Peptidase S59 domain-containing protein

Overview
NamePeptidase S59 domain-containing protein
Smed IDSMED30024965
Length (bp)1814
Neoblast Clusters

Zeng et. al., 2018




 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Homology
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Human
Match: NUP98 (nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068])

HSP 1 Score: 110.538 bits (275), Expect = 1.835e-24
Identity = 59/163 (36.20%), Postives = 93/163 (57.06%), Query Frame = 2
Query: 1316 DDQSVEYDS--IISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            D + +E +S  +  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E VVY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  718 DREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 880          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Human
Match: NUP98 (nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068])

HSP 1 Score: 110.153 bits (274), Expect = 1.923e-24
Identity = 59/163 (36.20%), Postives = 93/163 (57.06%), Query Frame = 2
Query: 1316 DDQSVEYDS--IISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            D + +E +S  +  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E VVY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  701 DREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 863          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Human
Match: NUP98 (nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068])

HSP 1 Score: 110.153 bits (274), Expect = 2.646e-24
Identity = 59/163 (36.20%), Postives = 93/163 (57.06%), Query Frame = 2
Query: 1316 DDQSVEYDS--IISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            D + +E +S  +  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E VVY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  701 DREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 863          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Human
Match: NUP98 (nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068])

HSP 1 Score: 110.153 bits (274), Expect = 3.001e-24
Identity = 59/163 (36.20%), Postives = 93/163 (57.06%), Query Frame = 2
Query: 1316 DDQSVEYDS--IISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            D + +E +S  +  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E VVY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  718 DREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 880          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Human
Match: NUP98 (nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068])

HSP 1 Score: 110.153 bits (274), Expect = 3.283e-24
Identity = 59/163 (36.20%), Postives = 93/163 (57.06%), Query Frame = 2
Query: 1316 DDQSVEYDS--IISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            D + +E +S  +  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E VVY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  701 DREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 863          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Celegans
Match: npp-10 (Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex protein Nup98 Nuclear pore complex protein Nup96 [Source:UniProtKB/Swiss-Prot;Acc:G5EEH9])

HSP 1 Score: 92.4337 bits (228), Expect = 3.796e-19
Identity = 49/150 (32.67%), Postives = 86/150 (57.33%), Query Frame = 2
Query: 1349 SSNVKLSKDGYYISPSIETIDKLVKDKECWVEN-LVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQELPAI-GEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            ++ VKL+K  Y+  P+I  +  ++K+    +E+ L +GR ++G V + G   +  +  D IV F   E  VYPN+E  A  G+ LN+ A++ L  V+  DK T++ +RD  +L ++ + E L + + ++GA F  +  E G W F V++F
Sbjct:  770 AAGVKLTKPDYFSLPTINEMKNMIKNGRVVLEDGLTVGRSSYGSVYWPGRVELKDVALDEIVVFRHREVTVYPNEEEKAPEGQELNRPAEVTLERVWYTDKKTKKEVRDVVKLSEIGWREHLERQTIRMGAAFKDFRAETGSWVFRVDHF 919          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Celegans
Match: npp-10 (Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex protein Nup98 Nuclear pore complex protein Nup96 [Source:UniProtKB/Swiss-Prot;Acc:G5EEH9])

HSP 1 Score: 92.0485 bits (227), Expect = 4.250e-19
Identity = 49/150 (32.67%), Postives = 86/150 (57.33%), Query Frame = 2
Query: 1349 SSNVKLSKDGYYISPSIETIDKLVKDKECWVEN-LVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQELPAI-GEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            ++ VKL+K  Y+  P+I  +  ++K+    +E+ L +GR ++G V + G   +  +  D IV F   E  VYPN+E  A  G+ LN+ A++ L  V+  DK T++ +RD  +L ++ + E L + + ++GA F  +  E G W F V++F
Sbjct:  770 AAGVKLTKPDYFSLPTINEMKNMIKNGRVVLEDGLTVGRSSYGSVYWPGRVELKDVALDEIVVFRHREVTVYPNEEEKAPEGQELNRPAEVTLERVWYTDKKTKKEVRDVVKLSEIGWREHLERQTIRMGAAFKDFRAETGSWVFRVDHF 919          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Celegans
Match: npp-10 (Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex protein Nup98 Nuclear pore complex protein Nup96 [Source:UniProtKB/Swiss-Prot;Acc:G5EEH9])

HSP 1 Score: 92.0485 bits (227), Expect = 4.445e-19
Identity = 49/150 (32.67%), Postives = 86/150 (57.33%), Query Frame = 2
Query: 1349 SSNVKLSKDGYYISPSIETIDKLVKDKECWVEN-LVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQELPAI-GEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            ++ VKL+K  Y+  P+I  +  ++K+    +E+ L +GR ++G V + G   +  +  D IV F   E  VYPN+E  A  G+ LN+ A++ L  V+  DK T++ +RD  +L ++ + E L + + ++GA F  +  E G W F V++F
Sbjct:  772 AAGVKLTKPDYFSLPTINEMKNMIKNGRVVLEDGLTVGRSSYGSVYWPGRVELKDVALDEIVVFRHREVTVYPNEEEKAPEGQELNRPAEVTLERVWYTDKKTKKEVRDVVKLSEIGWREHLERQTIRMGAAFKDFRAETGSWVFRVDHF 921          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Fly
Match: Nup98-96 (gene:FBgn0039120 transcript:FBtr0304567)

HSP 1 Score: 115.161 bits (287), Expect = 2.723e-26
Identity = 58/149 (38.93%), Postives = 87/149 (58.39%), Query Frame = 2
Query: 1352 SNVKLSKDGYYISPSIETIDK-LVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQE-LPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + L + GYY  PS++ +   L +D  C V N  +GR+ +G V F    +V G++ D IV F   E ++YP+ E  P IG+GLN+ AQ+ L  V+P DK+  E I+D +RL++M +  KL +   K    FI Y PE G W F V++F
Sbjct:  880 TGIVLRRVGYYTIPSLDDLRSYLAEDGSCVVPNFTVGREGYGNVFFGKEMDVAGLNLDEIVHFRNKEIIIYPDDENKPPIGQGLNRDAQVTLDQVWPLDKTKHEAIKDPQRLLEMDWEGKLRRVCDKNDTRFIEYRPETGSWVFRVKHF 1028          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Fly
Match: Nup98-96 (gene:FBgn0039120 transcript:FBtr0084460)

HSP 1 Score: 114.775 bits (286), Expect = 4.424e-26
Identity = 58/149 (38.93%), Postives = 87/149 (58.39%), Query Frame = 2
Query: 1352 SNVKLSKDGYYISPSIETIDK-LVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQE-LPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + L + GYY  PS++ +   L +D  C V N  +GR+ +G V F    +V G++ D IV F   E ++YP+ E  P IG+GLN+ AQ+ L  V+P DK+  E I+D +RL++M +  KL +   K    FI Y PE G W F V++F
Sbjct:  880 TGIVLRRVGYYTIPSLDDLRSYLAEDGSCVVPNFTVGREGYGNVFFGKEMDVAGLNLDEIVHFRNKEIIIYPDDENKPPIGQGLNRDAQVTLDQVWPLDKTKHEAIKDPQRLLEMDWEGKLRRVCDKNDTRFIEYRPETGSWVFRVKHF 1028          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Fly
Match: Nup98-96 (gene:FBgn0039120 transcript:FBtr0334894)

HSP 1 Score: 114.775 bits (286), Expect = 4.424e-26
Identity = 58/149 (38.93%), Postives = 87/149 (58.39%), Query Frame = 2
Query: 1352 SNVKLSKDGYYISPSIETIDK-LVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQE-LPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + L + GYY  PS++ +   L +D  C V N  +GR+ +G V F    +V G++ D IV F   E ++YP+ E  P IG+GLN+ AQ+ L  V+P DK+  E I+D +RL++M +  KL +   K    FI Y PE G W F V++F
Sbjct:  880 TGIVLRRVGYYTIPSLDDLRSYLAEDGSCVVPNFTVGREGYGNVFFGKEMDVAGLNLDEIVHFRNKEIIIYPDDENKPPIGQGLNRDAQVTLDQVWPLDKTKHEAIKDPQRLLEMDWEGKLRRVCDKNDTRFIEYRPETGSWVFRVKHF 1028          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Zebrafish
Match: nup98 (nucleoporin 98 [Source:ZFIN;Acc:ZDB-GENE-040426-1180])

HSP 1 Score: 129.028 bits (323), Expect = 1.760e-30
Identity = 64/149 (42.95%), Postives = 91/149 (61.07%), Query Frame = 2
Query: 1352 SNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + LS+ GYY  PS+E + K++ +  EC VEN  IGRK +G V F G  N+  M  D IV F   E +VYP+ ++ P +GEGLN+ A++ L  V+P DK+T   I+  +RL +M +  +L   S K GA F+ Y PE G W FEV +F
Sbjct:  722 AGIVLSRVGYYTIPSMEELGKMLNENGECIVENFTIGRKGYGSVFFPGEVNLTNMILDEIVHFRRKEIIVYPDDKDKPPVGEGLNRRAEVTLDGVWPNDKTTCCQIKSPDRLTEMNYEGRLEAASRKQGARFLEYRPETGSWVFEVAHF 870          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Zebrafish
Match: nup98 (nucleoporin 98 [Source:ZFIN;Acc:ZDB-GENE-040426-1180])

HSP 1 Score: 129.028 bits (323), Expect = 1.761e-30
Identity = 64/149 (42.95%), Postives = 91/149 (61.07%), Query Frame = 2
Query: 1352 SNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + LS+ GYY  PS+E + K++ +  EC VEN  IGRK +G V F G  N+  M  D IV F   E +VYP+ ++ P +GEGLN+ A++ L  V+P DK+T   I+  +RL +M +  +L   S K GA F+ Y PE G W FEV +F
Sbjct:  726 AGIVLSRVGYYTIPSMEELGKMLNENGECIVENFTIGRKGYGSVFFPGEVNLTNMILDEIVHFRRKEIIVYPDDKDKPPVGEGLNRRAEVTLDGVWPNDKTTCCQIKSPDRLTEMNYEGRLEAASRKQGARFLEYRPETGSWVFEVAHF 874          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Zebrafish
Match: nup98 (nucleoporin 98 [Source:ZFIN;Acc:ZDB-GENE-040426-1180])

HSP 1 Score: 129.028 bits (323), Expect = 1.763e-30
Identity = 64/149 (42.95%), Postives = 91/149 (61.07%), Query Frame = 2
Query: 1352 SNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + LS+ GYY  PS+E + K++ +  EC VEN  IGRK +G V F G  N+  M  D IV F   E +VYP+ ++ P +GEGLN+ A++ L  V+P DK+T   I+  +RL +M +  +L   S K GA F+ Y PE G W FEV +F
Sbjct:  733 AGIVLSRVGYYTIPSMEELGKMLNENGECIVENFTIGRKGYGSVFFPGEVNLTNMILDEIVHFRRKEIIVYPDDKDKPPVGEGLNRRAEVTLDGVWPNDKTTCCQIKSPDRLTEMNYEGRLEAASRKQGARFLEYRPETGSWVFEVAHF 881          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Xenopus
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:100145055])

HSP 1 Score: 122.094 bits (305), Expect = 3.966e-28
Identity = 66/172 (38.37%), Postives = 98/172 (56.98%), Query Frame = 2
Query: 1295 SANDDFSDDQSVEYDSIISS----NVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S +  F++D   E + + +S     + L++D YY  PS+E + + V +  EC V    IGR+ FG + F G+ N+  +D DSIV     E +VY  +Q  P +GEGLN+ AQ+ L  V+P DK++   I   ERL +M +  KL   S K GA F+ Y PE+G W F+V +F
Sbjct:  523 SEDASFNEDSFRETEILDASPHPAGIILTRDSYYTIPSMEELARSVDENGECIVNGFTIGREGFGSIYFEGIVNLTNLDLDSIVHIRRKEVIVYVDDQNKPPLGEGLNRPAQVTLDEVWPIDKTSRCMITSPERLSEMNYKSKLENASRKQGAQFVDYRPESGSWVFKVNHF 694          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Xenopus
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:100145055])

HSP 1 Score: 122.094 bits (305), Expect = 3.994e-28
Identity = 66/172 (38.37%), Postives = 98/172 (56.98%), Query Frame = 2
Query: 1295 SANDDFSDDQSVEYDSIISS----NVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S +  F++D   E + + +S     + L++D YY  PS+E + + V +  EC V    IGR+ FG + F G+ N+  +D DSIV     E +VY  +Q  P +GEGLN+ AQ+ L  V+P DK++   I   ERL +M +  KL   S K GA F+ Y PE+G W F+V +F
Sbjct:  676 SEDASFNEDSFRETEILDASPHPAGIILTRDSYYTIPSMEELARSVDENGECIVNGFTIGREGFGSIYFEGIVNLTNLDLDSIVHIRRKEVIVYVDDQNKPPLGEGLNRPAQVTLDEVWPIDKTSRCMITSPERLSEMNYKSKLENASRKQGAQFVDYRPESGSWVFKVNHF 847          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Xenopus
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:100145055])

HSP 1 Score: 122.094 bits (305), Expect = 4.000e-28
Identity = 66/172 (38.37%), Postives = 98/172 (56.98%), Query Frame = 2
Query: 1295 SANDDFSDDQSVEYDSIISS----NVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S +  F++D   E + + +S     + L++D YY  PS+E + + V +  EC V    IGR+ FG + F G+ N+  +D DSIV     E +VY  +Q  P +GEGLN+ AQ+ L  V+P DK++   I   ERL +M +  KL   S K GA F+ Y PE+G W F+V +F
Sbjct:  651 SEDASFNEDSFRETEILDASPHPAGIILTRDSYYTIPSMEELARSVDENGECIVNGFTIGREGFGSIYFEGIVNLTNLDLDSIVHIRRKEVIVYVDDQNKPPLGEGLNRPAQVTLDEVWPIDKTSRCMITSPERLSEMNYKSKLENASRKQGAQFVDYRPESGSWVFKVNHF 822          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Xenopus
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:100145055])

HSP 1 Score: 122.094 bits (305), Expect = 4.055e-28
Identity = 66/172 (38.37%), Postives = 98/172 (56.98%), Query Frame = 2
Query: 1295 SANDDFSDDQSVEYDSIISS----NVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S +  F++D   E + + +S     + L++D YY  PS+E + + V +  EC V    IGR+ FG + F G+ N+  +D DSIV     E +VY  +Q  P +GEGLN+ AQ+ L  V+P DK++   I   ERL +M +  KL   S K GA F+ Y PE+G W F+V +F
Sbjct:  663 SEDASFNEDSFRETEILDASPHPAGIILTRDSYYTIPSMEELARSVDENGECIVNGFTIGREGFGSIYFEGIVNLTNLDLDSIVHIRRKEVIVYVDDQNKPPLGEGLNRPAQVTLDEVWPIDKTSRCMITSPERLSEMNYKSKLENASRKQGAQFVDYRPESGSWVFKVNHF 834          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Xenopus
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:100145055])

HSP 1 Score: 122.094 bits (305), Expect = 4.217e-28
Identity = 66/172 (38.37%), Postives = 98/172 (56.98%), Query Frame = 2
Query: 1295 SANDDFSDDQSVEYDSIISS----NVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S +  F++D   E + + +S     + L++D YY  PS+E + + V +  EC V    IGR+ FG + F G+ N+  +D DSIV     E +VY  +Q  P +GEGLN+ AQ+ L  V+P DK++   I   ERL +M +  KL   S K GA F+ Y PE+G W F+V +F
Sbjct:  695 SEDASFNEDSFRETEILDASPHPAGIILTRDSYYTIPSMEELARSVDENGECIVNGFTIGREGFGSIYFEGIVNLTNLDLDSIVHIRRKEVIVYVDDQNKPPLGEGLNRPAQVTLDEVWPIDKTSRCMITSPERLSEMNYKSKLENASRKQGAQFVDYRPESGSWVFKVNHF 866          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Mouse
Match: Nup98 (nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404])

HSP 1 Score: 110.153 bits (274), Expect = 1.337e-24
Identity = 56/152 (36.84%), Postives = 87/152 (57.24%), Query Frame = 2
Query: 1343 IISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            I  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E +VY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  712 IHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 863          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Mouse
Match: Nup98 (nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404])

HSP 1 Score: 110.153 bits (274), Expect = 1.616e-24
Identity = 56/152 (36.84%), Postives = 87/152 (57.24%), Query Frame = 2
Query: 1343 IISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            I  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E +VY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  729 IHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 880          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Mouse
Match: Nup98 (nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404])

HSP 1 Score: 110.538 bits (275), Expect = 1.683e-24
Identity = 60/168 (35.71%), Postives = 94/168 (55.95%), Query Frame = 2
Query: 1295 SANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S  DD  + ++  Y  I  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E +VY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  714 SLQDDREEIENNAY-HIHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 880          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Mouse
Match: Nup98 (nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404])

HSP 1 Score: 108.612 bits (270), Expect = 4.742e-24
Identity = 60/168 (35.71%), Postives = 94/168 (55.95%), Query Frame = 2
Query: 1295 SANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S  DD  + ++  Y  I  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E +VY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  697 SLQDDREEIENNAY-HIHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 863          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Mouse
Match: Nup98 (nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404])

HSP 1 Score: 108.612 bits (270), Expect = 5.218e-24
Identity = 60/168 (35.71%), Postives = 94/168 (55.95%), Query Frame = 2
Query: 1295 SANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S  DD  + ++  Y  I  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E +VY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  714 SLQDDREEIENNAY-HIHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 880          
BLAST of Peptidase S59 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9VCH5|NUP98_DROME (Nuclear pore complex protein Nup98-Nup96 OS=Drosophila melanogaster OX=7227 GN=Nup98-96 PE=1 SV=3)

HSP 1 Score: 114.775 bits (286), Expect = 4.435e-25
Identity = 58/149 (38.93%), Postives = 87/149 (58.39%), Query Frame = 2
Query: 1352 SNVKLSKDGYYISPSIETIDK-LVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQE-LPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + L + GYY  PS++ +   L +D  C V N  +GR+ +G V F    +V G++ D IV F   E ++YP+ E  P IG+GLN+ AQ+ L  V+P DK+  E I+D +RL++M +  KL +   K    FI Y PE G W F V++F
Sbjct:  880 TGIVLRRVGYYTIPSLDDLRSYLAEDGSCVVPNFTVGREGYGNVFFGKEMDVAGLNLDEIVHFRNKEIIIYPDDENKPPIGQGLNRDAQVTLDQVWPLDKTKHEAIKDPQRLLEMDWEGKLRRVCDKNDTRFIEYRPETGSWVFRVKHF 1028          
BLAST of Peptidase S59 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6PFD9|NUP98_MOUSE (Nuclear pore complex protein Nup98-Nup96 OS=Mus musculus OX=10090 GN=Nup98 PE=1 SV=2)

HSP 1 Score: 110.538 bits (275), Expect = 1.023e-23
Identity = 60/168 (35.71%), Postives = 94/168 (55.95%), Query Frame = 2
Query: 1295 SANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S  DD  + ++  Y  I  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E +VY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  714 SLQDDREEIENNAY-HIHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 880          
BLAST of Peptidase S59 domain-containing protein vs. UniProt/SwissProt
Match: sp|P52948|NUP98_HUMAN (Nuclear pore complex protein Nup98-Nup96 OS=Homo sapiens OX=9606 GN=NUP98 PE=1 SV=4)

HSP 1 Score: 110.153 bits (274), Expect = 1.441e-23
Identity = 59/163 (36.20%), Postives = 93/163 (57.06%), Query Frame = 2
Query: 1316 DDQSVEYDS--IISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            D + +E +S  +  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E VVY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  718 DREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 880          
BLAST of Peptidase S59 domain-containing protein vs. UniProt/SwissProt
Match: sp|P49793|NUP98_RAT (Nuclear pore complex protein Nup98-Nup96 OS=Rattus norvegicus OX=10116 GN=Nup98 PE=1 SV=2)

HSP 1 Score: 109.768 bits (273), Expect = 1.994e-23
Identity = 59/168 (35.12%), Postives = 94/168 (55.95%), Query Frame = 2
Query: 1295 SANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S  DD  + ++  +  I  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E +VY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  714 SLQDDRDEIENSAF-QIHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 880          
BLAST of Peptidase S59 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8RY25|NU98A_ARATH (Nuclear pore complex protein NUP98A OS=Arabidopsis thaliana OX=3702 GN=NUP98A PE=1 SV=1)

HSP 1 Score: 96.6709 bits (239), Expect = 1.808e-19
Identity = 54/148 (36.49%), Postives = 86/148 (58.11%), Query Frame = 2
Query: 1361 KLSKDGYYISPSIETIDKLVKDKECW---VENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQ-ELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            KL +  Y+  P I+ +    +    +   V + V+GR  +G +KF+G T+V  +D +S+V+FN  E +VY ++ + PA+G+GLNK A++ L N+   DK T +   + ER+ K K    L K +   GA F+S+ P  GEW F VE+F
Sbjct:  882 KLRQSDYFTEPRIQELAAKERADPGYCRRVRDFVVGRHGYGSIKFMGETDVRRLDLESLVQFNTREVIVYMDESKKPAVGQGLNKPAEVTLLNIKCIDKKTGKQFTEGERVEKYKMM--LKKKAEAQGAEFVSFDPVKGEWKFRVEHF 1027          
BLAST of Peptidase S59 domain-containing protein vs. TrEMBL
Match: A0A183JI73 (Peptidase S59 domain-containing protein OS=Schistosoma curassoni OX=6186 PE=4 SV=1)

HSP 1 Score: 149.058 bits (375), Expect = 7.359e-35
Identity = 68/149 (45.64%), Postives = 101/149 (67.79%), Query Frame = 2
Query: 1349 SSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            +S V L+K GYY  P+++ + ++V D++C VE+ VIGR+ +G + F G T+VYG++ D+IV     E VVYP+ E  P +G  LNK A++ L +++P DKST EPI+  ERL  M F E+L K + ++ A FI Y PE+G W FEV++F
Sbjct:  107 ASGVILTKPGYYTLPTLDELSEMVIDEKCLVEDFVIGRRLYGHILFPGFTDVYGLNLDNIVHIRRREVVVYPDDEKKPPVGTSLNKRAEVCLESIWPTDKSTREPIKSPERLALMHFEERLEKATRRMDARFIEYRPESGSWVFEVKHF 255          
BLAST of Peptidase S59 domain-containing protein vs. TrEMBL
Match: A0A3P8BCY2 (Peptidase S59 domain-containing protein OS=Schistosoma curassoni OX=6186 GN=SCUD_LOCUS2397 PE=4 SV=1)

HSP 1 Score: 149.058 bits (375), Expect = 7.799e-35
Identity = 68/149 (45.64%), Postives = 101/149 (67.79%), Query Frame = 2
Query: 1349 SSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            +S V L+K GYY  P+++ + ++V D++C VE+ VIGR+ +G + F G T+VYG++ D+IV     E VVYP+ E  P +G  LNK A++ L +++P DKST EPI+  ERL  M F E+L K + ++ A FI Y PE+G W FEV++F
Sbjct:  107 ASGVILTKPGYYTLPTLDELSEMVIDEKCLVEDFVIGRRLYGHILFPGFTDVYGLNLDNIVHIRRREVVVYPDDEKKPPVGTSLNKRAEVCLESIWPTDKSTREPIKSPERLALMHFEERLEKATRRMDARFIEYRPESGSWVFEVKHF 255          
BLAST of Peptidase S59 domain-containing protein vs. TrEMBL
Match: A0A3P8I966 (Peptidase S59 domain-containing protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS9647 PE=4 SV=1)

HSP 1 Score: 149.443 bits (376), Expect = 5.981e-34
Identity = 67/148 (45.27%), Postives = 101/148 (68.24%), Query Frame = 2
Query: 1355 NVKLSKDGYYISPSIETIDKLVKDKE-CWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
             +KL+K GYY  P++E +  +V +K  C VE+ VIGR+++G + F GLT++ G+D D+IV     E VVYP+ E  P +G GLNK A++ L +++P DK+T EPI+  ERL  M+F E+L + + ++ A FI Y PE+G W FEV++F
Sbjct:  578 GIKLTKPGYYTLPTLEELASMVDEKGGCIVEDFVIGRRHYGHILFPGLTDLTGIDLDAIVHIRRREVVVYPDDEKKPTVGLGLNKRAEVCLESIWPTDKATHEPIKSLERLAVMRFEERLERATRRMDARFIEYRPESGSWVFEVKHF 725          
BLAST of Peptidase S59 domain-containing protein vs. TrEMBL
Match: A0A183ARR2 (Peptidase S59 domain-containing protein OS=Echinostoma caproni OX=27848 PE=4 SV=1)

HSP 1 Score: 149.443 bits (376), Expect = 6.259e-34
Identity = 67/148 (45.27%), Postives = 101/148 (68.24%), Query Frame = 2
Query: 1355 NVKLSKDGYYISPSIETIDKLVKDKE-CWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
             +KL+K GYY  P++E +  +V +K  C VE+ VIGR+++G + F GLT++ G+D D+IV     E VVYP+ E  P +G GLNK A++ L +++P DK+T EPI+  ERL  M+F E+L + + ++ A FI Y PE+G W FEV++F
Sbjct:  578 GIKLTKPGYYTLPTLEELASMVDEKGGCIVEDFVIGRRHYGHILFPGLTDLTGIDLDAIVHIRRREVVVYPDDEKKPTVGLGLNKRAEVCLESIWPTDKATHEPIKSLERLAVMRFEERLERATRRMDARFIEYRPESGSWVFEVKHF 725          
BLAST of Peptidase S59 domain-containing protein vs. TrEMBL
Match: A0A430Q4N3 (Nuclear pore complex protein Nup98-Nup96 (Fragment) OS=Schistosoma bovis OX=6184 GN=DC041_0010670 PE=4 SV=1)

HSP 1 Score: 148.673 bits (374), Expect = 1.628e-33
Identity = 68/149 (45.64%), Postives = 101/149 (67.79%), Query Frame = 2
Query: 1349 SSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            +S V L+K GYY  P+++ + ++V D++C VE+ VIGR+ +G + F G T+VYG++ D+IV     E VVYP+ E  P +G  LNK A++ L +++P DKST EPI+  ERL  M F E+L K + ++ A FI Y PE+G W FEV++F
Sbjct:  712 ASGVILTKPGYYTLPTLDELSEMVIDEKCLVEDFVIGRRLYGHILFPGFTDVYGLNLDNIVHIRRREVVVYPDDEKKPPVGTSLNKRAEVCLESIWPTDKSTREPIKSPERLALMHFEERLEKATRRMDARFIEYRPESGSWVFEVKHF 860          

HSP 2 Score: 112.079 bits (279), Expect = 1.178e-21
Identity = 52/117 (44.44%), Postives = 76/117 (64.96%), Query Frame = 2
Query: 1445 NLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            N++   + +G + F G T+VYG++ D+IV     E VVYP+ E  P +G  LNK A++ L +++P DKST EPI+  ERL  M F E+L K + ++ A FI Y PE+G W FEV++F
Sbjct:  912 NIIHRNELYGHILFPGFTDVYGLNLDNIVHIRRREVVVYPDDEKKPPVGTSLNKRAEVCLESIWPTDKSTREPIKSPERLALMHFEERLEKATRRMDARFIEYRPESGSWVFEVKHF 1028          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Cavefish
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:103032416])

HSP 1 Score: 130.183 bits (326), Expect = 7.151e-31
Identity = 64/149 (42.95%), Postives = 91/149 (61.07%), Query Frame = 2
Query: 1352 SNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + LS+ GYY  PS+E + K++ +  EC VEN  +GRK +G V F G  N+  M+ D IV F   E ++YP+ +E P  GEGLN+ A++ L  V+P DK+T   I+  ERL +M +  +L   S K GA F+ Y PE G W FEV +F
Sbjct:  682 AGIVLSRVGYYTIPSMEELGKMLNENGECIVENFTVGRKGYGSVFFPGEVNLTNMNLDEIVHFRRKEVIIYPDDKEKPPEGEGLNRRAEVTLDGVWPNDKTTCTQIKTPERLTEMNYEGRLENASRKQGARFLEYRPETGSWVFEVAHF 830          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Cavefish
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:103032416])

HSP 1 Score: 129.798 bits (325), Expect = 7.387e-31
Identity = 64/149 (42.95%), Postives = 91/149 (61.07%), Query Frame = 2
Query: 1352 SNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + LS+ GYY  PS+E + K++ +  EC VEN  +GRK +G V F G  N+  M+ D IV F   E ++YP+ +E P  GEGLN+ A++ L  V+P DK+T   I+  ERL +M +  +L   S K GA F+ Y PE G W FEV +F
Sbjct:  692 AGIVLSRVGYYTIPSMEELGKMLNENGECIVENFTVGRKGYGSVFFPGEVNLTNMNLDEIVHFRRKEVIIYPDDKEKPPEGEGLNRRAEVTLDGVWPNDKTTCTQIKTPERLTEMNYEGRLENASRKQGARFLEYRPETGSWVFEVAHF 840          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Cavefish
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:103032416])

HSP 1 Score: 129.798 bits (325), Expect = 7.772e-31
Identity = 64/149 (42.95%), Postives = 91/149 (61.07%), Query Frame = 2
Query: 1352 SNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + LS+ GYY  PS+E + K++ +  EC VEN  +GRK +G V F G  N+  M+ D IV F   E ++YP+ +E P  GEGLN+ A++ L  V+P DK+T   I+  ERL +M +  +L   S K GA F+ Y PE G W FEV +F
Sbjct:  724 AGIVLSRVGYYTIPSMEELGKMLNENGECIVENFTVGRKGYGSVFFPGEVNLTNMNLDEIVHFRRKEVIIYPDDKEKPPEGEGLNRRAEVTLDGVWPNDKTTCTQIKTPERLTEMNYEGRLENASRKQGARFLEYRPETGSWVFEVAHF 872          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010326.1 (pep scaffold:Pmarinus_7.0:GL476446:469078:484887:-1 gene:ENSPMAG00000009346.1 transcript:ENSPMAT00000010326.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 134.035 bits (336), Expect = 5.369e-33
Identity = 60/149 (40.27%), Postives = 94/149 (63.09%), Query Frame = 2
Query: 1352 SNVKLSKDGYYISPSIETIDKLV-KDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + L++ GY+  PS+E + ++V +D  C V N VIGR  +G + F G  +V G+D D+IV     E +VYP+    P +G+GLN+ A++ L  V+P DK++  PIR  ERL +M++  +L K + + GA F+ Y PE+G W FEV +F
Sbjct:  748 AGMVLTRAGYFTIPSLEELGRMVDEDGVCTVTNFVIGRVGYGSILFPGRMDVSGLDLDAIVHIRRKEVIVYPDDGSKPRVGQGLNRRAEVTLDGVWPTDKTSRTPIRSPERLQRMEYGARLEKAALRQGARFLEYRPESGSWVFEVNHF 896          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002346.1 (pep scaffold:Pmarinus_7.0:GL477945:9692:37886:-1 gene:ENSPMAG00000002110.1 transcript:ENSPMAT00000002346.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 111.694 bits (278), Expect = 1.077e-25
Identity = 54/149 (36.24%), Postives = 87/149 (58.39%), Query Frame = 2
Query: 1352 SNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + L++ GYY  P ++ + +L  +  +C V N  IGR+ +G + F G  N+  ++ D+IV     E +VYP+    P   EGLN+ A++ L  V+P DK+T   I   ERL++M + E+L + S + GA F  Y PE G W F+V++F
Sbjct:  785 AGIVLTRFGYYTIPPMDELARLTDENGDCIVNNFTIGRQGYGSICFSGEINLKLLNLDAIVHIRRKEVIVYPDDNNKPPCDEGLNRRAEVTLDGVWPLDKTTGRHITSPERLMRMAYEERLERASTRQGALFREYRPETGSWVFDVKHF 933          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Yeast
Match: NUP145 (Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98 [Source:SGD;Acc:S000003060])

HSP 1 Score: 85.5001 bits (210), Expect = 1.065e-17
Identity = 53/153 (34.64%), Postives = 83/153 (54.25%), Query Frame = 2
Query: 1361 KLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKF------VGLTNVYGMD-FDSIVEFNENEFV-VYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            K S  GY+ SPS E +++L   +   V N VIGR+ +G + F         T  +  + F  IV F  ++ V VYP++   P IG GLN  A I L NV+P DK T++P++D  +  + +  ++  +   ++  N+ISY P  G W F+V +F
Sbjct:  455 KSSSFGYWCSPSPEQLERLSLKQLAAVSNFVIGRRGYGCITFQHDVDLTAFTKSFREELFGKIVIFRSSKTVEVYPDEATKPMIGHGLNVPAIITLENVYPVDKKTKKPMKDTTKFAEFQVFDRKLRSMREM--NYISYNPFGGTWTFKVNHF 605          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Yeast
Match: NUP116 (FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p); NUP116 has a paralog, NUP100, that arose from the whole genome duplication [Source:SGD;Acc:S000004650])

HSP 1 Score: 78.1814 bits (191), Expect = 1.766e-15
Identity = 49/163 (30.06%), Postives = 85/163 (52.15%), Query Frame = 2
Query: 1316 DDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDS----IVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVEN 1789
            DD+   +  +   +     + YYISPS++T+      +   V +LV+G K++GK++F+   ++ G+   S    I+ F     ++Y N    P  GEG+N  A+I  FN +P DKST +PI+D    +  +  E+L K+     + F SY  ++G + F V +
Sbjct:  949 DDKKAVFADVAEKDASFINENYYISPSLDTLSSYSLLQLRKVPHLVVGHKSYGKIEFLEPVDLAGIPLTSLGGVIITFEPKTCIIYANLPNRPKRGEGINVRARITCFNCYPVDKSTRKPIKDPNHQLVKRHIERLKKNP---NSKFESYDADSGTYVFIVNH 1108          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Yeast
Match: NUP100 (FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier and is involved in gene tethering at the nuclear periphery; NUP100 has a paralog, NUP116, that arose from the whole genome duplication [Source:SGD;Acc:S000001551])

HSP 1 Score: 73.9442 bits (180), Expect = 3.611e-14
Identity = 51/163 (31.29%), Postives = 85/163 (52.15%), Query Frame = 2
Query: 1325 SVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSI----VEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGAN----FISYTPENGEWAFEVE 1786
            S +   ++S++V   K+ YYISPSIET+      +   + NLVIG +N+GKV+F+   ++     D++    V F      +Y N  + P  GEG+N   ++ L++ FP DK T +PI++         H  L +  AK+  N    F SY P  G +++ ++
Sbjct:  799 SSKVPGLLSNDVTFFKNNYYISPSIETLGNKSLIELRKINNLVIGHRNYGKVEFLEPVDLLNTPLDTLCGDLVTFGPKSCSIYENCSIKPEKGEGINVRCRVTLYSCFPIDKETRKPIKNIT-------HPLLKRSIAKLKENPVYKFESYDPVTGTYSYTID 954          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Nematostella
Match: EDO41704 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S3D3])

HSP 1 Score: 78.1814 bits (191), Expect = 5.543e-15
Identity = 50/144 (34.72%), Postives = 73/144 (50.69%), Query Frame = 2
Query: 1364 LSKDGYYISPSIETIDKLVK-DKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
             S+  YY  PSIE ++ +V  + E WV++ VIGR+ +G+VKF G TNV  ++ D I +          N  LP     ++ L   +L         T  P    ERL +  + E++   +AK+GA FI Y P  G W F VE+F
Sbjct:    3 FSRPEYYTVPSIEQLNDMVDANGEVWVDDFVIGREGYGEVKFPGKTNVADLNLDEIGK----------NLCLPPCVSHVDPLTASLL---------TSTP----ERLKQQGWLERVEAATAKLGATFIDYQPHTGSWVFMVEHF 123          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Medaka
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:101172463])

HSP 1 Score: 125.946 bits (315), Expect = 1.621e-29
Identity = 60/149 (40.27%), Postives = 89/149 (59.73%), Query Frame = 2
Query: 1352 SNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + L++ GYY  P +E +  +V +  EC VEN  +GRK +G + F G  N+  ++ D +V F   E +VYP+ +  P  GEGLN+ A++ L  V+P DK++   IR  ERL  M +  +L K S K GA F+ Y PE+G W FEV +F
Sbjct:  727 AGIVLNRVGYYTIPPLEDLADMVDENGECIVENFTVGRKGYGSIFFPGEVNLTNLNLDEVVHFRRKEVIVYPDDKNKPPEGEGLNRRAEVTLDGVWPNDKTSCTQIRSPERLADMNYEGRLEKASRKQGARFLEYRPESGSWVFEVNHF 875          
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Medaka
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:101172463])

HSP 1 Score: 124.79 bits (312), Expect = 2.579e-29
Identity = 60/149 (40.27%), Postives = 90/149 (60.40%), Query Frame = 2
Query: 1352 SNVKLSKDGYYISPSIETIDKLV-KDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + L++ GYY  P +E +  +V ++ EC VEN  +GRK +G + F G  N+  ++ D +V F   E +VYP+ +  P  GEGLN+ A++ L  V+P DK++   IR  ERL  M +  +L K S K GA F+ Y PE+G W FEV +F
Sbjct:  688 AGIVLNRVGYYTIPPLEDLADMVDENGECIVENFTVGRKGYGSIFFPGEVNLTNLNLDEVVHFRRKEVIVYPDDKNKPPEGEGLNRRAEVTLDGVWPNDKTSCTQIRSPERLADMNYEGRLEKASRKQGARFLEYRPESGSWVFEVNHF 836          
BLAST of Peptidase S59 domain-containing protein vs. Planmine SMEST
Match: SMESG000022300.1 (SMESG000022300.1)

HSP 1 Score: 517.694 bits (1332), Expect = 1.760e-173
Identity = 264/281 (93.95%), Postives = 267/281 (95.02%), Query Frame = 2
Query: 1001 KWLTEDVYQLI----------IHQENINPNTSEEEYLILSASQFMTEPKLNQCSTPLPGKIVLNKSQVSLNCERKTKKVVCFADSVNKHLETFKTIXXXXXXXXXXXXSANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENFLPSKTNV 1813
            K+L  D +Q +          IHQENINPNTSEEEYLILSASQFMTEPKLNQCSTPLPGKIVLNKSQVSLNCERKTKKVVCFADSVNKHLETFKTIEPYECEDEEDYESANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENFLPSKTNV
Sbjct:  667 KYLPADAFQKMVNRRRISTNNIHQENINPNTSEEEYLILSASQFMTEPKLNQCSTPLPGKIVLNKSQVSLNCERKTKKVVCFADSVNKHLETFKTIEPYECEDEEDYESANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENFLPSKTNV 947          

HSP 2 Score: 511.916 bits (1317), Expect = 3.128e-171
Identity = 350/372 (94.09%), Postives = 356/372 (95.70%), Query Frame = 1
Query:    1 PTNAFGGLGTNVHSQPNSIFGPNSQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPFSPSSTGKVAPVLLGNQTNTQSPVFGNSVNNFASNLNQPNTLXXXXXXXXXXXXXXXXXXXXXXYLGMNNQTNNSLITNQFGVNNFNSSIGSPFNISGNMQPNSVHERALEQQFLQNKVLQLVQNNPYGTNHLFMNKFSAIPSVLERAENPLPNQLVSEISPFQRRPIVKNSCKIRSNHIEKLFSGFDEENQSEETFFVKRTNWKYLSPDSFQRSRDNLDESRNKSFNEMNSSSGVSKKVENLKYLPADAFQKMVNRRRISTNN------SPGKYKS*YIRGRISYFISKP 1098
            PTNAFGGLGTNVHSQPNSIFGPNSQNTVIGQGNGGFGNNSQTGFGTNTQQNNLIGSNSINSSTGFFGNTNQTTGLGGSNLPFSPSSTGKVAPVLLGNQTNTQSPVFGNSVNNFASNLNQPNTLGTNSSMFGGGFNSNISGNSFQNYLGMNNQTNNSLITNQFGVNNFNSSIGSPFNISGNMQPNSVHERALEQQFLQNKVLQLVQNNPYGTNHLFMNKFSAIPSVLERAENPLPNQLVSEISPFQRRPIVKNSCKIRSNHIEKLFSGFDEENQSEETFFVKRTNWKYLSPDSFQRSRDNLDESRNKSFNEMNSSSGVSKKVENLKYLPADAFQKMVNRRRISTNN      +P   +  Y+    S F+++P
Sbjct:  343 PTNAFGGLGTNVHSQPNSIFGPNSQNTVIGQGNGGFGNNSQTGFGTNTQQNNLIGSNSINSSTGFFGNTNQTTGLGGSNLPFSPSSTGKVAPVLLGNQTNTQSPVFGNSVNNFASNLNQPNTLGTNSSMFGGGFNSNISGNSFQNYLGMNNQTNNSLITNQFGVNNFNSSIGSPFNISGNMQPNSVHERALEQQFLQNKVLQLVQNNPYGTNHLFMNKFSAIPSVLERAENPLPNQLVSEISPFQRRPIVKNSCKIRSNHIEKLFSGFDEENQSEETFFVKRTNWKYLSPDSFQRSRDNLDESRNKSFNEMNSSSGVSKKVENLKYLPADAFQKMVNRRRISTNNIHQENINPNTSEEEYLILSASQFMTEP 714          
BLAST of Peptidase S59 domain-containing protein vs. Planmine SMEST
Match: SMESG000022283.1 (SMESG000022283.1)

HSP 1 Score: 149.828 bits (377), Expect = 1.662e-37
Identity = 73/157 (46.50%), Postives = 103/157 (65.61%), Query Frame = 2
Query: 1325 SVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S+  D   + ++ L+K+GYY SP+I+ +++LVK  EC+V++  I R  +G +KF G TNVYG++ D  V     E  VYPN ++ P  G+GLNK AQ+ L  +FP DKST E I++  RL  M F E++ K + K+GA FISY P NG W FEVE+F
Sbjct:  670 SINGDVADNCHIILTKEGYYTSPAIDKLNQLVKGTECYVQDFEIHRTGYGSIKFPGNTNVYGLNLDETVNILHKEVSVYPNDDIKPEEGDGLNKQAQVTLMGIFPTDKSTGEIIKEPIRLKTMNFEERIKKVTNKIGARFISYKPINGVWVFEVEHF 826          

HSP 2 Score: 65.0846 bits (157), Expect = 1.400e-10
Identity = 42/118 (35.59%), Postives = 62/118 (52.54%), Query Frame = 1
Query:  595 KVLQLVQNNPYGTNHLFMNKFSAIPSVLERAENPL----PNQLVSEISPFQ------RRPIVKNSCKIRSNHIEKLFSGFDEENQSE------ETFFVKRTNWKYLSPDSFQRSRDNL 900
            KVL LV N PYG N LFM ++  + S L+   + +     N L   I   +      RR I+    KI    +  +FSGFDE+ +        ++F VKR +WKYL P++F++SR +L
Sbjct:  420 KVLSLVSNRPYGINKLFMGQY--MMSTLDTKTSGIDANNTNVLSVAIKRNEAEHVSNRRRILNQKTKINPCQVNNVFSGFDEDEELSIKSHKFDSFMVKREDWKYLPPNAFEKSRKSL 535          
BLAST of Peptidase S59 domain-containing protein vs. Planmine SMEST
Match: SMESG000022283.1 (SMESG000022283.1)

HSP 1 Score: 149.828 bits (377), Expect = 1.691e-37
Identity = 73/157 (46.50%), Postives = 103/157 (65.61%), Query Frame = 2
Query: 1325 SVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S+  D   + ++ L+K+GYY SP+I+ +++LVK  EC+V++  I R  +G +KF G TNVYG++ D  V     E  VYPN ++ P  G+GLNK AQ+ L  +FP DKST E I++  RL  M F E++ K + K+GA FISY P NG W FEVE+F
Sbjct:  670 SINGDVADNCHIILTKEGYYTSPAIDKLNQLVKGTECYVQDFEIHRTGYGSIKFPGNTNVYGLNLDETVNILHKEVSVYPNDDIKPEEGDGLNKQAQVTLMGIFPTDKSTGEIIKEPIRLKTMNFEERIKKVTNKIGARFISYKPINGVWVFEVEHF 826          

HSP 2 Score: 65.0846 bits (157), Expect = 1.436e-10
Identity = 42/118 (35.59%), Postives = 62/118 (52.54%), Query Frame = 1
Query:  595 KVLQLVQNNPYGTNHLFMNKFSAIPSVLERAENPL----PNQLVSEISPFQ------RRPIVKNSCKIRSNHIEKLFSGFDEENQSE------ETFFVKRTNWKYLSPDSFQRSRDNL 900
            KVL LV N PYG N LFM ++  + S L+   + +     N L   I   +      RR I+    KI    +  +FSGFDE+ +        ++F VKR +WKYL P++F++SR +L
Sbjct:  420 KVLSLVSNRPYGINKLFMGQY--MMSTLDTKTSGIDANNTNVLSVAIKRNEAEHVSNRRRILNQKTKINPCQVNNVFSGFDEDEELSIKSHKFDSFMVKREDWKYLPPNAFEKSRKSL 535          
The following BLAST results are available for this feature:
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NUP981.835e-2436.20nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068][more]
NUP981.923e-2436.20nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068][more]
NUP982.646e-2436.20nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068][more]
NUP983.001e-2436.20nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068][more]
NUP983.283e-2436.20nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068][more]
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BLAST of Peptidase S59 domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
npp-103.796e-1932.67Nuclear pore complex protein Nup98-Nup96 Nuclear p... [more]
npp-104.250e-1932.67Nuclear pore complex protein Nup98-Nup96 Nuclear p... [more]
npp-104.445e-1932.67Nuclear pore complex protein Nup98-Nup96 Nuclear p... [more]
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BLAST of Peptidase S59 domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Nup98-962.723e-2638.93gene:FBgn0039120 transcript:FBtr0304567[more]
Nup98-964.424e-2638.93gene:FBgn0039120 transcript:FBtr0084460[more]
Nup98-964.424e-2638.93gene:FBgn0039120 transcript:FBtr0334894[more]
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BLAST of Peptidase S59 domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
nup981.760e-3042.95nucleoporin 98 [Source:ZFIN;Acc:ZDB-GENE-040426-11... [more]
nup981.761e-3042.95nucleoporin 98 [Source:ZFIN;Acc:ZDB-GENE-040426-11... [more]
nup981.763e-3042.95nucleoporin 98 [Source:ZFIN;Acc:ZDB-GENE-040426-11... [more]
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BLAST of Peptidase S59 domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nup983.966e-2838.37nucleoporin 98 [Source:NCBI gene;Acc:100145055][more]
nup983.994e-2838.37nucleoporin 98 [Source:NCBI gene;Acc:100145055][more]
nup984.000e-2838.37nucleoporin 98 [Source:NCBI gene;Acc:100145055][more]
nup984.055e-2838.37nucleoporin 98 [Source:NCBI gene;Acc:100145055][more]
nup984.217e-2838.37nucleoporin 98 [Source:NCBI gene;Acc:100145055][more]
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BLAST of Peptidase S59 domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Nup981.337e-2436.84nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404][more]
Nup981.616e-2436.84nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404][more]
Nup981.683e-2435.71nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404][more]
Nup984.742e-2435.71nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404][more]
Nup985.218e-2435.71nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404][more]
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BLAST of Peptidase S59 domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9VCH5|NUP98_DROME4.435e-2538.93Nuclear pore complex protein Nup98-Nup96 OS=Drosop... [more]
sp|Q6PFD9|NUP98_MOUSE1.023e-2335.71Nuclear pore complex protein Nup98-Nup96 OS=Mus mu... [more]
sp|P52948|NUP98_HUMAN1.441e-2336.20Nuclear pore complex protein Nup98-Nup96 OS=Homo s... [more]
sp|P49793|NUP98_RAT1.994e-2335.12Nuclear pore complex protein Nup98-Nup96 OS=Rattus... [more]
sp|Q8RY25|NU98A_ARATH1.808e-1936.49Nuclear pore complex protein NUP98A OS=Arabidopsis... [more]
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BLAST of Peptidase S59 domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A183JI737.359e-3545.64Peptidase S59 domain-containing protein OS=Schisto... [more]
A0A3P8BCY27.799e-3545.64Peptidase S59 domain-containing protein OS=Schisto... [more]
A0A3P8I9665.981e-3445.27Peptidase S59 domain-containing protein OS=Echinos... [more]
A0A183ARR26.259e-3445.27Peptidase S59 domain-containing protein OS=Echinos... [more]
A0A430Q4N31.628e-3345.64Nuclear pore complex protein Nup98-Nup96 (Fragment... [more]
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BLAST of Peptidase S59 domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
nup987.151e-3142.95nucleoporin 98 [Source:NCBI gene;Acc:103032416][more]
nup987.387e-3142.95nucleoporin 98 [Source:NCBI gene;Acc:103032416][more]
nup987.772e-3142.95nucleoporin 98 [Source:NCBI gene;Acc:103032416][more]
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BLAST of Peptidase S59 domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ENSPMAT00000010326.15.369e-3340.27pep scaffold:Pmarinus_7.0:GL476446:469078:484887:-... [more]
ENSPMAT00000002346.11.077e-2536.24pep scaffold:Pmarinus_7.0:GL477945:9692:37886:-1 g... [more]
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BLAST of Peptidase S59 domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 3
Match NameE-valueIdentityDescription
NUP1451.065e-1734.64Essential protein with distinct roles in two nucle... [more]
NUP1161.766e-1530.06FG-nucleoporin component of central core of the nu... [more]
NUP1003.611e-1431.29FG-nucleoporin component of central core of the nu... [more]
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BLAST of Peptidase S59 domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO417045.543e-1534.72Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Peptidase S59 domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
nup981.621e-2940.27nucleoporin 98 [Source:NCBI gene;Acc:101172463][more]
nup982.579e-2940.27nucleoporin 98 [Source:NCBI gene;Acc:101172463][more]
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BLAST of Peptidase S59 domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000022300.11.760e-17393.95SMESG000022300.1[more]
SMESG000022283.11.662e-3746.50SMESG000022283.1[more]
SMESG000022283.11.691e-3746.50SMESG000022283.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30024965 ID=SMED30024965|Name=Peptidase S59 domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1814bp
CCAACTAATGCTTTTGGTGGCCTAGGAACCAATGTTCATTCACAGCCGAA
TTCGATATTTGGTCCTAATAGCCAGAATACTGTAATTGGACAAGGTAATG
GCGGTTTTGGAAATAATTCTCAAACTGGTTTTGGAACAAATACCCAACAG
AATAATTTAATTGGTTCAAATAGTATTAACTCTTCAACTGGTTTCTTCGG
AAATACCAACCAGACAACCGGATTAGGAGGTTCTAATTTGCCATTTAGCC
CTTCAAGCACGGGAAAAGTGGCTCCTGTCTTATTGGGAAATCAGACAAAT
ACTCAATCACCTGTGTTTGGCAATTCCGTAAACAATTTTGCTTCAAATCT
CAATCAACCGAATACACTTGGAACAAATTCATCAATGTTTGGAGGCGGGT
TTAATAGTAATATTTCCGGAAATTCTTTTCAAAATTATTTAGGAATGAAT
AATCAAACAAATAATTCCTTAATTACTAACCAATTTGGTGTTAATAATTT
CAATTCCTCCATCGGATCTCCTTTCAATATCTCAGGAAACATGCAACCTA
ACTCAGTACATGAGAGAGCTTTAGAGCAACAATTTCTACAAAATAAGGTT
CTTCAACTTGTTCAAAATAATCCTTATGGAACCAATCATTTATTTATGAA
CAAATTCTCTGCAATACCAAGTGTATTAGAAAGAGCGGAAAATCCCCTAC
CAAACCAGCTAGTCAGTGAAATAAGTCCTTTTCAAAGACGACCCATTGTC
AAAAATAGTTGTAAAATTCGTTCGAATCATATTGAAAAATTATTCAGTGG
ATTTGATGAAGAAAATCAGTCTGAAGAAACATTTTTCGTCAAACGAACCA
ATTGGAAGTATTTATCTCCAGATTCATTTCAAAGGAGTCGTGATAATTTA
GATGAGTCTAGAAACAAATCTTTTAATGAAATGAATAGCAGTTCTGGAGT
CAGTAAAAAAGTTGAAAATTTAAAATACTTGCCAGCAGATGCTTTTCAAA
AAATGGTTAACAGAAGACGTATATCAACTAATAATTCACCAGGAAAATAT
AAATCCTAATACATCCGAGGAAGAATATCTTATTTTATCAGCAAGCCAAT
TTATGACCGAACCAAAATTGAATCAGTGTTCAACCCCTTTGCCAGGGAAA
ATAGTTCTAAACAAATCACAAGTTTCACTTAATTGCGAAAGAAAGACAAA
AAAGGTAGTTTGTTTTGCAGATTCGGTCAATAAACACCTTGAAACCTTTA
AGACAATTGAACCCTATGAATGCGAAGATGAGGAAGATTATGAATCTGCA
AACGACGATTTTAGTGACGATCAATCCGTTGAATATGATTCAATTATAAG
TTCAAATGTTAAACTGAGTAAAGATGGGTACTACATATCTCCAAGCATTG
AAACAATTGATAAATTAGTTAAAGATAAAGAATGTTGGGTTGAAAATTTA
GTGATAGGACGAAAAAATTTCGGAAAAGTAAAATTTGTTGGTCTAACCAA
TGTCTATGGAATGGATTTCGACAGTATAGTAGAATTTAATGAAAATGAAT
TCGTAGTTTATCCCAATCAAGAACTGCCAGCAATCGGCGAAGGCTTGAAC
AAGTTAGCTCAGATCGTTTTGTTTAATGTGTTTCCAAAGGATAAATCGAC
TGAAGAACCAATTCGGGATTGCGAGCGTTTGGTAAAAATGAAGTTTCATG
AAAAATTAGCAAAACATTCAGCAAAAGTTGGCGCAAATTTTATAAGTTAC
ACACCTGAAAACGGGGAGTGGGCATTTGAAGTTGAAAATTTTTTGCCTTC
AAAAACCAATGTTG
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protein sequence of SMED30024965-orf-1

>SMED30024965-orf-1 ID=SMED30024965-orf-1|Name=SMED30024965-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=275bp
MLFKKWLTEDVYQLIIHQENINPNTSEEEYLILSASQFMTEPKLNQCSTP
LPGKIVLNKSQVSLNCERKTKKVVCFADSVNKHLETFKTIEPYECEDEED
YESANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDKECW
VENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQELPAIG
EGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGAN
FISYTPENGEWAFEVENFLPSKTNV
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protein sequence of SMED30024965-orf-2

>SMED30024965-orf-2 ID=SMED30024965-orf-2|Name=SMED30024965-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=353bp
PTNAFGGLGTNVHSQPNSIFGPNSQNTVIGQGNGGFGNNSQTGFGTNTQQ
NNLIGSNSINSSTGFFGNTNQTTGLGGSNLPFSPSSTGKVAPVLLGNQTN
TQSPVFGNSVNNFASNLNQPNTLGTNSSMFGGGFNSNISGNSFQNYLGMN
NQTNNSLITNQFGVNNFNSSIGSPFNISGNMQPNSVHERALEQQFLQNKV
LQLVQNNPYGTNHLFMNKFSAIPSVLERAENPLPNQLVSEISPFQRRPIV
KNSCKIRSNHIEKLFSGFDEENQSEETFFVKRTNWKYLSPDSFQRSRDNL
DESRNKSFNEMNSSSGVSKKVENLKYLPADAFQKMVNRRRISTNNSPGKY
KS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0006913nucleocytoplasmic transport
GO:0006810transport
Vocabulary: molecular function
TermDefinition
GO:0017056structural constituent of nuclear pore
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000074oocyte
PLANA:0000231vitelline gland
Vocabulary: INTERPRO
TermDefinition
IPR007230Peptidase_S59
Vocabulary: cellular component
TermDefinition
GO:0005643nuclear pore