Peptidase S59 domain-containing protein

Overview


Name	Peptidase S59 domain-containing protein
Smed ID	SMED30024965
Length (bp)	1814

Neoblast Clusters

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30024965

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
oocyte	SMED30024965	h1SMcG0006480	Contig6174	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017
oocyte	SMED30024965	h1SMcG0006480	Contig6174	newmark_ests	PMID:28434803 Rouhana et al., 2017
vitelline gland	SMED30024965	h1SMcG0006480	Contig6174	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017
vitelline gland	SMED30024965	h1SMcG0006480	Contig6174	newmark_ests	PMID:28434803 Rouhana et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Human
Match: NUP98 (nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068])

HSP 1 Score: 110.538 bits (275), Expect = 1.835e-24
Identity = 59/163 (36.20%), Postives = 93/163 (57.06%), Query Frame = 2

Query: 1316 DDQSVEYDS--IISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            D + +E +S  +  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E VVY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  718 DREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 880

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Human
Match: NUP98 (nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068])

HSP 1 Score: 110.153 bits (274), Expect = 1.923e-24
Identity = 59/163 (36.20%), Postives = 93/163 (57.06%), Query Frame = 2

Query: 1316 DDQSVEYDS--IISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            D + +E +S  +  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E VVY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  701 DREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 863

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Human
Match: NUP98 (nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068])

HSP 1 Score: 110.153 bits (274), Expect = 2.646e-24
Identity = 59/163 (36.20%), Postives = 93/163 (57.06%), Query Frame = 2

Query: 1316 DDQSVEYDS--IISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            D + +E +S  +  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E VVY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  701 DREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 863

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Human
Match: NUP98 (nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068])

HSP 1 Score: 110.153 bits (274), Expect = 3.001e-24
Identity = 59/163 (36.20%), Postives = 93/163 (57.06%), Query Frame = 2

Query: 1316 DDQSVEYDS--IISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            D + +E +S  +  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E VVY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  718 DREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 880

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Human
Match: NUP98 (nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068])

HSP 1 Score: 110.153 bits (274), Expect = 3.283e-24
Identity = 59/163 (36.20%), Postives = 93/163 (57.06%), Query Frame = 2

Query: 1316 DDQSVEYDS--IISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            D + +E +S  +  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E VVY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  701 DREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 863

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Celegans
Match: npp-10 (Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex protein Nup98 Nuclear pore complex protein Nup96 [Source:UniProtKB/Swiss-Prot;Acc:G5EEH9])

HSP 1 Score: 92.4337 bits (228), Expect = 3.796e-19
Identity = 49/150 (32.67%), Postives = 86/150 (57.33%), Query Frame = 2

Query: 1349 SSNVKLSKDGYYISPSIETIDKLVKDKECWVEN-LVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQELPAI-GEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            ++ VKL+K  Y+  P+I  +  ++K+    +E+ L +GR ++G V + G   +  +  D IV F   E  VYPN+E  A  G+ LN+ A++ L  V+  DK T++ +RD  +L ++ + E L + + ++GA F  +  E G W F V++F
Sbjct:  770 AAGVKLTKPDYFSLPTINEMKNMIKNGRVVLEDGLTVGRSSYGSVYWPGRVELKDVALDEIVVFRHREVTVYPNEEEKAPEGQELNRPAEVTLERVWYTDKKTKKEVRDVVKLSEIGWREHLERQTIRMGAAFKDFRAETGSWVFRVDHF 919

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Celegans
Match: npp-10 (Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex protein Nup98 Nuclear pore complex protein Nup96 [Source:UniProtKB/Swiss-Prot;Acc:G5EEH9])

HSP 1 Score: 92.0485 bits (227), Expect = 4.250e-19
Identity = 49/150 (32.67%), Postives = 86/150 (57.33%), Query Frame = 2

Query: 1349 SSNVKLSKDGYYISPSIETIDKLVKDKECWVEN-LVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQELPAI-GEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            ++ VKL+K  Y+  P+I  +  ++K+    +E+ L +GR ++G V + G   +  +  D IV F   E  VYPN+E  A  G+ LN+ A++ L  V+  DK T++ +RD  +L ++ + E L + + ++GA F  +  E G W F V++F
Sbjct:  770 AAGVKLTKPDYFSLPTINEMKNMIKNGRVVLEDGLTVGRSSYGSVYWPGRVELKDVALDEIVVFRHREVTVYPNEEEKAPEGQELNRPAEVTLERVWYTDKKTKKEVRDVVKLSEIGWREHLERQTIRMGAAFKDFRAETGSWVFRVDHF 919

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Celegans
Match: npp-10 (Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex protein Nup98 Nuclear pore complex protein Nup96 [Source:UniProtKB/Swiss-Prot;Acc:G5EEH9])

HSP 1 Score: 92.0485 bits (227), Expect = 4.445e-19
Identity = 49/150 (32.67%), Postives = 86/150 (57.33%), Query Frame = 2

Query: 1349 SSNVKLSKDGYYISPSIETIDKLVKDKECWVEN-LVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQELPAI-GEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            ++ VKL+K  Y+  P+I  +  ++K+    +E+ L +GR ++G V + G   +  +  D IV F   E  VYPN+E  A  G+ LN+ A++ L  V+  DK T++ +RD  +L ++ + E L + + ++GA F  +  E G W F V++F
Sbjct:  772 AAGVKLTKPDYFSLPTINEMKNMIKNGRVVLEDGLTVGRSSYGSVYWPGRVELKDVALDEIVVFRHREVTVYPNEEEKAPEGQELNRPAEVTLERVWYTDKKTKKEVRDVVKLSEIGWREHLERQTIRMGAAFKDFRAETGSWVFRVDHF 921

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Fly
Match: Nup98-96 (gene:FBgn0039120 transcript:FBtr0304567)

HSP 1 Score: 115.161 bits (287), Expect = 2.723e-26
Identity = 58/149 (38.93%), Postives = 87/149 (58.39%), Query Frame = 2

Query: 1352 SNVKLSKDGYYISPSIETIDK-LVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQE-LPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + L + GYY  PS++ +   L +D  C V N  +GR+ +G V F    +V G++ D IV F   E ++YP+ E  P IG+GLN+ AQ+ L  V+P DK+  E I+D +RL++M +  KL +   K    FI Y PE G W F V++F
Sbjct:  880 TGIVLRRVGYYTIPSLDDLRSYLAEDGSCVVPNFTVGREGYGNVFFGKEMDVAGLNLDEIVHFRNKEIIIYPDDENKPPIGQGLNRDAQVTLDQVWPLDKTKHEAIKDPQRLLEMDWEGKLRRVCDKNDTRFIEYRPETGSWVFRVKHF 1028

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Fly
Match: Nup98-96 (gene:FBgn0039120 transcript:FBtr0084460)

HSP 1 Score: 114.775 bits (286), Expect = 4.424e-26
Identity = 58/149 (38.93%), Postives = 87/149 (58.39%), Query Frame = 2

Query: 1352 SNVKLSKDGYYISPSIETIDK-LVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQE-LPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + L + GYY  PS++ +   L +D  C V N  +GR+ +G V F    +V G++ D IV F   E ++YP+ E  P IG+GLN+ AQ+ L  V+P DK+  E I+D +RL++M +  KL +   K    FI Y PE G W F V++F
Sbjct:  880 TGIVLRRVGYYTIPSLDDLRSYLAEDGSCVVPNFTVGREGYGNVFFGKEMDVAGLNLDEIVHFRNKEIIIYPDDENKPPIGQGLNRDAQVTLDQVWPLDKTKHEAIKDPQRLLEMDWEGKLRRVCDKNDTRFIEYRPETGSWVFRVKHF 1028

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Fly
Match: Nup98-96 (gene:FBgn0039120 transcript:FBtr0334894)

HSP 1 Score: 114.775 bits (286), Expect = 4.424e-26
Identity = 58/149 (38.93%), Postives = 87/149 (58.39%), Query Frame = 2

Query: 1352 SNVKLSKDGYYISPSIETIDK-LVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQE-LPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + L + GYY  PS++ +   L +D  C V N  +GR+ +G V F    +V G++ D IV F   E ++YP+ E  P IG+GLN+ AQ+ L  V+P DK+  E I+D +RL++M +  KL +   K    FI Y PE G W F V++F
Sbjct:  880 TGIVLRRVGYYTIPSLDDLRSYLAEDGSCVVPNFTVGREGYGNVFFGKEMDVAGLNLDEIVHFRNKEIIIYPDDENKPPIGQGLNRDAQVTLDQVWPLDKTKHEAIKDPQRLLEMDWEGKLRRVCDKNDTRFIEYRPETGSWVFRVKHF 1028

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Zebrafish
Match: nup98 (nucleoporin 98 [Source:ZFIN;Acc:ZDB-GENE-040426-1180])

HSP 1 Score: 129.028 bits (323), Expect = 1.760e-30
Identity = 64/149 (42.95%), Postives = 91/149 (61.07%), Query Frame = 2

Query: 1352 SNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + LS+ GYY  PS+E + K++ +  EC VEN  IGRK +G V F G  N+  M  D IV F   E +VYP+ ++ P +GEGLN+ A++ L  V+P DK+T   I+  +RL +M +  +L   S K GA F+ Y PE G W FEV +F
Sbjct:  722 AGIVLSRVGYYTIPSMEELGKMLNENGECIVENFTIGRKGYGSVFFPGEVNLTNMILDEIVHFRRKEIIVYPDDKDKPPVGEGLNRRAEVTLDGVWPNDKTTCCQIKSPDRLTEMNYEGRLEAASRKQGARFLEYRPETGSWVFEVAHF 870

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Zebrafish
Match: nup98 (nucleoporin 98 [Source:ZFIN;Acc:ZDB-GENE-040426-1180])

HSP 1 Score: 129.028 bits (323), Expect = 1.761e-30
Identity = 64/149 (42.95%), Postives = 91/149 (61.07%), Query Frame = 2

Query: 1352 SNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + LS+ GYY  PS+E + K++ +  EC VEN  IGRK +G V F G  N+  M  D IV F   E +VYP+ ++ P +GEGLN+ A++ L  V+P DK+T   I+  +RL +M +  +L   S K GA F+ Y PE G W FEV +F
Sbjct:  726 AGIVLSRVGYYTIPSMEELGKMLNENGECIVENFTIGRKGYGSVFFPGEVNLTNMILDEIVHFRRKEIIVYPDDKDKPPVGEGLNRRAEVTLDGVWPNDKTTCCQIKSPDRLTEMNYEGRLEAASRKQGARFLEYRPETGSWVFEVAHF 874

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Zebrafish
Match: nup98 (nucleoporin 98 [Source:ZFIN;Acc:ZDB-GENE-040426-1180])

HSP 1 Score: 129.028 bits (323), Expect = 1.763e-30
Identity = 64/149 (42.95%), Postives = 91/149 (61.07%), Query Frame = 2

Query: 1352 SNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + LS+ GYY  PS+E + K++ +  EC VEN  IGRK +G V F G  N+  M  D IV F   E +VYP+ ++ P +GEGLN+ A++ L  V+P DK+T   I+  +RL +M +  +L   S K GA F+ Y PE G W FEV +F
Sbjct:  733 AGIVLSRVGYYTIPSMEELGKMLNENGECIVENFTIGRKGYGSVFFPGEVNLTNMILDEIVHFRRKEIIVYPDDKDKPPVGEGLNRRAEVTLDGVWPNDKTTCCQIKSPDRLTEMNYEGRLEAASRKQGARFLEYRPETGSWVFEVAHF 881

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Xenopus
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:100145055])

HSP 1 Score: 122.094 bits (305), Expect = 3.966e-28
Identity = 66/172 (38.37%), Postives = 98/172 (56.98%), Query Frame = 2

Query: 1295 SANDDFSDDQSVEYDSIISS----NVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S +  F++D   E + + +S     + L++D YY  PS+E + + V +  EC V    IGR+ FG + F G+ N+  +D DSIV     E +VY  +Q  P +GEGLN+ AQ+ L  V+P DK++   I   ERL +M +  KL   S K GA F+ Y PE+G W F+V +F
Sbjct:  523 SEDASFNEDSFRETEILDASPHPAGIILTRDSYYTIPSMEELARSVDENGECIVNGFTIGREGFGSIYFEGIVNLTNLDLDSIVHIRRKEVIVYVDDQNKPPLGEGLNRPAQVTLDEVWPIDKTSRCMITSPERLSEMNYKSKLENASRKQGAQFVDYRPESGSWVFKVNHF 694

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Xenopus
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:100145055])

HSP 1 Score: 122.094 bits (305), Expect = 3.994e-28
Identity = 66/172 (38.37%), Postives = 98/172 (56.98%), Query Frame = 2

Query: 1295 SANDDFSDDQSVEYDSIISS----NVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S +  F++D   E + + +S     + L++D YY  PS+E + + V +  EC V    IGR+ FG + F G+ N+  +D DSIV     E +VY  +Q  P +GEGLN+ AQ+ L  V+P DK++   I   ERL +M +  KL   S K GA F+ Y PE+G W F+V +F
Sbjct:  676 SEDASFNEDSFRETEILDASPHPAGIILTRDSYYTIPSMEELARSVDENGECIVNGFTIGREGFGSIYFEGIVNLTNLDLDSIVHIRRKEVIVYVDDQNKPPLGEGLNRPAQVTLDEVWPIDKTSRCMITSPERLSEMNYKSKLENASRKQGAQFVDYRPESGSWVFKVNHF 847

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Xenopus
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:100145055])

HSP 1 Score: 122.094 bits (305), Expect = 4.000e-28
Identity = 66/172 (38.37%), Postives = 98/172 (56.98%), Query Frame = 2

Query: 1295 SANDDFSDDQSVEYDSIISS----NVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S +  F++D   E + + +S     + L++D YY  PS+E + + V +  EC V    IGR+ FG + F G+ N+  +D DSIV     E +VY  +Q  P +GEGLN+ AQ+ L  V+P DK++   I   ERL +M +  KL   S K GA F+ Y PE+G W F+V +F
Sbjct:  651 SEDASFNEDSFRETEILDASPHPAGIILTRDSYYTIPSMEELARSVDENGECIVNGFTIGREGFGSIYFEGIVNLTNLDLDSIVHIRRKEVIVYVDDQNKPPLGEGLNRPAQVTLDEVWPIDKTSRCMITSPERLSEMNYKSKLENASRKQGAQFVDYRPESGSWVFKVNHF 822

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Xenopus
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:100145055])

HSP 1 Score: 122.094 bits (305), Expect = 4.055e-28
Identity = 66/172 (38.37%), Postives = 98/172 (56.98%), Query Frame = 2

Query: 1295 SANDDFSDDQSVEYDSIISS----NVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S +  F++D   E + + +S     + L++D YY  PS+E + + V +  EC V    IGR+ FG + F G+ N+  +D DSIV     E +VY  +Q  P +GEGLN+ AQ+ L  V+P DK++   I   ERL +M +  KL   S K GA F+ Y PE+G W F+V +F
Sbjct:  663 SEDASFNEDSFRETEILDASPHPAGIILTRDSYYTIPSMEELARSVDENGECIVNGFTIGREGFGSIYFEGIVNLTNLDLDSIVHIRRKEVIVYVDDQNKPPLGEGLNRPAQVTLDEVWPIDKTSRCMITSPERLSEMNYKSKLENASRKQGAQFVDYRPESGSWVFKVNHF 834

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Xenopus
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:100145055])

HSP 1 Score: 122.094 bits (305), Expect = 4.217e-28
Identity = 66/172 (38.37%), Postives = 98/172 (56.98%), Query Frame = 2

Query: 1295 SANDDFSDDQSVEYDSIISS----NVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S +  F++D   E + + +S     + L++D YY  PS+E + + V +  EC V    IGR+ FG + F G+ N+  +D DSIV     E +VY  +Q  P +GEGLN+ AQ+ L  V+P DK++   I   ERL +M +  KL   S K GA F+ Y PE+G W F+V +F
Sbjct:  695 SEDASFNEDSFRETEILDASPHPAGIILTRDSYYTIPSMEELARSVDENGECIVNGFTIGREGFGSIYFEGIVNLTNLDLDSIVHIRRKEVIVYVDDQNKPPLGEGLNRPAQVTLDEVWPIDKTSRCMITSPERLSEMNYKSKLENASRKQGAQFVDYRPESGSWVFKVNHF 866

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BLAST of Peptidase S59 domain-containing protein vs. Ensembl Mouse
Match: Nup98 (nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404])

HSP 1 Score: 110.153 bits (274), Expect = 1.337e-24
Identity = 56/152 (36.84%), Postives = 87/152 (57.24%), Query Frame = 2

Query: 1343 IISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            I  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E +VY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  712 IHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 863

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Mouse
Match: Nup98 (nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404])

HSP 1 Score: 110.153 bits (274), Expect = 1.616e-24
Identity = 56/152 (36.84%), Postives = 87/152 (57.24%), Query Frame = 2

Query: 1343 IISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            I  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E +VY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  729 IHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 880

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Mouse
Match: Nup98 (nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404])

HSP 1 Score: 110.538 bits (275), Expect = 1.683e-24
Identity = 60/168 (35.71%), Postives = 94/168 (55.95%), Query Frame = 2

Query: 1295 SANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S  DD  + ++  Y  I  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E +VY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  714 SLQDDREEIENNAY-HIHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 880

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Mouse
Match: Nup98 (nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404])

HSP 1 Score: 108.612 bits (270), Expect = 4.742e-24
Identity = 60/168 (35.71%), Postives = 94/168 (55.95%), Query Frame = 2

Query: 1295 SANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S  DD  + ++  Y  I  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E +VY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  697 SLQDDREEIENNAY-HIHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 863

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Mouse
Match: Nup98 (nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404])

HSP 1 Score: 108.612 bits (270), Expect = 5.218e-24
Identity = 60/168 (35.71%), Postives = 94/168 (55.95%), Query Frame = 2

Query: 1295 SANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S  DD  + ++  Y  I  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E +VY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  714 SLQDDREEIENNAY-HIHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 880

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BLAST of Peptidase S59 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9VCH5|NUP98_DROME (Nuclear pore complex protein Nup98-Nup96 OS=Drosophila melanogaster OX=7227 GN=Nup98-96 PE=1 SV=3)

HSP 1 Score: 114.775 bits (286), Expect = 4.435e-25
Identity = 58/149 (38.93%), Postives = 87/149 (58.39%), Query Frame = 2

Query: 1352 SNVKLSKDGYYISPSIETIDK-LVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQE-LPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + L + GYY  PS++ +   L +D  C V N  +GR+ +G V F    +V G++ D IV F   E ++YP+ E  P IG+GLN+ AQ+ L  V+P DK+  E I+D +RL++M +  KL +   K    FI Y PE G W F V++F
Sbjct:  880 TGIVLRRVGYYTIPSLDDLRSYLAEDGSCVVPNFTVGREGYGNVFFGKEMDVAGLNLDEIVHFRNKEIIIYPDDENKPPIGQGLNRDAQVTLDQVWPLDKTKHEAIKDPQRLLEMDWEGKLRRVCDKNDTRFIEYRPETGSWVFRVKHF 1028

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BLAST of Peptidase S59 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6PFD9|NUP98_MOUSE (Nuclear pore complex protein Nup98-Nup96 OS=Mus musculus OX=10090 GN=Nup98 PE=1 SV=2)

HSP 1 Score: 110.538 bits (275), Expect = 1.023e-23
Identity = 60/168 (35.71%), Postives = 94/168 (55.95%), Query Frame = 2

Query: 1295 SANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S  DD  + ++  Y  I  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E +VY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  714 SLQDDREEIENNAY-HIHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 880

[Close]

BLAST of Peptidase S59 domain-containing protein vs. UniProt/SwissProt
Match: sp|P52948|NUP98_HUMAN (Nuclear pore complex protein Nup98-Nup96 OS=Homo sapiens OX=9606 GN=NUP98 PE=1 SV=4)

HSP 1 Score: 110.153 bits (274), Expect = 1.441e-23
Identity = 59/163 (36.20%), Postives = 93/163 (57.06%), Query Frame = 2

Query: 1316 DDQSVEYDS--IISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            D + +E +S  +  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E VVY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  718 DREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 880

[Close]

BLAST of Peptidase S59 domain-containing protein vs. UniProt/SwissProt
Match: sp|P49793|NUP98_RAT (Nuclear pore complex protein Nup98-Nup96 OS=Rattus norvegicus OX=10116 GN=Nup98 PE=1 SV=2)

HSP 1 Score: 109.768 bits (273), Expect = 1.994e-23
Identity = 59/168 (35.12%), Postives = 94/168 (55.95%), Query Frame = 2

Query: 1295 SANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVY-PNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S  DD  + ++  +  I  + + L+K GYY  PS++ + K+  +K EC V +  IGRK +G + F G  N+  ++ D IV     E +VY  + + P +GEGLN+ A++ L  V+P DK++   I+  +RL  + +  +L   S K GA F  Y PE G W F+V +F
Sbjct:  714 SLQDDRDEIENSAF-QIHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHF 880

[Close]

BLAST of Peptidase S59 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8RY25|NU98A_ARATH (Nuclear pore complex protein NUP98A OS=Arabidopsis thaliana OX=3702 GN=NUP98A PE=1 SV=1)

HSP 1 Score: 96.6709 bits (239), Expect = 1.808e-19
Identity = 54/148 (36.49%), Postives = 86/148 (58.11%), Query Frame = 2

Query: 1361 KLSKDGYYISPSIETIDKLVKDKECW---VENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQ-ELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            KL +  Y+  P I+ +    +    +   V + V+GR  +G +KF+G T+V  +D +S+V+FN  E +VY ++ + PA+G+GLNK A++ L N+   DK T +   + ER+ K K    L K +   GA F+S+ P  GEW F VE+F
Sbjct:  882 KLRQSDYFTEPRIQELAAKERADPGYCRRVRDFVVGRHGYGSIKFMGETDVRRLDLESLVQFNTREVIVYMDESKKPAVGQGLNKPAEVTLLNIKCIDKKTGKQFTEGERVEKYKMM--LKKKAEAQGAEFVSFDPVKGEWKFRVEHF 1027

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BLAST of Peptidase S59 domain-containing protein vs. TrEMBL
Match: A0A183JI73 (Peptidase S59 domain-containing protein OS=Schistosoma curassoni OX=6186 PE=4 SV=1)

HSP 1 Score: 149.058 bits (375), Expect = 7.359e-35
Identity = 68/149 (45.64%), Postives = 101/149 (67.79%), Query Frame = 2

Query: 1349 SSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            +S V L+K GYY  P+++ + ++V D++C VE+ VIGR+ +G + F G T+VYG++ D+IV     E VVYP+ E  P +G  LNK A++ L +++P DKST EPI+  ERL  M F E+L K + ++ A FI Y PE+G W FEV++F
Sbjct:  107 ASGVILTKPGYYTLPTLDELSEMVIDEKCLVEDFVIGRRLYGHILFPGFTDVYGLNLDNIVHIRRREVVVYPDDEKKPPVGTSLNKRAEVCLESIWPTDKSTREPIKSPERLALMHFEERLEKATRRMDARFIEYRPESGSWVFEVKHF 255

[Close]

BLAST of Peptidase S59 domain-containing protein vs. TrEMBL
Match: A0A3P8BCY2 (Peptidase S59 domain-containing protein OS=Schistosoma curassoni OX=6186 GN=SCUD_LOCUS2397 PE=4 SV=1)

HSP 1 Score: 149.058 bits (375), Expect = 7.799e-35
Identity = 68/149 (45.64%), Postives = 101/149 (67.79%), Query Frame = 2

Query: 1349 SSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            +S V L+K GYY  P+++ + ++V D++C VE+ VIGR+ +G + F G T+VYG++ D+IV     E VVYP+ E  P +G  LNK A++ L +++P DKST EPI+  ERL  M F E+L K + ++ A FI Y PE+G W FEV++F
Sbjct:  107 ASGVILTKPGYYTLPTLDELSEMVIDEKCLVEDFVIGRRLYGHILFPGFTDVYGLNLDNIVHIRRREVVVYPDDEKKPPVGTSLNKRAEVCLESIWPTDKSTREPIKSPERLALMHFEERLEKATRRMDARFIEYRPESGSWVFEVKHF 255

[Close]

BLAST of Peptidase S59 domain-containing protein vs. TrEMBL
Match: A0A3P8I966 (Peptidase S59 domain-containing protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS9647 PE=4 SV=1)

HSP 1 Score: 149.443 bits (376), Expect = 5.981e-34
Identity = 67/148 (45.27%), Postives = 101/148 (68.24%), Query Frame = 2

Query: 1355 NVKLSKDGYYISPSIETIDKLVKDKE-CWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
             +KL+K GYY  P++E +  +V +K  C VE+ VIGR+++G + F GLT++ G+D D+IV     E VVYP+ E  P +G GLNK A++ L +++P DK+T EPI+  ERL  M+F E+L + + ++ A FI Y PE+G W FEV++F
Sbjct:  578 GIKLTKPGYYTLPTLEELASMVDEKGGCIVEDFVIGRRHYGHILFPGLTDLTGIDLDAIVHIRRREVVVYPDDEKKPTVGLGLNKRAEVCLESIWPTDKATHEPIKSLERLAVMRFEERLERATRRMDARFIEYRPESGSWVFEVKHF 725

[Close]

BLAST of Peptidase S59 domain-containing protein vs. TrEMBL
Match: A0A183ARR2 (Peptidase S59 domain-containing protein OS=Echinostoma caproni OX=27848 PE=4 SV=1)

HSP 1 Score: 149.443 bits (376), Expect = 6.259e-34
Identity = 67/148 (45.27%), Postives = 101/148 (68.24%), Query Frame = 2

Query: 1355 NVKLSKDGYYISPSIETIDKLVKDKE-CWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
             +KL+K GYY  P++E +  +V +K  C VE+ VIGR+++G + F GLT++ G+D D+IV     E VVYP+ E  P +G GLNK A++ L +++P DK+T EPI+  ERL  M+F E+L + + ++ A FI Y PE+G W FEV++F
Sbjct:  578 GIKLTKPGYYTLPTLEELASMVDEKGGCIVEDFVIGRRHYGHILFPGLTDLTGIDLDAIVHIRRREVVVYPDDEKKPTVGLGLNKRAEVCLESIWPTDKATHEPIKSLERLAVMRFEERLERATRRMDARFIEYRPESGSWVFEVKHF 725

[Close]

BLAST of Peptidase S59 domain-containing protein vs. TrEMBL
Match: A0A430Q4N3 (Nuclear pore complex protein Nup98-Nup96 (Fragment) OS=Schistosoma bovis OX=6184 GN=DC041_0010670 PE=4 SV=1)

HSP 1 Score: 148.673 bits (374), Expect = 1.628e-33
Identity = 68/149 (45.64%), Postives = 101/149 (67.79%), Query Frame = 2

Query: 1349 SSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            +S V L+K GYY  P+++ + ++V D++C VE+ VIGR+ +G + F G T+VYG++ D+IV     E VVYP+ E  P +G  LNK A++ L +++P DKST EPI+  ERL  M F E+L K + ++ A FI Y PE+G W FEV++F
Sbjct:  712 ASGVILTKPGYYTLPTLDELSEMVIDEKCLVEDFVIGRRLYGHILFPGFTDVYGLNLDNIVHIRRREVVVYPDDEKKPPVGTSLNKRAEVCLESIWPTDKSTREPIKSPERLALMHFEERLEKATRRMDARFIEYRPESGSWVFEVKHF 860

HSP 2 Score: 112.079 bits (279), Expect = 1.178e-21
Identity = 52/117 (44.44%), Postives = 76/117 (64.96%), Query Frame = 2

Query: 1445 NLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            N++   + +G + F G T+VYG++ D+IV     E VVYP+ E  P +G  LNK A++ L +++P DKST EPI+  ERL  M F E+L K + ++ A FI Y PE+G W FEV++F
Sbjct:  912 NIIHRNELYGHILFPGFTDVYGLNLDNIVHIRRREVVVYPDDEKKPPVGTSLNKRAEVCLESIWPTDKSTREPIKSPERLALMHFEERLEKATRRMDARFIEYRPESGSWVFEVKHF 1028

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Cavefish
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:103032416])

HSP 1 Score: 130.183 bits (326), Expect = 7.151e-31
Identity = 64/149 (42.95%), Postives = 91/149 (61.07%), Query Frame = 2

Query: 1352 SNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + LS+ GYY  PS+E + K++ +  EC VEN  +GRK +G V F G  N+  M+ D IV F   E ++YP+ +E P  GEGLN+ A++ L  V+P DK+T   I+  ERL +M +  +L   S K GA F+ Y PE G W FEV +F
Sbjct:  682 AGIVLSRVGYYTIPSMEELGKMLNENGECIVENFTVGRKGYGSVFFPGEVNLTNMNLDEIVHFRRKEVIIYPDDKEKPPEGEGLNRRAEVTLDGVWPNDKTTCTQIKTPERLTEMNYEGRLENASRKQGARFLEYRPETGSWVFEVAHF 830

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Cavefish
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:103032416])

HSP 1 Score: 129.798 bits (325), Expect = 7.387e-31
Identity = 64/149 (42.95%), Postives = 91/149 (61.07%), Query Frame = 2

Query: 1352 SNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + LS+ GYY  PS+E + K++ +  EC VEN  +GRK +G V F G  N+  M+ D IV F   E ++YP+ +E P  GEGLN+ A++ L  V+P DK+T   I+  ERL +M +  +L   S K GA F+ Y PE G W FEV +F
Sbjct:  692 AGIVLSRVGYYTIPSMEELGKMLNENGECIVENFTVGRKGYGSVFFPGEVNLTNMNLDEIVHFRRKEVIIYPDDKEKPPEGEGLNRRAEVTLDGVWPNDKTTCTQIKTPERLTEMNYEGRLENASRKQGARFLEYRPETGSWVFEVAHF 840

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Cavefish
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:103032416])

HSP 1 Score: 129.798 bits (325), Expect = 7.772e-31
Identity = 64/149 (42.95%), Postives = 91/149 (61.07%), Query Frame = 2

Query: 1352 SNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + LS+ GYY  PS+E + K++ +  EC VEN  +GRK +G V F G  N+  M+ D IV F   E ++YP+ +E P  GEGLN+ A++ L  V+P DK+T   I+  ERL +M +  +L   S K GA F+ Y PE G W FEV +F
Sbjct:  724 AGIVLSRVGYYTIPSMEELGKMLNENGECIVENFTVGRKGYGSVFFPGEVNLTNMNLDEIVHFRRKEVIIYPDDKEKPPEGEGLNRRAEVTLDGVWPNDKTTCTQIKTPERLTEMNYEGRLENASRKQGARFLEYRPETGSWVFEVAHF 872

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010326.1 (pep scaffold:Pmarinus_7.0:GL476446:469078:484887:-1 gene:ENSPMAG00000009346.1 transcript:ENSPMAT00000010326.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 134.035 bits (336), Expect = 5.369e-33
Identity = 60/149 (40.27%), Postives = 94/149 (63.09%), Query Frame = 2

Query: 1352 SNVKLSKDGYYISPSIETIDKLV-KDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + L++ GY+  PS+E + ++V +D  C V N VIGR  +G + F G  +V G+D D+IV     E +VYP+    P +G+GLN+ A++ L  V+P DK++  PIR  ERL +M++  +L K + + GA F+ Y PE+G W FEV +F
Sbjct:  748 AGMVLTRAGYFTIPSLEELGRMVDEDGVCTVTNFVIGRVGYGSILFPGRMDVSGLDLDAIVHIRRKEVIVYPDDGSKPRVGQGLNRRAEVTLDGVWPTDKTSRTPIRSPERLQRMEYGARLEKAALRQGARFLEYRPESGSWVFEVNHF 896

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002346.1 (pep scaffold:Pmarinus_7.0:GL477945:9692:37886:-1 gene:ENSPMAG00000002110.1 transcript:ENSPMAT00000002346.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 111.694 bits (278), Expect = 1.077e-25
Identity = 54/149 (36.24%), Postives = 87/149 (58.39%), Query Frame = 2

Query: 1352 SNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + L++ GYY  P ++ + +L  +  +C V N  IGR+ +G + F G  N+  ++ D+IV     E +VYP+    P   EGLN+ A++ L  V+P DK+T   I   ERL++M + E+L + S + GA F  Y PE G W F+V++F
Sbjct:  785 AGIVLTRFGYYTIPPMDELARLTDENGDCIVNNFTIGRQGYGSICFSGEINLKLLNLDAIVHIRRKEVIVYPDDNNKPPCDEGLNRRAEVTLDGVWPLDKTTGRHITSPERLMRMAYEERLERASTRQGALFREYRPETGSWVFDVKHF 933

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Yeast
Match: NUP145 (Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98 [Source:SGD;Acc:S000003060])

HSP 1 Score: 85.5001 bits (210), Expect = 1.065e-17
Identity = 53/153 (34.64%), Postives = 83/153 (54.25%), Query Frame = 2

Query: 1361 KLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKF------VGLTNVYGMD-FDSIVEFNENEFV-VYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            K S  GY+ SPS E +++L   +   V N VIGR+ +G + F         T  +  + F  IV F  ++ V VYP++   P IG GLN  A I L NV+P DK T++P++D  +  + +  ++  +   ++  N+ISY P  G W F+V +F
Sbjct:  455 KSSSFGYWCSPSPEQLERLSLKQLAAVSNFVIGRRGYGCITFQHDVDLTAFTKSFREELFGKIVIFRSSKTVEVYPDEATKPMIGHGLNVPAIITLENVYPVDKKTKKPMKDTTKFAEFQVFDRKLRSMREM--NYISYNPFGGTWTFKVNHF 605

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Yeast
Match: NUP116 (FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p); NUP116 has a paralog, NUP100, that arose from the whole genome duplication [Source:SGD;Acc:S000004650])

HSP 1 Score: 78.1814 bits (191), Expect = 1.766e-15
Identity = 49/163 (30.06%), Postives = 85/163 (52.15%), Query Frame = 2

Query: 1316 DDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDS----IVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVEN 1789
            DD+   +  +   +     + YYISPS++T+      +   V +LV+G K++GK++F+   ++ G+   S    I+ F     ++Y N    P  GEG+N  A+I  FN +P DKST +PI+D    +  +  E+L K+     + F SY  ++G + F V +
Sbjct:  949 DDKKAVFADVAEKDASFINENYYISPSLDTLSSYSLLQLRKVPHLVVGHKSYGKIEFLEPVDLAGIPLTSLGGVIITFEPKTCIIYANLPNRPKRGEGINVRARITCFNCYPVDKSTRKPIKDPNHQLVKRHIERLKKNP---NSKFESYDADSGTYVFIVNH 1108

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Yeast
Match: NUP100 (FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier and is involved in gene tethering at the nuclear periphery; NUP100 has a paralog, NUP116, that arose from the whole genome duplication [Source:SGD;Acc:S000001551])

HSP 1 Score: 73.9442 bits (180), Expect = 3.611e-14
Identity = 51/163 (31.29%), Postives = 85/163 (52.15%), Query Frame = 2

Query: 1325 SVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSI----VEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGAN----FISYTPENGEWAFEVE 1786
            S +   ++S++V   K+ YYISPSIET+      +   + NLVIG +N+GKV+F+   ++     D++    V F      +Y N  + P  GEG+N   ++ L++ FP DK T +PI++         H  L +  AK+  N    F SY P  G +++ ++
Sbjct:  799 SSKVPGLLSNDVTFFKNNYYISPSIETLGNKSLIELRKINNLVIGHRNYGKVEFLEPVDLLNTPLDTLCGDLVTFGPKSCSIYENCSIKPEKGEGINVRCRVTLYSCFPIDKETRKPIKNIT-------HPLLKRSIAKLKENPVYKFESYDPVTGTYSYTID 954

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Nematostella
Match: EDO41704 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S3D3])

HSP 1 Score: 78.1814 bits (191), Expect = 5.543e-15
Identity = 50/144 (34.72%), Postives = 73/144 (50.69%), Query Frame = 2

Query: 1364 LSKDGYYISPSIETIDKLVK-DKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
             S+  YY  PSIE ++ +V  + E WV++ VIGR+ +G+VKF G TNV  ++ D I +          N  LP     ++ L   +L         T  P    ERL +  + E++   +AK+GA FI Y P  G W F VE+F
Sbjct:    3 FSRPEYYTVPSIEQLNDMVDANGEVWVDDFVIGREGYGEVKFPGKTNVADLNLDEIGK----------NLCLPPCVSHVDPLTASLL---------TSTP----ERLKQQGWLERVEAATAKLGATFIDYQPHTGSWVFMVEHF 123

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Medaka
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:101172463])

HSP 1 Score: 125.946 bits (315), Expect = 1.621e-29
Identity = 60/149 (40.27%), Postives = 89/149 (59.73%), Query Frame = 2

Query: 1352 SNVKLSKDGYYISPSIETIDKLVKDK-ECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + L++ GYY  P +E +  +V +  EC VEN  +GRK +G + F G  N+  ++ D +V F   E +VYP+ +  P  GEGLN+ A++ L  V+P DK++   IR  ERL  M +  +L K S K GA F+ Y PE+G W FEV +F
Sbjct:  727 AGIVLNRVGYYTIPPLEDLADMVDENGECIVENFTVGRKGYGSIFFPGEVNLTNLNLDEVVHFRRKEVIVYPDDKNKPPEGEGLNRRAEVTLDGVWPNDKTSCTQIRSPERLADMNYEGRLEKASRKQGARFLEYRPESGSWVFEVNHF 875

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Medaka
Match: nup98 (nucleoporin 98 [Source:NCBI gene;Acc:101172463])

HSP 1 Score: 124.79 bits (312), Expect = 2.579e-29
Identity = 60/149 (40.27%), Postives = 90/149 (60.40%), Query Frame = 2

Query: 1352 SNVKLSKDGYYISPSIETIDKLV-KDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPN-QELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            + + L++ GYY  P +E +  +V ++ EC VEN  +GRK +G + F G  N+  ++ D +V F   E +VYP+ +  P  GEGLN+ A++ L  V+P DK++   IR  ERL  M +  +L K S K GA F+ Y PE+G W FEV +F
Sbjct:  688 AGIVLNRVGYYTIPPLEDLADMVDENGECIVENFTVGRKGYGSIFFPGEVNLTNLNLDEVVHFRRKEVIVYPDDKNKPPEGEGLNRRAEVTLDGVWPNDKTSCTQIRSPERLADMNYEGRLEKASRKQGARFLEYRPESGSWVFEVNHF 836

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Planmine SMEST
Match: SMESG000022300.1 (SMESG000022300.1)

HSP 1 Score: 517.694 bits (1332), Expect = 1.760e-173
Identity = 264/281 (93.95%), Postives = 267/281 (95.02%), Query Frame = 2

Query: 1001 KWLTEDVYQLI----------IHQENINPNTSEEEYLILSASQFMTEPKLNQCSTPLPGKIVLNKSQVSLNCERKTKKVVCFADSVNKHLETFKTIXXXXXXXXXXXXSANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENFLPSKTNV 1813
            K+L  D +Q +          IHQENINPNTSEEEYLILSASQFMTEPKLNQCSTPLPGKIVLNKSQVSLNCERKTKKVVCFADSVNKHLETFKTIEPYECEDEEDYESANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENFLPSKTNV
Sbjct:  667 KYLPADAFQKMVNRRRISTNNIHQENINPNTSEEEYLILSASQFMTEPKLNQCSTPLPGKIVLNKSQVSLNCERKTKKVVCFADSVNKHLETFKTIEPYECEDEEDYESANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQELPAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENFLPSKTNV 947

HSP 2 Score: 511.916 bits (1317), Expect = 3.128e-171
Identity = 350/372 (94.09%), Postives = 356/372 (95.70%), Query Frame = 1

Query:    1 PTNAFGGLGTNVHSQPNSIFGPNSQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPFSPSSTGKVAPVLLGNQTNTQSPVFGNSVNNFASNLNQPNTLXXXXXXXXXXXXXXXXXXXXXXYLGMNNQTNNSLITNQFGVNNFNSSIGSPFNISGNMQPNSVHERALEQQFLQNKVLQLVQNNPYGTNHLFMNKFSAIPSVLERAENPLPNQLVSEISPFQRRPIVKNSCKIRSNHIEKLFSGFDEENQSEETFFVKRTNWKYLSPDSFQRSRDNLDESRNKSFNEMNSSSGVSKKVENLKYLPADAFQKMVNRRRISTNN------SPGKYKS*YIRGRISYFISKP 1098
            PTNAFGGLGTNVHSQPNSIFGPNSQNTVIGQGNGGFGNNSQTGFGTNTQQNNLIGSNSINSSTGFFGNTNQTTGLGGSNLPFSPSSTGKVAPVLLGNQTNTQSPVFGNSVNNFASNLNQPNTLGTNSSMFGGGFNSNISGNSFQNYLGMNNQTNNSLITNQFGVNNFNSSIGSPFNISGNMQPNSVHERALEQQFLQNKVLQLVQNNPYGTNHLFMNKFSAIPSVLERAENPLPNQLVSEISPFQRRPIVKNSCKIRSNHIEKLFSGFDEENQSEETFFVKRTNWKYLSPDSFQRSRDNLDESRNKSFNEMNSSSGVSKKVENLKYLPADAFQKMVNRRRISTNN      +P   +  Y+    S F+++P
Sbjct:  343 PTNAFGGLGTNVHSQPNSIFGPNSQNTVIGQGNGGFGNNSQTGFGTNTQQNNLIGSNSINSSTGFFGNTNQTTGLGGSNLPFSPSSTGKVAPVLLGNQTNTQSPVFGNSVNNFASNLNQPNTLGTNSSMFGGGFNSNISGNSFQNYLGMNNQTNNSLITNQFGVNNFNSSIGSPFNISGNMQPNSVHERALEQQFLQNKVLQLVQNNPYGTNHLFMNKFSAIPSVLERAENPLPNQLVSEISPFQRRPIVKNSCKIRSNHIEKLFSGFDEENQSEETFFVKRTNWKYLSPDSFQRSRDNLDESRNKSFNEMNSSSGVSKKVENLKYLPADAFQKMVNRRRISTNNIHQENINPNTSEEEYLILSASQFMTEP 714

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Planmine SMEST
Match: SMESG000022283.1 (SMESG000022283.1)

HSP 1 Score: 149.828 bits (377), Expect = 1.662e-37
Identity = 73/157 (46.50%), Postives = 103/157 (65.61%), Query Frame = 2

Query: 1325 SVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S+  D   + ++ L+K+GYY SP+I+ +++LVK  EC+V++  I R  +G +KF G TNVYG++ D  V     E  VYPN ++ P  G+GLNK AQ+ L  +FP DKST E I++  RL  M F E++ K + K+GA FISY P NG W FEVE+F
Sbjct:  670 SINGDVADNCHIILTKEGYYTSPAIDKLNQLVKGTECYVQDFEIHRTGYGSIKFPGNTNVYGLNLDETVNILHKEVSVYPNDDIKPEEGDGLNKQAQVTLMGIFPTDKSTGEIIKEPIRLKTMNFEERIKKVTNKIGARFISYKPINGVWVFEVEHF 826

HSP 2 Score: 65.0846 bits (157), Expect = 1.400e-10
Identity = 42/118 (35.59%), Postives = 62/118 (52.54%), Query Frame = 1

Query:  595 KVLQLVQNNPYGTNHLFMNKFSAIPSVLERAENPL----PNQLVSEISPFQ------RRPIVKNSCKIRSNHIEKLFSGFDEENQSE------ETFFVKRTNWKYLSPDSFQRSRDNL 900
            KVL LV N PYG N LFM ++  + S L+   + +     N L   I   +      RR I+    KI    +  +FSGFDE+ +        ++F VKR +WKYL P++F++SR +L
Sbjct:  420 KVLSLVSNRPYGINKLFMGQY--MMSTLDTKTSGIDANNTNVLSVAIKRNEAEHVSNRRRILNQKTKINPCQVNNVFSGFDEDEELSIKSHKFDSFMVKREDWKYLPPNAFEKSRKSL 535

[Close]

BLAST of Peptidase S59 domain-containing protein vs. Planmine SMEST
Match: SMESG000022283.1 (SMESG000022283.1)

HSP 1 Score: 149.828 bits (377), Expect = 1.691e-37
Identity = 73/157 (46.50%), Postives = 103/157 (65.61%), Query Frame = 2

Query: 1325 SVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDKECWVENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQEL-PAIGEGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGANFISYTPENGEWAFEVENF 1792
            S+  D   + ++ L+K+GYY SP+I+ +++LVK  EC+V++  I R  +G +KF G TNVYG++ D  V     E  VYPN ++ P  G+GLNK AQ+ L  +FP DKST E I++  RL  M F E++ K + K+GA FISY P NG W FEVE+F
Sbjct:  670 SINGDVADNCHIILTKEGYYTSPAIDKLNQLVKGTECYVQDFEIHRTGYGSIKFPGNTNVYGLNLDETVNILHKEVSVYPNDDIKPEEGDGLNKQAQVTLMGIFPTDKSTGEIIKEPIRLKTMNFEERIKKVTNKIGARFISYKPINGVWVFEVEHF 826

HSP 2 Score: 65.0846 bits (157), Expect = 1.436e-10
Identity = 42/118 (35.59%), Postives = 62/118 (52.54%), Query Frame = 1

Query:  595 KVLQLVQNNPYGTNHLFMNKFSAIPSVLERAENPL----PNQLVSEISPFQ------RRPIVKNSCKIRSNHIEKLFSGFDEENQSE------ETFFVKRTNWKYLSPDSFQRSRDNL 900
            KVL LV N PYG N LFM ++  + S L+   + +     N L   I   +      RR I+    KI    +  +FSGFDE+ +        ++F VKR +WKYL P++F++SR +L
Sbjct:  420 KVLSLVSNRPYGINKLFMGQY--MMSTLDTKTSGIDANNTNVLSVAIKRNEAEHVSNRRRILNQKTKINPCQVNNVFSGFDEDEELSIKSHKFDSFMVKREDWKYLPPNAFEKSRKSL 535

The following BLAST results are available for this feature:

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Human
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Celegans
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Fly
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Zebrafish
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Xenopus
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Mouse
BLAST of Peptidase S59 domain-containing protein vs. UniProt/SwissProt
BLAST of Peptidase S59 domain-containing protein vs. TrEMBL
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Cavefish
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Sea Lamprey
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Yeast
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Nematostella
BLAST of Peptidase S59 domain-containing protein vs. Ensembl Medaka
BLAST of Peptidase S59 domain-containing protein vs. Planmine SMEST

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
NUP98	1.835e-24	36.20	nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068]	[more]
NUP98	1.923e-24	36.20	nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068]	[more]
NUP98	2.646e-24	36.20	nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068]	[more]
NUP98	3.001e-24	36.20	nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068]	[more]
NUP98	3.283e-24	36.20	nucleoporin 98 [Source:HGNC Symbol;Acc:HGNC:8068]	[more]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3


Match Name	E-value	Identity	Description
npp-10	3.796e-19	32.67	Nuclear pore complex protein Nup98-Nup96 Nuclear p...	[more]
npp-10	4.250e-19	32.67	Nuclear pore complex protein Nup98-Nup96 Nuclear p...	[more]
npp-10	4.445e-19	32.67	Nuclear pore complex protein Nup98-Nup96 Nuclear p...	[more]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3


Match Name	E-value	Identity	Description
Nup98-96	2.723e-26	38.93	gene:FBgn0039120 transcript:FBtr0304567	[more]
Nup98-96	4.424e-26	38.93	gene:FBgn0039120 transcript:FBtr0084460	[more]
Nup98-96	4.424e-26	38.93	gene:FBgn0039120 transcript:FBtr0334894	[more]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
nup98	1.760e-30	42.95	nucleoporin 98 [Source:ZFIN;Acc:ZDB-GENE-040426-11...	[more]
nup98	1.761e-30	42.95	nucleoporin 98 [Source:ZFIN;Acc:ZDB-GENE-040426-11...	[more]
nup98	1.763e-30	42.95	nucleoporin 98 [Source:ZFIN;Acc:ZDB-GENE-040426-11...	[more]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nup98	3.966e-28	38.37	nucleoporin 98 [Source:NCBI gene;Acc:100145055]	[more]
nup98	3.994e-28	38.37	nucleoporin 98 [Source:NCBI gene;Acc:100145055]	[more]
nup98	4.000e-28	38.37	nucleoporin 98 [Source:NCBI gene;Acc:100145055]	[more]
nup98	4.055e-28	38.37	nucleoporin 98 [Source:NCBI gene;Acc:100145055]	[more]
nup98	4.217e-28	38.37	nucleoporin 98 [Source:NCBI gene;Acc:100145055]	[more]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Nup98	1.337e-24	36.84	nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404]	[more]
Nup98	1.616e-24	36.84	nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404]	[more]
Nup98	1.683e-24	35.71	nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404]	[more]
Nup98	4.742e-24	35.71	nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404]	[more]
Nup98	5.218e-24	35.71	nucleoporin 98 [Source:MGI Symbol;Acc:MGI:109404]	[more]

BLAST of Peptidase S59 domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9VCH5\|NUP98_DROME	4.435e-25	38.93	Nuclear pore complex protein Nup98-Nup96 OS=Drosop...	[more]
sp\|Q6PFD9\|NUP98_MOUSE	1.023e-23	35.71	Nuclear pore complex protein Nup98-Nup96 OS=Mus mu...	[more]
sp\|P52948\|NUP98_HUMAN	1.441e-23	36.20	Nuclear pore complex protein Nup98-Nup96 OS=Homo s...	[more]
sp\|P49793\|NUP98_RAT	1.994e-23	35.12	Nuclear pore complex protein Nup98-Nup96 OS=Rattus...	[more]
sp\|Q8RY25\|NU98A_ARATH	1.808e-19	36.49	Nuclear pore complex protein NUP98A OS=Arabidopsis...	[more]

BLAST of Peptidase S59 domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A183JI73	7.359e-35	45.64	Peptidase S59 domain-containing protein OS=Schisto...	[more]
A0A3P8BCY2	7.799e-35	45.64	Peptidase S59 domain-containing protein OS=Schisto...	[more]
A0A3P8I966	5.981e-34	45.27	Peptidase S59 domain-containing protein OS=Echinos...	[more]
A0A183ARR2	6.259e-34	45.27	Peptidase S59 domain-containing protein OS=Echinos...	[more]
A0A430Q4N3	1.628e-33	45.64	Nuclear pore complex protein Nup98-Nup96 (Fragment...	[more]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
nup98	7.151e-31	42.95	nucleoporin 98 [Source:NCBI gene;Acc:103032416]	[more]
nup98	7.387e-31	42.95	nucleoporin 98 [Source:NCBI gene;Acc:103032416]	[more]
nup98	7.772e-31	42.95	nucleoporin 98 [Source:NCBI gene;Acc:103032416]	[more]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSPMAT00000010326.1	5.369e-33	40.27	pep scaffold:Pmarinus_7.0:GL476446:469078:484887:-...	[more]
ENSPMAT00000002346.1	1.077e-25	36.24	pep scaffold:Pmarinus_7.0:GL477945:9692:37886:-1 g...	[more]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 3


Match Name	E-value	Identity	Description
NUP145	1.065e-17	34.64	Essential protein with distinct roles in two nucle...	[more]
NUP116	1.766e-15	30.06	FG-nucleoporin component of central core of the nu...	[more]
NUP100	3.611e-14	31.29	FG-nucleoporin component of central core of the nu...	[more]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO41704	5.543e-15	34.72	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Peptidase S59 domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
nup98	1.621e-29	40.27	nucleoporin 98 [Source:NCBI gene;Acc:101172463]	[more]
nup98	2.579e-29	40.27	nucleoporin 98 [Source:NCBI gene;Acc:101172463]	[more]

BLAST of Peptidase S59 domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3


Match Name	E-value	Identity	Description
SMESG000022300.1	1.760e-173	93.95	SMESG000022300.1	[more]
SMESG000022283.1	1.662e-37	46.50	SMESG000022283.1	[more]
SMESG000022283.1	1.691e-37	46.50	SMESG000022283.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence
protein sequence

transcript sequence

>SMED30024965 ID=SMED30024965|Name=Peptidase S59 domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1814bp
CCAACTAATGCTTTTGGTGGCCTAGGAACCAATGTTCATTCACAGCCGAA
TTCGATATTTGGTCCTAATAGCCAGAATACTGTAATTGGACAAGGTAATG
GCGGTTTTGGAAATAATTCTCAAACTGGTTTTGGAACAAATACCCAACAG
AATAATTTAATTGGTTCAAATAGTATTAACTCTTCAACTGGTTTCTTCGG
AAATACCAACCAGACAACCGGATTAGGAGGTTCTAATTTGCCATTTAGCC
CTTCAAGCACGGGAAAAGTGGCTCCTGTCTTATTGGGAAATCAGACAAAT
ACTCAATCACCTGTGTTTGGCAATTCCGTAAACAATTTTGCTTCAAATCT
CAATCAACCGAATACACTTGGAACAAATTCATCAATGTTTGGAGGCGGGT
TTAATAGTAATATTTCCGGAAATTCTTTTCAAAATTATTTAGGAATGAAT
AATCAAACAAATAATTCCTTAATTACTAACCAATTTGGTGTTAATAATTT
CAATTCCTCCATCGGATCTCCTTTCAATATCTCAGGAAACATGCAACCTA
ACTCAGTACATGAGAGAGCTTTAGAGCAACAATTTCTACAAAATAAGGTT
CTTCAACTTGTTCAAAATAATCCTTATGGAACCAATCATTTATTTATGAA
CAAATTCTCTGCAATACCAAGTGTATTAGAAAGAGCGGAAAATCCCCTAC
CAAACCAGCTAGTCAGTGAAATAAGTCCTTTTCAAAGACGACCCATTGTC
AAAAATAGTTGTAAAATTCGTTCGAATCATATTGAAAAATTATTCAGTGG
ATTTGATGAAGAAAATCAGTCTGAAGAAACATTTTTCGTCAAACGAACCA
ATTGGAAGTATTTATCTCCAGATTCATTTCAAAGGAGTCGTGATAATTTA
GATGAGTCTAGAAACAAATCTTTTAATGAAATGAATAGCAGTTCTGGAGT
CAGTAAAAAAGTTGAAAATTTAAAATACTTGCCAGCAGATGCTTTTCAAA
AAATGGTTAACAGAAGACGTATATCAACTAATAATTCACCAGGAAAATAT
AAATCCTAATACATCCGAGGAAGAATATCTTATTTTATCAGCAAGCCAAT
TTATGACCGAACCAAAATTGAATCAGTGTTCAACCCCTTTGCCAGGGAAA
ATAGTTCTAAACAAATCACAAGTTTCACTTAATTGCGAAAGAAAGACAAA
AAAGGTAGTTTGTTTTGCAGATTCGGTCAATAAACACCTTGAAACCTTTA
AGACAATTGAACCCTATGAATGCGAAGATGAGGAAGATTATGAATCTGCA
AACGACGATTTTAGTGACGATCAATCCGTTGAATATGATTCAATTATAAG
TTCAAATGTTAAACTGAGTAAAGATGGGTACTACATATCTCCAAGCATTG
AAACAATTGATAAATTAGTTAAAGATAAAGAATGTTGGGTTGAAAATTTA
GTGATAGGACGAAAAAATTTCGGAAAAGTAAAATTTGTTGGTCTAACCAA
TGTCTATGGAATGGATTTCGACAGTATAGTAGAATTTAATGAAAATGAAT
TCGTAGTTTATCCCAATCAAGAACTGCCAGCAATCGGCGAAGGCTTGAAC
AAGTTAGCTCAGATCGTTTTGTTTAATGTGTTTCCAAAGGATAAATCGAC
TGAAGAACCAATTCGGGATTGCGAGCGTTTGGTAAAAATGAAGTTTCATG
AAAAATTAGCAAAACATTCAGCAAAAGTTGGCGCAAATTTTATAAGTTAC
ACACCTGAAAACGGGGAGTGGGCATTTGAAGTTGAAAATTTTTTGCCTTC
AAAAACCAATGTTG

protein sequence of SMED30024965-orf-1

>SMED30024965-orf-1 ID=SMED30024965-orf-1|Name=SMED30024965-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=275bp
MLFKKWLTEDVYQLIIHQENINPNTSEEEYLILSASQFMTEPKLNQCSTP
LPGKIVLNKSQVSLNCERKTKKVVCFADSVNKHLETFKTIEPYECEDEED
YESANDDFSDDQSVEYDSIISSNVKLSKDGYYISPSIETIDKLVKDKECW
VENLVIGRKNFGKVKFVGLTNVYGMDFDSIVEFNENEFVVYPNQELPAIG
EGLNKLAQIVLFNVFPKDKSTEEPIRDCERLVKMKFHEKLAKHSAKVGAN
FISYTPENGEWAFEVENFLPSKTNV

protein sequence of SMED30024965-orf-2

>SMED30024965-orf-2 ID=SMED30024965-orf-2|Name=SMED30024965-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=353bp
PTNAFGGLGTNVHSQPNSIFGPNSQNTVIGQGNGGFGNNSQTGFGTNTQQ
NNLIGSNSINSSTGFFGNTNQTTGLGGSNLPFSPSSTGKVAPVLLGNQTN
TQSPVFGNSVNNFASNLNQPNTLGTNSSMFGGGFNSNISGNSFQNYLGMN
NQTNNSLITNQFGVNNFNSSIGSPFNISGNMQPNSVHERALEQQFLQNKV
LQLVQNNPYGTNHLFMNKFSAIPSVLERAENPLPNQLVSEISPFQRRPIV
KNSCKIRSNHIEKLFSGFDEENQSEETFFVKRTNWKYLSPDSFQRSRDNL
DESRNKSFNEMNSSSGVSKKVENLKYLPADAFQKMVNRRRISTNNSPGKY
KS*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **biological process**
Term	Definition
GO:0006913	nucleocytoplasmic transport
GO:0006810	transport

Vocabulary: **molecular function**
Term	Definition
GO:0017056	structural constituent of nuclear pore

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000074	oocyte
PLANA:0000231	vitelline gland

Vocabulary: **INTERPRO**
Term	Definition
IPR007230	Peptidase_S59

Vocabulary: **cellular component**
Term	Definition
GO:0005643	nuclear pore

Main menu

Peptidase S59 domain-containing protein

Zeng et. al., 2018

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Owlery

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