C2H2-type domain-containing protein

Overview


Name	C2H2-type domain-containing protein
Smed ID	SMED30024902
Length (bp)	1835

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of C2H2-type domain-containing protein (SMED30024902) t-SNE clustered cells

Violin plots show distribution of expression levels for C2H2-type domain-containing protein (SMED30024902) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of C2H2-type domain-containing protein (SMED30024902) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for C2H2-type domain-containing protein (SMED30024902) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30024902

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 8

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X1 cell	SMED30024902	SMESG000014973.1	SmedASXL_005598	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30024902	SMESG000014973.1	SmedASXL_005598	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
nervous system	SMED30024902	SMESG000014973.1	dd_Smed_v4_11893_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30024902	SMESG000014973.1	dd_Smed_v4_11893_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30024902	SMESG000014973.1	dd_Smed_v4_11893_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cilated neuron	SMED30024902	SMESG000014973.1	dd_Smed_v4_11893_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30024902	SMESG000014973.1	dd_Smed_v6_11893_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
Category 3 cell	SMED30024902	SMESG000014973.1	dd_Smed_v4_11893_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Human
Match: IKZF1 (IKAROS family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:13176])

HSP 1 Score: 63.5438 bits (153), Expect = 1.385e-10
Identity = 22/49 (44.90%), Postives = 33/49 (67.35%), Query Frame = 2

Query: 1526 KLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            K++KC HC++LF D   Y +HMG H   +P++CNMCG    D ++F+ H
Sbjct:  190 KVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSH 238

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Human
Match: IKZF1 (IKAROS family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:13176])

HSP 1 Score: 63.5438 bits (153), Expect = 1.843e-10
Identity = 22/49 (44.90%), Postives = 33/49 (67.35%), Query Frame = 2

Query: 1526 KLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            K++KC HC++LF D   Y +HMG H   +P++CNMCG    D ++F+ H
Sbjct:  209 KVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSH 257

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Human
Match: IKZF1 (IKAROS family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:13176])

HSP 1 Score: 63.929 bits (154), Expect = 1.863e-10
Identity = 22/49 (44.90%), Postives = 33/49 (67.35%), Query Frame = 2

Query: 1526 KLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            K++KC HC++LF D   Y +HMG H   +P++CNMCG    D ++F+ H
Sbjct:  235 KVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSH 283

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Human
Match: IKZF1 (IKAROS family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:13176])

HSP 1 Score: 63.5438 bits (153), Expect = 3.444e-10
Identity = 39/120 (32.50%), Postives = 60/120 (50.00%), Query Frame = 2

Query: 1313 TISNNTEDEILERKCRSAPLYNTNLDEKSVSSLNNDSEDKHQKSQSDVMANGEGSPNLLKECVDNDIQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            T SNN E        RS  +Y TN    +  + N  S  +  ++   + A  E S + L+    +  Q   K++KC HC++LF D   Y +HMG H   +P++CNMCG    D ++F+ H
Sbjct:  217 TESNNEEQ-------RSGLIYLTN--HIAPHARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQM--KVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSH 325

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Human
Match: IKZF1 (IKAROS family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:13176])

HSP 1 Score: 63.5438 bits (153), Expect = 4.275e-10
Identity = 22/49 (44.90%), Postives = 33/49 (67.35%), Query Frame = 2

Query: 1526 KLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            K++KC HC++LF D   Y +HMG H   +P++CNMCG    D ++F+ H
Sbjct:  317 KVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSH 365

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Celegans
Match: ehn-3 (Enhancer of HAND mutation hnd-1 [Source:UniProtKB/TrEMBL;Acc:Q9N4M6])

HSP 1 Score: 50.8322 bits (120), Expect = 6.787e-7
Identity = 19/48 (39.58%), Postives = 32/48 (66.67%), Query Frame = 2

Query: 1538 CNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVHSLH 1681
            C++CKI F+D   + LH GLH+ + P++C++CG  C   +DF  H ++
Sbjct:  166 CDYCKIRFDDKVMWYLHSGLHSDDIPFKCSLCGSLCDGKYDFAAHLVY 213

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Celegans
Match: ehn-3 (Enhancer of HAND mutation hnd-1 [Source:UniProtKB/TrEMBL;Acc:Q9N4M6])

HSP 1 Score: 49.6766 bits (117), Expect = 9.603e-7
Identity = 19/45 (42.22%), Postives = 30/45 (66.67%), Query Frame = 2

Query: 1538 CNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            C++CKI F+D   + LH GLH+ + P++C++CG  C   +DF  H
Sbjct:  123 CDYCKIRFDDKVMWYLHSGLHSDDIPFKCSLCGSLCDGKYDFAAH 167

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Celegans
Match: ehn-3 (Enhancer of HAND mutation hnd-1 [Source:UniProtKB/TrEMBL;Acc:Q9N4M6])

HSP 1 Score: 50.447 bits (119), Expect = 1.377e-6
Identity = 19/48 (39.58%), Postives = 32/48 (66.67%), Query Frame = 2

Query: 1538 CNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVHSLH 1681
            C++CKI F+D   + LH GLH+ + P++C++CG  C   +DF  H ++
Sbjct:  210 CDYCKIRFDDKVMWYLHSGLHSDDIPFKCSLCGSLCDGKYDFAAHLVY 257

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Celegans
Match: ztf-16 (Zinc finger putative Transcription Factor family [Source:UniProtKB/TrEMBL;Acc:H2L008])

HSP 1 Score: 51.2174 bits (121), Expect = 1.472e-6
Identity = 19/48 (39.58%), Postives = 31/48 (64.58%), Query Frame = 2

Query: 1535 KCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVHSL 1678
            +C HC ++F D T Y LH  LH+  +P++C +CG +C + + FT H +
Sbjct:  421 ECCHCGMMFYDNTMYLLHKSLHSDGDPFKCALCGTQCGEKYMFTTHVI 468

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Fly
Match: hb (gene:FBgn0001180 transcript:FBtr0081951)

HSP 1 Score: 56.225 bits (134), Expect = 7.561e-8
Identity = 20/48 (41.67%), Postives = 32/48 (66.67%), Query Frame = 2

Query: 1529 LHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            +++C +C I F+DA  Y +HMG H+ ++ ++CNMCG+KC       VH
Sbjct:  704 IYECKYCDIFFKDAVLYTIHMGYHSCDDVFKCNMCGEKCDGPVGLFVH 751

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Fly
Match: hb (gene:FBgn0001180 transcript:FBtr0081950)

HSP 1 Score: 56.225 bits (134), Expect = 7.561e-8
Identity = 20/48 (41.67%), Postives = 32/48 (66.67%), Query Frame = 2

Query: 1529 LHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            +++C +C I F+DA  Y +HMG H+ ++ ++CNMCG+KC       VH
Sbjct:  704 IYECKYCDIFFKDAVLYTIHMGYHSCDDVFKCNMCGEKCDGPVGLFVH 751

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Fly
Match: CG12769 (gene:FBgn0033252 transcript:FBtr0088827)

HSP 1 Score: 53.9138 bits (128), Expect = 3.789e-7
Identity = 25/60 (41.67%), Postives = 37/60 (61.67%), Query Frame = 2

Query: 1502 DNDIQFLSKL-HKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVHSL 1678
            D D+    KL   C+ C I F D T Y LH G H  +NPW+CN+CG++ +++++F  H L
Sbjct:  638 DGDLLINRKLILTCHFCGIEFPDETLYFLHKGCHCESNPWRCNICGEQLNNVYEFNSHLL 697

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Fly
Match: CG12769 (gene:FBgn0033252 transcript:FBtr0088828)

HSP 1 Score: 53.9138 bits (128), Expect = 3.931e-7
Identity = 25/60 (41.67%), Postives = 37/60 (61.67%), Query Frame = 2

Query: 1502 DNDIQFLSKL-HKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVHSL 1678
            D D+    KL   C+ C I F D T Y LH G H  +NPW+CN+CG++ +++++F  H L
Sbjct:  642 DGDLLINRKLILTCHFCGIEFPDETLYFLHKGCHCESNPWRCNICGEQLNNVYEFNSHLL 701

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Fly
Match: CG12769 (gene:FBgn0033252 transcript:FBtr0339281)

HSP 1 Score: 53.9138 bits (128), Expect = 3.980e-7
Identity = 25/60 (41.67%), Postives = 37/60 (61.67%), Query Frame = 2

Query: 1502 DNDIQFLSKL-HKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVHSL 1678
            D D+    KL   C+ C I F D T Y LH G H  +NPW+CN+CG++ +++++F  H L
Sbjct:  649 DGDLLINRKLILTCHFCGIEFPDETLYFLHKGCHCESNPWRCNICGEQLNNVYEFNSHLL 708

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Zebrafish
Match: ikzf5 (IKAROS family zinc finger 5 [Source:NCBI gene;Acc:402893])

HSP 1 Score: 64.3142 bits (155), Expect = 1.668e-10
Identity = 25/54 (46.30%), Postives = 32/54 (59.26%), Query Frame = 2

Query: 1511 IQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            +Q    LH C HC I F D   Y +HMG H   NP+QCN+CG +C + +DF  H
Sbjct:  359 VQDPQMLHHCPHCHIYFPDNILYTIHMGCHGYENPFQCNICGHRCRNSYDFACH 412

[Close]

Query: 1511 IQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            +Q    LH C HC I F D   Y +HMG H   NP+QCN+CG +C + +DF  H
Sbjct:  359 VQDPQMLHHCPHCHIYFPDNILYTIHMGCHGYENPFQCNICGHRCRNSYDFACH 412

[Close]

Query: 1511 IQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            +Q    LH C HC I F D   Y +HMG H   NP+QCN+CG +C + +DF  H
Sbjct:  359 VQDPQMLHHCPHCHIYFPDNILYTIHMGCHGYENPFQCNICGHRCRNSYDFACH 412

[Close]

Query: 1511 IQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            +Q    LH C HC I F D   Y +HMG H   NP+QCN+CG +C + +DF  H
Sbjct:  359 VQDPQMLHHCPHCHIYFPDNILYTIHMGCHGYENPFQCNICGHRCRNSYDFACH 412

[Close]

Query: 1511 IQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            +Q    LH C HC I F D   Y +HMG H   NP+QCN+CG +C + +DF  H
Sbjct:  359 VQDPQMLHHCPHCHIYFPDNILYTIHMGCHGYENPFQCNICGHRCRNSYDFACH 412

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Xenopus
Match: six3 (SIX homeobox 3 [Source:Xenbase;Acc:XB-GENE-478761])

HSP 1 Score: 64.3142 bits (155), Expect = 2.672e-10
Identity = 22/49 (44.90%), Postives = 34/49 (69.39%), Query Frame = 2

Query: 1526 KLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            K+HKC HC+++F D   Y +HMG H   +P++CNMCG +  D ++F+ H
Sbjct:  395 KVHKCEHCRVIFLDHVMYTIHMGCHGFRDPFECNMCGYQSQDRYEFSSH 443

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Xenopus
Match: six3 (SIX homeobox 3 [Source:Xenbase;Acc:XB-GENE-478761])

HSP 1 Score: 64.3142 bits (155), Expect = 3.848e-10
Identity = 22/49 (44.90%), Postives = 34/49 (69.39%), Query Frame = 2

Query: 1526 KLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            K+HKC HC+++F D   Y +HMG H   +P++CNMCG +  D ++F+ H
Sbjct:  477 KVHKCEHCRVIFLDHVMYTIHMGCHGFRDPFECNMCGYQSQDRYEFSSH 525

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Xenopus
Match: ikzf5 (IKAROS family zinc finger 5 [Source:NCBI gene;Acc:550109])

HSP 1 Score: 62.7734 bits (151), Expect = 8.214e-10
Identity = 24/48 (50.00%), Postives = 30/48 (62.50%), Query Frame = 2

Query: 1529 LHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            LH C HC + F D   Y +HMG H   NP+QCN+CG KC + +DF  H
Sbjct:  382 LHHCQHCDMYFADNILYTIHMGCHGFENPFQCNICGCKCKNKYDFACH 429

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Xenopus
Match: ikzf5 (IKAROS family zinc finger 5 [Source:NCBI gene;Acc:550109])

HSP 1 Score: 62.7734 bits (151), Expect = 8.333e-10
Identity = 24/48 (50.00%), Postives = 30/48 (62.50%), Query Frame = 2

Query: 1529 LHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            LH C HC + F D   Y +HMG H   NP+QCN+CG KC + +DF  H
Sbjct:  382 LHHCQHCDMYFADNILYTIHMGCHGFENPFQCNICGCKCKNKYDFACH 429

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Xenopus
Match: TRPS1 (transcriptional repressor GATA binding 1 [Source:NCBI gene;Acc:100493561])

HSP 1 Score: 60.4622 bits (145), Expect = 7.509e-9
Identity = 35/81 (43.21%), Postives = 46/81 (56.79%), Query Frame = 2

Query: 1436 QKSQSDVMANGEGSPNLLK-ECVDNDIQ-FLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            +KS+S + A  +G  N+ K E  D   Q  LS   KC HC I+F D   Y LHM  H  N P+QC++C   C+D +DFT H
Sbjct:  917 EKSKSPLSAKDDGPLNVTKIEKSDKSTQDELST--KCVHCGIVFLDEVMYALHMSCHGENGPFQCSICQHLCTDKYDFTTH 995

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Mouse
Match: Ikzf5 (IKAROS family zinc finger 5 [Source:MGI Symbol;Acc:MGI:1914393])

HSP 1 Score: 65.0846 bits (157), Expect = 3.785e-11
Identity = 25/54 (46.30%), Postives = 33/54 (61.11%), Query Frame = 2

Query: 1511 IQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            +Q    LH C HC + F D   Y +HMG H  ++P+QCN+CG KC D +DF  H
Sbjct:  204 VQDPQLLHHCQHCDVYFADNVLYTVHMGCHGYDSPFQCNVCGCKCKDKYDFACH 257

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Mouse
Match: Ikzf5 (IKAROS family zinc finger 5 [Source:MGI Symbol;Acc:MGI:1914393])

HSP 1 Score: 64.6994 bits (156), Expect = 1.509e-10
Identity = 25/54 (46.30%), Postives = 33/54 (61.11%), Query Frame = 2

Query: 1511 IQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            +Q    LH C HC + F D   Y +HMG H  ++P+QCN+CG KC D +DF  H
Sbjct:  357 VQDPQLLHHCQHCDVYFADNVLYTVHMGCHGYDSPFQCNVCGCKCKDKYDFACH 410

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Mouse
Match: Ikzf1 (IKAROS family zinc finger 1 [Source:MGI Symbol;Acc:MGI:1342540])

HSP 1 Score: 62.7734 bits (151), Expect = 5.986e-10
Identity = 22/49 (44.90%), Postives = 33/49 (67.35%), Query Frame = 2

Query: 1526 KLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            K++KC HC++LF D   Y +HMG H   +P++CNMCG    D ++F+ H
Sbjct:  369 KVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSH 417

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Mouse
Match: Ikzf1 (IKAROS family zinc finger 1 [Source:MGI Symbol;Acc:MGI:1342540])

HSP 1 Score: 62.7734 bits (151), Expect = 7.910e-10
Identity = 22/49 (44.90%), Postives = 33/49 (67.35%), Query Frame = 2

Query: 1526 KLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            K++KC HC++LF D   Y +HMG H   +P++CNMCG    D ++F+ H
Sbjct:  476 KVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSH 524

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Mouse
Match: Ikzf1 (IKAROS family zinc finger 1 [Source:MGI Symbol;Acc:MGI:1342540])

HSP 1 Score: 62.7734 bits (151), Expect = 8.349e-10
Identity = 22/49 (44.90%), Postives = 33/49 (67.35%), Query Frame = 2

Query: 1526 KLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            K++KC HC++LF D   Y +HMG H   +P++CNMCG    D ++F+ H
Sbjct:  456 KVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSH 504

[Close]

BLAST of C2H2-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8BU00|IKZF5_MOUSE (Zinc finger protein Pegasus OS=Mus musculus OX=10090 GN=Ikzf5 PE=2 SV=1)

HSP 1 Score: 64.6994 bits (156), Expect = 1.056e-9
Identity = 25/54 (46.30%), Postives = 33/54 (61.11%), Query Frame = 2

Query: 1511 IQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            +Q    LH C HC + F D   Y +HMG H  ++P+QCN+CG KC D +DF  H
Sbjct:  357 VQDPQLLHHCQHCDVYFADNVLYTVHMGCHGYDSPFQCNVCGCKCKDKYDFACH 410

[Close]

BLAST of C2H2-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6DBW0|IKZF5_DANRE (Zinc finger protein Pegasus OS=Danio rerio OX=7955 GN=ikzf5 PE=2 SV=1)

HSP 1 Score: 64.3142 bits (155), Expect = 1.259e-9
Identity = 25/54 (46.30%), Postives = 32/54 (59.26%), Query Frame = 2

Query: 1511 IQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            +Q    LH C HC I F D   Y +HMG H   NP+QCN+CG +C + +DF  H
Sbjct:  359 VQDPQMLHHCPHCHIYFPDNILYTIHMGCHGYENPFQCNICGHRCRNSYDFACH 412

[Close]

BLAST of C2H2-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5ZLR2|IKZF5_CHICK (Zinc finger protein Pegasus OS=Gallus gallus OX=9031 GN=IKZF5 PE=2 SV=1)

HSP 1 Score: 63.5438 bits (153), Expect = 2.096e-9
Identity = 24/48 (50.00%), Postives = 30/48 (62.50%), Query Frame = 2

Query: 1529 LHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            LH C HC + F D   Y +HMG H   NP+QCN+CG KC + +DF  H
Sbjct:  365 LHHCQHCDMYFADNILYTIHMGCHGFENPFQCNICGCKCKNKYDFACH 412

[Close]

BLAST of C2H2-type domain-containing protein vs. UniProt/SwissProt
Match: sp|O42410|IKZF1_CHICK (DNA-binding protein Ikaros OS=Gallus gallus OX=9031 GN=IKZF1 PE=2 SV=1)

HSP 1 Score: 63.929 bits (154), Expect = 2.119e-9
Identity = 30/82 (36.59%), Postives = 46/82 (56.10%), Query Frame = 2

Query: 1430 KHQKSQSDVMANG-EGSPNLLKECVDNDIQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            K +  Q DV+  G + S +  K    N  Q   +++KC HC++LF D   Y +HMG H   +P++CNMCG    D ++F+ H
Sbjct:  428 KEESRQFDVLRAGTDNSQDAFKVISSNGEQV--RVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSH 507

[Close]

BLAST of C2H2-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6NRM0|IKZF5_XENLA (Zinc finger protein Pegasus OS=Xenopus laevis OX=8355 GN=ikzf5 PE=2 SV=1)

HSP 1 Score: 63.5438 bits (153), Expect = 2.632e-9
Identity = 25/54 (46.30%), Postives = 32/54 (59.26%), Query Frame = 2

Query: 1511 IQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            +Q    LH C HC + F D   Y +HMG H   NP+QCN+CG KC + +DF  H
Sbjct:  376 VQDPQLLHHCQHCDMYFADNILYTIHMGCHGFENPFQCNICGCKCKNKYDFACH 429

[Close]

BLAST of C2H2-type domain-containing protein vs. TrEMBL
Match: A0A1S3KDL6 (zinc finger protein 423 OS=Lingula unguis OX=7574 GN=LOC106181024 PE=4 SV=1)

HSP 1 Score: 90.5077 bits (223), Expect = 4.609e-15
Identity = 75/280 (26.79%), Postives = 122/280 (43.57%), Query Frame = 2

Query:  914 SANGT--NTFSDISRERIQAPCFICKICGETFINLDSLAMHMFIHVQQETNPNKEVPGHQKSTHPXXXXXXPIL-STNSVMPLPESIWSNHLNSSLYFKSLLTTSLIDPNKLQLELSRASDLFTT------GKIQSLTKFNSTISNNTEDEILE----RKCRSAPLYNTNLDEKSV---SSLNNDSEDKHQKSQSDVM----ANGEGSPNLLKE---CVDNDIQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVHSLHF 1684
            +A GT     +D+ R  +Q    +C  CG  F +LD+LAMHM  H   +    ++    +   H     ++P+      +     SI  + L   +      + S+++   +   L + S             +QS   F+  ++       L        +SA  Y  +    SV   ++ +  S+     S++  M     +GE SP+   E    VD  ++    L  C HCKI+F + T Y LHMGLHN+NN WQCN+CG+ C D  +F+ H +HF
Sbjct:  455 AAPGTVSQQRADMHRGNMQ----VCGQCGMIFTSLDALAMHMMTHAHHDMEDVEKERRQRGEGHSLWNSKEPMQPQVKRLRAASASIAGDALPLHIKRTRPASASMVEDMSVGASLRKVSSPHKAVPPKCPASLQSHPAFSEPVNFAHHSRALSLVPSASNKSAHTYEKSHTPSSVHVPATRSARSDCSTPLSETAQMNPDTTHGEASPSTSGETSSIVDFVLENRESLKMCRHCKIVFAEKTLYYLHMGLHNLNNAWQCNLCGRICRDAREFSAHVIHF 730

[Close]

BLAST of C2H2-type domain-containing protein vs. TrEMBL
Match: A0A0L8I0P1 (Uncharacterized protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22039808mg PE=4 SV=1)

HSP 1 Score: 84.7297 bits (208), Expect = 2.689e-13
Identity = 31/49 (63.27%), Postives = 40/49 (81.63%), Query Frame = 2

Query: 1538 CNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVHSLHF 1684
            C HC ++F +   Y LHMGLHNVNNPWQCN+CGK C+D+H+FT H++HF
Sbjct:  587 CKHCDVIFLNRILYHLHMGLHNVNNPWQCNICGKVCNDVHNFTTHAIHF 635

[Close]

BLAST of C2H2-type domain-containing protein vs. TrEMBL
Match: K1QP68 (C2H2-type domain-containing protein OS=Crassostrea gigas OX=29159 GN=CGI_10020807 PE=4 SV=1)

HSP 1 Score: 78.5666 bits (192), Expect = 3.916e-13
Identity = 30/51 (58.82%), Postives = 40/51 (78.43%), Query Frame = 2

Query: 1529 LHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVHSLH 1681
            ++ C  C+I+F + TT+ LH GLHNVNNPWQCNMCG+  SD+HDF+ H +H
Sbjct:  129 VYFCRFCEIIFLNRTTFYLHKGLHNVNNPWQCNMCGQTFSDVHDFSAHVIH 179

[Close]

BLAST of C2H2-type domain-containing protein vs. TrEMBL
Match: V4AEJ5 (C2H2-type domain-containing protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_121808 PE=4 SV=1)

HSP 1 Score: 73.9442 bits (180), Expect = 1.685e-12
Identity = 35/72 (48.61%), Postives = 47/72 (65.28%), Query Frame = 2

Query: 1469 EGSPNLLKECVDNDIQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVHSLHF 1684
            E +PN+ KE + +     S    C +C+I++ D T Y LHMGLHNVNNPWQCN CGK C +  +F+ H LH+
Sbjct:   17 ESNPNIPKELLASR----SISCYCQYCEIIYLDRTIYQLHMGLHNVNNPWQCNACGKVCENRLEFSSHVLHY 84

[Close]

BLAST of C2H2-type domain-containing protein vs. TrEMBL
Match: T1G783 (C2H2-type domain-containing protein OS=Helobdella robusta OX=6412 GN=20216930 PE=4 SV=1)

HSP 1 Score: 72.7886 bits (177), Expect = 1.685e-12
Identity = 28/49 (57.14%), Postives = 39/49 (79.59%), Query Frame = 2

Query: 1538 CNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVHSLHF 1684
            C HC+++F + T+Y LHMGLHN+N+PWQCN+CG KCSD   F+ H +H+
Sbjct:    2 CVHCELIFSEKTSYYLHMGLHNINDPWQCNLCGLKCSDSQSFSSHVMHY 50

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Cavefish
Match: ikzf1 (IKAROS family zinc finger 1 (Ikaros) [Source:ZFIN;Acc:ZDB-GENE-980526-304])

HSP 1 Score: 60.077 bits (144), Expect = 2.647e-9
Identity = 19/49 (38.78%), Postives = 33/49 (67.35%), Query Frame = 2

Query: 1526 KLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            + ++C HC++LF D   Y +HMG H   +P++CN+CG +  D ++F+ H
Sbjct:  298 RAYRCVHCRVLFLDHVMYTIHMGCHGFRDPFECNLCGYRSQDRYEFSSH 346

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Cavefish
Match: ikzf1 (IKAROS family zinc finger 1 (Ikaros) [Source:ZFIN;Acc:ZDB-GENE-980526-304])

HSP 1 Score: 59.6918 bits (143), Expect = 2.849e-9
Identity = 19/49 (38.78%), Postives = 33/49 (67.35%), Query Frame = 2

Query: 1526 KLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            + ++C HC++LF D   Y +HMG H   +P++CN+CG +  D ++F+ H
Sbjct:  280 RAYRCVHCRVLFLDHVMYTIHMGCHGFRDPFECNLCGYRSQDRYEFSSH 328

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Cavefish
Match: IKZF5 (zinc finger protein Pegasus-like [Source:NCBI gene;Acc:103042963])

HSP 1 Score: 60.077 bits (144), Expect = 2.998e-9
Identity = 22/48 (45.83%), Postives = 30/48 (62.50%), Query Frame = 2

Query: 1529 LHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            L  C+HC++ F D   Y +HMG H    P+QCN+CG +C D +DF  H
Sbjct:  352 LFSCSHCQVYFADNILYTIHMGCHGYEKPFQCNVCGCQCRDRYDFACH 399

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Cavefish
Match: ikzf5 (zinc finger protein Pegasus [Source:NCBI gene;Acc:103043326])

HSP 1 Score: 58.9214 bits (141), Expect = 7.006e-9
Identity = 22/48 (45.83%), Postives = 29/48 (60.42%), Query Frame = 2

Query: 1529 LHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            L  C HC I F D   Y +HMG H   NP++CN+CG +C + +DF  H
Sbjct:  362 LQHCPHCHIYFPDNILYTIHMGCHGYENPFKCNICGYRCRNKYDFACH 409

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Cavefish
Match: ikzf1 (IKAROS family zinc finger 1 (Ikaros) [Source:ZFIN;Acc:ZDB-GENE-980526-304])

HSP 1 Score: 59.3066 bits (142), Expect = 7.384e-9
Identity = 19/49 (38.78%), Postives = 33/49 (67.35%), Query Frame = 2

Query: 1526 KLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            + ++C HC++LF D   Y +HMG H   +P++CN+CG +  D ++F+ H
Sbjct:  461 RAYRCVHCRVLFLDHVMYTIHMGCHGFRDPFECNLCGYRSQDRYEFSSH 509

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000869.1 (pep scaffold:Pmarinus_7.0:GL476362:938611:940054:-1 gene:ENSPMAG00000000793.1 transcript:ENSPMAT00000000869.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 62.7734 bits (151), Expect = 5.759e-11
Identity = 21/49 (42.86%), Postives = 32/49 (65.31%), Query Frame = 2

Query: 1526 KLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            + +KC HC++LF D   Y +HMG H   +P++CNMCG    D ++F+ H
Sbjct:  244 RAYKCQHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSH 292

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000367.1 (pep scaffold:Pmarinus_7.0:GL480594:46543:47925:-1 gene:ENSPMAG00000000331.1 transcript:ENSPMAT00000000367.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 62.7734 bits (151), Expect = 5.811e-11
Identity = 24/50 (48.00%), Postives = 32/50 (64.00%), Query Frame = 2

Query: 1523 SKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            ++ H+C HC I F D   Y +HMG H   NP+QCN+CG  C D +DF+ H
Sbjct:  266 TEAHQCPHCDIYFPDNILYTIHMGCHGYENPFQCNVCGYCCHDRYDFSCH 315

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005061.1 (pep scaffold:Pmarinus_7.0:GL476392:809231:810583:1 gene:ENSPMAG00000004600.1 transcript:ENSPMAT00000005061.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 58.9214 bits (141), Expect = 1.130e-9
Identity = 22/47 (46.81%), Postives = 30/47 (63.83%), Query Frame = 2

Query: 1532 HKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            H C HC I F D   + +HMG H  +NP+ CN+CG++C D +DF  H
Sbjct:  269 HTCPHCGIWFPDNVLFTIHMGCHGHDNPFWCNLCGRRCHDRYDFNCH 315

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ikzf4 (IKAROS family zinc finger 4 [Source:ZFIN;Acc:ZDB-GENE-180319-1])

HSP 1 Score: 58.9214 bits (141), Expect = 2.124e-9
Identity = 27/97 (27.84%), Postives = 47/97 (48.45%), Query Frame = 2

Query: 1403 SSLNNDSEDKHQKSQSDVMANGEGSP-------NLLKECVDNDIQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            SS   D+     +     +  G G P        L    +  D +++ + + C HC+++F D   Y LHMG H   +P++CN+CG +  D ++F+ H
Sbjct:  401 SSATQDAASTPAREDVPQLQEGGGQPRPPASEGGLAYRVMGPDGEYM-RAYNCLHCQVIFLDHVMYTLHMGCHGFRDPFECNVCGHRSRDRYEFSSH 496

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ikzf4 (IKAROS family zinc finger 4 [Source:ZFIN;Acc:ZDB-GENE-180319-1])

HSP 1 Score: 58.9214 bits (141), Expect = 2.167e-9
Identity = 27/97 (27.84%), Postives = 47/97 (48.45%), Query Frame = 2

Query: 1403 SSLNNDSEDKHQKSQSDVMANGEGSP-------NLLKECVDNDIQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            SS   D+     +     +  G G P        L    +  D +++ + + C HC+++F D   Y LHMG H   +P++CN+CG +  D ++F+ H
Sbjct:  483 SSATQDAASTPAREDVPQLQEGGGQPRPPASEGGLAYRVMGPDGEYM-RAYNCLHCQVIFLDHVMYTLHMGCHGFRDPFECNVCGHRSRDRYEFSSH 578

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Medaka
Match: ikzf5 (zinc finger protein Pegasus [Source:NCBI gene;Acc:101167144])

HSP 1 Score: 64.3142 bits (155), Expect = 1.438e-10
Identity = 25/48 (52.08%), Postives = 29/48 (60.42%), Query Frame = 2

Query: 1529 LHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            LH C HC I F D   Y +HMG H   NP+QCN+CG KC   +DF  H
Sbjct:  364 LHHCQHCDIYFPDNILYTIHMGCHGYENPFQCNICGHKCKSKYDFACH 411

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Medaka
Match: IKZF5 (IKAROS family zinc finger 5 [Source:NCBI gene;Acc:101163616])

HSP 1 Score: 60.4622 bits (145), Expect = 2.179e-9
Identity = 22/47 (46.81%), Postives = 31/47 (65.96%), Query Frame = 2

Query: 1532 HKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            +KC HC++ F D   Y +HMG H  ++P+QCN CG  C+D +DF  H
Sbjct:  357 YKCQHCEVYFSDNILYTIHMGCHGYDHPFQCNNCGHMCTDKYDFACH 403

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Medaka
Match: ikzf1 (IKAROS family zinc finger 1 [Source:NCBI gene;Acc:100125523])

HSP 1 Score: 60.4622 bits (145), Expect = 2.912e-9
Identity = 27/80 (33.75%), Postives = 44/80 (55.00%), Query Frame = 2

Query: 1436 QKSQSDVM-ANGEGSPNLLKECVDNDIQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            Q+ Q D + AN E +    K    +  Q   + ++C HC++LF D   Y +HMG H   +P +CN+CG +  D ++F+ H
Sbjct:  453 QQRQYDALRANMEMASEGFKVVTSDGEQV--RAYRCEHCRVLFLDHVMYTIHMGCHGFRDPLECNLCGHRSQDRYEFSSH 530

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Medaka
Match: ikzf1 (IKAROS family zinc finger 1 [Source:NCBI gene;Acc:100125523])

HSP 1 Score: 60.4622 bits (145), Expect = 4.015e-9
Identity = 25/83 (30.12%), Postives = 45/83 (54.22%), Query Frame = 2

Query: 1424 EDKHQKSQSDVMANGEGSPNLLKECVDNDIQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            +++ Q+    + AN E +    K    +  Q   + ++C HC++LF D   Y +HMG H   +P +CN+CG +  D ++F+ H
Sbjct:  540 KEEQQRQYDALRANMEMASEGFKVVTSDGEQV--RAYRCEHCRVLFLDHVMYTIHMGCHGFRDPLECNLCGHRSQDRYEFSSH 620

[Close]

BLAST of C2H2-type domain-containing protein vs. Ensembl Medaka
Match: ikzf1 (IKAROS family zinc finger 1 [Source:NCBI gene;Acc:100125523])

HSP 1 Score: 60.077 bits (144), Expect = 4.799e-9
Identity = 25/83 (30.12%), Postives = 45/83 (54.22%), Query Frame = 2

Query: 1424 EDKHQKSQSDVMANGEGSPNLLKECVDNDIQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVH 1672
            +++ Q+    + AN E +    K    +  Q   + ++C HC++LF D   Y +HMG H   +P +CN+CG +  D ++F+ H
Sbjct:  495 KEEQQRQYDALRANMEMASEGFKVVTSDGEQV--RAYRCEHCRVLFLDHVMYTIHMGCHGFRDPLECNLCGHRSQDRYEFSSH 575

[Close]

BLAST of C2H2-type domain-containing protein vs. Planmine SMEST
Match: SMESG000014973.1 (SMESG000014973.1)

HSP 1 Score: 848.195 bits (2190), Expect = 0.000e+0
Identity = 428/428 (100.00%), Postives = 428/428 (100.00%), Query Frame = 2

Query:  401 MDINSDENQDSTQIGEINPVNLVTRIKHEAEEPSTNLKNFTEISDFVNCFXXXXXXXXXYVPYSLSSDQSRIPFNPSNNGVDNNKKIDCFYPSSSTNFKHFSCPNCKLQFANRDSLAMHMMESVRLDGCQTHKTSKNKPSPTLPMLEPTNVNRSQFSTDYDNNCRDKIVSSSANGTNTFSDISRERIQAPCFICKICGETFINLDSLAMHMFIHVQQETNPNKEVPGHQKSTHPXXXXXXPILSTNSVMPLPESIWSNHLNSSLYFKSLLTTSLIDPNKLQLELSRASDLFTTGKIQSLTKFNSTISNNTEDEILERKCRSAPLYNTNLDEKSVSSLNNDSEDKHQKSQSDVMANGEGSPNLLKECVDNDIQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVHSLHF 1684
            MDINSDENQDSTQIGEINPVNLVTRIKHEAEEPSTNLKNFTEISDFVNCFRRRRRGRSRYVPYSLSSDQSRIPFNPSNNGVDNNKKIDCFYPSSSTNFKHFSCPNCKLQFANRDSLAMHMMESVRLDGCQTHKTSKNKPSPTLPMLEPTNVNRSQFSTDYDNNCRDKIVSSSANGTNTFSDISRERIQAPCFICKICGETFINLDSLAMHMFIHVQQETNPNKEVPGHQKSTHPQQQQQQPILSTNSVMPLPESIWSNHLNSSLYFKSLLTTSLIDPNKLQLELSRASDLFTTGKIQSLTKFNSTISNNTEDEILERKCRSAPLYNTNLDEKSVSSLNNDSEDKHQKSQSDVMANGEGSPNLLKECVDNDIQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVHSLHF
Sbjct:    1 MDINSDENQDSTQIGEINPVNLVTRIKHEAEEPSTNLKNFTEISDFVNCFRRRRRGRSRYVPYSLSSDQSRIPFNPSNNGVDNNKKIDCFYPSSSTNFKHFSCPNCKLQFANRDSLAMHMMESVRLDGCQTHKTSKNKPSPTLPMLEPTNVNRSQFSTDYDNNCRDKIVSSSANGTNTFSDISRERIQAPCFICKICGETFINLDSLAMHMFIHVQQETNPNKEVPGHQKSTHPQQQQQQPILSTNSVMPLPESIWSNHLNSSLYFKSLLTTSLIDPNKLQLELSRASDLFTTGKIQSLTKFNSTISNNTEDEILERKCRSAPLYNTNLDEKSVSSLNNDSEDKHQKSQSDVMANGEGSPNLLKECVDNDIQFLSKLHKCNHCKILFEDATTYCLHMGLHNVNNPWQCNMCGKKCSDLHDFTVHSLHF 428

The following BLAST results are available for this feature:

BLAST of C2H2-type domain-containing protein vs. Ensembl Human
BLAST of C2H2-type domain-containing protein vs. Ensembl Celegans
BLAST of C2H2-type domain-containing protein vs. Ensembl Fly
BLAST of C2H2-type domain-containing protein vs. Ensembl Zebrafish
BLAST of C2H2-type domain-containing protein vs. Ensembl Xenopus
BLAST of C2H2-type domain-containing protein vs. Ensembl Mouse
BLAST of C2H2-type domain-containing protein vs. UniProt/SwissProt
BLAST of C2H2-type domain-containing protein vs. TrEMBL
BLAST of C2H2-type domain-containing protein vs. Ensembl Cavefish
BLAST of C2H2-type domain-containing protein vs. Ensembl Sea Lamprey
BLAST of C2H2-type domain-containing protein vs. Ensembl Yeast
BLAST of C2H2-type domain-containing protein vs. Ensembl Nematostella
BLAST of C2H2-type domain-containing protein vs. Ensembl Medaka
BLAST of C2H2-type domain-containing protein vs. Planmine SMEST

BLAST of C2H2-type domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
IKZF1	1.385e-10	44.90	IKAROS family zinc finger 1 [Source:HGNC Symbol;Ac...	[more]
IKZF1	1.843e-10	44.90	IKAROS family zinc finger 1 [Source:HGNC Symbol;Ac...	[more]
IKZF1	1.863e-10	44.90	IKAROS family zinc finger 1 [Source:HGNC Symbol;Ac...	[more]
IKZF1	3.444e-10	32.50	IKAROS family zinc finger 1 [Source:HGNC Symbol;Ac...	[more]
IKZF1	4.275e-10	44.90	IKAROS family zinc finger 1 [Source:HGNC Symbol;Ac...	[more]

BLAST of C2H2-type domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4


Match Name	E-value	Identity	Description
ehn-3	6.787e-7	39.58	Enhancer of HAND mutation hnd-1 [Source:UniProtKB...	[more]
ehn-3	9.603e-7	42.22	Enhancer of HAND mutation hnd-1 [Source:UniProtKB...	[more]
ehn-3	1.377e-6	39.58	Enhancer of HAND mutation hnd-1 [Source:UniProtKB...	[more]
ztf-16	1.472e-6	39.58	Zinc finger putative Transcription Factor family ...	[more]

BLAST of C2H2-type domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hb	7.561e-8	41.67	gene:FBgn0001180 transcript:FBtr0081951	[more]
hb	7.561e-8	41.67	gene:FBgn0001180 transcript:FBtr0081950	[more]
CG12769	3.789e-7	41.67	gene:FBgn0033252 transcript:FBtr0088827	[more]
CG12769	3.931e-7	41.67	gene:FBgn0033252 transcript:FBtr0088828	[more]
CG12769	3.980e-7	41.67	gene:FBgn0033252 transcript:FBtr0339281	[more]

BLAST of C2H2-type domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ikzf5	1.668e-10	46.30	IKAROS family zinc finger 5 [Source:NCBI gene;Acc:...	[more]
ikzf5	1.668e-10	46.30	IKAROS family zinc finger 5 [Source:NCBI gene;Acc:...	[more]
ikzf5	1.668e-10	46.30	IKAROS family zinc finger 5 [Source:NCBI gene;Acc:...	[more]
ikzf5	1.668e-10	46.30	IKAROS family zinc finger 5 [Source:NCBI gene;Acc:...	[more]
ikzf5	1.668e-10	46.30	IKAROS family zinc finger 5 [Source:NCBI gene;Acc:...	[more]

BLAST of C2H2-type domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
six3	2.672e-10	44.90	SIX homeobox 3 [Source:Xenbase;Acc:XB-GENE-478761]	[more]
six3	3.848e-10	44.90	SIX homeobox 3 [Source:Xenbase;Acc:XB-GENE-478761]	[more]
ikzf5	8.214e-10	50.00	IKAROS family zinc finger 5 [Source:NCBI gene;Acc:...	[more]
ikzf5	8.333e-10	50.00	IKAROS family zinc finger 5 [Source:NCBI gene;Acc:...	[more]
TRPS1	7.509e-9	43.21	transcriptional repressor GATA binding 1 [Source:N...	[more]

BLAST of C2H2-type domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Ikzf5	3.785e-11	46.30	IKAROS family zinc finger 5 [Source:MGI Symbol;Acc...	[more]
Ikzf5	1.509e-10	46.30	IKAROS family zinc finger 5 [Source:MGI Symbol;Acc...	[more]
Ikzf1	5.986e-10	44.90	IKAROS family zinc finger 1 [Source:MGI Symbol;Acc...	[more]
Ikzf1	7.910e-10	44.90	IKAROS family zinc finger 1 [Source:MGI Symbol;Acc...	[more]
Ikzf1	8.349e-10	44.90	IKAROS family zinc finger 1 [Source:MGI Symbol;Acc...	[more]

BLAST of C2H2-type domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q8BU00\|IKZF5_MOUSE	1.056e-9	46.30	Zinc finger protein Pegasus OS=Mus musculus OX=100...	[more]
sp\|Q6DBW0\|IKZF5_DANRE	1.259e-9	46.30	Zinc finger protein Pegasus OS=Danio rerio OX=7955...	[more]
sp\|Q5ZLR2\|IKZF5_CHICK	2.096e-9	50.00	Zinc finger protein Pegasus OS=Gallus gallus OX=90...	[more]
sp\|O42410\|IKZF1_CHICK	2.119e-9	36.59	DNA-binding protein Ikaros OS=Gallus gallus OX=903...	[more]
sp\|Q6NRM0\|IKZF5_XENLA	2.632e-9	46.30	Zinc finger protein Pegasus OS=Xenopus laevis OX=8...	[more]

BLAST of C2H2-type domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1S3KDL6	4.609e-15	26.79	zinc finger protein 423 OS=Lingula unguis OX=7574 ...	[more]
A0A0L8I0P1	2.689e-13	63.27	Uncharacterized protein OS=Octopus bimaculoides OX...	[more]
K1QP68	3.916e-13	58.82	C2H2-type domain-containing protein OS=Crassostrea...	[more]
V4AEJ5	1.685e-12	48.61	C2H2-type domain-containing protein OS=Lottia giga...	[more]
T1G783	1.685e-12	57.14	C2H2-type domain-containing protein OS=Helobdella ...	[more]

BLAST of C2H2-type domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ikzf1	2.647e-9	38.78	IKAROS family zinc finger 1 (Ikaros) [Source:ZFIN;...	[more]
ikzf1	2.849e-9	38.78	IKAROS family zinc finger 1 (Ikaros) [Source:ZFIN;...	[more]
IKZF5	2.998e-9	45.83	zinc finger protein Pegasus-like [Source:NCBI gene...	[more]
ikzf5	7.006e-9	45.83	zinc finger protein Pegasus [Source:NCBI gene;Acc:...	[more]
ikzf1	7.384e-9	38.78	IKAROS family zinc finger 1 (Ikaros) [Source:ZFIN;...	[more]

BLAST of C2H2-type domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000000869.1	5.759e-11	42.86	pep scaffold:Pmarinus_7.0:GL476362:938611:940054:-...	[more]
ENSPMAT00000000367.1	5.811e-11	48.00	pep scaffold:Pmarinus_7.0:GL480594:46543:47925:-1 ...	[more]
ENSPMAT00000005061.1	1.130e-9	46.81	pep scaffold:Pmarinus_7.0:GL476392:809231:810583:1...	[more]
ikzf4	2.124e-9	27.84	IKAROS family zinc finger 4 [Source:ZFIN;Acc:ZDB-G...	[more]
ikzf4	2.167e-9	27.84	IKAROS family zinc finger 4 [Source:ZFIN;Acc:ZDB-G...	[more]

BLAST of C2H2-type domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of C2H2-type domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of C2H2-type domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ikzf5	1.438e-10	52.08	zinc finger protein Pegasus [Source:NCBI gene;Acc:...	[more]
IKZF5	2.179e-9	46.81	IKAROS family zinc finger 5 [Source:NCBI gene;Acc:...	[more]
ikzf1	2.912e-9	33.75	IKAROS family zinc finger 1 [Source:NCBI gene;Acc:...	[more]
ikzf1	4.015e-9	30.12	IKAROS family zinc finger 1 [Source:NCBI gene;Acc:...	[more]
ikzf1	4.799e-9	30.12	IKAROS family zinc finger 1 [Source:NCBI gene;Acc:...	[more]

BLAST of C2H2-type domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000014973.1	0.000e+0	100.00	SMESG000014973.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30024902 ID=SMED30024902|Name=C2H2-type domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1835bp
GGGGTGTGTGCTGTCTTTGAGTAGGGCCCCTACACCAGCCAGTGTTTGGA
ATTCGTGAATAATTTATTCATTCGTGTTTGAAGGATAGTTTGAAAGCAAG
CAGACATAGCCGATGTCAGTTTCATGTTGACGCATACATTTTAGATGAAG
AAAGAAATAATAGGACGATTACGATTGGCTGTTGGATGATACACACATTT
TATCGAGTAAAAATTGTGTGTGTGTGCGAACTTATTTACAACTCGATGCA
TTGAGTATAATTAGAGTAACTGCTTACATTAGATATATGCTTGGTCGATA
ATTCGTTAATTTTTTTCAAAACTGTTTTCTGGATATTCGGCGAACAACGG
ATTAAACGAAACAAAACAAAACGATTAATCAACAAATATTAATTAAATTT
ATGGATATTAATTCTGATGAAAATCAAGATTCAACGCAGATAGGAGAGAT
CAATCCCGTAAACCTTGTCACCAGAATCAAGCATGAAGCCGAAGAACCTT
CGACAAATCTTAAAAATTTCACTGAAATTTCAGATTTCGTCAATTGTTTT
CGAAGGCGACGTCGAGGTCGAAGTCGCTATGTTCCATATAGTCTGTCAAG
TGACCAATCTCGAATCCCATTCAATCCATCCAACAATGGCGTTGATAATA
ATAAAAAAATCGACTGTTTTTATCCGAGTTCCTCTACAAATTTTAAACAT
TTTTCCTGTCCGAATTGTAAATTACAATTCGCAAATCGCGACTCGCTAGC
AATGCACATGATGGAGAGTGTCAGGCTCGACGGATGTCAAACTCACAAAA
CCTCTAAAAACAAACCAAGTCCCACTTTGCCAATGCTTGAGCCAACTAAC
GTAAACAGATCTCAATTTTCCACAGATTACGACAATAACTGTCGGGATAA
AATTGTTTCGTCGTCAGCAAATGGAACGAATACGTTCTCAGATATCAGCC
GGGAAAGAATTCAAGCTCCATGCTTCATTTGTAAAATATGTGGCGAGACC
TTCATCAATTTAGATTCACTGGCCATGCACATGTTTATTCATGTTCAACA
AGAAACAAACCCAAACAAAGAGGTTCCTGGCCATCAAAAATCAACTCACC
CCCAACAACAACAACAACAGCCAATTTTATCAACCAACTCGGTAATGCCC
TTACCAGAGTCCATATGGAGCAATCACCTCAACTCGTCTCTCTATTTCAA
AAGTCTATTAACCACATCCTTAATCGACCCTAACAAACTCCAACTCGAGT
TATCTAGAGCATCAGATCTTTTTACGACTGGTAAAATCCAGTCATTGACC
AAATTCAACTCTACCATATCTAACAATACAGAAGATGAAATTTTGGAAAG
AAAATGCCGTTCAGCTCCTCTTTACAACACAAACCTAGATGAAAAATCCG
TGTCAAGTTTAAACAACGACTCAGAAGACAAGCACCAAAAGTCACAGAGT
GACGTAATGGCAAATGGTGAAGGGAGCCCAAATTTGTTGAAAGAGTGCGT
AGATAATGACATCCAATTCCTGTCGAAACTTCACAAATGCAATCATTGCA
AAATCCTTTTTGAAGATGCCACGACCTACTGCCTTCACATGGGGCTGCAT
AACGTCAACAATCCTTGGCAGTGCAACATGTGCGGCAAGAAGTGTTCCGA
CCTTCACGATTTCACGGTCCACTCTCTCCATTTCTGAGTCCCCAATCGGT
GTTACGCACCAGACCAACTTAGAGGATTATGAAGACTTGCAAATATCTAT
TTCTCCTAATGACATTTTTAAATGAATCATGAAAATTTTGAAAATTTCTG
TAATAATACATATTTCGTTTTGCACTTTCTAGCCC

protein sequence of SMED30024902-orf-1

>SMED30024902-orf-1 ID=SMED30024902-orf-1|Name=SMED30024902-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=429bp
MDINSDENQDSTQIGEINPVNLVTRIKHEAEEPSTNLKNFTEISDFVNCF
RRRRRGRSRYVPYSLSSDQSRIPFNPSNNGVDNNKKIDCFYPSSSTNFKH
FSCPNCKLQFANRDSLAMHMMESVRLDGCQTHKTSKNKPSPTLPMLEPTN
VNRSQFSTDYDNNCRDKIVSSSANGTNTFSDISRERIQAPCFICKICGET
FINLDSLAMHMFIHVQQETNPNKEVPGHQKSTHPQQQQQQPILSTNSVMP
LPESIWSNHLNSSLYFKSLLTTSLIDPNKLQLELSRASDLFTTGKIQSLT
KFNSTISNNTEDEILERKCRSAPLYNTNLDEKSVSSLNNDSEDKHQKSQS
DVMANGEGSPNLLKECVDNDIQFLSKLHKCNHCKILFEDATTYCLHMGLH
NVNNPWQCNMCGKKCSDLHDFTVHSLHF*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000035	Category 3 cell
PLANA:0000099	neuron
PLANA:0000418	head
PLANA:0002109	X1 cell
PLANA:0002111	X2 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036236	Znf_C2H2_sf
IPR015880	Znf_C2H2-like
IPR013087	Znf_C2H2_type
IPR007087	Znf_C2H2

Vocabulary: **molecular function**
Term	Definition
GO:0003676	nucleic acid binding
GO:0046872	metal ion binding
GO:0003677	DNA binding

Vocabulary: **cellular component**
Term	Definition
GO:0005622	intracellular
GO:0005634	nucleus

Vocabulary: **biological process**
Term	Definition
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR013087	Zinc finger C2H2-type	SMART	SM00355	c2h2final6	coord: 378..400 e-value: 4.8 score: 16.1 coord: 192..214 e-value: 0.0012 score: 28.1 coord: 406..427 e-value: 13.0 score: 12.3 coord: 101..121 e-value: 13.0 score: 12.2
IPR013087	Zinc finger C2H2-type	PFAM	PF00096	zf-C2H2	coord: 192..214 e-value: 0.0011 score: 19.2
IPR013087	Zinc finger C2H2-type	PROSITE	PS00028	ZINC_FINGER_C2H2_1	coord: 194..214
IPR013087	Zinc finger C2H2-type	PROSITE	PS00028	ZINC_FINGER_C2H2_1	coord: 380..400
IPR013087	Zinc finger C2H2-type	PROSITE	PS50157	ZINC_FINGER_C2H2_2	coord: 378..405 score: 8.538
IPR013087	Zinc finger C2H2-type	PROSITE	PS50157	ZINC_FINGER_C2H2_2	coord: 192..219 score: 11.011
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 336..350
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 330..354
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 222..241
None	No IPR available	PANTHER	PTHR24404	ZINC FINGER PROTEIN	coord: 38..424
IPR036236	Zinc finger C2H2 superfamily	SUPERFAMILY	SSF57667	beta-beta-alpha zinc fingers	coord: 376..425
IPR036236	Zinc finger C2H2 superfamily	SUPERFAMILY	SSF57667	beta-beta-alpha zinc fingers	coord: 191..218

Main menu

C2H2-type domain-containing protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 8

Owlery

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