H/ACA ribonucleoprotein complex subunit 4

Overview
NameH/ACA ribonucleoprotein complex subunit 4
Smed IDSMED30025222
Length (bp)1469
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of H/ACA ribonucleoprotein complex subunit 4 (SMED30025222) t-SNE clustered cells

Violin plots show distribution of expression levels for H/ACA ribonucleoprotein complex subunit 4 (SMED30025222) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of H/ACA ribonucleoprotein complex subunit 4 (SMED30025222) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for H/ACA ribonucleoprotein complex subunit 4 (SMED30025222) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30025222

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30025222SMESG000029771.1 SmedASXL_009959SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30025222SMESG000029771.1 SmedASXL_009959SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
epidermisSMED30025222SMESG000029771.1 dd_Smed_v4_4087_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30025222SMESG000029771.1 dd_Smed_v4_4087_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30025222SMESG000029771.1 dd_Smed_v4_4087_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30025222SMESG000029771.1 dd_Smed_v4_4087_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Human
Match: DKC1 (dyskerin pseudouridine synthase 1 [Source:HGNC Symbol;Acc:HGNC:2890])

HSP 1 Score: 452.595 bits (1163), Expect = 1.883e-156
Identity = 228/356 (64.04%), Postives = 282/356 (79.21%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRL 1206
            F ++   +   +D S WPLLLKNF K+NVR  H+TP   G +PL+R I +Y+++G INLDKPSNPSSHEVVAW++R L V+KTGHSGTLDPKVTGCLIVC++RATRLVKSQQ+AGKEYV I ++        ++ +ALE + GAL Q PPLI AVKR LR+RT+Y+ K+IEYD +R LG+ WV CEAGTYIRTLCVH+G  LGV   M ELRRVRSG+M+E D+MVT+HDVLDA  +Y  H DESYLRRVV PLE LL  HKR+++KDSAV A+ +GAK+MLPGVLRY++ I VN EIV++TTKGEA+ +AIALMTTA + +CDHG VAK+KRVIMERD Y R+WG G  A+ K+L
Sbjct:   36 FLIKPESKVAKLDTSQWPLLLKNFDKLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKL 391
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Human
Match: DKC1 (dyskerin pseudouridine synthase 1 [Source:HGNC Symbol;Acc:HGNC:2890])

HSP 1 Score: 455.292 bits (1170), Expect = 3.513e-156
Identity = 228/356 (64.04%), Postives = 282/356 (79.21%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRL 1206
            F ++   +   +D S WPLLLKNF K+NVR  H+TP   G +PL+R I +Y+++G INLDKPSNPSSHEVVAW++R L V+KTGHSGTLDPKVTGCLIVC++RATRLVKSQQ+AGKEYV I ++        ++ +ALE + GAL Q PPLI AVKR LR+RT+Y+ K+IEYD +R LG+ WV CEAGTYIRTLCVH+G  LGV   M ELRRVRSG+M+E D+MVT+HDVLDA  +Y  H DESYLRRVV PLE LL  HKR+++KDSAV A+ +GAK+MLPGVLRY++ I VN EIV++TTKGEA+ +AIALMTTA + +CDHG VAK+KRVIMERD Y R+WG G  A+ K+L
Sbjct:   36 FLIKPESKVAKLDTSQWPLLLKNFDKLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKL 391
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Human
Match: DKC1 (dyskerin pseudouridine synthase 1 [Source:HGNC Symbol;Acc:HGNC:2890])

HSP 1 Score: 276.944 bits (707), Expect = 4.966e-90
Identity = 139/263 (52.85%), Postives = 172/263 (65.40%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKR 927
            F ++   +   +D S WPLLLKNF K+NVR  H+TP   G +PL+R I +Y+++G INLDKPSNPSSHEVVAW++R L V+KTGHSGTLDPKVTGCLIVC++RATRLVKSQQ+AGKEYV I ++        ++ +ALE + GAL Q PPLI AVKR LR+RT+Y+ K+IEYD +R LG+ W                                        D+MVT+HDVLDA  +Y  H DESYLRRVV PLE LL  HKR
Sbjct:   36 FLIKPESKVAKLDTSQWPLLLKNFDKLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFW----------------------------------------DHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKR 258
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Human
Match: DKC1 (dyskerin pseudouridine synthase 1 [Source:HGNC Symbol;Acc:HGNC:2890])

HSP 1 Score: 259.61 bits (662), Expect = 8.963e-84
Identity = 124/208 (59.62%), Postives = 154/208 (74.04%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRG-----------LGVLWVKCEAGTYIRTLCVH 729
            F ++   +   +D S WPLLLKNF K+NVR  H+TP   G +PL+R I +Y+++G INLDKPSNPSSHEVVAW++R L V+KTGHSGTLDPKVTGCLIVC++RATRLVKSQQ+AGKEYV I ++        ++ +ALE + GAL Q PPLI AVKR LR+RT+Y+ K+IEYD +R            LG+ WV CEAGTYIRTLCVH
Sbjct:   22 FLIKPESKVAKLDTSQWPLLLKNFDKLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGAAFLLCVCILGIFWVSCEAGTYIRTLCVH 229
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Human
Match: DKC1 (dyskerin pseudouridine synthase 1 [Source:HGNC Symbol;Acc:HGNC:2890])

HSP 1 Score: 222.631 bits (566), Expect = 9.123e-70
Identity = 119/177 (67.23%), Postives = 144/177 (81.36%), Query Frame = 1 
Query:  676 VLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRL 1206
            + WV CEAGTYIRTLCVH+G  LGV   M ELRRVRSG+M+E D+MVT+HDVLDA  +Y  H DESYLRRVV PLE LL  HKR+++KDSAV A+ +GAK+MLPGVLRY++ I VN EIV++TTKGEA+ +AIALMTTA + +CDHG VAK+KRVIMERD Y R+WG G  A+ K+L
Sbjct:    2 IFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKL 178
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Celegans
Match: K01G5.5 (Putative H/ACA ribonucleoprotein complex subunit 4 [Source:UniProtKB/Swiss-Prot;Acc:O17919])

HSP 1 Score: 441.81 bits (1135), Expect = 2.270e-152
Identity = 216/356 (60.67%), Postives = 271/356 (76.12%), Query Frame = 1 
Query:  136 TFAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKR 1203
            +F + S++    +D S WPLLLKN+ K+NVR  H+TP  +G SPL+R I  Y+ SG  NLDKPSNPSSHEVV+W+KR L  +KTGHSGTLDPKV+GCLIVC+DR TRL KSQQ AGKEY+ IFK+ +   D +KV QALEK+ GAL Q PPLI AVKR LRIRTVY+ K IEYD  + +G+    CE+GTY+RT+CVH+G  LG    M ELRR RSGI  EN+NMVT+HDVLDA ++     DESY+R +V PLE LL +HKRV++KDS + A+ +GAK+++PG+LRYD+DI V  EIVIM+TKGEA+ +AIA M T+T+ S DHG VAK KRVIMERD+Y R+WG G  A+ K+
Sbjct:   23 SFQLPSSNETAKLDASQWPLLLKNYDKLNVRTNHYTPHVEGVSPLKRDIKNYISSGFFNLDKPSNPSSHEVVSWIKRILRCEKTGHSGTLDPKVSGCLIVCIDRTTRLAKSQQGAGKEYICIFKLHEEVEDDRKVKQALEKLTGALFQRPPLISAVKRQLRIRTVYENKFIEYDPAQQMGIFNCICESGTYVRTICVHLGLILGCGGQMQELRRNRSGICDENENMVTMHDVLDAQYLLDTQKDESYMRHIVRPLEALLTQHKRVVVKDSCINAICYGAKILIPGILRYDDDIEVGKEIVIMSTKGEAICIAIAQMNTSTIASVDHGVVAKSKRVIMERDVYGRKWGLGPVASKKK 378
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Fly
Match: Nop60B (gene:FBgn0259937 transcript:FBtr0072258)

HSP 1 Score: 475.322 bits (1222), Expect = 2.041e-164
Identity = 238/355 (67.04%), Postives = 283/355 (79.72%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKR 1203
            F ++ + +   +D S WPLLLKNF K+N+R  H+TP   G SPL R I EY+K+G INLDKPSNPSSHEVVAW+K+ L V+KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ+AGKEYVAIFK+      V KV Q LEK++GAL Q PPLI AVKR LR+RTVYD KL++YDE R +GV WV CEAG+YIRT+CVH+G  LGV   M ELRRVRSGI +E D MVT+HDVLDA  +Y+ H DES LRRV+ PLE LLV HKR+++KDS+V AV +GAK+ LPGVLRY++ I ++ EIVI TTKGEA+ LAIALMTTATM SCDHG VAK+KRVIMERD Y R+WG G  A+ K+
Sbjct:   34 FQIKPSSKIAELDTSQWPLLLKNFDKLNIRSNHYTPLAHGSSPLNRDIKEYMKTGFINLDKPSNPSSHEVVAWIKKILKVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVAIFKLHGAVESVAKVRQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDETRNMGVFWVSCEAGSYIRTMCVHLGLVLGVGGQMLELRRVRSGIQSERDGMVTMHDVLDAMWLYENHKDESMLRRVIKPLEGLLVNHKRIIMKDSSVNAVCYGAKITLPGVLRYEDGIEIDQEIVICTTKGEAICLAIALMTTATMASCDHGVVAKIKRVIMERDTYPRKWGLGPKASAKK 388
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Fly
Match: Nop60B (gene:FBgn0259937 transcript:FBtr0300861)

HSP 1 Score: 475.322 bits (1222), Expect = 2.041e-164
Identity = 238/355 (67.04%), Postives = 283/355 (79.72%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKR 1203
            F ++ + +   +D S WPLLLKNF K+N+R  H+TP   G SPL R I EY+K+G INLDKPSNPSSHEVVAW+K+ L V+KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ+AGKEYVAIFK+      V KV Q LEK++GAL Q PPLI AVKR LR+RTVYD KL++YDE R +GV WV CEAG+YIRT+CVH+G  LGV   M ELRRVRSGI +E D MVT+HDVLDA  +Y+ H DES LRRV+ PLE LLV HKR+++KDS+V AV +GAK+ LPGVLRY++ I ++ EIVI TTKGEA+ LAIALMTTATM SCDHG VAK+KRVIMERD Y R+WG G  A+ K+
Sbjct:   34 FQIKPSSKIAELDTSQWPLLLKNFDKLNIRSNHYTPLAHGSSPLNRDIKEYMKTGFINLDKPSNPSSHEVVAWIKKILKVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVAIFKLHGAVESVAKVRQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDETRNMGVFWVSCEAGSYIRTMCVHLGLVLGVGGQMLELRRVRSGIQSERDGMVTMHDVLDAMWLYENHKDESMLRRVIKPLEGLLVNHKRIIMKDSSVNAVCYGAKITLPGVLRYEDGIEIDQEIVICTTKGEAICLAIALMTTATMASCDHGVVAKIKRVIMERDTYPRKWGLGPKASAKK 388
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Fly
Match: Nop60B (gene:FBgn0259937 transcript:FBtr0300227)

HSP 1 Score: 475.322 bits (1222), Expect = 2.041e-164
Identity = 238/355 (67.04%), Postives = 283/355 (79.72%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKR 1203
            F ++ + +   +D S WPLLLKNF K+N+R  H+TP   G SPL R I EY+K+G INLDKPSNPSSHEVVAW+K+ L V+KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ+AGKEYVAIFK+      V KV Q LEK++GAL Q PPLI AVKR LR+RTVYD KL++YDE R +GV WV CEAG+YIRT+CVH+G  LGV   M ELRRVRSGI +E D MVT+HDVLDA  +Y+ H DES LRRV+ PLE LLV HKR+++KDS+V AV +GAK+ LPGVLRY++ I ++ EIVI TTKGEA+ LAIALMTTATM SCDHG VAK+KRVIMERD Y R+WG G  A+ K+
Sbjct:   34 FQIKPSSKIAELDTSQWPLLLKNFDKLNIRSNHYTPLAHGSSPLNRDIKEYMKTGFINLDKPSNPSSHEVVAWIKKILKVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVAIFKLHGAVESVAKVRQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDETRNMGVFWVSCEAGSYIRTMCVHLGLVLGVGGQMLELRRVRSGIQSERDGMVTMHDVLDAMWLYENHKDESMLRRVIKPLEGLLVNHKRIIMKDSSVNAVCYGAKITLPGVLRYEDGIEIDQEIVICTTKGEAICLAIALMTTATMASCDHGVVAKIKRVIMERDTYPRKWGLGPKASAKK 388
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Fly
Match: Nop60B (gene:FBgn0259937 transcript:FBtr0100213)

HSP 1 Score: 475.322 bits (1222), Expect = 2.041e-164
Identity = 238/355 (67.04%), Postives = 283/355 (79.72%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKR 1203
            F ++ + +   +D S WPLLLKNF K+N+R  H+TP   G SPL R I EY+K+G INLDKPSNPSSHEVVAW+K+ L V+KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ+AGKEYVAIFK+      V KV Q LEK++GAL Q PPLI AVKR LR+RTVYD KL++YDE R +GV WV CEAG+YIRT+CVH+G  LGV   M ELRRVRSGI +E D MVT+HDVLDA  +Y+ H DES LRRV+ PLE LLV HKR+++KDS+V AV +GAK+ LPGVLRY++ I ++ EIVI TTKGEA+ LAIALMTTATM SCDHG VAK+KRVIMERD Y R+WG G  A+ K+
Sbjct:   34 FQIKPSSKIAELDTSQWPLLLKNFDKLNIRSNHYTPLAHGSSPLNRDIKEYMKTGFINLDKPSNPSSHEVVAWIKKILKVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVAIFKLHGAVESVAKVRQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDETRNMGVFWVSCEAGSYIRTMCVHLGLVLGVGGQMLELRRVRSGIQSERDGMVTMHDVLDAMWLYENHKDESMLRRVIKPLEGLLVNHKRIIMKDSSVNAVCYGAKITLPGVLRYEDGIEIDQEIVICTTKGEAICLAIALMTTATMASCDHGVVAKIKRVIMERDTYPRKWGLGPKASAKK 388
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Fly
Match: Nop60B (gene:FBgn0259937 transcript:FBtr0304599)

HSP 1 Score: 254.218 bits (648), Expect = 5.370e-82
Identity = 122/189 (64.55%), Postives = 145/189 (76.72%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGT 705
            F ++ + +   +D S WPLLLKNF K+N+R  H+TP   G SPL R I EY+K+G INLDKPSNPSSHEVVAW+K+ L V+KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ+AGKEYVAIFK+      V KV Q LEK++GAL Q PPLI AVKR LR+RTVYD KL++YDE R + +L   C   T
Sbjct:   34 FQIKPSSKIAELDTSQWPLLLKNFDKLNIRSNHYTPLAHGSSPLNRDIKEYMKTGFINLDKPSNPSSHEVVAWIKKILKVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVAIFKLHGAVESVAKVRQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDETRNMDLLIRLCNIWT 222
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Zebrafish
Match: dkc1 (dyskeratosis congenita 1, dyskerin [Source:ZFIN;Acc:ZDB-GENE-031118-120])

HSP 1 Score: 446.047 bits (1146), Expect = 8.366e-153
Identity = 223/368 (60.60%), Postives = 286/368 (77.72%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRLNSVKSEMNESNK 1242
            F ++   +   +D S WPLLLKNF K+N+R  H+TP   G +PL+R I +Y++SG INLDKP+NPSSHEVVAW+KR L V+KTGHSGTLDPKVTGCLIVC++RATRLVKSQQ+AGKEYV I ++     +  ++ +ALE + GAL Q PPLI AVKR LR+RT+Y+ KLIEYD +R LG+ WV CEAGTYIRTLCVH+G  LGV   M ELRRVRSG++ E DN+VT+HDVLDA   +  + DE+YLRRV+ PLE LL+ HKR+++KDSAV A+ +GAK+MLPGVLRY++ I VN +IV++TTKGEA+  A+ALMTTA + +CDHG VAK+KRVIMERD Y R+WG G  A+ K++   K  +++  K
Sbjct:   31 FLIKPESKVASLDTSQWPLLLKNFDKLNIRTAHYTPLPHGSNPLKRGIHDYVRSGFINLDKPANPSSHEVVAWIKRILRVEKTGHSGTLDPKVTGCLIVCVERATRLVKSQQSAGKEYVGIVRLHNALENEHQLARALECLTGALFQRPPLIAAVKRQLRVRTIYESKLIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVLGEKDNLVTMHDVLDAQWQFDHNKDETYLRRVIFPLEKLLISHKRIVMKDSAVNAICYGAKIMLPGVLRYEDGIEVNQDIVVITTKGEAICTAVALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKKMMIQKGLLDKHGK 398
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Zebrafish
Match: trub1 (TruB pseudouridine (psi) synthase family member 1 [Source:ZFIN;Acc:ZDB-GENE-080723-73])

HSP 1 Score: 65.855 bits (159), Expect = 1.649e-11
Identity = 63/252 (25.00%), Postives = 108/252 (42.86%), Query Frame = 1 
Query:  256 GFSPLQRPIDEYLKS--GVINLDKPSNPSSHEVVAWVKRAL----GVD-----------KTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKP--GIDV---------------KKVHQALEKVKGALLQLPPLICAVKRT------------------LRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMV-----TLHDVLDA 840
            G S +Q      L+S  G+  + K   P+S +V+  +K+ L    GV            K GH GTLD   +G L+V +   T+++ +     K+Y A  ++ K    +DV               +   + +++  G ++Q+PPL  A+K+                    R  TVY+L L ++     L  + V+C  G Y+R+L   +G  L   A++ EL R + G  T  ++ +     TL D+  A
Sbjct:    3 GASTVQNSSLSKLQSLHGIFAIHKKKGPTSADVLNILKKTLLKEAGVTNFNPRKRKQPFKIGHGGTLDSNASGVLVVGIGEGTKMLTTMLAGSKKYTAFGELGKATDTLDVTGNVVEEKSYDHITKEAFEEKMKQFTGEIMQVPPLYSALKKDGKRMSVLLKQGQEVEAKPARPVTVYNLSLEDFSPP--LFTIDVECGGGFYVRSLIDDLGKALSSCAHIKELTRTKQGQFTLEEHALKEDRWTLTDISQA 252
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Xenopus
Match: wbp2nl (WBP2 N-terminal like [Source:Xenbase;Acc:XB-GENE-951203])

HSP 1 Score: 461.07 bits (1185), Expect = 1.217e-159
Identity = 225/368 (61.14%), Postives = 286/368 (77.72%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRLNSVKSEMNESNK 1242
            F ++   +   +D S WPLLLKNF K+N+R  H+TP   G +PL+R I EY+K+G INLDKP+NPSSHEVVAW++R L  +KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ+AGKEYV I ++     +  ++ +ALE + GAL Q PPLI AVKR LR+RT+Y+ KLIEYD +R LG+ WV CEAGTYIRTLCVHIG  LGV   M ELRRVRSG++ E DN+VT+HDVLDA   +  + DESYLRRV+ PLE LLV HKR+++KDSAV A+ +GAK+MLPG+LRY++ I +N EIV++TTKGEA+ +A+ALMTTA + +CDHG VAK+KRVIMERD Y R+WG G  A+ K++   K  +++  K
Sbjct:   20 FLIKPESKVAQLDTSQWPLLLKNFDKLNIRTAHYTPIPSGSNPLKREISEYIKTGFINLDKPANPSSHEVVAWIRRILRSEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVGIVRLHNALENELQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKLIEYDPERRLGIFWVSCEAGTYIRTLCVHIGLLLGVGGQMQELRRVRSGVLGEKDNLVTMHDVLDAQWQFDNNKDESYLRRVIFPLEKLLVSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIELNQEIVVITTKGEAICIAVALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKKMMIQKGLLDKHGK 387
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Xenopus
Match: wbp2nl (WBP2 N-terminal like [Source:Xenbase;Acc:XB-GENE-951203])

HSP 1 Score: 459.914 bits (1182), Expect = 6.342e-159
Identity = 225/368 (61.14%), Postives = 286/368 (77.72%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRLNSVKSEMNESNK 1242
            F ++   +   +D S WPLLLKNF K+N+R  H+TP   G +PL+R I EY+K+G INLDKP+NPSSHEVVAW++R L  +KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ+AGKEYV I ++     +  ++ +ALE + GAL Q PPLI AVKR LR+RT+Y+ KLIEYD +R LG+ WV CEAGTYIRTLCVHIG  LGV   M ELRRVRSG++ E DN+VT+HDVLDA   +  + DESYLRRV+ PLE LLV HKR+++KDSAV A+ +GAK+MLPG+LRY++ I +N EIV++TTKGEA+ +A+ALMTTA + +CDHG VAK+KRVIMERD Y R+WG G  A+ K++   K  +++  K
Sbjct:   27 FLIKPESKVAQLDTSQWPLLLKNFDKLNIRTAHYTPIPSGSNPLKREISEYIKTGFINLDKPANPSSHEVVAWIRRILRSEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVGIVRLHNALENELQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKLIEYDPERRLGIFWVSCEAGTYIRTLCVHIGLLLGVGGQMQELRRVRSGVLGEKDNLVTMHDVLDAQWQFDNNKDESYLRRVIFPLEKLLVSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIELNQEIVVITTKGEAICIAVALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKKMMIQKGLLDKHGK 394
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Xenopus
Match: wbp2nl (WBP2 N-terminal like [Source:Xenbase;Acc:XB-GENE-951203])

HSP 1 Score: 462.996 bits (1190), Expect = 1.266e-158
Identity = 223/356 (62.64%), Postives = 281/356 (78.93%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRL 1206
            F ++   +   +D S WPLLLKNF K+N+R  H+TP   G +PL+R I EY+K+G INLDKP+NPSSHEVVAW++R L  +KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ+AGKEYV I ++     +  ++ +ALE + GAL Q PPLI AVKR LR+RT+Y+ KLIEYD +R LG+ WV CEAGTYIRTLCVHIG  LGV   M ELRRVRSG++ E DN+VT+HDVLDA   +  + DESYLRRV+ PLE LLV HKR+++KDSAV A+ +GAK+MLPG+LRY++ I +N EIV++TTKGEA+ +A+ALMTTA + +CDHG VAK+KRVIMERD Y R+WG G  A+ K++
Sbjct:   33 FLIKPESKVAQLDTSQWPLLLKNFDKLNIRTAHYTPIPSGSNPLKREISEYIKTGFINLDKPANPSSHEVVAWIRRILRSEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVGIVRLHNALENELQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKLIEYDPERRLGIFWVSCEAGTYIRTLCVHIGLLLGVGGQMQELRRVRSGVLGEKDNLVTMHDVLDAQWQFDNNKDESYLRRVIFPLEKLLVSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIELNQEIVVITTKGEAICIAVALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKKM 388
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Xenopus
Match: wbp2nl (WBP2 N-terminal like [Source:Xenbase;Acc:XB-GENE-951203])

HSP 1 Score: 459.144 bits (1180), Expect = 2.478e-158
Identity = 225/368 (61.14%), Postives = 286/368 (77.72%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRLNSVKSEMNESNK 1242
            F ++   +   +D S WPLLLKNF K+N+R  H+TP   G +PL+R I EY+K+G INLDKP+NPSSHEVVAW++R L  +KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ+AGKEYV I ++     +  ++ +ALE + GAL Q PPLI AVKR LR+RT+Y+ KLIEYD +R LG+ WV CEAGTYIRTLCVHIG  LGV   M ELRRVRSG++ E DN+VT+HDVLDA   +  + DESYLRRV+ PLE LLV HKR+++KDSAV A+ +GAK+MLPG+LRY++ I +N EIV++TTKGEA+ +A+ALMTTA + +CDHG VAK+KRVIMERD Y R+WG G  A+ K++   K  +++  K
Sbjct:   71 FLIKPESKVAQLDTSQWPLLLKNFDKLNIRTAHYTPIPSGSNPLKREISEYIKTGFINLDKPANPSSHEVVAWIRRILRSEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVGIVRLHNALENELQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKLIEYDPERRLGIFWVSCEAGTYIRTLCVHIGLLLGVGGQMQELRRVRSGVLGEKDNLVTMHDVLDAQWQFDNNKDESYLRRVIFPLEKLLVSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIELNQEIVVITTKGEAICIAVALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKKMMIQKGLLDKHGK 438
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Xenopus
Match: wbp2nl (WBP2 N-terminal like [Source:Xenbase;Acc:XB-GENE-951203])

HSP 1 Score: 458.373 bits (1178), Expect = 3.100e-158
Identity = 225/368 (61.14%), Postives = 286/368 (77.72%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRLNSVKSEMNESNK 1242
            F ++   +   +D S WPLLLKNF K+N+R  H+TP   G +PL+R I EY+K+G INLDKP+NPSSHEVVAW++R L  +KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ+AGKEYV I ++     +  ++ +ALE + GAL Q PPLI AVKR LR+RT+Y+ KLIEYD +R LG+ WV CEAGTYIRTLCVHIG  LGV   M ELRRVRSG++ E DN+VT+HDVLDA   +  + DESYLRRV+ PLE LLV HKR+++KDSAV A+ +GAK+MLPG+LRY++ I +N EIV++TTKGEA+ +A+ALMTTA + +CDHG VAK+KRVIMERD Y R+WG G  A+ K++   K  +++  K
Sbjct:    4 FLIKPESKVAQLDTSQWPLLLKNFDKLNIRTAHYTPIPSGSNPLKREISEYIKTGFINLDKPANPSSHEVVAWIRRILRSEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVGIVRLHNALENELQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKLIEYDPERRLGIFWVSCEAGTYIRTLCVHIGLLLGVGGQMQELRRVRSGVLGEKDNLVTMHDVLDAQWQFDNNKDESYLRRVIFPLEKLLVSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIELNQEIVVITTKGEAICIAVALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKKMMIQKGLLDKHGK 371
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Mouse
Match: Dkc1 (dyskeratosis congenita 1, dyskerin [Source:MGI Symbol;Acc:MGI:1861727])

HSP 1 Score: 451.825 bits (1161), Expect = 4.295e-155
Identity = 226/356 (63.48%), Postives = 282/356 (79.21%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRL 1206
            F ++   +   +D S WPLLLKNF K+NVR  H+TP   G +PL+R I +Y+++G INLDKPSNPSSHEVVAW++R L V+KTGHSGTLDPKVTGCLIVC++RATRLVKSQQ+AGKEYV I ++        ++ +ALE + GAL Q PPLI AVKR LR+RT+Y+ K+IEYD +R LG+ WV CEAGTYIRTLCVH+G  LGV   M ELRRVRSG+M+E D+MVT+HDVLDA  +Y  H DESYLRRVV PLE LL  HKR+++KDSAV A+ +GAK+MLPG+LRY++ I VN EIV++TTKGEA+ +AIALMTTA + +CDHG VAK+KRVIMERD Y R+WG G  A+ K++
Sbjct:   36 FLIKPESKVAQLDTSQWPLLLKNFDKLNVRTAHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKM 391
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Mouse
Match: Dkc1 (dyskeratosis congenita 1, dyskerin [Source:MGI Symbol;Acc:MGI:1861727])

HSP 1 Score: 276.944 bits (707), Expect = 3.065e-90
Identity = 139/265 (52.45%), Postives = 174/265 (65.66%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVM 933
            F ++   +   +D S WPLLLKNF K+NVR  H+TP   G +PL+R I +Y+++G INLDKPSNPSSHEVVAW++R L V+KTGHSGTLDPKVTGCLIVC++RATRLVKSQQ+AGKEYV I ++        ++ +ALE + GAL Q PPLI AVKR LR+RT+Y+ K+IEYD +R LG+ W                                        D+MVT+HDVLDA  +Y  H DESYLRRVV PLE LL  HKR++
Sbjct:   36 FLIKPESKVAQLDTSQWPLLLKNFDKLNVRTAHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFW----------------------------------------DHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLV 260
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Mouse
Match: Dkc1 (dyskeratosis congenita 1, dyskerin [Source:MGI Symbol;Acc:MGI:1861727])

HSP 1 Score: 167.162 bits (422), Expect = 7.412e-49
Identity = 76/115 (66.09%), Postives = 94/115 (81.74%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAG 483
            F ++   +   +D S WPLLLKNF K+NVR  H+TP   G +PL+R I +Y+++G INLDKPSNPSSHEVVAW++R L V+KTGHSGTLDPKVTGCLIVC++RATRLVKSQQ+AG
Sbjct:   35 FLIKPESKVAQLDTSQWPLLLKNFDKLNVRTAHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAG 149
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Mouse
Match: Dkc1 (dyskeratosis congenita 1, dyskerin [Source:MGI Symbol;Acc:MGI:1861727])

HSP 1 Score: 128.642 bits (322), Expect = 5.544e-35
Identity = 58/94 (61.70%), Postives = 73/94 (77.66%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVT 420
            F ++   +   +D S WPLLLKNF K+NVR  H+TP   G +PL+R I +Y+++G INLDKPSNPSSHEVVAW++R L V+KTGHSGTLDPKVT
Sbjct:   52 FLIKPESKVAQLDTSQWPLLLKNFDKLNVRTAHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVT 145
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Mouse
Match: Trub1 (TruB pseudouridine (psi) synthase family member 1 [Source:MGI Symbol;Acc:MGI:1919383])

HSP 1 Score: 75.485 bits (184), Expect = 1.796e-14
Identity = 60/218 (27.52%), Postives = 89/218 (40.83%), Query Frame = 1 
Query:  298 SGVINLDKPSNPSSHEVV----------------AWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPG-----------------IDVKKVHQALEKVKGALLQLPPLICAVK------------------RTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMT 798
            SGV  + KP  P+S E++                 W KR     K GH GTLD    G L+V + R T+++ S  +  K Y+ I ++ K                   I  + +   L+K  G ++Q+PPL  A+K                  R  R  TV+ + L+++        L V+C  G YIR+L   IG  L   A + EL R + G  T
Sbjct:   57 SGVFAVHKPKGPTSAELLNRLKEKLLAEAGMPSPEWNKRQKQTLKVGHGGTLDSAAQGVLVVGIGRGTKMLTSMLSGSKRYITIGELGKATDTLDSTGKVTEEKPYDKITREDIEGILQKFTGNIMQVPPLYSALKKDGQRLSTLMKKGKVVEARPARPVTVHSISLLKFQPP--FFTLDVECGGGFYIRSLVSDIGKELSSCASVLELTRTKQGPFT 272
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. UniProt/SwissProt
Match: sp|O44081|DKC1_DROME (H/ACA ribonucleoprotein complex subunit 4 OS=Drosophila melanogaster OX=7227 GN=Nop60B PE=1 SV=1)

HSP 1 Score: 475.322 bits (1222), Expect = 2.046e-163
Identity = 238/355 (67.04%), Postives = 283/355 (79.72%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKR 1203
            F ++ + +   +D S WPLLLKNF K+N+R  H+TP   G SPL R I EY+K+G INLDKPSNPSSHEVVAW+K+ L V+KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ+AGKEYVAIFK+      V KV Q LEK++GAL Q PPLI AVKR LR+RTVYD KL++YDE R +GV WV CEAG+YIRT+CVH+G  LGV   M ELRRVRSGI +E D MVT+HDVLDA  +Y+ H DES LRRV+ PLE LLV HKR+++KDS+V AV +GAK+ LPGVLRY++ I ++ EIVI TTKGEA+ LAIALMTTATM SCDHG VAK+KRVIMERD Y R+WG G  A+ K+
Sbjct:   34 FQIKPSSKIAELDTSQWPLLLKNFDKLNIRSNHYTPLAHGSSPLNRDIKEYMKTGFINLDKPSNPSSHEVVAWIKKILKVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVAIFKLHGAVESVAKVRQGLEKLRGALFQRPPLISAVKRQLRVRTVYDSKLLDYDETRNMGVFWVSCEAGSYIRTMCVHLGLVLGVGGQMLELRRVRSGIQSERDGMVTMHDVLDAMWLYENHKDESMLRRVIKPLEGLLVNHKRIIMKDSSVNAVCYGAKITLPGVLRYEDGIEIDQEIVICTTKGEAICLAIALMTTATMASCDHGVVAKIKRVIMERDTYPRKWGLGPKASAKK 388
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. UniProt/SwissProt
Match: sp|O43101|CBF5_CANAL (H/ACA ribonucleoprotein complex subunit CBF5 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=CBF5 PE=3 SV=1)

HSP 1 Score: 457.603 bits (1176), Expect = 6.508e-157
Identity = 226/369 (61.25%), Postives = 284/369 (76.96%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRLNSVKSEMNESNKI 1245
            + ++    +P  D S WPLLLKN+ K+ VR  H+TP   G +PL R I  Y+ SGVINLDKPSNPSSHEVVAW+KR L V+KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ AGKEYV I ++ +   D K++++ALE + GAL Q PPLI AVKR LR+RTVYD KLIE+D KRGLGV W  CEAGTY+RTLCVH+G  LGV  +M ELRRVRSG M+E+DN+VTLHDVLDA ++Y    DESYLR+++ PLE LLV +KRV++KDSAV +V +GAK+M+PG+LRY+  I + DE+V+MTTKGEA+A+ IA M+T  + SCDHG VAK+KR IMERD Y R+WG G  A  K+      ++++  ++
Sbjct:    7 YIIKPESVSPSNDTSQWPLLLKNYDKLLVRSGHYTPIPAGSAPLNRDIKSYVSSGVINLDKPSNPSSHEVVAWIKRILRVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHEQLKDDKELNRALENLTGALFQRPPLISAVKRQLRVRTVYDSKLIEFDNKRGLGVFWASCEAGTYMRTLCVHLGMLLGVGGHMQELRRVRSGAMSESDNLVTLHDVLDAQYVYDNTRDESYLRKIIQPLESLLVGYKRVVVKDSAVNSVCYGAKLMIPGLLRYEEGIELYDEVVLMTTKGEAIAIGIAQMSTVDLQSCDHGIVAKVKRCIMERDTYPRRWGLGPIAQKKKQMKADGKLDKYGRV 375
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. UniProt/SwissProt
Match: sp|O60832|DKC1_HUMAN (H/ACA ribonucleoprotein complex subunit DKC1 OS=Homo sapiens OX=9606 GN=DKC1 PE=1 SV=3)

HSP 1 Score: 455.292 bits (1170), Expect = 1.687e-155
Identity = 228/356 (64.04%), Postives = 282/356 (79.21%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRL 1206
            F ++   +   +D S WPLLLKNF K+NVR  H+TP   G +PL+R I +Y+++G INLDKPSNPSSHEVVAW++R L V+KTGHSGTLDPKVTGCLIVC++RATRLVKSQQ+AGKEYV I ++        ++ +ALE + GAL Q PPLI AVKR LR+RT+Y+ K+IEYD +R LG+ WV CEAGTYIRTLCVH+G  LGV   M ELRRVRSG+M+E D+MVT+HDVLDA  +Y  H DESYLRRVV PLE LL  HKR+++KDSAV A+ +GAK+MLPGVLRY++ I VN EIV++TTKGEA+ +AIALMTTA + +CDHG VAK+KRVIMERD Y R+WG G  A+ K+L
Sbjct:   36 FLIKPESKVAKLDTSQWPLLLKNFDKLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKL 391
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. UniProt/SwissProt
Match: sp|Q9ESX5|DKC1_MOUSE (H/ACA ribonucleoprotein complex subunit DKC1 OS=Mus musculus OX=10090 GN=Dkc1 PE=1 SV=4)

HSP 1 Score: 451.825 bits (1161), Expect = 3.004e-154
Identity = 226/356 (63.48%), Postives = 282/356 (79.21%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRL 1206
            F ++   +   +D S WPLLLKNF K+NVR  H+TP   G +PL+R I +Y+++G INLDKPSNPSSHEVVAW++R L V+KTGHSGTLDPKVTGCLIVC++RATRLVKSQQ+AGKEYV I ++        ++ +ALE + GAL Q PPLI AVKR LR+RT+Y+ K+IEYD +R LG+ WV CEAGTYIRTLCVH+G  LGV   M ELRRVRSG+M+E D+MVT+HDVLDA  +Y  H DESYLRRVV PLE LL  HKR+++KDSAV A+ +GAK+MLPG+LRY++ I VN EIV++TTKGEA+ +AIALMTTA + +CDHG VAK+KRVIMERD Y R+WG G  A+ K++
Sbjct:   36 FLIKPESKVAQLDTSQWPLLLKNFDKLNVRTAHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKM 391
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. UniProt/SwissProt
Match: sp|P33322|CBF5_YEAST (H/ACA ribonucleoprotein complex subunit CBF5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CBF5 PE=1 SV=1)

HSP 1 Score: 449.514 bits (1155), Expect = 1.068e-153
Identity = 222/369 (60.16%), Postives = 277/369 (75.07%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRLNSVKSEMNESNKI 1245
            F ++        D S+WPLLLKNF K+ VR  H+TP   G SPL+R +  Y+ SGVINLDKPSNPSSHEVVAW+KR L  +KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ AGKEYV I ++     D K + ++LE + GAL Q PPLI AVKR LR+RT+Y+  LIE+D KR LGV W  CEAGTY+RTLCVH+G  LGV  +M ELRRVRSG ++ENDNMVTLHDV+DA  +Y    DESYLR ++ PLE LLV +KR+++KDSAV AV +GAK+M+PG+LRY+  I + DEIV++TTKGEA+A+AIA M+T  + SCDHG VA +KR IMERDLY R+WG G  A  K+      ++++  ++
Sbjct:    6 FVIKPEAAGASTDTSEWPLLLKNFDKLLVRSGHYTPIPAGSSPLKRDLKSYISSGVINLDKPSNPSSHEVVAWIKRILRCEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDALKDEKDLGRSLENLTGALFQRPPLISAVKRQLRVRTIYESNLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGMLLGVGGHMQELRRVRSGALSENDNMVTLHDVMDAQWVYDNTRDESYLRSIIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRYEEGIELYDEIVLITTKGEAIAVAIAQMSTVDLASCDHGVVASVKRCIMERDLYPRRWGLGPVAQKKKQMKADGKLDKYGRV 374
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. TrEMBL
Match: A0A5J4NG91 (H/ACA ribonucleoprotein complex subunit 4 OS=Paragonimus westermani OX=34504 GN=DEA37_0013826 PE=4 SV=1)

HSP 1 Score: 510.375 bits (1313), Expect = 2.630e-176
Identity = 253/348 (72.70%), Postives = 294/348 (84.48%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYG 1182
            FAV+S ++ P +D S WPLLLKN   MNVRECHF     GFSPL RPIDE++++GVINLDKPSNPSSHEVVAWVKRAL V KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ+AGK Y+ IF++ +   D K+V QA+E + GAL Q PPL+ AVKR LR+RTVY+ KL+EYD+++GLGV+ V CEAGTY+RTLCVHIG  LG    M+ELRRVRSGIMTE DN+VT+HDVLDA  +Y    DESYLRRVVMPLE LL  HKR+M+KD+AV+A+ +GAK+MLPGVLRYDNDINVNDEIV+MTTKGEAVA+AIALMTTAT+ +CDHG VAKLKRVIMERDLY RQWG G
Sbjct:   24 FAVQSENKRPTLDCSQWPLLLKNVHLMNVRECHFEADTTGFSPLHRPIDEHIQTGVINLDKPSNPSSHEVVAWVKRALAVGKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKVYIGIFRLHEALDDQKRVQQAVETLSGALFQRPPLVAAVKRQLRVRTVYENKLLEYDKEKGLGVIRVTCEAGTYVRTLCVHIGLLLGCGGVMEELRRVRSGIMTEEDNLVTMHDVLDAKWLYDNRRDESYLRRVVMPLEKLLTGHKRIMVKDTAVSAICYGAKLMLPGVLRYDNDINVNDEIVLMTTKGEAVAIAIALMTTATIATCDHGLVAKLKRVIMERDLYPRQWGRG 371
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. TrEMBL
Match: A0A4Z2CZT1 (H/ACA ribonucleoprotein complex subunit 4 isoform 1 OS=Schistosoma japonicum OX=6182 GN=EWB00_006312 PE=4 SV=1)

HSP 1 Score: 501.13 bits (1289), Expect = 7.278e-172
Identity = 259/385 (67.27%), Postives = 307/385 (79.74%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYG-VHANTKRL--NSVKSEMNESNKIIAKPVETAISKPV 1284
            FAV   D+ P +D S WPLLLKN   MNVRECHF     GFSPL RP+DEY+KSGVINLDKP NPSSHEVVAWVKRALGV+KTGHSGTLDPKV+GCLIVC+DRATRLVKSQQ+AGKEYV IF++     DVKK+ +A+E + GAL Q PPL+ AVKR LR+RT+Y+ KL+EYD+ R LG++ V+CEAGTY+RTLCVH+G  LG    M+ELRR R+G M+E DN+VT+HD+LDA  +Y    DE+YLRRVVMPLE LLVKHKR+M+KD+AV A+ FGAK+MLPGVLRYDNDINVNDEIV+MTTKGEAVALAIALMTTAT+ +CDHG VAKLKRVIMERDLY RQWG G V    K+L    +  +  +S +I + P    + K V
Sbjct:   22 FAVIPEDKKPTLDCSQWPLLLKNVHLMNVRECHFEADTTGFSPLHRPLDEYIKSGVINLDKPCNPSSHEVVAWVKRALGVNKTGHSGTLDPKVSGCLIVCIDRATRLVKSQQSAGKEYVCIFRLHDSVDDVKKIQKAVEGLTGALFQRPPLVAAVKRQLRVRTIYESKLLEYDKSRNLGLITVRCEAGTYVRTLCVHLGLLLGCGGVMEELRRSRTGFMSERDNLVTMHDILDAKWLYDNRRDETYLRRVVMPLERLLVKHKRIMLKDTAVCAICFGAKLMLPGVLRYDNDINVNDEIVLMTTKGEAVALAIALMTTATIATCDHGLVAKLKRVIMERDLYPRQWGRGPVAMERKKLVAQGLLKKFAKSGEIESTPNSAGLRKEV 406
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. TrEMBL
Match: C7TY50 (Dyskeratosis congenita 1, dyskerin OS=Schistosoma japonicum OX=6182 GN=EWB00_006312 PE=2 SV=1)

HSP 1 Score: 500.745 bits (1288), Expect = 1.047e-171
Identity = 259/385 (67.27%), Postives = 307/385 (79.74%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYG-VHANTKRL--NSVKSEMNESNKIIAKPVETAISKPV 1284
            FAV   D+ P +D S WPLLLKN   MNVRECHF     GFSPL RP+DEY+KSGVINLDKP NPSSHEVVAWVKRALGV+KTGHSGTLDPKV+GCLIVC+DRATRLVKSQQ+AGKEYV IF++     DVKK+ +A+E + GAL Q PPL+ AVKR LR+RT+Y+ KL+EYD+ R LG++ V+CEAGTY+RTLCVH+G  LG    M+ELRR R+G M+E DN+VT+HD+LDA  +Y    DE+YLRRVVMPLE LLVKHKR+M+KD+AV A+ FGAK+MLPGVLRYDNDINVNDEIV+MTTKGEAVALAIALMTTAT+ +CDHG VAKLKRVIMERDLY RQWG G V    K+L    +  +  +S +I + P    + K V
Sbjct:   24 FAVIPEDKKPTLDCSQWPLLLKNVHLMNVRECHFEADTTGFSPLHRPLDEYIKSGVINLDKPCNPSSHEVVAWVKRALGVNKTGHSGTLDPKVSGCLIVCIDRATRLVKSQQSAGKEYVCIFRLHDSVDDVKKIQKAVEGLTGALFQRPPLVAAVKRQLRVRTIYESKLLEYDKSRNLGLITVRCEAGTYVRTLCVHLGLLLGCGGVMEELRRSRTGFMSERDNLVTMHDILDAKWLYDNRRDETYLRRVVMPLERLLVKHKRIMLKDTAVCAICFGAKLMLPGVLRYDNDINVNDEIVLMTTKGEAVALAIALMTTATIATCDHGLVAKLKRVIMERDLYPRQWGRGPVAMERKKLVAQGLLKKFAKSGEIESTPNSAGLRKEV 408
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. TrEMBL
Match: Q5D8W5 (SJCHGC01561 protein OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 500.36 bits (1287), Expect = 1.260e-171
Identity = 259/385 (67.27%), Postives = 307/385 (79.74%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYG-VHANTKRL--NSVKSEMNESNKIIAKPVETAISKPV 1284
            FAV   D+ P +D S WPLLLKN   MNVRECHF     GFSPL RP+DEY+KSGVINLDKP NPSSHEVVAWVKRALGV+KTGHSGTLDPKV+GCLIVC+DRATRLVKSQQ+AGKEYV IF++     DVKK+ +A+E + GAL Q PPL+ AVKR LR+RT+Y+ KL+EYD+ R LG++ V+CEAGTY+RTLCVH+G  LG    M+ELRR R+G M+E DN+VT+HD+LDA  +Y    DE+YLRRVVMPLE LLVKHKR+M+KD+AV A+ FGAK+MLPGVLRYDNDINVNDEIV+MTTKGEAVALAIALMTTAT+ +CDHG VAKLKRVIMERDLY RQWG G V    K+L    +  +  +S +I + P    + K V
Sbjct:   24 FAVIPEDKKPTLDCSQWPLLLKNVHLMNVRECHFEADTTGFSPLHRPLDEYIKSGVINLDKPCNPSSHEVVAWVKRALGVNKTGHSGTLDPKVSGCLIVCIDRATRLVKSQQSAGKEYVCIFRLHDSVDDVKKIQKAVEGLTGALFQRPPLVAAVKRQLRVRTIYESKLLEYDKSRNLGLITVRCEAGTYVRTLCVHLGLLLGCGGVMEELRRSRTGFMSERDNLVTMHDILDAKWLYDNRRDETYLRRVVMPLERLLVKHKRIMLKDTAVCAICFGAKLMLPGVLRYDNDINVNDEIVLMTTKGEAVALAIALMTTATIATCDHGLVAKLKRVIMERDLYPRQWGRGPVAMERKKLVAQGLLKKFAKSGEIESTPNSAGLRKEV 408
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. TrEMBL
Match: C1LDI2 (Dyskeratosis congenita 1, dyskerin OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 500.36 bits (1287), Expect = 1.468e-171
Identity = 259/385 (67.27%), Postives = 307/385 (79.74%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYG-VHANTKRL--NSVKSEMNESNKIIAKPVETAISKPV 1284
            FAV   D+ P +D S WPLLLKN   MNVRECHF     GFSPL RP+DEY+KSGVINLDKP NPSSHEVVAWVKRALGV+KTGHSGTLDPKV+GCLIVC+DRATRLVKSQQ+AGKEYV IF++     DVKK+ +A+E + GAL Q PPL+ AVKR LR+RT+Y+ KL+EYD+ R LG++ V+CEAGTY+RTLCVH+G  LG    M+ELRR R+G M+E DN+VT+HD+LDA  +Y    DE+YLRRVVMPLE LLVKHKR+M+KD+AV A+ FGAK+MLPGVLRYDNDINVNDEIV+MTTKGEAVALAIALMTTAT+ +CDHG VAKLKRVIMERDLY RQWG G V    K+L    +  +  +S +I + P    + K V
Sbjct:   24 FAVIPEDKKPTLDCSQWPLLLKNVHLMNVRECHFEADTTGFSPLHRPLDEYIKSGVINLDKPCNPSSHEVVAWVKRALGVNKTGHSGTLDPKVSGCLIVCIDRATRLVKSQQSAGKEYVCIFRLHDSVDDVKKIQKAVEGLTGALFQRPPLVAAVKRQLRVRTIYESKLLEYDKSRNLGLITVRCEAGTYVRTLCVHLGLLLGCGGVMEELRRSRTGFMSERDNLVTMHDILDAKWLYDNRRDETYLRRVVMPLERLLVKHKRIMLKDTAVCAICFGAKLMLPGVLRYDNDINVNDEIVLMTTKGEAVALAIALMTTATIATCDHGLVAKLKRVIMERDLYPRQWGRGPVAMERKKLVAQGLLKKFAKSGEIESTPNSVGLRKEV 408
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Cavefish
Match: dkc1 (dyskerin pseudouridine synthase 1 [Source:NCBI gene;Acc:103033637])

HSP 1 Score: 442.965 bits (1138), Expect = 1.085e-151
Identity = 223/368 (60.60%), Postives = 285/368 (77.45%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRLNSVKSEMNESNK 1242
            F ++   +   +D S WPLLLKNF K+N+R  H+TP   G +PL+R I +Y++SG INLDKP+NPSSHEVVAW+KR L V+KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ+AGKEYV I ++     +  ++ +ALE + GAL Q PPLI AVKR LR+RT+Y+ KLIEYD +R LG+ WV CEAGTYIRTLCVH+G  LGV   M ELRRVRSG++ E D MVT+HDVLDA   +  + DE+YLRRV+ PLE LL+ HKR+++KDSAV A+ +GAK+MLPGVLRY++ I +N +IV++TTKGEA+  A+ALMTTA + +CDHG VAK+KRVIMERD Y R+WG G  A+ K++   K  +++  K
Sbjct:   35 FLIKPESKVAKLDTSQWPLLLKNFDKLNIRTAHYTPLPHGSNPLKRNIHDYVRSGFINLDKPANPSSHEVVAWIKRILRVEKTGHSGTLDPKVTGCLIVCVDRATRLVKSQQSAGKEYVGIVRLHNAIENEHQLARALECLTGALFQRPPLIAAVKRQLRVRTIYESKLIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVLGEKDCMVTMHDVLDAQWQFDHNKDETYLRRVIYPLEKLLISHKRIVMKDSAVNAICYGAKIMLPGVLRYEDGIEMNQDIVVITTKGEAICTAVALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKKMMIQKGLLDKHGK 402
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Cavefish
Match: dkc1 (dyskerin pseudouridine synthase 1 [Source:NCBI gene;Acc:103033637])

HSP 1 Score: 442.965 bits (1138), Expect = 1.266e-151
Identity = 223/368 (60.60%), Postives = 285/368 (77.45%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRLNSVKSEMNESNK 1242
            F ++   +   +D S WPLLLKNF K+N+R  H+TP   G +PL+R I +Y++SG INLDKP+NPSSHEVVAW+KR L V+KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ+AGKEYV I ++     +  ++ +ALE + GAL Q PPLI AVKR LR+RT+Y+ KLIEYD +R LG+ WV CEAGTYIRTLCVH+G  LGV   M ELRRVRSG++ E D MVT+HDVLDA   +  + DE+YLRRV+ PLE LL+ HKR+++KDSAV A+ +GAK+MLPGVLRY++ I +N +IV++TTKGEA+  A+ALMTTA + +CDHG VAK+KRVIMERD Y R+WG G  A+ K++   K  +++  K
Sbjct:   33 FLIKPESKVAKLDTSQWPLLLKNFDKLNIRTAHYTPLPHGSNPLKRNIHDYVRSGFINLDKPANPSSHEVVAWIKRILRVEKTGHSGTLDPKVTGCLIVCVDRATRLVKSQQSAGKEYVGIVRLHNAIENEHQLARALECLTGALFQRPPLIAAVKRQLRVRTIYESKLIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVLGEKDCMVTMHDVLDAQWQFDHNKDETYLRRVIYPLEKLLISHKRIVMKDSAVNAICYGAKIMLPGVLRYEDGIEMNQDIVVITTKGEAICTAVALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKKMMIQKGLLDKHGK 400
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Cavefish
Match: trub1 (TruB pseudouridine synthase family member 1 [Source:NCBI gene;Acc:103047233])

HSP 1 Score: 65.855 bits (159), Expect = 1.698e-11
Identity = 55/218 (25.23%), Postives = 94/218 (43.12%), Query Frame = 1 
Query:  298 SGVINLDKPSNPSSHEVVAWVKRAL----GVD------------KTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPG-----------------IDVKKVHQALEKVKGALLQLPPLICAVK------------------RTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMT 798
            +G+ ++ K   P+S +V+  +K  L    GV             K GH GTLD   +G L+V +   T+++ +     K+Y A+ ++ K                   I  +   + L++  G ++Q+PPL  A+K                  +  R  TVY+L L +++    L  L V+C  G Y+R+L   +G  L   A++ EL R + G  T
Sbjct:   16 NGIFSIYKKQGPTSADVLNTLKNKLLKEAGVANPNCRKRKKQAVKIGHGGTLDSNASGVLVVGIGEGTKMLTTMLAGSKKYTAVGELGKATDTLDCTGSVVQENNYDHITREAFEEKLKEFTGEIMQVPPLYSALKKDGKRLSVLLKQGQEVEAKPARPVTVYNLTLQDFNPP--LFTLDVECGGGFYVRSLVDDLGKALSSCAHIRELIRTKQGQFT 231
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Yeast
Match: CBF5 (Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs; acts on large and small rRNAs, on snRNA U2, and on some mRNAs; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita; small nucleolar ribonucleoprotein particles are also known as snoRNPs [Source:SGD;Acc:S000004165])

HSP 1 Score: 449.514 bits (1155), Expect = 1.538e-155
Identity = 222/369 (60.16%), Postives = 277/369 (75.07%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRLNSVKSEMNESNKI 1245
            F ++        D S+WPLLLKNF K+ VR  H+TP   G SPL+R +  Y+ SGVINLDKPSNPSSHEVVAW+KR L  +KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ AGKEYV I ++     D K + ++LE + GAL Q PPLI AVKR LR+RT+Y+  LIE+D KR LGV W  CEAGTY+RTLCVH+G  LGV  +M ELRRVRSG ++ENDNMVTLHDV+DA  +Y    DESYLR ++ PLE LLV +KR+++KDSAV AV +GAK+M+PG+LRY+  I + DEIV++TTKGEA+A+AIA M+T  + SCDHG VA +KR IMERDLY R+WG G  A  K+      ++++  ++
Sbjct:    6 FVIKPEAAGASTDTSEWPLLLKNFDKLLVRSGHYTPIPAGSSPLKRDLKSYISSGVINLDKPSNPSSHEVVAWIKRILRCEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDALKDEKDLGRSLENLTGALFQRPPLISAVKRQLRVRTIYESNLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGMLLGVGGHMQELRRVRSGALSENDNMVTLHDVMDAQWVYDNTRDESYLRSIIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRYEEGIELYDEIVLITTKGEAIAVAIAQMSTVDLASCDHGVVASVKRCIMERDLYPRRWGLGPVAQKKKQMKADGKLDKYGRV 374
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Nematostella
Match: EDO45197 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTE5])

HSP 1 Score: 454.136 bits (1167), Expect = 2.711e-158
Identity = 226/355 (63.66%), Postives = 279/355 (78.59%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKR 1203
            F ++ T  A  +D S WPLLLKN+ K+N+R  HFTP   G SPL+R I +Y+ SG INLDKP+NPSSHEVVAW++R L V+KTGHSGTLDPKVTGCLIVC+D+ATRLVKSQQ AGKEYV I ++        ++ + +E + GAL Q PPLI AVKR LRIRT+Y+ KL+EYD++R LGV WV CEAGTYIRTLCVHIG  +G+ A+M ELRRVRSGI +ENDNM T+HDVLDA  +Y    DE+YLRR + PLE LL  HKR+++KDSAV A+ +GAK+M+PG+LRY++ I +N++IVIMTTKGEA+AL IALMTTA M +CDHG VAK+KRVIMERD Y R+WG G  A  K+
Sbjct:    8 FHLKPTKEAGVLDTSQWPLLLKNYDKLNIRTGHFTPLPNGCSPLKREIKDYISSGFINLDKPANPSSHEVVAWLRRILRVEKTGHSGTLDPKVTGCLIVCIDKATRLVKSQQGAGKEYVCIVRLHNAIEGQAELAKTIETLTGALFQRPPLISAVKRQLRIRTIYESKLLEYDDERHLGVFWVSCEAGTYIRTLCVHIGLLMGIGAHMQELRRVRSGIQSENDNMATMHDVLDAQWVYDNSKDETYLRRCIKPLEALLTSHKRLVVKDSAVNAICYGAKLMIPGLLRYESGIEINEQIVIMTTKGEAIALGIALMTTAVMAACDHGIVAKIKRVIMERDTYPRKWGLGPKALKKK 362
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Nematostella
Match: EDO27406 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T9C1])

HSP 1 Score: 68.5514 bits (166), Expect = 1.350e-13
Identity = 49/171 (28.65%), Postives = 74/171 (43.27%), Query Frame = 1 
Query:  382 KTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKI--TKPGIDVKK---------------VHQALEKVKGALLQLPPLICAVKRT-----------------LRIRTVYDLKLIEYDEKRGLGV-LWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSG 789
            K GH+GTLDP  +G LI+C  + T+ +   Q   KEY   F I  T P  D++                +H+  E+  G++ Q PP+  A+K+                   R  T+ + ++   D    L +   V C  GTYIR+L    G  L   A++  LRR + G
Sbjct:    2 KVGHAGTLDPLASGLLIICTGKQTKNISEYQGQVKEYTGTFTIGSTTPSYDLETEVNQTFSTTHITKELIHKTTEQFIGSIQQQPPIFSALKKDGKRLYELARKGETTEIPTREITISEFEITSIDR---LKIDFRVVCSKGTYIRSLANDFGKALQSGAHLSALRRTKIG 169
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Medaka
Match: dkc1 (dyskerin pseudouridine synthase 1 [Source:NCBI gene;Acc:101159315])

HSP 1 Score: 444.121 bits (1141), Expect = 3.058e-152
Identity = 222/355 (62.54%), Postives = 279/355 (78.59%), Query Frame = 1 
Query:  139 FAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKR 1203
            F ++   +A  ++ S WPLLLKNF K+NVR  H+TP   G +PL+R I +Y++SG INLDKP+NPSSHEVVAW++R L V+KTGHSGTLDPKVTGCLIVC+DRATRLVKSQQ+AGKEYV I ++     +   + +ALE + GAL Q PPLI AVKR LR+RT+Y+ KLIEYD +R LG+ WV CEAGTYIRTLCVH+G  LGV   M ELRRVRSG++ E DNMVT+HDVLDA   +  + DE+YLRRV+ PLE LLV H+R+++KDS+V A+ +GAK+MLPGVLRY++ I VN +IV++TTKGEA+  A+ALMTTA + +CDHG VAK+KRVIMERD Y R+WG G  A  K+
Sbjct:   42 FFIQPESKATSLNTSQWPLLLKNFDKLNVRTGHYTPLPNGSNPLKRNIADYVRSGFINLDKPANPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQSAGKEYVGIVRLHNAVENQHALARALETLTGALFQRPPLIAAVKRQLRVRTIYESKLIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVLGEKDNMVTMHDVLDAQWQFDHNKDETYLRRVIFPLEKLLVSHRRLVMKDSSVNAICYGAKIMLPGVLRYEDGIEVNQDIVVITTKGEAICTAVALMTTAVISTCDHGFVAKIKRVIMERDTYPRKWGLGPKATQKK 396
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Medaka
Match: trub1 (TruB pseudouridine synthase family member 1 [Source:NCBI gene;Acc:105354521])

HSP 1 Score: 61.6178 bits (148), Expect = 3.209e-10
Identity = 63/236 (26.69%), Postives = 102/236 (43.22%), Query Frame = 1 
Query:  301 GVINLDKPSNPSSHEVVAWVKRAL----GVD------------KTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPG-----------------IDVKKVHQALEKVKGALLQLPPLICAVK------------------RTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMV-----TLHDVLDA 840
            G+  + K   P+S +V+  +K AL    GV+            K GH GTLD   +G L+V +   T+++ S     K+YVA+ ++ K                   I    V + L+   G ++Q+PPL  A+K                  +  R  TVY L L E+     L  L ++C  G Y+R+L   +G  L   A++ EL R + G  T  ++++     TL ++L A
Sbjct:   24 GMFAIYKKKGPTSADVLNALKEALLKEAGVETPNPRKRKKQWLKMGHGGTLDSAASGVLVVGVGDGTKMLSSMLTGSKKYVAVGELGKATDTLDATGSVVLEKGFEHITRLDVEEKLKSFTGDIMQVPPLFSALKQDGQRLSVLLKKGHKVEAKPARPVTVYSLTLQEFTPP--LFTLDIECGGGFYVRSLVDELGKALSSCAHVKELVRTKQGPFTLQEHVLHEQQWTLENILQA 257
[Close]
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Planmine SMEST
Match: SMESG000029771.1 (SMESG000029771.1)

HSP 1 Score: 762.681 bits (1968), Expect = 0.000e+0
Identity = 385/386 (99.74%), Postives = 385/386 (99.74%), Query Frame = 1 
Query:  136 TFAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEXXXXXXXXXXXXXXXSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRLNSVKSEMNESNKIIAKPVETAISKPVVET 1293
            TFAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEAVALAIALMTTATMLSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRLNSVKSEMNESNKIIAKPVETA SKPVVET
Sbjct:   12 TFAVESTDRAPPIDGSDWPLLLKNFQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAWVKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFKITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYDEKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTENDNMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAAVTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEAVALAIALMTTATMLSCDHGCVAKLKRVIMERDLYSRQWGYGVHANTKRLNSVKSEMNESNKIIAKPVETATSKPVVET 397
The following BLAST results are available for this feature:
BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
DKC11.883e-15664.04dyskerin pseudouridine synthase 1 [Source:HGNC Sym... [more]
DKC13.513e-15664.04dyskerin pseudouridine synthase 1 [Source:HGNC Sym... [more]
DKC14.966e-9052.85dyskerin pseudouridine synthase 1 [Source:HGNC Sym... [more]
DKC18.963e-8459.62dyskerin pseudouridine synthase 1 [Source:HGNC Sym... [more]
DKC19.123e-7067.23dyskerin pseudouridine synthase 1 [Source:HGNC Sym... [more]
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
K01G5.52.270e-15260.67Putative H/ACA ribonucleoprotein complex subunit 4... [more]
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Nop60B2.041e-16467.04gene:FBgn0259937 transcript:FBtr0072258[more]
Nop60B2.041e-16467.04gene:FBgn0259937 transcript:FBtr0300861[more]
Nop60B2.041e-16467.04gene:FBgn0259937 transcript:FBtr0300227[more]
Nop60B2.041e-16467.04gene:FBgn0259937 transcript:FBtr0100213[more]
Nop60B5.370e-8264.55gene:FBgn0259937 transcript:FBtr0304599[more]
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
dkc18.366e-15360.60dyskeratosis congenita 1, dyskerin [Source:ZFIN;Ac... [more]
trub11.649e-1125.00TruB pseudouridine (psi) synthase family member 1 ... [more]
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
wbp2nl1.217e-15961.14WBP2 N-terminal like [Source:Xenbase;Acc:XB-GENE-9... [more]
wbp2nl6.342e-15961.14WBP2 N-terminal like [Source:Xenbase;Acc:XB-GENE-9... [more]
wbp2nl1.266e-15862.64WBP2 N-terminal like [Source:Xenbase;Acc:XB-GENE-9... [more]
wbp2nl2.478e-15861.14WBP2 N-terminal like [Source:Xenbase;Acc:XB-GENE-9... [more]
wbp2nl3.100e-15861.14WBP2 N-terminal like [Source:Xenbase;Acc:XB-GENE-9... [more]
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Dkc14.295e-15563.48dyskeratosis congenita 1, dyskerin [Source:MGI Sym... [more]
Dkc13.065e-9052.45dyskeratosis congenita 1, dyskerin [Source:MGI Sym... [more]
Dkc17.412e-4966.09dyskeratosis congenita 1, dyskerin [Source:MGI Sym... [more]
Dkc15.544e-3561.70dyskeratosis congenita 1, dyskerin [Source:MGI Sym... [more]
Trub11.796e-1427.52TruB pseudouridine (psi) synthase family member 1 ... [more]
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O44081|DKC1_DROME2.046e-16367.04H/ACA ribonucleoprotein complex subunit 4 OS=Droso... [more]
sp|O43101|CBF5_CANAL6.508e-15761.25H/ACA ribonucleoprotein complex subunit CBF5 OS=Ca... [more]
sp|O60832|DKC1_HUMAN1.687e-15564.04H/ACA ribonucleoprotein complex subunit DKC1 OS=Ho... [more]
sp|Q9ESX5|DKC1_MOUSE3.004e-15463.48H/ACA ribonucleoprotein complex subunit DKC1 OS=Mu... [more]
sp|P33322|CBF5_YEAST1.068e-15360.16H/ACA ribonucleoprotein complex subunit CBF5 OS=Sa... [more]
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5J4NG912.630e-17672.70H/ACA ribonucleoprotein complex subunit 4 OS=Parag... [more]
A0A4Z2CZT17.278e-17267.27H/ACA ribonucleoprotein complex subunit 4 isoform ... [more]
C7TY501.047e-17167.27Dyskeratosis congenita 1, dyskerin OS=Schistosoma ... [more]
Q5D8W51.260e-17167.27SJCHGC01561 protein OS=Schistosoma japonicum OX=61... [more]
C1LDI21.468e-17167.27Dyskeratosis congenita 1, dyskerin OS=Schistosoma ... [more]
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
dkc11.085e-15160.60dyskerin pseudouridine synthase 1 [Source:NCBI gen... [more]
dkc11.266e-15160.60dyskerin pseudouridine synthase 1 [Source:NCBI gen... [more]
trub11.698e-1125.23TruB pseudouridine synthase family member 1 [Sourc... [more]
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
CBF51.538e-15560.16Pseudouridine synthase catalytic subunit of box H/... [more]
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO451972.711e-15863.66Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO274061.350e-1328.65Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
dkc13.058e-15262.54dyskerin pseudouridine synthase 1 [Source:NCBI gen... [more]
trub13.209e-1026.69TruB pseudouridine synthase family member 1 [Sourc... [more]
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BLAST of H/ACA ribonucleoprotein complex subunit 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000029771.10.000e+099.74SMESG000029771.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30025222 ID=SMED30025222|Name=H/ACA ribonucleoprotein complex subunit 4|organism=Schmidtea mediterranea sexual|type=transcript|length=1469bp
ATTTTTTGAAAAAAGTAATTAAAAAATTTTGACAATTTAAAAAAATTTGT
TTAACTAATGATTAATTTAAATTATATCAAATTTAAAAAAACATTGTCTA
AAATGCCGAAAGATAAATCTTCTAAAAAATCAAAGACCTTTGCTGTTGAA
TCGACGGATCGTGCTCCTCCTATTGATGGATCTGACTGGCCATTATTATT
AAAAAATTTTCAAAAAATGAATGTACGAGAGTGCCATTTTACTCCAAGTG
ATAAAGGATTTTCTCCTTTACAAAGACCAATTGATGAATATTTAAAGAGT
GGTGTTATAAACCTCGACAAACCTTCTAATCCCTCTTCCCATGAAGTCGT
AGCTTGGGTTAAAAGGGCTTTAGGTGTTGACAAAACTGGTCATAGTGGTA
CCCTAGATCCTAAAGTTACCGGTTGTTTAATTGTTTGTCTCGATAGAGCT
ACTCGTTTAGTGAAAAGCCAACAAAATGCTGGCAAAGAATATGTTGCAAT
TTTTAAAATTACCAAACCGGGTATTGATGTCAAAAAAGTTCATCAAGCAC
TTGAAAAAGTTAAAGGTGCTTTATTACAGTTACCACCTTTAATATGCGCA
GTTAAAAGAACGCTTAGAATCCGAACTGTTTATGATTTAAAGTTGATTGA
GTATGATGAGAAAAGAGGTTTGGGAGTTCTTTGGGTCAAGTGCGAAGCAG
GAACCTATATTAGAACATTATGTGTTCATATCGGGTTCCATTTGGGGGTT
GTAGCATATATGGATGAACTAAGGAGAGTTCGATCCGGGATTATGACAGA
AAATGATAATATGGTAACACTACATGACGTACTTGATGCTGCGCATATGT
ATAAAAAACATAACGATGAAAGTTATTTGAGACGTGTTGTAATGCCCCTT
GAAATATTATTAGTCAAACACAAAAGAGTAATGATCAAAGACTCCGCAGT
GGCAGCTGTTACTTTCGGTGCCAAAGTTATGCTACCTGGAGTTTTGAGAT
ACGACAATGATATAAATGTCAACGATGAAATTGTTATAATGACAACAAAA
GGAGAAGCTGTCGCATTAGCTATTGCATTAATGACCACTGCCACGATGTT
ATCATGTGATCATGGGTGTGTAGCTAAATTAAAACGAGTTATTATGGAAC
GAGATTTATATTCACGTCAATGGGGTTACGGAGTCCACGCAAATACTAAA
AGGTTAAATAGTGTCAAATCAGAAATGAACGAGTCAAACAAAATTATTGC
TAAACCTGTAGAAACCGCCATTTCAAAACCAGTTGTGGAGACTTCAATTA
AGAAGGCCAAAATAGAAGAGAAAGCTAAACCAGAGTCATCAAGCAGTGAA
GATAGTGACAGTGATTAAAAAATATATATTGACGTAGCTTGTTCATTCGT
TGTATAAATAAACTGCTTTCTGTGTCGGTATTTTGATATATTATCCTATA
ACTTTGTTAAGTAAATAAC
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protein sequence of SMED30025222-orf-1

>SMED30025222-orf-1 ID=SMED30025222-orf-1|Name=SMED30025222-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=437bp
MINLNYIKFKKTLSKMPKDKSSKKSKTFAVESTDRAPPIDGSDWPLLLKN
FQKMNVRECHFTPSDKGFSPLQRPIDEYLKSGVINLDKPSNPSSHEVVAW
VKRALGVDKTGHSGTLDPKVTGCLIVCLDRATRLVKSQQNAGKEYVAIFK
ITKPGIDVKKVHQALEKVKGALLQLPPLICAVKRTLRIRTVYDLKLIEYD
EKRGLGVLWVKCEAGTYIRTLCVHIGFHLGVVAYMDELRRVRSGIMTEND
NMVTLHDVLDAAHMYKKHNDESYLRRVVMPLEILLVKHKRVMIKDSAVAA
VTFGAKVMLPGVLRYDNDINVNDEIVIMTTKGEAVALAIALMTTATMLSC
DHGCVAKLKRVIMERDLYSRQWGYGVHANTKRLNSVKSEMNESNKIIAKP
VETAISKPVVETSIKKAKIEEKAKPESSSSEDSDSD*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000429neoblast
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR004521Uncharacterised_CHP00451
IPR004802tRNA_PsdUridine_synth_B_fam
IPR012960Dyskerin-like
IPR002478PUA
IPR032819TruB_C
IPR015947PUA-like_sf
IPR002501PsdUridine_synth_N
IPR020103PsdUridine_synth_cat_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0003723RNA binding
GO:0009982pseudouridine synthase activity
GO:0016853isomerase activity
Vocabulary: biological process
TermDefinition
GO:0006396RNA processing
GO:0001522pseudouridine synthesis
GO:0009451RNA modification
GO:0000495box H/ACA snoRNA 3'-end processing
GO:0006364rRNA processing
GO:0007281germ cell development
GO:0009267cellular response to starvation
GO:0022008neurogenesis
GO:0031118rRNA pseudouridine synthesis
GO:0031120snRNA pseudouridine synthesis
GO:0035220wing disc development
GO:0042254ribosome biogenesis
GO:1990481mRNA pseudouridine synthesis
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005730nucleolus
GO:0030529intracellular ribonucleoprotein complex
GO:0031429box H/ACA snoRNP complex
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR012960Dyskerin-likeSMARTSM01136DKCLD_2coord: 40..98
e-value: 1.8E-29
score: 113.9
IPR012960Dyskerin-likePFAMPF08068DKCLDcoord: 42..98
e-value: 1.5E-30
score: 105.0
IPR002478PUA domainSMARTSM00359pua_5coord: 289..363
e-value: 3.5E-18
score: 76.4
IPR002478PUA domainPFAMPF01472PUAcoord: 289..362
e-value: 2.9E-18
score: 65.6
IPR002478PUA domainPROSITEPS50890PUAcoord: 288..363
score: 16.176
IPR032819tRNA pseudouridylate synthase B, C-terminalPFAMPF16198TruB_C_2coord: 219..285
e-value: 2.9E-20
score: 72.2
IPR004521Uncharacterised domain CHP00451TIGRFAMTIGR00451TIGR00451coord: 284..359
e-value: 2.1E-10
score: 38.7
IPR004802tRNA pseudouridine synthase B familyTIGRFAMTIGR00425TIGR00425coord: 48..373
e-value: 5.4E-142
score: 470.6
IPR004802tRNA pseudouridine synthase B familyPANTHERPTHR23127CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5coord: 12..431
IPR002501Pseudouridine synthase II, N-terminalPFAMPF01509TruB_Ncoord: 102..218
e-value: 1.9E-18
score: 67.3
NoneNo IPR availableGENE3DG3DSA:3.30.2350.10coord: 74..280
e-value: 1.5E-156
score: 522.5
NoneNo IPR availableGENE3DG3DSA:2.30.130.70coord: 43..372
e-value: 1.5E-156
score: 522.5
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 413..436
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 397..436
NoneNo IPR availablePANTHERPTHR23127:SF0H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 4coord: 12..431
NoneNo IPR availableCDDcd02572PseudoU_synth_hDyskerincoord: 80..261
e-value: 2.03066E-119
score: 343.86
IPR015947PUA-like superfamilySUPERFAMILYSSF88697PUA domain-likecoord: 288..368
IPR020103Pseudouridine synthase, catalytic domain superfamilySUPERFAMILYSSF55120Pseudouridine synthasecoord: 43..286