Fzd-1/2/7

Overview
NameFzd-1/2/7
Smed IDSMED30025215
Length (bp)2307
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Fzd-1/2/7 (SMED30025215) t-SNE clustered cells

Violin plots show distribution of expression levels for Fzd-1/2/7 (SMED30025215) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Fzd-1/2/7 (SMED30025215) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Fzd-1/2/7 (SMED30025215) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30025215

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 12

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
muscle cellSMED30025215h1SMcG0010782 dd_Smed_v4_6353_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
pharynxSMED30025215h1SMcG0010782 dd_Smed_v6_6353_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult colorimetric in situ hybridization evidence
cephalic gangliaSMED30025215h1SMcG0010782 dd_Smed_v6_6353_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult colorimetric in situ hybridization evidence
central nervous systemSMED30025215h1SMcG0010782 dd_Smed_v6_6353_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult colorimetric in situ hybridization evidence
whole organismSMED30025215h1SMcG0010782 dd_Smed_v6_6353_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult colorimetric in situ hybridization evidence
head regionSMED30025215h1SMcG0010782 dd_Smed_v6_6353_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult colorimetric in situ hybridization evidence
parapharyngeal regionSMED30025215h1SMcG0010782 dd_Smed_v6_6353_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult colorimetric in situ hybridization evidence
tail regionSMED30025215h1SMcG0010782 dd_Smed_v6_6353_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult colorimetric in situ hybridization evidence
head marginSMED30025215h1SMcG0010782 dd_Smed_v6_6353_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult colorimetric in situ hybridization evidence
pharynx tipSMED30025215h1SMcG0010782 dd_Smed_v6_6353_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult colorimetric in situ hybridization evidence
epidermisSMED30025215h1SMcG0010782 dd_Smed_v4_6353_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
central nervous systemSMED30025215h1SMcG0010782 DN316513smed_ncbi_20240424PMID:16890156
Guo et al., 2006
whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Fzd-1/2/7 vs. Ensembl Human
Match: FZD1 (frizzled class receptor 1 [Source:HGNC Symbol;Acc:HGNC:4038])

HSP 1 Score: 502.286 bits (1292), Expect = 1.328e-168
Identity = 263/556 (47.30%), Postives = 355/556 (63.85%), Query Frame = 3
Query:   78 NNIRAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP---ENNLCIRDNQTEKESAPNVSL--------------------------------SCPKSLQIPVSYDFKIRLSQNSVIQDCGIPC------NRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            N  R ++ P +   C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++ALPPCRSLC + ++ CE ++ KF F+WP ++ C+ +P      LC+  N ++K   P  SL                                SCP++L++P   ++   L +    +DCG PC         YF    LR F+R W+ +WS +C  STLFTVLT+L+DM+RF YPERPIIFLS CY  V + Y+AGF L D+V C   F    +     + V QGTK E C ILFM+LYFFSMAS+IWWV+L++TW+LAA   W HE+I  NSQYFH AAWA+PA KTI ILAL +VDGD L+GVCF GL++   LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIG+FSVLY VPA +VIACYF+E     +W + W +   C+S  Y   C  +        GG        P+F +FMIKYLM+LIVGITSG WIWSGKTL SW+ F++RL
Sbjct:  103 NGERGISVP-DHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDK-GTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHF-LGE----KDCGAPCEPTKVYGLMYFGPEELR-FSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGA-----RTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSW-VAQSCKS--YAIPCPHLQAG-----GGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRL 637          
BLAST of Fzd-1/2/7 vs. Ensembl Human
Match: FZD7 (frizzled class receptor 7 [Source:HGNC Symbol;Acc:HGNC:4045])

HSP 1 Score: 488.804 bits (1257), Expect = 1.899e-164
Identity = 252/542 (46.49%), Postives = 345/542 (63.65%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP---ENNLCIRDNQTEK--------------------------------ESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPC------NRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++ +A+PPCRSLC + ++ CE ++ KF F+WP+ + C+ +P      +C+  N ++                                    P    SCP+ L++P    ++  L +    +DCG PC         YF E   R+FAR+WV +WS +C  STLFTVLT+L+DM+RF YPERPIIFLS CY +V + +VAGF L D+  C   F++        + V QGTK E C ILFM+LYFF MAS+IWWV+L++TW+LAA   W HE+I  NSQYFH AAWA+PA KTI ILA+ +VDGD L+GVC+ GLS    LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIG+FSVLY VPA +V+ACYF+E      W + W L+  C+S  Y   C   H   P++           P+F +FMIKYLM++IVGIT+G WIWSGKTL SW+ F+ RL
Sbjct:   49 CQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRF-LGE----RDCGAPCEPGRANGLMYFKEEE-RRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGY-----RTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTW-LLQTCKS--YAVPCPPGH-FPPMS-----------PDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRL 564          
BLAST of Fzd-1/2/7 vs. Ensembl Human
Match: FZD2 (frizzled class receptor 2 [Source:HGNC Symbol;Acc:HGNC:4040])

HSP 1 Score: 475.322 bits (1222), Expect = 2.776e-159
Identity = 246/543 (45.30%), Postives = 343/543 (63.17%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPEN---NLCIRDNQTEK------ESAPNVSLS---------------------------CPKSLQIPVSYDFKIRLSQNSVIQDCGIPCN------RYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++A+PPCRS+C + ++ CE ++ KF F+WP+ + C+ +P +    +C+  N +E        +AP   L                            CP+ L++P    +K  L +    +DC  PC         +F++   R FAR+W+  WS +C  ST FTV T+L+DM+RF+YPERPIIFLS CY +V + Y+AGF L ++V C   F+         + VVQGTK E C ILFM+LYFFSMAS+IWWV+L++TW+LAA   W HE+I  NSQYFH AAWA+PA KTI ILA+ ++DGD L+GVCF GL+    LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLE+L+ RIG+FSVLY VPA +VIACYF+E      W + W              CK +    P +           P+F ++MIKYLM+LIVGITSG WIWSGKTL SW+ F++RL
Sbjct:   39 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPPGLQPGAGGTPGGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKF-LGE----RDCAAPCEPARPDGSMFFSQEETR-FARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSEDGY-----RTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSW----------VSQHCKSLAIPCPAH-----YTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRL 555          
BLAST of Fzd-1/2/7 vs. Ensembl Human
Match: FZD5 (frizzled class receptor 5 [Source:HGNC Symbol;Acc:HGNC:4043])

HSP 1 Score: 421.779 bits (1083), Expect = 2.981e-138
Identity = 233/550 (42.36%), Postives = 323/550 (58.73%), Query Frame = 3
Query:  108 NQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVC-TIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP-----ENNLCIRDNQTEKESAPNVSLSCPKSL-----------QIPVSYDF--------------------KIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFL-NDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLNPG 1643
              P C++I VP C+G+ Y +T  PN   H TQDEA LE++++ PL+ I+C   L+ FLCS+Y P+C     K LPPCRS+C + K  C P+++++ F WP+ MSCD  P        LC+  N++E  +AP        +L           + P    F                    K+R  Q   + +C +PC +  F+  + R FA  W+ LWS +C  ST  TV TFLIDM+RF+YPERPIIFLSACYL V L ++    + +  VAC+    +       P +         C I+F+L+YFF MAS+IWWV+L++TW+LAA   W +E+I   +QYFH AAW IP+ K+I  LALS VDGDP+ G+C+ G  + ++LRGF++ PL +YLL+GT FL+AGFVS+F IR++IK GG+KTDKLEKL+ RIGIF++LY VPA +V+ACY +E      + + W     C                   PG +      KPE+ + M+KY M L+VGITSG+WIWSGKT+ SW+ F SR C R   G
Sbjct:   29 KAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLPGPPGAPASGGECPAGGPFVCKCREPFVPILKESHPLYNKVRTGQ---VPNCAVPCYQPSFSA-DERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREHNHIHYETTGPAL---------CTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQ----HYRESWEAALTCAC-----------------PGHDTGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSRCCCRPRRG 544          
BLAST of Fzd-1/2/7 vs. Ensembl Human
Match: FZD10 (frizzled class receptor 10 [Source:HGNC Symbol;Acc:HGNC:4039])

HSP 1 Score: 396.356 bits (1017), Expect = 1.709e-128
Identity = 224/526 (42.59%), Postives = 314/526 (59.70%), Query Frame = 3
Query:  117 NCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCT-IMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESAPNVSLSCP---KSLQIPVSYDFKIRLSQNSVIQDCG-------------------------IPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLN-DKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWK 1604
             C+ I++P C+ + Y MT  PN M H  Q EAA++++E+ PL+   CHG L+ FLCSLY P+CT  +   +P CR +C Q + +C PI+++F FKWP S+ C   P  N    D       APN     P     L  P+    +   +Q   ++D G                          P    Y++  + ++FA VW+A+W+ +C  S+ FTVLTFLID  RF+YPERPIIFLS CY V  + Y+   F   + +AC       D       ++ +G +   C ++F++LY+F MAS++WWVVLT+TW+LAA   W HE+I  NS YFH AAWAIPA KTI IL + +V GD LTGVC+ G  D + L GF++ PL  YL+IGT F+++GFV++F IR ++KTGG  TDKLEKL+ RIG+FSVLY VPA  VIACYF+E +N    M  W ++    +A++K  CK  +  K +    + L+ +  P  E+FM+K  M L+VGITSG+WIW+ KTL SW+
Sbjct:   33 KCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKN----DPNYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKFHHVEKSASCAPLCTPGVDVYWSRED-KRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIAC-------DRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLN----MDYWKIL----AAQHK--CKMNNQTKTL----DCLMAASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQ 532          
BLAST of Fzd-1/2/7 vs. Ensembl Celegans
Match: mom-5 (pep chromosome:WBcel235:I:9965580:9969413:1 gene:WBGene00003397.1 transcript:T23D8.1a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mom-5)

HSP 1 Score: 328.176 bits (840), Expect = 6.773e-103
Identity = 189/556 (33.99%), Postives = 289/556 (51.98%), Query Frame = 3
Query:   78 NNIRAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKES---------------APNVSLS---CPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRY----YFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTP-KIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTD----KLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHK-----------PINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGR 1631
             +I ++N       CE I +P C+ L Y  T+FPN + H+TQ EA   I ++ PL+++KC   ++LFLC++Y PVCT+++K + PCR LCL  K  CE ++KKF F+WP  + C+ +P  +LC+  N +E  +               A  V LS   CP  +       F + L     + +C + C          +  +R+  R+W A WS  C   +LFT++TFL+D+ RF YP RPI++L+ CYL +   Y+ G    D  AC        + G TP  +V QG +   C  L ++ YFF M+S  WW+VL + W+LAA   W  ESI   S YFH   W +PA  ++ +L  + VDGD  TG+C  G  +PS L  F   P+ + L +G   L+ G  SM  IR+ IK   +  +    KLEKL+ RIG F+++Y +P  +  A  +++++N+  W++ W              C ++ D +           P++P   A      PE  +F++KY+  L+VGIT  IW+ S KTL S+   +  L  R
Sbjct:   23 TSISSMNGFSTTRKCEHITIPMCKNLDYNQTVFPNLLGHTTQSEAGPAIAQFNPLIKVKCSEDIRLFLCTVYAPVCTVLEKPIQPCRELCLSAKNGCESLMKKFGFQWPDQLDCNKFPVTDLCVGKNSSESSNSKKSSNDVTFGVSTIANEVVLSPKKCPHHMHTTSGSHFSLPLLSGR-LPECSLTCEADNQVPMMFDGRVRRILRIWTAAWSVACFVCSLFTLVTFLVDLSRFAYPVRPILYLAFCYLAISTVYMIGVVGEDGFACG-------TYGSTPTTLVTQGGENVGCSALAVVHYFFFMSSCAWWLVLCLAWFLAANLKWGAESIAALSPYFHAMCWGVPAVLSVTVLVTNSVDGDVFTGICSVGNLNPSALVYFFFTPIVVSLALGAVLLVCGIWSMIRIRSYIKLQHADVERNISKLEKLMLRIGAFAIMYSLPTAMNAAIMWYQAVNMPAWLEGW----------LHHRCVRLQDRELFGFTYPVDDCPMDPKVAA------PEIIVFLLKYVSQLVVGITCAIWVVSSKTLSSYHKAYLALSSR 554          
BLAST of Fzd-1/2/7 vs. Ensembl Celegans
Match: mom-5 (pep chromosome:WBcel235:I:9965580:9970037:1 gene:WBGene00003397.1 transcript:T23D8.1b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mom-5)

HSP 1 Score: 327.791 bits (839), Expect = 1.059e-102
Identity = 189/558 (33.87%), Postives = 289/558 (51.79%), Query Frame = 3
Query:   78 NNIRAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCI---------------RDNQTEKES--APNVSLS---CPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRY----YFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTP-KIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTD----KLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHK-----------PINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGR 1631
             +I ++N       CE I +P C+ L Y  T+FPN + H+TQ EA   I ++ PL+++KC   ++LFLC++Y PVCT+++K + PCR LCL  K  CE ++KKF F+WP  + C+ +P  +LC+                ++ T   S  A  V LS   CP  +       F + L     + +C + C          +  +R+  R+W A WS  C   +LFT++TFL+D+ RF YP RPI++L+ CYL +   Y+ G    D  AC        + G TP  +V QG +   C  L ++ YFF M+S  WW+VL + W+LAA   W  ESI   S YFH   W +PA  ++ +L  + VDGD  TG+C  G  +PS L  F   P+ + L +G   L+ G  SM  IR+ IK   +  +    KLEKL+ RIG F+++Y +P  +  A  +++++N+  W++ W              C ++ D +           P++P   A      PE  +F++KY+  L+VGIT  IW+ S KTL S+   +  L  R
Sbjct:   23 TSISSMNGFSTTRKCEHITIPMCKNLDYNQTVFPNLLGHTTQSEAGPAIAQFNPLIKVKCSEDIRLFLCTVYAPVCTVLEKPIQPCRELCLSAKNGCESLMKKFGFQWPDQLDCNKFPVTDLCVGKNSSESSNSKNYRSSNDVTFGVSTIANEVVLSPKKCPHHMHTTSGSHFSLPLLSGR-LPECSLTCEADNQVPMMFDGRVRRILRIWTAAWSVACFVCSLFTLVTFLVDLSRFAYPVRPILYLAFCYLAISTVYMIGVVGEDGFACG-------TYGSTPTTLVTQGGENVGCSALAVVHYFFFMSSCAWWLVLCLAWFLAANLKWGAESIAALSPYFHAMCWGVPAVLSVTVLVTNSVDGDVFTGICSVGNLNPSALVYFFFTPIVVSLALGAVLLVCGIWSMIRIRSYIKLQHADVERNISKLEKLMLRIGAFAIMYSLPTAMNAAIMWYQAVNMPAWLEGW----------LHHRCVRLQDRELFGFTYPVDDCPMDPKVAA------PEIIVFLLKYVSQLVVGITCAIWVVSSKTLSSYHKAYLALSSR 556          
BLAST of Fzd-1/2/7 vs. Ensembl Celegans
Match: cfz-2 (Frizzled-2 [Source:UniProtKB/Swiss-Prot;Acc:G5ECQ2])

HSP 1 Score: 282.722 bits (722), Expect = 1.384e-85
Identity = 186/618 (30.10%), Postives = 306/618 (49.51%), Query Frame = 3
Query:   45 FLIVSFVFLFINNIRAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTI-MKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPE-------NNLCIRDNQTE----------------------KESAPNVSLS--------CPKSLQIPVSYDFKIRLSQNSVI---QDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFL-NDKVACAGPFTNKDSTGKTPKIVVQGTKFES---CIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGG---SKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFF-----SRLCGRLNPGDP-WTRSDWLEK---NNGYYQRHFVGPTANKM 1727
             L +S +FL + +  A+     +  CE+I +P C+G+ Y MT FPN   H  Q+EA LE++++ PL+ + C   L+ FLC++Y P+C     K + PC  LC++ + +C PI+ K+ F+WP+++SC+  P+        N+C     T                           P V +S         P   Q   +  F+   S+ S +    +C   C+     E +       W+A WS  C     FT LTFLI+  RFQYPERPI  L+ C L+V + ++  +F+ ++++AC       DS      + ++G    S   C ++F+L YFF MA+++WWV+L++TW L+A   W+ E+I   S +FH   W +PA +T+ ++  + +DGDP+TG+C+ G +D    R F++ PL +Y ++G  FL+ GF +++ IR  ++          K+ +L+++IGIFS+LY +P++++I   F+E  +   W Q      +C  +  +              G ++LI S        +IK     I+G TSG W+ S KTL SWK        SR   +  P D  + +SD       N      H  G   +K+
Sbjct:    2 LLRISVLFLLLGSCGALFG--KRQKCEQITIPLCKGIGYNMTSFPNSYGHEKQEEAGLEVHQFYPLVEVGCFQHLKFFLCTMYTPICQENYDKPILPCMELCVEARSKCSPIMAKYGFRWPETLSCEALPKMSDQMSTGNICAAPPDTPKKQHKGHHHKNQNQNQNQNHNYSPDGPEVGISKIDNEVIAGPSECQCTCNQPFQFVASEKSKVGNVTNCAYSCHSPALAESH--SLVSNWMAFWSITCCVLASFTFLTFLIETDRFQYPERPIFMLAFCQLMVAVGFMIRYFVGHEEIAC-------DS------MRIKGADDNSGSLCFVVFLLTYFFGMAASVWWVILSLTWVLSAASKWSPEAISSFSFHFHVVGWCLPAIQTVLVIVFNAIDGDPITGICYVGNTDLQFQRIFVLFPLLVYFIVGVLFLVIGFCNLWSIRNEVQKQHPSLESAHKITQLMSKIGIFSLLYTIPSLLIICVLFYEQNHRSLWEQS----QLCSCSPKQ------------TIGDSSLIIS--------LIKTCCMCILGWTSGFWVCSTKTLSSWKNAICCLGSSRSLPKYQPADILYAKSDMSSSQFYNTSLRHNHLYGGIPDKL 578          
BLAST of Fzd-1/2/7 vs. Ensembl Celegans
Match: lin-17 (Transmembrane receptor LIN-17 [Source:UniProtKB/TrEMBL;Acc:G5EDV1])

HSP 1 Score: 256.144 bits (653), Expect = 8.403e-76
Identity = 167/544 (30.70%), Postives = 263/544 (48.35%), Query Frame = 3
Query:   90 AVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTI-MKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPEN-NLCIRDNQTEKE---SAPNVSL-----------SCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFES-CIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYF-FSRLCGRL---NPGDPWTR 1658
            ++ D   +  C  I +  C+ L Y  T FPN +LH+ Q         + PLM+ KCH  +  F+CS++ P+C I M +A+  C+S+C Q+K +C  IL++F   WP+ ++C  +P+   LC++  + E     SAP +              CP  L     +D K           C   C        + ++  R W   ++    G  LF+ LTF ID KRF++PER + +LS C  +  L Y+   F++       P  +  + G     +  GT   S C+  F+L YFFS A+A+WW++ + T YL+    W  E I   S Y HF AW + +  TI +L  +KVD   LT +C  G  +   L  F+I P  I ++IGT F++ GF SM   R   +T G+ T KLEKL+ ++G F  L+++P V+ + C  ++ M L +W +         + + K +    H   P             P+ E++M   + SL  G +  +W+ S KT+ +WK F F  +C      NP +P TR
Sbjct:   18 SIFDQAVKGKCIPIDIELCKDLPYNYTYFPNTILHNDQHTLQTHTEHFKPLMKTKCHPHIHFFICSVFAPMCPIGMPQAVTSCKSVCEQVKADCFSILEEFGIGWPEPLNCAQFPDPPELCMKPTEDEITGGFSAPRLPTKGSSSSSSKPTGCPSDLVDVDPHDPK---------SHCAFACQSNVMFSTDNKRMVRSWSIWFAAANAGVALFSFLTFAIDRKRFRFPERCVFYLSLCIFISSLPYLTPLFID------APIRSCHALGNGRSYLSIGTFDNSYCLASFLLNYFFSTAAALWWLMFSFTLYLSGGRKWVPEGIEACSSYVHFVAWGLSSLATIIVLIFNKVDASELTALCSVGNLNSIALLWFVIVPRTICIVIGTCFIVGGFASMCRERISFRTRGTDTSKLEKLMVKMGFFCALFILPNVIELVCQCYKFMILTQWTR--------MTIDCKQQSGACHRPTP-------------PQAEIYMTAVISSLATGFSCLMWVLSAKTVHAWKNFIFCGMCSSAPVKNPIEPSTR 525          
BLAST of Fzd-1/2/7 vs. Ensembl Celegans
Match: lin-17 (Transmembrane receptor LIN-17 [Source:UniProtKB/TrEMBL;Acc:G5EDV1])

HSP 1 Score: 256.144 bits (653), Expect = 8.403e-76
Identity = 167/544 (30.70%), Postives = 263/544 (48.35%), Query Frame = 3
Query:   90 AVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTI-MKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPEN-NLCIRDNQTEKE---SAPNVSL-----------SCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFES-CIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYF-FSRLCGRL---NPGDPWTR 1658
            ++ D   +  C  I +  C+ L Y  T FPN +LH+ Q         + PLM+ KCH  +  F+CS++ P+C I M +A+  C+S+C Q+K +C  IL++F   WP+ ++C  +P+   LC++  + E     SAP +              CP  L     +D K           C   C        + ++  R W   ++    G  LF+ LTF ID KRF++PER + +LS C  +  L Y+   F++       P  +  + G     +  GT   S C+  F+L YFFS A+A+WW++ + T YL+    W  E I   S Y HF AW + +  TI +L  +KVD   LT +C  G  +   L  F+I P  I ++IGT F++ GF SM   R   +T G+ T KLEKL+ ++G F  L+++P V+ + C  ++ M L +W +         + + K +    H   P             P+ E++M   + SL  G +  +W+ S KT+ +WK F F  +C      NP +P TR
Sbjct:   18 SIFDQAVKGKCIPIDIELCKDLPYNYTYFPNTILHNDQHTLQTHTEHFKPLMKTKCHPHIHFFICSVFAPMCPIGMPQAVTSCKSVCEQVKADCFSILEEFGIGWPEPLNCAQFPDPPELCMKPTEDEITGGFSAPRLPTKGSSSSSSKPTGCPSDLVDVDPHDPK---------SHCAFACQSNVMFSTDNKRMVRSWSIWFAAANAGVALFSFLTFAIDRKRFRFPERCVFYLSLCIFISSLPYLTPLFID------APIRSCHALGNGRSYLSIGTFDNSYCLASFLLNYFFSTAAALWWLMFSFTLYLSGGRKWVPEGIEACSSYVHFVAWGLSSLATIIVLIFNKVDASELTALCSVGNLNSIALLWFVIVPRTICIVIGTCFIVGGFASMCRERISFRTRGTDTSKLEKLMVKMGFFCALFILPNVIELVCQCYKFMILTQWTR--------MTIDCKQQSGACHRPTP-------------PQAEIYMTAVISSLATGFSCLMWVLSAKTVHAWKNFIFCGMCSSAPVKNPIEPSTR 525          
BLAST of Fzd-1/2/7 vs. Ensembl Fly
Match: fz (gene:FBgn0001085 transcript:FBtr0075743)

HSP 1 Score: 441.425 bits (1134), Expect = 3.388e-146
Identity = 236/546 (43.22%), Postives = 333/546 (60.99%), Query Frame = 3
Query:  117 NCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPEN---NLCIRDN-----------------------QTEKESAP-NVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKI--VVQGTK-FESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLNPGDPWTRSD 1664
             CE I +  C+ + Y MTI PN + H+ Q+EA LE++++ PL++I C   LQLFLCSLY PVCTI+++ +PPCRSLC +  + CE ++K + F WP+++ C  +P +   +LC+ +N                       QT  ES   N+   CP  L+ P+   +++++     + DCG PC+  +F E   R   R WV  W+ +CV S LFTVLTFLID  RF+YPER I+FL+ CYLVVG  YVAG    D V+C  PF      G+   +  + QG +   SC +LFM LYF  MA+  WW  L   W+LAA   W HE+I   S  FH  AWA+PA +TI +LAL+KV+GD L+GVCF G  D  +L  FLI PLCIYL IG  FL+AGF+S+F IRT++KT G +TDKLE+L+ RIG FS L+++PAV ++ C F+E  N  +WM +W+  DIC+   +   C       P +P         +P F++FM+KYL S++VG+TS +W++S KT++SW+ F  RL G+    +P TR+ 
Sbjct:   52 RCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLC-ESARVCEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTAATPTRSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKD-LHDCGAPCHAMFFPERE-RTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAGDSVSCREPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHR-DICKP--FSIPCPA--ARAPGSP-------EARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERLQGK----EPRTRAQ 578          
BLAST of Fzd-1/2/7 vs. Ensembl Fly
Match: fz (gene:FBgn0001085 transcript:FBtr0330102)

HSP 1 Score: 441.81 bits (1135), Expect = 6.470e-146
Identity = 236/546 (43.22%), Postives = 333/546 (60.99%), Query Frame = 3
Query:  117 NCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPEN---NLCIRDN-----------------------QTEKESAP-NVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKI--VVQGTK-FESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLNPGDPWTRSD 1664
             CE I +  C+ + Y MTI PN + H+ Q+EA LE++++ PL++I C   LQLFLCSLY PVCTI+++ +PPCRSLC +  + CE ++K + F WP+++ C  +P +   +LC+ +N                       QT  ES   N+   CP  L+ P+   +++++     + DCG PC+  +F E   R   R WV  W+ +CV S LFTVLTFLID  RF+YPER I+FL+ CYLVVG  YVAG    D V+C  PF      G+   +  + QG +   SC +LFM LYF  MA+  WW  L   W+LAA   W HE+I   S  FH  AWA+PA +TI +LAL+KV+GD L+GVCF G  D  +L  FLI PLCIYL IG  FL+AGF+S+F IRT++KT G +TDKLE+L+ RIG FS L+++PAV ++ C F+E  N  +WM +W+  DIC+   +   C       P +P         +P F++FM+KYL S++VG+TS +W++S KT++SW+ F  RL G+    +P TR+ 
Sbjct:   52 RCEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLC-ESARVCEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTAATPTRSVAKVTTRKHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKD-LHDCGAPCHAMFFPERE-RTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAGDSVSCREPFPPPVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHR-DICKP--FSIPCPA--ARAPGSP-------EARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERLQGK----EPRTRAQ 578          
BLAST of Fzd-1/2/7 vs. Ensembl Fly
Match: fz2 (gene:FBgn0016797 transcript:FBtr0112890)

HSP 1 Score: 323.168 bits (827), Expect = 1.898e-99
Identity = 183/423 (43.26%), Postives = 258/423 (60.99%), Query Frame = 3
Query:  432 ENNLCIRDNQTEKESAPNVSLSCPKSL-------------QIPVSYD-----FKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFL-NDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKT-----GGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCG 1628
             N+   ++ Q EK S    S SC   L             Q+P+ +        + + + + + +CGIPC   +F+  + + FA +W+ALWS +C  STL T+ TF+ID +RF+YPERPI+FLSACY +V + Y++  FL N+++AC G    + STG             SC ++F+L YFF MAS+IWWV+L+ TW+LAA   W +E+I ++SQYFH AAW IP  +++ +L LS VDGDP+ G+C+ G  +P  L+ F++APL +YL+IGT FL+AGFVS+F IR++IK       G K DKLEKL+ RIGIFSVLY VPA +VI CY +E+     W++       C  A+ K             PG       +KP + + M+KY M+L VGITSG+WIWSGKTL SW+ F+ RL G
Sbjct:  235 RNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSN-DEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGLLLRESSTGP-----------HSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKAL----ACPCAQVK------------GPG-------KKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLG 622          

HSP 2 Score: 119.783 bits (299), Expect = 1.291e-27
Identity = 53/118 (44.92%), Postives = 78/118 (66.10%), Query Frame = 3
Query:  117 NCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVC-TIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP----ENNLCIRD 455
             CE+I +P C+G+ Y MT FPN M H TQDEA LE++++ PL+ IKC   L+ FLCS+Y P+C     K LP CRS+C + +  C PI++++ F+WP+ M+C+  P     +NLC+  
Sbjct:   63 RCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQ 180          
BLAST of Fzd-1/2/7 vs. Ensembl Fly
Match: fz2 (gene:FBgn0016797 transcript:FBtr0075029)

HSP 1 Score: 323.168 bits (827), Expect = 1.898e-99
Identity = 183/423 (43.26%), Postives = 258/423 (60.99%), Query Frame = 3
Query:  432 ENNLCIRDNQTEKESAPNVSLSCPKSL-------------QIPVSYD-----FKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFL-NDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKT-----GGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCG 1628
             N+   ++ Q EK S    S SC   L             Q+P+ +        + + + + + +CGIPC   +F+  + + FA +W+ALWS +C  STL T+ TF+ID +RF+YPERPI+FLSACY +V + Y++  FL N+++AC G    + STG             SC ++F+L YFF MAS+IWWV+L+ TW+LAA   W +E+I ++SQYFH AAW IP  +++ +L LS VDGDP+ G+C+ G  +P  L+ F++APL +YL+IGT FL+AGFVS+F IR++IK       G K DKLEKL+ RIGIFSVLY VPA +VI CY +E+     W++       C  A+ K             PG       +KP + + M+KY M+L VGITSG+WIWSGKTL SW+ F+ RL G
Sbjct:  235 RNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSN-DEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGLLLRESSTGP-----------HSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKAL----ACPCAQVK------------GPG-------KKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLG 622          

HSP 2 Score: 119.783 bits (299), Expect = 1.291e-27
Identity = 53/118 (44.92%), Postives = 78/118 (66.10%), Query Frame = 3
Query:  117 NCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVC-TIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP----ENNLCIRD 455
             CE+I +P C+G+ Y MT FPN M H TQDEA LE++++ PL+ IKC   L+ FLCS+Y P+C     K LP CRS+C + +  C PI++++ F+WP+ M+C+  P     +NLC+  
Sbjct:   63 RCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQ 180          
BLAST of Fzd-1/2/7 vs. Ensembl Fly
Match: fz2 (gene:FBgn0016797 transcript:FBtr0332735)

HSP 1 Score: 323.168 bits (827), Expect = 1.898e-99
Identity = 183/423 (43.26%), Postives = 258/423 (60.99%), Query Frame = 3
Query:  432 ENNLCIRDNQTEKESAPNVSLSCPKSL-------------QIPVSYD-----FKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFL-NDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKT-----GGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCG 1628
             N+   ++ Q EK S    S SC   L             Q+P+ +        + + + + + +CGIPC   +F+  + + FA +W+ALWS +C  STL T+ TF+ID +RF+YPERPI+FLSACY +V + Y++  FL N+++AC G    + STG             SC ++F+L YFF MAS+IWWV+L+ TW+LAA   W +E+I ++SQYFH AAW IP  +++ +L LS VDGDP+ G+C+ G  +P  L+ F++APL +YL+IGT FL+AGFVS+F IR++IK       G K DKLEKL+ RIGIFSVLY VPA +VI CY +E+     W++       C  A+ K             PG       +KP + + M+KY M+L VGITSG+WIWSGKTL SW+ F+ RL G
Sbjct:  235 RNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGPFFSN-DEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGLLLRESSTGP-----------HSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKAL----ACPCAQVK------------GPG-------KKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLG 622          

HSP 2 Score: 119.783 bits (299), Expect = 1.291e-27
Identity = 53/118 (44.92%), Postives = 78/118 (66.10%), Query Frame = 3
Query:  117 NCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVC-TIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP----ENNLCIRD 455
             CE+I +P C+G+ Y MT FPN M H TQDEA LE++++ PL+ IKC   L+ FLCS+Y P+C     K LP CRS+C + +  C PI++++ F+WP+ M+C+  P     +NLC+  
Sbjct:   63 RCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQ 180          
BLAST of Fzd-1/2/7 vs. Ensembl Zebrafish
Match: fzd1 (frizzled class receptor 1 [Source:ZFIN;Acc:ZDB-GENE-990415-219])

HSP 1 Score: 505.368 bits (1300), Expect = 1.541e-171
Identity = 262/524 (50.00%), Postives = 347/524 (66.22%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENN--LCIRDN---------------QTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCN------RYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++ALPPCRSLC + ++ CE ++ KF F+WP+S++C+ +P +   LC+  N               Q   E +      CP SL++P   +++     N     CG PC         YF+E + +KFAR+W+ +WS +C  STLFTVLT+L+DMKRF YPERPIIFLS CY +V + Y+AGF L DKV C   F N+  T      VVQGTK E C ILFM+LYFFSM+S+IWWV+L +TW+LAA   W HE+I  NSQYFH AAWA+PA KTI ILA+ +VDGD L+GVCF G++    LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIGIFSVLY VPA +VIACYF+E      W Q W     C++  Y   C     H P             P+F +FMIKYLM+LIVGITSG WIWSGKTL SW+ F++RL
Sbjct:   33 CQPISIPLCTDIAYNETIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPDLKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPESLACESFPVHGGELCVGQNTTGPSPPVSPTPDATQAPPEPSQRGRFQCPPSLRVPPYLNYRFMGEDN-----CGAPCEPRKLHGMMYFSE-DEQKFARIWIGIWSVLCCASTLFTVLTYLVDMKRFSYPERPIIFLSGCYTMVSIAYIAGFLLEDKVVCNEQFENEFRT------VVQGTKKEGCTILFMMLYFFSMSSSIWWVILALTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILAVGQVDGDVLSGVCFVGINSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFRAHWEQTWS-AHSCKT--YAVPCPA---HNP----------QMNPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRL 528          
BLAST of Fzd-1/2/7 vs. Ensembl Zebrafish
Match: fzd7a (frizzled class receptor 7a [Source:ZFIN;Acc:ZDB-GENE-990415-223])

HSP 1 Score: 498.434 bits (1282), Expect = 1.385e-168
Identity = 256/560 (45.71%), Postives = 353/560 (63.04%), Query Frame = 3
Query:   60 FVFLFINNIRAVNDPYNQPN---------CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP---ENNLCIRDNQTEKESA---------------------PNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCN------RYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            F+ LF   ++  +  Y+            C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++A+PPCRSLC + ++ CE ++ KF F+WP+ + C+ +P      +C+  N ++  S                      PN   +CP  L++P    +     +     DCG PC         YF E  + KF R+WV +WS +C  STLFTVLT+L+DM+RF+YPERPIIFLS CY +V + Y AGFFL DKV C   F++        K V QGTK E C ILFM+LYFF MAS+IWWV+L++TW+L+A   W HE+I  NSQYFH AAWA+PA KTI ILA+ +VDGD LTGVC+ G+ +  +LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIG+FSVLY VPA +VIACYF+E     +W + W++            CK+     P+N           P+F +FMIKYLM++IVGITSG WIWSGKTL SW+ F+ RL
Sbjct:   16 FLLLFTVALQTTSGQYHGEKGISIPEHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSMDLKFFLCSMYAPVCTVLEQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDAGSPTSNPTPYVPELITLQPNLVVRPNQQFTCPLQLKVPTYLKYHFMGEK-----DCGAPCEPTRPNGLMYFREEEV-KFGRLWVGIWSILCCVSTLFTVLTYLVDMRRFRYPERPIIFLSGCYFMVAVAYAAGFFLEDKVVCIDKFSDDGY-----KTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLSAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDMLTGVCYVGIYNVDSLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFREQWEKTWHM----------QTCKRFAVPCPVNNFA-----PMSPDFTVFMIKYLMTMIVGITSGFWIWSGKTLQSWRRFYKRL 549          
BLAST of Fzd-1/2/7 vs. Ensembl Zebrafish
Match: fzd7a (frizzled class receptor 7a [Source:ZFIN;Acc:ZDB-GENE-990415-223])

HSP 1 Score: 498.434 bits (1282), Expect = 1.385e-168
Identity = 256/560 (45.71%), Postives = 353/560 (63.04%), Query Frame = 3
Query:   60 FVFLFINNIRAVNDPYNQPN---------CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP---ENNLCIRDNQTEKESA---------------------PNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCN------RYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            F+ LF   ++  +  Y+            C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++A+PPCRSLC + ++ CE ++ KF F+WP+ + C+ +P      +C+  N ++  S                      PN   +CP  L++P    +     +     DCG PC         YF E  + KF R+WV +WS +C  STLFTVLT+L+DM+RF+YPERPIIFLS CY +V + Y AGFFL DKV C   F++        K V QGTK E C ILFM+LYFF MAS+IWWV+L++TW+L+A   W HE+I  NSQYFH AAWA+PA KTI ILA+ +VDGD LTGVC+ G+ +  +LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIG+FSVLY VPA +VIACYF+E     +W + W++            CK+     P+N           P+F +FMIKYLM++IVGITSG WIWSGKTL SW+ F+ RL
Sbjct:   16 FLLLFTVALQTTSGQYHGEKGISIPEHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSMDLKFFLCSMYAPVCTVLEQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDAGSPTSNPTPYVPELITLQPNLVVRPNQQFTCPLQLKVPTYLKYHFMGEK-----DCGAPCEPTRPNGLMYFREEEV-KFGRLWVGIWSILCCVSTLFTVLTYLVDMRRFRYPERPIIFLSGCYFMVAVAYAAGFFLEDKVVCIDKFSDDGY-----KTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLSAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDMLTGVCYVGIYNVDSLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFREQWEKTWHM----------QTCKRFAVPCPVNNFA-----PMSPDFTVFMIKYLMTMIVGITSGFWIWSGKTLQSWRRFYKRL 549          
BLAST of Fzd-1/2/7 vs. Ensembl Zebrafish
Match: fzd2 (frizzled class receptor 2 [Source:ZFIN;Acc:ZDB-GENE-990415-224])

HSP 1 Score: 498.049 bits (1281), Expect = 1.532e-168
Identity = 251/527 (47.63%), Postives = 350/527 (66.41%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP---ENNLCIRDNQT-----------------EKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNR------YYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            C+ I +P C  + Y  TI PN + H  QD+A LE++++ PL++++C   L+ FLCS+Y PVCT+++KA+PPCRS+C + K+ CE ++ KF F+WP+++ C+ +P   + ++C+  N +                 +  S P+    CP +L++P    +K  L +     DCG PC        Y F      +FAR+W+ +WS +C  STLFTV T+++DM+RF+YPERPIIFLS CY +V + Y+AG+FL DKV C     N+     + K +VQGTK E C ILFM+LYFFSMAS+IWWV+L++TW+LAA   W HE+I  NSQYFH AAWA+PA KTI ILA+ ++DGD L+GVCF GL++   LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLE+L+ RIG+FSVLY VPA +VIAC+F+E     +W + W  ++          CK +    P+ P  +       P+F +FMIKYLM+LIVGITSG WIWSGKTL SW+ F+ RL
Sbjct:   39 CQPITIPLCTDIAYNQTIMPNLVGHYNQDDAGLEVHQFYPLVKVQCSPELKFFLCSMYAPVCTVLEKAIPPCRSICERAKQGCEVLMNKFGFQWPEALRCEHFPVLGDGHICVGQNDSMATVSPVHMPIPGTPSVQLYSTPDKPFRCPSTLKVPAYLSYKF-LGE----PDCGAPCESSRTHRAYMFFTDQEIEFARIWILIWSSLCCASTLFTVTTYIVDMQRFKYPERPIIFLSGCYTMVSIAYIAGYFLGDKVVC-----NESFFPDSYKTIVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTISILAMGQIDGDVLSGVCFVGLNNSDALRGFILAPLFLYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACFFYEQAFRQQWEKSWISMN----------CKSLAIPCPMQPAPH-----MTPDFTVFMIKYLMTLIVGITSGFWIWSGKTLHSWQKFYVRL 540          
BLAST of Fzd-1/2/7 vs. Ensembl Zebrafish
Match: fzd7b (frizzled class receptor 7b [Source:ZFIN;Acc:ZDB-GENE-990415-229])

HSP 1 Score: 490.73 bits (1262), Expect = 1.426e-165
Identity = 251/530 (47.36%), Postives = 343/530 (64.72%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP---ENNLCIRDNQTEKE--------------------SAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNR------YYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++A+PPCR+LC + ++ CE ++ KF F+WP+ + C+ +P      +C+  N+++ +                       N + +CP  L +P   ++    ++N     CG PC         YF E  +R F R+WV +WS +C  STLFTVLT+L+DM+RF YPERPIIFLS CY +V + Y AGF L DKV C   F  +D   KT   V QGTK E C ILFM+LYFF MAS+IWWV+L++TW+L+A   W HE+I  NSQYFH AAWA+PA KTI ILAL +VDGD LTGVC+ G+ +   LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIG+FSVLY VPA +VIACYF+E     +W + W++            CK+        P  N       P+F +FMIKYLM++IVGITSG WIWSGKTL SW+ F+ RL
Sbjct:   45 CQPISIPLCTDIQYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSQDLKFFLCSMYAPVCTVLEQAIPPCRTLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNKSDPDVPTTNPTPYIPEPFSPRIHTPRQNQAFTCPLQLTVPSYLNYHFLGAKN-----CGAPCEHKQPYGLMYFKEEEVR-FGRLWVGIWSILCCVSTLFTVLTYLVDMRRFHYPERPIIFLSGCYFMVAVAYAAGFLLEDKVVCIDKF--RDDAFKT---VAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLSAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILALGQVDGDLLTGVCYVGIYNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFREQWEKTWHM----------QTCKRF-----AVPCPNNNFAPMTPDFTVFMIKYLMTMIVGITSGFWIWSGKTLQSWRRFYKRL 548          
BLAST of Fzd-1/2/7 vs. Ensembl Xenopus
Match: ntrk1 (neurotrophic receptor tyrosine kinase 1 [Source:Xenbase;Acc:XB-GENE-923001])

HSP 1 Score: 486.493 bits (1251), Expect = 7.319e-164
Identity = 246/529 (46.50%), Postives = 346/529 (65.41%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPEN---NLCIRDNQTEKESAPNVSLS--------------------CPKSLQIPVSYDFKIRLSQNSVIQDCGIPC-----NRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++A+PPCRS+C + +  CE ++ KF F+WP+ + C+ +P +    +C+  N +E      ++ S                    CP+ L++P   +++  L +    +DC  PC     + + F   +  +FARVW+ +WS +C  ST FTV T+L+DM+RF+YPERPIIFLS CY +V + Y+AGF L DKV C     N++ +    K VVQGTK E C ILFM+LYFFSMAS+IWWV+L++TW+LAA   W HE+I  NSQYFH AAWA+PA KTI ILA+ ++DGD L+GVCF GL++   LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLE+L+ RIG+FSVLY VPA +VIACYF+E      W + W              CK +    P+            P+F ++MIKYLM+LIVGITSG WIWSGKTL SW+ F++RL
Sbjct:   40 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSSELRFFLCSMYAPVCTVLEQAIPPCRSICERARHGCEALMNKFGFQWPERLRCENFPRHGAEQICVGQNHSEDGGPTLLTTSPPHHGTPGPPIYATLDHPFHCPRVLKVPSYLNYRF-LGE----KDCAAPCEPSKNDGFMFFSQDEIRFARVWILIWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLGDKVVC-----NENFSEDGYKTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNNIDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSW----------VSQNCKSLAIPCPLQYTPR-----MTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRL 543          
BLAST of Fzd-1/2/7 vs. Ensembl Xenopus
Match: bdh2 (3-hydroxybutyrate dehydrogenase 2 [Source:Xenbase;Acc:XB-GENE-985755])

HSP 1 Score: 484.182 bits (1245), Expect = 4.243e-163
Identity = 246/529 (46.50%), Postives = 349/529 (65.97%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP---ENNLCIRDNQTEKESA-------------------PNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPC------NRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++A+PPCRSLC + ++ CE ++ KF F+WP+ + C+ +P      +C+  N ++   +                   PN   +CP+ L++P    ++  L +    +DCG PC         YF E  +R FAR+WV +W+ +C  STLFTVLT+L+DM+RF YPERPIIFLS CY +V + Y AGF L ++  C   F+ +DS     + V QGTK E C ILFM+LYFF MAS+IWWV+L++TW+LAA   W HE+I  NSQYFH AAWA+PA KTI ILA+ +VDGD L+GVC+ G++   +LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIG+FSV+Y VPA +V+ACYF+E      W + W L+  C+   +   C   ++  P++           P+F +FMIKYLM++IVGITS  WIWSGKTL SW+ F+ RL
Sbjct:   36 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDNSPSGPTARPTPYLPDSITFHPHPNRDFTCPRQLKVPPYLGYRF-LGE----KDCGAPCEPGKANGLMYFKEEEVR-FARLWVGIWAILCGISTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAYTAGFLLEERGVCVERFS-EDSY----RTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDILSGVCYVGINSVDSLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVMYTVPATIVLACYFYEQAFRDTWEKTW-LVQTCKG--FAVPCPN-YNFAPMS-----------PDFTVFMIKYLMTMIVGITSSFWIWSGKTLQSWRRFYHRL 538          
BLAST of Fzd-1/2/7 vs. Ensembl Xenopus
Match: zdhhc9 (zinc finger DHHC-type containing 9 [Source:Xenbase;Acc:XB-GENE-1016830])

HSP 1 Score: 432.95 bits (1112), Expect = 6.191e-143
Identity = 241/550 (43.82%), Postives = 329/550 (59.82%), Query Frame = 3
Query:   60 FVFLFINNIRAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCT-IMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPE----NNLCIRDNQTE-----------KESAPNVSLSCPKSLQIPV------SYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFL-NDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLNP 1640
            FV L ++    V        C++I VP C+G+ Y  T  PN   H TQDEA +E++++ PL+ I+C   L+ FLCS+Y P+C    +K LPPCRS+C + K  C P+++K+ F WP+ M+CD  PE    + LC+  N TE           K   P+         + P       S+    R+    V  +C +PC + YF + + + FA  W+ LWS +C  ST  TV TFLIDM+RF+YPERPIIFLSACYL V + Y+    + ++ VAC     + ++TG  P +         C ++F+L+YFF MAS+IWWV+LT TW+LAA   W +E+I   SQYFH AAW IP+ K+I +LALS VDGDP+ G+CF G  +   LRGF++APL +YL  GT FL+AGFVS+F IR++IK GG+KTDKLEKL+ RIGIFSVLY VPA +V+ACY +E                     Y++  +K H+     PG        +P++ +FM+KY M L+VGITSG+WIWSGKTL SWK F  R C    P
Sbjct:   13 FVILLLDYFAPVRPASKAIVCQEITVPMCKGIGYNHTYMPNQFNHDTQDEAGMEVHQFWPLVVIQCSLDLKFFLCSMYTPICLPDYRKPLPPCRSVCERAKAGCSPLMRKYGFAWPERMNCDRLPEHGDPDTLCMDYNWTETTTTPPPTHPPKVKTPSSDCDGVCKCREPFLSITRESHPLYNRIKTGQV-PNCAMPCFQPYFTQ-DEKTFATFWIGLWSILCFISTFTTVATFLIDMERFRYPERPIIFLSACYLFVSIGYIVRLIVGHENVACNKDHIHYETTG--PAL---------CTVVFLLIYFFGMASSIWWVILTFTWFLAAGMKWGNEAIASYSQYFHMAAWLIPSVKSIAVLALSSVDGDPVAGICFVGNQNLDNLRGFVLAPLVVYLFTGTMFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFSVLYTVPATIVVACYIYEQ-------------------HYREHWEKAHNCS--CPGDKK---RYRPDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWKRFTGRCCRNSKP 525          
BLAST of Fzd-1/2/7 vs. Ensembl Xenopus
Match: fzd8 (frizzled class receptor 8 [Source:NCBI gene;Acc:100038274])

HSP 1 Score: 423.705 bits (1088), Expect = 3.695e-139
Identity = 236/547 (43.14%), Postives = 329/547 (60.15%), Query Frame = 3
Query:  117 NCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVC-TIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPE----NNLCIRD-NQTEKESAPNV--------SLSCPKSL------------------------QIPVSYDF-----KIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFL-NDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLC 1625
            +C++I VP C+ + Y  T  PN   H TQDEA +E++++ PL+ I C   L+ FLCS+Y P+C    KK LPPCRS+C + +  C P+++++ F WP  M CD  PE    + LC+   N+TE+ +A           + S PK                           +PV+ +      ++R  Q   I +C +PC+  YF+ P  R F   W+ LWS +C  ST  TV TFLIDM+RF+YPERPIIFLSACYL+V   Y+      ++KVAC+     +        I  + T    C ++F+L+YFF MAS+IWWV+L++TW+LAA   W +E+I   SQYFH AAW +P+ K+I +LALS VDGDP+ G+CF G  +   LRGF++APL IYL IG+ FL+AGFVS+F IR++IK GG+KTDKLEKL+ RIGIFSVLY VPA +V+AC+F+E  N     Q W +   C S + +                  +   ++P++ +FM+KY M L+VGITSG+WIWSGKTL SW+ F +R C
Sbjct:   26 SCQEITVPLCKDIGYNYTYMPNQFNHDTQDEAGMEVHQFWPLVVIHCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERARAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYYNRTEQTTAAPSHPEPPKPPARSAPKGRTRVEPPRPRPRAPGCEPGCQCRAPMVPVTNERHPLYNRVRTGQ---IPNCAMPCHNPYFS-PEERTFTEFWIGLWSVLCFASTFATVSTFLIDMERFKYPERPIIFLSACYLLVSAGYLVRLIAGHEKVACS-----RGELDLEHIIHYETTGPALCTLVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSIKSIAVLALSSVDGDPVAGICFVGNQNLDNLRGFVLAPLVIYLFIGSMFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFSVLYTVPATIVVACFFYEQHN----RQGWEVAHNCNSCQPE------------------VAQPRRPDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWRAFCTRCC 541          
BLAST of Fzd-1/2/7 vs. Ensembl Xenopus
Match: FZD9 (frizzled class receptor 9 [Source:NCBI gene;Acc:100487936])

HSP 1 Score: 397.127 bits (1019), Expect = 5.847e-129
Identity = 215/519 (41.43%), Postives = 307/519 (59.15%), Query Frame = 3
Query:  108 NQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCT-IMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENN----LCIR--DNQTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQD----------CG---IPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWK 1604
             +  CE I++P CQG+ Y MT  PN++ H +Q+EAA ++ E+ PL+   CH  L+ FLCSLY P+CT  +  ++P C+ +C   +++C PI++ F + WP+S+ CD  P  N    LC+   +N T  +   N     P + + P      I +S      D          C    IP    Y++  + + FA VW+A WS +C  ST FTV TFL+  +RFQYPE+PIIFLS CY V    Y   F +  + A   P    D  G  P ++ +G +   C ++F++LY+F MAS++WWVVLT+TW+LAA   W HE+I  +  YFH AAW IPA KTI IL + KV GD LTG+C+ G SDPS L GF++ PL  YL+ GT FL+ GFV++F IR ++KTGG+ T+KLEKL+ +IG+FS+LY VPA  +I C F+E +NL  W  R            ++ C+ +    P +   +  +    P   +FM+K  MSL VGITSG+W+WS KTL +W+
Sbjct:   24 REAKCEPIQIPMCQGIGYNMTRMPNYVGHESQEEAAAKLQEFAPLVEYGCHIHLRFFLCSLYAPMCTEQVSTSIPACKPMCEAARQKCAPIMESFQYVWPESLDCDRLPSKNDPHALCMEAPENATNGDPPTNGHGMLPVAPRPPRPSGSGIGISSRCANPDKFMYVERSGVCAPRCIPGVDVYWSSGD-KDFALVWMAAWSGLCFISTAFTVFTFLLHPQRFQYPEKPIIFLSMCYNV----YSTAFLI--RAAAGAPSIACDREGGAPYLIREGLESSGCTLVFLILYYFGMASSLWWVVLTLTWFLAASKKWGHEAIESHGSYFHLAAWGIPAIKTIIILTMRKVGGDELTGLCYVGGSDPSALTGFVLVPLSCYLVTGTSFLLTGFVALFHIRRVMKTGGTNTEKLEKLMVKIGVFSILYTVPATCIIVCCFYERLNLAHWDSR----------AREESCRTV----PGSARPDCNLPHSIPSVAVFMLKIFMSLAVGITSGVWVWSSKTLQAWQ 521          
BLAST of Fzd-1/2/7 vs. Ensembl Mouse
Match: Fzd1 (frizzled class receptor 1 [Source:MGI Symbol;Acc:MGI:1196625])

HSP 1 Score: 500.36 bits (1287), Expect = 3.676e-168
Identity = 262/556 (47.12%), Postives = 354/556 (63.67%), Query Frame = 3
Query:   78 NNIRAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP---ENNLCIRDNQTEKESAPNVSL--------------------------------SCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCN------RYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            N  R ++ P +   C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++ALPPCRSLC + ++ CE ++ KF F+WP ++ C+ +P      LC+  N ++K   P  SL                                SCP++L++P   ++   L +    +DCG PC         YF    LR F+R W+ +WS +C  STLFTVLT+L+DM+RF YPERPIIFLS CY  V + Y+AGF L D+V C   F    +     + V QGTK E C ILFM+LYFFSMAS+IWWV+L++TW+LAA   W HE+I  NSQYFH AAWA+PA KTI ILAL +VDGD L+GVCF GL++   LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIG+FSVLY VPA +VIACYF+E     +W + W +   C+S  Y   C  +         G        P+F +FMIKYLM+LIVGITSG WIWSGKTL SW+ F++RL
Sbjct:   98 NGERGISIP-DHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDK-GTPTPSLLPEFWTSNPQHGGGGYRGGYPGGAGTVERGKFSCPRALRVPSYLNYHF-LGE----KDCGAPCEPTKVYGLMYFGPEELR-FSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGA-----RTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSW-VAQSCKS--YAIPCPHLQGGG-----GVPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRL 632          
BLAST of Fzd-1/2/7 vs. Ensembl Mouse
Match: Fzd7 (frizzled class receptor 7 [Source:MGI Symbol;Acc:MGI:108570])

HSP 1 Score: 488.804 bits (1257), Expect = 1.108e-164
Identity = 254/540 (47.04%), Postives = 347/540 (64.26%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP---ENNLCIRDNQ-----------TEKESAP-------------------NVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNR------YYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++ +A+PPCRSLC + ++ CE ++ KF F+WP+ + C+ +P      +C+  N            T   +AP                   +   SCP+ L++P    ++  L +    +DCG PC         YF E   R+FAR+WV +WS +C  STLFTVLT+L+DM+RF YPERPIIFLS CY +V + +VAGF L D+  C   F++        + V QGTK E C ILFM+LYFF MAS+IWWV+L++TW+LAA   W HE+I  NSQYFH AAWA+PA KTI ILA+ +VDGD L+GVC+ GLS    LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIG+FSVLY VPA +V+ACYF+E      W + W L+  C+S  Y   C   H   P++           P+F +FMIKYLM++IVGIT+G WIWSGKTL SW+ F+ RL
Sbjct:   49 CQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGAGGSPTAYPTAPYLPDPPFTAMSPSDGRGRLSFPFSCPRQLKVPPYLGYRF-LGE----RDCGAPCEPGRANGLMYFKEEE-RRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGY-----RTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTW-LLQTCKS--YAVPCPPGH-FSPMS-----------PDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRL 562          
BLAST of Fzd-1/2/7 vs. Ensembl Mouse
Match: Fzd2 (frizzled class receptor 2 [Source:MGI Symbol;Acc:MGI:1888513])

HSP 1 Score: 476.478 bits (1225), Expect = 7.070e-160
Identity = 246/543 (45.30%), Postives = 343/543 (63.17%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPEN---NLCIRDNQTEK------ESAPNVSLS---------------------------CPKSLQIPVSYDFKIRLSQNSVIQDCGIPCN------RYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++A+PPCRS+C + ++ CE ++ KF F+WP+ + C+ +P +    +C+  N +E        +AP   L                            CP+ L++P    +K  L +    +DC  PC         +F++   R FAR+W+  WS +C  ST FTV T+L+DM+RF+YPERPIIFLS CY +V + Y+AGF L ++V C   F+         + VVQGTK E C ILFM+LYFFSMAS+IWWV+L++TW+LAA   W HE+I  NSQYFH AAWA+PA KTI ILA+ ++DGD L+GVCF GL+    LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLE+L+ RIG+FSVLY VPA +VIACYF+E      W + W              CK +    P +           P+F ++MIKYLM+LIVGITSG WIWSGKTL SW+ F++RL
Sbjct:   44 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPSGLQPGAGGTPGGPGGGGSPPRYATLEHPFHCPRVLKVPSYLSYKF-LGE----RDCAAPCEPARPDGSMFFSQEETR-FARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSEDGY-----RTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSW----------VSQHCKSLAIPCPAHYTPR-----MSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRL 560          
BLAST of Fzd-1/2/7 vs. Ensembl Mouse
Match: Fzd5 (frizzled class receptor 5 [Source:MGI Symbol;Acc:MGI:108571])

HSP 1 Score: 423.705 bits (1088), Expect = 3.411e-139
Identity = 233/544 (42.83%), Postives = 326/544 (59.93%), Query Frame = 3
Query:  108 NQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVC-TIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP-----ENNLCIRDNQTEKESA-----------------PNVSLSCP---------KSLQIPVSYDF-----KIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFL-NDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLC 1625
              P C++I VP C+G+ Y +T  PN   H TQDEA LE++++ PL+ I C   L+ FLCS+Y P+C     K LPPCRS+C + K  C P+++++ F WP+ MSCD  P        LC+  N++E  +A                 P+    CP         +   +P+  +      K+R  Q   + +C +PC +  F+ P+ R FA  W+ LWS +C  ST  TV TFLIDM+RF+YPERPIIFLSACYL V L ++    + +  VAC+   ++       P +         C ++F+L+YFF MAS+IWWV+L++TW+LAA   W +E+I   +QYFH AAW IP+ K+I  LALS VDGDP+ G+C+ G  + ++LRGF++ PL +YLL+GT FL+AGFVS+F IR++IK GG+KTDKLEKL+ RIGIF++LY VPA +V+ACY +E      + + W     C                   PG +A     KPE+ + M+KY M L+VGITSG+WIWSGKTL SW+ F SR C
Sbjct:   29 KAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIHCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGGDAEVLCMDYNRSEATTASPKSFPAKPTLPGPPGAPSSGGECPSGGPSVCTCREPFVPILKESHPLYNKVRTGQ---VPNCAVPCYQPSFS-PDERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREHSHIHYETTGPAL---------CTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQ----HYRESWEAALTCAC-----------------PGPDAGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTLESWRRFTSRCC 538          
BLAST of Fzd-1/2/7 vs. Ensembl Mouse
Match: Fzd5 (frizzled class receptor 5 [Source:MGI Symbol;Acc:MGI:108571])

HSP 1 Score: 423.705 bits (1088), Expect = 3.411e-139
Identity = 233/544 (42.83%), Postives = 326/544 (59.93%), Query Frame = 3
Query:  108 NQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVC-TIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP-----ENNLCIRDNQTEKESA-----------------PNVSLSCP---------KSLQIPVSYDF-----KIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFL-NDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLC 1625
              P C++I VP C+G+ Y +T  PN   H TQDEA LE++++ PL+ I C   L+ FLCS+Y P+C     K LPPCRS+C + K  C P+++++ F WP+ MSCD  P        LC+  N++E  +A                 P+    CP         +   +P+  +      K+R  Q   + +C +PC +  F+ P+ R FA  W+ LWS +C  ST  TV TFLIDM+RF+YPERPIIFLSACYL V L ++    + +  VAC+   ++       P +         C ++F+L+YFF MAS+IWWV+L++TW+LAA   W +E+I   +QYFH AAW IP+ K+I  LALS VDGDP+ G+C+ G  + ++LRGF++ PL +YLL+GT FL+AGFVS+F IR++IK GG+KTDKLEKL+ RIGIF++LY VPA +V+ACY +E      + + W     C                   PG +A     KPE+ + M+KY M L+VGITSG+WIWSGKTL SW+ F SR C
Sbjct:   29 KAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIHCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGGDAEVLCMDYNRSEATTASPKSFPAKPTLPGPPGAPSSGGECPSGGPSVCTCREPFVPILKESHPLYNKVRTGQ---VPNCAVPCYQPSFS-PDERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREHSHIHYETTGPAL---------CTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQ----HYRESWEAALTCAC-----------------PGPDAGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTLESWRRFTSRCC 538          
BLAST of Fzd-1/2/7 vs. UniProt/SwissProt
Match: sp|Q9I9M5|FZD1_XENLA (Frizzled-1 OS=Xenopus laevis OX=8355 GN=fzd1 PE=1 SV=1)

HSP 1 Score: 503.056 bits (1294), Expect = 1.795e-169
Identity = 264/540 (48.89%), Postives = 357/540 (66.11%), Query Frame = 3
Query:   78 NNIRAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENN---LCIRDNQTEKES-APNV--------------SLSCPKSLQIP--VSYDFKIRLSQNSVIQDCGIPC-----NRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            N  + ++ P +   C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++ALPPCRSLC + ++ CE ++ KF F+WP+S+ C+ +P N    LC+  N TE  +  P V                 CP++L++P  V+Y F   L +    +DCG PC     +   +  P    FAR+W+ +WS +C  STLFTVLT+L+DMKRF YPERPIIFLS CY +V + Y+AGF L DKV C   F          K V QGTK E C  LFM+LYFFSMAS+IWWV+L++TW+LAA   W HE+I  NSQYFH AAWA+PA KTI ILA+ +VDGD L+GVCF G+++   LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIGIFSVLY VPA +VIACYF+E     +W + W +   C++  Y   C     H P++           P+F +FMIKYLM+LIVGITSG WIWSGKTL SW+ F++RL
Sbjct:   38 NGEKGISIP-DHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELKFFLCSIYAPVCTVLEQALPPCRSLCDRARQGCEALMNKFGFQWPESLRCEKFPINGAGELCVGQNTTESGTPTPAVPETWTSNSRTYYRDKFMCPRALKVPAYVNYHF---LGE----KDCGAPCEVGKVHGLMYFAPEELNFARIWIGIWSVLCCASTLFTVLTYLVDMKRFSYPERPIIFLSGCYTMVAIAYIAGFLLEDKVVCNERFAEDGY-----KTVAQGTKKEGCTFLFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILAVGQVDGDTLSGVCFVGINNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFREQWEKSW-ISQSCKT--YAIPCPST-GHPPMS-----------PDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRL 549          
BLAST of Fzd-1/2/7 vs. UniProt/SwissProt
Match: sp|O57328|FZD1_CHICK (Frizzled-1 OS=Gallus gallus OX=9031 GN=FZD1 PE=2 SV=1)

HSP 1 Score: 502.286 bits (1292), Expect = 8.965e-169
Identity = 262/550 (47.64%), Postives = 356/550 (64.73%), Query Frame = 3
Query:   87 RAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP---ENNLCIRDNQTEKESAPNVSL---------------------------SCPKSLQIPVSYDFKIRLSQNSVIQDCGIPC------NRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHD--HKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            R ++ P +   C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++ALPPCRSLC + ++ CE ++ KF F+WP ++ C+ +P      LC+  N +E+   P  +L                           SCP++L++P   +++  L +    +DCG PC         YF    LR F+R W+ +WS +C  STLFTVLT+L+DMKRF YPERPIIFLS CY  V + Y+AGF L ++V C   F    S     + V QGTK E C ILFM+LYFF MAS+IWWV+L++TW+LAA   W HE+I  NSQYFH AAWA+PA KTI ILAL +VDGD L+GVCF G+++   LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIGIFSVLY VPA +VIACYF+E     +W + W +   C+S  Y   C   H   H P++           P+F +FMIKYLM+LIVGITSG WIWSGKTL SW+ F++RL
Sbjct:   60 RGISIP-DHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLRCEKFPVHGAGELCVGQNASER-GTPTPALRPESWTSNPHRGGGAGGSGPGEARGRFSCPRALKVPSYLNYRF-LGE----KDCGAPCEPGRLYGLMYFGPEELR-FSRTWIGIWSVLCCASTLFTVLTYLVDMKRFSYPERPIIFLSGCYTAVAVAYIAGFLLEERVVCNERFAEDGS-----RTVAQGTKREGCTILFMMLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGINNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFREQWERSW-VTQSCKS--YAIPCPNNHSSHHPPMS-----------PDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRL 582          
BLAST of Fzd-1/2/7 vs. UniProt/SwissProt
Match: sp|Q9UP38|FZD1_HUMAN (Frizzled-1 OS=Homo sapiens OX=9606 GN=FZD1 PE=1 SV=2)

HSP 1 Score: 502.286 bits (1292), Expect = 6.378e-168
Identity = 263/556 (47.30%), Postives = 355/556 (63.85%), Query Frame = 3
Query:   78 NNIRAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP---ENNLCIRDNQTEKESAPNVSL--------------------------------SCPKSLQIPVSYDFKIRLSQNSVIQDCGIPC------NRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            N  R ++ P +   C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++ALPPCRSLC + ++ CE ++ KF F+WP ++ C+ +P      LC+  N ++K   P  SL                                SCP++L++P   ++   L +    +DCG PC         YF    LR F+R W+ +WS +C  STLFTVLT+L+DM+RF YPERPIIFLS CY  V + Y+AGF L D+V C   F    +     + V QGTK E C ILFM+LYFFSMAS+IWWV+L++TW+LAA   W HE+I  NSQYFH AAWA+PA KTI ILAL +VDGD L+GVCF GL++   LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIG+FSVLY VPA +VIACYF+E     +W + W +   C+S  Y   C  +        GG        P+F +FMIKYLM+LIVGITSG WIWSGKTL SW+ F++RL
Sbjct:  103 NGERGISVP-DHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDK-GTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHF-LGE----KDCGAPCEPTKVYGLMYFGPEELR-FSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGA-----RTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSW-VAQSCKS--YAIPCPHLQAG-----GGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRL 637          
BLAST of Fzd-1/2/7 vs. UniProt/SwissProt
Match: sp|O70421|FZD1_MOUSE (Frizzled-1 OS=Mus musculus OX=10090 GN=Fzd1 PE=1 SV=3)

HSP 1 Score: 500.36 bits (1287), Expect = 2.571e-167
Identity = 262/556 (47.12%), Postives = 354/556 (63.67%), Query Frame = 3
Query:   78 NNIRAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP---ENNLCIRDNQTEKESAPNVSL--------------------------------SCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCN------RYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            N  R ++ P +   C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++ALPPCRSLC + ++ CE ++ KF F+WP ++ C+ +P      LC+  N ++K   P  SL                                SCP++L++P   ++   L +    +DCG PC         YF    LR F+R W+ +WS +C  STLFTVLT+L+DM+RF YPERPIIFLS CY  V + Y+AGF L D+V C   F    +     + V QGTK E C ILFM+LYFFSMAS+IWWV+L++TW+LAA   W HE+I  NSQYFH AAWA+PA KTI ILAL +VDGD L+GVCF GL++   LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIG+FSVLY VPA +VIACYF+E     +W + W +   C+S  Y   C  +         G        P+F +FMIKYLM+LIVGITSG WIWSGKTL SW+ F++RL
Sbjct:   98 NGERGISIP-DHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDK-GTPTPSLLPEFWTSNPQHGGGGYRGGYPGGAGTVERGKFSCPRALRVPSYLNYHF-LGE----KDCGAPCEPTKVYGLMYFGPEELR-FSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGA-----RTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSW-VAQSCKS--YAIPCPHLQGGG-----GVPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRL 632          
BLAST of Fzd-1/2/7 vs. UniProt/SwissProt
Match: sp|Q08463|FZD1_RAT (Frizzled-1 OS=Rattus norvegicus OX=10116 GN=Fzd1 PE=1 SV=1)

HSP 1 Score: 494.197 bits (1271), Expect = 5.786e-165
Identity = 262/556 (47.12%), Postives = 353/556 (63.49%), Query Frame = 3
Query:   78 NNIRAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP---ENNLCIRDNQTEKESAPNVSL--------------------------------SCPKSLQIPVSYDFKIRLSQNSVIQDCGIPC------NRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            N  R ++ P +   C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++ALPPCRSLC +  + CE ++ KF F+WP ++ C+ +P      LC+  N ++K   P  SL                                SCP++L++P   ++   L +    +DCG PC         YF    LR F+R W+ +WS +C  STLFTVLT+L+DM+RF YPERPIIFLS CY  V + Y+AGF L D+V C   F    +     + V QGTK E C ILFM+LYFFSMAS+IWWV+L++TW+LAA   W HE+I  NSQYFH AAWA+PA KTI ILAL +VDGD L+GVCF GL++   LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIG+FSVLY VPA +VIACYF+E     +W + W +   C+S  Y   C  +         G        P+F +FMIKYLM+LIVGITSG WIWSGKTL SW+ F++RL
Sbjct:   98 NGERGISIP-DHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLC-ERAQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDK-GTPTPSLLPEFWTSNPQHGGGGYRGGYPGGAGPVERGKFSCPRALRVPSYLNYHF-LGE----KDCGAPCEPTKVYGLMYFGPEELR-FSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGA-----RTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSW-VAQSCKS--YAIPCPHLQGGG-----GVPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRL 631          
BLAST of Fzd-1/2/7 vs. TrEMBL
Match: T1E1C6 (Fzd-1/2/7 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 1250.73 bits (3235), Expect = 0.000e+0
Identity = 637/637 (100.00%), Postives = 637/637 (100.00%), Query Frame = 3
Query:   30 MLIKYFLIVSFVFLFINNIRAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLNPGDPWTRSDWLEKNNGYYQRHFVGPTANKMIIQGCDDKQAIPLXXXXXXXXXXXXXXXXXXKPLLSNVPESILNAQAQNGNLLPPSQQIGDSKTQKIGFMM 1940
            MLIKYFLIVSFVFLFINNIRAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSVLYVVPAVVVIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLNPGDPWTRSDWLEKNNGYYQRHFVGPTANKMIIQGCDDKQAIPLQYQFPQQTQQTIGTQELQKPLLSNVPESILNAQAQNGNLLPPSQQIGDSKTQKIGFMM
Sbjct:    1 MLIKYFLIVSFVFLFINNIRAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSVLYVVPAVVVIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLNPGDPWTRSDWLEKNNGYYQRHFVGPTANKMIIQGCDDKQAIPLQYQFPQQTQQTIGTQELQKPLLSNVPESILNAQAQNGNLLPPSQQIGDSKTQKIGFMM 637          
BLAST of Fzd-1/2/7 vs. TrEMBL
Match: T1E112 (Fzd-1/2/7 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1)

HSP 1 Score: 982.63 bits (2539), Expect = 0.000e+0
Identity = 502/646 (77.71%), Postives = 556/646 (86.07%), Query Frame = 3
Query:   30 MLIKY--FLIVSFVFLFINNIRAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKD-STGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHD-HKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLNPGDPWTRSDWLEKNNGYYQRHFVGPTANKMIIQGCDDKQAIPLXXXXXXXXXXXXXXXXXXKPLLS-----NVPESILNAQAQNGNLLPPSQQIGDSKTQKIGFMM 1940
            ML K+  FL +  +FL +N   AVNDPYNQ  CEKIKV ACQGLLY MT+FPN M HSTQDEAA EINEY+PL+RIKCH SLQLFLCSLYFPVCT MK ALPPCRSLC  IKK CEPILKKFYFKWP +M+CD YPENNLCI+DNQ EK+    +S+SCPK L++P SYDFK+R S NSVI DCGIPCNRY+FNEPNL+KF RVWVALWSF+CV STLFTVLTFLIDM+RFQYPERPIIFLSACYLVVGLTYVAGFFLND+VACAGPF+N D    + PKIVVQGTKFESCII+FMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESI RNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDP+ L+GFLIAPLC+YLLIGT FLIAGFVSMFEIR+IIKTGG+KTDKLEKLITRIGIFSVLY+VPAVVVIACYFHESMNL+KWMQRW+ +D+CRS +Y+  C K  D +K I P  +  + +QKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYF S+LCGRL  G PWTRS WLE++N Y+QRHF G TANKM+I  CDD Q + +QYQ  QQ QQ+IG QELQKPLLS      V E+++NAQ  NGNLLP +QQIGD K QK+G+MM
Sbjct:    3 MLFKWNIFLCIFLIFLTVN--EAVNDPYNQAKCEKIKVQACQGLLYDMTLFPNSMGHSTQDEAASEINEYLPLLRIKCHNSLQLFLCSLYFPVCTNMKIALPPCRSLCEDIKKSCEPILKKFYFKWPSNMACDKYPENNLCIKDNQAEKKPNETMSISCPKPLKVPPSYDFKVRYSSNSVIPDCGIPCNRYFFNEPNLKKFTRVWVALWSFLCVASTLFTVLTFLIDMQRFQYPERPIIFLSACYLVVGLTYVAGFFLNDRVACAGPFSNSDLRPNEVPKIVVQGTKFESCIIMFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIERNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPNALQGFLIAPLCLYLLIGTAFLIAGFVSMFEIRSIIKTGGTKTDKLEKLITRIGIFSVLYIVPAVVVIACYFHESMNLHKWMQRWFWVDVCRSPDYRKYCDKNVDLNKIIKPDSSMYLLNQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFLSKLCGRLEVGAPWTRSGWLERSNSYHQRHFAGLTANKMMINPCDDNQVMAMQYQMVQQNQQSIGNQELQKPLLSCHNGTGVTENMMNAQTLNGNLLPSNQQIGDPKNQKLGYMM 646          
BLAST of Fzd-1/2/7 vs. TrEMBL
Match: A0A3Q0KT77 (Putative frizzled OS=Schistosoma mansoni OX=6183 PE=3 SV=1)

HSP 1 Score: 691.804 bits (1784), Expect = 0.000e+0
Identity = 340/553 (61.48%), Postives = 417/553 (75.41%), Query Frame = 3
Query:   24 INMLIKYFLIVSFVFLFINNI--RAVNDPYNQ-PNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTG---KTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKI---HDHKPINPGGNAL------------IFS-----QKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWK 1604
            + M ++   IV  +F   N    R + DPY + P CE I++ ACQ L Y +TIFPN M H+TQD+AA EI +Y PL+R  C  SL+LFLCSL+FPVCT MKK LPPCRSLC Q +K+CEP+++ F+F+WP+ M+CD +PE++LCI +N+TEK  +   S  CP  +++P S++F++R+ +N +IQDCGIPC  + F + + RKF+R+W+ LWSF+C  ST FTVLTFLIDM RFQYPERPIIFLSACYL+V LTYVAGF LND VAC+GPF    S     + P++V QGTKFE CI+LFMLLYFFSMAS+IWWVVLTITWYLAAKCHWAHE+I RN+QY HFAAWAIPA KTIGILAL KVDGDPL+GVCFTGL+DP  LR FLIAPLC+YLLIGT FL AGFVS+F+IRTIIKTGGSKTD LEKLI RIG+FS+LY+VPA+VVIACY HES    KWM  WY  ++CR  +       I   H  + +  G +              IF+     +KPEFELFMIKYLM+L+VGITSG+WIWSGKTL+SWK
Sbjct:    1 MAMCLRALFIVVHIFSHSNCYIQRGLEDPYAETPKCEPIRIKACQDLPYNITIFPNDMGHATQDDAAQEIGQYTPLVRTTCSSSLKLFLCSLFFPVCTGMKKPLPPCRSLCEQNRKDCEPLMRGFHFEWPKIMNCDRFPEDSLCIAENKTEKRPSKEPSFVCPVHMKVPPSFEFRVRMGRNQIIQDCGIPCGDFLFGDSSSRKFSRLWIGLWSFLCAASTSFTVLTFLIDMPRFQYPERPIIFLSACYLMVALTYVAGFILNDSVACSGPFPAPQSLSGQIEMPRLVTQGTKFEGCIVLFMLLYFFSMASSIWWVVLTITWYLAAKCHWAHEAISRNAQYLHFAAWAIPAAKTIGILALGKVDGDPLSGVCFTGLTDPVILRAFLIAPLCLYLLIGTCFLFAGFVSLFKIRTIIKTGGSKTDDLEKLIMRIGVFSLLYIVPALVVIACYLHESRMSEKWMLTWYTTEVCRKVDPNQLADSICPGHFKRLVEAGSSTSRSDNSDISVSQNIFAKIPALEKPEFELFMIKYLMTLVVGITSGVWIWSGKTLVSWK 553          
BLAST of Fzd-1/2/7 vs. TrEMBL
Match: A0A075FFK0 (Frizzled-like protein OS=Schistosoma mansoni OX=6183 GN=Fz1 PE=2 SV=1)

HSP 1 Score: 691.419 bits (1783), Expect = 0.000e+0
Identity = 340/551 (61.71%), Postives = 416/551 (75.50%), Query Frame = 3
Query:   30 MLIKYFLIVSFVFLFINNI--RAVNDPYNQ-PNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTG---KTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKI---HDHKPINPGGNAL------------IFS-----QKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWK 1604
            M ++   IV  +F   N    R + DPY + P CE I++ ACQ L Y +TIFPN M H+TQD+AA EI +Y PL+R  C  SL+LFLCSL+FPVCT MKK LPPCRSLC Q +K+CEP+++ F+F+WP+ M+CD +PE++LCI +N+TEK  +   S  CP  +++P S++F++R+ +N +IQDCGIPC  + F + + RKF+R+W+ LWSF+C  ST FTVLTFLIDM RFQYPERPIIFLSACYL+V LTYVAGF LND VAC+GPF    S     + P++V QGTKFE CI+LFMLLYFFSMAS+IWWVVLTITWYLAAKCHWAHE+I RN+QY HFAAWAIPA KTIGILAL KVDGDPL+GVCFTGL+DP  LR FLIAPLC+YLLIGT FL AGFVS+F+IRTIIKTGGSKTD LEKLI RIG+FS+LY+VPA+VVIACY HES    KWM  WY  ++CR  +       I   H  + +  G +              IF+     +KPEFELFMIKYLM+L+VGITSG+WIWSGKTL+SWK
Sbjct:    1 MCLRALFIVVHIFSHSNCYIQRGLEDPYAETPKCEPIRIKACQDLPYNITIFPNDMGHATQDDAAQEIGQYTPLVRTTCSSSLKLFLCSLFFPVCTGMKKPLPPCRSLCEQNRKDCEPLMRGFHFEWPKIMNCDRFPEDSLCIAENKTEKRPSKEPSFVCPVHMKVPPSFEFRVRMGRNQIIQDCGIPCGDFLFGDSSSRKFSRLWIGLWSFLCAASTSFTVLTFLIDMPRFQYPERPIIFLSACYLMVALTYVAGFILNDSVACSGPFPAPQSLSGQIEMPRLVTQGTKFEGCIVLFMLLYFFSMASSIWWVVLTITWYLAAKCHWAHEAISRNAQYLHFAAWAIPAAKTIGILALGKVDGDPLSGVCFTGLTDPVILRAFLIAPLCLYLLIGTCFLFAGFVSLFKIRTIIKTGGSKTDDLEKLIMRIGVFSLLYIVPALVVIACYLHESRMSEKWMLTWYTTEVCRKVDPNQLADSICPGHFKRLVEAGSSTSRSDNSDISVSQNIFAKIPALEKPEFELFMIKYLMTLVVGITSGVWIWSGKTLVSWK 551          
BLAST of Fzd-1/2/7 vs. TrEMBL
Match: C6ZDD0 (Frizzled 7 OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 681.019 bits (1756), Expect = 0.000e+0
Identity = 335/553 (60.58%), Postives = 418/553 (75.59%), Query Frame = 3
Query:   24 INMLIKYFLIVSFVFLFINNI--RAVNDPYNQ-PNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTG---KTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKI---HDHKPINPGGNAL------------IFS-----QKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWK 1604
            +++ ++  +IV+ +F   N    R + DPY + P CE I++ ACQ L Y +TIFPN M H+TQD+AA EI +Y PL+R  C  SL+LFLCSL+FPVCT MKK LPPCRSLC Q +K+CEP+++ F+F+WP+ M+CD +PE++LCI +N+TEK  +   S  CP  +++P S++F+IR+  N VI DCGIPC+ + F + + R+F+R+W+ LWS +C  STLFTVLTFLIDM RFQYPERPIIFLSACYL+V LTYVAGF LN++VAC+GPF    S     + P+++ QGTKFE CI+LFMLLYFFSMAS+IWWVVLTITWYLAAKCHWAHE+I RN+QY H AAWAIPA KTIGILAL KVDGDPL+GVCFTGL+DP  LR FLIAPLC+YLLIGT FL AGFVS+F+IRTIIKTGGSKTD LEKLI RIG+FS+LY+VPA+VVIACY HES    KWM  WY  ++CR  +       I   H  + +    +              IF+     ++PEFELFMIKYLM+LIVGITSGIWIWSGKTL+SW+
Sbjct:    1 MHLTLRVLVIVAHIFSHSNCYVQRGLEDPYAETPKCEPIRIKACQDLPYNITIFPNDMGHATQDDAAQEIGQYTPLVRTTCSSSLKLFLCSLFFPVCTGMKKPLPPCRSLCEQNRKDCEPLMRGFHFEWPEIMNCDRFPEDSLCIAENKTEKRVSKEPSFVCPVHMRVPPSFEFRIRMGSNQVIHDCGIPCDDFLFGDSSSRRFSRLWIGLWSCLCAASTLFTVLTFLIDMPRFQYPERPIIFLSACYLMVALTYVAGFILNNEVACSGPFPAPQSLSGQIEMPRLITQGTKFEGCIVLFMLLYFFSMASSIWWVVLTITWYLAAKCHWAHEAISRNAQYLHSAAWAIPAAKTIGILALGKVDGDPLSGVCFTGLTDPVILRAFLIAPLCLYLLIGTCFLFAGFVSLFKIRTIIKTGGSKTDDLEKLIMRIGVFSLLYIVPALVVIACYLHESRMSEKWMLTWYTTEVCRKVDPNQLADSICPGHFRRLVEASSSTSRSDNSDGSISENIFAKISALERPEFELFMIKYLMTLIVGITSGIWIWSGKTLVSWQ 553          
BLAST of Fzd-1/2/7 vs. Ensembl Cavefish
Match: fzd7b (frizzled class receptor 7b [Source:ZFIN;Acc:ZDB-GENE-990415-229])

HSP 1 Score: 493.041 bits (1268), Expect = 1.869e-166
Identity = 252/529 (47.64%), Postives = 346/529 (65.41%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP---ENNLCIRDNQTEKES--------APNVS-----------LSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNR------YYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++A+PPCRSLC + +  CE ++ KF F+WP+ + C+ +P      +C+  N ++  S        AP ++            +CP  L +P   ++K   ++     DCG PC         YF E  + KF R+WV +W+ +C  STLFTVLT+L+DM+RF+YPERPIIFLS CY +V + YV GF L DKV C   F  +D+     + V QGTK E C ILFM+LYFF MAS+IWWV+L++TW+L+A   W HE+I  NSQYFH AAWA+PA KTI ILAL +VDGD LTGVCF G+ +   LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIG+FSVLY VPA +VIACYF+E     +W + W++            CK+        P  ++      P+F +FMIKYLM++IVGITSG WIWSGKTL SW+ F+ RL
Sbjct:   50 CQPISIPLCTDIQYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSADLKFFLCSMYAPVCTVLEQAIPPCRSLCERARHGCEALMNKFGFQWPERLRCEAFPVHGAGEICVGQNTSDPGSPTSEPTLYAPGLTPPPGPERSGQPFTCPLQLAVPSYLNYKFLGAK-----DCGAPCEHSQPHGLMYFREEEM-KFGRLWVGIWAILCCVSTLFTVLTYLVDMRRFRYPERPIIFLSGCYFMVAVAYVTGFLLEDKVVCIDKF-REDAY----RTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLSAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILALGQVDGDLLTGVCFVGIYNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFREQWEKTWHM----------QTCKRF-----AVPCPSSNFAPMSPDFTVFMIKYLMTMIVGITSGFWIWSGKTLQSWRSFYKRL 552          
BLAST of Fzd-1/2/7 vs. Ensembl Cavefish
Match: FZD7 (frizzled-7-A-like [Source:NCBI gene;Acc:103021589])

HSP 1 Score: 483.411 bits (1243), Expect = 1.085e-162
Identity = 251/543 (46.22%), Postives = 341/543 (62.80%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP---ENNLCIRDNQTEK-------ESAPN--------------------------VSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPC------NRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++A+PPCRSLC + +  CE ++ KF F+WP+ + C+ +P      +C+  N +E         S P                              +CP  L++P   ++     +     DCG PC         YF E  + KF R+WV +WS +C  STLFTVLT+L+DM+RF+YPERPIIFLS CY +V + Y AGFFL D+V C   F++        + V QGTK E C ILFM+LYFF MAS+IWWVVL++TW+L+A   W HE+I  N+QYFH AAWA+PA KTI ILAL +VDGD L GVC+ G+     LRGF++APL +YL +GT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIG+FSVLY VPA VVIACYF+E     +W + W++            CK+     P   G  A +    P+F +FMIKYLM++IVGITSG WIWSGKTL SW+ F+ RL
Sbjct:   45 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSADLKFFLCSMYAPVCTVLEQAIPPCRSLCERARHGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSEAAGGGAGATSEPTGYGREPLTLPPGAGGAGGIGSGGKSSPHFTCPLQLRVPSYLNYHFMGEK-----DCGAPCEPTKPNGLMYFREEEV-KFGRLWVGIWSVLCCASTLFTVLTYLVDMRRFRYPERPIIFLSGCYFMVAVAYAAGFFLEDRVVCIDRFSDDGY-----RTVAQGTKKEGCTILFMILYFFGMASSIWWVVLSLTWFLSAGMKWGHEAIEANAQYFHLAAWAVPAVKTITILALGQVDGDVLAGVCYVGVHSVDALRGFVLAPLFVYLFLGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATVVIACYFYEQAFRPQWERTWHM----------HTCKRF--AVPCPAGDFAPV---TPDFTVFMIKYLMTMIVGITSGFWIWSGKTLQSWRRFYKRL 561          
BLAST of Fzd-1/2/7 vs. Ensembl Cavefish
Match: ENSAMXT00000026985.2 (pep primary_assembly:Astyanax_mexicanus-2.0:19:27065879:27070162:-1 gene:ENSAMXG00000026259.2 transcript:ENSAMXT00000026985.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 424.476 bits (1090), Expect = 1.486e-139
Identity = 228/533 (42.78%), Postives = 320/533 (60.04%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVC-TIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP----ENNLCIRDNQTEKES-APNVSLSCPKSLQ---------IPVSYDFKIRLS-----------------QNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFL-NDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSR 1619
            CE I VP C+G+ Y +T  PN   H TQ+E  LE++++ PL+RI+C   L  FLCS+Y P+C    KK LPPCRS+C + K+ C P++ ++ F+WP+ MSC+  P     + LC+  N +E  + +P+     P+            +P   D + R                   Q   + +C +PC++ YF++ + R F   W+ LWS +C  STL TV TFLIDM+RF+YPERPIIFL+ACYL V L Y+      ++KVAC G       +G    I+   T    C ++F+L+YFF MAS+IWWVVL+ TW+LAA   W +E+I   SQYFH AAW +P+ K+I +LALS VDGDP+ G+C+ G     +LRGF++APL +YL  G+ FL+AGFVS+F IR++IK GG+KTDKLEKL+ RIG+F+VLY VPA +V+AC  +E     +W Q                C      + +            P++ +FM+KY M L+VGITSG+WIWSGKTL SW+ F +R
Sbjct:   37 CEPITVPMCKGIGYNLTYMPNQFNHDTQEEVGLEVHQFWPLVRIRCSPDLLFFLCSMYTPICLPDYKKPLPPCRSVCERAKRGCSPLMIQYGFEWPERMSCEQLPMLGDPDRLCMDQNSSETTTLSPSFPKPTPRGSSRHRATSKSAVPQKCDRECRCREPLVPIKKESHPLYNRVQTGSLPNCALPCHQPYFSQ-DERAFTTFWIGLWSVLCFVSTLTTVATFLIDMERFKYPERPIIFLAACYLFVSLGYIVRLLAGHEKVACGG-------SGDQRHILYDTTGPALCTLVFLLIYFFGMASSIWWVVLSFTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLESLRGFVLAPLVVYLFSGSLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGLFTVLYTVPATIVVACLVYEQHYRPEWEQ-----------ALGCSCASERQQQGLG-----------PDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWRRFVAR 539          
BLAST of Fzd-1/2/7 vs. Ensembl Cavefish
Match: fzd9a (frizzled class receptor 9a [Source:ZFIN;Acc:ZDB-GENE-060531-77])

HSP 1 Score: 390.963 bits (1003), Expect = 2.036e-126
Identity = 222/541 (41.04%), Postives = 312/541 (57.67%), Query Frame = 3
Query:   81 NIRAVNDPYNQP-NCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTI-MKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENN----LCIR--DNQT--------------EKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYY--FNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTY----VAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSR 1619
            +I A +    +P  CE I +P CQG+ Y MT  PN M + +Q+EA++++NE+ PL+   C   L+ FLCSLY P+CT  +   +P CR++C+Q +++C PI+++F F WP S+ C   P NN    LCI   +N T               +   P      P           K +  + S  + C   C+     F     + FA +W+ +WS +C  ST FTVLTFL+D +RFQYPERPIIFLS CY V  + +    VAG    + +AC       D       I+ +G +   C I+F++LY+F MAS+IWWV+LT+TW+LAA   W HE+I  +S YFH  AW IPA KTI IL + KV GD LTG+C+ G  D + L GF+I PL  YL+IGT F++ GFV++F IR I+KTGG+ T+KLEKL+ +IG+FS+LY VPA  VI CYF+E +N+  W  R            + +C       P     +  + S  P   +FM+K  MSL+VGITSG+W+WS KTL +W+   +R
Sbjct:   37 DIGAYDGERGRPAKCEPITIPMCQGIGYNMTRMPNFMKYESQEEASIKLNEFAPLVEYGCDVHLRFFLCSLYVPMCTDQVSTTIPACRAMCVQARQKCSPIMEQFSFGWPDSLDCSKLPTNNDPNALCIEAPENDTVPPTKKGEGMLPVPARPRPPGTGAGRPSGGSGSCENHEKFQYVEKS--ESCAPRCSPTVDVFWSRQDKDFAFIWMVVWSTLCFVSTAFTVLTFLLDPQRFQYPERPIIFLSMCYNVYSVAFIIRSVAG---AENIAC-------DRENGQLYIIQEGLESTGCTIVFLILYYFGMASSIWWVILTLTWFLAAGRKWGHEAIEAHSSYFHMVAWGIPAMKTIVILTMRKVAGDELTGLCYVGSMDTNALTGFIIIPLSCYLIIGTSFILTGFVALFHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIICYFYERLNMDYWKFR----------ASESKCVSF----PGRRTEDCTLDSSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTLQTWQGLCAR 551          
BLAST of Fzd-1/2/7 vs. Ensembl Cavefish
Match: fzd8a (frizzled class receptor 8a [Source:ZFIN;Acc:ZDB-GENE-000328-3])

HSP 1 Score: 384.415 bits (986), Expect = 1.833e-124
Identity = 222/540 (41.11%), Postives = 313/540 (57.96%), Query Frame = 3
Query:   51 IVSFVFLFINNI-RAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVC-TIMKKALP---PCRSLCLQIKKE----CEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESAPNVSLSCPKSLQIP-VSYDFKIRLSQNSV----IQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFL-NDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLC 1625
            I  F+FL +  + R+      +  C++I VP C+G+ Y  T  PN   H TQDEA LE++++ PL+ I+C   L+ FLCS+Y P+C    KK LP      +LC+   +       P+L K   +  +     + P      R      +  P          + P V  + +     N V    + +C +PC+  YF + + R F   W+ LWS +C  ST  TV TFLIDM+RF+YPERPIIFLSACY+ V + Y+      ++KVAC+  +           +  + T    C ++F+L+YFF MAS+IWWV+L++TW+LAA   W +E+I   SQYFH AAW IP+ K+I +LALS VDGDP+ G+C+ G  +   LRGF++APL IYL IGT FL+AGFVS+F IR++IK GG+KTDKLEKL+ RIGIF+VLY VPA +++ACYF+E  N   W             E    C  + +H+            ++P++ +FM+KY M L VGITSG+WIWSGKTL SW+   +R C
Sbjct:    8 IYLFLFLALGTLQRSSGTTAKELTCQEIAVPLCKGVGYNHTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLEDYKKPLPVQGDPDTLCMDYNRTDSTTASPVLSKPTGRPGKP---HVPPHRTKHGRPGVQPPKRKPGSPCDPGCQCRAPMVRVNSERHPLYNRVKTGQMPNCAMPCHNPYFTQ-DERTFTAFWIGLWSVLCFVSTFATVATFLIDMERFKYPERPIIFLSACYMFVSIGYIVRLIAGHEKVACSREY-------DVEHVHYETTGPALCTVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYSQYFHLAAWLIPSMKSIAVLALSSVDGDPVAGICYVGNQNLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTVLYTVPATIIVACYFYEQHNRQSW-------------ETSHNCSCLMEHE-----------LRRPDYAVFMLKYFMCLSVGITSGVWIWSGKTLDSWRALCTRCC 512          
BLAST of Fzd-1/2/7 vs. Ensembl Sea Lamprey
Match: fzd2 (frizzled class receptor 2 [Source:ZFIN;Acc:ZDB-GENE-990415-224])

HSP 1 Score: 490.345 bits (1261), Expect = 1.641e-166
Identity = 260/556 (46.76%), Postives = 351/556 (63.13%), Query Frame = 3
Query:   87 RAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP---ENNLCIRDNQTEKESAPNVS-----------------------------------LSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCN------RYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            RA++ P     C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT+++KA+PPCRSLC + ++ CE ++ KF F+WP+ + C+ +P    + +C+  N T+K     +                                      CP+ L++P   + ++   +N     C  PC         YF+E  LR F+R+WV +WS +C  STLFTV T+L+DM+RF+YPERPIIFLS CY +V + YVAGF L+DKV C     N+  +    + V QGTK E C ILFML+YFFSMAS+IWWVVL +TW+LAA   W HE+I  NSQYFH AAWAIPA KTI ILA+  VDGD L+GVCF G+S  + LRGF++APL +YL +GT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIGIFSVLY VPA +VIACYF+E     +W + W              CK      P+N   N      KP+F +FMIKYLM+LIVGITSG WIWSGKTL SW+ F+++L
Sbjct:    3 RAISVP-EHGFCQPISIPLCTDIPYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPDLKFFLCSMYAPVCTVLEKAIPPCRSLCDRARQGCEALMNKFGFQWPERLRCENFPVQGSDEICVGQNHTDKAGPTALPPTPPGGGGGVIGGIGGGAGDFVTIHTRRPPGRTHPFMCPRVLKVPPYLNAQLFRERN-----CAAPCEPKKPNGLMYFSEEELR-FSRLWVGIWSVLCCASTLFTVTTYLVDMQRFRYPERPIIFLSGCYFMVAVAYVAGFLLDDKVVC-----NEQFSEDIYRTVTQGTKKEGCTILFMLIYFFSMASSIWWVVLALTWFLAAGMKWGHEAIEANSQYFHLAAWAIPAVKTITILAMGLVDGDMLSGVCFVGISSVAALRGFVLAPLFVYLFLGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFREQWEKTW----------VSQSCKGFAIPCPLNHYPN-----MKPDFTVFMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTKL 531          
BLAST of Fzd-1/2/7 vs. Ensembl Sea Lamprey
Match: fzd7a (frizzled class receptor 7a [Source:ZFIN;Acc:ZDB-GENE-990415-223])

HSP 1 Score: 490.345 bits (1261), Expect = 1.152e-165
Identity = 260/561 (46.35%), Postives = 355/561 (63.28%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP---ENNLCIRDNQTEKESAPNV----------------------------------------------SLSCPKSLQIP--VSYDFKIRLSQNSVIQDCGIPCN------RYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGR 1631
            C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++A+PPCRSLC + ++ CE ++ KF F+WP+ + C+ +P     N+C+  N T+++                                                    L+CP  L++P  ++Y F  +       ++CG PC         YF+   L  FAR+WV +WS +C  STLFTVLT+L+DM+RF+YPERPIIFLS CY VV + Y+ GFF  +K+ C   F +  ST      VVQGTK E C ILFM+LYFFSMAS+IWWV+L++TW+L+A   W HE+I  NSQYFH AAWA+PA KTI ILA+ +VDGD LTGVCF GL+    LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIGIFSVLY VPA +VIACYF+E     +W + W +   C+S  +  +C +   H P          + KP+F +FMIKYLM+LIVGITSG WIWSGKTL SW+ F+SRL  +
Sbjct:   57 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPDLKFFLCSMYAPVCTVLEEAIPPCRSLCERARQGCETLMNKFGFQWPERLRCENFPVQGSENICVGQNHTDEKGGHPTPPDPHPIPHGDSFTLPPHYRPGGPSSGGGIGGGGGGGASGGDSSSYQLTCPHVLRVPSYLNYQFLGK-------KECGSPCEPSKSNGLMYFDADELW-FARMWVGVWSILCCASTLFTVLTYLVDMERFRYPERPIIFLSGCYAVVSIAYIVGFFFEEKIVCNKFFEDSYST------VVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLSAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILAMGQVDGDVLTGVCFVGLNSIDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFRAQWEKSW-VAHTCKS--FAVQCPQ--GHYP----------NMKPDFTVFMIKYLMTLIVGITSGFWIWSGKTLQSWRNFYSRLSNK 588          
BLAST of Fzd-1/2/7 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011009.1 (pep scaffold:Pmarinus_7.0:GL485859:2701:4509:1 gene:ENSPMAG00000009982.1 transcript:ENSPMAT00000011009.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 399.823 bits (1026), Expect = 1.565e-130
Identity = 223/549 (40.62%), Postives = 318/549 (57.92%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVC-TIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP----ENNLCIRDNQTE--------KESAPNVSLSCPK-------------------------SLQIPV------SYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFL-NDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIK-TGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCG 1628
            C+ I VP C+G+ Y  T  PN   H +QDEA LE++++ PL+ IKC   L+ FLCS+Y P+C    K+ LPPCRS+C + +  C P+++++ F WP  M CD  P    +N LC+  N+++        K +AP  S +  K                         + + P+       +    R+   SV+ +C +PC+  YF + + R FA  W+ LWS +C  ST  TV+TFLIDM+RF+YPERPIIFLSACY  V + Y+    + +D V C     +       P +         C ++F+L YFF MAS+IWWV+L++TW++AA   W+ E+I   SQY+H AAW +P+ +++ +LA S VD DPL G+C  G      LRGF++ PL +YL +G  FL+AGF S+  IR  IK  GG+KTDKLEKL+ RIGIFS+LY VPA+ V+ACYF+E  +   W +      IC S +         D +P    G+     Q+P++ +FM+KY M L+VGITSG+WIWSGKT+ +WK    R CG
Sbjct:    9 CQNITVPMCRGIGYNHTYMPNDFNHDSQDEAGLEVHQFWPLVEIKCSPDLRFFLCSMYTPICLEDYKQPLPPCRSVCERARAGCAPLMRQYGFAWPDRMRCDRLPVLGDQNRLCMDYNKSDTTPQPPEVKPTAPVRSFNPSKNRATTRVGGGGGGGGGSGEACESGCACRAPMVAIGSDRHPLYNRVRTGSVL-NCAMPCHDPYFTQ-DERTFASFWIGLWSILCFVSTFTTVVTFLIDMERFKYPERPIIFLSACYAFVSMGYIVRLVVGHDGVICNQEHRHVHYETTGPAL---------CTVVFLLTYFFGMASSIWWVILSLTWFMAAGMKWSSEAIAGYSQYYHLAAWLLPSVQSVAVLATSSVDADPLAGICSVGAQSLENLRGFVLVPLTVYLCVGAVFLLAGFTSLVRIRNAIKQQGGTKTDKLEKLMVRIGIFSMLYTVPAIAVVACYFYEERSRDGWARAL----ICPSCQ--------GDEEP----GSQQQQQQRPDYGIFMLKYFMCLVVGITSGVWIWSGKTVDTWKRLCCRCCG 530          
BLAST of Fzd-1/2/7 vs. Ensembl Sea Lamprey
Match: fzd8a (frizzled class receptor 8a [Source:ZFIN;Acc:ZDB-GENE-000328-3])

HSP 1 Score: 284.648 bits (727), Expect = 3.621e-89
Identity = 161/384 (41.93%), Postives = 225/384 (58.59%), Query Frame = 3
Query:  477 APNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFL-NDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKT--GGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSR 1619
            AP V +S P+     V YD ++R  Q   +++C  PC+  +      R FA  W+ LWS +C  +T  TV TFLIDM+RF+YPERPIIFLS C ++  L Y+      ++ VAC+  + +       P +         C  +F+L YFF MA  +WWV+L++TW++AA   W  E+I   SQY+H AAW +P+ K I  LA++ VDGDP+ G+C  G      LRGF++APL  YLL+GT FL+AG V++F IR  I    GG+KT+KLE+L+ RIG+F+VLY VPA V + C+ +E  +   W +      +C        C     H P  PG        +P+F +FM+KY + L+ GITSG WIWSGKT  SWK F+ R
Sbjct:    9 APLVRISNPRH----VLYD-RVRTGQ---VRNCATPCHSPFLGREQ-RTFASFWIGLWSSLCFAATFATVSTFLIDMERFKYPERPIIFLSLCCMLASLGYIVRMVAGHEAVACSADWHHVLYASSGPAL---------CTAVFLLTYFFGMAGCVWWVILSLTWFMAAGLKWGSEAIAGYSQYYHLAAWLLPSIKAIAALAMNAVDGDPVAGICSVGNQSLDNLRGFVLAPLVAYLLVGTAFLLAGLVALFRIRNAISANPGGAKTEKLERLMVRIGVFAVLYTVPAAVAVVCHLYEQQHRDSWER----TLVC------GACGPGPGHLP-EPG-------ARPDFAVFMLKYFVCLVGGITSGAWIWSGKTAGSWKRFYKR 356          
BLAST of Fzd-1/2/7 vs. Ensembl Sea Lamprey
Match: fzd3b (frizzled class receptor 3b [Source:ZFIN;Acc:ZDB-GENE-070122-1])

HSP 1 Score: 229.95 bits (585), Expect = 1.232e-67
Identity = 153/375 (40.80%), Postives = 215/375 (57.33%), Query Frame = 3
Query:  498 CPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVA-CAGPFTNKDSTGKTPKIVVQGTKF-ESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFS 1616
            CP+ L++P    +         + DC  PC   YF+   L +  R  V + S +C+ +T FT LTFL+D KRF+YPERPIIF + CY+ V L+++ GF L+D  A C  P     + G     V QG++  ++C  +FMLLYF +MA A+WWVVLTITW+LAA   W  E+I + +  FH  AW  PA  T+ +LAL+KV+GD L+GVC+ GL D +TLR F++APL      G   L+AG VS+  +R  ++  G    KL K + RIG+FSVLY+VP + ++AC  +E  +   W   W L D C   EY+  C     ++P           Q+P   LF++KY  +L+VGI    W+ S KT L W  F S
Sbjct:   10 CPRELKVPSGLGYSFM-----GVPDCSPPCPNMYFSSGEL-ELTRYLVGVMSVVCLVATTFTFLTFLLDRKRFRYPERPIIFYATCYVAVSLSFLVGFLLDDSAAACNAPGLAPGAAG----TVTQGSRNNKACTAVFMLLYFSAMAGALWWVVLTITWFLAAGLKWGREAIEKRAAAFHALAWGPPAALTVALLALNKVEGDNLSGVCYAGLYDVTTLRYFVLAPLGACAAAGLSLLLAGIVSLNRVRLEMRHDGRNQTKLVKFMVRIGVFSVLYLVPQLALVACLVYEQASRAAWEATW-LRDRC--TEYRIPC-PYQANQP----------KQRPALVLFLVKYFTTLVVGIPPAFWVGSRKTCLGWAAFLS 360          
BLAST of Fzd-1/2/7 vs. Ensembl Nematostella
Match: EDO35751 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKM6])

HSP 1 Score: 487.263 bits (1253), Expect = 5.963e-165
Identity = 250/527 (47.44%), Postives = 343/527 (65.09%), Query Frame = 3
Query:  117 NCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPE--NNLCIRDNQTEKESA----------PNVSLS-----CPKSLQIP-VSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLY----KWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGR 1631
             CE + +P C GL Y MTIFPN + H TQ+EAALE++++ PL+++ C   L  FLCS+Y PVCT+++  LPPCRSLCL ++  CE ++K+F F WP S+SC+ +P+  + +C+ +N T   S           P+V +S     CP+S +IP   Y F          + C   C   +F +   R+ AR+W  +W+ +C  STLFT+LTFLIDM+RF+YPERPIIFLS CY +V + ++ G+   DK+AC  P          PK +VQGTK E C ++FM+LYFFSMAS+IWWV+LT+TW+LAA   W  E+I  NSQ+FH AAWAIPA KTI IL ++KVDGD L+GVC+ GLSD S LRG+++APL +Y +IG  FL+AGF+S+F +R+++K   SK +K+EKL+ RIG+FS+LY VPA+VVI C ++E  N       W++ W     C   E K + +      P+          QKP+F +FM+KYLM LIVGITSG WIWS KTL SW+ F+ R   R
Sbjct:   28 RCEPVTIPLCTGLQYNMTIFPNTLKHRTQEEAALEVHQFFPLVKVDCSKDLAFFLCSVYAPVCTVLETPLPPCRSLCLTVRSGCEGLMKRFGFTWPDSLSCERFPKLGDEICVGENTTTPTSDQDGGINNNTYPDVDMSTMRYRCPESQKIPNDQYTFHGE-------KRCAATCRNVFFTKRE-REIARMWTGIWAILCAVSTLFTILTFLIDMRRFRYPERPIIFLSGCYFMVSIAFITGYVAGDKIACNEPIKKG-----FPKTLVQGTKHEGCTVIFMMLYFFSMASSIWWVILTVTWFLAAGLKWGQEAIEANSQFFHLAAWAIPAVKTIAILLMTKVDGDELSGVCYVGLSDVSALRGYVLAPLFVYFIIGATFLLAGFISLFRVRSVLKDDYSKREKIEKLMIRIGVFSILYTVPALVVIGCLYYEQSNRELWDNSWIEGWKRQKKCTEVETKLKGEVSCPPYPVP--------LQKPDFMVFMVKYLMFLIVGITSGFWIWSSKTLNSWRRFYRRFILR 533          
BLAST of Fzd-1/2/7 vs. Ensembl Nematostella
Match: EDO42932 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S003])

HSP 1 Score: 390.578 bits (1002), Expect = 1.941e-127
Identity = 227/566 (40.11%), Postives = 327/566 (57.77%), Query Frame = 3
Query:   18 LAINMLIKYFLIVSFVFLFINNIRAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIM-KKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPE----NNLCI-RDNQTEKESAPN-------------VSLSC----PKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDK-VAC-AGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGS-KTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLN 1637
            +A   L + F+ V+F+   +N +        +  CE+I +P C+G+ Y +T  PN   H TQ EAALE++++ PL+ I+C   L+ FLCS+Y P+C     K LPPCRS+C + +  C P+++K+ F WP+ M C+ +PE    N LC+ R++  E    P+             +S +C    P  + I        R      +  C + CNR YF   +   FA  W+ LW+ +C  STL T LTFL+DM RF+YPERPIIFLS CYL+V + Y+       K +AC +      D++G             SC I+F+L+YFF MAS++WWV+L  TW+L+A   W+ E+I   SQYFH  AW +PA + I +LA+S +DGDP++G+C+ G  +  +L  F+I PL +YL+ GT FL+AGF S+  IR +++  GS KTDKLEKL+ RIG+FSVLY VPA +V+ACY++E +N   W                         + IN  G   +   KP+  +F+IKY M+L+VGITSG WIWSGKT+ SW+ F +RL G  N
Sbjct:    1 MATRRLDRVFVAVAFISC-LNYVLT-----KEMKCEEITIPMCRGIGYNLTYMPNMFNHDTQAEAALEVHQFWPLVEIQCSPDLRFFLCSMYAPLCEKHYDKDLPPCRSVCERARTGCAPLMRKYGFSWPERMKCENFPELGDENTLCMGRNSSGESTPKPSQSPQPAPSPDTAAISANCCSCRPPFVSIAGKNIKPTRAISVGGVPQCAMACNRTYFTH-DQDSFASFWIGLWAILCFISTLVTTLTFLVDMHRFKYPERPIIFLSGCYLMVSVGYIIRLIAGHKQIACDSNGLMRYDTSGPA-----------SCTIVFLLVYFFGMASSVWWVILAFTWFLSAGMKWSSEAITNYSQYFHAVAWLVPAIQAIAVLAMSTIDGDPVSGICYVGNHNLQSLVVFVIVPLVVYLVFGTSFLMAGFYSLVRIRKLLRQHGSTKTDKLEKLMIRIGVFSVLYTVPATIVVACYYYELVNRETW------------------------ERTINCSGCG-VTRVKPDHSVFIIKYFMALVVGITSGFWIWSGKTIESWRNFCARLSGTQN 523          
BLAST of Fzd-1/2/7 vs. Ensembl Nematostella
Match: EDO38567 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCF4])

HSP 1 Score: 365.54 bits (937), Expect = 4.679e-117
Identity = 208/530 (39.25%), Postives = 295/530 (55.66%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTI-MKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKE------SAPNVSLSCP----------KSL-----QIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQG----TKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRW-YLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCG 1628
            C  I +P C G+ Y  T FPN +   +Q+EAA  I+E+ PL+ + C   L+ FLCS++ P+CT  +   +  CRS+C   +  C P++++F F WP ++ CD  P+      D Q + +      +APN+  + P          +SL     +I  +   + + +       C   C        N ++FA VW+++WS +C  ST  TVLTF+ID  RF+YPERPIIFLS CY +  L Y+           AG   N+    +T   V++          C ++F+LLY+F MASA+WWVVLT  W+LAA   W  E+I R + YFH  AW +PA +TI  L + KVD D LTG+C+ G  D   L  +++ PLC+YLL+GT FL+AGFVS+F IRT++K   + TDKLEKLI RIG+FSVLY +P   VIAC F+E  N+  W  R  +   ICR                   G  A + +  P  E+F++KY M LI+GITS +WIWS KT  SW+ F+S+  G
Sbjct:   32 CTPITIPLCMGIGYNATRFPNFLAQESQEEAAKRIHEFKPLIAVNCAPLLRFFLCSVFVPMCTKEVNVPIYACRSMCESARDGCSPMMQRFGFNWPDTLDCDRLPKKG----DPQAKSDPTKLCMAAPNIKQTAPLNESDIWSNFESLGPEFKKINNTGPLRYKYTYVEKYDQCVPQCKSDLMFSSNNKRFANVWISVWSVLCFISTAVTVLTFVIDTSRFKYPERPIIFLSLCYNLYSLGYIVR-------VTAG--RNEVICDETESFVIRAGMNIADHACCSVVFLLLYYFGMASAVWWVVLTFAWFLAAGRKWGQEAIERKATYFHAVAWTVPAIQTIMALIMRKVDADELTGLCYVGNMDYENLANYVLTPLCLYLLVGTFFLLAGFVSLFRIRTVLKNKETNTDKLEKLIVRIGVFSVLYTIPVSAVIACSFYEYNNMDVWKVRAPFNTYICR-------------------GDQACLENYGPSIEVFIVKYFMLLIIGITSNMWIWSTKTFKSWRKFYSKRKG 529          
BLAST of Fzd-1/2/7 vs. Ensembl Nematostella
Match: EDO30865 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZJ6])

HSP 1 Score: 311.997 bits (798), Expect = 9.880e-98
Identity = 193/525 (36.76%), Postives = 284/525 (54.10%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKC-HGSLQLFLCSLYFPVCT-IMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLY----PENNLCIRD---NQTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNS-------VIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDK-VACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGG-SKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLNP 1640
            CEKI +  C+ + Y +T  PN + H TQ EA  ++ +++PL++  C    L  FLCS Y P+CT  +   +  CR LC  ++K C P+L +F   WP  ++C  +     E N+C+      ++ ++  P+       + + P +   + R  +NS         + C + CN     + + ++   +W+ +WS  C  ST  T+ TFLI+  RF+YPER II+L+ CY    L+Y+       + ++C     + D T      +  G +   C I+F++ YFF MA+ IWWVVL +TW+LAA   W  E+IG  ++ FH  AW +P  KTI IL   KVDGD LTG+CF G  D   L  F++ P   YL+IGT FLIAGFV++F IRT ++ GG +KTDKLE+LI RIGIFSVL  VPA  VIACYF+E  N     + WY                          G       +P F +FM+K  MSL  G+ +G+WIWS KT+ +W+ F+ ++ G+  P
Sbjct:    4 CEKISIDLCRSVGYNVTRMPNLIGHETQKEAESQLKQFLPLIQYGCAREQLVFFLCSAYAPMCTDKVDVVITSCRPLCEYVRKSCLPVLTEFGIPWPNPLNCTRFLVRNNERNMCMPGPNFTESPEKPRPDFKPINDTTEKPPSTGSEQCRRFKNSKNYFYVQSTESCAVRCNEDGIFKTSDKETMDIWITIWSIFCFISTTITLTTFLIETGRFKYPERSIIWLALCYNFYSLSYIIRLGAGRQAISC-----DTDPTTHVKFHIQDGLRNTGCAIVFLIQYFFCMAATIWWVVLALTWFLAAGMKWGCEAIGSYAKLFHIIAWILPCIKTIFILITRKVDGDELTGLCFVGNQDLIALAAFVLGPQFTYLIIGTLFLIAGFVALFRIRTTVQRGGQAKTDKLERLIVRIGIFSVLSTVPATAVIACYFYEYAN----KEYWYY-------------------------GQRDGAVAEPNFSIFMLKVFMSLFTGVITGMWIWSHKTMNTWRAFYYKVSGKRPP 494          
BLAST of Fzd-1/2/7 vs. Ensembl Nematostella
Match: EDO40119 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S829])

HSP 1 Score: 179.489 bits (454), Expect = 1.502e-48
Identity = 147/530 (27.74%), Postives = 250/530 (47.17%), Query Frame = 3
Query:   72 FINNIRAVNDPYNQPN--CEKIKVPACQG--LLYQMTIFPNHMLHSTQDEAALEINEYVPLMRI-KCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMK-RFQYPERPIIFLSACYLVVGLTYVAGFFLN--DKVACAGPFTNKDSTGKTPKIVVQGTKFES--CIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWA-HESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKT--GGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            F   I + +  Y+Q +  CE +K   C G  L Y  T        S+QD+    + ++  L  + KC   LQ FLC +Y P C      LP CR  C   +K C  +  + Y +WP+ + CD  PE N     N T K+   N S +C   L +  +Y    + S    I+ CGI C    F+E    +  R +VA +  +    TLFTV+TFL+  K + +YP   + F++AC+ V  + ++  F  +   KV C      +D T +    + + T+ +S  C++ F+L+Y+FS+A   W+V+L  +W +  K   +  ++    + YFH  +W++PA  T  +L + +VD + ++G+CF G  +PS   GFL+APL + L+IG  FL  G  ++F++R           + K+++ I R+G F+ +      +  AC+ +E  N  +W + +    +C           I +H+ +    N      +    +  +        GI    W W+  T  +WK  + R+
Sbjct:    8 FCGIITSYSSAYSQGSYKCEPLKEQTCLGEKLDYHYTTTELVTDSSSQDQVKKNLEKWEGLKFLPKCWEVLQPFLCQIYKPKCKNGSVELP-CREQCFATRKPCSVV--ESYRRWPEFLRCDKLPEGNC----NGTLKKLHLNES-ACKAPL-VETAY----KPSWYEGIEGCGIQCMNPIFSEEEHTRIHR-FVAAFGTLTTVCTLFTVVTFLVGWKSQNRYPSVILFFMNACFCVASVGFLIQFSSDARRKVVC-----RRDDTMR----LGEPTESDSFLCVLTFVLVYYFSLAGMTWFVMLAYSWCICFKTLGSTRDNFAGKTGYFHIISWSLPAVLTGCVLLVKQVDANSISGICFVGYKNPSMRAGFLLAPLGLDLVIGGMFLAKGLFTLFKLRKSNPNFLSNRASIKIKETIMRVGFFAFVAFAFVFITFACHVYEYYNQERWERSYRAFLMC-----------IANHE-VKGVSNTCSIKDRANLSVLELSLSSLFGAGIAMSGWTWTSNTFKTWKKLWHRV 502          
BLAST of Fzd-1/2/7 vs. Ensembl Medaka
Match: fzd7b (frizzled class receptor 7b [Source:ZFIN;Acc:ZDB-GENE-990415-229])

HSP 1 Score: 492.656 bits (1267), Expect = 1.534e-166
Identity = 258/545 (47.34%), Postives = 352/545 (64.59%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENN---LCIRDNQTEKESA--------------PNV-------------SLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNR------YYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLNPGD 1646
            C+ I +P C  + Y  TI PN + H+ Q++A LE++++ PL++++C   L+ FLCS+Y PVCT++++A+PPCRSLC + ++ CE ++ KF F+WP+ + C+ +P N    +C+  N +E  S               PN                SCP  L++P    ++        ++DCG PC         YF E  + KF R+WV +WS +C  STLFTVLT+L+DM+RF+YPERPIIFLS CY +V + Y AGFFL DKV C   F      G+  + V QGTK E C ILFM+LYFF MAS+IWWV+L++TW+L+A   W HE+I  NSQYFH AAWA+PA KTI ILA+ +VDGD LTGVCF G+ +   LRGF++APL +YL IGT FL+AGFVS+F IRTI+K  G+KT+KLEKL+ RIG+FSVLY VPA +VIACYF+E      W + W++   C+   +   C  +H+  P+            P+F +FMIKYLM++IVGITSG W+WSGKTL SW+ F+ RL G  N G+
Sbjct:   30 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSTELKFFLCSMYAPVCTVLEQAIPPCRSLCERARQGCEALMNKFGFQWPERLHCEAFPVNGGSEICVGQNTSEPGSPSSSSPHVPELVTVPPNRFPNPPQPPHNSYHQFSCPLQLEVPSYLGYRFM-----GVKDCGAPCEPTKPSGIMYFREDEV-KFGRLWVGIWSILCCVSTLFTVLTYLVDMRRFRYPERPIIFLSGCYFMVAVAYAAGFFLEDKVVCVDKFK-----GEGFRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLSAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILAMGQVDGDVLTGVCFVGIFNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERTWHM-QTCK--RFAVPC-PVHNFAPMT-----------PDFTVFMIKYLMTMIVGITSGFWVWSGKTLQSWRRFYKRL-GNGNHGE 547          
BLAST of Fzd-1/2/7 vs. Ensembl Medaka
Match: fzd2 (frizzled class receptor 2 [Source:ZFIN;Acc:ZDB-GENE-990415-224])

HSP 1 Score: 475.322 bits (1222), Expect = 9.387e-160
Identity = 250/534 (46.82%), Postives = 345/534 (64.61%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP----ENNLCIRDNQTE-------------KESAPNVS-----LSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCN------RYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLN 1637
            C++I +P C  + Y  TI PN M +  Q++A LE++++ PL++++C   L+ FLCS+Y PVCT+++K +PPCR +C + ++ CE ++ KF F+WP+ + C+ +P       +C+  N++                  P VS      +CP  L++P   ++     +     DCG PC         +F++  +  FAR+WV +WS +C  ST FTV T+LIDM+RF+YPERPIIFLS CY +V + ++AG+FL DKVAC   F N D      K VVQGTK E C ILFM+LYFFSMAS+IWWV+L++TW+LAA   W HE+I  NSQYFH AAWA+PA KTI ILA+ +++GD L+GVCF  LS+   LRGF++APL IYL IGT FL+AGFVS+F IRTI+K  G+KT+KLE+L+ RIG+FSVLY VPA +VIAC+F+E      W + W   + CRS       +     +P             P+F ++MIKYLM+LIVGITSG WIWSGKTL SW+ F++RL    N
Sbjct:   35 CQQISIPLCTDIAYNQTIMPNLMGNHNQEDAGLEVHQFFPLVKVQCSPELKFFLCSMYAPVCTVLEKPIPPCRPICEKARQGCEALMNKFGFQWPEKLRCENFPLLGDHGQICVGQNESSSPTAPPPLPPAPGTRELPRVSTHERPFTCPSVLRVPPYLNYHFLEEK-----DCGAPCESPRNGGNMFFSDKEIH-FARMWVLIWSVLCCTSTFFTVTTYLIDMQRFRYPERPIIFLSGCYTMVSIAFIAGYFLGDKVACNDSF-NPDGY----KTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTISILAMGQIEGDVLSGVCFVSLSNLDPLRGFVLAPLFIYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEQLMVRIGVFSVLYTVPATIVIACFFYEQAFRPHWERSWVSRN-CRSLAIPCPAQS----RP----------HMTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTSGKN 542          
BLAST of Fzd-1/2/7 vs. Ensembl Medaka
Match: ENSORLT00000002667.2 (pep primary_assembly:ASM223467v1:17:316235:318512:1 gene:ENSORLG00000002147.2 transcript:ENSORLT00000002667.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 422.935 bits (1086), Expect = 4.321e-139
Identity = 235/552 (42.57%), Postives = 326/552 (59.06%), Query Frame = 3
Query:  117 NCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVC-TIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPE----NNLCIRDNQTEKESAPNVSLSCPKSLQ----------------------------------IPVSYDF-----KIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFL-NDKVAC----AGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLC 1625
             C++I VP C+G+ Y  T  PN   H TQDEA LE++++ PL+ IKC   L+ FLCS+Y P+C    KK LPPCR +C + K  C P+++++ F WP  M CDL PE    ++LC+  +      +P ++    + L+                                  +PVS +      ++R  Q   I +C +PC   YF +   R F   W+ LWS +C  ST  TV TFLIDM+RF+YPERPIIFLSACY+ V + Y+      +++VAC       + + ++TG  P +         C I+F+L+YFF MAS+IWWV+L++TW+LAA   W +E+IG  SQ+FH AAW IP+ K+I +LALS VDGD + GVC+ G  +  +LRGF++APL IYL+IGT FL+AGFVS+F IR++IK GG+KTDKLE+LI RIG+F+VLY VPA V++ACYF+E  N     Q W +   C  A    +                    Q+P + +FM+KY M L+VGITSG WIWSGKTL +W+ F  R C
Sbjct:   23 QCQEISVPLCKGIGYNYTHMPNKFHHDTQDEAGLEVHQFWPLVEIKCSPDLRFFLCSMYTPICLEDYKKPLPPCRGVCERAKAGCAPLMRQYGFPWPDRMRCDLLPEQGNHDSLCMDYSSQTTTVSPALAKPTNRPLKPYNKRKGPYGRTFPGKHKPAGSPCEAACSCRAPMVPVSSEGHPLHNRVRTGQ---IVNCAVPCYNPYFTQEE-RTFTSFWIGLWSILCFISTFTTVATFLIDMERFKYPERPIIFLSACYMFVSVGYIVRLVAGHEEVACNMWNGAGYIHYETTG--PAL---------CTIVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIGSYSQHFHLAAWLIPSMKSIAVLALSSVDGDSVAGVCYVGNQNLDSLRGFVLAPLVIYLVIGTMFLLAGFVSLFRIRSVIKQGGTKTDKLERLIIRIGVFTVLYTVPATVIVACYFYEQHN----RQAWEITHNCTCATEPSK--------------------QRPNYAVFMLKYFMCLLVGITSGAWIWSGKTLDTWRTFCRRCC 535          
BLAST of Fzd-1/2/7 vs. Ensembl Medaka
Match: fzd8a (frizzled class receptor 8a [Source:ZFIN;Acc:ZDB-GENE-000328-3])

HSP 1 Score: 422.165 bits (1084), Expect = 8.237e-139
Identity = 236/544 (43.38%), Postives = 322/544 (59.19%), Query Frame = 3
Query:  117 NCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVC-TIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP----ENNLCIRDNQTEKESAP-------NVSLSCPKS------------------------LQIPVSYDFKIRLSQNSV----IQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFL-NDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLC 1625
             C+ I VP C+G+ Y  T  PN   H TQDEA LE++++ PL+ I+C   L+ FLCS+Y P+C    KK LPPCRS+C + +  C P+++++ F WP  M CDL P     + LC+  N+ +  +A        N     PKS                        L+  V+   +     N V    + +C +PC+  YF   + R F   W+ LWS +C  ST  TV TFLIDM+RF+YPERPIIFLSACY+ V + Y+      ++KVAC     N+D       I  + T    C I+F+L+YFF MAS+IWWV+L++TW+LAA   W +E+I   +Q+FH AAW IP+ K+I +LALS VDGD + G+C+ G  +   LRGF++APL IYL IGT FL+AGFVS+F IR++IK GG+KTDKLEKL+ RIGIF+VLY VPA V++ACYF+E  N     Q W +   C S   + E  +                   P++ +FM+KY M L+VGITSG+WIWSGKTL SW+ F +R C
Sbjct:   20 TCQGIAVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERARAGCAPLMRQYGFPWPDRMRCDLLPVQGNPDTLCMDYNRNDSTTASPVLSKPTNHPGRSPKSKPGRAGAPGKYKPPAAPCEPGCRCLEPMVAVTTERHPLYNRVKTGQVTNCAMPCHNPYFTH-DERAFTAFWIGLWSVLCFVSTFATVATFLIDMERFKYPERPIIFLSACYMFVSVGYIVRLIAGHEKVAC-----NRDF--DVEHIHYETTGPALCTIVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYAQHFHLAAWLIPSMKSIAVLALSSVDGDSVAGICYVGNQNLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTVLYTVPATVIVACYFYEQHN----RQDWEMTHNCSSCLMERERAR-----------------SGPDYAVFMLKYFMCLLVGITSGVWIWSGKTLDSWRTFCTRCC 534          
BLAST of Fzd-1/2/7 vs. Ensembl Medaka
Match: ENSORLT00000013002.2 (pep primary_assembly:ASM223467v1:21:5638676:5644296:-1 gene:ENSORLG00000010376.2 transcript:ENSORLT00000013002.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 420.624 bits (1080), Expect = 2.279e-138
Identity = 235/529 (44.42%), Postives = 318/529 (60.11%), Query Frame = 3
Query:  120 CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVC-TIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPE---NNLCIRDNQTEKE-SAPNVSLSCPKSLQIPVS---YDFKIRLS-----------------QNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFL-NDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECK-KIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLC 1625
            CE I VP C+G+ Y +T  PN   H TQ+E  LE++++ PL+RI+C   L  FLCS+Y P+C    +K LPPCRS+C + K+ C P++ ++ F+WP+ MSC+  P+     LC+  N +E   SAP    S PK    P S    D + R                   Q   + +C +PC+  YF+  + R F   WV LWS +C  STL TV TFLIDM+RF+YPERPIIFL+ACYL V L Y+      +++VAC    T++        I+   T    C ++F+L+YFF MAS+IWWVVL+ TW+LAA   W  E+I   SQYFH AAW IP+ K+I +LALS VDGDP+ G+C+ G      LRGF++APL +YL  GT FL+AGFVS+F IR+IIK GG+KTDKLE+L+ RIG+F+VLY VPA +V+AC  +E      W             E    C   +   + I          + P++ +FM+KY M L+VGITSG+WIWSGKTL SW+ F +R C
Sbjct:   24 CEPITVPMCKGIGYNLTYMPNKFNHDTQEEVGLEVHQFWPLVRIRCSPDLLFFLCSMYTPICLPDYRKPLPPCRSVCERAKRGCSPLMSQYGFEWPERMSCEGLPQLGDETLCMDQNSSEATTSAPPFPKSTPKVRTRPPSPSQCDRECRCRDPLIPIKRESHALFGRVQTGPLPNCALPCHLPYFSA-DERAFTSFWVGLWSVLCFISTLTTVATFLIDMERFKYPERPIIFLAACYLFVSLGYIIRLVAGHERVACGAGGTSQL------HILYDATGPALCTLVFLLVYFFGMASSIWWVVLSFTWFLAAGMKWGSEAIAGYSQYFHLAAWLIPSVKSILVLALSSVDGDPVAGICYVGNQSLENLRGFVLAPLVVYLFTGTLFLLAGFVSLFRIRSIIKQGGTKTDKLERLMIRIGLFTVLYTVPATIVVACLVYEQHYRPSW-------------ERALACSCPLERQRSI----------RGPDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWRSFVARCC 522          
BLAST of Fzd-1/2/7 vs. Planmine SMEST
Match: SMESG000040115.1 (SMESG000040115.1)

HSP 1 Score: 1159.05 bits (2997), Expect = 0.000e+0
Identity = 592/592 (100.00%), Postives = 592/592 (100.00%), Query Frame = 3
Query:  165 MTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLNPGDPWTRSDWLEKNNGYYQRHFVGPTANKMIIQGCDDKQAIPLXXXXXXXXXXXXXXXXXXKPLLSNVPESILNAQAQNGNLLPPSQQIGDSKTQKIGFMM 1940
            MTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSVLYVVPAVVVIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLNPGDPWTRSDWLEKNNGYYQRHFVGPTANKMIIQGCDDKQAIPLQYQFPQQTQQTIGTQELQKPLLSNVPESILNAQAQNGNLLPPSQQIGDSKTQKIGFMM
Sbjct:    1 MTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSVLYVVPAVVVIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLNPGDPWTRSDWLEKNNGYYQRHFVGPTANKMIIQGCDDKQAIPLQYQFPQQTQQTIGTQELQKPLLSNVPESILNAQAQNGNLLPPSQQIGDSKTQKIGFMM 592          
BLAST of Fzd-1/2/7 vs. Planmine SMEST
Match: SMESG000040115.1 (SMESG000040115.1)

HSP 1 Score: 1143.26 bits (2956), Expect = 0.000e+0
Identity = 585/585 (100.00%), Postives = 585/585 (100.00%), Query Frame = 3
Query:  186 MLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLNPGDPWTRSDWLEKNNGYYQRHFVGPTANKMIIQGCDDKQAIPLXXXXXXXXXXXXXXXXXXKPLLSNVPESILNAQAQNGNLLPPSQQIGDSKTQKIGFMM 1940
            MLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSVLYVVPAVVVIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLNPGDPWTRSDWLEKNNGYYQRHFVGPTANKMIIQGCDDKQAIPLQYQFPQQTQQTIGTQELQKPLLSNVPESILNAQAQNGNLLPPSQQIGDSKTQKIGFMM
Sbjct:    1 MLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGGSKTDKLEKLITRIGIFSVLYVVPAVVVIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLNPGDPWTRSDWLEKNNGYYQRHFVGPTANKMIIQGCDDKQAIPLQYQFPQQTQQTIGTQELQKPLLSNVPESILNAQAQNGNLLPPSQQIGDSKTQKIGFMM 585          
BLAST of Fzd-1/2/7 vs. Planmine SMEST
Match: SMESG000005043.1 (SMESG000005043.1)

HSP 1 Score: 370.163 bits (949), Expect = 3.295e-118
Identity = 217/531 (40.87%), Postives = 304/531 (57.25%), Query Frame = 3
Query:   87 RAVNDPYNQPN-----CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIM-KKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESAPNVSLSCPKSLQIPVSYDFKIRLSQNSVIQ----DCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDK-VACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGG-SKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL----CGR 1631
            RA  D  NQ N     C  I +P C+ + Y +T  PN   H TQ+EA L ++++ PL+ I C  +L+LFLCSLY P+C     K +  CRS+C   +  C P++  + FKWP+SM CD   EN  C++ +       P  S  C    + P  YD K +   NSVI     +C   C+   F   + + F   W+ LW+ +C  S+  TVLTFL+D  RF+YPERPI+FLS CY++V + Y+    +  + +AC G      +TG              C I+F+L+YFF MA+++WWV+LTITW+L+A   W  E+I + S+ FHF AW +   K+I  L L  +DGDP+ G+C+ G ++   L+ FLI PL +YLLIG+ FL++GF+++  IR  I+  G SKTDKLEKL+ RIGIF +LY VPA VVI C+ +E  N   W             E  + C   + ++ I    N   FS KPE+ +FM+KY M L+VGITSG WIW+ KTL SW   F RL    CG+
Sbjct:   43 RASADRSNQENFRPNKCVPIAIPMCKNIGYNLTYMPNEFHHETQEEAGLVVHQFYPLVEIACSDNLRLFLCSLYAPICLPNWPKPIQACRSVCESARDGCAPVMNTYGFKWPKSMDCDKLTENQACLKKDTKNVTKPP--SKGCECKCRSPYIYDNKPQF--NSVITGGVANCFQSCHSANFVSID-KSFVTFWLGLWAVLCCLSSTATVLTFLLDRSRFKYPERPIVFLSGCYMMVSIGYIIRVAVGHELIACDGDKLRYGTTGPA-----------RCSIVFLLIYFFGMAASVWWVILTITWFLSAGLKWGSEAISKYSEIFHFLAWFLSGVKSILALTLVAIDGDPVGGICYIGNTNSLNLKLFLIVPLTVYLLIGSCFLLSGFIALISIRKTIRAKGESKTDKLEKLMMRIGIFGLLYSVPAAVVIGCHLYEVKNREFW-------------EKSNNC---YCNRNIKSQEN---FS-KPEYSVFMLKYFMCLVVGITSGFWIWTSKTLDSWHNAFRRLSQSICGQ 537          
BLAST of Fzd-1/2/7 vs. Planmine SMEST
Match: SMESG000035834.1 (SMESG000035834.1)

HSP 1 Score: 368.622 bits (945), Expect = 3.664e-116
Identity = 215/562 (38.26%), Postives = 312/562 (55.52%), Query Frame = 3
Query:   84 IRAVNDPYNQPNCEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMK-KALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYP-----ENNLCIRDN-QTEKESAPNVSLSCPK------SLQIP-------VSYDFKIRLSQNSVIQ---------------------------DCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIK--TGGSKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            +++ N   ++  CE IK+P C+ + Y MT+ PN   H  QDEA  E +++ PL++IKC   LQ FLCS+Y P+C     K+LPPCRS+C ++KK C+P+L+K+ FKWP+ M+CD +P     E  LC+  N  T   +  +V    PK      S Q+        VSY    + +     Q                           +C   C   +F+  + +KF   W+ LW+ +C+ ST   V TF ID  R++YPERPIIF+S CY +V L ++    +  +         KD +  +  +   G+    C I+F+L+Y+F MA+++WWV+LTITW+LAA   W  E+I + SQ +HF AW +P  K+I  L +S VDGDP++G+C+ G +    L  F+++PL +YL IGT  LI+GF S+F IR+IIK  TGG KT+KLEKL+ RIG+FSVLY  PA V++AC  +E  N  +W Q               +C   + H+   P         +P + +FM KY M + VG+TSG WIWS KT+LSWK    RL
Sbjct:   31 LKSDNTNRDKGKCEIIKIPMCKDIHYNMTMMPNMFNHENQDEAGFEAHQFYPLVQIKCSEDLQFFLCSIYTPICLKQYVKSLPPCRSVCERVKKGCDPLLQKYTFKWPEKMNCDQFPVYNNPEKILCMEKNLSTASTTLASVVTLAPKEQNDANSRQVAEQNLLNEVSYQLTRQYNSRVFCQCSCRKPLIDIAEINKAHFNRVSTLGMFNCAQGCKSPFFSSESDQKFIGFWLGLWTIICLLSTFSIVATFSIDPGRYRYPERPIIFMSICYFMVSLGFLIRIVMGHEDLACDSIKAKDGSSLS-LLRYGGSGPAHCTIVFLLIYYFGMAASLWWVLLTITWFLAAGLKWGSEAISKYSQIYHFLAWFLPGIKSIVALTMSAVDGDPVSGICYVGNTSDFNLILFVLSPLLVYLTIGTLVLISGFASLFRIRSIIKLQTGG-KTEKLEKLMIRIGVFSVLYTAPAAVIVACIIYELQNRAEWYQ-----------NLSCDCFDSNRHQLNLP---------RPSYSVFMFKYFMFMGVGMTSGFWIWSKKTILSWKMVCYRL 570          
BLAST of Fzd-1/2/7 vs. Planmine SMEST
Match: SMESG000031852.1 (SMESG000031852.1)

HSP 1 Score: 360.918 bits (925), Expect = 4.179e-115
Identity = 205/527 (38.90%), Postives = 305/527 (57.87%), Query Frame = 3
Query:   90 AVNDPYNQPN-CEKIKVPACQGLLYQMTIFPNHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTI-MKKALPPCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIR-DNQTEKESAPNV---------SLSCPKSLQIPVSYDFKIRLSQ--NSVIQDCGIPCNRYYFNEPNLRKFARVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTYVAGFFL-NDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSMASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILALSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMFEIRTIIKTGG-SKTDKLEKLITRIGIFSXXXXXXXXXXIACYFHESMNLYKWMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIKYLMSLIVGITSGIWIWSGKTLLSWKYFFSRL 1622
            +++ P  +P+ C  I++  C+G+ Y +T  PN + H++ +EA LEI ++  L+ I C   L+LFLCS+Y P+C       +P CRSLC+  ++ C  ++ ++ FKWP+ M+C+  PE+N C+R DN+T      N          S  C    + P+  D +   ++     I +C + C   YF E + + F+  W+ +W+ +C+ ST  T+LTF ID  RFQYPERPIIFLS CYL++ + Y+    L ++ VAC        S+G  P           C I+F+ +YFF MAS+IWWVVLT TW+LAA   W  E+I   +  +HF AW IP  ++I IL +S VDGDP++G+C+ G  +   L  F+I PL +YLL+GTGFL+AGF+++ +IR  IK  G SKTDKLEKL+ RI IF ++Y VP + V+ C  +E +    W Q +     CR+ +Y                        +PE+ +FM+KY M+L+VG T+G WIW+ KTL SW   F +L
Sbjct:   24 SISKPDLRPSTCIPIEISMCKGIGYNLTYIPNDLNHASLEEAGLEIQQFNALVEINCSEDLRLFLCSMYAPICLPNWPNRIPACRSLCISAREGCTRVMNQYGFKWPEGMNCEKLPEDNACLRKDNKTRSNKTANFVSERPYLLKSKKCHCHCRSPLIIDSRDHFNKVVTGNISNCLMNCRSPYFGEFD-KSFSTFWLGIWACVCIISTSVTILTFCIDKSRFQYPERPIIFLSICYLLMSVGYLIRVALGHEAVACKSDAIRYGSSGAVP-----------CSIVFLFIYFFGMASSIWWVVLTATWFLAAGLKWGSEAILMYADIYHFFAWFIPGIQSIIILTMSSVDGDPVSGICYVGNLNKYNLLFFVIIPLIVYLLVGTGFLLAGFLALMKIRKTIKEKGESKTDKLEKLMIRISIFGIVYSVPTMTVVFCSIYEFIFRDLWEQSYTC--PCRTKKY------------------------QPEYSVFMLKYFMNLVVGTTAGFWIWTPKTLDSWSKVFCKL 512          
The following BLAST results are available for this feature:
BLAST of Fzd-1/2/7 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
FZD11.328e-16847.30frizzled class receptor 1 [Source:HGNC Symbol;Acc:... [more]
FZD71.899e-16446.49frizzled class receptor 7 [Source:HGNC Symbol;Acc:... [more]
FZD22.776e-15945.30frizzled class receptor 2 [Source:HGNC Symbol;Acc:... [more]
FZD52.981e-13842.36frizzled class receptor 5 [Source:HGNC Symbol;Acc:... [more]
FZD101.709e-12842.59frizzled class receptor 10 [Source:HGNC Symbol;Acc... [more]
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BLAST of Fzd-1/2/7 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mom-56.773e-10333.99pep chromosome:WBcel235:I:9965580:9969413:1 gene:W... [more]
mom-51.059e-10233.87pep chromosome:WBcel235:I:9965580:9970037:1 gene:W... [more]
cfz-21.384e-8530.10Frizzled-2 [Source:UniProtKB/Swiss-Prot;Acc:G5ECQ... [more]
lin-178.403e-7630.70Transmembrane receptor LIN-17 [Source:UniProtKB/T... [more]
lin-178.403e-7630.70Transmembrane receptor LIN-17 [Source:UniProtKB/T... [more]
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BLAST of Fzd-1/2/7 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fz3.388e-14643.22gene:FBgn0001085 transcript:FBtr0075743[more]
fz6.470e-14643.22gene:FBgn0001085 transcript:FBtr0330102[more]
fz21.898e-9943.26gene:FBgn0016797 transcript:FBtr0112890[more]
fz21.898e-9943.26gene:FBgn0016797 transcript:FBtr0075029[more]
fz21.898e-9943.26gene:FBgn0016797 transcript:FBtr0332735[more]
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BLAST of Fzd-1/2/7 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fzd11.541e-17150.00frizzled class receptor 1 [Source:ZFIN;Acc:ZDB-GEN... [more]
fzd7a1.385e-16845.71frizzled class receptor 7a [Source:ZFIN;Acc:ZDB-GE... [more]
fzd7a1.385e-16845.71frizzled class receptor 7a [Source:ZFIN;Acc:ZDB-GE... [more]
fzd21.532e-16847.63frizzled class receptor 2 [Source:ZFIN;Acc:ZDB-GEN... [more]
fzd7b1.426e-16547.36frizzled class receptor 7b [Source:ZFIN;Acc:ZDB-GE... [more]
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BLAST of Fzd-1/2/7 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ntrk17.319e-16446.50neurotrophic receptor tyrosine kinase 1 [Source:Xe... [more]
bdh24.243e-16346.503-hydroxybutyrate dehydrogenase 2 [Source:Xenbase;... [more]
zdhhc96.191e-14343.82zinc finger DHHC-type containing 9 [Source:Xenbase... [more]
fzd83.695e-13943.14frizzled class receptor 8 [Source:NCBI gene;Acc:10... [more]
FZD95.847e-12941.43frizzled class receptor 9 [Source:NCBI gene;Acc:10... [more]
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BLAST of Fzd-1/2/7 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Fzd13.676e-16847.12frizzled class receptor 1 [Source:MGI Symbol;Acc:M... [more]
Fzd71.108e-16447.04frizzled class receptor 7 [Source:MGI Symbol;Acc:M... [more]
Fzd27.070e-16045.30frizzled class receptor 2 [Source:MGI Symbol;Acc:M... [more]
Fzd53.411e-13942.83frizzled class receptor 5 [Source:MGI Symbol;Acc:M... [more]
Fzd53.411e-13942.83frizzled class receptor 5 [Source:MGI Symbol;Acc:M... [more]
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BLAST of Fzd-1/2/7 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9I9M5|FZD1_XENLA1.795e-16948.89Frizzled-1 OS=Xenopus laevis OX=8355 GN=fzd1 PE=1 ... [more]
sp|O57328|FZD1_CHICK8.965e-16947.64Frizzled-1 OS=Gallus gallus OX=9031 GN=FZD1 PE=2 S... [more]
sp|Q9UP38|FZD1_HUMAN6.378e-16847.30Frizzled-1 OS=Homo sapiens OX=9606 GN=FZD1 PE=1 SV... [more]
sp|O70421|FZD1_MOUSE2.571e-16747.12Frizzled-1 OS=Mus musculus OX=10090 GN=Fzd1 PE=1 S... [more]
sp|Q08463|FZD1_RAT5.786e-16547.12Frizzled-1 OS=Rattus norvegicus OX=10116 GN=Fzd1 P... [more]
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BLAST of Fzd-1/2/7 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
T1E1C60.000e+0100.00Fzd-1/2/7 OS=Schmidtea mediterranea OX=79327 PE=2 ... [more]
T1E1120.000e+077.71Fzd-1/2/7 OS=Dendrocoelum lacteum OX=27895 PE=2 SV... [more]
A0A3Q0KT770.000e+061.48Putative frizzled OS=Schistosoma mansoni OX=6183 P... [more]
A0A075FFK00.000e+061.71Frizzled-like protein OS=Schistosoma mansoni OX=61... [more]
C6ZDD00.000e+060.58Frizzled 7 OS=Schistosoma japonicum OX=6182 PE=2 S... [more]
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BLAST of Fzd-1/2/7 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fzd7b1.869e-16647.64frizzled class receptor 7b [Source:ZFIN;Acc:ZDB-GE... [more]
FZD71.085e-16246.22frizzled-7-A-like [Source:NCBI gene;Acc:103021589][more]
ENSAMXT00000026985.21.486e-13942.78pep primary_assembly:Astyanax_mexicanus-2.0:19:270... [more]
fzd9a2.036e-12641.04frizzled class receptor 9a [Source:ZFIN;Acc:ZDB-GE... [more]
fzd8a1.833e-12441.11frizzled class receptor 8a [Source:ZFIN;Acc:ZDB-GE... [more]
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BLAST of Fzd-1/2/7 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fzd21.641e-16646.76frizzled class receptor 2 [Source:ZFIN;Acc:ZDB-GEN... [more]
fzd7a1.152e-16546.35frizzled class receptor 7a [Source:ZFIN;Acc:ZDB-GE... [more]
ENSPMAT00000011009.11.565e-13040.62pep scaffold:Pmarinus_7.0:GL485859:2701:4509:1 gen... [more]
fzd8a3.621e-8941.93frizzled class receptor 8a [Source:ZFIN;Acc:ZDB-GE... [more]
fzd3b1.232e-6740.80frizzled class receptor 3b [Source:ZFIN;Acc:ZDB-GE... [more]
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BLAST of Fzd-1/2/7 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Fzd-1/2/7 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO357515.963e-16547.44Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO429321.941e-12740.11Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO385674.679e-11739.25Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO308659.880e-9836.76Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO401191.502e-4827.74Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Fzd-1/2/7 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fzd7b1.534e-16647.34frizzled class receptor 7b [Source:ZFIN;Acc:ZDB-GE... [more]
fzd29.387e-16046.82frizzled class receptor 2 [Source:ZFIN;Acc:ZDB-GEN... [more]
ENSORLT00000002667.24.321e-13942.57pep primary_assembly:ASM223467v1:17:316235:318512:... [more]
fzd8a8.237e-13943.38frizzled class receptor 8a [Source:ZFIN;Acc:ZDB-GE... [more]
ENSORLT00000013002.22.279e-13844.42pep primary_assembly:ASM223467v1:21:5638676:564429... [more]
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BLAST of Fzd-1/2/7 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000040115.10.000e+0100.00SMESG000040115.1[more]
SMESG000040115.10.000e+0100.00SMESG000040115.1[more]
SMESG000005043.13.295e-11840.87SMESG000005043.1[more]
SMESG000035834.13.664e-11638.26SMESG000035834.1[more]
SMESG000031852.14.179e-11538.90SMESG000031852.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30025215 ID=SMED30025215|Name=Fzd-1/2/7|organism=Schmidtea mediterranea sexual|type=transcript|length=2307bp
TATAACAAACAACATAATTAGCGATTAATATGTTAATCAAATATTTTTTA
ATAGTCTCTTTTGTTTTTTTGTTTATTAATAATATTCGTGCCGTTAATGA
CCCATATAATCAGCCAAACTGTGAAAAAATCAAGGTACCGGCATGTCAGG
GTTTATTATATCAAATGACAATTTTTCCAAACCACATGCTGCATTCAACG
CAAGACGAAGCAGCTCTCGAAATCAATGAATATGTTCCATTAATGAGAAT
AAAATGTCATGGATCCTTACAGCTGTTTCTCTGCTCTCTCTATTTTCCTG
TTTGTACTATCATGAAAAAAGCACTTCCACCTTGCCGTTCCCTATGCTTA
CAAATTAAAAAGGAATGTGAACCAATATTAAAAAAGTTTTACTTTAAATG
GCCACAGTCAATGTCTTGTGATCTCTATCCTGAAAATAATCTTTGTATTC
GAGATAATCAGACTGAGAAAGAAAGTGCACCAAATGTTTCTTTATCATGT
CCAAAGTCTTTACAGATTCCAGTTAGCTATGATTTTAAAATCAGATTATC
ACAGAATTCCGTTATCCAAGACTGTGGAATTCCATGTAATCGATATTATT
TCAATGAGCCAAATTTAAGAAAATTTGCTCGGGTTTGGGTTGCGTTGTGG
AGTTTCATGTGTGTTGGATCAACTTTATTTACTGTTCTAACATTTCTAAT
CGACATGAAACGTTTTCAATATCCAGAACGGCCAATCATTTTTTTATCAG
CTTGCTATTTAGTTGTTGGTCTTACTTACGTTGCTGGATTCTTTCTAAAC
GACAAAGTAGCTTGTGCGGGTCCTTTCACTAATAAAGACTCTACTGGGAA
AACTCCGAAAATAGTTGTGCAGGGTACCAAATTCGAAAGCTGTATTATTC
TTTTTATGTTACTTTACTTCTTTTCAATGGCCAGCGCTATTTGGTGGGTT
GTACTTACTATTACTTGGTATCTTGCTGCCAAGTGCCACTGGGCTCACGA
GTCTATCGGGAGAAATTCACAATACTTTCATTTTGCTGCTTGGGCAATTC
CTGCCGGTAAAACTATAGGTATTTTAGCTCTAAGTAAAGTTGACGGAGAT
CCTCTTACTGGGGTTTGTTTTACTGGATTAAGTGATCCATCAACACTTAG
AGGATTTCTAATAGCTCCTCTCTGTATATATTTGCTAATTGGTACCGGAT
TTCTGATAGCTGGATTCGTTTCGATGTTTGAAATTCGAACTATTATCAAA
ACTGGAGGTTCGAAAACCGATAAATTAGAAAAACTAATTACTCGAATCGG
GATCTTTAGTGTACTTTATGTAGTGCCGGCCGTGGTTGTTATCGCATGTT
ATTTTCATGAATCGATGAATCTTTATAAATGGATGCAACGTTGGTATTTA
ATTGACATTTGCCGATCAGCAGAATACAAAGATGAATGTAAGAAAATTCA
CGATCATAAACCAATCAATCCTGGTGGAAATGCCTTAATTTTTTCTCAGA
AGCCTGAATTTGAGCTTTTTATGATTAAATATTTAATGAGTTTAATAGTT
GGAATCACGAGTGGAATTTGGATTTGGAGTGGGAAAACTTTGTTGTCATG
GAAGTATTTCTTTTCGAGATTATGTGGCCGTTTGAATCCTGGAGATCCAT
GGACAAGATCGGATTGGTTGGAAAAGAACAATGGTTATTACCAAAGACAT
TTTGTTGGGCCTACGGCAAATAAAATGATCATCCAAGGCTGTGATGATAA
ACAGGCTATTCCATTACAGTATCAATTTCCACAACAAACTCAGCAGACAA
TTGGTACACAAGAACTGCAGAAACCATTACTGTCAAATGTTCCTGAAAGT
ATCTTAAACGCTCAAGCACAAAATGGAAATTTGTTACCTCCATCACAACA
AATAGGAGATTCTAAGACTCAGAAAATAGGTTTTATGATGTAAACTTTGA
AAATTATGTGAAACATACTGCTAATGGACCTCAACTGTTTTTACGCCAAA
TTTCGACAGTGATTTTACCATTTGATTATGATTCTTGCTGCTGTAGAACT
TCAGTTTTTTTTTCATTCAGTATTTATGCATTTAATTTAATATTTATTGT
AGAAAGTATTTTGGATTAGAAAACATTTAACTATCCAATTGTATTATATT
CATGAAAGTTGAACATTGCATGTCTTTTATGTTTATTTATTTTGTACATA
TTTTTATTCAGATTATTGCAAGTAAAAACTTGTCTTGGTTTATAAAAATT
GTAACGGAACAAATGTATTTTGAAATTCATTTCTTAATAGAACATTTATA
TGAAAGG
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protein sequence of SMED30025215-orf-1

>SMED30025215-orf-1 ID=SMED30025215-orf-1|Name=SMED30025215-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=638bp
MLIKYFLIVSFVFLFINNIRAVNDPYNQPNCEKIKVPACQGLLYQMTIFP
NHMLHSTQDEAALEINEYVPLMRIKCHGSLQLFLCSLYFPVCTIMKKALP
PCRSLCLQIKKECEPILKKFYFKWPQSMSCDLYPENNLCIRDNQTEKESA
PNVSLSCPKSLQIPVSYDFKIRLSQNSVIQDCGIPCNRYYFNEPNLRKFA
RVWVALWSFMCVGSTLFTVLTFLIDMKRFQYPERPIIFLSACYLVVGLTY
VAGFFLNDKVACAGPFTNKDSTGKTPKIVVQGTKFESCIILFMLLYFFSM
ASAIWWVVLTITWYLAAKCHWAHESIGRNSQYFHFAAWAIPAGKTIGILA
LSKVDGDPLTGVCFTGLSDPSTLRGFLIAPLCIYLLIGTGFLIAGFVSMF
EIRTIIKTGGSKTDKLEKLITRIGIFSVLYVVPAVVVIACYFHESMNLYK
WMQRWYLIDICRSAEYKDECKKIHDHKPINPGGNALIFSQKPEFELFMIK
YLMSLIVGITSGIWIWSGKTLLSWKYFFSRLCGRLNPGDPWTRSDWLEKN
NGYYQRHFVGPTANKMIIQGCDDKQAIPLQYQFPQQTQQTIGTQELQKPL
LSNVPESILNAQAQNGNLLPPSQQIGDSKTQKIGFMM*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000034epidermis
PLANA:0000044cephalic ganglia
PLANA:0000101muscle cell
PLANA:0000103central nervous system
PLANA:0000136whole organism
PLANA:0000418head
PLANA:0000420parapharyngeal region
PLANA:0000421tail
PLANA:0002074pharynx tip
PLANA:0007561head margin
Vocabulary: INTERPRO
TermDefinition
IPR036790Frizzled_dom_sf
IPR015526Frizzled/SFRP
IPR026548FZD1
IPR000539Frizzled/Smoothened_TM
IPR020067Frizzled_dom
IPR017981GPCR_2-like
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: biological process
TermDefinition
GO:0007166cell surface receptor signaling pathway
GO:0007275multicellular organism development
GO:0016055Wnt signaling pathway
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0004888transmembrane signaling receptor activity
GO:0042813Wnt-activated receptor activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000539Frizzled/Smoothened, transmembrane domainPRINTSPR00489FRIZZLEDcoord: 290..314
score: 62.56
coord: 496..516
score: 59.43
coord: 378..400
score: 55.65
coord: 419..440
score: 58.0
coord: 203..225
score: 55.13
coord: 231..253
score: 57.74
coord: 333..356
score: 58.5
IPR000539Frizzled/Smoothened, transmembrane domainSMARTSM01330Frizzled_2coord: 189..534
e-value: 1.1E-183
score: 626.2
IPR000539Frizzled/Smoothened, transmembrane domainPFAMPF01534Frizzledcoord: 195..530
e-value: 1.9E-128
score: 428.1
IPR020067Frizzled domainSMARTSM00063FRI_4coord: 30..144
e-value: 2.8E-47
score: 173.1
IPR020067Frizzled domainPFAMPF01392Fzcoord: 31..137
e-value: 3.2E-28
score: 98.6
IPR020067Frizzled domainPROSITEPS50038FZcoord: 26..142
score: 25.497
IPR036790Frizzled cysteine-rich domain superfamilyGENE3DG3DSA:1.10.2000.10coord: 24..146
e-value: 1.5E-36
score: 127.4
IPR036790Frizzled cysteine-rich domain superfamilySUPERFAMILYSSF63501Frizzled cysteine-rich domaincoord: 30..137
NoneNo IPR availableGENE3DG3DSA:1.20.1070.10coord: 157..534
e-value: 2.5E-127
score: 426.5
NoneNo IPR availableCDDcd150347tmF_FZD1_2_7-likecoord: 189..529
e-value: 0.0
score: 517.278
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..21
score: 0.85
NoneNo IPR availableTMHMMTMhelixcoord: 237..256
NoneNo IPR availableTMHMMTMhelixcoord: 419..441
NoneNo IPR availableTMHMMTMhelixcoord: 202..224
NoneNo IPR availableTMHMMTMhelixcoord: 496..518
NoneNo IPR availableTMHMMTMhelixcoord: 332..351
NoneNo IPR availableTMHMMTMhelixcoord: 289..311
NoneNo IPR availableTMHMMTMhelixcoord: 376..398
IPR015526Frizzled/secreted frizzled-related proteinPANTHERPTHR11309FRIZZLEDcoord: 28..149
coord: 153..532
IPR026548Frizzled-1PANTHERPTHR11309:SF81FRIZZLED-1coord: 28..149
coord: 153..532
IPR017981GPCR, family 2-likePROSITEPS50261G_PROTEIN_RECEP_F2_4coord: 200..523
score: 33.59