Rap guanine nucleotide exchange factor 2

Overview


Name	Rap guanine nucleotide exchange factor 2
Smed ID	SMED30024929
Length (bp)	4980

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Rap guanine nucleotide exchange factor 2 (SMED30024929) t-SNE clustered cells

Violin plots show distribution of expression levels for Rap guanine nucleotide exchange factor 2 (SMED30024929) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Rap guanine nucleotide exchange factor 2 (SMED30024929) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Rap guanine nucleotide exchange factor 2 (SMED30024929) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30024929

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
protonephridia	SMED30024929	SMESG000033489.1 SMESG000033486.1	dd_Smed_v4_4950_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30024929	SMESG000033489.1 SMESG000033486.1	dd_Smed_v4_4950_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30024929	SMESG000033489.1 SMESG000033486.1	dd_Smed_v4_4950_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30024929	SMESG000033489.1 SMESG000033486.1	dd_Smed_v4_4950_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30024929	SMESG000033489.1 SMESG000033486.1	dd_Smed_v4_4950_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Human
Match: RAPGEF2 (Rap guanine nucleotide exchange factor 2 [Source:HGNC Symbol;Acc:HGNC:16854])

HSP 1 Score: 248.44 bits (633), Expect = 9.543e-66
Identity = 145/362 (40.06%), Postives = 217/362 (59.94%), Query Frame = 3

Query: 2289 STSNPDL-KAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            S+SNPDL ++H    + S   +     +QVL+V++ +    +Y++I+ +TTAKEVV   I+EF++  +    YSL  V+V       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  +E+AT+L++ ++ LFR+I   EYI+ +FKL                              N K FE++IN+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PV+RL+ TWEK+PNKY KL++DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  583 SSSNPDLLQSHHRILDFSATPD---LPDQVLRVFKADQ-QSRYIMISKDTTAKEVVIQAIREFAVTATP-DQYSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCA-----------------------NLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 912

HSP 2 Score: 238.424 bits (607), Expect = 1.037e-62
Identity = 140/393 (35.62%), Postives = 224/393 (57.00%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYS-IGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI---GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEILDYFSD 1850
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +G  +    G+SFGV P M+++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP +IE+FLLTYR F+ SP  +  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE+   N+E   +G    +   AC++ +K R +TL      SR  P   I   G +KG+G+F+  ++  ++    GL+RGDQIL +   ++E I+ L KA ++L  NT+ SI   V+ N   F E+L   S+
Sbjct:  105 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFN-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFEN---NLEREKMGGHLRLLNIACAAKAKRRLMTL---TKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQ-LSKAMEILRNNTHLSI--TVKTNLFVFKELLTRLSE 479

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Human
Match: RAPGEF2 (Rap guanine nucleotide exchange factor 2 [Source:HGNC Symbol;Acc:HGNC:16854])

HSP 1 Score: 248.054 bits (632), Expect = 1.198e-65
Identity = 145/362 (40.06%), Postives = 217/362 (59.94%), Query Frame = 3

Query: 2289 STSNPDL-KAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            S+SNPDL ++H    + S   +     +QVL+V++ +    +Y++I+ +TTAKEVV   I+EF++  +    YSL  V+V       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  +E+AT+L++ ++ LFR+I   EYI+ +FKL                              N K FE++IN+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PV+RL+ TWEK+PNKY KL++DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  626 SSSNPDLLQSHHRILDFSATPD---LPDQVLRVFKADQ-QSRYIMISKDTTAKEVVIQAIREFAVTATP-DQYSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCA-----------------------NLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 955

HSP 2 Score: 238.424 bits (607), Expect = 1.473e-62
Identity = 140/393 (35.62%), Postives = 224/393 (57.00%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYS-IGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI---GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEILDYFSD 1850
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +G  +    G+SFGV P M+++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP +IE+FLLTYR F+ SP  +  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE+   N+E   +G    +   AC++ +K R +TL      SR  P   I   G +KG+G+F+  ++  ++    GL+RGDQIL +   ++E I+ L KA ++L  NT+ SI   V+ N   F E+L   S+
Sbjct:  148 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFN-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFEN---NLEREKMGGHLRLLNIACAAKAKRRLMTL---TKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQ-LSKAMEILRNNTHLSI--TVKTNLFVFKELLTRLSE 522

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Human
Match: RAPGEF2 (Rap guanine nucleotide exchange factor 2 [Source:HGNC Symbol;Acc:HGNC:16854])

HSP 1 Score: 248.44 bits (633), Expect = 1.346e-65
Identity = 145/362 (40.06%), Postives = 217/362 (59.94%), Query Frame = 3

Query: 2289 STSNPDL-KAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            S+SNPDL ++H    + S   +     +QVL+V++ +    +Y++I+ +TTAKEVV   I+EF++  +    YSL  V+V       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  +E+AT+L++ ++ LFR+I   EYI+ +FKL                              N K FE++IN+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PV+RL+ TWEK+PNKY KL++DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  738 SSSNPDLLQSHHRILDFSATPD---LPDQVLRVFKADQ-QSRYIMISKDTTAKEVVIQAIREFAVTATP-DQYSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCA-----------------------NLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 1067

HSP 2 Score: 238.039 bits (606), Expect = 2.079e-62
Identity = 140/393 (35.62%), Postives = 224/393 (57.00%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYS-IGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI---GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEILDYFSD 1850
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +G  +    G+SFGV P M+++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP +IE+FLLTYR F+ SP  +  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE+   N+E   +G    +   AC++ +K R +TL      SR  P   I   G +KG+G+F+  ++  ++    GL+RGDQIL +   ++E I+ L KA ++L  NT+ SI   V+ N   F E+L   S+
Sbjct:  260 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFN-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFEN---NLEREKMGGHLRLLNIACAAKAKRRLMTL---TKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQ-LSKAMEILRNNTHLSI--TVKTNLFVFKELLTRLSE 634

HSP 3 Score: 105.916 bits (263), Expect = 5.712e-22
Identity = 48/117 (41.03%), Postives = 70/117 (59.83%), Query Frame = 3

Query:   33 DDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDY 383
            D+ F + +   P  RT QD+  + SY   +EAL + +E  +       RYE ++ N  LY   D+ T WYI+LSG V + ++MF PR+SFG RS G+  R  EC++LE +E+IV DY
Sbjct:    6 DNSFRQAVMKNPPERTPQDLEIVYSYLHGMEALSNLREHQLRLMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSFRRGCECIVLEPSEMIVVDY 122

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Human
Match: RAPGEF6 (Rap guanine nucleotide exchange factor 6 [Source:HGNC Symbol;Acc:HGNC:20655])

HSP 1 Score: 237.269 bits (604), Expect = 7.110e-63
Identity = 143/379 (37.73%), Postives = 221/379 (58.31%), Query Frame = 3

Query: 2289 STSNPDLKAHEECTNDSLMRENQTTV-NQVLKVYRPNSVDFK--YVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNR 3416
            S+S+PDL    + T   L   N + + +QV++V++   VD +  Y++I+ +TTAKEVV   + EF +  +    YSL  V+V       +IK  R+   F  LA ++ LN RYYLKNN+    L +DE A+ L+ ES++++ Q+  IE+AT+L++ D+ LFR+I   EYI+ +FKL                           G  + K FED++N+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L  V+RL+ TWEK+P+KY K  +DL D+ D S N  + R ++  +  +PP+IP   +  KD+  +H GN +   D L+NFEKLRM++ EIR+++RM +   +   +    K R
Sbjct:  441 SSSSPDLL---QPTTSMLDFSNPSDIPDQVIRVFK---VDQQSCYIIISKDTTAKEVVFHAVHEFGLTGAS-DTYSLCEVSVTPE---GVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNS-----------------------KTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKV-DGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRKKR 785

HSP 2 Score: 198.364 bits (503), Expect = 1.236e-50
Identity = 120/360 (33.33%), Postives = 203/360 (56.39%), Query Frame = 3

Query:  804 KYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEP-QDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIE-YSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI---GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEILDYFSDAESGI 1865
            + E+C VM   +V  +   ++EDGQ +D+W V+LNGTVE+   +G ++    G+SFG+ P +++Q   G + T    C F C+ Q  +  I++ +++    + EE G+I +V+E R L    +  G +V+K T ++LI  L+ +    DP YIE+FLLTYR F++SP  +  KLL+ ++ +  +DK       + +I++LW NNHF D + DP   M  +LEEFE    N+E   +     +   AC++ +K R + L+     SR +P +     G +KG+G+F++ +   ++    GL+RGDQI+ +   ++E I T  KA ++L  NT+  + L V+ N   F E+L      +SG+
Sbjct:    4 RRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILN-HVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDK-------VTRIVLLWVNNHFNDFEGDPA--MTRFLEEFE---KNLEDTKMNGHLRLLNIACAAKAKWRQVVLQ---KASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENI-TFMKAVEILRNNTH--LALTVKTNIFVFKELLFRTEQEKSGV 344

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Human
Match: RAPGEF6 (Rap guanine nucleotide exchange factor 6 [Source:HGNC Symbol;Acc:HGNC:20655])

HSP 1 Score: 235.728 bits (600), Expect = 4.055e-62
Identity = 141/365 (38.63%), Postives = 217/365 (59.45%), Query Frame = 3

Query: 2289 STSNPDLKAHEECTNDSLMRENQTTV-NQVLKVYRPNSVDFK--YVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNT 3374
            S+S+PDL    + T   L   N + + +QV++V++   VD +  Y++I+ +TTAKEVV   + EF +  +    YSL  V+V       +IK  R+   F  LA ++ LN RYYLKNN+    L +DE A+ L+ ES++++ Q+  IE+AT+L++ D+ LFR+I   EYI+ +FKL                           G  + K FED++N+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L  V+RL+ TWEK+P+KY K  +DL D+ D S N  + R ++  +  +PP+IP   +  KD+  +H GN +   D L+NFEKLRM++ EIR+++RM + 
Sbjct:  392 SSSSPDLL---QPTTSMLDFSNPSDIPDQVIRVFK---VDQQSCYIIISKDTTAKEVVFHAVHEFGLTGAS-DTYSLCEVSVTPE---GVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNS-----------------------KTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKV-DGLVNFEKLRMISKEIRQVVRMTSA 722

HSP 2 Score: 137.887 bits (346), Expect = 8.630e-32
Identity = 92/281 (32.74%), Postives = 157/281 (55.87%), Query Frame = 3

Query: 1041 FCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEP-QDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYS-IGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI---GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEILDYFSDAESGI 1865
            F C+ Q  +  I++ +++    + EE G+I +V+E R L    +  G +V+K T ++LI  L+ +    DP YIE+FLLTYR F++SP  +  KLL+ ++ +  +DK       + +I++LW NNHF D + DP   M  +LEEFE    N+E + +     +   AC++ +K R + L+     SR +P +     G +KG+G+F++ +   ++    GL+RGDQI+ +   ++E I T  KA ++L  NT+  + L V+ N   F E+L      +SG+
Sbjct:   34 FVCIAQQDYWRILN-HVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDK-------VTRIVLLWVNNHFNDFEGDPA--MTRFLEEFE---KNLEDTKMNGHLRLLNIACAAKAKWRQVVLQ---KASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENI-TFMKAVEILRNNTH--LALTVKTNIFVFKELLFRTEQEKSGV 295

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BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Celegans
Match: pxf-1 (Rap guanine nucleotide exchange factor [Source:UniProtKB/Swiss-Prot;Acc:G5EDB9])

HSP 1 Score: 228.024 bits (580), Expect = 5.581e-60
Identity = 131/344 (38.08%), Postives = 199/344 (57.85%), Query Frame = 3

Query: 2370 QVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLY--TVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSI 3395
             VLK+YR N   FKY+ +   T+A+ VV L ++EF++       +SL   TVT+D      +IK  R+    ++LA +++LN RYYLKNN     L+ DE A  LL E++  L  +    +A +LTL D+++F  I   E+++ +FKL                D K        G    + FE L NRE +W  TEIC E ++ KRA+LIKKFIKVA++C+DL+NFNS+  I++GL    V RL  +WE+V +KYI++ +++  L D S N  + RQ +     EPP++P   +  KDL   H GN T + ++LINFEKLR++A  IR ++++ +  Y + S+
Sbjct:  661 HVLKIYR-NDQTFKYLPVYKETSAQNVVQLALQEFNMTAEGSPEWSLCECTVTIDG-----VIKQRRLPPQMENLAERIALNSRYYLKNNSRSEPLVPDELAPELLKEAQTQLLSLNAQVVAAQLTLQDFSVFSAIEPTEFLDNLFKL----------------DSKY-------GSPKLEEFEQLFNREMWWVATEICTERHVQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLHSSWERVSSKYIRMLDEIHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDGNATYS-EKLINFEKLRLIAKSIRGVMKLSSAPYEIASM 974

HSP 2 Score: 189.504 bits (480), Expect = 4.524e-48
Identity = 119/363 (32.78%), Postives = 191/363 (52.62%), Query Frame = 3

Query:  681 MSDTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKY--DPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLDDPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLIGLQK-GWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATD 1760
            + D+  + + KEP+ RN  D+  +LD +QH+ AF       K ++C  M   +V+++   ++   + +D+W+V++NG VEV   +G   EY  GDSFG +P    Q H GEM T+   C F  V    FC I+S   D I  E++  G    V  E    +  ++ G+V++KG  DKLI  L VD+R +  DP Y+++FLLTYRVF++ P  I +KL+  +       DS  +  + ++++LW NNHF D +  N +M   LE FE         +    S+   ACS  +KPR + L   K+       RL+G Q+ G  +++ E+   T     G++R D++L +   S + + +  KA D
Sbjct:  192 LRDSVRECLEKEPSERNSEDLAVLLDFMQHMSAFAALPMSIKRQLCLKMVFAVVNDAGTVVLAHNEKLDSWSVIVNGCVEVVKPSGERVEYKLGDSFGAEPTPATQIHIGEMRTMVDDCEFVLVEHRDFCSIMSTIGDHI--EKDRDGLTGEVVSEVERRTVGTHCGQVLIKGKPDKLIHHL-VDERDHNVDPHYVDDFLLTYRVFIRDPTTIFEKLMLWF------ADSIYRDKVARLVLLWVNNHFNDFET-NDEMWNLLERFEGALE--RDGMHSQLSLLNIACSVKAKPRQVILTRRKD--DKMMMRLVGGQESGNSVYVAEVFPDTSAAREGVKRADEMLEVNQQSAKYL-SAKKAED 539

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Query: 2370 QVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLY--TVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSI 3395
             VLK+YR N   FKY+ +   T+A+ VV L ++EF++       +SL   TVT+D      +IK  R+    ++LA +++LN RYYLKNN     L+ DE A  LL E++  L  +    +A +LTL D+++F  I   E+++ +FKL                D K        G    + FE L NRE +W  TEIC E ++ KRA+LIKKFIKVA++C+DL+NFNS+  I++GL    V RL  +WE+V +KYI++ +++  L D S N  + RQ +     EPP++P   +  KDL   H GN T + ++LINFEKLR++A  IR ++++ +  Y + S+
Sbjct:  661 HVLKIYR-NDQTFKYLPVYKETSAQNVVQLALQEFNMTAEGSPEWSLCECTVTIDG-----VIKQRRLPPQMENLAERIALNSRYYLKNNSRSEPLVPDELAPELLKEAQTQLLSLNAQVVAAQLTLQDFSVFSAIEPTEFLDNLFKL----------------DSKY-------GSPKLEEFEQLFNREMWWVATEICTERHVQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLHSSWERVSSKYIRMLDEIHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDGNATYS-EKLINFEKLRLIAKSIRGVMKLSSAPYEIASM 974

HSP 2 Score: 189.504 bits (480), Expect = 4.524e-48
Identity = 119/363 (32.78%), Postives = 191/363 (52.62%), Query Frame = 3

Query:  681 MSDTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKY--DPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLDDPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLIGLQK-GWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATD 1760
            + D+  + + KEP+ RN  D+  +LD +QH+ AF       K ++C  M   +V+++   ++   + +D+W+V++NG VEV   +G   EY  GDSFG +P    Q H GEM T+   C F  V    FC I+S   D I  E++  G    V  E    +  ++ G+V++KG  DKLI  L VD+R +  DP Y+++FLLTYRVF++ P  I +KL+  +       DS  +  + ++++LW NNHF D +  N +M   LE FE         +    S+   ACS  +KPR + L   K+       RL+G Q+ G  +++ E+   T     G++R D++L +   S + + +  KA D
Sbjct:  192 LRDSVRECLEKEPSERNSEDLAVLLDFMQHMSAFAALPMSIKRQLCLKMVFAVVNDAGTVVLAHNEKLDSWSVIVNGCVEVVKPSGERVEYKLGDSFGAEPTPATQIHIGEMRTMVDDCEFVLVEHRDFCSIMSTIGDHI--EKDRDGLTGEVVSEVERRTVGTHCGQVLIKGKPDKLIHHL-VDERDHNVDPHYVDDFLLTYRVFIRDPTTIFEKLMLWF------ADSIYRDKVARLVLLWVNNHFNDFET-NDEMWNLLERFEGALE--RDGMHSQLSLLNIACSVKAKPRQVILTRRKD--DKMMMRLVGGQESGNSVYVAEVFPDTSAAREGVKRADEMLEVNQQSAKYL-SAKKAED 539

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Celegans
Match: pxf-1 (Rap guanine nucleotide exchange factor [Source:UniProtKB/Swiss-Prot;Acc:G5EDB9])

HSP 1 Score: 227.639 bits (579), Expect = 6.602e-60
Identity = 129/344 (37.50%), Postives = 197/344 (57.27%), Query Frame = 3

Query: 2370 QVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLY--TVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSI 3395
             VLK+YR N   FKY+ +   T+A+ VV L ++EF++       +SL   TVT+D      +IK  R+    ++LA +++LN RYYLKNN     L+ DE A  LL E++  L  +    +A +LTL D+++F  I   E+++ +FKL                           G    + FE L NRE +W  TEIC E ++ KRA+LIKKFIKVA++C+DL+NFNS+  I++GL    V RL  +WE+V +KYI++ +++  L D S N  + RQ +     EPP++P   +  KDL   H GN T + ++LINFEKLR++A  IR ++++ +  Y + S+
Sbjct:  619 HVLKIYR-NDQTFKYLPVYKETSAQNVVQLALQEFNMTAEGSPEWSLCECTVTIDG-----VIKQRRLPPQMENLAERIALNSRYYLKNNSRSEPLVPDELAPELLKEAQTQLLSLNAQVVAAQLTLQDFSVFSAIEPTEFLDNLFKLDSKY-----------------------GSPKLEEFEQLFNREMWWVATEICTERHVQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLHSSWERVSSKYIRMLDEIHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDGNATYS-EKLINFEKLRLIAKSIRGVMKLSSAPYEIASM 932

HSP 2 Score: 189.119 bits (479), Expect = 4.977e-48
Identity = 116/351 (33.05%), Postives = 185/351 (52.71%), Query Frame = 3

Query:  681 MSDTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKY--DPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLDDPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLIGLQK-GWGLFIKEINRLTQRKTFGLRRGDQILSLANHS 1724
            + D+  + + KEP+ RN  D+  +LD +QH+ AF       K ++C  M   +V+++   ++   + +D+W+V++NG VEV   +G   EY  GDSFG +P    Q H GEM T+   C F  V    FC I+S   D I  E++  G    V  E    +  ++ G+V++KG  DKLI  L VD+R +  DP Y+++FLLTYRVF++ P  I +KL+  +       DS  +  + ++++LW NNHF D +  N +M   LE FE         +    S+   ACS  +KPR + L   K+       RL+G Q+ G  +++ E+   T     G++R D++L +   S
Sbjct:  150 LRDSVRECLEKEPSERNSEDLAVLLDFMQHMSAFAALPMSIKRQLCLKMVFAVVNDAGTVVLAHNEKLDSWSVIVNGCVEVVKPSGERVEYKLGDSFGAEPTPATQIHIGEMRTMVDDCEFVLVEHRDFCSIMSTIGDHI--EKDRDGLTGEVVSEVERRTVGTHCGQVLIKGKPDKLIHHL-VDERDHNVDPHYVDDFLLTYRVFIRDPTTIFEKLMLWF------ADSIYRDKVARLVLLWVNNHFNDFET-NDEMWNLLERFEGALE--RDGMHSQLSLLNIACSVKAKPRQVILTRRKD--DKMMMRLVGGQESGNSVYVAEVFPDTSAAREGVKRADEMLEVNQQS 486

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Celegans
Match: pxf-1 (Rap guanine nucleotide exchange factor [Source:UniProtKB/Swiss-Prot;Acc:G5EDB9])

HSP 1 Score: 227.639 bits (579), Expect = 6.602e-60
Identity = 129/344 (37.50%), Postives = 197/344 (57.27%), Query Frame = 3

Query: 2370 QVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLY--TVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSI 3395
             VLK+YR N   FKY+ +   T+A+ VV L ++EF++       +SL   TVT+D      +IK  R+    ++LA +++LN RYYLKNN     L+ DE A  LL E++  L  +    +A +LTL D+++F  I   E+++ +FKL                           G    + FE L NRE +W  TEIC E ++ KRA+LIKKFIKVA++C+DL+NFNS+  I++GL    V RL  +WE+V +KYI++ +++  L D S N  + RQ +     EPP++P   +  KDL   H GN T + ++LINFEKLR++A  IR ++++ +  Y + S+
Sbjct:  619 HVLKIYR-NDQTFKYLPVYKETSAQNVVQLALQEFNMTAEGSPEWSLCECTVTIDG-----VIKQRRLPPQMENLAERIALNSRYYLKNNSRSEPLVPDELAPELLKEAQTQLLSLNAQVVAAQLTLQDFSVFSAIEPTEFLDNLFKLDSKY-----------------------GSPKLEEFEQLFNREMWWVATEICTERHVQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLHSSWERVSSKYIRMLDEIHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDGNATYS-EKLINFEKLRLIAKSIRGVMKLSSAPYEIASM 932

HSP 2 Score: 189.119 bits (479), Expect = 4.977e-48
Identity = 116/351 (33.05%), Postives = 185/351 (52.71%), Query Frame = 3

Query:  681 MSDTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKY--DPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLDDPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLIGLQK-GWGLFIKEINRLTQRKTFGLRRGDQILSLANHS 1724
            + D+  + + KEP+ RN  D+  +LD +QH+ AF       K ++C  M   +V+++   ++   + +D+W+V++NG VEV   +G   EY  GDSFG +P    Q H GEM T+   C F  V    FC I+S   D I  E++  G    V  E    +  ++ G+V++KG  DKLI  L VD+R +  DP Y+++FLLTYRVF++ P  I +KL+  +       DS  +  + ++++LW NNHF D +  N +M   LE FE         +    S+   ACS  +KPR + L   K+       RL+G Q+ G  +++ E+   T     G++R D++L +   S
Sbjct:  150 LRDSVRECLEKEPSERNSEDLAVLLDFMQHMSAFAALPMSIKRQLCLKMVFAVVNDAGTVVLAHNEKLDSWSVIVNGCVEVVKPSGERVEYKLGDSFGAEPTPATQIHIGEMRTMVDDCEFVLVEHRDFCSIMSTIGDHI--EKDRDGLTGEVVSEVERRTVGTHCGQVLIKGKPDKLIHHL-VDERDHNVDPHYVDDFLLTYRVFIRDPTTIFEKLMLWF------ADSIYRDKVARLVLLWVNNHFNDFET-NDEMWNLLERFEGALE--RDGMHSQLSLLNIACSVKAKPRQVILTRRKD--DKMMMRLVGGQESGNSVYVAEVFPDTSAAREGVKRADEMLEVNQQS 486

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Celegans
Match: pxf-1 (Rap guanine nucleotide exchange factor [Source:UniProtKB/Swiss-Prot;Acc:G5EDB9])

HSP 1 Score: 226.868 bits (577), Expect = 8.399e-60
Identity = 129/344 (37.50%), Postives = 197/344 (57.27%), Query Frame = 3

Query: 2370 QVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLY--TVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSI 3395
             VLK+YR N   FKY+ +   T+A+ VV L ++EF++       +SL   TVT+D      +IK  R+    ++LA +++LN RYYLKNN     L+ DE A  LL E++  L  +    +A +LTL D+++F  I   E+++ +FKL                           G    + FE L NRE +W  TEIC E ++ KRA+LIKKFIKVA++C+DL+NFNS+  I++GL    V RL  +WE+V +KYI++ +++  L D S N  + RQ +     EPP++P   +  KDL   H GN T + ++LINFEKLR++A  IR ++++ +  Y + S+
Sbjct:  661 HVLKIYR-NDQTFKYLPVYKETSAQNVVQLALQEFNMTAEGSPEWSLCECTVTIDG-----VIKQRRLPPQMENLAERIALNSRYYLKNNSRSEPLVPDELAPELLKEAQTQLLSLNAQVVAAQLTLQDFSVFSAIEPTEFLDNLFKLDSKY-----------------------GSPKLEEFEQLFNREMWWVATEICTERHVQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLHSSWERVSSKYIRMLDEIHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDGNATYS-EKLINFEKLRLIAKSIRGVMKLSSAPYEIASM 974

HSP 2 Score: 189.119 bits (479), Expect = 4.439e-48
Identity = 116/351 (33.05%), Postives = 185/351 (52.71%), Query Frame = 3

Query:  681 MSDTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKY--DPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLDDPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLIGLQK-GWGLFIKEINRLTQRKTFGLRRGDQILSLANHS 1724
            + D+  + + KEP+ RN  D+  +LD +QH+ AF       K ++C  M   +V+++   ++   + +D+W+V++NG VEV   +G   EY  GDSFG +P    Q H GEM T+   C F  V    FC I+S   D I  E++  G    V  E    +  ++ G+V++KG  DKLI  L VD+R +  DP Y+++FLLTYRVF++ P  I +KL+  +       DS  +  + ++++LW NNHF D +  N +M   LE FE         +    S+   ACS  +KPR + L   K+       RL+G Q+ G  +++ E+   T     G++R D++L +   S
Sbjct:  192 LRDSVRECLEKEPSERNSEDLAVLLDFMQHMSAFAALPMSIKRQLCLKMVFAVVNDAGTVVLAHNEKLDSWSVIVNGCVEVVKPSGERVEYKLGDSFGAEPTPATQIHIGEMRTMVDDCEFVLVEHRDFCSIMSTIGDHI--EKDRDGLTGEVVSEVERRTVGTHCGQVLIKGKPDKLIHHL-VDERDHNVDPHYVDDFLLTYRVFIRDPTTIFEKLMLWF------ADSIYRDKVARLVLLWVNNHFNDFET-NDEMWNLLERFEGALER--DGMHSQLSLLNIACSVKAKPRQVILTRRKD--DKMMMRLVGGQESGNSVYVAEVFPDTSAAREGVKRADEMLEVNQQS 528

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Fly
Match: PDZ-GEF (gene:FBgn0265778 transcript:FBtr0300039)

HSP 1 Score: 261.151 bits (666), Expect = 3.599e-70
Identity = 165/453 (36.42%), Postives = 245/453 (54.08%), Query Frame = 3

Query: 2367 NQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPE-ISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPNFNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFAXXXXXXXXXXXXXSLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSV 3722
            + VLKVY+ +    KYVLI   TTA EVV L ++EF I     +N+SL  V+V    +G ++K  R+    ++LA ++S   RYYLK N +   L+ DE A  L+ ES V    +   E+A +LTL D+A FR I S EY++ +F                  + +S       G      F +L+NRE FW  +EIC E NI +R +++K+FIK+A+ CK+ +NFNS+  I++GL    VSRL+ TWEK+P+KY +L+ DL DL D S N  + RQLV  E +++ P+IP   +  KDL  IHLGN T   D LINFEKLRM+A E+R L  MC++ Y+L SIL  +K +S    PS+ +F+         S  +S+A +G    +N   + IK+ + ++                             P+K++EE     + + YL +L +
Sbjct:  758 DHVLKVYKADQT-CKYVLIYKETTAHEVVMLTLQEFGIHDPS-SNFSLCEVSVG---DGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELF------------------ELRSRY-----GVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRV-DGLINFEKLRMLAKEVRLLTHMCSSPYDLLSIL-ELKGQS----PSNALFSLN-----QMSASQSNAAAGTVIAANAGQATIKRRKKSTA-------------------------APNPKKMFEEAQMVRRVKAYLNSLKI 1146

HSP 2 Score: 207.608 bits (527), Expect = 1.490e-53
Identity = 126/419 (30.07%), Postives = 219/419 (52.27%), Query Frame = 3

Query:  678 SMSDTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPL---SSDSSNT---------------GKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQD--KDSKTKVMIRKILILWANNHFIDLDDPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTP--FRLIG-----------LQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL 1835
            ++ D   D + K+P  R+E D+E +L+  Q L AF N T   +  +C VM   +V  +   +M DG+ +D+W+V++NG VE+   NGS +E   GDSFG+ P M++  H G M T    C F C+ Q  +  I  +  ++     +E+G + +V E R +    +DS+ +               G VV++GT ++L+  L+ +    DP Y+E+FLLT+R+F+++P+ +  KLL  +  E  D  K  + +  + ++++LW NNHF D  + + +M E+LE FE +    +  + Q + +   AC++ ++ R  TL      SR+ P  FR++G                G++I  +   ++ +  GL+RGDQI  +   S + + T  +A ++L   T+ SI   V+ N   F EI+
Sbjct:   95 TVRDAVRDCLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVVMSDGEELDSWSVLINGAVEIEHANGSREELQMGDSFGILPTMDKLYHRGVMRTKCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQQLVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDF-EADYEMMEFLEVFEALLERKKL-LSQLR-LLHIACAAKARMRSCTL---TRSSRDEPLNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHV-TSKRALEILTGTTHLSIS--VKSNLLGFKEIM 504

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Fly
Match: PDZ-GEF (gene:FBgn0265778 transcript:FBtr0079249)

HSP 1 Score: 261.536 bits (667), Expect = 4.210e-70
Identity = 165/453 (36.42%), Postives = 245/453 (54.08%), Query Frame = 3

Query: 2367 NQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPE-ISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPNFNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFAXXXXXXXXXXXXXSLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSV 3722
            + VLKVY+ +    KYVLI   TTA EVV L ++EF I     +N+SL  V+V    +G ++K  R+    ++LA ++S   RYYLK N +   L+ DE A  L+ ES V    +   E+A +LTL D+A FR I S EY++ +F                  + +S       G      F +L+NRE FW  +EIC E NI +R +++K+FIK+A+ CK+ +NFNS+  I++GL    VSRL+ TWEK+P+KY +L+ DL DL D S N  + RQLV  E +++ P+IP   +  KDL  IHLGN T   D LINFEKLRM+A E+R L  MC++ Y+L SIL  +K +S    PS+ +F+         S  +S+A +G    +N   + IK+ + ++                             P+K++EE     + + YL +L +
Sbjct:  758 DHVLKVYKADQT-CKYVLIYKETTAHEVVMLTLQEFGIHDPS-SNFSLCEVSVG---DGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELF------------------ELRSRY-----GVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRV-DGLINFEKLRMLAKEVRLLTHMCSSPYDLLSIL-ELKGQS----PSNALFSLN-----QMSASQSNAAAGTVIAANAGQATIKRRKKSTA-------------------------APNPKKMFEEAQMVRRVKAYLNSLKI 1146

HSP 2 Score: 207.608 bits (527), Expect = 1.912e-53
Identity = 126/419 (30.07%), Postives = 219/419 (52.27%), Query Frame = 3

Query:  678 SMSDTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPL---SSDSSNT---------------GKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQD--KDSKTKVMIRKILILWANNHFIDLDDPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTP--FRLIG-----------LQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL 1835
            ++ D   D + K+P  R+E D+E +L+  Q L AF N T   +  +C VM   +V  +   +M DG+ +D+W+V++NG VE+   NGS +E   GDSFG+ P M++  H G M T    C F C+ Q  +  I  +  ++     +E+G + +V E R +    +DS+ +               G VV++GT ++L+  L+ +    DP Y+E+FLLT+R+F+++P+ +  KLL  +  E  D  K  + +  + ++++LW NNHF D  + + +M E+LE FE +    +  + Q + +   AC++ ++ R  TL      SR+ P  FR++G                G++I  +   ++ +  GL+RGDQI  +   S + + T  +A ++L   T+ SI   V+ N   F EI+
Sbjct:   95 TVRDAVRDCLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVVMSDGEELDSWSVLINGAVEIEHANGSREELQMGDSFGILPTMDKLYHRGVMRTKCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQQLVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDF-EADYEMMEFLEVFEALLERKKL-LSQLR-LLHIACAAKARMRSCTL---TRSSRDEPLNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHV-TSKRALEILTGTTHLSIS--VKSNLLGFKEIM 504

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Fly
Match: PDZ-GEF (gene:FBgn0265778 transcript:FBtr0333242)

HSP 1 Score: 261.151 bits (666), Expect = 6.049e-70
Identity = 165/453 (36.42%), Postives = 245/453 (54.08%), Query Frame = 3

Query: 2367 NQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPE-ISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPNFNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFAXXXXXXXXXXXXXSLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSV 3722
            + VLKVY+ +    KYVLI   TTA EVV L ++EF I     +N+SL  V+V    +G ++K  R+    ++LA ++S   RYYLK N +   L+ DE A  L+ ES V    +   E+A +LTL D+A FR I S EY++ +F                  + +S       G      F +L+NRE FW  +EIC E NI +R +++K+FIK+A+ CK+ +NFNS+  I++GL    VSRL+ TWEK+P+KY +L+ DL DL D S N  + RQLV  E +++ P+IP   +  KDL  IHLGN T   D LINFEKLRM+A E+R L  MC++ Y+L SIL  +K +S    PS+ +F+         S  +S+A +G    +N   + IK+ + ++                             P+K++EE     + + YL +L +
Sbjct:  758 DHVLKVYKADQT-CKYVLIYKETTAHEVVMLTLQEFGIHDPS-SNFSLCEVSVG---DGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELF------------------ELRSRY-----GVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRV-DGLINFEKLRMLAKEVRLLTHMCSSPYDLLSIL-ELKGQS----PSNALFSLN-----QMSASQSNAAAGTVIAANAGQATIKRRKKSTA-------------------------APNPKKMFEEAQMVRRVKAYLNSLKI 1146

HSP 2 Score: 207.223 bits (526), Expect = 2.318e-53
Identity = 126/419 (30.07%), Postives = 219/419 (52.27%), Query Frame = 3

Query:  678 SMSDTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPL---SSDSSNT---------------GKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQD--KDSKTKVMIRKILILWANNHFIDLDDPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTP--FRLIG-----------LQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL 1835
            ++ D   D + K+P  R+E D+E +L+  Q L AF N T   +  +C VM   +V  +   +M DG+ +D+W+V++NG VE+   NGS +E   GDSFG+ P M++  H G M T    C F C+ Q  +  I  +  ++     +E+G + +V E R +    +DS+ +               G VV++GT ++L+  L+ +    DP Y+E+FLLT+R+F+++P+ +  KLL  +  E  D  K  + +  + ++++LW NNHF D  + + +M E+LE FE +    +  + Q + +   AC++ ++ R  TL      SR+ P  FR++G                G++I  +   ++ +  GL+RGDQI  +   S + + T  +A ++L   T+ SI   V+ N   F EI+
Sbjct:   95 TVRDAVRDCLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVVMSDGEELDSWSVLINGAVEIEHANGSREELQMGDSFGILPTMDKLYHRGVMRTKCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQQLVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDF-EADYEMMEFLEVFEALLERKKL-LSQLR-LLHIACAAKARMRSCTL---TRSSRDEPLNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHV-TSKRALEILTGTTHLSIS--VKSNLLGFKEIM 504

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Fly
Match: PDZ-GEF (gene:FBgn0265778 transcript:FBtr0300038)

HSP 1 Score: 261.151 bits (666), Expect = 6.049e-70
Identity = 165/453 (36.42%), Postives = 245/453 (54.08%), Query Frame = 3

Query: 2367 NQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPE-ISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPNFNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFAXXXXXXXXXXXXXSLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSV 3722
            + VLKVY+ +    KYVLI   TTA EVV L ++EF I     +N+SL  V+V    +G ++K  R+    ++LA ++S   RYYLK N +   L+ DE A  L+ ES V    +   E+A +LTL D+A FR I S EY++ +F                  + +S       G      F +L+NRE FW  +EIC E NI +R +++K+FIK+A+ CK+ +NFNS+  I++GL    VSRL+ TWEK+P+KY +L+ DL DL D S N  + RQLV  E +++ P+IP   +  KDL  IHLGN T   D LINFEKLRM+A E+R L  MC++ Y+L SIL  +K +S    PS+ +F+         S  +S+A +G    +N   + IK+ + ++                             P+K++EE     + + YL +L +
Sbjct:  758 DHVLKVYKADQT-CKYVLIYKETTAHEVVMLTLQEFGIHDPS-SNFSLCEVSVG---DGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELF------------------ELRSRY-----GVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRV-DGLINFEKLRMLAKEVRLLTHMCSSPYDLLSIL-ELKGQS----PSNALFSLN-----QMSASQSNAAAGTVIAANAGQATIKRRKKSTA-------------------------APNPKKMFEEAQMVRRVKAYLNSLKI 1146

HSP 2 Score: 207.223 bits (526), Expect = 2.318e-53
Identity = 126/419 (30.07%), Postives = 219/419 (52.27%), Query Frame = 3

Query:  678 SMSDTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPL---SSDSSNT---------------GKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQD--KDSKTKVMIRKILILWANNHFIDLDDPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTP--FRLIG-----------LQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL 1835
            ++ D   D + K+P  R+E D+E +L+  Q L AF N T   +  +C VM   +V  +   +M DG+ +D+W+V++NG VE+   NGS +E   GDSFG+ P M++  H G M T    C F C+ Q  +  I  +  ++     +E+G + +V E R +    +DS+ +               G VV++GT ++L+  L+ +    DP Y+E+FLLT+R+F+++P+ +  KLL  +  E  D  K  + +  + ++++LW NNHF D  + + +M E+LE FE +    +  + Q + +   AC++ ++ R  TL      SR+ P  FR++G                G++I  +   ++ +  GL+RGDQI  +   S + + T  +A ++L   T+ SI   V+ N   F EI+
Sbjct:   95 TVRDAVRDCLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVVMSDGEELDSWSVLINGAVEIEHANGSREELQMGDSFGILPTMDKLYHRGVMRTKCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQQLVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDF-EADYEMMEFLEVFEALLERKKL-LSQLR-LLHIACAAKARMRSCTL---TRSSRDEPLNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHV-TSKRALEILTGTTHLSIS--VKSNLLGFKEIM 504

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Fly
Match: Epac (gene:FBgn0085421 transcript:FBtr0112636)

HSP 1 Score: 134.035 bits (336), Expect = 2.998e-31
Identity = 103/357 (28.85%), Postives = 164/357 (45.94%), Query Frame = 3

Query: 2382 VYRPNSVDFKYVLIT--NNTTAKEVVPLIIKEFSIDQSEL--ANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSS 3440
            ++R    D  Y  +    +TTA+     +IK  + D+ +L      L  V V SN    + K + V++        LSLN R ++        L   ++ +       + L  +   E+A  +TL ++ LF  +   E + + F                          F     N   F    N   +W  TE+   P+++KR  L++KFIK+A +CK+ +N N+   ++ GL+   VSRL+ TWEK+P+K+ K++++   L D S N R  R  V     +PPLIP + L  KD+   H GNKTS  D L+NFEK+ MMA  +R  +R C             ++RS+ L+P S
Sbjct:  518 IFRVYCADHTYCTLRFPMHTTAE-----LIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSI-----PTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTF----------------------GRHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFV--GKLQPPLIPFMPLLLKDMTFAHEGNKTSL-DGLVNFEKMHMMAQTMRT-IRFC-------------RSRSLGLEPPS 825

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Zebrafish
Match: rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6959])

HSP 1 Score: 243.817 bits (621), Expect = 1.300e-64
Identity = 149/365 (40.82%), Postives = 215/365 (58.90%), Query Frame = 3

Query: 2280 NNRSTSNPDL-KAHEECTNDSLMRENQTTV-NQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMC 3368
             N S+SNPDL ++H       L   NQ  + +QVL+V++ +    +Y++I  +TTAKEVV   I+EF++  +  A YSL  V+V       +IK  R+      LA ++ L+ RYYLK+N+    L +DE A+ LL ES ++L Q+  +E+AT+L++  + LF  I   EYI+ +FK                   K+ L     G  + K FE+ INRE+FW  TE+  E N  KR +++K FIK+A  C++ KNFNS+  II+GL L PVSRL+ TWEK+P+KY KL+ DL DL D S N  + R L+  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM 
Sbjct:  602 GNLSSSNPDLLQSHHRI----LDFNNQPDMSDQVLRVFKADQ-QSRYIMIGKDTTAKEVVAQAIREFALTAAAEA-YSLCEVSVTPE---GVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESHISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFK------------------LKTRL----TGPPSLKLFEEAINRETFWVATEVVREANQLKRMKIVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNLLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMA 934

HSP 2 Score: 223.787 bits (569), Expect = 2.123e-58
Identity = 137/392 (34.95%), Postives = 217/392 (55.36%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDK-----SVFFRACSSNSKPRYITLEVNKNYSRNTPFR---LIGLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL 1835
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV   +   +    G+SFGV P M ++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP YIE+FLLTYR F+ SP V+  +LL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEF       EY++ ++K      +   AC++ +K R +TL      SR  P     L G +KG+ +FI  +   ++    GL+RGDQIL +   ++E +  L KA ++L  NT+ SI   V+ N   F E+L
Sbjct:  117 DIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTHPDSRNEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLPSPMVVGKRLLEWFH-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTHFLEEF-------EYNLEREKMCGHLRLLNIACAAKAKLRVVTL---TKPSREAPLAFTLLGGSEKGFRIFIDSVEPGSKAAEAGLKRGDQILEVNGQNFENV-PLSKANEILKNNTHLSI--TVKTNLLVFKELL 486

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Zebrafish
Match: rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6959])

HSP 1 Score: 243.817 bits (621), Expect = 1.424e-64
Identity = 149/365 (40.82%), Postives = 215/365 (58.90%), Query Frame = 3

Query: 2280 NNRSTSNPDL-KAHEECTNDSLMRENQTTV-NQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMC 3368
             N S+SNPDL ++H       L   NQ  + +QVL+V++ +    +Y++I  +TTAKEVV   I+EF++  +  A YSL  V+V       +IK  R+      LA ++ L+ RYYLK+N+    L +DE A+ LL ES ++L Q+  +E+AT+L++  + LF  I   EYI+ +FK                   K+ L     G  + K FE+ INRE+FW  TE+  E N  KR +++K FIK+A  C++ KNFNS+  II+GL L PVSRL+ TWEK+P+KY KL+ DL DL D S N  + R L+  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM 
Sbjct:  592 GNLSSSNPDLLQSHHRI----LDFNNQPDMSDQVLRVFKADQ-QSRYIMIGKDTTAKEVVAQAIREFALTAAAEA-YSLCEVSVTPE---GVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESHISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFK------------------LKTRL----TGPPSLKLFEEAINRETFWVATEVVREANQLKRMKIVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNLLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMA 924

HSP 2 Score: 223.787 bits (569), Expect = 2.656e-58
Identity = 137/392 (34.95%), Postives = 217/392 (55.36%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDK-----SVFFRACSSNSKPRYITLEVNKNYSRNTPFR---LIGLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL 1835
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV   +   +    G+SFGV P M ++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP YIE+FLLTYR F+ SP V+  +LL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEF       EY++ ++K      +   AC++ +K R +TL      SR  P     L G +KG+ +FI  +   ++    GL+RGDQIL +   ++E +  L KA ++L  NT+ SI   V+ N   F E+L
Sbjct:  107 DIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTHPDSRNEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLPSPMVVGKRLLEWFH-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTHFLEEF-------EYNLEREKMCGHLRLLNIACAAKAKLRVVTL---TKPSREAPLAFTLLGGSEKGFRIFIDSVEPGSKAAEAGLKRGDQILEVNGQNFENV-PLSKANEILKNNTHLSI--TVKTNLLVFKELL 476

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Zebrafish
Match: rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6959])

HSP 1 Score: 243.817 bits (621), Expect = 1.608e-64
Identity = 149/365 (40.82%), Postives = 215/365 (58.90%), Query Frame = 3

Query: 2280 NNRSTSNPDL-KAHEECTNDSLMRENQTTV-NQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMC 3368
             N S+SNPDL ++H       L   NQ  + +QVL+V++ +    +Y++I  +TTAKEVV   I+EF++  +  A YSL  V+V       +IK  R+      LA ++ L+ RYYLK+N+    L +DE A+ LL ES ++L Q+  +E+AT+L++  + LF  I   EYI+ +FK                   K+ L     G  + K FE+ INRE+FW  TE+  E N  KR +++K FIK+A  C++ KNFNS+  II+GL L PVSRL+ TWEK+P+KY KL+ DL DL D S N  + R L+  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM 
Sbjct:  722 GNLSSSNPDLLQSHHRI----LDFNNQPDMSDQVLRVFKADQ-QSRYIMIGKDTTAKEVVAQAIREFALTAAAEA-YSLCEVSVTPE---GVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESHISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFK------------------LKTRL----TGPPSLKLFEEAINRETFWVATEVVREANQLKRMKIVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNLLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMA 1054

HSP 2 Score: 224.172 bits (570), Expect = 2.286e-58
Identity = 137/392 (34.95%), Postives = 217/392 (55.36%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDK-----SVFFRACSSNSKPRYITLEVNKNYSRNTPFR---LIGLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL 1835
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV   +   +    G+SFGV P M ++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP YIE+FLLTYR F+ SP V+  +LL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEF       EY++ ++K      +   AC++ +K R +TL      SR  P     L G +KG+ +FI  +   ++    GL+RGDQIL +   ++E +  L KA ++L  NT+ SI   V+ N   F E+L
Sbjct:  237 DIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTHPDSRNEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLPSPMVVGKRLLEWFH-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTHFLEEF-------EYNLEREKMCGHLRLLNIACAAKAKLRVVTL---TKPSREAPLAFTLLGGSEKGFRIFIDSVEPGSKAAEAGLKRGDQILEVNGQNFENV-PLSKANEILKNNTHLSI--TVKTNLLVFKELL 606

HSP 3 Score: 97.8265 bits (242), Expect = 8.616e-20
Identity = 42/99 (42.42%), Postives = 62/99 (62.63%), Query Frame = 3

Query:   87 DVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDY 383
            D+  + SY   +EAL + +E  +       RYE ++ N  LY   D+ T WYI+LSG V + ++MF PR+SFG RS G++ R  EC++LE +E+IV DY
Sbjct:    1 DLEIVYSYLHGMEALSNLREHQLRIMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDY 99

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Zebrafish
Match: rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6959])

HSP 1 Score: 243.817 bits (621), Expect = 1.903e-64
Identity = 149/365 (40.82%), Postives = 215/365 (58.90%), Query Frame = 3

Query: 2280 NNRSTSNPDL-KAHEECTNDSLMRENQTTV-NQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMC 3368
             N S+SNPDL ++H       L   NQ  + +QVL+V++ +    +Y++I  +TTAKEVV   I+EF++  +  A YSL  V+V       +IK  R+      LA ++ L+ RYYLK+N+    L +DE A+ LL ES ++L Q+  +E+AT+L++  + LF  I   EYI+ +FK                   K+ L     G  + K FE+ INRE+FW  TE+  E N  KR +++K FIK+A  C++ KNFNS+  II+GL L PVSRL+ TWEK+P+KY KL+ DL DL D S N  + R L+  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM 
Sbjct:  763 GNLSSSNPDLLQSHHRI----LDFNNQPDMSDQVLRVFKADQ-QSRYIMIGKDTTAKEVVAQAIREFALTAAAEA-YSLCEVSVTPE---GVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESHISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFK------------------LKTRL----TGPPSLKLFEEAINRETFWVATEVVREANQLKRMKIVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNLLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMA 1095

HSP 2 Score: 223.787 bits (569), Expect = 2.539e-58
Identity = 137/392 (34.95%), Postives = 217/392 (55.36%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDK-----SVFFRACSSNSKPRYITLEVNKNYSRNTPFR---LIGLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL 1835
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV   +   +    G+SFGV P M ++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP YIE+FLLTYR F+ SP V+  +LL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEF       EY++ ++K      +   AC++ +K R +TL      SR  P     L G +KG+ +FI  +   ++    GL+RGDQIL +   ++E +  L KA ++L  NT+ SI   V+ N   F E+L
Sbjct:  278 DIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTHPDSRNEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLPSPMVVGKRLLEWFH-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTHFLEEF-------EYNLEREKMCGHLRLLNIACAAKAKLRVVTL---TKPSREAPLAFTLLGGSEKGFRIFIDSVEPGSKAAEAGLKRGDQILEVNGQNFENV-PLSKANEILKNNTHLSI--TVKTNLLVFKELL 647

HSP 3 Score: 109.383 bits (272), Expect = 2.544e-23
Identity = 49/117 (41.88%), Postives = 73/117 (62.39%), Query Frame = 3

Query:   33 DDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDY 383
            D+ F + + V P+ RT QD+  + SY   +EAL + +E  +       RYE ++ N  LY   D+ T WYI+LSG V + ++MF PR+SFG RS G++ R  EC++LE +E+IV DY
Sbjct:    6 DNSFRQAVMVNPSDRTQQDLEIVYSYLHGMEALSNLREHQLRIMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDY 122

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Zebrafish
Match: rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6959])

HSP 1 Score: 243.817 bits (621), Expect = 2.198e-64
Identity = 149/365 (40.82%), Postives = 215/365 (58.90%), Query Frame = 3

Query: 2280 NNRSTSNPDL-KAHEECTNDSLMRENQTTV-NQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMC 3368
             N S+SNPDL ++H       L   NQ  + +QVL+V++ +    +Y++I  +TTAKEVV   I+EF++  +  A YSL  V+V       +IK  R+      LA ++ L+ RYYLK+N+    L +DE A+ LL ES ++L Q+  +E+AT+L++  + LF  I   EYI+ +FK                   K+ L     G  + K FE+ INRE+FW  TE+  E N  KR +++K FIK+A  C++ KNFNS+  II+GL L PVSRL+ TWEK+P+KY KL+ DL DL D S N  + R L+  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM 
Sbjct:  763 GNLSSSNPDLLQSHHRI----LDFNNQPDMSDQVLRVFKADQ-QSRYIMIGKDTTAKEVVAQAIREFALTAAAEA-YSLCEVSVTPE---GVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESHISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFK------------------LKTRL----TGPPSLKLFEEAINRETFWVATEVVREANQLKRMKIVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNLLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMA 1095

HSP 2 Score: 223.402 bits (568), Expect = 3.606e-58
Identity = 137/392 (34.95%), Postives = 217/392 (55.36%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDK-----SVFFRACSSNSKPRYITLEVNKNYSRNTPFR---LIGLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL 1835
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV   +   +    G+SFGV P M ++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP YIE+FLLTYR F+ SP V+  +LL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEF       EY++ ++K      +   AC++ +K R +TL      SR  P     L G +KG+ +FI  +   ++    GL+RGDQIL +   ++E +  L KA ++L  NT+ SI   V+ N   F E+L
Sbjct:  278 DIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTHPDSRNEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLPSPMVVGKRLLEWFH-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTHFLEEF-------EYNLEREKMCGHLRLLNIACAAKAKLRVVTL---TKPSREAPLAFTLLGGSEKGFRIFIDSVEPGSKAAEAGLKRGDQILEVNGQNFENV-PLSKANEILKNNTHLSI--TVKTNLLVFKELL 647

HSP 3 Score: 109.383 bits (272), Expect = 2.917e-23
Identity = 49/117 (41.88%), Postives = 73/117 (62.39%), Query Frame = 3

Query:   33 DDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDY 383
            D+ F + + V P+ RT QD+  + SY   +EAL + +E  +       RYE ++ N  LY   D+ T WYI+LSG V + ++MF PR+SFG RS G++ R  EC++LE +E+IV DY
Sbjct:    6 DNSFRQAVMVNPSDRTQQDLEIVYSYLHGMEALSNLREHQLRIMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDY 122

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Xenopus
Match: rapgef2 (cathepsin K-like [Source:Xenbase;Acc:XB-GENE-986812])

HSP 1 Score: 252.677 bits (644), Expect = 4.815e-67
Identity = 149/362 (41.16%), Postives = 219/362 (60.50%), Query Frame = 3

Query: 2289 STSNPDL-KAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            S+SNPDL ++H    + +   E     +QVL+V++ +    +Y++I+ +TTAKEVV   I+EF++     A YSL  V+V       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  IE+AT+L++ ++ LFR+I   EYI+ +FKL                           G  N KNFE++IN+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PVSRL+ TWEK+P+KY KL++DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  691 SSSNPDLLQSHHRILDFNTTPEQP---DQVLRVFKADQ-QSRYIMISKDTTAKEVVIQAIREFALTAVPDA-YSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQDLLRESQISLLQLSTIEVATQLSMRNFELFRNIEPTEYIDDLFKLK-----------------------MKTGCTNLKNFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRTTWEKLPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 1020

HSP 2 Score: 236.884 bits (603), Expect = 3.823e-62
Identity = 140/386 (36.27%), Postives = 221/386 (57.25%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYS-IGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI-GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL 1835
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +G  +    G+SFGV P M ++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP YIE+FLLTYR F+ SP  +  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE+   N+E   +G    +   AC++ +K R ITL    +     PF L+ G  KG+G+F+  ++  ++    GL+RGDQIL +   ++E I+ L KA ++L  NT+ S  L V+ N   F E+L
Sbjct:  213 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTVVLNDGEELDSWSVILNGSVEVTYPDGRTEILCMGNSFGVSPTMEKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMEVGKKLLEWFN-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFEN---NLEREKMGGHLRLLNIACAAKAKRRLITL-TKPSREAPLPFNLLGGSDKGFGIFVDSVDPGSKAAETGLKRGDQILEVNGQNFENIQ-LTKALEILRNNTHLS--LTVKTNLFVFKELL 582

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Xenopus
Match: rapgef2 (cathepsin K-like [Source:Xenbase;Acc:XB-GENE-986812])

HSP 1 Score: 252.677 bits (644), Expect = 4.827e-67
Identity = 149/362 (41.16%), Postives = 219/362 (60.50%), Query Frame = 3

Query: 2289 STSNPDL-KAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            S+SNPDL ++H    + +   E     +QVL+V++ +    +Y++I+ +TTAKEVV   I+EF++     A YSL  V+V       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  IE+AT+L++ ++ LFR+I   EYI+ +FKL                           G  N KNFE++IN+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PVSRL+ TWEK+P+KY KL++DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  616 SSSNPDLLQSHHRILDFNTTPEQP---DQVLRVFKADQ-QSRYIMISKDTTAKEVVIQAIREFALTAVPDA-YSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQDLLRESQISLLQLSTIEVATQLSMRNFELFRNIEPTEYIDDLFKLK-----------------------MKTGCTNLKNFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRTTWEKLPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 945

HSP 2 Score: 236.884 bits (603), Expect = 3.825e-62
Identity = 140/386 (36.27%), Postives = 221/386 (57.25%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYS-IGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI-GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL 1835
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +G  +    G+SFGV P M ++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP YIE+FLLTYR F+ SP  +  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE+   N+E   +G    +   AC++ +K R ITL    +     PF L+ G  KG+G+F+  ++  ++    GL+RGDQIL +   ++E I+ L KA ++L  NT+ S  L V+ N   F E+L
Sbjct:  138 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTVVLNDGEELDSWSVILNGSVEVTYPDGRTEILCMGNSFGVSPTMEKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMEVGKKLLEWFN-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFEN---NLEREKMGGHLRLLNIACAAKAKRRLITL-TKPSREAPLPFNLLGGSDKGFGIFVDSVDPGSKAAETGLKRGDQILEVNGQNFENIQ-LTKALEILRNNTHLS--LTVKTNLFVFKELL 507

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Xenopus
Match: rapgef2 (cathepsin K-like [Source:Xenbase;Acc:XB-GENE-986812])

HSP 1 Score: 252.292 bits (643), Expect = 5.184e-67
Identity = 149/362 (41.16%), Postives = 219/362 (60.50%), Query Frame = 3

Query: 2289 STSNPDL-KAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            S+SNPDL ++H    + +   E     +QVL+V++ +    +Y++I+ +TTAKEVV   I+EF++     A YSL  V+V       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  IE+AT+L++ ++ LFR+I   EYI+ +FKL                           G  N KNFE++IN+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PVSRL+ TWEK+P+KY KL++DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  583 SSSNPDLLQSHHRILDFNTTPEQP---DQVLRVFKADQ-QSRYIMISKDTTAKEVVIQAIREFALTAVPDA-YSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQDLLRESQISLLQLSTIEVATQLSMRNFELFRNIEPTEYIDDLFKLK-----------------------MKTGCTNLKNFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRTTWEKLPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 912

HSP 2 Score: 236.498 bits (602), Expect = 4.408e-62
Identity = 140/386 (36.27%), Postives = 221/386 (57.25%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYS-IGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI-GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL 1835
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +G  +    G+SFGV P M ++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP YIE+FLLTYR F+ SP  +  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE+   N+E   +G    +   AC++ +K R ITL    +     PF L+ G  KG+G+F+  ++  ++    GL+RGDQIL +   ++E I+ L KA ++L  NT+ S  L V+ N   F E+L
Sbjct:  105 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTVVLNDGEELDSWSVILNGSVEVTYPDGRTEILCMGNSFGVSPTMEKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMEVGKKLLEWFN-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFEN---NLEREKMGGHLRLLNIACAAKAKRRLITL-TKPSREAPLPFNLLGGSDKGFGIFVDSVDPGSKAAETGLKRGDQILEVNGQNFENIQ-LTKALEILRNNTHLS--LTVKTNLFVFKELL 474

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Xenopus
Match: rapgef2 (cathepsin K-like [Source:Xenbase;Acc:XB-GENE-986812])

HSP 1 Score: 252.292 bits (643), Expect = 7.293e-67
Identity = 149/362 (41.16%), Postives = 219/362 (60.50%), Query Frame = 3

Query: 2289 STSNPDL-KAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            S+SNPDL ++H    + +   E     +QVL+V++ +    +Y++I+ +TTAKEVV   I+EF++     A YSL  V+V       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  IE+AT+L++ ++ LFR+I   EYI+ +FKL                           G  N KNFE++IN+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PVSRL+ TWEK+P+KY KL++DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  738 SSSNPDLLQSHHRILDFNTTPEQP---DQVLRVFKADQ-QSRYIMISKDTTAKEVVIQAIREFALTAVPDA-YSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQDLLRESQISLLQLSTIEVATQLSMRNFELFRNIEPTEYIDDLFKLK-----------------------MKTGCTNLKNFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRTTWEKLPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 1067

HSP 2 Score: 236.498 bits (602), Expect = 4.933e-62
Identity = 140/386 (36.27%), Postives = 221/386 (57.25%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYS-IGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI-GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL 1835
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +G  +    G+SFGV P M ++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP YIE+FLLTYR F+ SP  +  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE+   N+E   +G    +   AC++ +K R ITL    +     PF L+ G  KG+G+F+  ++  ++    GL+RGDQIL +   ++E I+ L KA ++L  NT+ S  L V+ N   F E+L
Sbjct:  260 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTVVLNDGEELDSWSVILNGSVEVTYPDGRTEILCMGNSFGVSPTMEKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMEVGKKLLEWFN-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFEN---NLEREKMGGHLRLLNIACAAKAKRRLITL-TKPSREAPLPFNLLGGSDKGFGIFVDSVDPGSKAAETGLKRGDQILEVNGQNFENIQ-LTKALEILRNNTHLS--LTVKTNLFVFKELL 629

HSP 3 Score: 109.768 bits (273), Expect = 3.114e-23
Identity = 48/117 (41.03%), Postives = 72/117 (61.54%), Query Frame = 3

Query:   33 DDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDY 383
            D+ F + +  PP  R+ QD+  + SY   +EAL + +E  +       RYE ++ N  LY   D+ T WYI+LSG V + ++MF PR+SFG RS G++ R  EC++LE +E+IV DY
Sbjct:    6 DNSFRQAVMKPPADRSAQDLEIVYSYLHGMEALSNLREHQLRLMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDY 122

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Xenopus
Match: rapgef2 (cathepsin K-like [Source:Xenbase;Acc:XB-GENE-986812])

HSP 1 Score: 252.292 bits (643), Expect = 7.544e-67
Identity = 149/362 (41.16%), Postives = 219/362 (60.50%), Query Frame = 3

Query: 2289 STSNPDL-KAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            S+SNPDL ++H    + +   E     +QVL+V++ +    +Y++I+ +TTAKEVV   I+EF++     A YSL  V+V       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  IE+AT+L++ ++ LFR+I   EYI+ +FKL                           G  N KNFE++IN+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PVSRL+ TWEK+P+KY KL++DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  744 SSSNPDLLQSHHRILDFNTTPEQP---DQVLRVFKADQ-QSRYIMISKDTTAKEVVIQAIREFALTAVPDA-YSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQDLLRESQISLLQLSTIEVATQLSMRNFELFRNIEPTEYIDDLFKLK-----------------------MKTGCTNLKNFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRTTWEKLPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 1073

HSP 2 Score: 236.498 bits (602), Expect = 5.694e-62
Identity = 140/386 (36.27%), Postives = 221/386 (57.25%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYS-IGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI-GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL 1835
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +G  +    G+SFGV P M ++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP YIE+FLLTYR F+ SP  +  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE+   N+E   +G    +   AC++ +K R ITL    +     PF L+ G  KG+G+F+  ++  ++    GL+RGDQIL +   ++E I+ L KA ++L  NT+ S  L V+ N   F E+L
Sbjct:  266 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTVVLNDGEELDSWSVILNGSVEVTYPDGRTEILCMGNSFGVSPTMEKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMEVGKKLLEWFN-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFEN---NLEREKMGGHLRLLNIACAAKAKRRLITL-TKPSREAPLPFNLLGGSDKGFGIFVDSVDPGSKAAETGLKRGDQILEVNGQNFENIQ-LTKALEILRNNTHLS--LTVKTNLFVFKELL 635

HSP 3 Score: 109.768 bits (273), Expect = 3.198e-23
Identity = 48/117 (41.03%), Postives = 72/117 (61.54%), Query Frame = 3

Query:   33 DDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDY 383
            D+ F + +  PP  R+ QD+  + SY   +EAL + +E  +       RYE ++ N  LY   D+ T WYI+LSG V + ++MF PR+SFG RS G++ R  EC++LE +E+IV DY
Sbjct:    6 DNSFRQAVMKPPADRSAQDLEIVYSYLHGMEALSNLREHQLRLMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDY 122

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Mouse
Match: Rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:MGI Symbol;Acc:MGI:2659071])

HSP 1 Score: 248.825 bits (634), Expect = 4.617e-66
Identity = 145/362 (40.06%), Postives = 217/362 (59.94%), Query Frame = 3

Query: 2289 STSNPDL-KAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            S+SNPDL ++H    + S   +     +QVL+V++ +    +Y++I+ +TTAKEVV   I+EF++  +    YSL  V+V       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  +E+AT+L++ ++ LFR+I   EYI+ +FKL                              N K FE++IN+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PV+RL+ TWEK+PNKY KL++DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  583 SSSNPDLLQSHHRILDFSTTPD---LPDQVLRVFKADQ-QSRYIMISKDTTAKEVVIQAIREFAVTATP-EQYSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKTSCA-----------------------NLKKFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 912

HSP 2 Score: 239.195 bits (609), Expect = 4.231e-63
Identity = 140/393 (35.62%), Postives = 224/393 (57.00%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYS-IGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI---GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEILDYFSD 1850
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +G  +    G+SFGV P M+++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP +IE+FLLTYR F+ SP  +  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE+   N+E   +G    +   AC++ +K R +TL      SR  P   I   G +KG+G+F+  ++  ++    GL+RGDQIL +   ++E I+ L KA ++L  NT+ SI   V+ N   F E+L   S+
Sbjct:  105 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFN-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFEN---NLEREKMGGHLRLLNIACAAKAKRRLMTL---TKPSREAPLPFILLGGSEKGFGIFVDSVDSCSKATEAGLKRGDQILEVNGQNFENIQ-LSKAMEILRNNTHLSI--TVKTNLFVFKELLTRLSE 479

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Mouse
Match: Rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:MGI Symbol;Acc:MGI:2659071])

HSP 1 Score: 248.054 bits (632), Expect = 7.317e-66
Identity = 145/362 (40.06%), Postives = 217/362 (59.94%), Query Frame = 3

Query: 2289 STSNPDL-KAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            S+SNPDL ++H    + S   +     +QVL+V++ +    +Y++I+ +TTAKEVV   I+EF++  +    YSL  V+V       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  +E+AT+L++ ++ LFR+I   EYI+ +FKL                              N K FE++IN+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PV+RL+ TWEK+PNKY KL++DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  581 SSSNPDLLQSHHRILDFSTTPD---LPDQVLRVFKADQ-QSRYIMISKDTTAKEVVIQAIREFAVTATP-EQYSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKTSCA-----------------------NLKKFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 910

HSP 2 Score: 238.81 bits (608), Expect = 6.420e-63
Identity = 140/393 (35.62%), Postives = 224/393 (57.00%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYS-IGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI---GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEILDYFSD 1850
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +G  +    G+SFGV P M+++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP +IE+FLLTYR F+ SP  +  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE+   N+E   +G    +   AC++ +K R +TL      SR  P   I   G +KG+G+F+  ++  ++    GL+RGDQIL +   ++E I+ L KA ++L  NT+ SI   V+ N   F E+L   S+
Sbjct:  103 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFN-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFEN---NLEREKMGGHLRLLNIACAAKAKRRLMTL---TKPSREAPLPFILLGGSEKGFGIFVDSVDSCSKATEAGLKRGDQILEVNGQNFENIQ-LSKAMEILRNNTHLSI--TVKTNLFVFKELLTRLSE 477

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Mouse
Match: Rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:MGI Symbol;Acc:MGI:2659071])

HSP 1 Score: 248.054 bits (632), Expect = 1.087e-65
Identity = 145/362 (40.06%), Postives = 217/362 (59.94%), Query Frame = 3

Query: 2289 STSNPDL-KAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            S+SNPDL ++H    + S   +     +QVL+V++ +    +Y++I+ +TTAKEVV   I+EF++  +    YSL  V+V       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  +E+AT+L++ ++ LFR+I   EYI+ +FKL                              N K FE++IN+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PV+RL+ TWEK+PNKY KL++DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  731 SSSNPDLLQSHHRILDFSTTPD---LPDQVLRVFKADQ-QSRYIMISKDTTAKEVVIQAIREFAVTATP-EQYSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKTSCA-----------------------NLKKFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 1060

HSP 2 Score: 238.424 bits (607), Expect = 1.027e-62
Identity = 140/393 (35.62%), Postives = 224/393 (57.00%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYS-IGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI---GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEILDYFSD 1850
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +G  +    G+SFGV P M+++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP +IE+FLLTYR F+ SP  +  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE+   N+E   +G    +   AC++ +K R +TL      SR  P   I   G +KG+G+F+  ++  ++    GL+RGDQIL +   ++E I+ L KA ++L  NT+ SI   V+ N   F E+L   S+
Sbjct:  253 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFN-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFEN---NLEREKMGGHLRLLNIACAAKAKRRLMTL---TKPSREAPLPFILLGGSEKGFGIFVDSVDSCSKATEAGLKRGDQILEVNGQNFENIQ-LSKAMEILRNNTHLSI--TVKTNLFVFKELLTRLSE 627

HSP 3 Score: 103.605 bits (257), Expect = 1.676e-21
Identity = 46/106 (43.40%), Postives = 65/106 (61.32%), Query Frame = 3

Query:   66 PNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDY 383
            P  RT QD+  + SY   +EAL + +E  +       RYE ++ N  LY   D+ T WYI+LSG V + ++MF PR+SFG RS G+  R  EC++LE +E+IV DY
Sbjct:    4 PAERTPQDLEIVYSYLHGMEALSNLREHQLRLMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSFRRGCECIVLEPSEMIVVDY 109

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Mouse
Match: Rapgef6 (Rap guanine nucleotide exchange factor (GEF) 6 [Source:MGI Symbol;Acc:MGI:2384761])

HSP 1 Score: 245.743 bits (626), Expect = 1.118e-65
Identity = 147/377 (38.99%), Postives = 223/377 (59.15%), Query Frame = 3

Query: 2289 STSNPDLKAHEECTNDSLMRENQTTV-NQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNR 3416
            S+S+PDL    + T   L   N + + +QV++V++ +     Y++I+ +TTAKEVV   ++EF +  +    YSL  V+V       +IK  R+   F  LA ++ LN RYYLKNN+    L +DE A+ LL ES++++ Q+  IE+AT+L++ D+ LFR+I   EYI+ +FKL                D K+       G  + K FED++N+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PV+RL+ TWEK+P+KY K  +DL DL D S N  + R ++  +  +PP+IP   +  KD+  +H GN +   D L+NFEKLRM+A EIR ++RM +   +   +    K R
Sbjct:  441 SSSSPDLL---QPTTSMLDFSNPSDIPDQVIRVFKADQQSC-YIIISKDTTAKEVVCQAVQEFGLTGAS-DTYSLCEVSVTPE---GVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELLKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKL----------------DSKT-------GNTHLKQFEDIVNQETFWVASEILSESNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRGTWEKLPSKYEKHLQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHIIRMTSANMDPAMMFRQRKKR 785

HSP 2 Score: 204.912 bits (520), Expect = 8.807e-53
Identity = 121/360 (33.61%), Postives = 205/360 (56.94%), Query Frame = 3

Query:  804 KYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEP-QDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIE-YSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI---GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEILDYFSDAESGI 1865
            + E+C VM   +V  +   ++EDGQ +D+W V+LNGTVE+   +G I+    G+SFG+ P +++Q   G + T    C F C+ Q  +  I++ +++    + EE G+I +V+E R L    +  G +V+K T ++LI  L+ +    DP YIE+FLLTYR F+++P  +  KLL+ ++ +  +DK       + +I++LW NNHF D + DP   M ++LEEFE    N+E   +     +   AC++ +K R + L+     SR +P       G +KG+G+F++E+   ++    GL+RGDQ++ +   ++E I TL KA ++L  NT+  + L V+ N   F E+L      +SG+
Sbjct:    4 RRELCSVMVFEVVEQAGAVILEDGQELDSWYVILNGTVEISHPDGKIENLFMGNSFGIVPTLDKQHMHGAVRTKVDDCQFVCIAQQDYWRILN-HVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLETPLDVGIKLLEWFKIDNLRDK-------VTRIVLLWVNNHFNDFEGDPA--MTQFLEEFE---RNLEDTKMNGHLRLLNIACAAKAKWRQVVLQ---KASRESPLHFCLTGGSEKGFGVFVEEVESGSKAADAGLKRGDQVMEVNGQNFENI-TLAKALEILRNNTH--LALTVKTNIFVFKELLSRTEQEKSGV 344

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Mouse
Match: Rapgef6 (Rap guanine nucleotide exchange factor (GEF) 6 [Source:MGI Symbol;Acc:MGI:2384761])

HSP 1 Score: 245.358 bits (625), Expect = 1.297e-65
Identity = 145/360 (40.28%), Postives = 218/360 (60.56%), Query Frame = 3

Query: 2289 STSNPDLKAHEECTNDSLMRENQTTV-NQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRM 3365
            S+S+PDL    + T   L   N + + +QV++V++ +     Y++I+ +TTAKEVV   ++EF +  +    YSL  V+V       +IK  R+   F  LA ++ LN RYYLKNN+    L +DE A+ LL ES++++ Q+  IE+AT+L++ D+ LFR+I   EYI+ +FKL                D K+       G  + K FED++N+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PV+RL+ TWEK+P+KY K  +DL DL D S N  + R ++  +  +PP+IP   +  KD+  +H GN +   D L+NFEKLRM+A EIR ++RM
Sbjct:  441 SSSSPDLL---QPTTSMLDFSNPSDIPDQVIRVFKADQQSC-YIIISKDTTAKEVVCQAVQEFGLTGAS-DTYSLCEVSVTPE---GVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELLKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKL----------------DSKT-------GNTHLKQFEDIVNQETFWVASEILSESNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRGTWEKLPSKYEKHLQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHIIRM 768

HSP 2 Score: 204.912 bits (520), Expect = 8.554e-53
Identity = 121/360 (33.61%), Postives = 205/360 (56.94%), Query Frame = 3

Query:  804 KYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEP-QDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIE-YSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI---GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEILDYFSDAESGI 1865
            + E+C VM   +V  +   ++EDGQ +D+W V+LNGTVE+   +G I+    G+SFG+ P +++Q   G + T    C F C+ Q  +  I++ +++    + EE G+I +V+E R L    +  G +V+K T ++LI  L+ +    DP YIE+FLLTYR F+++P  +  KLL+ ++ +  +DK       + +I++LW NNHF D + DP   M ++LEEFE    N+E   +     +   AC++ +K R + L+     SR +P       G +KG+G+F++E+   ++    GL+RGDQ++ +   ++E I TL KA ++L  NT+  + L V+ N   F E+L      +SG+
Sbjct:    4 RRELCSVMVFEVVEQAGAVILEDGQELDSWYVILNGTVEISHPDGKIENLFMGNSFGIVPTLDKQHMHGAVRTKVDDCQFVCIAQQDYWRILN-HVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLETPLDVGIKLLEWFKIDNLRDK-------VTRIVLLWVNNHFNDFEGDPA--MTQFLEEFE---RNLEDTKMNGHLRLLNIACAAKAKWRQVVLQ---KASRESPLHFCLTGGSEKGFGVFVEEVESGSKAADAGLKRGDQVMEVNGQNFENI-TLAKALEILRNNTH--LALTVKTNIFVFKELLSRTEQEKSGV 344

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. UniProt/SwissProt
Match: sp|Q8CHG7|RPGF2_MOUSE (Rap guanine nucleotide exchange factor 2 OS=Mus musculus OX=10090 GN=Rapgef2 PE=1 SV=2)

HSP 1 Score: 248.825 bits (634), Expect = 3.230e-65
Identity = 145/362 (40.06%), Postives = 217/362 (59.94%), Query Frame = 3

Query: 2289 STSNPDL-KAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            S+SNPDL ++H    + S   +     +QVL+V++ +    +Y++I+ +TTAKEVV   I+EF++  +    YSL  V+V       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  +E+AT+L++ ++ LFR+I   EYI+ +FKL                              N K FE++IN+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PV+RL+ TWEK+PNKY KL++DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  583 SSSNPDLLQSHHRILDFSTTPD---LPDQVLRVFKADQ-QSRYIMISKDTTAKEVVIQAIREFAVTATP-EQYSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKTSCA-----------------------NLKKFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 912

HSP 2 Score: 239.195 bits (609), Expect = 2.960e-62
Identity = 140/393 (35.62%), Postives = 224/393 (57.00%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYS-IGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI---GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEILDYFSD 1850
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +G  +    G+SFGV P M+++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP +IE+FLLTYR F+ SP  +  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE+   N+E   +G    +   AC++ +K R +TL      SR  P   I   G +KG+G+F+  ++  ++    GL+RGDQIL +   ++E I+ L KA ++L  NT+ SI   V+ N   F E+L   S+
Sbjct:  105 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFN-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFEN---NLEREKMGGHLRLLNIACAAKAKRRLMTL---TKPSREAPLPFILLGGSEKGFGIFVDSVDSCSKATEAGLKRGDQILEVNGQNFENIQ-LSKAMEILRNNTHLSI--TVKTNLFVFKELLTRLSE 479

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. UniProt/SwissProt
Match: sp|F1M386|RPGF2_RAT (Rap guanine nucleotide exchange factor 2 OS=Rattus norvegicus OX=10116 GN=Rapgef2 PE=1 SV=2)

HSP 1 Score: 248.44 bits (633), Expect = 4.074e-65
Identity = 145/362 (40.06%), Postives = 217/362 (59.94%), Query Frame = 3

Query: 2289 STSNPDL-KAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            S+SNPDL ++H    + S   +     +QVL+V++ +    +Y++I+ +TTAKEVV   I+EF++  +    YSL  V+V       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  +E+AT+L++ ++ LFR+I   EYI+ +FKL                              N K FE++IN+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PV+RL+ TWEK+PNKY KL++DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  583 SSSNPDLLQSHHRILDFSTTPD---LPDQVLRVFKADQ-QSRYIMISKDTTAKEVVIQAIREFAVTATP-EQYSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKTSCA-----------------------NLKKFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 912

HSP 2 Score: 238.039 bits (606), Expect = 6.802e-62
Identity = 140/393 (35.62%), Postives = 224/393 (57.00%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYS-IGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI---GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEILDYFSD 1850
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +G  +    G+SFGV P M+++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP +IE+FLLTYR F+ SP  +  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE+   N+E   +G    +   AC++ +K R +TL      SR  P   I   G +KG+G+F+  ++  ++    GL+RGDQIL +   ++E I+ L KA ++L  NT+ SI   V+ N   F E+L   S+
Sbjct:  105 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFN-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFEN---NLEREKMGGHLRLLNIACAAKAKRRSMTL---TKPSREAPLPFILLGGSEKGFGIFVDSVDSSSKATEAGLKRGDQILEVNGQNFENIQ-LSKAMEILRNNTHLSI--TVKTNLFVFKELLTRLSE 479

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. UniProt/SwissProt
Match: sp|Q9Y4G8|RPGF2_HUMAN (Rap guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=RAPGEF2 PE=1 SV=1)

HSP 1 Score: 248.44 bits (633), Expect = 4.583e-65
Identity = 145/362 (40.06%), Postives = 217/362 (59.94%), Query Frame = 3

Query: 2289 STSNPDL-KAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            S+SNPDL ++H    + S   +     +QVL+V++ +    +Y++I+ +TTAKEVV   I+EF++  +    YSL  V+V       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  +E+AT+L++ ++ LFR+I   EYI+ +FKL                              N K FE++IN+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PV+RL+ TWEK+PNKY KL++DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  583 SSSNPDLLQSHHRILDFSATPD---LPDQVLRVFKADQ-QSRYIMISKDTTAKEVVIQAIREFAVTATP-DQYSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCA-----------------------NLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 912

HSP 2 Score: 238.424 bits (607), Expect = 4.978e-62
Identity = 140/393 (35.62%), Postives = 224/393 (57.00%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYS-IGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI---GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEILDYFSD 1850
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +G  +    G+SFGV P M+++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP +IE+FLLTYR F+ SP  +  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE+   N+E   +G    +   AC++ +K R +TL      SR  P   I   G +KG+G+F+  ++  ++    GL+RGDQIL +   ++E I+ L KA ++L  NT+ SI   V+ N   F E+L   S+
Sbjct:  105 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFN-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFEN---NLEREKMGGHLRLLNIACAAKAKRRLMTL---TKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQ-LSKAMEILRNNTHLSI--TVKTNLFVFKELLTRLSE 479

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. UniProt/SwissProt
Match: sp|F1PBJ0|RPGF2_CANLF (Rap guanine nucleotide exchange factor 2 OS=Canis lupus familiaris OX=9615 GN=RAPGEF2 PE=1 SV=2)

HSP 1 Score: 248.054 bits (632), Expect = 5.386e-65
Identity = 145/362 (40.06%), Postives = 217/362 (59.94%), Query Frame = 3

Query: 2289 STSNPDL-KAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            S+SNPDL ++H    + S   +     +QVL+V++ +    +Y++I+ +TTAKEVV   I+EF++  +    YSL  V+V       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  +E+AT+L++ ++ LFR+I   EYI+ +FKL                              N K FE++IN+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PV+RL+ TWEK+PNKY KL++DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  583 SSSNPDLLQSHHRILDFSTTPD---LPDQVLRVFKADQ-QSRYIMISKDTTAKEVVIQAIREFAVTATP-DQYSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKTSCA-----------------------NLKKFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 912

HSP 2 Score: 238.424 bits (607), Expect = 5.368e-62
Identity = 140/393 (35.62%), Postives = 224/393 (57.00%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYS-IGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI---GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEILDYFSD 1850
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +G  +    G+SFGV P M+++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP +IE+FLLTYR F+ SP  +  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE+   N+E   +G    +   AC++ +K R +TL      SR  P   I   G +KG+G+F+  ++  ++    GL+RGDQIL +   ++E I+ L KA ++L  NT+ SI   V+ N   F E+L   S+
Sbjct:  105 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFN-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFEN---NLEREKMGGHLRLLNIACAAKAKRRLMTL---TKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQ-LSKAMEILRNNTHLSI--TVKTNLFVFKELLTRLSE 479

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. UniProt/SwissProt
Match: sp|F1MSG6|RPGF2_BOVIN (Rap guanine nucleotide exchange factor 2 OS=Bos taurus OX=9913 GN=RAPGEF2 PE=1 SV=2)

HSP 1 Score: 247.669 bits (631), Expect = 8.366e-65
Identity = 145/362 (40.06%), Postives = 217/362 (59.94%), Query Frame = 3

Query: 2289 STSNPDL-KAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            S+SNPDL ++H    + S   +     +QVL+V++ +    +Y++I+ +TTAKEVV   I+EF++  +    YSL  V+V       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  +E+AT+L++ ++ LFR+I   EYI+ +FKL                              N K FE++IN+E+FW  +EI  E N  KR ++IK FIK+A  C++ KNFNS+  II+GL L PV+RL+ TWEK+PNKY KL++DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  583 SSSNPDLLQSHHRILDFSATPD---LPDQVLRVFKADQ-QSRYIMISKDTTAKEVVVQAIREFAVTATP-DQYSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKS-----------------------KTSCANLKTFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 912

HSP 2 Score: 236.884 bits (603), Expect = 1.618e-61
Identity = 139/393 (35.37%), Postives = 224/393 (57.00%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYS-IGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI---GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEILDYFSD 1850
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +G  +    G+SFGV P M+++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT+++L   L+ +    DP +IE+FLLTYR F+ SP  +  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE+   N+E   +G    +   AC++ +K R +TL      +R  P   I   G +KG+G+F+  ++  ++    GL+RGDQIL +   ++E I+ L KA ++L  NT+ SI   V+ N   F E+L   S+
Sbjct:  105 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLCSPMEVGKKLLEWFN-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFEN---NLEREKMGGHLRLLNIACAAKAKRRLMTL---TKPAREAPLPFILLGGSEKGFGIFVDSVDSASKATEAGLKRGDQILEVNGQNFENIQ-LSKAMEILRNNTHLSI--TVKTNLFVFKELLTRLSE 479

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. TrEMBL
Match: A0A3B1IKT1 (Rap guanine nucleotide exchange factor (GEF) 2 OS=Astyanax mexicanus OX=7994 PE=4 SV=1)

HSP 1 Score: 453.366 bits (1165), Expect = 2.517e-130
Identity = 309/907 (34.07%), Postives = 480/907 (52.92%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFR---LIGLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL-----DYFSDAESGIEFDSPTXXXXXXXXXXXXXXQRYSICKDGAXXXXXXXXXXXXXXXXXXXXXWSNSVTLHGISDHVKNGLNCVITPMAVPRP-NEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDL-KAHEECTNDSLMRENQTT--VNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMC 3368
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV +  G  +    G+SFGV P M ++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT ++L   L+ +    DP YIE+FLLTYR F+ SP V+  KLL+ +       DS  +  + ++++LW NNHF D + DP  +M  +LEEFE+     E   G  + +   AC++ +K R +TL      SR  P     L G +KG+ +FI  +   ++    GL+RGDQIL +   ++E ++ L KA ++L  NT+ SI   V+ N   F E+L     D   D E   E D    A     +  + K+ RYSI          ++      L  +     +N+V   G  + +K   +  +T +  P+P N+  VG                        +S+      ++  KQ+  +  +S     N S+SNPDL ++H    + +   E   T   +QVL+V++ +    +Y++I  +TTAKEVV   I+EF++  +  A YSL  V+V       +IK  R+      LA ++ L+ RYYLK+N+    L +DE A+ LL ES+++L Q+  +E+AT+L++  + LF  I   EYI+ +F                       L   ++G  + K FE+ INRE+FW  TE+  EPN  KR +++K FIK+A  C++ KNFNS+  II+GL L PVSRL+ TWEK+P+KY KL+ DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM 
Sbjct:  105 DIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPEGRTEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTTERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFH------DSSLRDKVTRVVLLWVNNHFNDFEGDP--EMTHFLEEFENNLER-EKMCGHLRLLNI-ACAAKAKLRVVTL---TKPSREAPLAFTLLGGSEKGFRIFIDHVEPGSKAAEAGLKRGDQILEVNGQNFENVQ-LSKANEILRNNTHLSI--TVKTNLLVFKELLARPEHDQEHDHEE--ELDRKNGAPHIPKIGDIKKASRYSI------PDLAVDVEQVMGLEKASKKAKANTV---GGRNKLKKIFDKTLTSILPPKPYNDVGVG------------------------QSQDDSIVGLKQSKQIPPALPVS----GNLSSSNPDLLQSHHRILDFNNQPEPVPTNMSDQVLRVFKADQ-QSRYIMIGKDTTAKEVVAQAIREFALTAAPEA-YSLCEVSVTPE---GVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLF----------------------KLRSRASGPSSLKLFEEAINRETFWVATEVVREPNQLKRMKIVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMA 927

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. TrEMBL
Match: A0A3B4ELQ4 (Rap guanine nucleotide exchange factor (GEF) 2 OS=Pygocentrus nattereri OX=42514 PE=4 SV=1)

HSP 1 Score: 452.981 bits (1164), Expect = 4.564e-129
Identity = 315/906 (34.77%), Postives = 481/906 (53.09%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFR---LIGLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL-----DYFSDAESGIEFDSPTXXXXXXXXXXXXXXQRYSICKDGAXXXXXXXXXXXXXXXXXXXXXWSNSVTLHGISDHVKNGLNCVITPMAVPRP-NEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDL-KAHEECTNDSLMRENQTTV-NQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMC 3368
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV +  G  +    G+SFGV P M ++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT ++L   L+ +    DP YIE+FLLTYR F+ SP V+  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP  +M  +LEEFE+     E   G  + +   AC++ +K R +TL      SR  P     L G +KG+ +FI  +   ++    GL+RGDQIL +   ++E ++ L KA ++L  NT+ SI   V+ N   F E+L     D   D E   E D    A     +  + K+ RYSI  D A +   +    +           +N+V   G  + +K   +  +T +  P+P N+  VG                        +S+      ++  KQ+  +  +S     N S+SNPDL ++H       L   NQ  + +QVL+V++ +    +Y++I  +TTAKEVV   I+EF++  +  A YSL  V+V       +IK  R+      LA ++ L+ RYYLK+N+    L +DE A+ LL ES+++L Q+  +E+AT+L++  + LF  I   EYI+ +F                       L   S G  + K FE+ INRE+FW  TE+  EPN  KR ++IK FIK+A  C++ KNFNS+  II+GL L PVSRL+ TWEK+P+KY KL+ DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM 
Sbjct:  266 DIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPEGRTEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTTERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFH-DPSLRDKVTRV-----VLLWVNNHFNDFEGDP--EMTHFLEEFENNLER-EKMCGHLRLLNI-ACAAKAKLRVVTL---TKPSREAPLAFTLLGGSEKGFRIFIDHVEPGSKAAEAGLKRGDQILEVNGQNFENVQ-LSKANEILRNNTHLSI--TVKTNLLVFKELLARPEHDQEHDHEE--ELDRKNGAPHIPKIGDIKKASRYSI-PDLAVDVEQVMGLEKASKKAK-----ANTV---GGRNKLKKIFDKTLTSILPPKPYNDVGVG------------------------QSQDDSIVGLKQSKQIPPALPVS----GNLSSSNPDLLQSHHRI----LDFNNQPDMSDQVLRVFKADQ-QSRYIMIGKDTTAKEVVAQAIREFALTAAPEA-YSLCEVSVTPE---GVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLF----------------------KLRSRSAGPSSLKLFEEAINRETFWVATEVVREPNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMA 1083

HSP 2 Score: 108.612 bits (270), Expect = 1.213e-19
Identity = 48/117 (41.03%), Postives = 72/117 (61.54%), Query Frame = 3

Query:   33 DDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDY 383
            D+ F + + V P  RT QD+  + SY   +EAL + +E  +       RYE ++ N  LY   D+ + WYI+LSG V + ++MF PR+SFG RS G++ R  EC++LE +E+IV DY
Sbjct:    6 DNSFRQAVMVNPAERTQQDLEIVYSYLHGMEALSNLREHQLRMMCETVRYERHEANEVLYYPDDIGSCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDY 122

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. TrEMBL
Match: A0A3B4ELP0 (Rap guanine nucleotide exchange factor (GEF) 2 OS=Pygocentrus nattereri OX=42514 PE=4 SV=1)

HSP 1 Score: 452.21 bits (1162), Expect = 8.597e-129
Identity = 314/907 (34.62%), Postives = 481/907 (53.03%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFR---LIGLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL-----DYFSDAESGIEFDSPTXXXXXXXXXXXXXXQRYSICKDGAXXXXXXXXXXXXXXXXXXXXXWSNSVTLHGISDHVKNGLNCVITPMAVPRP-NEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDL-KAHEECTNDSLMRENQTT--VNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMC 3368
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV +  G  +    G+SFGV P M ++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT ++L   L+ +    DP YIE+FLLTYR F+ SP V+  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP  +M  +LEEFE+     E   G  + +   AC++ +K R +TL      SR  P     L G +KG+ +FI  +   ++    GL+RGDQIL +   ++E ++ L KA ++L  NT+ SI   V+ N   F E+L     D   D E   E D    A     +  + K+ RYSI  D A +   +    +           +N+V   G  + +K   +  +T +  P+P N+  VG                        +S+      ++  KQ+  +  +S     N S+SNPDL ++H    + +   E   T   +QVL+V++ +    +Y++I  +TTAKEVV   I+EF++  +  A YSL  V+V       +IK  R+      LA ++ L+ RYYLK+N+    L +DE A+ LL ES+++L Q+  +E+AT+L++  + LF  I   EYI+ +F                       L   S G  + K FE+ INRE+FW  TE+  EPN  KR ++IK FIK+A  C++ KNFNS+  II+GL L PVSRL+ TWEK+P+KY KL+ DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM 
Sbjct:  260 DIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPEGRTEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTTERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFH-DPSLRDKVTRV-----VLLWVNNHFNDFEGDP--EMTHFLEEFENNLER-EKMCGHLRLLNI-ACAAKAKLRVVTL---TKPSREAPLAFTLLGGSEKGFRIFIDHVEPGSKAAEAGLKRGDQILEVNGQNFENVQ-LSKANEILRNNTHLSI--TVKTNLLVFKELLARPEHDQEHDHEE--ELDRKNGAPHIPKIGDIKKASRYSI-PDLAVDVEQVMGLEKASKKAK-----ANTV---GGRNKLKKIFDKTLTSILPPKPYNDVGVG------------------------QSQDDSIVGLKQSKQIPPALPVS----GNLSSSNPDLLQSHHRILDFNNQPEAIPTNMSDQVLRVFKADQ-QSRYIMIGKDTTAKEVVAQAIREFALTAAPEA-YSLCEVSVTPE---GVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLF----------------------KLRSRSAGPSSLKLFEEAINRETFWVATEVVREPNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMA 1082

HSP 2 Score: 108.612 bits (270), Expect = 1.265e-19
Identity = 48/117 (41.03%), Postives = 72/117 (61.54%), Query Frame = 3

Query:   33 DDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDY 383
            D+ F + + V P  RT QD+  + SY   +EAL + +E  +       RYE ++ N  LY   D+ + WYI+LSG V + ++MF PR+SFG RS G++ R  EC++LE +E+IV DY
Sbjct:    6 DNSFRQAVMVNPAERTQQDLEIVYSYLHGMEALSNLREHQLRMMCETVRYERHEANEVLYYPDDIGSCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDY 122

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. TrEMBL
Match: A0A3B4DC63 (Rap guanine nucleotide exchange factor (GEF) 2 OS=Pygocentrus nattereri OX=42514 PE=4 SV=1)

HSP 1 Score: 452.21 bits (1162), Expect = 8.903e-129
Identity = 314/907 (34.62%), Postives = 481/907 (53.03%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFR---LIGLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL-----DYFSDAESGIEFDSPTXXXXXXXXXXXXXXQRYSICKDGAXXXXXXXXXXXXXXXXXXXXXWSNSVTLHGISDHVKNGLNCVITPMAVPRP-NEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDL-KAHEECTNDSLMRENQTT--VNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMC 3368
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV +  G  +    G+SFGV P M ++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT ++L   L+ +    DP YIE+FLLTYR F+ SP V+  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP  +M  +LEEFE+     E   G  + +   AC++ +K R +TL      SR  P     L G +KG+ +FI  +   ++    GL+RGDQIL +   ++E ++ L KA ++L  NT+ SI   V+ N   F E+L     D   D E   E D    A     +  + K+ RYSI  D A +   +    +           +N+V   G  + +K   +  +T +  P+P N+  VG                        +S+      ++  KQ+  +  +S     N S+SNPDL ++H    + +   E   T   +QVL+V++ +    +Y++I  +TTAKEVV   I+EF++  +  A YSL  V+V       +IK  R+      LA ++ L+ RYYLK+N+    L +DE A+ LL ES+++L Q+  +E+AT+L++  + LF  I   EYI+ +F                       L   S G  + K FE+ INRE+FW  TE+  EPN  KR ++IK FIK+A  C++ KNFNS+  II+GL L PVSRL+ TWEK+P+KY KL+ DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM 
Sbjct:  266 DIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPEGRTEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTTERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFH-DPSLRDKVTRV-----VLLWVNNHFNDFEGDP--EMTHFLEEFENNLER-EKMCGHLRLLNI-ACAAKAKLRVVTL---TKPSREAPLAFTLLGGSEKGFRIFIDHVEPGSKAAEAGLKRGDQILEVNGQNFENVQ-LSKANEILRNNTHLSI--TVKTNLLVFKELLARPEHDQEHDHEE--ELDRKNGAPHIPKIGDIKKASRYSI-PDLAVDVEQVMGLEKASKKAK-----ANTV---GGRNKLKKIFDKTLTSILPPKPYNDVGVG------------------------QSQDDSIVGLKQSKQIPPALPVS----GNLSSSNPDLLQSHHRILDFNNQPEAIPTNMSDQVLRVFKADQ-QSRYIMIGKDTTAKEVVAQAIREFALTAAPEA-YSLCEVSVTPE---GVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLF----------------------KLRSRSAGPSSLKLFEEAINRETFWVATEVVREPNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMA 1088

HSP 2 Score: 108.612 bits (270), Expect = 1.278e-19
Identity = 48/117 (41.03%), Postives = 72/117 (61.54%), Query Frame = 3

Query:   33 DDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDY 383
            D+ F + + V P  RT QD+  + SY   +EAL + +E  +       RYE ++ N  LY   D+ + WYI+LSG V + ++MF PR+SFG RS G++ R  EC++LE +E+IV DY
Sbjct:    6 DNSFRQAVMVNPAERTQQDLEIVYSYLHGMEALSNLREHQLRMMCETVRYERHEANEVLYYPDDIGSCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDY 122

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. TrEMBL
Match: A0A3B4DC09 (Rap guanine nucleotide exchange factor (GEF) 2 OS=Pygocentrus nattereri OX=42514 PE=4 SV=1)

HSP 1 Score: 451.44 bits (1160), Expect = 1.584e-128
Identity = 314/907 (34.62%), Postives = 481/907 (53.03%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFR---LIGLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL-----DYFSDAESGIEFDSPTXXXXXXXXXXXXXXQRYSICKDGAXXXXXXXXXXXXXXXXXXXXXWSNSVTLHGISDHVKNGLNCVITPMAVPRP-NEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDL-KAHEECTNDSLMRENQTT--VNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMC 3368
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV +  G  +    G+SFGV P M ++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT ++L   L+ +    DP YIE+FLLTYR F+ SP V+  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP  +M  +LEEFE+     E   G  + +   AC++ +K R +TL      SR  P     L G +KG+ +FI  +   ++    GL+RGDQIL +   ++E ++ L KA ++L  NT+ SI   V+ N   F E+L     D   D E   E D    A     +  + K+ RYSI  D A +   +    +           +N+V   G  + +K   +  +T +  P+P N+  VG                        +S+      ++  KQ+  +  +S     N S+SNPDL ++H    + +   E   T   +QVL+V++ +    +Y++I  +TTAKEVV   I+EF++  +  A YSL  V+V       +IK  R+      LA ++ L+ RYYLK+N+    L +DE A+ LL ES+++L Q+  +E+AT+L++  + LF  I   EYI+ +F                       L   S G  + K FE+ INRE+FW  TE+  EPN  KR ++IK FIK+A  C++ KNFNS+  II+GL L PVSRL+ TWEK+P+KY KL+ DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM 
Sbjct:  266 DIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPEGRTEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTTERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFH-DPSLRDKVTRV-----VLLWVNNHFNDFEGDP--EMTHFLEEFENNLER-EKMCGHLRLLNI-ACAAKAKLRVVTL---TKPSREAPLAFTLLGGSEKGFRIFIDHVEPGSKAAEAGLKRGDQILEVNGQNFENVQ-LSKANEILRNNTHLSI--TVKTNLLVFKELLARPEHDQEHDHEE--ELDRKNGAPHIPKIGDIKKASRYSI-PDLAVDVEQVMGLEKASKKAK-----ANTV---GGRNKLKKIFDKTLTSILPPKPYNDVGVG------------------------QSQDDSIVGLKQSKQIPPALPVS----GNLSSSNPDLLQSHHRILDFNNQPEAIPTNMSDQVLRVFKADQ-QSRYIMIGKDTTAKEVVAQAIREFALTAAPEA-YSLCEVSVTPE---GVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLF----------------------KLRSRSAGPSSLKLFEEAINRETFWVATEVVREPNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMA 1088

HSP 2 Score: 108.227 bits (269), Expect = 1.292e-19
Identity = 48/117 (41.03%), Postives = 72/117 (61.54%), Query Frame = 3

Query:   33 DDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDY 383
            D+ F + + V P  RT QD+  + SY   +EAL + +E  +       RYE ++ N  LY   D+ + WYI+LSG V + ++MF PR+SFG RS G++ R  EC++LE +E+IV DY
Sbjct:    6 DNSFRQAVMVNPAERTQQDLEIVYSYLHGMEALSNLREHQLRMMCETVRYERHEANEVLYYPDDIGSCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDY 122

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Cavefish
Match: rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6959])

HSP 1 Score: 453.366 bits (1165), Expect = 9.535e-134
Identity = 309/907 (34.07%), Postives = 480/907 (52.92%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFR---LIGLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL-----DYFSDAESGIEFDSPTXXXXXXXXXXXXXXQRYSICKDGAXXXXXXXXXXXXXXXXXXXXXWSNSVTLHGISDHVKNGLNCVITPMAVPRP-NEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDL-KAHEECTNDSLMRENQTT--VNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMC 3368
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV +  G  +    G+SFGV P M ++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT ++L   L+ +    DP YIE+FLLTYR F+ SP V+  KLL+ +       DS  +  + ++++LW NNHF D + DP  +M  +LEEFE+     E   G  + +   AC++ +K R +TL      SR  P     L G +KG+ +FI  +   ++    GL+RGDQIL +   ++E ++ L KA ++L  NT+ SI   V+ N   F E+L     D   D E   E D    A     +  + K+ RYSI          ++      L  +     +N+V   G  + +K   +  +T +  P+P N+  VG                        +S+      ++  KQ+  +  +S     N S+SNPDL ++H    + +   E   T   +QVL+V++ +    +Y++I  +TTAKEVV   I+EF++  +  A YSL  V+V       +IK  R+      LA ++ L+ RYYLK+N+    L +DE A+ LL ES+++L Q+  +E+AT+L++  + LF  I   EYI+ +F                       L   ++G  + K FE+ INRE+FW  TE+  EPN  KR +++K FIK+A  C++ KNFNS+  II+GL L PVSRL+ TWEK+P+KY KL+ DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM 
Sbjct:  105 DIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPEGRTEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTTERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFH------DSSLRDKVTRVVLLWVNNHFNDFEGDP--EMTHFLEEFENNLER-EKMCGHLRLLNI-ACAAKAKLRVVTL---TKPSREAPLAFTLLGGSEKGFRIFIDHVEPGSKAAEAGLKRGDQILEVNGQNFENVQ-LSKANEILRNNTHLSI--TVKTNLLVFKELLARPEHDQEHDHEE--ELDRKNGAPHIPKIGDIKKASRYSI------PDLAVDVEQVMGLEKASKKAKANTV---GGRNKLKKIFDKTLTSILPPKPYNDVGVG------------------------QSQDDSIVGLKQSKQIPPALPVS----GNLSSSNPDLLQSHHRILDFNNQPEPVPTNMSDQVLRVFKADQ-QSRYIMIGKDTTAKEVVAQAIREFALTAAPEA-YSLCEVSVTPE---GVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLF----------------------KLRSRASGPSSLKLFEEAINRETFWVATEVVREPNQLKRMKIVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMA 927

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BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Cavefish
Match: rapgef6 (Rap guanine nucleotide exchange factor (GEF) 6 [Source:ZFIN;Acc:ZDB-GENE-030131-6972])

HSP 1 Score: 246.899 bits (629), Expect = 7.874e-68
Identity = 131/333 (39.34%), Postives = 204/333 (61.26%), Query Frame = 3

Query: 2367 NQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRM 3365
            +QV++V++ +     Y++I+ +TTAK+VV  ++ EF +  +    YSL  V++       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  +E+A +L++ D+ +FR+I S EY++ +F                    K +  G   G+   K FE+LIN+E+FW  TEI  E N  KR + +K FIK+A  C++ KNFNS+  II+GL L+PV+RL+ TWEK+P+KY KL+ DL D+ D S N  + R ++  +  +PP+IP   +  KDL  +H GN ++  D L+NFEKLRM+A EIR ++RM
Sbjct:   32 DQVIRVFKADQQSC-YIIISKDTTAKDVVSHVVNEFGLIAAP-ETYSLCEVSISPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVAAQLSMRDFGIFRNIESTEYVDDLF--------------------KLDPGGGEGGH--LKQFEELINQETFWVATEILCEANAFKRMKTVKHFIKIALHCRECKNFNSMFAIISGLNLSPVARLRGTWEKLPSKYEKLFRDLQDIFDPSRNMAKYRNILSSQSVQPPIIPLFPVVKKDLTFLHEGNDSNV-DGLVNFEKLRMIAKEIRHVVRM 336

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BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Cavefish
Match: rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6959])

HSP 1 Score: 248.825 bits (634), Expect = 3.097e-66
Identity = 147/365 (40.27%), Postives = 216/365 (59.18%), Query Frame = 3

Query: 2280 NNRSTSNPDL-KAHEECTNDSLMRENQTTV-NQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMC 3368
             N S+SNPDL ++H       L   NQ  + +QVL+V++ +    +Y++I  +TTAKEVV   I+EF++  +  A YSL  V+V       +IK  R+      LA ++ L+ RYYLK+N+    L +DE A+ LL ES+++L Q+  +E+AT+L++  + LF  I   EYI+ +F                       L   ++G  + K FE+ INRE+FW  TE+  EPN  KR +++K FIK+A  C++ KNFNS+  II+GL L PVSRL+ TWEK+P+KY KL+ DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM 
Sbjct:  576 GNLSSSNPDLLQSHHRI----LDFNNQPDMSDQVLRVFKADQ-QSRYIMIGKDTTAKEVVAQAIREFALTAAPEA-YSLCEVSVTPE---GVIKQRRLPEQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLF----------------------KLRSRASGPSSLKLFEEAINRETFWVATEVVREPNQLKRMKIVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMA 908

HSP 2 Score: 230.72 bits (587), Expect = 1.380e-60
Identity = 132/372 (35.48%), Postives = 209/372 (56.18%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFR---LIGLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSI 1790
            D   D + K+P  R + DIE +L+ +  LPAF N T   + E+C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV +  G  +    G+SFGV P M ++   G M T    C F C+ Q  +C I+++ ++  + + EE G+I +V E R L    +  G +V+KGT ++L   L+ +    DP YIE+FLLTYR F+ SP V+  KLL+ +       DS  +  + ++++LW NNHF D + DP  +M  +LEEFE+     E   G  + +   AC++ +K R +TL      SR  P     L G +KG+ +FI  +   ++    GL+RGDQIL +   ++E ++ L KA ++L  NT+ SI
Sbjct:  112 DIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPEGRTEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQ-VEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTTERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFH------DSSLRDKVTRVVLLWVNNHFNDFEGDP--EMTHFLEEFENNLER-EKMCGHLR-LLNIACAAKAKLRVVTL---TKPSREAPLAFTLLGGSEKGFRIFIDHVEPGSKAAEAGLKRGDQILEVNGQNFENVQ-LSKANEILRNNTHLSI 468

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BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Cavefish
Match: si:dkey-253i9.4 (si:dkey-253i9.4 [Source:ZFIN;Acc:ZDB-GENE-090313-280])

HSP 1 Score: 238.81 bits (608), Expect = 1.270e-63
Identity = 137/385 (35.58%), Postives = 218/385 (56.62%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI-GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL 1835
            D   D + K+P  R + DIE +L+ VQ LPAF + +   + E+C VM   +V  +   ++  G+ +D+W+V+LNG VEV + +G  +    G SFGV P+M ++   G M T    C F C+ Q  +C I+++ ++      EE G+I +V E R L    +  G +VVKGT ++LI  L+ D    DP YIE+FLLTYR FV SP ++  +LL  +  +P  +D  T+V     ++LW NNHF D + DP  DM  +LEEF++     +   GQ + +   AC++ +KPR +++    +     PF LI G ++G  LFI  +   ++ +  GL+RGDQIL +   ++E ++ L KAT++L  N + S  + V+ N   F E++
Sbjct:  242 DIVRDCLEKDPMDRTDDDIEQLLEFVQQLPAFASLSVSVRRELCAVMVFAVVERAGTIVLNHGEELDSWSVILNGAVEVMYPDGQCETVGMGGSFGVSPSMEKELMVGVMRTKVDDCQFVCIAQQDYCCILNQ-VEQNTQRVEEEGEIVMVKEHRELDRTGTRKGHIVVKGTTERLIQHLVEDHSVVDPTYIEDFLLTYRTFVSSPLIVGQRLLDWFN-DPGLRDKVTRV-----VLLWVNNHFSDFEGDP--DMTNFLEEFQNYLERDQKMTGQLRLLNI-ACAAKAKPRVVSI-TRGSREMPLPFTLIGGAERGTRLFISSVEMGSKAEEAGLKRGDQILEVNGQTFENVQ-LSKATEILKNNLHLS--MTVKTNLLVFKELV 612

HSP 2 Score: 229.95 bits (585), Expect = 1.035e-60
Identity = 144/365 (39.45%), Postives = 205/365 (56.16%), Query Frame = 3

Query: 2280 NNRSTSNPDLKAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNT 3374
             N S+SNPDL   ++     ++  +    +QVL+V++ +    +Y+LI  +TTA+EV  L IKEF +     A YSL  V+V       +IK  R+      LA ++ L  RYYLK+N+    L +D +A+ L  ES+V L  +   EIA +L+  +Y LF  +   +YI  +FKL P +                          N +NFEDLIN+E+FW  TEI  E N  KR ++IK FIKVA  C+D KNFNS+  II+GL L PVSRL+ TWE++P KY KL  +L ++ D S N  + R L+     +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR ++RM + 
Sbjct:  713 GNLSSSNPDLAQGQQ----RIIDYSTQPPDQVLRVFKADQ-QSRYLLINRDTTAREVANLAIKEFGLGGGPEA-YSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLCARYYLKSNMETETLCSDVEAQELQRESQVCLLSLSCTEIANQLSARNYLLFASVEPTDYITDLFKLRPHERPA-----------------------NLRNFEDLINQETFWVATEIVREANQVKRMKIIKHFIKVALHCRDCKNFNSMFAIISGLNLAPVSRLRATWERLPGKYEKLLSELQEVFDPSRNMAKYRNLLNKHNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAREIRHVVRMASV 1044

HSP 3 Score: 98.9821 bits (245), Expect = 3.218e-20
Identity = 43/104 (41.35%), Postives = 65/104 (62.50%), Query Frame = 3

Query:   84 QDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDYSLET 395
            +D+  + SY   +EAL + +E  +       RYE ++ N  LY   D+ T WYI+LSG V + ++MF PR+SFG RS G++ R  EC++LE +E+IV DY  E+
Sbjct:   20 RDLQIVYSYLHGMEALSNLREHQLRLMCETVRYEQHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEASEMIVVDYVEES 123

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BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Cavefish
Match: ENSAMXT00000037388.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000923.1:822:27188:-1 gene:ENSAMXG00000035968.1 transcript:ENSAMXT00000037388.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 175.637 bits (444), Expect = 1.270e-44
Identity = 106/320 (33.12%), Postives = 178/320 (55.62%), Query Frame = 3

Query:  882 MDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLDDPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI---GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEI 1832
            +D W V+LNG VE+   +G  +    G+SFG+  ++++Q   GE+ +    C F C+ Q  +  I++ +++    + EE G+I +V E R L    +  G +V+KGT D+LI  L+ +    DP YIE+FLLTYR F+  P  +  KLL+ ++ +   +D+ T     +I++LW NNHF D +  N  M ++LE FE +   ++  +     +   AC++ +K R +TL+     SR +P       G +KG+G+FI+ +   ++    GL+RGDQI+ +   ++E I +  KA D+L  NT+ S  L V+ N   F E+
Sbjct:   54 LDQWYVILNGAVEIGHGDGRTEILCMGNSFGISASLDKQYVNGEVRSKGDDCQFVCIAQEDYWRILN-HVEKNTHKVEEEGEIVMVKEHRELDRSGTRKGHIVIKGTPDRLIMHLVEEPSVVDPTYIEDFLLTYRTFLSCPMEVGKKLLEWFKVDSL-RDTVT-----RIVLLWVNNHFNDFEG-NPSMTQFLENFEKL---LDEKMKGHLRLLNIACAAKAKWRQVTLQ---KPSRESPLHFSLQGGSEKGFGIFIEAVEVGSKAAEAGLKRGDQIMEINGQNFENI-SYTKAVDILKNNTHLS--LTVKTNIFVFKEL 356

HSP 2 Score: 145.206 bits (365), Expect = 6.342e-35
Identity = 85/244 (34.84%), Postives = 136/244 (55.74%), Query Frame = 3

Query: 2367 NQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRL 3098
            +QV++V++ +     Y++I+ +TTAK+VV  ++ EF +  +    YSL  V++       +IK  R+      LA ++ L+ RYYLKNN+    L +DE A+ LL ES+++L Q+  +E+A +L++ D+ +FR+I S EY++ +F                    K +  G   G+   K FE+LIN+E+FW  TEI  E N  KR + +K FIK+A  C++ KNFNS+  II        S L
Sbjct:  489 DQVIRVFKADQQSC-YIIISKDTTAKDVVSHVVNEFGLIAAP-ETYSLCEVSISPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVAAQLSMRDFGIFRNIESTEYVDDLF--------------------KLDPGGGEGGH--LKQFEELINQETFWVATEILCEANAFKRMKTVKHFIKIALHCRECKNFNSMFAIIRFFLFLATSNL 705

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BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Sea Lamprey
Match: rapgef2 (Rap guanine nucleotide exchange factor (GEF) 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6959])

HSP 1 Score: 225.713 bits (574), Expect = 4.413e-61
Identity = 131/363 (36.09%), Postives = 210/363 (57.85%), Query Frame = 3

Query: 2289 STSNPDLKAHEECTNDSLMRENQTTV-NQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNT 3374
            S+SNPDL    +C   + +      + +QV+KVYR +    +YV+++  ++A+EVV   ++EF + ++  A YSL  V+V        IK  R+  +   LA  + LN RYYLKNN     L +DE A+ LL ES+++L Q+  +E+AT++++ D+ +FR I   EY+  +F+L                       G +   E+ + FE+ +NRE+FW  +E+  E  + KR +LIK ++K+A  C+D +NFNS+  II+GL+ + V RL+  W+K+P+KY KL+ DL DL D S N  + R L+     +PP+IP   +  KDL  +H GN +  +  L+NFEKLRM+A E+R + R+ + 
Sbjct:  534 SSSNPDLV---QCHGTAELGTAPGDIPDQVVKVYRADQSS-RYVMVSRESSAREVVLAALREFQVCEAAEA-YSLCEVSVSPE---GFIKQRRLPDHLNKLAESIQLNARYYLKNNSQTEPLCSDEHAQELLKESQISLLQLSTLEVATQISIRDFQIFRSIEPTEYVANLFRL-----------------------GGAAACEHLQAFEETLNRETFWVPSEVLRETGLLKRVKLIKHYLKIALNCRDSRNFNSMFAIISGLSHSSVMRLRSAWDKLPSKYEKLFSDLQDLFDPSRNMAKYRNLLSSPSLQPPIIPLFPVVKKDLTFLHDGNDSRVEG-LVNFEKLRMIAKEVRHVGRLASA 864

HSP 2 Score: 190.274 bits (482), Expect = 1.627e-49
Identity = 116/363 (31.96%), Postives = 199/363 (54.82%), Query Frame = 3

Query:  804 KYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEI---VSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTP--FRLIGLQ-KGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEILDYFSDAE-SGIE 1868
            + E+C  M   +V  +   ++ DG+ +D+W V+LNG+VE+   +G  +    G+ FGV P+M ++  TG M T    C F C+ Q  +C I   V RN+  +    EE G+I +V E R L    +  G +V+KGT ++LI+ L+ +    DP Y+E+FLLTYR F      I  +LLQ +       DS  +  + ++++LW NNHF D + DP  D+ ++LE FE      E   G  + +   AC++ ++ R++T+   +  SR +P  F+L G Q +G+ L++  ++  ++    GL+RGDQIL +   +++ +  L +A D++  +T+ SI   V+ N   + EI     + + SG++
Sbjct:  105 RRELCASMVFAVVEKAGTVVLRDGEELDSWCVILNGSVEISRADGRTETLCMGNCFGVSPSMEKELMTGVMKTKVDDCQFVCIAQKDYCRILNKVERNMQKV----EEEGEIVMVKEHRELDRTGTRKGHIVIKGTPERLINHLVEEHSVVDPTYVEDFLLTYRTFQPHGLDIGKRLLQWFN------DSSLRDKVTRVVLLWVNNHFNDFESDP--DLMQFLENFESCLER-EKMHGHLRLLNI-ACAAKARVRHVTV---RRASRESPLGFKLDGGQDRGFPLYVSSLDLQSKASESGLKRGDQILEVNGQNFDNV-LLSQAMDIMKKSTHLSI--TVKNNLLSYKEICHRLEEEQTSGVQ 447

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005082.1 (pep scaffold:Pmarinus_7.0:GL478314:141397:156611:1 gene:ENSPMAG00000004611.1 transcript:ENSPMAT00000005082.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 164.466 bits (415), Expect = 2.803e-42
Identity = 84/233 (36.05%), Postives = 132/233 (56.65%), Query Frame = 3

Query: 2718 IEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNR 3416
            +E+A ++++ D+ LFR I   EY++ +FKL                           G    K FE  +N+E+FW  +E+  EP   KR +++K FIK+A  C++ KNFNS+  II+GL+ + V+RL  TWEK+P KY  LY +L DL D S N  + R ++  +  +PPLIP   +  KDL  +H GN +   D ++NFEKLRM+A E+R+++RM +   +  ++    + R
Sbjct:    1 VEVAAQVSMGDFDLFRTIEPTEYVDDLFKLRSR-----------------------TGTRALKLFEGALNQETFWVASEVLAEPGQIKRVKVLKHFIKIALHCRECKNFNSMFAIISGLSHSSVARLNGTWEKLPTKYESLYRELQDLFDPSRNMAKYRNVLSSQSLQPPLIPLFPVVKKDLTFLHEGNDSRV-DGMVNFEKLRMIAKEVRQVVRMASVGMDAAAMFRHRRKR 209

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BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005209.1 (pep scaffold:Pmarinus_7.0:GL478155:18709:35318:-1 gene:ENSPMAG00000004729.1 transcript:ENSPMAT00000005209.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 56.225 bits (134), Expect = 5.789e-8
Identity = 43/153 (28.10%), Postives = 75/153 (49.02%), Query Frame = 3

Query: 2934 SFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVL-PEISEP-PLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNL 3386
            S W + EI    +I  +  ++ KF+ VAK C  L+NF S M I+ GL    V +L + W  +P+K + + E   +L  + +  +   + +L  + S P P IPC  L S  +  + +G  T   + +  + KLR +A  + ++    +  Y L
Sbjct:  435 STWVSAEILSCDSIKTQLAVLSKFLHVAKTCSSLRNFASSMQILNGLENFTVRQLPV-WRSLPSKAMAIME---ELVAVKVFLKSDSECLLEADTSRPKPTIPCPHLFSMHVQQLEVGGFT-MANRMYKWPKLRSLARTVHQIAAFQSRTYAL 582

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BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Sea Lamprey
Match: rgl1 (ral guanine nucleotide dissociation stimulator-like 1 [Source:NCBI gene;Acc:402933])

HSP 1 Score: 49.6766 bits (117), Expect = 6.919e-6
Identity = 26/74 (35.14%), Postives = 44/74 (59.46%), Query Frame = 3

Query: 2991 LIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPE 3212
            +++ +I VA+ C+ LKNF+SL  I++ L   P+ RLK TW  V  + I  + +LS++     N    R+L++ E
Sbjct:  427 VVEHWIAVAQECRMLKNFSSLRAILSALQTNPIHRLKKTWCCVSREKIVAFAELSEIFSDENNHFTSRELLMKE 500

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BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Sea Lamprey
Match: sos2 (son of sevenless homolog 2 (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-090319-5])

HSP 1 Score: 49.2914 bits (116), Expect = 9.026e-6
Identity = 34/138 (24.64%), Postives = 62/138 (44.93%), Query Frame = 3

Query: 2709 MEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVP 3122
            + PIEIA +LTLI+  L+R +  +E +  V+               + ED + N         +  N        + W    +    N  +R  ++ + I+VA+  ++L NFN ++ +++ ++  PV RL  T E  P
Sbjct:  757 LHPIEIARQLTLIESELYRAVQPSELVGSVW---------------TKEDKEINSPNLLRMIRHTTNL-------TLWFEKCLVEAENFEERVAVMTRIIEVAQVFQELNNFNGVLEVVSAMSSAPVYRLHHTLEVTP 872

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Yeast
Match: CDC25 (Membrane bound guanine nucleotide exchange factor; also known as a GEF or GDP-release factor; indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1; thermosensitivity of the cdc25-5 mutant is functionally complemented by human RASGRF1 or by a fragment of human SOS1 comprising the CDC25-related catalytic domain [Source:SGD;Acc:S000004301])

HSP 1 Score: 79.337 bits (194), Expect = 3.880e-15
Identity = 58/237 (24.47%), Postives = 114/237 (48.10%), Query Frame = 3

Query: 2691 KVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDE--LINFEKLRMMASEIRKLLRMCNTEYNLQSI 3395
            K+ L  ++P   AT+LT++++ L+  I   E ++  +                      N+ G  N  +   N   L N    + +  I  + ++  R++L + F+ VA+ CK+L NF+S+  I++ L  +P+ RLK TW+ V  +   L ++L++L D   NF + R+L L  +++   +P   ++  DL    +GN     +   +INF K   +A+ + +++      Y L+ +
Sbjct: 1298 KLKLLDIDPYTYATQLTVLEHDLYLRITMFECLDRAWGTKY-----------------CNMGGSPNITKFIANANTLTN----FVSHTIVKQADVKTRSKLTQYFVTVAQHCKELNNFSSMTAIVSALYSSPIYRLKKTWDLVSTESKDLLKNLNNLMDSKRNFVKYREL-LRSVTDVACVPFFGVYLSDLTFTFVGNPDFLHNSTNIINFSKRTKIANIVEEIISFKRFHYKLKRL 1512

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BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Yeast
Match: LTE1 (Protein similar to GDP/GTP exchange factors; without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures [Source:SGD;Acc:S000000022])

HSP 1 Score: 56.225 bits (134), Expect = 5.092e-8
Identity = 35/132 (26.52%), Postives = 66/132 (50.00%), Query Frame = 3

Query: 2940 WPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPC---LALHSKDLAAIHLGNKTSTKDELINFEKL 3326
            W  +EI +  +   +  +I++FI VA  C+  +NFN+LM II  L+ + V +    W  +    +  +E+L  +  +  N+  IR L+    S  PL+ C   + ++  DL+A         +D+++N+ K 
Sbjct: 1259 WIISEILLTKSSKMKRNVIQRFIHVADHCRTFQNFNTLMEIILALSSSVVQKFTDAWRLIEPGDLLTWEELKKIPSLDRNYSTIRNLL---NSVNPLVGCVPFIVVYLSDLSANAEKKDWILEDKVVNYNKF 1387

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Nematostella
Match: EDO41810 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S390])

HSP 1 Score: 233.802 bits (595), Expect = 1.421e-63
Identity = 142/349 (40.69%), Postives = 201/349 (57.59%), Query Frame = 3

Query: 2337 SLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYN 3383
            S + +N    ++V+K+Y+ +   +KY +I   TTA+E+V + +  F + Q   +NYSL  VTV+ +    +++  R      +LA ++SLN RYYLKNN   +QL+  +    L  E  VTL Q++  E+A  LTL D+ LFR I   EYI  V+                  ++  NL            FE+ +NRE+FW  TEIC E N+ KR +LIK FIK+AK+CKD KN NS   II+GL  T V RLK TWEK+PN+Y K+YEDL +L D S +  + R L+  E   PPLIP   +  +DL  I+L NK S  D LINFEKLRM+A E+R++ +  +  Y+
Sbjct:  443 STIDQNVEYPDRVVKLYKADQT-YKYFMIFKETTARELVNMAVDAFGL-QDLASNYSLCEVTVEES---GLVRQRRQPDSLANLADRISLNSRYYLKNNNETAQLLQGDATHDLGKECHVTLLQLKTQEVARHLTLQDFELFRAIDPREYIYDVW--------------EFGPEFSPNL----------AKFEETVNRETFWVVTEICGESNVVKRMKLIKHFIKIAKYCKDCKNINSAFAIISGLGHTAVKRLKNTWEKLPNRYYKMYEDLENLMDPSRSMFKYRSLLNSEHVNPPLIPFFPVIKRDLTLIYLNNK-SVVDGLINFEKLRMIAREVRQVSKCHSMPYD 761

HSP 2 Score: 184.496 bits (467), Expect = 1.630e-47
Identity = 119/351 (33.90%), Postives = 197/351 (56.13%), Query Frame = 3

Query:  789 FTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSN-TGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLDDPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLI-GLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL 1835
             T   +  +C VM   +V  +D  +M+DG+ +D+W V+LNG+V +  +N    E   GDSFGV+P++ +  H G M T  + C F C+ Q+ +  I+++  +S I   EE G++ +V E R  S+D  N  G+VV+K  + KLI+ L+ D    DP ++E+FLLT++ F   P  I  KLL  +  E   +D  T+VM     +LW NNH+ D +  +  M +YL+ FE     ++   GQ   +   ACS  +K R I+LE  +++ +   F +  G + G+G+F+ +I+      T G+R+ DQ+L + + S+E I T DKA DLL  +++  + L ++ N   F ++L
Sbjct:    1 MTQNVRRSLCAVMVFAVVEKADAIVMKDGEELDSWCVILNGSVIIEVENEPPIELHLGDSFGVEPSLKKMYHHGLMRTRVNDCQFVCIAQSDYYRILTQG-ESNIQVIEEDGEVVMVTEHR--STDGGNRQGQVVIKAKSGKLITHLVEDHSVIDPTFVEDFLLTFKTFFDQPTKICGKLLNWF-LEDDLRDKVTRVM-----LLWVNNHYNDFEGDHV-MEDYLQAFESALE-VQKMSGQ-LDLLLMACSVKAKSRVISLE-RQSHDQPWGFSIAGGRENGFGIFVYKIDPECSAFTAGVRKADQVLKVNDISFENI-TYDKARDLL--SSSIRLTLALKKNIAGFKDLL 335

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Nematostella
Match: EDO37398 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFW1])

HSP 1 Score: 132.494 bits (332), Expect = 4.889e-31
Identity = 69/150 (46.00%), Postives = 97/150 (64.67%), Query Frame = 3

Query: 2925 NRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNT 3374
            N   +W  TEIC+   ++KR  L+KKFIK+A +CKD KN NS   II  L    +SRL  TWEK+PNKY KLY +L  + D S N  R+ +LV+ ++ +PP+IP + L  KD+  I+ GNKT   +EL+NFEK+RM+   +R L+  C +
Sbjct:  777 NEVHYWVITEICLATQLSKRVFLLKKFIKIASYCKDYKNLNSAFAIIMALNCAAISRLTQTWEKIPNKYKKLYRELDAILDPSGN-HRVYRLVVAKM-KPPVIPFMVLIMKDITIINYGNKTFV-NELVNFEKMRMITISLR-LVEYCRS 922

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Nematostella
Match: EDO40859 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S619])

HSP 1 Score: 78.1814 bits (191), Expect = 8.233e-15
Identity = 53/166 (31.93%), Postives = 86/166 (51.81%), Query Frame = 3

Query: 2856 DYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPN-KYIKLYEDLSDLTDMSLNFRRIRQLVLPEISE-PPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEI 3347
            D+KS L  +     + + + +  NR  +   TEIC+  N   RA++I  FI+VA  C D  NFNS M II G+ ++PV+RLK TW KV N K+ +L  +++  ++ +      +   L +  +   +IP   L  KD+  ++ G      +  INFEK   ++  I
Sbjct:  196 DFKSTL-SYIKRTSSLEAYVEWFNRLGYLVATEICLGHNKKVRAKVIDYFIEVATDCYDRGNFNSAMAIIAGINMSPVARLKKTWSKVKNRKFDRLEREMNPASNFAAYRASFKAAHLRKSDKNEYVIPFFGLFIKDVYFLNEGYSNRHSNGYINFEKFWQLSKLI 360

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Nematostella
Match: EDO32740 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SU64])

HSP 1 Score: 72.4034 bits (176), Expect = 1.091e-12
Identity = 54/213 (25.35%), Postives = 89/213 (41.78%), Query Frame = 3

Query: 2640 DSQLITDEQAKVLLNESKVT--LAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAI 3272
            +SQ +TD++   + N   V   + ++ P   A +LT +D A+F+ I   E+ +  +                                N        N  SFW   EI     +  R  ++  FI++AK   ++ N +SL  +I GL   PV RL  TWE++  +   ++E L DL     N +R+R  +    +  P IP L ++  DL  I
Sbjct:   38 ESQEVTDDEVDAIKNYDAVVFDITKVTPDNFARQLTYMDLAVFKSIQPEEFSSCGWTKKNKSVQS----------------------PNVVALTKRFNHVSFWVVREILNAKKLKTRVAVMSHFIRIAKRLYEMNNLHSLKAVIAGLQSAPVYRLNQTWEQLSRRDHTIFEKLEDLLSEDQNRKRLRDHL--NSTRLPCIPHLGMYLTDLMYI 226

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Nematostella
Match: EDO49269 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RH05])

HSP 1 Score: 66.6254 bits (161), Expect = 8.737e-11
Identity = 47/179 (26.26%), Postives = 80/179 (44.69%), Query Frame = 3

Query: 2916 DLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCI-ITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSL------------------NFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSI 3395
            D  N+ S W    I  E ++ KRA++   FI+ AK C  L+NFN++M I +  L  + + RL  T + VP ++++    +  L D  +                  N+++ R  +    S  P +P   ++ KDL  I  GN    K  L+N  K R +   I ++ +     Y+ Q +
Sbjct: 2036 DRFNQLSTWVVASILTEESVEKRAQMFINFIETAKQCLKLRNFNAVMAIVVAALGSSSIRRLARTKQLVPKEFLEQCAKIEMLMDTKVPALFGLVVGEYLVDVYANNYKKYRTTL--RASPTPAVPYFGIYMKDLTFIAEGNPDFLKGGLVNISKRRQVYIVINEIRQFQKKSYHFQEV 2212

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Medaka
Match: rapgef2 (Rap guanine nucleotide exchange factor 2 [Source:NCBI gene;Acc:101158677])

HSP 1 Score: 447.203 bits (1149), Expect = 1.971e-130
Identity = 310/907 (34.18%), Postives = 487/907 (53.69%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTP--FRLIGLQ-KGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL-----DYFSDAESGIEFDSPTXXXXXXXXXXXXXXQRYSICKDGAXXXXXXXXXXXXXXXXXXXXXWSNSVTLHGISDHVKNGLNCVITPMAVPRP-NEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDL-KAHEECTNDSLMRENQTTV-NQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            D   D + K+P  R + DIE +L+ +  LPAF N T   + ++C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +   +    G+SFGV P M ++   G M T    C F C+ Q ++C I+++ ++  +   EE G+I +V E R L    +  G +V+KGTA++L   L+ +    DP YIE+FLLTYR F+ SP V+  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE++    E   G  + +   AC++ +KPR +TL      SR++P  F L+G Q KG  +FI  +   ++    GL+RGDQIL +   ++E ++ L KA+++L  NT+ SI   V+ N   F E+L     D+ +D E   + D    A     +  + K+ R+SI  D A +   +    +           +N+V   G  + +K   +  +T +  P+P N+  VG                        +S+      ++  KQ+  +  +S     N S+SNPDL ++H       L   NQ  + +QVL+V++ +    +Y++I  +TTAKEVV   I+EF++  +  A YSL  V+V       +IK  R+      LA ++ L+ RYYLK+N+    L +DE A+ LL E +++L Q+  +E+AT+L++  + LF  I   EYI+ +FK                            G  + K FE+ IN E+FW  +E+  EPN  KR ++IK FIK+A  C++ KNF+S+  II+GL L PVSRL+ TWEK+P+KY KL+ DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  266 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRKQLCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDSRTEVLCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQEYCCILNQ-VEKNMQRVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTAERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFH-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFENMLEK-EKMCGHLRLLNI-ACAAKAKPRLVTL---TKPSRDSPLGFSLLGGQEKGSRIFIDAVEPGSKAAEVGLKRGDQILEVNGQNFENVQ-LSKASEILKNNTHLSI--TVKTNLLVFKELLTRPEHDHDTDVED--DHDRKNGAPHQPKIGDIKKASRHSI-PDLAVDVEQVMGLEKASKKAK-----ANTV---GGRNKLKKIFDKTLTSILPPKPYNDVCVG------------------------QSQDDSILGMKQSKQIPPALPVS----GNLSSSNPDLLQSHHRI----LDFNNQPDMSDQVLRVFKADQ-QSRYIMIGKDTTAKEVVVQAIREFALTAAPEA-YSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQDLLREGQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFKRRS-----------------------KTGSASLKRFEEAINHETFWVASEVTREPNQLKRMKIIKHFIKIALHCRECKNFSSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFGDLQDLFDPSRNMAKYRNVLNNQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 1083

HSP 2 Score: 107.071 bits (266), Expect = 1.115e-22
Identity = 47/117 (40.17%), Postives = 73/117 (62.39%), Query Frame = 3

Query:   33 DDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDY 383
            D++F + + + P  RT QD+  + SY   +EAL + +E  +       RYE ++ N  LY   D+ + WYI+LSG V + ++MF PR+SFG RS G++ R  EC++LE +E+IV DY
Sbjct:    6 DNRFRQAVMMNPAERTQQDLEIVYSYLHGMEALSNLREHQLRMMCETVRYERHEANEVLYCPEDIGSCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDY 122

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Medaka
Match: rapgef2 (Rap guanine nucleotide exchange factor 2 [Source:NCBI gene;Acc:101158677])

HSP 1 Score: 446.432 bits (1147), Expect = 3.698e-130
Identity = 331/1028 (32.20%), Postives = 526/1028 (51.17%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTP--FRLIGLQ-KGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL-----DYFSDAESGIEFDSPTXXXXXXXXXXXXXXQRYSICKDGAXXXXXXXXXXXXXXXXXXXXXWSNSVTLHGISDHVKNGLNCVITPMAVPRP-NEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDL-KAHEECT--NDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPNFNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFAXXXXXXXXXXXXXSLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSVDMN 3731
            D   D + K+P  R + DIE +L+ +  LPAF N T   + ++C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +   +    G+SFGV P M ++   G M T    C F C+ Q ++C I+++ ++  +   EE G+I +V E R L    +  G +V+KGTA++L   L+ +    DP YIE+FLLTYR F+ SP V+  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE++    E   G  + +   AC++ +KPR +TL      SR++P  F L+G Q KG  +FI  +   ++    GL+RGDQIL +   ++E ++ L KA+++L  NT+ SI   V+ N   F E+L     D+ +D E   + D    A     +  + K+ R+SI  D A +   +    +           +N+V   G  + +K   +  +T +  P+P N+  VG                        +S+      ++  KQ+  +  +S     N S+SNPDL ++H      N+  +       +QVL+V++ +    +Y++I  +TTAKEVV   I+EF++  +  A YSL  V+V       +IK  R+      LA ++ L+ RYYLK+N+    L +DE A+ LL E +++L Q+  +E+AT+L++  + LF  I   EYI+ +FK                            G  + K FE+ IN E+FW  +E+  EPN  KR ++IK FIK+A  C++ KNF+S+  II+GL L PVSRL+ TWEK+P+KY KL+ DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM                 S+ + P+     F+T     +SL +  A + +    N +  + K+ R +S                   LN         +K+YE+     K + YL NLS++ N
Sbjct:  266 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRKQLCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDSRTEVLCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQEYCCILNQ-VEKNMQRVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTAERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFH-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFENMLEK-EKMCGHLRLLNI-ACAAKAKPRLVTL---TKPSRDSPLGFSLLGGQEKGSRIFIDAVEPGSKAAEVGLKRGDQILEVNGQNFENVQ-LSKASEILKNNTHLSI--TVKTNLLVFKELLTRPEHDHDTDVED--DHDRKNGAPHQPKIGDIKKASRHSI-PDLAVDVEQVMGLEKASKKAK-----ANTV---GGRNKLKKIFDKTLTSILPPKPYNDVCVG------------------------QSQDDSILGMKQSKQIPPALPVS----GNLSSSNPDLLQSHHRILDFNNQPVPVLLNMSDQVLRVFKADQ-QSRYIMIGKDTTAKEVVVQAIREFALTAAPEA-YSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQDLLREGQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFKRRS-----------------------KTGSASLKRFEEAINHETFWVASEVTREPNQLKRMKIIKHFIKIALHCRECKNFSSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFGDLQDLFDPSRNMAKYRNVLNNQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMA----------------SVNMDPA---LMFRT-----RSLSQGSANAAVLDV-NQTGGHKKRVRRSSF------------------LNA--------KKLYEDAQMARKVKQYLSNLSLETN 1157

HSP 2 Score: 107.071 bits (266), Expect = 1.087e-22
Identity = 47/117 (40.17%), Postives = 73/117 (62.39%), Query Frame = 3

Query:   33 DDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDY 383
            D++F + + + P  RT QD+  + SY   +EAL + +E  +       RYE ++ N  LY   D+ + WYI+LSG V + ++MF PR+SFG RS G++ R  EC++LE +E+IV DY
Sbjct:    6 DNRFRQAVMMNPAERTQQDLEIVYSYLHGMEALSNLREHQLRMMCETVRYERHEANEVLYCPEDIGSCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDY 122

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Medaka
Match: rapgef2 (Rap guanine nucleotide exchange factor 2 [Source:NCBI gene;Acc:101158677])

HSP 1 Score: 445.662 bits (1145), Expect = 3.907e-130
Identity = 308/908 (33.92%), Postives = 486/908 (53.52%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTP--FRLIGLQ-KGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL-----DYFSDAESGIEFDSPTXXXXXXXXXXXXXXQRYSICKDGAXXXXXXXXXXXXXXXXXXXXXWSNSVTLHGISDHVKNGLNCVITPMAVPRP-NEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDL-KAHEECT--NDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            D   D + K+P  R + DIE +L+ +  LPAF N T   + ++C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +   +    G+SFGV P M ++   G M T    C F C+ Q ++C I+++ ++  +   EE G+I +V E R L    +  G +V+KGTA++L   L+ +    DP YIE+FLLTYR F+ SP V+  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE++    E   G  + +   AC++ +KPR +TL      SR++P  F L+G Q KG  +FI  +   ++    GL+RGDQIL +   ++E ++ L KA+++L  NT+ SI   V+ N   F E+L     D+ +D E   + D    A     +  + K+ R+SI  D A +   +    +           +N+V   G  + +K   +  +T +  P+P N+  VG                        +S+      ++  KQ+  +  +S     N S+SNPDL ++H      N+  +       +QVL+V++ +    +Y++I  +TTAKEVV   I+EF++  +  A YSL  V+V       +IK  R+      LA ++ L+ RYYLK+N+    L +DE A+ LL E +++L Q+  +E+AT+L++  + LF  I   EYI+ +FK                            G  + K FE+ IN E+FW  +E+  EPN  KR ++IK FIK+A  C++ KNF+S+  II+GL L PVSRL+ TWEK+P+KY KL+ DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  216 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRKQLCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDSRTEVLCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQEYCCILNQ-VEKNMQRVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTAERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFH-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFENMLEK-EKMCGHLRLLNI-ACAAKAKPRLVTL---TKPSRDSPLGFSLLGGQEKGSRIFIDAVEPGSKAAEVGLKRGDQILEVNGQNFENVQ-LSKASEILKNNTHLSI--TVKTNLLVFKELLTRPEHDHDTDVED--DHDRKNGAPHQPKIGDIKKASRHSI-PDLAVDVEQVMGLEKASKKAK-----ANTV---GGRNKLKKIFDKTLTSILPPKPYNDVCVG------------------------QSQDDSILGMKQSKQIPPALPVS----GNLSSSNPDLLQSHHRILDFNNQPVPVLLNMSDQVLRVFKADQ-QSRYIMIGKDTTAKEVVVQAIREFALTAAPEA-YSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQDLLREGQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFKRRS-----------------------KTGSASLKRFEEAINHETFWVASEVTREPNQLKRMKIIKHFIKIALHCRECKNFSSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFGDLQDLFDPSRNMAKYRNVLNNQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 1038

HSP 2 Score: 107.457 bits (267), Expect = 9.797e-23
Identity = 47/117 (40.17%), Postives = 73/117 (62.39%), Query Frame = 3

Query:   33 DDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDY 383
            D++F + + + P  RT QD+  + SY   +EAL + +E  +       RYE ++ N  LY   D+ + WYI+LSG V + ++MF PR+SFG RS G++ R  EC++LE +E+IV DY
Sbjct:    6 DNRFRQAVMMNPAERTQQDLEIVYSYLHGMEALSNLREHQLRMMCETVRYERHEANEVLYCPEDIGSCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDY 122

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Medaka
Match: rapgef2 (Rap guanine nucleotide exchange factor 2 [Source:NCBI gene;Acc:101158677])

HSP 1 Score: 445.277 bits (1144), Expect = 9.115e-130
Identity = 308/908 (33.92%), Postives = 486/908 (53.52%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTP--FRLIGLQ-KGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL-----DYFSDAESGIEFDSPTXXXXXXXXXXXXXXQRYSICKDGAXXXXXXXXXXXXXXXXXXXXXWSNSVTLHGISDHVKNGLNCVITPMAVPRP-NEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDL-KAHEECT--NDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            D   D + K+P  R + DIE +L+ +  LPAF N T   + ++C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +   +    G+SFGV P M ++   G M T    C F C+ Q ++C I+++ ++  +   EE G+I +V E R L    +  G +V+KGTA++L   L+ +    DP YIE+FLLTYR F+ SP V+  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE++    E   G  + +   AC++ +KPR +TL      SR++P  F L+G Q KG  +FI  +   ++    GL+RGDQIL +   ++E ++ L KA+++L  NT+ SI   V+ N   F E+L     D+ +D E   + D    A     +  + K+ R+SI  D A +   +    +           +N+V   G  + +K   +  +T +  P+P N+  VG                        +S+      ++  KQ+  +  +S     N S+SNPDL ++H      N+  +       +QVL+V++ +    +Y++I  +TTAKEVV   I+EF++  +  A YSL  V+V       +IK  R+      LA ++ L+ RYYLK+N+    L +DE A+ LL E +++L Q+  +E+AT+L++  + LF  I   EYI+ +FK                            G  + K FE+ IN E+FW  +E+  EPN  KR ++IK FIK+A  C++ KNF+S+  II+GL L PVSRL+ TWEK+P+KY KL+ DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  266 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRKQLCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDSRTEVLCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQEYCCILNQ-VEKNMQRVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTAERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFH-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFENMLEK-EKMCGHLRLLNI-ACAAKAKPRLVTL---TKPSRDSPLGFSLLGGQEKGSRIFIDAVEPGSKAAEVGLKRGDQILEVNGQNFENVQ-LSKASEILKNNTHLSI--TVKTNLLVFKELLTRPEHDHDTDVED--DHDRKNGAPHQPKIGDIKKASRHSI-PDLAVDVEQVMGLEKASKKAK-----ANTV---GGRNKLKKIFDKTLTSILPPKPYNDVCVG------------------------QSQDDSILGMKQSKQIPPALPVS----GNLSSSNPDLLQSHHRILDFNNQPVPVLLNMSDQVLRVFKADQ-QSRYIMIGKDTTAKEVVVQAIREFALTAAPEA-YSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQDLLREGQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFKRRS-----------------------KTGSASLKRFEEAINHETFWVASEVTREPNQLKRMKIIKHFIKIALHCRECKNFSSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFGDLQDLFDPSRNMAKYRNVLNNQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 1088

HSP 2 Score: 107.457 bits (267), Expect = 1.080e-22
Identity = 47/117 (40.17%), Postives = 73/117 (62.39%), Query Frame = 3

Query:   33 DDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDY 383
            D++F + + + P  RT QD+  + SY   +EAL + +E  +       RYE ++ N  LY   D+ + WYI+LSG V + ++MF PR+SFG RS G++ R  EC++LE +E+IV DY
Sbjct:    6 DNRFRQAVMMNPAERTQQDLEIVYSYLHGMEALSNLREHQLRMMCETVRYERHEANEVLYCPEDIGSCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDY 122

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Medaka
Match: rapgef2 (Rap guanine nucleotide exchange factor 2 [Source:NCBI gene;Acc:101158677])

HSP 1 Score: 445.277 bits (1144), Expect = 9.252e-130
Identity = 308/908 (33.92%), Postives = 486/908 (53.52%), Query Frame = 3

Query:  687 DTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLD-DPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTP--FRLIGLQ-KGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTEFHEIL-----DYFSDAESGIEFDSPTXXXXXXXXXXXXXXQRYSICKDGAXXXXXXXXXXXXXXXXXXXXXWSNSVTLHGISDHVKNGLNCVITPMAVPRP-NEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDL-KAHEECT--NDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCN 3371
            D   D + K+P  R + DIE +L+ +  LPAF N T   + ++C VM   +V  +   ++ DG+ +D+W+V+LNG+VEV + +   +    G+SFGV P M ++   G M T    C F C+ Q ++C I+++ ++  +   EE G+I +V E R L    +  G +V+KGTA++L   L+ +    DP YIE+FLLTYR F+ SP V+  KLL+ +  +P  +D  T+V     ++LW NNHF D + DP   M  +LEEFE++    E   G  + +   AC++ +KPR +TL      SR++P  F L+G Q KG  +FI  +   ++    GL+RGDQIL +   ++E ++ L KA+++L  NT+ SI   V+ N   F E+L     D+ +D E   + D    A     +  + K+ R+SI  D A +   +    +           +N+V   G  + +K   +  +T +  P+P N+  VG                        +S+      ++  KQ+  +  +S     N S+SNPDL ++H      N+  +       +QVL+V++ +    +Y++I  +TTAKEVV   I+EF++  +  A YSL  V+V       +IK  R+      LA ++ L+ RYYLK+N+    L +DE A+ LL E +++L Q+  +E+AT+L++  + LF  I   EYI+ +FK                            G  + K FE+ IN E+FW  +E+  EPN  KR ++IK FIK+A  C++ KNF+S+  II+GL L PVSRL+ TWEK+P+KY KL+ DL DL D S N  + R ++  +  +PP+IP   +  KDL  +H GN +   D L+NFEKLRM+A EIR + RM +
Sbjct:  260 DIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRKQLCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDSRTEVLCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQEYCCILNQ-VEKNMQRVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTAERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFH-DPSLRDKVTRV-----VLLWVNNHFNDFEGDPA--MTRFLEEFENMLEK-EKMCGHLRLLNI-ACAAKAKPRLVTL---TKPSRDSPLGFSLLGGQEKGSRIFIDAVEPGSKAAEVGLKRGDQILEVNGQNFENVQ-LSKASEILKNNTHLSI--TVKTNLLVFKELLTRPEHDHDTDVED--DHDRKNGAPHQPKIGDIKKASRHSI-PDLAVDVEQVMGLEKASKKAK-----ANTV---GGRNKLKKIFDKTLTSILPPKPYNDVCVG------------------------QSQDDSILGMKQSKQIPPALPVS----GNLSSSNPDLLQSHHRILDFNNQPVPVLLNMSDQVLRVFKADQ-QSRYIMIGKDTTAKEVVVQAIREFALTAAPEA-YSLCEVSVTPE---GVIKQRRLPDQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQDLLREGQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFKRRS-----------------------KTGSASLKRFEEAINHETFWVASEVTREPNQLKRMKIIKHFIKIALHCRECKNFSSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFGDLQDLFDPSRNMAKYRNVLNNQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGRMAS 1082

HSP 2 Score: 107.071 bits (266), Expect = 1.097e-22
Identity = 47/117 (40.17%), Postives = 73/117 (62.39%), Query Frame = 3

Query:   33 DDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDY 383
            D++F + + + P  RT QD+  + SY   +EAL + +E  +       RYE ++ N  LY   D+ + WYI+LSG V + ++MF PR+SFG RS G++ R  EC++LE +E+IV DY
Sbjct:    6 DNRFRQAVMMNPAERTQQDLEIVYSYLHGMEALSNLREHQLRMMCETVRYERHEANEVLYCPEDIGSCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDY 122

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Planmine SMEST
Match: SMESG000033489.1 (SMESG000033489.1)

HSP 1 Score: 1712.58 bits (4434), Expect = 0.000e+0
Identity = 944/944 (100.00%), Postives = 944/944 (100.00%), Query Frame = 3

Query: 2022 SNSVTLHGISDHVKNGLNCVITPMAVPRPNEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDLKAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPNFNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFAXXXXXXXXXXXXXSLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSVDMNIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXALNDSPAVDQGAADVKSITQKSPVPSNANQTKXXXXXXXXXXXXXXXXXXXXXXXXXXCKPRSRPQSIFSNQNPEDVQKIMNLVSTTRNVPRKQQPITPTDRESGVRIRAVRVGAEHNYLRNVPLFNSKEGENVIRELTSRYHKPKDANNSNFIPGGITLNLHQNLVPQIDKTKHANVYQYPPAGVPLNNLFYAGDRKRCMKPDLPSYETARAMIQQHRLNNISYTDYNTKPIMLPTVVPTAKEMGALKPPISANKRPNLPSYNQHLSRTTQSNQDIYLSQTLVTKRNVXXXXXRTVTVQKSNSSQIPNYLQVNKPNSKEYIYDISHKYFQSLNECDEIIQL 4853
            SNSVTLHGISDHVKNGLNCVITPMAVPRPNEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDLKAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFKLPPLKDDDKKALDPSLEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPNFNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFALKGTLKKKTVKRKSLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSVDMNISHLQELSLSLEPSSSSVTNSIISNSSNSSTTALNDSPAVDQGAADVKSITQKSPVPSNANQTKPIATSPPPLPLSPVSSASSQNSVIRSCKPRSRPQSIFSNQNPEDVQKIMNLVSTTRNVPRKQQPITPTDRESGVRIRAVRVGAEHNYLRNVPLFNSKEGENVIRELTSRYHKPKDANNSNFIPGGITLNLHQNLVPQIDKTKHANVYQYPPAGVPLNNLFYAGDRKRCMKPDLPSYETARAMIQQHRLNNISYTDYNTKPIMLPTVVPTAKEMGALKPPISANKRPNLPSYNQHLSRTTQSNQDIYLSQTLVTKRNVPPPPPRTVTVQKSNSSQIPNYLQVNKPNSKEYIYDISHKYFQSLNECDEIIQL
Sbjct:   37 SNSVTLHGISDHVKNGLNCVITPMAVPRPNEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDLKAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFKLPPLKDDDKKALDPSLEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPNFNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFALKGTLKKKTVKRKSLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSVDMNISHLQELSLSLEPSSSSVTNSIISNSSNSSTTALNDSPAVDQGAADVKSITQKSPVPSNANQTKPIATSPPPLPLSPVSSASSQNSVIRSCKPRSRPQSIFSNQNPEDVQKIMNLVSTTRNVPRKQQPITPTDRESGVRIRAVRVGAEHNYLRNVPLFNSKEGENVIRELTSRYHKPKDANNSNFIPGGITLNLHQNLVPQIDKTKHANVYQYPPAGVPLNNLFYAGDRKRCMKPDLPSYETARAMIQQHRLNNISYTDYNTKPIMLPTVVPTAKEMGALKPPISANKRPNLPSYNQHLSRTTQSNQDIYLSQTLVTKRNVPPPPPRTVTVQKSNSSQIPNYLQVNKPNSKEYIYDISHKYFQSLNECDEIIQL 980

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Planmine SMEST
Match: SMESG000033489.1 (SMESG000033489.1)

HSP 1 Score: 1666.36 bits (4314), Expect = 0.000e+0
Identity = 921/921 (100.00%), Postives = 921/921 (100.00%), Query Frame = 3

Query: 2091 MAVPRPNEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDLKAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPNFNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFAXXXXXXXXXXXXXSLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSVDMNIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXALNDSPAVDQGAADVKSITQKSPVPSNANQTKXXXXXXXXXXXXXXXXXXXXXXXXXXCKPRSRPQSIFSNQNPEDVQKIMNLVSTTRNVPRKQQPITPTDRESGVRIRAVRVGAEHNYLRNVPLFNSKEGENVIRELTSRYHKPKDANNSNFIPGGITLNLHQNLVPQIDKTKHANVYQYPPAGVPLNNLFYAGDRKRCMKPDLPSYETARAMIQQHRLNNISYTDYNTKPIMLPTVVPTAKEMGALKPPISANKRPNLPSYNQHLSRTTQSNQDIYLSQTLVTKRNVXXXXXRTVTVQKSNSSQIPNYLQVNKPNSKEYIYDISHKYFQSLNECDEIIQL 4853
            MAVPRPNEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDLKAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFKLPPLKDDDKKALDPSLEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPNFNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFALKGTLKKKTVKRKSLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSVDMNISHLQELSLSLEPSSSSVTNSIISNSSNSSTTALNDSPAVDQGAADVKSITQKSPVPSNANQTKPIATSPPPLPLSPVSSASSQNSVIRSCKPRSRPQSIFSNQNPEDVQKIMNLVSTTRNVPRKQQPITPTDRESGVRIRAVRVGAEHNYLRNVPLFNSKEGENVIRELTSRYHKPKDANNSNFIPGGITLNLHQNLVPQIDKTKHANVYQYPPAGVPLNNLFYAGDRKRCMKPDLPSYETARAMIQQHRLNNISYTDYNTKPIMLPTVVPTAKEMGALKPPISANKRPNLPSYNQHLSRTTQSNQDIYLSQTLVTKRNVPPPPPRTVTVQKSNSSQIPNYLQVNKPNSKEYIYDISHKYFQSLNECDEIIQL
Sbjct:    1 MAVPRPNEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDLKAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFKLPPLKDDDKKALDPSLEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPNFNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFALKGTLKKKTVKRKSLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSVDMNISHLQELSLSLEPSSSSVTNSIISNSSNSSTTALNDSPAVDQGAADVKSITQKSPVPSNANQTKPIATSPPPLPLSPVSSASSQNSVIRSCKPRSRPQSIFSNQNPEDVQKIMNLVSTTRNVPRKQQPITPTDRESGVRIRAVRVGAEHNYLRNVPLFNSKEGENVIRELTSRYHKPKDANNSNFIPGGITLNLHQNLVPQIDKTKHANVYQYPPAGVPLNNLFYAGDRKRCMKPDLPSYETARAMIQQHRLNNISYTDYNTKPIMLPTVVPTAKEMGALKPPISANKRPNLPSYNQHLSRTTQSNQDIYLSQTLVTKRNVPPPPPRTVTVQKSNSSQIPNYLQVNKPNSKEYIYDISHKYFQSLNECDEIIQL 921

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Planmine SMEST
Match: SMESG000033489.1 (SMESG000033489.1)

HSP 1 Score: 1664.05 bits (4308), Expect = 0.000e+0
Identity = 921/922 (99.89%), Postives = 922/922 (100.00%), Query Frame = 3

Query: 2022 SNSVTLHGISDHVKNGLNCVITPMAVPRPNEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDLKAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPNFNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFAXXXXXXXXXXXXXSLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSVDMNIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXALNDSPAVDQGAADVKSITQKSPVPSNANQTKXXXXXXXXXXXXXXXXXXXXXXXXXXCKPRSRPQSIFSNQNPEDVQKIMNLVSTTRNVPRKQQPITPTDRESGVRIRAVRVGAEHNYLRNVPLFNSKEGENVIRELTSRYHKPKDANNSNFIPGGITLNLHQNLVPQIDKTKHANVYQYPPAGVPLNNLFYAGDRKRCMKPDLPSYETARAMIQQHRLNNISYTDYNTKPIMLPTVVPTAKEMGALKPPISANKRPNLPSYNQHLSRTTQSNQDIYLSQTLVTKRNVXXXXXRTVTVQKSNSSQIPNYLQVNKPNSKE 4787
            SNSVTLHGISDHVKNGLNCVITPMAVPRPNEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDLKAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFKLPPLKDDDKKALDPSLEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPNFNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFALKGTLKKKTVKRKSLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSVDMNISHLQELSLSLEPSSSSVTNSIISNSSNSSTTALNDSPAVDQGAADVKSITQKSPVPSNANQTKPIATSPPPLPLSPVSSASSQNSVIRSCKPRSRPQSIFSNQNPEDVQKIMNLVSTTRNVPRKQQPITPTDRESGVRIRAVRVGAEHNYLRNVPLFNSKEGENVIRELTSRYHKPKDANNSNFIPGGITLNLHQNLVPQIDKTKHANVYQYPPAGVPLNNLFYAGDRKRCMKPDLPSYETARAMIQQHRLNNISYTDYNTKPIMLPTVVPTAKEMGALKPPISANKRPNLPSYNQHLSRTTQSNQDIYLSQTLVTKRNVPPPPPRTVTVQKSNSSQIPNYLQVNKPNSK+
Sbjct:   37 SNSVTLHGISDHVKNGLNCVITPMAVPRPNEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDLKAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFKLPPLKDDDKKALDPSLEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPNFNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFALKGTLKKKTVKRKSLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSVDMNISHLQELSLSLEPSSSSVTNSIISNSSNSSTTALNDSPAVDQGAADVKSITQKSPVPSNANQTKPIATSPPPLPLSPVSSASSQNSVIRSCKPRSRPQSIFSNQNPEDVQKIMNLVSTTRNVPRKQQPITPTDRESGVRIRAVRVGAEHNYLRNVPLFNSKEGENVIRELTSRYHKPKDANNSNFIPGGITLNLHQNLVPQIDKTKHANVYQYPPAGVPLNNLFYAGDRKRCMKPDLPSYETARAMIQQHRLNNISYTDYNTKPIMLPTVVPTAKEMGALKPPISANKRPNLPSYNQHLSRTTQSNQDIYLSQTLVTKRNVPPPPPRTVTVQKSNSSQIPNYLQVNKPNSKD 958

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Planmine SMEST
Match: SMESG000033489.1 (SMESG000033489.1)

HSP 1 Score: 1644.4 bits (4257), Expect = 0.000e+0
Identity = 915/922 (99.24%), Postives = 916/922 (99.35%), Query Frame = 3

Query: 2022 SNSVTLHGISDHVKNGLNCVITPMAVPRPNEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDLKAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFXXXXXXXXXXXXXXXXXEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPNFNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFAXXXXXXXXXXXXXSLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSVDMNIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXALNDSPAVDQGAADVKSITQKSPVPSNANQTKXXXXXXXXXXXXXXXXXXXXXXXXXXCKPRSRPQSIFSNQNPEDVQKIMNLVSTTRNVPRKQQPITPTDRESGVRIRAVRVGAEHNYLRNVPLFNSKEGENVIRELTSRYHKPKDANNSNFIPGGITLNLHQNLVPQIDKTKHANVYQYPPAGVPLNNLFYAGDRKRCMKPDLPSYETARAMIQQHRLNNISYTDYNTKPIMLPTVVPTAKEMGALKPPISANKRPNLPSYNQHLSRTTQSNQDIYLSQTLVTKRNVXXXXXRTVTVQKSNSSQIPNYLQVNKPNSKE 4787
            SNSVTLHGISDHVKNGLNCVITPMAVPRPNEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDLKAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFKLPPLKDDDKKALDPSLEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPNFNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFALKGTLKKKTVKRKSLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSVDMNISHLQELSLSLEPSSSSVTNSIISNSSNSSTTALNDSPAVDQGAADVKSITQKSPVPSNANQTKPIATSPPPLPLSPVSSASSQNSVIRSCKPRSRPQSIFSNQNPEDVQKIMNLVSTTRNVPRKQQPITPTDRESGVRIRAVRVGAEHNYLRNVPLFNSKEGENVIRELTSRYHKPKDANNSNFIPGGITLNLHQNLVPQIDKTKHANVYQYPPAGVPLNNLFYAGDRKRCMKPDLPSYETARAMIQQHRLN      YNTKPIMLPTVVPTAKEMGALKPPISANKRPNLPSYNQHLSRTTQSNQDIYLSQTLVTKRNVPPPPPRTVTVQKSNSSQIPNYLQVNKPNSK+
Sbjct:   37 SNSVTLHGISDHVKNGLNCVITPMAVPRPNEFIVGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQGALNNRSTSNPDLKAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVLITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVALYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPIEIATRLTLIDYALFRDIPSAEYINYVFKLPPLKDDDKKALDPSLEDYKSNLEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAKFCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDMSLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFEKLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPNFNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFALKGTLKKKTVKRKSLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSVDMNISHLQELSLSLEPSSSSVTNSIISNSSNSSTTALNDSPAVDQGAADVKSITQKSPVPSNANQTKPIATSPPPLPLSPVSSASSQNSVIRSCKPRSRPQSIFSNQNPEDVQKIMNLVSTTRNVPRKQQPITPTDRESGVRIRAVRVGAEHNYLRNVPLFNSKEGENVIRELTSRYHKPKDANNSNFIPGGITLNLHQNLVPQIDKTKHANVYQYPPAGVPLNNLFYAGDRKRCMKPDLPSYETARAMIQQHRLN------YNTKPIMLPTVVPTAKEMGALKPPISANKRPNLPSYNQHLSRTTQSNQDIYLSQTLVTKRNVPPPPPRTVTVQKSNSSQIPNYLQVNKPNSKD 952

[Close]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Planmine SMEST
Match: SMESG000033486.1 (SMESG000033486.1)

HSP 1 Score: 1169.45 bits (3024), Expect = 0.000e+0
Identity = 599/600 (99.83%), Postives = 599/600 (99.83%), Query Frame = 3

Query:   21 MEEADDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDYSLETYTQPTTMTRKHSSNTESIKELEISNNSTITLTTPSPNNLFNNGTIXXXXXXXXXXXXXXXGCDALAGNSVGNXXXXXXXXXXXXXXXXXXXXIYSMSDTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLDDPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLIGLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTE 1820
            MEEADDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDYSLETYTQPTTMTRKHSSNTESIKELEISNNSTITLTTPSPNNLFNNGTISKRSSHASDTSSAYSGCDALAGNSVGNASFASDNEDDDADLDSLSQDIYSMSDTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLDDPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLIGLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNP E
Sbjct:    1 MEEADDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSRIARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHGNIYRYDECVILEKTELIVFDYSLETYTQPTTMTRKHSSNTESIKELEISNNSTITLTTPSPNNLFNNGTISKRSSHASDTSSAYSGCDALAGNSVGNASFASDNEDDDADLDSLSQDIYSMSDTFYDVILKEPNLRNESDIETILDGVQHLPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVEVRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFCEIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLISLLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKTKVMIRKILILWANNHFIDLDDPNSDMCEYLEEFEDIFSNIEYSIGQDKSVFFRACSSNSKPRYITLEVNKNYSRNTPFRLIGLQKGWGLFIKEINRLTQRKTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPLE 600

The following BLAST results are available for this feature:

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Human
BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Celegans
BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Fly
BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Zebrafish
BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Xenopus
BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Mouse
BLAST of Rap guanine nucleotide exchange factor 2 vs. UniProt/SwissProt
BLAST of Rap guanine nucleotide exchange factor 2 vs. TrEMBL
BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Cavefish
BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Sea Lamprey
BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Yeast
BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Nematostella
BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Medaka
BLAST of Rap guanine nucleotide exchange factor 2 vs. Planmine SMEST

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
RAPGEF2	9.543e-66	40.06	Rap guanine nucleotide exchange factor 2 [Source:H...	[more]
RAPGEF2	1.198e-65	40.06	Rap guanine nucleotide exchange factor 2 [Source:H...	[more]
RAPGEF2	1.346e-65	40.06	Rap guanine nucleotide exchange factor 2 [Source:H...	[more]
RAPGEF6	7.110e-63	37.73	Rap guanine nucleotide exchange factor 6 [Source:H...	[more]
RAPGEF6	4.055e-62	38.63	Rap guanine nucleotide exchange factor 6 [Source:H...	[more]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pxf-1	5.581e-60	38.08	Rap guanine nucleotide exchange factor [Source:Un...	[more]
pxf-1	5.581e-60	38.08	Rap guanine nucleotide exchange factor [Source:Un...	[more]
pxf-1	6.602e-60	37.50	Rap guanine nucleotide exchange factor [Source:Un...	[more]
pxf-1	6.602e-60	37.50	Rap guanine nucleotide exchange factor [Source:Un...	[more]
pxf-1	8.399e-60	37.50	Rap guanine nucleotide exchange factor [Source:Un...	[more]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PDZ-GEF	3.599e-70	36.42	gene:FBgn0265778 transcript:FBtr0300039	[more]
PDZ-GEF	4.210e-70	36.42	gene:FBgn0265778 transcript:FBtr0079249	[more]
PDZ-GEF	6.049e-70	36.42	gene:FBgn0265778 transcript:FBtr0333242	[more]
PDZ-GEF	6.049e-70	36.42	gene:FBgn0265778 transcript:FBtr0300038	[more]
Epac	2.998e-31	28.85	gene:FBgn0085421 transcript:FBtr0112636	[more]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rapgef2	1.300e-64	40.82	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
rapgef2	1.424e-64	40.82	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
rapgef2	1.608e-64	40.82	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
rapgef2	1.903e-64	40.82	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
rapgef2	2.198e-64	40.82	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rapgef2	4.815e-67	41.16	cathepsin K-like [Source:Xenbase;Acc:XB-GENE-98681...	[more]
rapgef2	4.827e-67	41.16	cathepsin K-like [Source:Xenbase;Acc:XB-GENE-98681...	[more]
rapgef2	5.184e-67	41.16	cathepsin K-like [Source:Xenbase;Acc:XB-GENE-98681...	[more]
rapgef2	7.293e-67	41.16	cathepsin K-like [Source:Xenbase;Acc:XB-GENE-98681...	[more]
rapgef2	7.544e-67	41.16	cathepsin K-like [Source:Xenbase;Acc:XB-GENE-98681...	[more]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Rapgef2	4.617e-66	40.06	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
Rapgef2	7.317e-66	40.06	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
Rapgef2	1.087e-65	40.06	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
Rapgef6	1.118e-65	38.99	Rap guanine nucleotide exchange factor (GEF) 6 [So...	[more]
Rapgef6	1.297e-65	40.28	Rap guanine nucleotide exchange factor (GEF) 6 [So...	[more]

BLAST of Rap guanine nucleotide exchange factor 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q8CHG7\|RPGF2_MOUSE	3.230e-65	40.06	Rap guanine nucleotide exchange factor 2 OS=Mus mu...	[more]
sp\|F1M386\|RPGF2_RAT	4.074e-65	40.06	Rap guanine nucleotide exchange factor 2 OS=Rattus...	[more]
sp\|Q9Y4G8\|RPGF2_HUMAN	4.583e-65	40.06	Rap guanine nucleotide exchange factor 2 OS=Homo s...	[more]
sp\|F1PBJ0\|RPGF2_CANLF	5.386e-65	40.06	Rap guanine nucleotide exchange factor 2 OS=Canis ...	[more]
sp\|F1MSG6\|RPGF2_BOVIN	8.366e-65	40.06	Rap guanine nucleotide exchange factor 2 OS=Bos ta...	[more]

BLAST of Rap guanine nucleotide exchange factor 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A3B1IKT1	2.517e-130	34.07	Rap guanine nucleotide exchange factor (GEF) 2 OS=...	[more]
A0A3B4ELQ4	4.564e-129	34.77	Rap guanine nucleotide exchange factor (GEF) 2 OS=...	[more]
A0A3B4ELP0	8.597e-129	34.62	Rap guanine nucleotide exchange factor (GEF) 2 OS=...	[more]
A0A3B4DC63	8.903e-129	34.62	Rap guanine nucleotide exchange factor (GEF) 2 OS=...	[more]
A0A3B4DC09	1.584e-128	34.62	Rap guanine nucleotide exchange factor (GEF) 2 OS=...	[more]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rapgef2	9.535e-134	34.07	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
rapgef6	7.874e-68	39.34	Rap guanine nucleotide exchange factor (GEF) 6 [So...	[more]
rapgef2	3.097e-66	40.27	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
si:dkey-253i9.4	1.270e-63	35.58	si:dkey-253i9.4 [Source:ZFIN;Acc:ZDB-GENE-090313-2...	[more]
ENSAMXT00000037388.1	1.270e-44	33.13	pep primary_assembly:Astyanax_mexicanus-2.0:APWO02...	[more]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rapgef2	4.413e-61	36.09	Rap guanine nucleotide exchange factor (GEF) 2 [So...	[more]
ENSPMAT00000005082.1	2.803e-42	36.05	pep scaffold:Pmarinus_7.0:GL478314:141397:156611:1...	[more]
ENSPMAT00000005209.1	5.789e-8	28.10	pep scaffold:Pmarinus_7.0:GL478155:18709:35318:-1 ...	[more]
rgl1	6.919e-6	35.14	ral guanine nucleotide dissociation stimulator-lik...	[more]
sos2	9.026e-6	24.64	son of sevenless homolog 2 (Drosophila) [Source:ZF...	[more]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2


Match Name	E-value	Identity	Description
CDC25	3.880e-15	24.47	Membrane bound guanine nucleotide exchange factor;...	[more]
LTE1	5.092e-8	26.52	Protein similar to GDP/GTP exchange factors; witho...	[more]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO41810	1.421e-63	40.69	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37398	4.889e-31	46.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO40859	8.233e-15	31.93	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO32740	1.091e-12	25.35	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49269	8.737e-11	26.26	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rapgef2	1.971e-130	34.18	Rap guanine nucleotide exchange factor 2 [Source:N...	[more]
rapgef2	3.698e-130	32.20	Rap guanine nucleotide exchange factor 2 [Source:N...	[more]
rapgef2	3.907e-130	33.92	Rap guanine nucleotide exchange factor 2 [Source:N...	[more]
rapgef2	9.115e-130	33.92	Rap guanine nucleotide exchange factor 2 [Source:N...	[more]
rapgef2	9.252e-130	33.92	Rap guanine nucleotide exchange factor 2 [Source:N...	[more]

BLAST of Rap guanine nucleotide exchange factor 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000033489.1	0.000e+0	100.00	SMESG000033489.1	[more]
SMESG000033489.1	0.000e+0	100.00	SMESG000033489.1	[more]
SMESG000033489.1	0.000e+0	99.89	SMESG000033489.1	[more]
SMESG000033489.1	0.000e+0	99.24	SMESG000033489.1	[more]
SMESG000033486.1	0.000e+0	99.83	SMESG000033486.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30024929 ID=SMED30024929|Name=Rap guanine nucleotide exchange factor 2|organism=Schmidtea mediterranea sexual|type=transcript|length=4980bp
AATCTTATATGGAATAATAAATGGAAGAGGCAGATGATAAATTTGTCAAA
TGCTTGTCAGTGCCACCAAATTTAAGAACACTTCAAGATGTTCATTGTAT
TCGATCATATTTTAAAAGTATTGAAGCACTTAAAAGTTTCAAAGAATTAA
CAATATCAGAATTTTCAAGAATCGCCAGATATGAGCATTATCAACCTAAT
GCAACTTTATATAGAAGAGGAGATGTTTGCACCTCGTGGTATATTGTTCT
CTCAGGGTGTGTTTTAGTTGGTCAAACAATGTTTTTTCCTAGAACTAGTT
TTGGGCATCGATCACATGGAAACATTTATCGTTATGATGAATGCGTAATT
TTAGAGAAAACCGAATTAATTGTGTTTGATTATTCACTTGAAACATATAC
TCAACCGACAACTATGACAAGGAAACACAGCTCGAACACAGAATCCATCA
AAGAATTAGAAATATCAAATAATTCAACCATAACATTAACAACACCTTCA
CCAAATAATCTATTCAACAATGGGACTATCAGCAAGCGATCCTCTCATGC
AAGCGATACATCGAGTGCCTATTCCGGTTGTGATGCTTTAGCAGGAAATT
CTGTAGGAAATGCATCATTTGCTTCCGACAACGAAGATGATGATGCAGAT
CTCGATAGTCTTAGTCAGGATATATATTCAATGAGTGACACGTTCTATGA
TGTAATTCTCAAAGAACCAAATTTACGAAATGAATCAGACATCGAGACTA
TCTTAGACGGCGTTCAACATCTACCAGCATTCTTGAATTTTACCTCGAAA
ACGAAATATGAAATATGTAAAGTGATGCAAGTAGTTATGGTTCATAATTC
TGATGAAAAACTGATGGAAGACGGTCAAGTTATGGATACATGGAATGTGG
TTTTAAATGGAACCGTAGAAGTACGTTTCAAAAACGGATCTATTAAAGAG
TATACTAGAGGAGATAGTTTTGGTGTCCAACCAAATATGAACGAACAGAA
GCATACCGGTGAAATGTGGACCGTGTCTTCAAGCTGCATGTTTTGCTGTG
TACTTCAAGCTCAATTCTGCGAAATTGTCAGTCGAAATATTGATTCCATA
ATTCCGGAAAGAGAAGAAAGTGGAAAAATTGATTTGGTTTACGAAGAAAG
GCCACTGTCTTCTGATTCATCAAATACTGGAAAAGTGGTGGTTAAGGGAA
CCGCTGATAAATTGATTAGTCTTTTAATGGTTGATCAGCGTAAATATGAT
CCTATGTACATTGAAAATTTTTTGCTTACCTATCGTGTCTTTGTTAAATC
TCCTAAAGTAATTGCTGACAAACTTCTTCAGTGCTATCAAGCAGAACCAC
AAGATAAAGATAGCAAAACAAAAGTTATGATTAGAAAAATTTTGATATTG
TGGGCAAATAACCATTTTATTGATTTGGACGATCCCAATTCCGACATGTG
TGAATATTTAGAGGAATTTGAAGATATATTTAGCAACATCGAATATTCAA
TTGGCCAGGACAAATCAGTATTTTTCCGTGCTTGTAGCAGCAATTCCAAA
CCAAGGTATATTACTTTGGAAGTAAACAAAAACTATTCCAGAAATACTCC
TTTCCGATTGATTGGATTGCAAAAAGGCTGGGGTCTATTTATCAAAGAAA
TAAATAGATTAACACAGAGAAAGACGTTTGGTTTAAGACGAGGAGATCAA
ATTCTTTCTTTGGCTAATCATTCATGGGAAAGAATCGAAACACTTGATAA
AGCTACTGATTTGCTCAATCCGAATACCAATTGCTCTATTGAACTTGTTG
TTCGATATAATCCAACTGAGTTTCATGAAATTCTGGATTATTTTTCTGAT
GCAGAATCTGGAATTGAATTTGATTCTCCAACAACTGCCTCTTTAGCACT
ATTGTTGAAAACACTGTACAAGTCGCAGAGATATTCCATATGCAAAGATG
GAGCATCAAATAGATATAATATTAACAGTCGACTAAGGCGACGATTGTCT
CTAAGTAAAAATGTTAATTGGTCTAACAGTGTTACTCTACATGGCATTAG
TGACCATGTTAAAAATGGTCTTAATTGCGTTATAACTCCAATGGCGGTTC
CTAGACCAAATGAGTTTATTGTCGGTTCACCCCCAATGCGAATGAGATCC
AATCCCCGAAGTGCACATACATCTCCTACCAGGCATACAGTTAGAGCTAA
AAGCAAAGCAAAATATAGTCCTTCAGTAGAAAATGATAAACAAGTAACTC
TTTCAAGACAGTTAAGTCAAGGCGCTCTTAATAATCGTTCTACGTCAAAT
CCTGATTTAAAAGCTCATGAAGAGTGTACAAATGATTCCCTAATGAGAGA
AAACCAAACAACTGTAAATCAAGTTTTAAAAGTTTACAGGCCAAATTCAG
TGGATTTTAAATACGTTTTGATTACTAACAATACAACAGCTAAAGAAGTA
GTGCCTCTCATAATTAAAGAATTCTCCATTGATCAATCAGAACTAGCCAA
TTATTCGCTATACACGGTCACAGTTGATAGTAACTTAAACGGACCAATTA
TAAAAAGTAGTCGTGTTGCTCTTTATTTCAAAGATCTAGCTGGAAAATTA
TCTCTCAATCAGAGATATTATCTGAAAAACAATATAACGGACAGTCAATT
AATCACAGATGAACAGGCTAAAGTTTTGTTAAATGAATCGAAAGTTACGC
TTGCTCAGATGGAACCTATTGAAATAGCAACTCGTTTAACGTTGATTGAT
TATGCTCTTTTTCGAGATATTCCATCTGCGGAATATATAAATTACGTTTT
TAAATTACCGCCTTTGAAGGATGATGATAAAAAAGCACTCGATCCTTCTT
TAGAAGATTACAAATCTAATTTAGAAGGATTTTCGAATGGTTACGAAAAT
TATAAAAATTTCGAAGACCTCATCAATCGTGAGTCATTCTGGCCAACCAC
TGAGATTTGCATGGAACCTAATATTAATAAGAGAGCTGAATTGATTAAGA
AATTTATCAAAGTGGCAAAGTTCTGTAAAGATCTAAAAAATTTCAATTCG
CTCATGTGCATTATTACCGGGCTAACATTGACTCCCGTGAGTCGATTAAA
ATTAACATGGGAAAAAGTGCCTAATAAATATATAAAGTTATACGAAGATT
TAAGCGATCTAACCGACATGAGCTTGAATTTTCGACGCATTCGCCAACTC
GTTTTGCCTGAAATTAGTGAGCCGCCATTAATACCTTGTTTGGCACTCCA
CTCAAAAGATTTGGCTGCTATTCACTTGGGTAACAAAACTTCTACAAAGG
ATGAACTTATAAATTTTGAGAAACTTCGTATGATGGCATCAGAGATAAGG
AAACTTCTTCGAATGTGCAACACTGAATATAATCTCCAAAGCATATTGTC
TTCAGTCAAAAATCGAAGTATCCAATTGAAACCGTCAAGTGATATATTCA
ATTTTCAAACGTCACCTAATTTTAACCAATCCCTGGATGAATCTGACGCC
ACAAGTGGCATATCAGGATGCAGTAATAATTCGGATAGTTACATAAAAAA
AGGTCGTTCTAATTCGGTTGATCAATTCGCGCTGAAAGGAACATTAAAAA
AGAAGACTGTTAAAAGGAAATCATTAAACGTATCTGAGAATAATATTAAA
ACTCCGAGAAAAATCTACGAAGAGTGGCTGTCAACTCTAAAATTTCGAAC
ATACCTGATGAATTTATCAGTAGACATGAATATAAGTCATTTACAAGAGC
TTTCATTAAGTTTGGAACCTTCTAGTTCCTCTGTTACTAATTCAATAATA
TCAAATAGCTCAAATTCATCAACGACAGCTTTAAACGACAGTCCAGCTGT
CGACCAGGGCGCTGCAGATGTGAAATCAATTACTCAAAAGTCACCAGTTC
CATCTAATGCAAATCAAACAAAACCCATTGCAACCTCGCCACCTCCTTTG
CCGCTTTCACCAGTTTCAAGTGCTTCCTCGCAAAACAGTGTAATTAGAAG
CTGTAAACCTCGAAGTCGGCCGCAATCTATTTTTAGTAACCAAAACCCTG
AAGATGTTCAAAAAATAATGAACCTTGTTTCAACTACTCGAAATGTGCCT
AGAAAGCAGCAACCAATAACTCCCACTGACAGAGAATCCGGTGTACGAAT
ACGTGCTGTTCGTGTGGGCGCTGAACACAATTATTTAAGAAATGTTCCTC
TTTTCAATTCTAAAGAAGGAGAGAATGTCATTCGAGAACTAACATCAAGA
TACCATAAACCTAAGGATGCAAACAATTCTAACTTTATTCCTGGAGGTAT
AACACTAAATCTTCATCAAAATCTTGTTCCACAGATCGATAAAACTAAAC
ATGCAAATGTTTATCAGTATCCACCAGCTGGCGTCCCTTTAAACAATCTA
TTCTATGCAGGAGATCGGAAGAGATGCATGAAACCCGATTTGCCATCGTA
TGAAACTGCTAGAGCAATGATTCAACAGCATAGATTAAATAATATATCTT
ATACAGACTATAATACCAAGCCTATTATGCTTCCTACAGTCGTTCCTACT
GCTAAAGAAATGGGAGCTTTAAAACCTCCCATATCTGCAAATAAACGTCC
AAACCTTCCATCATACAATCAACATCTCTCTCGAACAACTCAATCTAATC
AAGATATTTACCTTTCACAAACATTAGTAACCAAACGCAATGTGCCACCA
CCTCCACCTCGAACTGTCACTGTCCAGAAGTCAAACTCAAGTCAAATCCC
AAATTATCTTCAAGTGAATAAACCCAATAGTAAAGAATATATTTACGATA
TTAGTCACAAATATTTTCAAAGCCTCAACGAATGTGATGAAATTATTCAG
TTATAGATATTTTGAAATATTAATTATTTATGACACGTCTCATTAGCACT
AATTATGAGATTATATATTGTAATAATTGTAAATAATTCGATAATTTTGA
GCCGTTCATTTGCTCTTCATTTTGTAATAG

protein sequence of SMED30024929-orf-1

>SMED30024929-orf-1 ID=SMED30024929-orf-1|Name=SMED30024929-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1612bp
MEEADDKFVKCLSVPPNLRTLQDVHCIRSYFKSIEALKSFKELTISEFSR
IARYEHYQPNATLYRRGDVCTSWYIVLSGCVLVGQTMFFPRTSFGHRSHG
NIYRYDECVILEKTELIVFDYSLETYTQPTTMTRKHSSNTESIKELEISN
NSTITLTTPSPNNLFNNGTISKRSSHASDTSSAYSGCDALAGNSVGNASF
ASDNEDDDADLDSLSQDIYSMSDTFYDVILKEPNLRNESDIETILDGVQH
LPAFLNFTSKTKYEICKVMQVVMVHNSDEKLMEDGQVMDTWNVVLNGTVE
VRFKNGSIKEYTRGDSFGVQPNMNEQKHTGEMWTVSSSCMFCCVLQAQFC
EIVSRNIDSIIPEREESGKIDLVYEERPLSSDSSNTGKVVVKGTADKLIS
LLMVDQRKYDPMYIENFLLTYRVFVKSPKVIADKLLQCYQAEPQDKDSKT
KVMIRKILILWANNHFIDLDDPNSDMCEYLEEFEDIFSNIEYSIGQDKSV
FFRACSSNSKPRYITLEVNKNYSRNTPFRLIGLQKGWGLFIKEINRLTQR
KTFGLRRGDQILSLANHSWERIETLDKATDLLNPNTNCSIELVVRYNPTE
FHEILDYFSDAESGIEFDSPTTASLALLLKTLYKSQRYSICKDGASNRYN
INSRLRRRLSLSKNVNWSNSVTLHGISDHVKNGLNCVITPMAVPRPNEFI
VGSPPMRMRSNPRSAHTSPTRHTVRAKSKAKYSPSVENDKQVTLSRQLSQ
GALNNRSTSNPDLKAHEECTNDSLMRENQTTVNQVLKVYRPNSVDFKYVL
ITNNTTAKEVVPLIIKEFSIDQSELANYSLYTVTVDSNLNGPIIKSSRVA
LYFKDLAGKLSLNQRYYLKNNITDSQLITDEQAKVLLNESKVTLAQMEPI
EIATRLTLIDYALFRDIPSAEYINYVFKLPPLKDDDKKALDPSLEDYKSN
LEGFSNGYENYKNFEDLINRESFWPTTEICMEPNINKRAELIKKFIKVAK
FCKDLKNFNSLMCIITGLTLTPVSRLKLTWEKVPNKYIKLYEDLSDLTDM
SLNFRRIRQLVLPEISEPPLIPCLALHSKDLAAIHLGNKTSTKDELINFE
KLRMMASEIRKLLRMCNTEYNLQSILSSVKNRSIQLKPSSDIFNFQTSPN
FNQSLDESDATSGISGCSNNSDSYIKKGRSNSVDQFALKGTLKKKTVKRK
SLNVSENNIKTPRKIYEEWLSTLKFRTYLMNLSVDMNISHLQELSLSLEP
SSSSVTNSIISNSSNSSTTALNDSPAVDQGAADVKSITQKSPVPSNANQT
KPIATSPPPLPLSPVSSASSQNSVIRSCKPRSRPQSIFSNQNPEDVQKIM
NLVSTTRNVPRKQQPITPTDRESGVRIRAVRVGAEHNYLRNVPLFNSKEG
ENVIRELTSRYHKPKDANNSNFIPGGITLNLHQNLVPQIDKTKHANVYQY
PPAGVPLNNLFYAGDRKRCMKPDLPSYETARAMIQQHRLNNISYTDYNTK
PIMLPTVVPTAKEMGALKPPISANKRPNLPSYNQHLSRTTQSNQDIYLSQ
TLVTKRNVPPPPPRTVTVQKSNSSQIPNYLQVNKPNSKEYIYDISHKYFQ
SLNECDEIIQL*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000020	protonephridia
PLANA:0000034	epidermis
PLANA:0000101	muscle cell
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036964	RASGEF_cat_dom_sf
IPR008937	Ras-like_GEF
IPR001895	RASGEF_cat_dom
IPR000651	Ras-like_Gua-exchang_fac_N
IPR014710	RmlC-like_jellyroll
IPR000595	cNMP-bd_dom
IPR018490	cNMP-bd-like
IPR029071	Ubiquitin-like_domsf
IPR023578	Ras_GEF_dom_sf

Vocabulary: **biological process**
Term	Definition
GO:0007264	small GTPase mediated signal transduction
GO:0007165	signal transduction
GO:0043547	positive regulation of GTPase activity

Vocabulary: **molecular function**
Term	Definition
GO:0005085	guanyl-nucleotide exchange factor activity

Vocabulary: **cellular component**
Term	Definition
GO:0005622	intracellular

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	SMART	SM00147	RasGEF_3	coord: 204..471 e-value: 9.7E-59 score: 211.1
IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	PFAM	PF00617	RasGEF	coord: 211..413 e-value: 1.4E-43 score: 149.1
IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	PROSITE	PS50009	RASGEF_CAT	coord: 208..460 score: 55.952
IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	CDD	cd00155	RasGEF	coord: 206..434 e-value: 1.34494E-59 score: 201.327
IPR036964	Ras guanine-nucleotide exchange factor catalytic domain superfamily	GENE3D	G3DSA:1.10.840.10		coord: 198..464 e-value: 9.6E-67 score: 226.9
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1..71
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 569..632
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 569..585
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 594..613
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 45..70
None	No IPR available	PANTHER	PTHR23113:SF249	DIZZY ISOFORM AII	coord: 69..749
None	No IPR available	CDD	cd01785	RA_PDZ-GEF1	coord: 94..181 e-value: 7.89237E-25 score: 96.9952
IPR008937	Ras-like guanine nucleotide exchange factor	PANTHER	PTHR23113	GUANINE NUCLEOTIDE EXCHANGE FACTOR	coord: 69..749
IPR023578	Ras guanine nucleotide exchange factor domain superfamily	SUPERFAMILY	SSF48366	Ras GEF	coord: 182..569
IPR029071	Ubiquitin-like domain superfamily	SUPERFAMILY	SSF54236	Ubiquitin-like	coord: 95..149