death domain-containing protein 1

Overview
Namedeath domain-containing protein 1
Smed IDSMED30024895
Length (bp)2600
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of death domain-containing protein 1 (SMED30024895) t-SNE clustered cells

Violin plots show distribution of expression levels for death domain-containing protein 1 (SMED30024895) in cells (dots) of each of the 12 neoblast clusters.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30024895

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30024895h1SMcG0005925 dd_Smed_v4_79849_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30024895h1SMcG0005925 dd_Smed_v4_79849_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30024895h1SMcG0005925 dd_Smed_v4_79849_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
reproductive organSMED30024895h1SMcG0005925 Contig9987newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30024895h1SMcG0005925 Contig9987uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30024895h1SMcG0005925 Contig17639newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30024895h1SMcG0005925 Contig17639uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of death domain-containing protein 1 vs. TrEMBL
Match: K1S6Z0 (Uncharacterized protein OS=Crassostrea gigas OX=29159 GN=CGI_10027320 PE=4 SV=1)

HSP 1 Score: 136.732 bits (343), Expect = 1.545e-43
Identity = 122/461 (26.46%), Postives = 223/461 (48.37%), Query Frame = 1 
Query:  571 NFRYWPTYIYWVKPENSYSKKMGCILKAKPGGIGRHTNFECSSIYSSRILPNIDLQEDAASIPIEIKPTDPSQEFNFENPWKLILPHILPKNSP-KDPVILMLSDDDTG-WIEMPTSEIILDDLKEHKLRFVETKLEKRSGIFIVQTKNRTDNGIINKHGARIASSMDSRVFVSVPAGAIRITLNTTLKINTVDSSFWKELKGKFDKSPLE--QVICSSHLIAFTSKKKKLIKPAIISCHLPLNA-EVKKQQEVQPXXXXXXXXXXXXXXXXXXXXXXXXSFIPKIEMNAFQKSLLMSGISGA--NANESIKVLVYSNEEDK--WNEMEKPEISTDKTKEQMSLEFPTIQSTKFFMLRANRTITFENLTKGVKLIETEFSLRNSLIILLKSAKNPYEFILLTCLKSRSEKIISQFKDDGYNVEPQNTPVS--IELKERQILRTSFSGNIQNVNPDKNTMFF 1920
            N + WP YIY V      +   GC+++A  G + R      +    S +L  ++ +E  ++I + I P+DP ++F FE P  + +PH L +N P ++PVI  L    TG W E+PT++I+++D++E  ++FVE ++ KR G+F +  + + D     + G ++ SS+D+R+  +   G ++  +  T ++  +D +   EL  ++   P E   ++ SS ++ F    +K  KP   +  LP N+ ++K+ Q V P +  K K    +                     A  + L   G S       E + +LV    EDK  W      E+   K K+ ++ +       +F +LR  + I+  ++ K    +E     R   ++L + + +P E +++ C  SR++K I    ++G++  P   P S  I +KE QIL   F GNI+  + +K ++ F
Sbjct:  835 NPKNWPRYIYSVDSSTIEAGVPGCVIRAIEGSMKRDDVTVKAVDQLSGVLTLVENEELVSNI-VSITPSDPERKFQFEEPVSVAIPHCLQRNIPGREPVIKQLQP--TGKWAELPTNDIVIEDMRE--MKFVEIRV-KRFGVFAIVLRIKKDTLTFLRRGNKVNSSVDARISFTCKPGMVKNNVCFTSEVQALDVNTVTELNKRY---PTECGSLLSSSPIVRFQIPNRKFAKPLTFTLPLPPNSTKLKRPQSVAPGSLNKDKGEHRE--------------------QAAARPLSSIGFSTKEDEPEEEMHLLVR---EDKGPWTIQPNVELFQPKNKDIVTFDIKEPHD-RFIILRTKQGISPLSVEKMASHVERAIHHRTMQVVLRQRSDDPNEVVIVCCPASRTDKTIKILGEEGFDEGP---PPSKDIIVKEGQILDIMFRGNIRCDDAEKISIVF 1259

HSP 2 Score: 71.2478 bits (173), Expect = 1.545e-43
Identity = 53/168 (31.55%), Postives = 88/168 (52.38%), Query Frame = 3 
Query: 1959 YAQRAIDHYRGYIMVFTKKLMKKPIESADK-KARKGHVQYQMVEEDFMICQLLISIPKKGLIAHKPLRNIPF-------NREILEDFLCMFTRIADGIGISWKELGTSLKISESRLQ-MLKHHNPGNQPGKIVIQMLLFWFKGLELMDDKTEMLRQSLLEVNRNDLAV 2435
            +AQ++   YRG+  V+T   +++P+   DK KA +     ++VEE+ ++ +LLI+IPK      KPL   P        N+E +  +      +A  +G  WK+L   L +   R+Q +L+ +N   +P KI   ML+ W K +    +K E+L Q+L    R DLA+
Sbjct: 1277 FAQKSFSFYRGFAQVYTTVHVQRPVVGTDKTKAPQKPGAMEVVEENVLLTELLINIPKPEPEPPKPLATAPIKVTAEGPNKEDILQY------VASELGDEWKKLAQYLSLKSVRIQAILRQNNQNPEPKKIRYDMLVTWAKRVPRCLNKLEILAQALSACGRGDLAI 1438
[Close]
BLAST of death domain-containing protein 1 vs. TrEMBL
Match: A0A210QUR4 (Death domain-containing protein 1 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT06862 PE=4 SV=1)

HSP 1 Score: 114.39 bits (285), Expect = 2.947e-38
Identity = 98/441 (22.22%), Postives = 196/441 (44.44%), Query Frame = 1 
Query:  571 NFRYWPTYIYWVKPENSYSKKMGCILKAKPGGIGRHTNFECSSIYSSRILPNIDLQEDAASIPIEIKPTDPSQEFNFENPWKLILPHILPKNSPKDPVILMLSDDDTGWIEMPTSEIILDDLKEHKLRFVETKLEKRSGIFIVQTKNRTDNGIINKHGARIASSMDSRVFVSVPAGAIRITLNTTLKINTVDSSFWKELKGKFDKSPLE--QVICSSHLIAFTSKKKKLIKPAIISCHLPLNAEVKKQQEVQPXXXXXXXXXXXXXXXXXXXXXXXXSFIPKIEMNAFQKSLLMSGISGANANESIKVLVYSNEEDKWNEMEKPEISTDKTKEQMSLEFPTIQSTKFFMLRANRTITFENLTKGVKLIETEFSLRNSLIILLKSAKNPYEFILLTCLKSRSEKIISQFKDDGYNVEPQNTPVSIELKERQILRTSFSGNIQ 1887
            N + W   +Y       +   +GCIL+A    +GR           S +L  +D +E  ++I I+I PTD  + F FE P  L +PH LP+      V++     +  W+E+PT + + +D+KE  +RF E +  +R G+F V  + + D     + G ++ +++D+RV  + P G  +   N T+++  +D +    LK K    P+E   ++  S ++ F+ + +K  K   ++  +P N          P    +          +D  +++  +  P +  NA ++  +   +           L+   E   W ++    I   K K+ +++E       +F ++R    +    L     L++   + R+  + L +   N  +  + +   S++EK + +   +GY+  P  +   I +KE Q++R +F GN+ 
Sbjct:  925 NPKNWRRLVYSADG-GDFDPGVGCILRAIDNCLGRDDVNVVRVDQMSGVLTLVDNEELISNI-IKITPTDAERRFTFEEPVALAIPHCLPRAVAGREVVVKTRSANGKWVELPTKDAVFEDMKE--MRFGEAQT-RRFGVFAVVLRLKKDTLTFVRKGNKVHTAVDARVSFTSPPGMFKTNTNFTVEVQQIDQTAIASLKHKH---PVECGNLMACSPIMKFSIQNRKFNKTLTMTLPIPQN----------PTRPKRPSTAVASAPKEDKSEQRPVTARPLVSFNANKEEEIEEELH----------LLVCEEGCLWTKLADVSIVQAKNKDIVTVEVKEPHD-RFLVIRTGLGVGPAKLETAATLLDRSVTQRSINVFLRQLNTNLNQVAVGSSKISKTEKELKKLAAEGYDDGPAPSR-EIVVKEGQMIRLAFRGNVH 1335

HSP 2 Score: 75.8702 bits (185), Expect = 2.947e-38
Identity = 56/166 (33.73%), Postives = 88/166 (53.01%), Query Frame = 3 
Query: 1959 YAQRAIDHYRGYIMVFTKKLMKKPIESADKKARKGHVQYQMVEEDFMICQLLISIPKKGLIAHKPLRNIPF--NREILEDFLCMFTRIADGIGISWKELGTSLKISESRLQ-MLKHHNPGNQPGKIVIQMLLFWFKGLELMDDKTEMLRQSLLEVNRNDLAVMMRE 2447
            +AQ+  + YRG+  ++T  L+ KP+   DK  +K  V  +M+EE+ ++ +LL+SIPK      KPL   P   N E   D   +   +A  +G  WK+L   L +   R+Q +L+ +N    P KI   ML+ W K +    +K ++L  +LL   R DLA  +RE
Sbjct: 1365 FAQKGFNCYRGFSQIYTNVLVPKPVPPTDKPKQKQTVA-EMIEEEKLVAELLMSIPKPEPEPPKPLCTAPIKINAE-GPDTQDVLMYLAGELGEEWKKLAQYLNLKSVRIQAILRQNNMNPDPKKIRYDMLVTWAKRIPRSANKMDILAHALLASGRGDLAEELRE 1528
[Close]
BLAST of death domain-containing protein 1 vs. TrEMBL
Match: V3ZPR4 (Uncharacterized protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_232757 PE=4 SV=1)

HSP 1 Score: 119.013 bits (297), Expect = 6.527e-38
Identity = 117/473 (24.74%), Postives = 219/473 (46.30%), Query Frame = 1 
Query:  562 DPNNFRYWPTYIYWVKPENSYSKKMGCILKAKPGGIGRHTNFECSSIYSSRILPNIDLQEDA---ASIPIEIKPTDPSQEFNFENPWKLILPHILPKNSP-KDPVILMLSDDDTGWIEMPTSEIILDDLKEHKLRFVETKLEKRSGIFIVQTKNRTDNGIINKHGARIASSMDSRVFVSVPAGAIRITLNTTLKINTVDSSFWKELKGKFDKSPLEQVICSSHLIAFTSKKK-KLIKPAIISCHLPLN-AEVKK-----------QQEVQPXXXXXXXXXXXXXXXXXXXXXXXXSFIPKIEMNAFQKSLLMSGISGANANESIKVLVYSNEEDKWNEMEKPEISTDKTKEQMSLEFPTIQSTKFFMLRANRTITFENLTKGVKLIETEFSLRNSLIILLKSAKNPYEFILLTCLKS-RSEKIISQFKDDGYNVEPQNTPVS--IELKERQILRTSFSGNIQNVNPDKNTMFF 1920
            +PNN   WP YIY ++ E+ ++  +GCI+++  G + R  + E + I   +I     + E+    ++I +  + TD + EF  E P  +++PH  P+++  ++PV+    D    W+E+ T++++ DD+K+  LRFVE ++ K  G F+V  + + +     K G + +S++DSR  ++   GA R  L  + +I  VDS+   EL+ + D      ++ S+ +I  T K+  +L KP  I+   P N A +K+           +Q+ +P                                 A   S        A   E + +++  N    W  +    I+  K K+ +SL+  T   T+F +LR    +      K V  +E    L+ ++ + L+        IL++C  + + EK++ +  ++GY+  P   P+S  I ++E Q+L   F GN+  V   +  + F
Sbjct:  715 NPNN---WPRYIYSIESED-FNPGIGCIIRSIKGSLDRD-DIEVNRI--DQITGGYQIHENEELISNIIVVKQMTDKNLEF--EEPLSIVMPHCAPRSTTGREPVMKCYDDTAANWVELQTNDVMFDDIKD--LRFVEARVTKL-GKFVVVYRLKKEQFTFTKKGGKQSSTVDSRFTLTTKPGAFRYNLGVSTEIQPVDSNTVSELRQR-DNEICGALLASTSIITMTWKQNTRLSKPITITLPCPPNPARIKRPSTAVNREKVAKQDARP-------------------------------QTARPASEYFKHTDDAKLEEELHLVIKDNTS-GWLTVPDVVITQAKNKDIISLDI-TEPITRFVVLRTKMDLAEYQAEKMVSRLEKAL-LQRTIQLFLRQNTEDLNEILVSCANTNKIEKVLKRLDEEGYDEGP---PLSKDIIVREGQVLELRFRGNLAPVTEHRTKIAF 1137

HSP 2 Score: 70.0922 bits (170), Expect = 6.527e-38
Identity = 53/173 (30.64%), Postives = 87/173 (50.29%), Query Frame = 3 
Query: 1959 YAQRAIDHYRGYIMVFTKKLMKKPI-ESADKKARKG-----HVQYQMVEEDFMICQLLISIPKKGLIAHKPLRNIPFNRE----ILEDFLCMFTRIADGIGISWKELGTSLKISESRLQMLKHHNPGNQPGKIVIQMLLFWFKGLELMDDKTEMLRQSLLEVNRNDLAVMMRE 2447
            +AQR  D YRG+  VFT  L+ K I E  ++   KG     +   +MVE + ++ +LL++IPK      +PL   P + +    + ED   +F  I+  +G  W++L   L +   R+Q +   N  ++  + +  ML+ W K +    DK EML  +L    R DL  ++RE
Sbjct: 1155 FAQRGFDSYRGFCQVFTDGLVPKVIQEQEERDTGKGRNNPKNTHVEMVEGEILLGELLMNIPKPEPEPPRPLVKAPVSIKPEGPVNED---VFRFISREVGDEWRKLAQYLNVRRMRIQAILRQNVNSERQQTIYDMLVSWAKRVPRAMDKVEMLCHALSVCGRGDLVEILRE 1324
[Close]
BLAST of death domain-containing protein 1 vs. TrEMBL
Match: A0A1S3HDZ3 (death domain-containing protein 1 OS=Lingula unguis OX=7574 GN=LOC106153746 PE=4 SV=1)

HSP 1 Score: 106.301 bits (264), Expect = 1.141e-34
Identity = 113/449 (25.17%), Postives = 187/449 (41.65%), Query Frame = 1 
Query:  562 DPNNFRYWPTYIYWVKPEN-SYSKKMGCILKAKPGGIG--RHTNFECSSIYSSRILPNIDLQEDAASIPIEIKPTDPSQEFNFENPWKLILPHILPKNSPKDPVILMLSDDDTGWIEMPTSEIILDDLKEHKLRFVETKLEKRSGIFIVQTKNRTDNGIINKHGARIASSMDSRVFVSVPAGAIRITLNTTLKINTVDSSFWKELKGKF--DKSPLEQVICSSHLIAFTSKKKKLIKPAIISCHLPLNAEVKKQQEVQPXXXXXXXXXXXXXXXXXXXXXXXXSFIPKIEMNAFQKSLLMSGISGANANESIKVLVYSNEEDKWNEMEKPEISTDKTKEQMSLEFPTIQSTKFFMLRANRTITFENLTKGVKLIETEFSLRNSLIILLKSAKNPYEFILLTCLKSRSEKIISQFKDDGYNVEPQNTPVS--IELKERQILRTSFSGNIQ 1887
            DPNN   WP + Y    E   +   +  ++++ P  +      + +C  +        I   E+  S  +EI P+     F FE P  + +PH   K S ++  +  L      W E+P+ EIIL DL+E K  FV+ +L K  G F V T+ + D  + NK   +++S++D R+ +    G +  T    L++  VDS    ELK +   D  PL   +  S ++ F     K  KP  ++   P N + K+ Q  +PK    K  R                       +AF   L        +  +++ +L  +  ++ W  M   +IS  K K+ +  E  T    +F  LR           K   LIET    R    +L + + +P +  L     ++ +K + +  ++G++  P   P S  + L E Q L   F GNIQ
Sbjct:  305 DPNN---WPLFTYRYNEEQIDFDLGIMAVVRSMPWTMDPDDEESLQCKKLNQLDSTLTIAENEELVSNIVEIVPSSEKVVFKFEEPLAVAIPHCAQKVSSRELAVKYLETGKDKWRELPSQEIILQDLREAK--FVQCRL-KTFGQFAVVTRLKLDRLVPNKKDGKMSSTVDQRLVLHCRPGTVPSTATFGLQVQPVDSFAISELKVRLSEDCGPL---LTCSPIVRFQCSTSKFKKPIQVTIPCPPNPKAKRPQTARPKEKEGKSTRPS---------------------SAFSLGLKQKA-EDDDLEDTVFLLTRTEGDEGWIVMADIDISESKKKDAVIFEI-TKPYDRFMALRLKHGAGGMKAQKLANLIETALQKRTVRAVLRQKSDDPSDVSLQCLAANKIDKALRKMTEEGFDDGP---PASKDLVLTEGQELFLRFRGNIQ 718

HSP 2 Score: 72.0182 bits (175), Expect = 1.141e-34
Identity = 54/175 (30.86%), Postives = 92/175 (52.57%), Query Frame = 3 
Query: 1959 YAQRAIDHYRGYIMVFTKKLMKKPI--ESADKKARKGHV----QYQMVEEDFMICQLLISIPKKG------LIAHKPLRNIPFNREILEDFLCMFTRIADGIGISWKELGTSLKISESRLQMLKHHNPGNQPGKIVIQMLLFWFKGLELMDDKTEMLRQSLLEVNRNDLAVMMRE 2447
            +AQ+++D YRG++ V+TK ++K+ I  E+ D+ A  G      +   V  D ++C+LL+S+PK        L+   P+  IP +  + E  L     IA  +G  WK++   L I +SR+Q +  +N  +     +  ML+ W K +    DK E+L ++L    R DLA ++ E
Sbjct:  748 FAQKSLDCYRGFVQVYTKGMIKQIIKKENEDRDAVGGKSGPKEEVTWVMGDILLCELLVSLPKPEPEAPKPLVQKAPVTFIP-DGPVDESVL---RNIATDLGDEWKKVAHILNIRKSRVQAILRNNVNSDNEVAIYDMLITWAKKVPRSMDKVELLGKALTSAGRPDLAYIVYE 918
[Close]
BLAST of death domain-containing protein 1 vs. TrEMBL
Match: A0A158R6G9 (Death domain-containing protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS219 PE=4 SV=1)

HSP 1 Score: 93.5893 bits (231), Expect = 3.614e-30
Identity = 107/488 (21.93%), Postives = 202/488 (41.39%), Query Frame = 1 
Query:  583 WPTYIYWVKPENSYSKKMGCILKAKPGGIGRHTNFECSSIYSSRILPNIDLQEDAASIP--IEIKPTDPSQEFNFEN-PWKLILPHILPKNSPKDPVILMLSDDDTG----------------------WIEMPTSEIILDDLKEHKLRFVETKLEKRSGIFIV--QTKNRTDNGIINKHGARIASSMDSRVFVSVPAGAIRITLNTTLKINTVDSSFWKELKGKFDKSPLEQVICSSHLIAFTSKKKKLIKPAIISCHLPL-------------NAEV----------KKQQEVQPXXXXXXXXXXXXXXXXXXXXXXXXSFIPKIEMNAFQKSLLMSG-ISGANANESIKVLVYSNEEDK-WNEMEKPEISTDKTKEQMSLEFPTIQSTKFFMLRANRTITFENLTKGVKLIETEFSLRNSLIILLKSAKNPYEFILLTCLKSRSEKIISQFKDDGYNVEPQNTPVS-IELKERQILRTSFSGNIQ 1887
            W  Y+Y         +++ C ++A P  +       CS  Y++ +    DL  +A  I   + I+P  P       N PW + +PH   KN  ++ V+  +  +++G                      W+++ T+++  +D      R++E KL +      +    + R D G   + G ++ S +D RV +++P+GA++I    ++++  +       L+ + + S + Q    S L+  T  KK L K A+ +  LPL             NA +          K  ++   ++  +  +   D+E+  +         P+ E++ FQ+SLL+   ++GAN+  S   LVYS  ED  W      +    K  +  +  F  I   KF  ++    +  +NL +  +++E   S R     L ++ + P       CL    EK +SQ    G+       P+  + + ERQ    +  GNI+
Sbjct:  313 WIKYVYATG--EGAEQRVICYVRAPPDCLVSQDRLICS--YANALAQWPDLPGNAEVIGNFVCIRPRHPKLICILPNEPWIVGIPHKYGKNPTREVVVFTMEAEESGPERSRFRKVFDANEHPEPPHSLWVDLQTADMAYED-----SRYLEFKLSRLVAPIALAPAARIRRDIGEFGRGGGKLTSLVDKRVMLTLPSGALKIACTYSIQVQPISQHHAHLLRDQ-NLSFMSQFTACSPLVILTGPKKILFKAALFT--LPLTDTNPSNQVVIMSNASMPDAFLGHKKPKGHRDGNSESEAQDGENGADEEEAGSEQLSEGGNSPR-ELDPFQRSLLLPKLLAGANSGHSEVNLVYSGIEDSNWKIWGNVDFVETKNVDICTFSFNRIVPRKFMAIQTRTVVDNDNLIQMAQVLERSLSQRIVFACLRQNKQQPSRVCFAICLTQDLEKTLSQMAAKGFT--EGGKPIGPLFVYERQQFDVTLKGNIR 785

HSP 2 Score: 69.707 bits (169), Expect = 3.614e-30
Identity = 51/166 (30.72%), Postives = 88/166 (53.01%), Query Frame = 3 
Query: 1956 TYAQRAIDHYRGYIMVFTKKLMKKPIESADKKARK---GHVQYQMVEEDFMICQLLISIPKKGLIAH--KPLRNIPFNRE--ILEDFLCMFTRIADGIGISWKELGTSLKISESRLQMLKHHNPGNQPGKIVIQMLLFWFKGLELMDDKTEMLRQSLLEVNRNDLA 2432
            + AQ A + YRG+I +  K+L K  + +   K R    G  ++ M  E  ++CQLL+++PKK + A   K + +  F+ +  +  + L    R   G   +W+ LG +L +S ++LQ +      ++  +  + ML  W K LEL  D+ E LR +L+ + R+DLA
Sbjct:  826 SSAQVACEKYRGFIEISYKQLTK--VSAKRGKGRSNPMGPKKFAMELETVILCQLLVTLPKKAIEADVDKDILSYRFDSKDAVTNEMLQELARKLPGE--TWRRLGMALDLSRTQLQAIGGRADSSRKNR-ALTMLRSWIKNLELRVDRGEKLRAALIAIGRSDLA 986
[Close]
BLAST of death domain-containing protein 1 vs. Planmine SMEST
Match: SMESG000031073.1 (SMESG000031073.1)

HSP 1 Score: 1266.52 bits (3276), Expect = 0.000e+0
Identity = 650/651 (99.85%), Postives = 650/651 (99.85%), Query Frame = 1 
Query:    1 LESNHQEFIVKPEEKHEKDVSSKKSCCGRESTKVSKEVSQSDRKEVAEYDPKTNTESNIDFEKEEDNIPFDFDEENQSKSQIISNDWPPKPDSLLDEEYLKNQKSNKEYRESVKKTDLDVRTPDXXXXXXXXXXXXXQFELFEEHFTSSQETPDSTELANSYKDIEDEEDIQGNIHMTDEDFTIPLDDPNNFRYWPTYIYWVKPENSYSKKMGCILKAKPGGIGRHTNFECSSIYSSRILPNIDLQEDAASIPIEIKPTDPSQEFNFENPWKLILPHILPKNSPKDPVILMLSDDDTGWIEMPTSEIILDDLKEHKLRFVETKLEKRSGIFIVQTKNRTDNGIINKHGARIASSMDSRVFVSVPAGAIRITLNTTLKINTVDSSFWKELKGKFDKSPLEQVICSSHLIAFTSKKKKLIKPAIISCHLPLNAEVKKQQEVQPXXXXXXXXXXXXXXXXXXXXXXXXSFIPKIEMNAFQKSLLMSGISGANANESIKVLVYSNEEDKWNEMEKPEISTDKTKEQMSLEFPTIQSTKFFMLRANRTITFENLTKGVKLIETEFSLRNSLIILLKSAKNPYEFILLTCLKSRSEKIISQFKDDGYNVEPQNTPVSIELKERQILRTSFSGNIQNVNPDKNTMFFAYQSLFLNLQI 1953
            LESNHQEFIVKPEEKHEKDVSSKKSCCGRESTKVSKEVSQSDRKEV EYDPKTNTESNIDFEKEEDNIPFDFDEENQSKSQIISNDWPPKPDSLLDEEYLKNQKSNKEYRESVKKTDLDVRTPDKAKKASGRKNKKKQFELFEEHFTSSQETPDSTELANSYKDIEDEEDIQGNIHMTDEDFTIPLDDPNNFRYWPTYIYWVKPENSYSKKMGCILKAKPGGIGRHTNFECSSIYSSRILPNIDLQEDAASIPIEIKPTDPSQEFNFENPWKLILPHILPKNSPKDPVILMLSDDDTGWIEMPTSEIILDDLKEHKLRFVETKLEKRSGIFIVQTKNRTDNGIINKHGARIASSMDSRVFVSVPAGAIRITLNTTLKINTVDSSFWKELKGKFDKSPLEQVICSSHLIAFTSKKKKLIKPAIISCHLPLNAEVKKQQEVQPKTTTKKKDRAEDDEDDDNGDKQNKSFIPKIEMNAFQKSLLMSGISGANANESIKVLVYSNEEDKWNEMEKPEISTDKTKEQMSLEFPTIQSTKFFMLRANRTITFENLTKGVKLIETEFSLRNSLIILLKSAKNPYEFILLTCLKSRSEKIISQFKDDGYNVEPQNTPVSIELKERQILRTSFSGNIQNVNPDKNTMFFAYQSLFLNLQI
Sbjct: 2584 LESNHQEFIVKPEEKHEKDVSSKKSCCGRESTKVSKEVSQSDRKEVTEYDPKTNTESNIDFEKEEDNIPFDFDEENQSKSQIISNDWPPKPDSLLDEEYLKNQKSNKEYRESVKKTDLDVRTPDKAKKASGRKNKKKQFELFEEHFTSSQETPDSTELANSYKDIEDEEDIQGNIHMTDEDFTIPLDDPNNFRYWPTYIYWVKPENSYSKKMGCILKAKPGGIGRHTNFECSSIYSSRILPNIDLQEDAASIPIEIKPTDPSQEFNFENPWKLILPHILPKNSPKDPVILMLSDDDTGWIEMPTSEIILDDLKEHKLRFVETKLEKRSGIFIVQTKNRTDNGIINKHGARIASSMDSRVFVSVPAGAIRITLNTTLKINTVDSSFWKELKGKFDKSPLEQVICSSHLIAFTSKKKKLIKPAIISCHLPLNAEVKKQQEVQPKTTTKKKDRAEDDEDDDNGDKQNKSFIPKIEMNAFQKSLLMSGISGANANESIKVLVYSNEEDKWNEMEKPEISTDKTKEQMSLEFPTIQSTKFFMLRANRTITFENLTKGVKLIETEFSLRNSLIILLKSAKNPYEFILLTCLKSRSEKIISQFKDDGYNVEPQNTPVSIELKERQILRTSFSGNIQNVNPDKNTMFFAYQSLFLNLQI 3234

HSP 2 Score: 361.688 bits (927), Expect = 4.004e-106
Identity = 166/166 (100.00%), Postives = 166/166 (100.00%), Query Frame = 3 
Query: 1956 TYAQRAIDHYRGYIMVFTKKLMKKPIESADKKARKGHVQYQMVEEDFMICQLLISIPKKGLIAHKPLRNIPFNREILEDFLCMFTRIADGIGISWKELGTSLKISESRLQMLKHHNPGNQPGKIVIQMLLFWFKGLELMDDKTEMLRQSLLEVNRNDLAVMMREGT 2453
            TYAQRAIDHYRGYIMVFTKKLMKKPIESADKKARKGHVQYQMVEEDFMICQLLISIPKKGLIAHKPLRNIPFNREILEDFLCMFTRIADGIGISWKELGTSLKISESRLQMLKHHNPGNQPGKIVIQMLLFWFKGLELMDDKTEMLRQSLLEVNRNDLAVMMREGT
Sbjct: 3242 TYAQRAIDHYRGYIMVFTKKLMKKPIESADKKARKGHVQYQMVEEDFMICQLLISIPKKGLIAHKPLRNIPFNREILEDFLCMFTRIADGIGISWKELGTSLKISESRLQMLKHHNPGNQPGKIVIQMLLFWFKGLELMDDKTEMLRQSLLEVNRNDLAVMMREGT 3407
[Close]
BLAST of death domain-containing protein 1 vs. Planmine SMEST
Match: SMESG000031073.1 (SMESG000031073.1)

HSP 1 Score: 1265.75 bits (3274), Expect = 0.000e+0
Identity = 650/651 (99.85%), Postives = 650/651 (99.85%), Query Frame = 1 
Query:    1 LESNHQEFIVKPEEKHEKDVSSKKSCCGRESTKVSKEVSQSDRKEVAEYDPKTNTESNIDFEKEEDNIPFDFDEENQSKSQIISNDWPPKPDSLLDEEYLKNQKSNKEYRESVKKTDLDVRTPDXXXXXXXXXXXXXQFELFEEHFTSSQETPDSTELANSYKDIEDEEDIQGNIHMTDEDFTIPLDDPNNFRYWPTYIYWVKPENSYSKKMGCILKAKPGGIGRHTNFECSSIYSSRILPNIDLQEDAASIPIEIKPTDPSQEFNFENPWKLILPHILPKNSPKDPVILMLSDDDTGWIEMPTSEIILDDLKEHKLRFVETKLEKRSGIFIVQTKNRTDNGIINKHGARIASSMDSRVFVSVPAGAIRITLNTTLKINTVDSSFWKELKGKFDKSPLEQVICSSHLIAFTSKKKKLIKPAIISCHLPLNAEVKKQQEVQPXXXXXXXXXXXXXXXXXXXXXXXXSFIPKIEMNAFQKSLLMSGISGANANESIKVLVYSNEEDKWNEMEKPEISTDKTKEQMSLEFPTIQSTKFFMLRANRTITFENLTKGVKLIETEFSLRNSLIILLKSAKNPYEFILLTCLKSRSEKIISQFKDDGYNVEPQNTPVSIELKERQILRTSFSGNIQNVNPDKNTMFFAYQSLFLNLQI 1953
            LESNHQEFIVKPEEKHEKDVSSKKSCCGRESTKVSKEVSQSDRKEV EYDPKTNTESNIDFEKEEDNIPFDFDEENQSKSQIISNDWPPKPDSLLDEEYLKNQKSNKEYRESVKKTDLDVRTPDKAKKASGRKNKKKQFELFEEHFTSSQETPDSTELANSYKDIEDEEDIQGNIHMTDEDFTIPLDDPNNFRYWPTYIYWVKPENSYSKKMGCILKAKPGGIGRHTNFECSSIYSSRILPNIDLQEDAASIPIEIKPTDPSQEFNFENPWKLILPHILPKNSPKDPVILMLSDDDTGWIEMPTSEIILDDLKEHKLRFVETKLEKRSGIFIVQTKNRTDNGIINKHGARIASSMDSRVFVSVPAGAIRITLNTTLKINTVDSSFWKELKGKFDKSPLEQVICSSHLIAFTSKKKKLIKPAIISCHLPLNAEVKKQQEVQPKTTTKKKDRAEDDEDDDNGDKQNKSFIPKIEMNAFQKSLLMSGISGANANESIKVLVYSNEEDKWNEMEKPEISTDKTKEQMSLEFPTIQSTKFFMLRANRTITFENLTKGVKLIETEFSLRNSLIILLKSAKNPYEFILLTCLKSRSEKIISQFKDDGYNVEPQNTPVSIELKERQILRTSFSGNIQNVNPDKNTMFFAYQSLFLNLQI
Sbjct: 2552 LESNHQEFIVKPEEKHEKDVSSKKSCCGRESTKVSKEVSQSDRKEVTEYDPKTNTESNIDFEKEEDNIPFDFDEENQSKSQIISNDWPPKPDSLLDEEYLKNQKSNKEYRESVKKTDLDVRTPDKAKKASGRKNKKKQFELFEEHFTSSQETPDSTELANSYKDIEDEEDIQGNIHMTDEDFTIPLDDPNNFRYWPTYIYWVKPENSYSKKMGCILKAKPGGIGRHTNFECSSIYSSRILPNIDLQEDAASIPIEIKPTDPSQEFNFENPWKLILPHILPKNSPKDPVILMLSDDDTGWIEMPTSEIILDDLKEHKLRFVETKLEKRSGIFIVQTKNRTDNGIINKHGARIASSMDSRVFVSVPAGAIRITLNTTLKINTVDSSFWKELKGKFDKSPLEQVICSSHLIAFTSKKKKLIKPAIISCHLPLNAEVKKQQEVQPKTTTKKKDRAEDDEDDDNGDKQNKSFIPKIEMNAFQKSLLMSGISGANANESIKVLVYSNEEDKWNEMEKPEISTDKTKEQMSLEFPTIQSTKFFMLRANRTITFENLTKGVKLIETEFSLRNSLIILLKSAKNPYEFILLTCLKSRSEKIISQFKDDGYNVEPQNTPVSIELKERQILRTSFSGNIQNVNPDKNTMFFAYQSLFLNLQI 3202

HSP 2 Score: 361.303 bits (926), Expect = 4.730e-106
Identity = 166/166 (100.00%), Postives = 166/166 (100.00%), Query Frame = 3 
Query: 1956 TYAQRAIDHYRGYIMVFTKKLMKKPIESADKKARKGHVQYQMVEEDFMICQLLISIPKKGLIAHKPLRNIPFNREILEDFLCMFTRIADGIGISWKELGTSLKISESRLQMLKHHNPGNQPGKIVIQMLLFWFKGLELMDDKTEMLRQSLLEVNRNDLAVMMREGT 2453
            TYAQRAIDHYRGYIMVFTKKLMKKPIESADKKARKGHVQYQMVEEDFMICQLLISIPKKGLIAHKPLRNIPFNREILEDFLCMFTRIADGIGISWKELGTSLKISESRLQMLKHHNPGNQPGKIVIQMLLFWFKGLELMDDKTEMLRQSLLEVNRNDLAVMMREGT
Sbjct: 3210 TYAQRAIDHYRGYIMVFTKKLMKKPIESADKKARKGHVQYQMVEEDFMICQLLISIPKKGLIAHKPLRNIPFNREILEDFLCMFTRIADGIGISWKELGTSLKISESRLQMLKHHNPGNQPGKIVIQMLLFWFKGLELMDDKTEMLRQSLLEVNRNDLAVMMREGT 3375
[Close]
BLAST of death domain-containing protein 1 vs. Planmine SMEST
Match: SMESG000031073.1 (SMESG000031073.1)

HSP 1 Score: 1146.34 bits (2964), Expect = 0.000e+0
Identity = 592/596 (99.33%), Postives = 593/596 (99.50%), Query Frame = 1 
Query:    1 LESNHQEFIVKPEEKHEKDVSSKKSCCGRESTKVSKEVSQSDRKEVAEYDPKTNTESNIDFEKEEDNIPFDFDEENQSKSQIISNDWPPKPDSLLDEEYLKNQKSNKEYRESVKKTDLDVRTPDXXXXXXXXXXXXXQFELFEEHFTSSQETPDSTELANSYKDIEDEEDIQGNIHMTDEDFTIPLDDPNNFRYWPTYIYWVKPENSYSKKMGCILKAKPGGIGRHTNFECSSIYSSRILPNIDLQEDAASIPIEIKPTDPSQEFNFENPWKLILPHILPKNSPKDPVILMLSDDDTGWIEMPTSEIILDDLKEHKLRFVETKLEKRSGIFIVQTKNRTDNGIINKHGARIASSMDSRVFVSVPAGAIRITLNTTLKINTVDSSFWKELKGKFDKSPLEQVICSSHLIAFTSKKKKLIKPAIISCHLPLNAEVKKQQEVQPXXXXXXXXXXXXXXXXXXXXXXXXSFIPKIEMNAFQKSLLMSGISGANANESIKVLVYSNEEDKWNEMEKPEISTDKTKEQMSLEFPTIQSTKFFMLRANRTITFENLTKGVKLIETEFSLRNSLIILLKSAKNPYEFILLTCLKSRSEKIISQF 1788
            LESNHQEFIVKPEEKHEKDVSSKKSCCGRESTKVSKEVSQSDRKEV EYDPKTNTESNIDFEKEEDNIPFDFDEENQSKSQIISNDWPPKPDSLLDEEYLKNQKSNKEYRESVKKTDLDVRTPDKAKKASGRKNKKKQFELFEEHFTSSQETPDSTELANSYKDIEDEEDIQGNIHMTDEDFTIPLDDPNNFRYWPTYIYWVKPENSYSKKMGCILKAKPGGIGRHTNFECSSIYSSRILPNIDLQEDAASIPIEIKPTDPSQEFNFENPWKLILPHILPKNSPKDPVILMLSDDDTGWIEMPTSEIILDDLKEHKLRFVETKLEKRSGIFIVQTKNRTDNGIINKHGARIASSMDSRVFVSVPAGAIRITLNTTLKINTVDSSFWKELKGKFDKSPLEQVICSSHLIAFTSKKKKLIKPAIISCHLPLNAEVKKQQEVQPKTTTKKKDRAEDDEDDDNGDKQNKSFIPKIEMNAFQKSLLMSGISGANANESIKVLVYSNEEDKWNEMEKPEISTDKTKEQMSLEFPTIQSTKFFMLRANRTITFENLTKGVKLIETEFSLRNSLIILLKSAKNPYEFILLTCLKSRSEKII  +
Sbjct: 2585 LESNHQEFIVKPEEKHEKDVSSKKSCCGRESTKVSKEVSQSDRKEVTEYDPKTNTESNIDFEKEEDNIPFDFDEENQSKSQIISNDWPPKPDSLLDEEYLKNQKSNKEYRESVKKTDLDVRTPDKAKKASGRKNKKKQFELFEEHFTSSQETPDSTELANSYKDIEDEEDIQGNIHMTDEDFTIPLDDPNNFRYWPTYIYWVKPENSYSKKMGCILKAKPGGIGRHTNFECSSIYSSRILPNIDLQEDAASIPIEIKPTDPSQEFNFENPWKLILPHILPKNSPKDPVILMLSDDDTGWIEMPTSEIILDDLKEHKLRFVETKLEKRSGIFIVQTKNRTDNGIINKHGARIASSMDSRVFVSVPAGAIRITLNTTLKINTVDSSFWKELKGKFDKSPLEQVICSSHLIAFTSKKKKLIKPAIISCHLPLNAEVKKQQEVQPKTTTKKKDRAEDDEDDDNGDKQNKSFIPKIEMNAFQKSLLMSGISGANANESIKVLVYSNEEDKWNEMEKPEISTDKTKEQMSLEFPTIQSTKFFMLRANRTITFENLTKGVKLIETEFSLRNSLIILLKSAKNPYEFILLTCLKSRSEKIIKHY 3180

HSP 2 Score: 399.053 bits (1024), Expect = 6.332e-119
Identity = 182/182 (100.00%), Postives = 182/182 (100.00%), Query Frame = 3 
Query: 1908 HYVLCLPVAVSKPSNYTYAQRAIDHYRGYIMVFTKKLMKKPIESADKKARKGHVQYQMVEEDFMICQLLISIPKKGLIAHKPLRNIPFNREILEDFLCMFTRIADGIGISWKELGTSLKISESRLQMLKHHNPGNQPGKIVIQMLLFWFKGLELMDDKTEMLRQSLLEVNRNDLAVMMREGT 2453
            HYVLCLPVAVSKPSNYTYAQRAIDHYRGYIMVFTKKLMKKPIESADKKARKGHVQYQMVEEDFMICQLLISIPKKGLIAHKPLRNIPFNREILEDFLCMFTRIADGIGISWKELGTSLKISESRLQMLKHHNPGNQPGKIVIQMLLFWFKGLELMDDKTEMLRQSLLEVNRNDLAVMMREGT
Sbjct: 3179 HYVLCLPVAVSKPSNYTYAQRAIDHYRGYIMVFTKKLMKKPIESADKKARKGHVQYQMVEEDFMICQLLISIPKKGLIAHKPLRNIPFNREILEDFLCMFTRIADGIGISWKELGTSLKISESRLQMLKHHNPGNQPGKIVIQMLLFWFKGLELMDDKTEMLRQSLLEVNRNDLAVMMREGT 3360
[Close]
BLAST of death domain-containing protein 1 vs. Planmine SMEST
Match: SMESG000073578.1 (SMESG000073578.1)

HSP 1 Score: 280.796 bits (717), Expect = 1.104e-99
Identity = 166/464 (35.78%), Postives = 269/464 (57.97%), Query Frame = 1 
Query:  559 DDPNNFRYWPTYIYWVKPENSYSKKMGCILKAKPGGIGRHTNFECSSIYSSRILPNIDLQEDAASIPIEIKPTDPSQEFNFENPWKLILPHILPKNSPKDPVILMLSDDDTGWIEMPTSEIILDDLKEHKLRFVETKLEKRSGIFIVQTKNRTDNGIINKHGARIASSMDSRVFVSVPAGAIRITLNTTLKINTVDSSFWKELKGKFDKSPLEQVICSSHLIAFTSKKKKLIKPAIISCHLPLNAEVKKQQEVQPXXXXXXXXXXXXXXXXXXXXXXXXSFIPKIEMNAFQKSLLMSGISGANANESIKVLVYSNEEDKWNEMEKPEISTDKTKEQMSLEFPTIQSTKFFMLRANRTITFENLTKGVKLIETEFSLRNSLIILLKSAKNPYEFILLTCLKSRSEKIISQFKDDGYNVEPQNTPVSIELKERQILRTSFSGNIQNVNPDKNTMFFAYQSLFLNLQ 1950
            D+ NN ++W  + Y++KP N Y K + C+++AKPG I +  N +C  + S   +P +D +E+ AS   +I P D   +F FE PW L +P+    N  K+P+I++ +++   W+E PTSE+  D+ K++ L FVETK+ K +GIF V +    D  +I+K G +I    D  V  SVP  +++I++ T +++ ++D+ FWKE+K K  KS L+Q+  +S +I   +KKKKL  PA ++  L  N  V K Q+V  K   K+ +  ED + +D           K E+N FQK+LLM  I+  NA   I +L Y +EED+W   ++  +  +  K Q+S++   +QS+KF +L++ R    E LTK  KLIE EF +RN +I L +SA+   +F L+  LK   +  I    ++GY ++ +N  V +EL ERQI+ + F  N++N+N +     F + +L  N+ 
Sbjct:  464 DEINNPKFWKKHYYYIKPPNLYDKTLACVIRAKPGSIVKKKNLKCELLNSEEEIPYLDKRENYASYIFKISPIDSEAQFQFETPWHLAIPYYPLLNKVKEPIIMIKNEELNKWMESPTSEVSFDNEKQNVLNFVETKIFKPNGIFAVVSSLCKDVIVISKEGNQITCISDRNVSFSVPQDSLKISITTCIQVVSIDNLFWKEIKEKHGKSLLDQINFTSSIIEIEAKKKKLTIPASLTMKLLDN--VVKDQDVNLKKEKKETNEDEDVKLEDKI------LTLKKELNPFQKTLLMEKINNTNAIRDIHLLNYLHEEDRWFVTKENALIFNSNKNQVSIQIQILQSSKFIILQSKRNTNEETLTKVAKLIENEFCVRNCIIALFQSAQIQNQFALIISLKKYFQNNIKVLLEEGYILDSRNDLVHVELHERQIITSKFVENVKNINHNTFQSLFTFHTLLPNIH 919

HSP 2 Score: 103.605 bits (257), Expect = 1.104e-99
Identity = 52/150 (34.67%), Postives = 86/150 (57.33%), Query Frame = 3 
Query: 1956 TYAQRAIDHYRGYIMVFTKKLMKKPIESADKKARKGHVQYQMVEEDFMICQLLISIPKKGLIAHKPLRNIPFNREILEDFLCMFTRIADGIGISWKELGTSLKISESRLQMLKHHNPGNQPGKIVIQMLLFWFKGLELMDDKTEMLRQSL 2405
            ++AQRA+  +RGY+ ++   L++KPI + + K RK  +QY  VEE+ MI   LI I KK +       +  F  +  +    +  +I+  IG +W +LG  L ++E+R+Q +K HN      K+   MLLFW KG E  ++K ++L+ +L
Sbjct:  928 SHAQRAVLTFRGYLNLYITSLVRKPINNTESKIRKNQIQYTWVEENIMISHFLICINKKKIPLSPSFIDYHFKFKNYKTCFTIIKKISGKIGYNWWDLGLHLGVTETRMQSIKLHNETRGINKMAENMLLFWLKGCETQENKLDLLKTAL 1077
[Close]
BLAST of death domain-containing protein 1 vs. Planmine SMEST
Match: SMESG000073578.1 (SMESG000073578.1)

HSP 1 Score: 280.796 bits (717), Expect = 1.229e-99
Identity = 166/464 (35.78%), Postives = 269/464 (57.97%), Query Frame = 1 
Query:  559 DDPNNFRYWPTYIYWVKPENSYSKKMGCILKAKPGGIGRHTNFECSSIYSSRILPNIDLQEDAASIPIEIKPTDPSQEFNFENPWKLILPHILPKNSPKDPVILMLSDDDTGWIEMPTSEIILDDLKEHKLRFVETKLEKRSGIFIVQTKNRTDNGIINKHGARIASSMDSRVFVSVPAGAIRITLNTTLKINTVDSSFWKELKGKFDKSPLEQVICSSHLIAFTSKKKKLIKPAIISCHLPLNAEVKKQQEVQPXXXXXXXXXXXXXXXXXXXXXXXXSFIPKIEMNAFQKSLLMSGISGANANESIKVLVYSNEEDKWNEMEKPEISTDKTKEQMSLEFPTIQSTKFFMLRANRTITFENLTKGVKLIETEFSLRNSLIILLKSAKNPYEFILLTCLKSRSEKIISQFKDDGYNVEPQNTPVSIELKERQILRTSFSGNIQNVNPDKNTMFFAYQSLFLNLQ 1950
            D+ NN ++W  + Y++KP N Y K + C+++AKPG I +  N +C  + S   +P +D +E+ AS   +I P D   +F FE PW L +P+    N  K+P+I++ +++   W+E PTSE+  D+ K++ L FVETK+ K +GIF V +    D  +I+K G +I    D  V  SVP  +++I++ T +++ ++D+ FWKE+K K  KS L+Q+  +S +I   +KKKKL  PA ++  L  N  V K Q+V  K   K+ +  ED + +D           K E+N FQK+LLM  I+  NA   I +L Y +EED+W   ++  +  +  K Q+S++   +QS+KF +L++ R    E LTK  KLIE EF +RN +I L +SA+   +F L+  LK   +  I    ++GY ++ +N  V +EL ERQI+ + F  N++N+N +     F + +L  N+ 
Sbjct:  516 DEINNPKFWKKHYYYIKPPNLYDKTLACVIRAKPGSIVKKKNLKCELLNSEEEIPYLDKRENYASYIFKISPIDSEAQFQFETPWHLAIPYYPLLNKVKEPIIMIKNEELNKWMESPTSEVSFDNEKQNVLNFVETKIFKPNGIFAVVSSLCKDVIVISKEGNQITCISDRNVSFSVPQDSLKISITTCIQVVSIDNLFWKEIKEKHGKSLLDQINFTSSIIEIEAKKKKLTIPASLTMKLLDN--VVKDQDVNLKKEKKETNEDEDVKLEDKI------LTLKKELNPFQKTLLMEKINNTNAIRDIHLLNYLHEEDRWFVTKENALIFNSNKNQVSIQIQILQSSKFIILQSKRNTNEETLTKVAKLIENEFCVRNCIIALFQSAQIQNQFALIISLKKYFQNNIKVLLEEGYILDSRNDLVHVELHERQIITSKFVENVKNINHNTFQSLFTFHTLLPNIH 971

HSP 2 Score: 103.605 bits (257), Expect = 1.229e-99
Identity = 52/150 (34.67%), Postives = 86/150 (57.33%), Query Frame = 3 
Query: 1956 TYAQRAIDHYRGYIMVFTKKLMKKPIESADKKARKGHVQYQMVEEDFMICQLLISIPKKGLIAHKPLRNIPFNREILEDFLCMFTRIADGIGISWKELGTSLKISESRLQMLKHHNPGNQPGKIVIQMLLFWFKGLELMDDKTEMLRQSL 2405
            ++AQRA+  +RGY+ ++   L++KPI + + K RK  +QY  VEE+ MI   LI I KK +       +  F  +  +    +  +I+  IG +W +LG  L ++E+R+Q +K HN      K+   MLLFW KG E  ++K ++L+ +L
Sbjct:  980 SHAQRAVLTFRGYLNLYITSLVRKPINNTESKIRKNQIQYTWVEENIMISHFLICINKKKIPLSPSFIDYHFKFKNYKTCFTIIKKISGKIGYNWWDLGLHLGVTETRMQSIKLHNETRGINKMAENMLLFWLKGCETQENKLDLLKTAL 1129
The following BLAST results are available for this feature:
BLAST of death domain-containing protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of death domain-containing protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of death domain-containing protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of death domain-containing protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of death domain-containing protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of death domain-containing protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of death domain-containing protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of death domain-containing protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
K1S6Z01.545e-4326.46Uncharacterized protein OS=Crassostrea gigas OX=29... [more]
A0A210QUR42.947e-3822.22Death domain-containing protein 1 OS=Mizuhopecten ... [more]
V3ZPR46.527e-3824.74Uncharacterized protein OS=Lottia gigantea OX=2251... [more]
A0A1S3HDZ31.141e-3425.17death domain-containing protein 1 OS=Lingula ungui... [more]
A0A158R6G93.614e-3021.93Death domain-containing protein OS=Taenia asiatica... [more]
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BLAST of death domain-containing protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of death domain-containing protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of death domain-containing protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of death domain-containing protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of death domain-containing protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of death domain-containing protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000031073.14.004e-10699.85SMESG000031073.1[more]
SMESG000031073.14.730e-10699.85SMESG000031073.1[more]
SMESG000031073.16.332e-11999.33SMESG000031073.1[more]
SMESG000073578.11.104e-9935.78SMESG000073578.1[more]
SMESG000073578.11.229e-9935.78SMESG000073578.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30024895 ID=SMED30024895|Name=death domain-containing protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=2600bp
CTAGAATCTAATCATCAAGAGTTTATTGTAAAACCGGAAGAAAAACATGA
AAAAGATGTAAGTTCGAAAAAGTCATGCTGTGGTCGAGAGTCTACTAAAG
TTAGCAAAGAGGTTTCACAGAGCGATAGGAAAGAAGTCGCCGAATACGAT
CCCAAAACGAACACAGAATCGAATATAGATTTTGAAAAGGAAGAAGATAA
TATTCCGTTTGATTTTGATGAAGAAAATCAAAGTAAATCACAAATAATAT
CAAACGATTGGCCACCAAAACCAGATAGTTTATTGGATGAAGAATATTTA
AAAAATCAGAAATCAAATAAAGAATATCGAGAATCTGTGAAAAAAACCGA
TTTAGACGTAAGGACTCCAGATAAAGCTAAAAAGGCAAGTGGACGAAAAA
ATAAGAAAAAGCAGTTTGAACTTTTTGAAGAACATTTTACAAGTTCTCAA
GAAACACCAGATTCTACAGAACTAGCGAATTCATACAAAGATATTGAGGA
CGAAGAAGATATCCAAGGAAATATTCATATGACTGACGAGGACTTTACTA
TTCCGTTAGATGATCCGAATAACTTCAGATACTGGCCAACATACATATAT
TGGGTCAAGCCTGAAAATTCGTATAGCAAGAAGATGGGATGCATTTTAAA
AGCCAAACCAGGCGGAATAGGTCGCCATACTAATTTTGAGTGTAGTTCTA
TTTATTCGTCCAGAATACTGCCTAATATAGATTTGCAAGAGGATGCTGCA
AGTATTCCCATAGAAATCAAACCAACAGATCCATCTCAAGAGTTCAATTT
TGAAAACCCATGGAAACTAATTTTACCGCACATTTTACCAAAGAACAGTC
CAAAAGATCCAGTAATTTTAATGCTAAGTGACGATGACACTGGGTGGATT
GAAATGCCAACTTCAGAAATCATATTAGATGATCTCAAAGAACACAAACT
TAGATTTGTCGAAACGAAATTGGAGAAACGTTCGGGAATATTTATCGTTC
AAACTAAAAACCGAACAGATAATGGTATCATAAATAAACACGGAGCACGA
ATCGCAAGTTCAATGGATAGTCGTGTTTTCGTGTCGGTCCCTGCGGGTGC
CATTAGAATTACGCTCAATACCACATTAAAAATAAATACAGTAGATTCTT
CTTTTTGGAAAGAGTTGAAAGGCAAATTTGACAAAAGCCCCTTGGAACAA
GTGATCTGCTCATCTCATTTAATAGCTTTCACATCAAAAAAGAAAAAACT
TATCAAGCCTGCAATAATCAGTTGTCATTTACCATTAAATGCAGAAGTGA
AGAAACAACAGGAAGTTCAGCCTAAAACAACAACTAAGAAAAAGGATAGG
GCTGAAGATGATGAAGACGACGACAATGGAGATAAACAAAACAAGTCATT
TATACCAAAAATTGAGATGAATGCTTTCCAAAAATCTCTATTAATGTCCG
GAATTAGTGGAGCTAACGCCAACGAAAGCATAAAGGTTTTGGTATATTCT
AACGAGGAGGATAAATGGAATGAAATGGAAAAACCGGAAATATCTACAGA
TAAAACAAAAGAACAAATGAGCTTAGAATTTCCGACAATACAATCAACCA
AATTTTTCATGCTGAGAGCCAACCGAACGATCACATTTGAAAATTTGACA
AAAGGTGTTAAATTAATCGAGACAGAATTTTCTTTGAGAAATTCATTGAT
AATTTTATTGAAATCTGCGAAAAATCCGTATGAATTCATATTGTTAACCT
GTCTGAAGAGTCGATCTGAAAAAATAATCAGTCAGTTCAAAGACGATGGT
TACAATGTAGAGCCCCAGAATACACCGGTTTCAATAGAGTTAAAAGAAAG
ACAAATATTGAGGACATCTTTCTCAGGAAATATCCAAAATGTAAATCCTG
ATAAGAACACTATGTTCTTTGCTTACCAGTCGCTGTTTCTAAACCTTCAA
ATTATACCTATGCACAAAGAGCAATAGACCATTATCGAGGATATATTATG
GTTTTCACAAAAAAATTAATGAAAAAACCAATAGAATCAGCAGACAAAAA
AGCAAGGAAGGGACATGTTCAATATCAAATGGTAGAAGAAGACTTCATGA
TCTGCCAACTTCTTATATCAATTCCTAAAAAGGGTTTAATTGCACACAAA
CCTTTAAGAAACATTCCATTCAATAGGGAAATACTCGAGGATTTCTTGTG
CATGTTTACCAGAATTGCAGACGGAATCGGTATTTCCTGGAAAGAATTAG
GAACATCACTGAAAATTTCAGAATCTCGATTACAAATGCTTAAGCATCAC
AATCCTGGTAACCAACCAGGAAAAATAGTCATACAAATGCTATTGTTTTG
GTTTAAAGGGTTAGAATTAATGGATGATAAAACGGAAATGCTGAGACAGT
CTTTACTAGAAGTTAATCGTAATGATTTAGCAGTTATGATGAGAGAAGGT
ACTGATGAGGATGACAGCTCTTTATCAGCTACTGATTCATAAATATAAAG
TCTATACTTTGAAAATAACTTTAATTAAATATATTAAAAATATATTGTTT
CATAATGACTTATTATCAAAAGTTCACGAAATCATATATATTAAAAGGTG
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protein sequence of SMED30024895-orf-1

>SMED30024895-orf-1 ID=SMED30024895-orf-1|Name=SMED30024895-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=165bp
MVFTKKLMKKPIESADKKARKGHVQYQMVEEDFMICQLLISIPKKGLIAH
KPLRNIPFNREILEDFLCMFTRIADGIGISWKELGTSLKISESRLQMLKH
HNPGNQPGKIVIQMLLFWFKGLELMDDKTEMLRQSLLEVNRNDLAVMMRE
GTDEDDSSLSATDS*
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protein sequence of SMED30024895-orf-2

>SMED30024895-orf-2 ID=SMED30024895-orf-2|Name=SMED30024895-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=659bp
LESNHQEFIVKPEEKHEKDVSSKKSCCGRESTKVSKEVSQSDRKEVAEYD
PKTNTESNIDFEKEEDNIPFDFDEENQSKSQIISNDWPPKPDSLLDEEYL
KNQKSNKEYRESVKKTDLDVRTPDKAKKASGRKNKKKQFELFEEHFTSSQ
ETPDSTELANSYKDIEDEEDIQGNIHMTDEDFTIPLDDPNNFRYWPTYIY
WVKPENSYSKKMGCILKAKPGGIGRHTNFECSSIYSSRILPNIDLQEDAA
SIPIEIKPTDPSQEFNFENPWKLILPHILPKNSPKDPVILMLSDDDTGWI
EMPTSEIILDDLKEHKLRFVETKLEKRSGIFIVQTKNRTDNGIINKHGAR
IASSMDSRVFVSVPAGAIRITLNTTLKINTVDSSFWKELKGKFDKSPLEQ
VICSSHLIAFTSKKKKLIKPAIISCHLPLNAEVKKQQEVQPKTTTKKKDR
AEDDEDDDNGDKQNKSFIPKIEMNAFQKSLLMSGISGANANESIKVLVYS
NEEDKWNEMEKPEISTDKTKEQMSLEFPTIQSTKFFMLRANRTITFENLT
KGVKLIETEFSLRNSLIILLKSAKNPYEFILLTCLKSRSEKIISQFKDDG
YNVEPQNTPVSIELKERQILRTSFSGNIQNVNPDKNTMFFAYQSLFLNLQ
IIPMHKEQ*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002089reproductive organ
Vocabulary: INTERPRO
TermDefinition
IPR011029DEATH-like_dom_sf
IPR000488Death_domain
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
Vocabulary: biological process
TermDefinition
GO:0007165signal transduction
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableGENE3DG3DSA:2.60.220.30coord: 335..553
e-value: 4.9E-7
score: 31.3
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 435..466
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1..65
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 91..127
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 439..453
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1..135