEA---------TKYQYDP---HIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIF---IRASNNLRYQYFASFTGIVLQYPGMRWRKKGTDM---FDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGD------------------------EYDKEKIRSLMNRSNTTKN--LRIFIYYV---GEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIE---FDSDEKTKIRSKIINCAASNGTEYGEDDVISLIK--VSDEIHTYEKSRTYSYTGVPYSTFG 1852
            LE  K   + L N F KK ++ K+    AEE A         +K Q++    ++K   V +   KD+ +    L    LFK RV  ++S++ I  ++ + D  ++ T+ W+ KL+ +F   +     LR+Q F S  G++ QYP   W+         +D R R WY+   S PKD+++++D S SM G  +++ K   + +++T+ + D++ V                             +     N D + K  F+           A E              KG     C  +I+  TD  D                        +YD  K+ + +   N   N   RIF Y     GEE          +C+  GY   +       NII   S+   Y++    N           +S+N   +  P      GLGLM ++ MPV ++  N + +G++G D T+  ++ ++ +D+ G + YAF IN  G  IFHP L+     + DP  + ++++E    +  E +K++  +++     G+   E+ + S+ K    D +       TY YT +  S + 
Sbjct:   69 LETIKSVKDLLGNYFVKKEQAAKK---LAEEVAELHDKFYTNSKLQHNAKVTNLKDLGVDHYTDKDIVKTLPDLEFDTLFKMRVSKSKSAIKISDQVVRNDKNLIETVYWSSKLDEMFKKNLADDPELRWQNFGSVEGVLRQYPSSEWQTNFAGFHIDYDPRMRPWYIGATSGPKDIVIILDCSLSMKGKRLRMAKEIAKTVLNTLTKQDFVNV-----------------------------ICGHASNWDEVGKAAFK----------KAFELL------------KGRAKTGCQSIIIFVTDGEDNDGDPVRCGQGYYTRSGYVPGQLCKYDWAKVWNEVEAINKYMNPRTRIFSYLTNDRGEEFP-----GKLSCDNNGYMKRLVDN---ENII---SQMQEYYSFLASNT----------ISINNVTWTAPY-LDASGLGLMVTVAMPVTSKLTNRT-IGVVGIDATLEEIENILQNDQWG-SVYAFLINDEGETIFHPLLRPSTELVDDPIFIQISDLEQRDGEPKEFSKVQEAMMD--GKTGSYRIENAIRSIPKGDFQDGVVLVTSPSTYFYTSIKDSVYA 577
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Nematostella
Match: EDO29939 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T278])

HSP 1 Score: 101.293 bits (251), Expect = 2.016e-25
Identity = 49/109 (44.95%), Postives = 70/109 (64.22%), Query Frame = 2 
Query:  515 ILNTLKWTQKLNNIF---IRASNNLRYQYFASFTGIVLQYPGMRWRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAV 829
            ILN+ KWT+ L+  F   +    +L +Q   + TG+   YPG +WR     DM+D RRR WY+QG+SSPKD+++L+D SGSM G  I + K A   L+DT+ END++ V
Sbjct:    2 ILNSAKWTEGLDKYFRENMEKEPSLLWQLAGTSTGVYRAYPGYKWRTPNDKDMYDHRRRGWYIQGSSSPKDMVILLDLSGSMTGSKIAIVKLAATYLLDTLQENDFVNV 110
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Nematostella
Match: EDO38678 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCF0])

HSP 1 Score: 99.3673 bits (246), Expect = 1.541e-24
Identity = 46/110 (41.82%), Postives = 68/110 (61.82%), Query Frame = 2 
Query:  515 ILNTLKWTQKLNNIFIRASNN---LRYQYFASFTGIVLQYPGMRWRKKG--TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAV 829
            +LN LKW++ LN  F     N   L +QYF    G +  YPG  W +     D++D R+R WY+QGA+SPKDV++++D SGSM G+ +++ K +   LIDT  +ND+  V
Sbjct:    1 MLNGLKWSEALNEAFTENQKNDPTLAWQYFGHDNGFMRVYPGSAWNQPNGQVDLYDARKRIWYIQGATSPKDVIIMVDASGSMRGVPMRIAKLSAMALIDTFEDNDFFNV 110
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Nematostella
Match: EDO48210 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKA1])

HSP 1 Score: 105.531 bits (262), Expect = 7.879e-23
Identity = 123/486 (25.31%), Postives = 206/486 (42.39%), Query Frame = 2 
Query:  314 AVDFAEEEATKYQYDPHIKPE-EVQYINSKDLPENSEL-------LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASNNLRYQYFASFTGIVLQYPGMRWRKKGTDMFDVRRRQWYVQGAS-SPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCF-ATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFA---INEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLR--IFIYYVGEEITPIDV-----LENRTCEYRGYF--GHIHAMGAVSNIIDKYSKTVHYHT-IHRENQMEDNEFRIDLVSVNEDGFHNPEDFPP---------MGLGLMTSLTMPVYNRSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIE 1675
            A  FA +  TK      IK   EV Y  S  +   +E        L     F+T+V  ++  V I          + + +  T K N   I  +  L +QYF S  G+   YP +R        +D R R WYV+ AS  PKDV++++D SGSM G  + + K A + ++DT+   D +A   F  G  +      D    + + CF ++  +AS  N D L K +    A G      A   A   +++++K  N T +         +I+  TD     D   I + +   N   + +  I  + +G  I+P  V     L  +T +    F      A+  VS  +   +++      + R   + D     + ++     F   ED  P         +GLGL+TS+T P Y++   G F+G+ GTD+ ++ +   V +   G+  YAF  +++G  + HP L       + P  +D+ ++E
Sbjct:   74 ATRFANKLQTKVTIARKIKDAVEVSYAKSATVTSRTECCKADTRWLKYDSRFRTKVNLDEMCVIISGAASSNPKQLQDNVLQTMKQN---IENNPTLTWQYFGSEEGLYTNYPMIR-DSSSCSSYDPRYRPWYVEAASPQPKDVILVVDYSGSMGGSRLPIAKEAAKTVLDTLNPRDRVAFLAFESGVRRVKVTSGD---AKDEKCFESSLAKASPVNIDILKKFLDGEYASGGTMYAIAFNAAFDILDKYYKEKNTTRR--------PVILFMTDGAPNDDPGTILNTVKTRNQGLSTKADILTFGMGGGISPAGVDLLQSLAEQTLDGGARFEVSLTTALRDVSRHLLAVARSARKLVQVGRYTPVTDVSNLRNRMATYYSAFSRKEDDKPIFSVPYVDTLGLGLLTSITFPCYHQ---GKFIGVAGTDVVMSELLADVTYFNQGQASYAFVADSSGRTMMHPLLPKPSDPYQAPFFLDIRDLE 541
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Nematostella
Match: EDO46979 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNR9])

HSP 1 Score: 84.7297 bits (208), Expect = 1.987e-16
Identity = 98/407 (24.08%), Postives = 171/407 (42.01%), Query Frame = 2 
Query:  560 IRASNNLRYQYFASFTGIVLQYPGMRWRKKGTDMFDVRRRQWYVQGAS-SPKDVMVLIDTSGSMH-------GIAIKLTKSAVEKLIDTMGENDYIAVTHFP-----PGKNQAMQLIKDYPFIQTKPCFA-TFVQASKRNKDRLFKQIFQLRAQG----IANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFI--YYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMED-NEFRIDLV-------SVNEDGFHNPEDFPP----MGLGLMTSLTMPVYNRSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDS 1684
            ++ S  L++QYF S  G+   YP     + G+  +D R R WYV  A+  PK+V++++D+SGSM           +++   A + ++DT+   D + V         PG N             T  C+A T  +A+  N + +   +  +R+ G    I  L  A    +N          K     +C+++I+  TD+     KE +   +  SN   + R+ I  Y +G E                 F  +  M   S     +       T     Q+ D    R ++V       S N+     P    P     GLGL+T++T+P Y+  GN +F+G++G D+T+  +   V +    +  YAF I+ +G  + HP L       +D  ++++  +E D+
Sbjct:  156 MKESPYLKWQYFGSVEGLTTIYPMQSQAECGS--YDNRARPWYVDAAAPKPKNVVLVVDSSGSMAEKHTANGKTWLQMAIDAAKAVLDTLNPRDKVGVVSLATDANTPGSN------------DTTWCYANTLAEANSVNINNMKIFLDGMRSAGFTMYIPALTKAFALLLN---------SKPESPDDCDQVIIFLTDAKPTELKESVMRTIVESNKLLDNRVVILAYGIGAED----------------FSFLGDMVRQSGYNQTWDPAAGQVTPGIWKQITDIGRLREEMVTYYNFFFSANDPSTAEPRIAVPYHDAWGLGLITTVTLPCYH--GN-TFVGVVGIDITMGDLLADVSYFGAEQESYAFVIDGSGRGLVHPLLPMPSNADQDYASLEIRTLEPDA 520
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Medaka
Match: cacna2d2a (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:NCBI gene;Acc:101155679])

HSP 1 Score: 284.648 bits (727), Expect = 1.477e-79
Identity = 191/620 (30.81%), Postives = 322/620 (51.94%), Query Frame = 2 
Query:  113 ENLQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLE----IAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK---DLPENSEL-------------LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYN------RSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNK 1882
            + ++ E +K +++     Q   + +IY+E  +K   E    NP +    +A+D S KL N  RK +E L R    AE+   ++ +   +   ++ Y +SK   D  E+ E               V  P FK +V  + S+V IPT+IYK    ILN L WTQ L  +FI   R  ++LR+Q F S TG+   YP   WR     D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    +  +            PCF T VQA+ RNK    + +  ++A+G  +  +   FA   F +  N T  G   ANCN++I++FTD G++  ++ I    N  N  K +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +    + +    ++   +V +D          +GLGL+ + TMPV+N       S N   LG++G D+ +  + +  P  +LG NGY FAI+ NGY++ HP L+ ++   R+P  +D  + E +   K +IR ++I+  +      G+  + +L+K  DE +  E  RTY++T V  + + + +V   Y++
Sbjct:   45 QRIEKELEKVLQHVTGTEQ---MKSIYNE--KKSQFEIKRNNPKDLVERVARDIS-KLLNSKRKALEKLARE---AEQLQKEHVWQDGVTENDISYYDSKADSDYMEDGEEEIPTEISSSLELEFVPDPNFKNKVNYSSSAVQIPTDIYKGSPVILNELNWTQALERVFIENRREDSSLRWQVFGSATGVTRYYPATPWRAPNKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVMEMLDTLSDDDYVNVARFNEKADAVV------------PCFKTLVQANVRNKKIFKEAVMHMQAKGTTDYKSGFTFA---FEQLLNET--GAPRANCNKMIMMFTDGGEDRAQD-IFEKYNWPN--KTVRVFTFSVGQHNYDVTPLQWIACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGPKAK----QVQWTNVYQDA---------LGLGLVITGTMPVFNLTADSVSSQNQLILGVMGVDVAINEIKKKTPTYRLGANGYTFAIDPNGYVLLHPNLQPKIINFREPVTLDFLDAELEDTNKEEIRRQMIDGKS------GQRKIRTLVKSVDERYIDEVVRTYTWTPVEGTNYSLGLVLPTYSE 616

HSP 2 Score: 66.2402 bits (160), Expect = 2.032e-10
Identity = 64/270 (23.70%), Postives = 123/270 (45.56%), Query Frame = 2 
Query: 2267 ETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEK-VEKFLKRSD----SLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKY---------------------------EACNKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEE 2980
            E  +SN +  T+F +  I ++  +   S  +C +     LI D  ++ + VEK  +  D       +V  +T  G++ V P      +++  +   N+T ++R+ D   +IF   +     + E  N  N++   L V  + ++ +    + P AV+G+   +L L +  +K+                           EA ++  LCYL++DG ++I  N K  +++VG FFG +   +M  L NNS +   + +DYQ++C +  + E
Sbjct:  657 ELELSNNN--TEFLLNFISLMEKVTPDSK-QCDNLLLHNLILDTGIIRQLVEKVWRNKDLNTYGFLAVFAATDGGITRVFPNKAAETWEEDPEP-FNATYYRRSLDNSGYIFRAPYRTS--RDELLNPENDTIGIL-VSTALNLAVGGKTIKP-AVVGV---KLDLEAWTEKFKILASNQTDSRQGSNTCGPNKGCEMDCEANSEDLLCYLVDDGAFLIMSNQKDYVNRVGMFFGDVDSYLMYALYNNSFYNRKQSYDYQSVCERLTNSE 915
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Medaka
Match: cacna2d2a (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:NCBI gene;Acc:101155679])

HSP 1 Score: 284.648 bits (727), Expect = 2.035e-79
Identity = 188/605 (31.07%), Postives = 320/605 (52.89%), Query Frame = 2 
Query:  113 ENLQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLE----IAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSEL-LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYN------RSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNK 1882
            + ++ E +K +++     Q   + +IY+E  +K   E    NP +    +A+D S KL N  RK +E L R    AE+   ++ +   +  E+ +     ++  + EL  V  P FK +V  + S+V IPT+IYK    ILN L WTQ L  +FI   R  ++LR+Q F S TG+   YP   WR     D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    +  +            PCF T VQA+ RNK    + +  ++A+G  +  +   FA   F +  N T  G   ANCN++I++FTD G++  ++ I    N  N  K +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +    + +    ++   +V +D          +GLGL+ + TMPV+N       S N   LG++G D+ +  + +  P  +LG NGY FAI+ NGY++ HP L+ ++   R+P  +D  + E +   K +IR ++I+  +      G+  + +L+K  DE +  E  RTY++T V  + + + +V   Y++
Sbjct:   45 QRIEKELEKVLQHVTGTEQ---MKSIYNE--KKSQFEIKRNNPKDLVERVARDIS-KLLNSKRKALEKLARE---AEQLQKEHVWQDGVTMEDGEEEIPTEISSSLELEFVPDPNFKNKVNYSSSAVQIPTDIYKGSPVILNELNWTQALERVFIENRREDSSLRWQVFGSATGVTRYYPATPWRAPNKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVMEMLDTLSDDDYVNVARFNEKADAVV------------PCFKTLVQANVRNKKIFKEAVMHMQAKGTTDYKSGFTFA---FEQLLNET--GAPRANCNKMIMMFTDGGEDRAQD-IFEKYNWPN--KTVRVFTFSVGQHNYDVTPLQWIACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGPKAK----QVQWTNVYQDA---------LGLGLVITGTMPVFNLTADSVSSQNQLILGVMGVDVAINEIKKKTPTYRLGANGYTFAIDPNGYVLLHPNLQPKIINFREPVTLDFLDAELEDTNKEEIRRQMIDGKS------GQRKIRTLVKSVDERYIDEVVRTYTWTPVEGTNYSLGLVLPTYSE 601

HSP 2 Score: 88.5817 bits (218), Expect = 2.829e-17
Identity = 106/443 (23.93%), Postives = 190/443 (42.89%), Query Frame = 2 
Query: 2267 ETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEK-VEKFLKRSD----SLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKY---------------------------EACNKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHF--SSAQEATATDNKNISCIKKYHRFYFN--ESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYP---IKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKC 3478
            E  +SN +  T+F +  I ++  +   S  +C +     LI D  ++ + VEK  +  D       +V  +T  G++ V P      +++  +   N+T ++R+ D   +IF   +     + E  N  N++   L V  + ++ +    + P AV+G+   +L L +  +K+                           EA ++  LCYL++DG ++I  N K  +++VG FFG +   +M  L NNS +   + +DYQ++C +  + E  ++   +   T    + +        +     LF ++L  LA   +  +    A   D+K  SC+    +FY     SS N     I Q C NC+  I+  R+N +NL+ V  ++  C     Y  +  R      +    + C+  N  RYR RP   C+  N  EN   C
Sbjct:  642 ELELSNNN--TEFLLNFISLMEKVTPDSK-QCDNLLLHNLILDTGIIRQLVEKVWRNKDLNTYGFLAVFAATDGGITRVFPNKAAETWEEDPEP-FNATYYRRSLDNSGYIFRAPYRTS--RDELLNPENDTIGIL-VSTALNLAVGGKTIKP-AVVGV---KLDLEAWTEKFKILASNQTDSRQGSNTCGPNKGCEMDCEANSEDLLCYLVDDGAFLIMSNQKDYVNRVGMFFGDVDSYLMYALYNNSFYNRKQSYDYQSVCERLTNSEAGAAPRGVFVPTVADFLNLAWWTSAAAW----SLFQQVLYGLAHNSWFITDKVNAEGLDSKERSCVTIQTQFYMTNLSSSYN-----ILQDCGNCSRLIHARRINNTNLLFVVAEKMPC-----YTCEIERLSQEEEEFKEENPCESINVARYRKRPSM-CFDNNLAENTSDC 1058
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Medaka
Match: cacna2d2a (calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Source:NCBI gene;Acc:101155679])

HSP 1 Score: 285.034 bits (728), Expect = 2.296e-79
Identity = 191/620 (30.81%), Postives = 322/620 (51.94%), Query Frame = 2 
Query:  113 ENLQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLE----IAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK---DLPENSEL-------------LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYN------RSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNK 1882
            + ++ E +K +++     Q   + +IY+E  +K   E    NP +    +A+D S KL N  RK +E L R    AE+   ++ +   +   ++ Y +SK   D  E+ E               V  P FK +V  + S+V IPT+IYK    ILN L WTQ L  +FI   R  ++LR+Q F S TG+   YP   WR     D++DVRRR WY+QGASSPKD+++++D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    +  +            PCF T VQA+ RNK    + +  ++A+G  +  +   FA   F +  N T  G   ANCN++I++FTD G++  ++ I    N  N  K +R+F + VG+    +  L+   C  +GY+  I ++GA+     +Y   +    +    + +    ++   +V +D          +GLGL+ + TMPV+N       S N   LG++G D+ +  + +  P  +LG NGY FAI+ NGY++ HP L+ ++   R+P  +D  + E +   K +IR ++I+  +      G+  + +L+K  DE +  E  RTY++T V  + + + +V   Y++
Sbjct:   45 QRIEKELEKVLQHVTGTEQ---MKSIYNE--KKSQFEIKRNNPKDLVERVARDIS-KLLNSKRKALEKLARE---AEQLQKEHVWQDGVTENDISYYDSKADSDYMEDGEEEIPTEISSSLELEFVPDPNFKNKVNYSSSAVQIPTDIYKGSPVILNELNWTQALERVFIENRREDSSLRWQVFGSATGVTRYYPATPWRAPNKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVMEMLDTLSDDDYVNVARFNEKADAVV------------PCFKTLVQANVRNKKIFKEAVMHMQAKGTTDYKSGFTFA---FEQLLNET--GAPRANCNKMIMMFTDGGEDRAQD-IFEKYNWPN--KTVRVFTFSVGQHNYDVTPLQWIACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGPKAK----QVQWTNVYQDA---------LGLGLVITGTMPVFNLTADSVSSQNQLILGVMGVDVAINEIKKKTPTYRLGANGYTFAIDPNGYVLLHPNLQPKIINFREPVTLDFLDAELEDTNKEEIRRQMIDGKS------GQRKIRTLVKSVDERYIDEVVRTYTWTPVEGTNYSLGLVLPTYSE 616

HSP 2 Score: 88.9669 bits (219), Expect = 2.284e-17
Identity = 106/443 (23.93%), Postives = 190/443 (42.89%), Query Frame = 2 
Query: 2267 ETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEK-VEKFLKRSD----SLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKY---------------------------EACNKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHF--SSAQEATATDNKNISCIKKYHRFYFN--ESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYP---IKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKC 3478
            E  +SN +  T+F +  I ++  +   S  +C +     LI D  ++ + VEK  +  D       +V  +T  G++ V P      +++  +   N+T ++R+ D   +IF   +     + E  N  N++   L V  + ++ +    + P AV+G+   +L L +  +K+                           EA ++  LCYL++DG ++I  N K  +++VG FFG +   +M  L NNS +   + +DYQ++C +  + E  ++   +   T    + +        +     LF ++L  LA   +  +    A   D+K  SC+    +FY     SS N     I Q C NC+  I+  R+N +NL+ V  ++  C     Y  +  R      +    + C+  N  RYR RP   C+  N  EN   C
Sbjct:  657 ELELSNNN--TEFLLNFISLMEKVTPDSK-QCDNLLLHNLILDTGIIRQLVEKVWRNKDLNTYGFLAVFAATDGGITRVFPNKAAETWEEDPEP-FNATYYRRSLDNSGYIFRAPYRTS--RDELLNPENDTIGIL-VSTALNLAVGGKTIKP-AVVGV---KLDLEAWTEKFKILASNQTDSRQGSNTCGPNKGCEMDCEANSEDLLCYLVDDGAFLIMSNQKDYVNRVGMFFGDVDSYLMYALYNNSFYNRKQSYDYQSVCERLTNSEAGAAPRGVFVPTVADFLNLAWWTSAAAW----SLFQQVLYGLAHNSWFITDKVNAEGLDSKERSCVTIQTQFYMTNLSSSYN-----ILQDCGNCSRLIHARRINNTNLLFVVAEKMPC-----YTCEIERLSQEEEEFKEENPCESINVARYRKRPSM-CFDNNLAENTSDC 1073
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Medaka
Match: cacna2d2b (voltage-dependent calcium channel subunit alpha-2/delta-2 [Source:NCBI gene;Acc:101156079])

HSP 1 Score: 270.396 bits (690), Expect = 1.598e-74
Identity = 182/621 (29.31%), Postives = 316/621 (50.89%), Query Frame = 2 
Query:   98 ILSSLENLQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSK-DL-------------PENSEL-LVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFI---RASNNLRYQYFASFTGIVLQYPGMRWRKKG-TDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGS-----FLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            I+     ++ E D+  ++   V Q   +  IY+E  ++        +P  I +  +  +     KK ++L+R    AE    ++ +   IK  ++ Y +SK DL             P + +L  V  P FK  V  + ++V IPT+IYK    ILN L WTQ L  +F+   R   +L +Q F S TG+   YP   W+     D++DVRRR WY+QGASSPKD+++L+D SGS+ G+ +KL K++V +++DT+ ++DY+ V  F    N+  + +         PCF   VQA+ RNK    + + Q++A+G  +  +   FA N+     N        ANCN++I++FTD G++  ++     M  +   K +R+F + VG+    +  L+   C  +GY+  I ++ A+     +Y   +    +   ++ +    ++   +V +D          +GLG++ + T+PV+N + NG+      LG++G D+ +  +  L P   LG NGY FAI+ NGY++ HP L+ +L  + +P  +D  + E + + K +IR ++I+         GE  V + IK  DE +  E  R Y++T +  + + + +V   YN+YY
Sbjct:   40 IMHWARRIEQEIDRVFQHITGVQQ---LKGIYNE--ERRRFSVLKNHPRRIVEKVALDIERLLAKKRKALERLASEAERLQQEHLWQDGIKELDMAYYDSKADLDYYSMDGEGEVENPSHIKLEFVYDPNFKNNVNYSYTAVQIPTDIYKGAPVILNELNWTQALEKVFMENSREDPSLLWQAFGSATGVTRYYPATPWKTPDKIDLYDVRRRPWYIQGASSPKDMVILVDVSGSVSGLTLKLIKASVMEMLDTLSDDDYVNVARF----NEKAEAV--------VPCFKHLVQANVRNKKIFKEAVQQMQAKGTTDYKSGFHFAFNQLLNKTNVPR-----ANCNKIIMLFTDGGEDRAQD---VFMQYNWPNKTVRVFTFSVGQHNYDVTPLQWIACANKGYYFEIRSICAIRINTQEYLDVLGRPMVLAGSEAK----QVQWTNVYQDA---------LGLGMVVTGTLPVFNLTMNGNTKNQLILGVMGVDVHLDEIKRLTPRYSLGANGYIFAIDPNGYLLLHPNLQPKLVNLPEPVTLDFLDAEVEDNNKEEIRRQMIDGRP------GEMQVKTFIKSIDEQYMDEVYRGYTWTPINDTDYSLGLVLPLYNEYY 616

HSP 2 Score: 78.9518 bits (193), Expect = 2.468e-14
Identity = 60/240 (25.00%), Postives = 108/240 (45.00%), Query Frame = 2 
Query: 2792 LCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEE---------IXXXXXXXXXXXXXXXIPVVICKKILF-YLENIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN 3481
            LCYLI+DGG+++  N +    ++G FFG + P +M  L NNSIF   + F YQ+ C                + S +  L       S+   + +++L+  + N +L+  +L++             + + K  SC+    +FYF  ++ NS    + Q C NC+   +  R+  +NL+ V  +   C +         R   ++  P  C++ +  RYR  P   C+ ++  EN  +C 
Sbjct:  851 LCYLIDDGGFLVMSNQRDHWKKIGLFFGDVDPNLMHALYNNSIFARRQTFQYQSACEPVSSSHTGAATRGIFVPSVADLLSLAWWTSSVAWSVIQQLLYGVVYNSWLYQDVLVE-------------SFETKESSCVTIQSQFYFTNTT-NSY--NVLQDCGNCSRLFHAKRIEGTNLLFVVAETLSCGSCEIERLTQVRTEFQEENP--CEVLSNARYRKGPT-SCFDYSALENTSECG 1071
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Medaka
Match: cacna2d1a (voltage-dependent calcium channel subunit alpha-2/delta-1 [Source:NCBI gene;Acc:101156213])

HSP 1 Score: 266.544 bits (680), Expect = 2.820e-73
Identity = 179/617 (29.01%), Postives = 314/617 (50.89%), Query Frame = 2 
Query:   95 DILSSLENLQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDF------AEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASN---NLRYQYFASFTGIVLQYPGMRWRKKGT-----DMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYN-----RSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYY 1888
            D  S LENL   + K  +  FSV        + +     G IE    N  +  K  + + A +F+K+ +  +++ D       A++   K +++   K E+   + ++ +P++     D   FK RV  N ++VHIPT+IY+  + ILN L WT  L ++F +      +L +Q F S TG+   YP   W    +     D++DVRRR WY+QGA+SPKD+++L+D SGS+ G+ +KL K++V K+++T+ ++D++ V  F    N++ + +          CF   VQA+ RNK  L   + +++A+GI N  +  E A      F    +     A+CNR+I++FTD G+    EK   ++ + N  + +RIF + VG+       ++   C  +GY+  I ++GA+     +Y   +    +  + + +    ++   +V  D          + LGL+ + T+PV+N     +S N   LG++  D+++  +  L P    G NGY FAI+ NGY++ HP L+       +P  +D  + E ++D K +IR ++I+ +       GE  V +L+K  DE +  +  RTY++  V  + + + +V   YNKYY
Sbjct:   44 DTASGLENLIKIYHKH-KTHFSVESNNARQLVAT---ASGNIEKLLDNRSQALKRLATE-AEKFQKEHQWTEKSEDNKIFYYNAKDGTNKTEFEEKQKGEDGDELKNRFIPDDFTNETDEN-FKRRVSFNTTAVHIPTDIYEGSTIILNELNWTDALEDVFRKNREEDPSLLWQVFGSATGLARYYPASPWTDSSSSPDKIDLYDVRRRPWYIQGAASPKDMLILVDASGSVSGLTLKLIKTSVHKMLETLSDDDFVNVVSF----NKSARPVA---------CFEHLVQANVRNKRVLKDAVQRIKAEGITNYTSGFELA------FAQLAQTNVSRADCNRIIMLFTDGGE----EKAEEILEKLNKNREVRIFTFSVGQHSYDKGPVQWMACTNKGYYYEIPSIGAIRLNTQEYLDVLGRPMVKADRKAK----QVQWTNVYLDA---------LDLGLVITGTLPVFNKTDSKKSPNQLILGVMAIDVSLEDIKRLTPRFTFGPNGYYFAIDPNGYVLLHPNLQPMTARFDEPVTLDFLDAELENDIKVQIRKEMIDRST------GEYTVNTLVKSQDERYIDQGQRTYTFGPVKGTDYSLALVLPDYNKYY 612

HSP 2 Score: 87.4261 bits (215), Expect = 6.013e-17
Identity = 90/403 (22.33%), Postives = 183/403 (45.41%), Query Frame = 2 
Query: 2351 DDKCPHYESRRLITDLYVLEKVEKFLKRSD---SLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSN-NNSFPDLKVFKSFSVTMKPDHVI-PIAVLGLSLK-QLPLVSIMQ-------KYEAC-----NKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAIC-PKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATATDNK------NISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNS 3484
            D +C      RL+ D  +   + K  K+S+    + +V ++T  G++ V P+S    + +  + +  S+ ++R+ + + +IF           +P N N ++S  D  +  S +V +K   V+   AV+G+ L  +  + S+M        K E C     N    C +++DGG+++  N ++ + ++G+FFG I P +M  L+N+S++ S   +DYQ++C PK   ++              + +P +     L +      +  L   +  I + S  +A   ++K         CI +  ++YF E+  ++    +   C NC+      ++  +NL+ +  D     ++C  +++  +   +  GP+ C+++  PRYR  P   C+  N  E    C  
Sbjct:  678 DPECNVELMNRLLLDAGITADLIKIWKKSELPNGVKAVFVATDGGITRVYPESAGMEWNEEVETY-ESSFYKRSLENDLYIF---------TPKPYNKNLSSSESDESILASKAVDLKIGEVLLKPAVVGVKLDIKAWMNSLMNTTTTINCKDEICGCRINNAYIDCIVLDDGGFLVMSNQEEYIKEIGNFFGVIDPTIMRALVNDSLYTSKSTYDYQSLCDPKRTSKK--------AAGPRSVYVPTIADILNLGWWATAAAWSVLQQLMVSITYPSFLDAVDVEDKMPDSMTKEVCITEQTQYYF-ENKRSTFSGSV--DCGNCSRLFLAEKLPKTNLVFIIADAKGTCSSC-VSSKLIQEEQQSDGPNPCEMALSPRYRKGP--ACFDKNQPEKDADCGG 1056
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Planmine SMEST
Match: SMESG000021966.1 (SMESG000021966.1)

HSP 1 Score: 2330.44 bits (6038), Expect = 0.000e+0
Identity = 1156/1156 (100.00%), Postives = 1156/1156 (100.00%), Query Frame = 2 
Query:   80 KQMKMDILSSLENLQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASNNLRYQYFASFTGIVLQYPGMRWRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYYPVFSQDIKLIKLLECSHVHCSMVVSLPSDLNSQLQFTNDIFVYAELGLIGKCKIIKDNXXXXXXXXXXXXXXXXXXRQYSETKRRKIEKTAAQIVPLGSMDSSMANTISAIQSFNISTNPSVIRDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEKVEKFLKRSDSLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYEACNKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNSDKLDYFISTTRLFTFILATTC 3547
            KQMKMDILSSLENLQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASNNLRYQYFASFTGIVLQYPGMRWRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYYPVFSQDIKLIKLLECSHVHCSMVVSLPSDLNSQLQFTNDIFVYAELGLIGKCKIIKDNFSFSSTTTTTTTQQTSSTRQYSETKRRKIEKTAAQIVPLGSMDSSMANTISAIQSFNISTNPSVIRDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEKVEKFLKRSDSLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYEACNKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEISSSSSRLKPLTTLLSIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNSDKLDYFISTTRLFTFILATTC
Sbjct:   17 KQMKMDILSSLENLQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASNNLRYQYFASFTGIVLQYPGMRWRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYYPVFSQDIKLIKLLECSHVHCSMVVSLPSDLNSQLQFTNDIFVYAELGLIGKCKIIKDNFSFSSTTTTTTTQQTSSTRQYSETKRRKIEKTAAQIVPLGSMDSSMANTISAIQSFNISTNPSVIRDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEKVEKFLKRSDSLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYEACNKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEISSSSSRLKPLTTLLSIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNSDKLDYFISTTRLFTFILATTC 1172
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Planmine SMEST
Match: SMESG000021966.1 (SMESG000021966.1)

HSP 1 Score: 2328.13 bits (6032), Expect = 0.000e+0
Identity = 1154/1154 (100.00%), Postives = 1154/1154 (100.00%), Query Frame = 2 
Query:   86 MKMDILSSLENLQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASNNLRYQYFASFTGIVLQYPGMRWRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYYPVFSQDIKLIKLLECSHVHCSMVVSLPSDLNSQLQFTNDIFVYAELGLIGKCKIIKDNXXXXXXXXXXXXXXXXXXRQYSETKRRKIEKTAAQIVPLGSMDSSMANTISAIQSFNISTNPSVIRDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEKVEKFLKRSDSLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYEACNKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEIXXXXXXXXXXXXXXXIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNSDKLDYFISTTRLFTFILATTC 3547
            MKMDILSSLENLQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASNNLRYQYFASFTGIVLQYPGMRWRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYYPVFSQDIKLIKLLECSHVHCSMVVSLPSDLNSQLQFTNDIFVYAELGLIGKCKIIKDNFSFSSTTTTTTTQQTSSTRQYSETKRRKIEKTAAQIVPLGSMDSSMANTISAIQSFNISTNPSVIRDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEKVEKFLKRSDSLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYEACNKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEISSSSSRLKPLTTLLSIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNSDKLDYFISTTRLFTFILATTC
Sbjct:    1 MKMDILSSLENLQMEFDKFMRNQFSVFQEPTIANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAEEEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVHIPTEIYKEDSFILNTLKWTQKLNNIFIRASNNLRYQYFASFTGIVLQYPGMRWRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVSVNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFDSDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTGVPYSTFGITIVNSKYNKYYPVFSQDIKLIKLLECSHVHCSMVVSLPSDLNSQLQFTNDIFVYAELGLIGKCKIIKDNFSFSSTTTTTTTQQTSSTRQYSETKRRKIEKTAAQIVPLGSMDSSMANTISAIQSFNISTNPSVIRDKETNISNGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEKVEKFLKRSDSLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKFIFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLSLKQLPLVSIMQKYEACNKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICPKEKDEEISSSSSRLKPLTTLLSIPVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKYHRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSNNCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCNSDKLDYFISTTRLFTFILATTC 1154
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Planmine SMEST
Match: SMESG000020648.1 (SMESG000020648.1)

HSP 1 Score: 150.984 bits (380), Expect = 1.487e-36
Identity = 155/672 (23.07%), Postives = 278/672 (41.37%), Query Frame = 2 
Query:  233 VNPLEIAKDFSNKLANEFRKKMESLKRAV-----DFAEEEATKYQYDPHIKPEEVQYINSKDLPENSE----------LLVDHPLFKTRVIANQ--SSVHIPTEIYKEDSFILNTLKWTQKLNNIFI--RASNNLRYQYFASFTGIVLQYPGMRWR---------KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQLR-AQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVH------------YHTIHRENQMEDNEFRIDLVSVNEDG-----FHNPE----------------------------DFPPMGLG-----------LMTSLTMPVYNRSG------NGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFH----PELKNQLGWMRDPPNVDLTEIEFDS---DEKTKIRS----------KIINCAASNGTEYGEDDVISLIKVSDEIHT-YEKSRTYSYTGVPYST--FGITIVNSKYNKYYPVFSQDIKL 1915
            +N L+ +K  S K+ N+    ++ L++ +     ++++  + KY+ D  +    + Y  +K L  +S           L +D   +   ++ N+  S+ H+PT +Y     I +   WT  L+  F   +  + L++Q+F S TG+   YPG+RW              D FD R  QWY++  S PK +M+++D SGSM G    +    + ++++T+ END+  +  F           K+Y F          +QA+ +NK  +  Q+  +    GIA  D  L      F    N      +    N L+++ TD G   D ++   L+   N     RIF Y +G+  T  +++ N  C+ +GY   I  +  V   + KY   V             +  +H+ NQM+  E  +  +S N D        NP                             + PP+ +            L  + +  VY+ +       +G  LG  G D+ +    +  P  K+G N Y F + +NG+++FH    P+ K  + +     NVD++E+E DS   D  T IR+          ++         +  E   ++  ++ D+  T ++  RTY   G+  ++  FG+ +     N+  P +S +I L
Sbjct:   68 INILQTSKADSEKIVNKTNIVVDILQQKLTQAFNEYSQTPSKKYRLDCVVNDSFIFYFRAKALRASSSVNETNCNIQTLPLDKDPYLGNIVTNREMSTTHVPTNVYDASQEIQSVANWTADLDQTFQMRKDDSQLKWQFFCSNTGLFKIYPGIRWNLQIEDSDRDSSLVDFFDCRSEQWYLEATSYPKKMMIMVDKSGSMKGRRKIIANHTIYEILNTLTENDFFNILLFT----------KEYCFADNYTS-GILMQATDKNKKYILDQLATVFIPDGIAEYDFGL---TESFKVLRNDKMNDTDSKYYNYLLMIITD-GSPLDYQQ---LIENYNKDLGARIFTYLIGQGTTEREMVTNMACKNQGYAVEIATLADVKENVQKYLNVVARKNALMRNAFNVWTGVHK-NQMQPTEEIV--ISNNTDTTFMPMIMNPSASSVTFAPNITTTFATSTTRSLLSNTTVNIPPIQMTKIEIFEDKPIELFVTASKAVYDETNETAALKSGILLGAAGVDVPINEFIKTAPFWKIGVNAYLFGVTSNGFVLFHPKYAPQYKKHVKYFYR--NVDISELEIDSEATDNITFIRNDQTVQAGKTDQLRKSLIDQKDQVKEAGSLTTFQILDDFKTVFKVERTYFIAGIKDTSYKFGLAV---PLNQMVPNYSDEISL 713

HSP 2 Score: 53.5286 bits (127), Expect = 1.015e-6
Identity = 28/86 (32.56%), Postives = 49/86 (56.98%), Query Frame = 2 
Query: 2711 IAVLGLSLKQLPLVSIMQKYEACNKTRL--CYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICP 2962
            + V+G+  K    ++++ K   CN T    CY++ + G ++ +N+  L H  G    +I   +M+ L++N IFKS   FD+QA+CP
Sbjct:  911 LGVIGIQAKYNDFLAVLMKDALCNNTLQYDCYVLTESGLIL-LNNMDLRHN-GDLLTEIDCALMETLVHNKIFKSQSVFDFQALCP 994
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Planmine SMEST
Match: SMESG000020648.1 (SMESG000020648.1)

HSP 1 Score: 150.214 bits (378), Expect = 2.579e-36
Identity = 155/672 (23.07%), Postives = 278/672 (41.37%), Query Frame = 2 
Query:  233 VNPLEIAKDFSNKLANEFRKKMESLKRAV-----DFAEEEATKYQYDPHIKPEEVQYINSKDLPENSE----------LLVDHPLFKTRVIANQ--SSVHIPTEIYKEDSFILNTLKWTQKLNNIFI--RASNNLRYQYFASFTGIVLQYPGMRWR---------KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQL-RAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVH------------YHTIHRENQMEDNEFRIDLVSVNEDG-----FHNPE----------------------------DFPPMGLG-----------LMTSLTMPVYNRSG------NGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFH----PELKNQLGWMRDPPNVDLTEIEFDS---DEKTKIRS----------KIINCAASNGTEYGEDDVISLIKVSDEIHT-YEKSRTYSYTGVPYST--FGITIVNSKYNKYYPVFSQDIKL 1915
            +N L+ +K  S K+ N+    ++ L++ +     ++++  + KY+ D  +    + Y  +K L  +S           L +D   +   ++ N+  S+ H+PT +Y     I +   WT  L+  F   +  + L++Q+F S TG+   YPG+RW              D FD R  QWY++  S PK +M+++D SGSM G    +    + ++++T+ END+  +  F           K+Y F          +QA+ +NK  +  Q+  +    GIA  D  L      F    N      +    N L+++ TD G   D ++   L+   N     RIF Y +G+  T  +++ N  C+ +GY   I  +  V   + KY   V             +  +H+ NQM+  E  +  +S N D        NP                             + PP+ +            L  + +  VY+ +       +G  LG  G D+ +    +  P  K+G N Y F + +NG+++FH    P+ K  + +     NVD++E+E DS   D  T IR+          ++         +  E   ++  ++ D+  T ++  RTY   G+  ++  FG+ +     N+  P +S +I L
Sbjct:   68 INILQTSKADSEKIVNKTNIVVDILQQKLTQAFNEYSQTPSKKYRLDCVVNDSFIFYFRAKALRASSSVNETNCNIQTLPLDKDPYLGNIVTNREMSTTHVPTNVYDASQEIQSVANWTADLDQTFQMRKDDSQLKWQFFCSNTGLFKIYPGIRWNLQIEDSDRDSSLVDFFDCRSEQWYLEATSYPKKMMIMVDKSGSMKGRRKIIANHTIYEILNTLTENDFFNILLF----------TKEYCFADNYTS-GILMQATDKNKKYILDQLATVFIPDGIAEYDFGL---TESFKVLRNDKMNDTDSKYYNYLLMIITD-GSPLDYQQ---LIENYNKDLGARIFTYLIGQGTTEREMVTNMACKNQGYAVEIATLADVKENVQKYLNVVARKNALMRNAFNVWTGVHK-NQMQPTEEIV--ISNNTDTTFMPMIMNPSASSVTFAPNITTTFATSTTRSLLSNTTVNIPPIQMTKIEIFEDKPIELFVTASKAVYDETNETAALKSGILLGAAGVDVPINEFIKTAPFWKIGVNAYLFGVTSNGFVLFHPKYAPQYKKHVKYFYR--NVDISELEIDSEATDNITFIRNDQTVQAGKTDQLRKSLIDQKDQVKEAGSLTTFQILDDFKTVFKVERTYFIAGIKDTSYKFGLAV---PLNQMVPNYSDEISL 713

HSP 2 Score: 53.9138 bits (128), Expect = 9.892e-7
Identity = 28/86 (32.56%), Postives = 49/86 (56.98%), Query Frame = 2 
Query: 2711 IAVLGLSLKQLPLVSIMQKYEACNKTRL--CYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICP 2962
            + V+G+  K    ++++ K   CN T    CY++ + G ++ +N+  L H  G    +I   +M+ L++N IFKS   FD+QA+CP
Sbjct:  911 LGVIGIQAKYNDFLAVLMKDALCNNTLQYDCYVLTESGLIL-LNNMDLRHN-GDLLTEIDCALMETLVHNKIFKSQSVFDFQALCP 994
[Close]
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Planmine SMEST
Match: SMESG000020648.1 (SMESG000020648.1)

HSP 1 Score: 149.828 bits (377), Expect = 3.973e-36
Identity = 155/672 (23.07%), Postives = 278/672 (41.37%), Query Frame = 2 
Query:  233 VNPLEIAKDFSNKLANEFRKKMESLKRAV-----DFAEEEATKYQYDPHIKPEEVQYINSKDLPENSE----------LLVDHPLFKTRVIANQ--SSVHIPTEIYKEDSFILNTLKWTQKLNNIFI--RASNNLRYQYFASFTGIVLQYPGMRWR---------KKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSAVEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASKRNKDRLFKQIFQL-RAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNRLIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENRTCEYRGYFGHIHAMGAVSNIIDKYSKTVH------------YHTIHRENQMEDNEFRIDLVSVNEDG-----FHNPE----------------------------DFPPMGLG-----------LMTSLTMPVYNRSG------NGSFLGLLGTDMTVAFMDELVPHDKLGRNGYAFAINTNGYIIFH----PELKNQLGWMRDPPNVDLTEIEFDS---DEKTKIRS----------KIINCAASNGTEYGEDDVISLIKVSDEIHT-YEKSRTYSYTGVPYST--FGITIVNSKYNKYYPVFSQDIKL 1915
            +N L+ +K  S K+ N+    ++ L++ +     ++++  + KY+ D  +    + Y  +K L  +S           L +D   +   ++ N+  S+ H+PT +Y     I +   WT  L+  F   +  + L++Q+F S TG+   YPG+RW              D FD R  QWY++  S PK +M+++D SGSM G    +    + ++++T+ END+  +  F           K+Y F          +QA+ +NK  +  Q+  +    GIA  D  L      F    N      +    N L+++ TD G   D ++   L+   N     RIF Y +G+  T  +++ N  C+ +GY   I  +  V   + KY   V             +  +H+ NQM+  E  +  +S N D        NP                             + PP+ +            L  + +  VY+ +       +G  LG  G D+ +    +  P  K+G N Y F + +NG+++FH    P+ K  + +     NVD++E+E DS   D  T IR+          ++         +  E   ++  ++ D+  T ++  RTY   G+  ++  FG+ +     N+  P +S +I L
Sbjct:   68 INILQTSKADSEKIVNKTNIVVDILQQKLTQAFNEYSQTPSKKYRLDCVVNDSFIFYFRAKALRASSSVNETNCNIQTLPLDKDPYLGNIVTNREMSTTHVPTNVYDASQEIQSVANWTADLDQTFQMRKDDSQLKWQFFCSNTGLFKIYPGIRWNLQIEDSDRDSSLVDFFDCRSEQWYLEATSYPKKMMIMVDKSGSMKGRRKIIANHTIYEILNTLTENDFFNILLF----------TKEYCFADNYTS-GILMQATDKNKKYILDQLATVFIPDGIAEYDFGL---TESFKVLRNDKMNDTDSKYYNYLLMIITD-GSPLDYQQ---LIENYNKDLGARIFTYLIGQGTTEREMVTNMACKNQGYAVEIATLADVKENVQKYLNVVARKNALMRNAFNVWTGVHK-NQMQPTEEIV--ISNNTDTTFMPMIMNPSASSVTFAPNITTTFATSTTRSLLSNTTVNIPPIQMTKIEIFEDKPIELFVTASKAVYDETNETAALKSGILLGAAGVDVPINEFIKTAPFWKIGVNAYLFGVTSNGFVLFHPKYAPQYKKHVKYFYR--NVDISELEIDSEATDNITFIRNDQTVQAGKTDQLRKSLIDQKDQVKEAGSLTTFQILDDFKTVFKVERTYFIAGIKDTSYKFGLAV---PLNQMVPNYSDEISL 713

HSP 2 Score: 53.5286 bits (127), Expect = 1.053e-6
Identity = 28/86 (32.56%), Postives = 49/86 (56.98%), Query Frame = 2 
Query: 2711 IAVLGLSLKQLPLVSIMQKYEACNKTRL--CYLIEDGGYVISVNDKKLLHQVGSFFGQISPLVMDILINNSIFKSIEDFDYQAICP 2962
            + V+G+  K    ++++ K   CN T    CY++ + G ++ +N+  L H  G    +I   +M+ L++N IFKS   FD+QA+CP
Sbjct:  911 LGVIGIQAKYNDFLAVLMKDALCNNTLQYDCYVLTESGLIL-LNNMDLRHN-GDLLTEIDCALMETLVHNKIFKSQSVFDFQALCP 994
The following BLAST results are available for this feature:
BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CACNA2D23.280e-7929.52calcium voltage-gated channel auxiliary subunit al... [more]
CACNA2D25.831e-7929.52calcium voltage-gated channel auxiliary subunit al... [more]
CACNA2D27.299e-7929.52calcium voltage-gated channel auxiliary subunit al... [more]
CACNA2D27.650e-7929.52calcium voltage-gated channel auxiliary subunit al... [more]
CACNA2D29.135e-7929.52calcium voltage-gated channel auxiliary subunit al... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4
Match NameE-valueIdentityDescription
unc-361.491e-2823.24Voltage-dependent calcium channel unc-36 [Source:... [more]
tag-1809.036e-2422.52pep chromosome:WBcel235:II:11323051:11329147:-1 ge... [more]
tag-1809.191e-2422.52pep chromosome:WBcel235:II:11323051:11329429:-1 ge... [more]
unc-361.974e-2321.51Voltage-dependent calcium channel unc-36 [Source:... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
stj5.781e-5127.66gene:FBgn0261041 transcript:FBtr0087631[more]
Ca-Ma2d5.181e-4928.29gene:FBgn0261999 transcript:FBtr0303797[more]
Ca-Ma2d5.181e-4928.29gene:FBgn0261999 transcript:FBtr0332356[more]
stj9.125e-4926.77gene:FBgn0261041 transcript:FBtr0304694[more]
stj1.453e-4826.73gene:FBgn0261041 transcript:FBtr0304695[more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cacna2d2b8.275e-7730.89calcium channel, voltage-dependent, alpha 2/delta ... [more]
cacna2d2b6.123e-7430.44calcium channel, voltage-dependent, alpha 2/delta ... [more]
CACNA2D14.493e-6828.67si:dkey-266j7.2 [Source:ZFIN;Acc:ZDB-GENE-060503-1... [more]
cacna2d1a1.098e-6628.55calcium channel, voltage-dependent, alpha 2/delta ... [more]
cacna2d1a1.398e-6628.44calcium channel, voltage-dependent, alpha 2/delta ... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CACNA2D21.603e-7829.35calcium voltage-gated channel auxiliary subunit al... [more]
cacna2d11.727e-7028.20calcium channel, voltage-dependent, alpha 2/delta ... [more]
CACNA2D25.053e-6730.06calcium voltage-gated channel auxiliary subunit al... [more]
CACNA2D22.213e-6427.32calcium voltage-gated channel auxiliary subunit al... [more]
CACNA2D36.754e-6232.72calcium channel, voltage-dependent, alpha 2/delta ... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cacna2d21.145e-7929.84calcium channel, voltage-dependent, alpha 2/delta ... [more]
Cacna2d21.280e-7929.84calcium channel, voltage-dependent, alpha 2/delta ... [more]
Cacna2d21.367e-7929.84calcium channel, voltage-dependent, alpha 2/delta ... [more]
Cacna2d21.446e-7929.84calcium channel, voltage-dependent, alpha 2/delta ... [more]
Cacna2d21.487e-7929.84calcium channel, voltage-dependent, alpha 2/delta ... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8CFG6|CA2D2_RAT2.999e-7930.17Voltage-dependent calcium channel subunit alpha-2/... [more]
sp|Q6PHS9|CA2D2_MOUSE1.011e-7829.84Voltage-dependent calcium channel subunit alpha-2/... [more]
sp|Q9NY47|CA2D2_HUMAN3.505e-7829.52Voltage-dependent calcium channel subunit alpha-2/... [more]
sp|P54289|CA2D1_HUMAN5.406e-6628.11Voltage-dependent calcium channel subunit alpha-2/... [more]
sp|Q8CFG5|CA2D3_RAT6.545e-6631.49Voltage-dependent calcium channel subunit alpha-2/... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A267DMV81.521e-16131.30VWFA domain-containing protein OS=Macrostomum lign... [more]
A0A267GU031.005e-12843.28VWFA domain-containing protein (Fragment) OS=Macro... [more]
A0A267F2P73.955e-10635.41VWFA domain-containing protein OS=Macrostomum lign... [more]
A0A267GUH74.977e-10634.72VWFA domain-containing protein OS=Macrostomum lign... [more]
A0A2R2MM073.312e-10438.87voltage-dependent calcium channel subunit alpha-2/... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cacna2d2b4.982e-7232.26calcium channel, voltage-dependent, alpha 2/delta ... [more]
si:dkey-266j7.23.560e-6830.56calcium voltage-gated channel auxiliary subunit al... [more]
CACNA2D32.784e-6632.32calcium voltage-gated channel auxiliary subunit al... [more]
CACNA2D33.238e-6632.32calcium voltage-gated channel auxiliary subunit al... [more]
CACNA2D33.512e-6632.70calcium voltage-gated channel auxiliary subunit al... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
cacna2d1a2.542e-5829.47calcium channel, voltage-dependent, alpha 2/delta ... [more]
cacna2d4b6.899e-4726.57calcium channel, voltage-dependent, alpha 2/delta ... [more]
ENSPMAT00000001351.12.281e-1922.60pep scaffold:Pmarinus_7.0:GL479089:992:16661:1 gen... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO446032.528e-2823.60Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO299392.016e-2544.95Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO386781.541e-2441.82Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO482107.879e-2325.31Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO469791.987e-1624.08Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cacna2d2a1.477e-7930.81calcium voltage-gated channel auxiliary subunit al... [more]
cacna2d2a2.035e-7931.07calcium voltage-gated channel auxiliary subunit al... [more]
cacna2d2a2.296e-7930.81calcium voltage-gated channel auxiliary subunit al... [more]
cacna2d2b1.598e-7429.31voltage-dependent calcium channel subunit alpha-2/... [more]
cacna2d1a2.820e-7329.01voltage-dependent calcium channel subunit alpha-2/... [more]
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BLAST of Voltage-dependent calcium channel subunit alpha-2/delta-2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000021966.10.000e+0100.00SMESG000021966.1[more]
SMESG000021966.10.000e+0100.00SMESG000021966.1[more]
SMESG000020648.11.487e-3623.07SMESG000020648.1[more]
SMESG000020648.12.579e-3623.07SMESG000020648.1[more]
SMESG000020648.13.973e-3623.07SMESG000020648.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30025296 ID=SMED30025296|Name=Voltage-dependent calcium channel subunit alpha-2/delta-2|organism=Schmidtea mediterranea sexual|type=transcript|length=3620bp
GCCCTTTTTAGTGATTCTATTTTTTTTCTAAATGGATTTTTCAAGATTTC
TCCTACTGATATTTCTGTCTTCCTTCATTAAGCAAATGAAAATGGATATA
TTAAGTTCTTTGGAGAACCTCCAAATGGAATTCGATAAATTTATGCGAAA
TCAATTTTCAGTATTCCAGGAACCTACAATCGCGAATATTTACAGTGAAA
TCGGTCAAAAAGGTGGAATTGAAACATTCCCAGTCAATCCATTAGAAATA
GCAAAAGACTTTTCTAACAAATTGGCCAACGAATTTCGCAAGAAAATGGA
ATCACTAAAAAGGGCAGTGGATTTCGCAGAAGAAGAAGCGACAAAATATC
AATATGATCCTCATATCAAGCCAGAAGAGGTTCAATATATCAACTCGAAA
GACCTGCCAGAAAATTCAGAATTGCTGGTCGATCATCCTCTATTCAAAAC
GAGAGTTATAGCAAATCAGTCATCCGTGCATATTCCAACAGAGATTTATA
AAGAAGATTCCTTCATATTAAATACACTAAAATGGACACAAAAATTAAAT
AACATTTTCATCAGAGCATCCAATAATTTAAGATATCAGTATTTTGCTTC
TTTCACGGGAATTGTGCTACAGTATCCAGGAATGAGATGGAGGAAAAAAG
GAACGGATATGTTTGATGTACGACGGAGACAATGGTATGTGCAAGGCGCG
TCATCTCCTAAAGACGTGATGGTTCTTATTGATACAAGCGGAAGTATGCA
TGGAATAGCAATTAAACTGACAAAATCAGCGGTGGAAAAACTAATAGATA
CGATGGGGGAAAATGATTATATTGCTGTTACCCATTTTCCTCCAGGGAAA
AACCAAGCAATGCAATTAATAAAGGACTACCCATTTATACAAACAAAGCC
TTGTTTTGCAACATTTGTGCAAGCCAGTAAACGAAATAAAGATCGCCTCT
TCAAACAAATATTCCAACTGAGAGCTCAAGGAATTGCCAATTTAGACACT
GCATTAGAATTTGCAATTAATGAATTCCATAAATTTGATAACCGCACTGA
AAAAGGAAACGAGGGGGCCAACTGCAACAGACTGATTGTGGTGTTCACTG
ATAGCGGCGATGAGTACGATAAGGAAAAAATAAGATCATTAATGAATCGC
TCGAACACCACGAAAAATTTAAGAATATTTATTTATTATGTCGGAGAGGA
AATCACGCCAATTGATGTGTTGGAAAATCGGACCTGTGAATACAGAGGTT
ACTTCGGTCATATTCACGCAATGGGAGCCGTTTCAAATATAATAGATAAG
TATTCCAAAACGGTTCACTATCACACGATCCACAGAGAAAATCAAATGGA
AGATAACGAATTTAGGATAGATTTAGTATCAGTAAATGAAGATGGATTTC
ATAATCCTGAGGATTTCCCACCTATGGGCCTTGGACTAATGACAAGTTTG
ACAATGCCCGTTTATAATAGATCGGGCAACGGATCATTTCTAGGCTTGCT
TGGAACTGACATGACAGTAGCCTTCATGGATGAATTGGTACCGCATGACA
AACTTGGAAGAAACGGATACGCATTTGCAATAAATACAAATGGCTATATC
ATTTTCCATCCAGAGCTGAAAAACCAGCTCGGCTGGATGCGTGACCCTCC
AAACGTCGATTTGACTGAAATTGAATTTGATTCAGATGAGAAAACCAAGA
TTCGTTCTAAAATTATCAATTGTGCCGCTTCCAATGGAACCGAGTACGGG
GAAGATGATGTCATAAGCCTCATAAAAGTTTCTGATGAAATTCACACATA
TGAAAAATCGAGAACGTATTCTTACACTGGGGTTCCTTATTCTACTTTTG
GAATTACAATTGTCAATTCAAAATATAATAAATATTATCCGGTGTTTTCC
CAGGACATCAAATTAATAAAACTTCTAGAATGCTCCCATGTTCACTGCTC
AATGGTTGTAAGCTTGCCTAGCGATTTGAATTCCCAGTTGCAATTCACGA
ATGACATATTCGTATATGCCGAACTCGGATTAATTGGCAAATGCAAAATC
ATAAAAGACAATTTTAGTTTTTCATCTACAACTACAACTACGACAACTCA
GCAAACAAGTTCGACACGTCAATATTCTGAGACTAAAAGGAGGAAAATTG
AAAAAACTGCTGCTCAGATAGTGCCGTTGGGCTCAATGGATTCTTCTATG
GCCAACACAATTTCAGCTATCCAGTCATTCAATATCTCCACTAATCCATC
CGTTATCCGTGACAAGGAAACCAACATTTCTAACGGCGATGAGGTCACAA
AGTTTTCAGTGGAATTAATAAAAATCCTAAACCATCTTCAAAACCATTCC
GATGACAAATGCCCTCATTACGAGAGCAGACGACTGATTACAGATTTGTA
TGTTTTGGAGAAGGTAGAGAAATTTCTGAAGAGATCAGATTCTCTTACCT
CAGTAATCATGTCAACATTGACTGGGCTGTCAATGGTCAATCCGAAAAGT
GAAAGGCACATTTACAAAGATCTCTTTGATAATTGGTTGAATTCGACAAT
GTTCCAGAGGACGTTTGACATGGAAAAGTTTATTTTCTACACCCTATTCA
ACATTCAAGATCTCCAGAAAGAACCGGATAATTCTAATAATAATTCTTTT
CCAGATTTGAAGGTATTCAAGTCTTTCTCTGTAACTATGAAACCTGATCA
CGTGATACCCATTGCAGTTCTCGGATTATCGTTAAAACAACTCCCACTTG
TCAGTATTATGCAGAAATATGAAGCGTGCAACAAGACGAGACTCTGCTAT
CTCATTGAAGATGGGGGTTATGTTATTTCGGTCAATGATAAGAAACTTTT
ACATCAGGTTGGCTCTTTCTTCGGACAAATTAGCCCTCTGGTCATGGACA
TACTCATTAATAATTCGATTTTTAAAAGTATTGAAGATTTTGATTACCAA
GCAATTTGTCCAAAGGAAAAGGATGAGGAAATTTCGTCGTCAAGTAGTAG
ACTGAAACCGCTCACAACTTTGCTATCAATCCCGGTTGTAATTTGCAAAA
AGATTTTGTTCTATTTGGAAAATATCTTTTTATTTATCAGGTTACTAATT
CAATTGGCTCTCATTCATTTTAGCTCCGCTCAAGAGGCAACTGCAACCGA
TAACAAAAACATAAGTTGCATTAAAAAATATCACCGATTCTACTTTAACG
AATCATCACTGAATTCACTCCCAACAGAAATAACGCAAACTTGCAAAAAT
TGCACATTTTCAATATACGTTACTAGAATGAACACATCCAATCTAATTAT
AGTCAGTTACGACGAAACACAATGCTCAAACAACTGTAATTACAACACAC
AGCCCAATCGATACCCAATAAAAGACCCGGGACCCGACATTTGCAAACTA
TCAAACGAACCTCGTTATCGATTACGACCGAAATACAAATGCTATGGATT
CAATCCCGATGAGAACTTTATGAAATGCAATTCTGATAAGCTAGATTATT
TTATTAGCACAACACGCCTGTTTACTTTCATTTTAGCTACAACATGCCTT
TTAATAATAAACAATTTGCATTTATAAATATTACAACGAATTAGAATGGT
TATTAATATCAATACAACGC
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protein sequence of SMED30025296-orf-1

>SMED30025296-orf-1 ID=SMED30025296-orf-1|Name=SMED30025296-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1182bp
MDFSRFLLLIFLSSFIKQMKMDILSSLENLQMEFDKFMRNQFSVFQEPTI
ANIYSEIGQKGGIETFPVNPLEIAKDFSNKLANEFRKKMESLKRAVDFAE
EEATKYQYDPHIKPEEVQYINSKDLPENSELLVDHPLFKTRVIANQSSVH
IPTEIYKEDSFILNTLKWTQKLNNIFIRASNNLRYQYFASFTGIVLQYPG
MRWRKKGTDMFDVRRRQWYVQGASSPKDVMVLIDTSGSMHGIAIKLTKSA
VEKLIDTMGENDYIAVTHFPPGKNQAMQLIKDYPFIQTKPCFATFVQASK
RNKDRLFKQIFQLRAQGIANLDTALEFAINEFHKFDNRTEKGNEGANCNR
LIVVFTDSGDEYDKEKIRSLMNRSNTTKNLRIFIYYVGEEITPIDVLENR
TCEYRGYFGHIHAMGAVSNIIDKYSKTVHYHTIHRENQMEDNEFRIDLVS
VNEDGFHNPEDFPPMGLGLMTSLTMPVYNRSGNGSFLGLLGTDMTVAFMD
ELVPHDKLGRNGYAFAINTNGYIIFHPELKNQLGWMRDPPNVDLTEIEFD
SDEKTKIRSKIINCAASNGTEYGEDDVISLIKVSDEIHTYEKSRTYSYTG
VPYSTFGITIVNSKYNKYYPVFSQDIKLIKLLECSHVHCSMVVSLPSDLN
SQLQFTNDIFVYAELGLIGKCKIIKDNFSFSSTTTTTTTQQTSSTRQYSE
TKRRKIEKTAAQIVPLGSMDSSMANTISAIQSFNISTNPSVIRDKETNIS
NGDEVTKFSVELIKILNHLQNHSDDKCPHYESRRLITDLYVLEKVEKFLK
RSDSLTSVIMSTLTGLSMVNPKSERHIYKDLFDNWLNSTMFQRTFDMEKF
IFYTLFNIQDLQKEPDNSNNNSFPDLKVFKSFSVTMKPDHVIPIAVLGLS
LKQLPLVSIMQKYEACNKTRLCYLIEDGGYVISVNDKKLLHQVGSFFGQI
SPLVMDILINNSIFKSIEDFDYQAICPKEKDEEISSSSSRLKPLTTLLSI
PVVICKKILFYLENIFLFIRLLIQLALIHFSSAQEATATDNKNISCIKKY
HRFYFNESSLNSLPTEITQTCKNCTFSIYVTRMNTSNLIIVSYDETQCSN
NCNYNTQPNRYPIKDPGPDICKLSNEPRYRLRPKYKCYGFNPDENFMKCN
SDKLDYFISTTRLFTFILATTCLLIINNLHL*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR036465vWFA_dom_sf
IPR002035VWF_A
IPR013608VWA_N
IPR013680VDCC_a2/dsu
Vocabulary: molecular function
TermDefinition
GO:0005246calcium channel regulator activity
GO:0005262calcium channel activity
GO:0046872metal ion binding
GO:0005244voltage-gated ion channel activity
GO:0005245voltage-gated calcium channel activity
Vocabulary: cellular component
TermDefinition
GO:0005891voltage-gated calcium channel complex
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: biological process
TermDefinition
GO:0006810transport
GO:0006811ion transport
GO:0006816calcium ion transport
GO:0065009regulation of molecular function
GO:0070588calcium ion transmembrane transport
GO:0034765regulation of ion transmembrane transport
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 82..109
NoneNo IPR availableGENE3DG3DSA:3.30.450.20coord: 470..614
e-value: 3.1E-13
score: 51.7
NoneNo IPR availablePANTHERPTHR10166:SF7VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-2coord: 914..1150
NoneNo IPR availablePANTHERPTHR10166VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATEDcoord: 914..1150
coord: 57..619
NoneNo IPR availablePANTHERPTHR10166:SF7VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-2coord: 57..619
NoneNo IPR availableCDDcd12912PDC2_MCP_likecoord: 498..563
e-value: 0.00148342
score: 36.977
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..18
score: 0.523
IPR002035von Willebrand factor, type ASMARTSM00327VWA_4coord: 226..419
e-value: 2.2E-9
score: 47.2
IPR002035von Willebrand factor, type APFAMPF00092VWAcoord: 228..388
e-value: 6.7E-11
score: 42.7
IPR002035von Willebrand factor, type APROSITEPS50234VWFAcoord: 228..428
score: 16.135
IPR013608VWA N-terminalPFAMPF08399VWA_Ncoord: 99..203
e-value: 9.0E-19
score: 68.2
IPR036465von Willebrand factor A-like domain superfamilyGENE3DG3DSA:3.40.50.410coord: 227..427
e-value: 6.7E-18
score: 67.3
IPR036465von Willebrand factor A-like domain superfamilySUPERFAMILYSSF53300vWA-likecoord: 226..421
IPR013680Voltage-dependent calcium channel, alpha-2/delta subunit, conserved regionPFAMPF08473VGCC_alpha2coord: 749..1149
e-value: 9.3E-38
score: 130.1