c-Myc-binding protein

Overview
Namec-Myc-binding protein
Smed IDSMED30024869
Length (bp)405
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of c-Myc-binding protein (SMED30024869) t-SNE clustered cells

Violin plots show distribution of expression levels for c-Myc-binding protein (SMED30024869) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of c-Myc-binding protein (SMED30024869) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for c-Myc-binding protein (SMED30024869) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30024869

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30024869 dd_Smed_v4_12156_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30024869 dd_Smed_v4_12156_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30024869 dd_Smed_v4_12156_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30024869 dd_Smed_v6_12156_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
epidermisSMED30024869 dd_Smed_v4_12156_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of c-Myc-binding protein vs. Ensembl Human
Match: MYCBP (MYC binding protein [Source:HGNC Symbol;Acc:HGNC:7554])

HSP 1 Score: 66.6254 bits (161), Expect = 1.022e-14
Identity = 30/82 (36.59%), Postives = 58/82 (70.73%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEY 371
            +++R+YL++SG+ D L KVL  +Y+EPEKP  AL++++++L    P  PE+E L++ + E++ +   +  +NK+L  K+++Y
Sbjct:   12 EQFRRYLEKSGVLDTLTKVLVALYEEPEKPNSALDFLKHHLGAATPENPEIELLRLELAEMKEKYEAIVEENKKLKAKLAQY 93          
BLAST of c-Myc-binding protein vs. Ensembl Human
Match: AL139260.3 (novel protein)

HSP 1 Score: 65.855 bits (159), Expect = 1.867e-14
Identity = 30/82 (36.59%), Postives = 58/82 (70.73%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEY 371
            +++R+YL++SG+ D L KVL  +Y+EPEKP  AL++++++L    P  PE+E L++ + E++ +   +  +NK+L  K+++Y
Sbjct:   19 EQFRRYLEKSGVLDTLTKVLVALYEEPEKPNSALDFLKHHLGAATPENPEIELLRLELAEMKEKYEAIVEENKKLKAKLAQY 100          
BLAST of c-Myc-binding protein vs. Ensembl Fly
Match: CG4546 (gene:FBgn0038373 transcript:FBtr0083184)

HSP 1 Score: 47.3654 bits (111), Expect = 7.352e-7
Identity = 26/71 (36.62%), Postives = 42/71 (59.15%), Query Frame = 3
Query:  120 RIQEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPE-------LEELKISVKELE 311
            R+Q YRKYL+R+G+ D L K L  +Y+E  KP +A+ ++R  + +  P+  +       LEE K  + +LE
Sbjct:    8 RVQ-YRKYLERAGVIDALSKALIKLYEEQNKPEDAIRFVRKFMCESCPDDAQYDVMKNDLEEAKTHISKLE 77          
BLAST of c-Myc-binding protein vs. Ensembl Zebrafish
Match: mycbp (MYC binding protein [Source:ZFIN;Acc:ZDB-GENE-060331-97])

HSP 1 Score: 50.8322 bits (120), Expect = 1.249e-8
Identity = 24/83 (28.92%), Postives = 52/83 (62.65%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEYK 374
            +++R+YL+++G+ D+L  VL  +Y+E EKP  AL++I+++L        + E L+  +  L+ +   +  +N+EL  ++ +Y+
Sbjct:   30 EQFRRYLEKAGVLDSLTNVLVALYEETEKPNNALDFIKHHLGVSGVEAEDAESLREELNTLQQKHQQLMEENQELKSRLLQYE 112          
BLAST of c-Myc-binding protein vs. Ensembl Xenopus
Match: adrb2 (adrenoceptor beta 2 [Source:Xenbase;Acc:XB-GENE-494302])

HSP 1 Score: 65.0846 bits (157), Expect = 3.188e-14
Identity = 28/82 (34.15%), Postives = 56/82 (68.29%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEY 371
            +++R+YL+++G+ D L KVL  +Y+EPEKP  AL++++ ++    P   ++E L++ V EL+ +   +  +NKEL  K++++
Sbjct:    8 EQFRRYLEKAGVLDTLTKVLVALYEEPEKPNNALDFLKQHMGAAGPETADVEALRLEVAELKQKYEAVLEENKELKAKLAQH 89          
BLAST of c-Myc-binding protein vs. Ensembl Xenopus
Match: adrb2 (adrenoceptor beta 2 [Source:Xenbase;Acc:XB-GENE-494302])

HSP 1 Score: 65.0846 bits (157), Expect = 3.368e-14
Identity = 28/82 (34.15%), Postives = 56/82 (68.29%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEY 371
            +++R+YL+++G+ D L KVL  +Y+EPEKP  AL++++ ++    P   ++E L++ V EL+ +   +  +NKEL  K++++
Sbjct:   12 EQFRRYLEKAGVLDTLTKVLVALYEEPEKPNNALDFLKQHMGAAGPETADVEALRLEVAELKQKYEAVLEENKELKAKLAQH 93          
BLAST of c-Myc-binding protein vs. Ensembl Mouse
Match: Mycbp (MYC binding protein [Source:MGI Symbol;Acc:MGI:1891750])

HSP 1 Score: 65.855 bits (159), Expect = 1.325e-14
Identity = 30/82 (36.59%), Postives = 56/82 (68.29%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEY 371
            +++R+YL++SG+ D L KVL  +Y+EPEKP  AL++++++L    P  PE+E L++ + E++ +      +NK+L  K+ +Y
Sbjct:   12 EQFRRYLEKSGVLDTLTKVLVALYEEPEKPTSALDFLKHHLGAATPENPEIELLRLELAEMKEKYEATVEENKKLKAKLVQY 93          
BLAST of c-Myc-binding protein vs. Ensembl Mouse
Match: Mycbp (MYC binding protein [Source:MGI Symbol;Acc:MGI:1891750])

HSP 1 Score: 62.7734 bits (151), Expect = 5.857e-13
Identity = 25/61 (40.98%), Postives = 45/61 (73.77%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKEL 308
            +++R+YL++SG+ D L KVL  +Y+EPEKP  AL++++++L    P  PE+E L++ + E+
Sbjct:   12 EQFRRYLEKSGVLDTLTKVLVALYEEPEKPTSALDFLKHHLGAATPENPEIELLRLELAEM 72          
BLAST of c-Myc-binding protein vs. UniProt/SwissProt
Match: sp|Q99417|MYCBP_HUMAN (c-Myc-binding protein OS=Homo sapiens OX=9606 GN=MYCBP PE=1 SV=3)

HSP 1 Score: 66.6254 bits (161), Expect = 4.909e-14
Identity = 30/82 (36.59%), Postives = 58/82 (70.73%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEY 371
            +++R+YL++SG+ D L KVL  +Y+EPEKP  AL++++++L    P  PE+E L++ + E++ +   +  +NK+L  K+++Y
Sbjct:   12 EQFRRYLEKSGVLDTLTKVLVALYEEPEKPNSALDFLKHHLGAATPENPEIELLRLELAEMKEKYEAIVEENKKLKAKLAQY 93          
BLAST of c-Myc-binding protein vs. UniProt/SwissProt
Match: sp|Q5R7A8|MYCBP_PONAB (c-Myc-binding protein OS=Pongo abelii OX=9601 GN=MYCBP PE=3 SV=3)

HSP 1 Score: 66.2402 bits (160), Expect = 5.527e-14
Identity = 30/82 (36.59%), Postives = 58/82 (70.73%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEY 371
            +++R+YL++SG+ D L KVL  +Y+EPEKP  AL++++++L    P  PE+E L++ + E++ +   +  +NK+L  K+++Y
Sbjct:   12 EQFRRYLEKSGVLDTLTKVLVALYEEPEKPNSALDFLKHHLGAATPENPEIELLRLELAEIKEKYEAIVEENKKLKAKLAQY 93          
BLAST of c-Myc-binding protein vs. UniProt/SwissProt
Match: sp|Q2TBP7|MYCBP_BOVIN (c-Myc-binding protein OS=Bos taurus OX=9913 GN=MYCBP PE=3 SV=3)

HSP 1 Score: 66.2402 bits (160), Expect = 5.709e-14
Identity = 30/82 (36.59%), Postives = 58/82 (70.73%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEY 371
            +++R+YL++SG+ D L KVL  +Y+EPEKP  AL++++++L    P  PE+E L++ + E++ +   +  +NK+L  K+++Y
Sbjct:   12 EQFRRYLEKSGVLDTLTKVLVALYEEPEKPNSALDFLKHHLGAATPENPEIELLRLELAEMKEKYEAIVEENKKLKTKLAQY 93          
BLAST of c-Myc-binding protein vs. UniProt/SwissProt
Match: sp|Q9EQS3|MYCBP_MOUSE (c-Myc-binding protein OS=Mus musculus OX=10090 GN=Mycbp PE=1 SV=5)

HSP 1 Score: 65.855 bits (159), Expect = 9.270e-14
Identity = 30/82 (36.59%), Postives = 56/82 (68.29%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEY 371
            +++R+YL++SG+ D L KVL  +Y+EPEKP  AL++++++L    P  PE+E L++ + E++ +      +NK+L  K+ +Y
Sbjct:   12 EQFRRYLEKSGVLDTLTKVLVALYEEPEKPTSALDFLKHHLGAATPENPEIELLRLELAEMKEKYEATVEENKKLKAKLVQY 93          
BLAST of c-Myc-binding protein vs. UniProt/SwissProt
Match: sp|Q54I57|MYCBP_DICDI (c-Myc-binding protein homolog OS=Dictyostelium discoideum OX=44689 GN=mycbp PE=3 SV=1)

HSP 1 Score: 53.9138 bits (128), Expect = 3.114e-9
Identity = 30/76 (39.47%), Postives = 46/76 (60.53%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIR----NNLSQDPPNIP-ELEELKISVKELEMRCLDMQMK 338
            +E++ YL++SG+ D L KVL G+Y+E +KP +ALE+I+    N+L  D   +  E  +LK  V  L  R  D+  K
Sbjct:    8 EEFKGYLEKSGVIDALTKVLVGLYEESDKPSDALEFIKKHLGNSLGIDVDALKQENADLKAEVSALTQRVDDLSKK 83          
BLAST of c-Myc-binding protein vs. TrEMBL
Match: A0A1I8GVQ6 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig017412g1 PE=4 SV=1)

HSP 1 Score: 78.9518 bits (193), Expect = 2.107e-16
Identity = 34/82 (41.46%), Postives = 58/82 (70.73%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEY 371
            +E+RKYL+++G+ D L KVL G+Y+EPEKP  ALE+++ +L    P+ P++E +K+ + EL  R   ++ +N+EL  K+ +Y
Sbjct:   12 EEFRKYLEKAGVLDALTKVLVGLYEEPEKPNNALEFLKQHLGTAGPDAPDVEAMKVEITELRTRVEQLEAENQELREKVQQY 93          
BLAST of c-Myc-binding protein vs. TrEMBL
Match: A0A267DXN0 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig003992g1 PE=4 SV=1)

HSP 1 Score: 75.485 bits (184), Expect = 5.296e-15
Identity = 33/82 (40.24%), Postives = 58/82 (70.73%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEY 371
            +E+RKYL+++G+ D L KVL G+Y+EPEKP  ALE+++ +L    P+ P++E +K+ + EL  R   ++ +N+EL  ++ +Y
Sbjct:   12 EEFRKYLEKAGVLDALTKVLVGLYEEPEKPNNALEFLKLHLGTAGPDAPDVEAMKVEITELRTRKEQLEAENQELRGRLQQY 93          
BLAST of c-Myc-binding protein vs. TrEMBL
Match: F6PWR0 (c-Myc-binding protein OS=Ciona intestinalis OX=7719 GN=LOC100180468 PE=4 SV=2)

HSP 1 Score: 74.3294 bits (181), Expect = 1.264e-14
Identity = 35/82 (42.68%), Postives = 57/82 (69.51%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEY 371
            +E+RKYL+++G+ D L KVL  +Y+EPEKP  ALE++ ++LS D P  P++E LK+ V EL+ +   +  +N EL  ++ +Y
Sbjct:   12 EEFRKYLEKAGVIDALTKVLVNLYEEPEKPNNALEFLNHHLSGDGPETPDVEALKVDVIELKAKVSQLTDENIELKTRLEKY 93          
BLAST of c-Myc-binding protein vs. TrEMBL
Match: A0A3P9MIN5 (Uncharacterized protein OS=Oryzias latipes OX=8090 PE=4 SV=1)

HSP 1 Score: 72.7886 bits (177), Expect = 4.580e-14
Identity = 32/88 (36.36%), Postives = 59/88 (67.05%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEYKSNDEN 389
            +++R+YL+++G+ D+L  VL  +Y++PEKP  ALE++++NL        ++E L+  V +L  RC  +  +N+EL  K+ +Y+S+ EN
Sbjct:   12 EQFRRYLEKAGVVDSLTSVLVSLYEKPEKPTNALEFVKHNLGAVGQTSEDVEALQQEVIDLRQRCARLAEENEELKAKLQQYESSSEN 99          
BLAST of c-Myc-binding protein vs. TrEMBL
Match: A0A3B3IMQ5 (Uncharacterized protein OS=Oryzias latipes OX=8090 GN=LOC101175507 PE=4 SV=1)

HSP 1 Score: 72.4034 bits (176), Expect = 8.762e-14
Identity = 32/88 (36.36%), Postives = 58/88 (65.91%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEYKSNDEN 389
            +++R+YL+++G+ D+L  VL  +Y++PEKP  ALE+++ NL        ++E L+  V +L  RC  +  +N+EL  K+ +Y+S+ EN
Sbjct:   12 EQFRRYLEKAGVVDSLTSVLVSLYEKPEKPTNALEFVKQNLGAVGQTSEDVEALQQEVIDLRQRCARLAEENEELKAKLQQYESSSEN 99          
BLAST of c-Myc-binding protein vs. Ensembl Cavefish
Match: mycbp (MYC binding protein [Source:NCBI gene;Acc:111197019])

HSP 1 Score: 55.4546 bits (132), Expect = 9.382e-11
Identity = 27/83 (32.53%), Postives = 56/83 (67.47%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEYK 374
            +++R+YL+++G+ D+L  VL  +Y+E +KP  ALE+IR +LS   P+  ++E L + + EL+ +   +  +N++L  ++ +Y+
Sbjct:   12 EQFRRYLEKAGVLDSLTNVLVALYEETDKPNNALEFIRLHLSTGEPDSGDVETLCLELTELQQKYDALLEENRDLKNRLLQYE 94          
BLAST of c-Myc-binding protein vs. Ensembl Cavefish
Match: mycbp (MYC binding protein [Source:NCBI gene;Acc:111197019])

HSP 1 Score: 55.4546 bits (132), Expect = 9.596e-11
Identity = 27/83 (32.53%), Postives = 56/83 (67.47%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEYK 374
            +++R+YL+++G+ D+L  VL  +Y+E +KP  ALE+IR +LS   P+  ++E L + + EL+ +   +  +N++L  ++ +Y+
Sbjct:   13 EQFRRYLEKAGVLDSLTNVLVALYEETDKPNNALEFIRLHLSTGEPDSGDVETLCLELTELQQKYDALLEENRDLKNRLLQYE 95          
BLAST of c-Myc-binding protein vs. Ensembl Nematostella
Match: EDO42036 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2N6])

HSP 1 Score: 67.0106 bits (162), Expect = 1.384e-15
Identity = 32/90 (35.56%), Postives = 57/90 (63.33%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEYK-SNDENV 392
            +E+RKYL+++G+ D+L KVL  +Y+EPEKP  AL++++ +L    P   +++ LK+ V EL  +   +  +N +L  ++  Y+   DE V
Sbjct:   13 EEFRKYLEKAGVLDSLTKVLVNLYEEPEKPHNALDFVKQHLHGGAPETADVDALKLEVSELRQKVEQLTAENTDLKQRLQTYEPQADEEV 102          
BLAST of c-Myc-binding protein vs. Ensembl Medaka
Match: ENSORLT00000043049.1 (c-Myc-binding protein [Source:NCBI gene;Acc:101175507])

HSP 1 Score: 72.4034 bits (176), Expect = 3.298e-17
Identity = 32/88 (36.36%), Postives = 58/88 (65.91%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEYKSNDEN 389
            +++R+YL+++G+ D+L  VL  +Y++PEKP  ALE+++ NL        ++E L+  V +L  RC  +  +N+EL  K+ +Y+S+ EN
Sbjct:   12 EQFRRYLEKAGVVDSLTSVLVSLYEKPEKPTNALEFVKQNLGAVGQTSEDVEALQQEVIDLRQRCARLAEENEELKAKLQQYESSSEN 99          
BLAST of c-Myc-binding protein vs. Ensembl Medaka
Match: ENSORLT00000034494.1 (c-Myc-binding protein [Source:NCBI gene;Acc:101175507])

HSP 1 Score: 63.5438 bits (153), Expect = 5.811e-14
Identity = 28/79 (35.44%), Postives = 51/79 (64.56%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKI 362
            +++R+YL+++G+ D+L  VL  +Y++PEKP  ALE+++ NL        ++E L+  V +L  RC  +  +N+EL  K+
Sbjct:   12 EQFRRYLEKAGVVDSLTSVLVSLYEKPEKPTNALEFVKQNLGAVGQTSEDVEALQQEVIDLRQRCARLAEENEELKAKV 90          
BLAST of c-Myc-binding protein vs. Ensembl Medaka
Match: mycbp (c-Myc-binding protein [Source:NCBI gene;Acc:101171593])

HSP 1 Score: 60.8474 bits (146), Expect = 6.750e-13
Identity = 27/85 (31.76%), Postives = 56/85 (65.88%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEYKSN 380
            +++R+YL++SG+ D L  +L  +Y+EPEKP  AL++I+  L    P   + E L++ + +L+ +C  +  +N+EL  K+ +++++
Sbjct:    6 EQFRRYLEKSGVLDTLTSILVALYEEPEKPNNALDFIKLQLGAAGPEPADAEALRMELADLQQKCNLLMKENEELRNKLMQFETS 90          
BLAST of c-Myc-binding protein vs. Ensembl Medaka
Match: mycbp (c-Myc-binding protein [Source:NCBI gene;Acc:101171593])

HSP 1 Score: 60.8474 bits (146), Expect = 7.554e-13
Identity = 27/85 (31.76%), Postives = 56/85 (65.88%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEYKSN 380
            +++R+YL++SG+ D L  +L  +Y+EPEKP  AL++I+  L    P   + E L++ + +L+ +C  +  +N+EL  K+ +++++
Sbjct:    8 EQFRRYLEKSGVLDTLTSILVALYEEPEKPNNALDFIKLQLGAAGPEPADAEALRMELADLQQKCNLLMKENEELRNKLMQFETS 92          
BLAST of c-Myc-binding protein vs. Planmine SMEST
Match: SMESG000006427.1 (SMESG000006427.1)

HSP 1 Score: 198.364 bits (503), Expect = 4.729e-67
Identity = 100/100 (100.00%), Postives = 100/100 (100.00%), Query Frame = 3
Query:   96 MNSEQLYIRIQEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEYKSNDENVV 395
            MNSEQLYIRIQEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEYKSNDENVV
Sbjct:    1 MNSEQLYIRIQEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNNLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEYKSNDENVV 100          
BLAST of c-Myc-binding protein vs. Planmine SMEST
Match: SMESG000001466.1 (SMESG000001466.1)

HSP 1 Score: 58.5362 bits (140), Expect = 6.172e-12
Identity = 31/87 (35.63%), Postives = 55/87 (63.22%), Query Frame = 3
Query:  126 QEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRN--NLSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEYKSN 380
            +E++KYL+R G+ D L KVL  +Y+EPEKP  ALE++RN   ++Q      ++E +K ++ EL+ +   +  +N+ L  ++ E + N
Sbjct:    8 EEFKKYLERCGVLDILTKVLVELYEEPEKPSNALEFLRNQIGVTQSSDENVDVESMKSTISELQQQLEQLTTENETLKSQLEELQKN 94          
The following BLAST results are available for this feature:
BLAST of c-Myc-binding protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
MYCBP1.022e-1436.59MYC binding protein [Source:HGNC Symbol;Acc:HGNC:7... [more]
AL139260.31.867e-1436.59novel protein[more]
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BLAST of c-Myc-binding protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of c-Myc-binding protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
CG45467.352e-736.62gene:FBgn0038373 transcript:FBtr0083184[more]
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BLAST of c-Myc-binding protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mycbp1.249e-828.92MYC binding protein [Source:ZFIN;Acc:ZDB-GENE-0603... [more]
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BLAST of c-Myc-binding protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
adrb23.188e-1434.15adrenoceptor beta 2 [Source:Xenbase;Acc:XB-GENE-49... [more]
adrb23.368e-1434.15adrenoceptor beta 2 [Source:Xenbase;Acc:XB-GENE-49... [more]
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BLAST of c-Myc-binding protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Mycbp1.325e-1436.59MYC binding protein [Source:MGI Symbol;Acc:MGI:189... [more]
Mycbp5.857e-1340.98MYC binding protein [Source:MGI Symbol;Acc:MGI:189... [more]
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BLAST of c-Myc-binding protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q99417|MYCBP_HUMAN4.909e-1436.59c-Myc-binding protein OS=Homo sapiens OX=9606 GN=M... [more]
sp|Q5R7A8|MYCBP_PONAB5.527e-1436.59c-Myc-binding protein OS=Pongo abelii OX=9601 GN=M... [more]
sp|Q2TBP7|MYCBP_BOVIN5.709e-1436.59c-Myc-binding protein OS=Bos taurus OX=9913 GN=MYC... [more]
sp|Q9EQS3|MYCBP_MOUSE9.270e-1436.59c-Myc-binding protein OS=Mus musculus OX=10090 GN=... [more]
sp|Q54I57|MYCBP_DICDI3.114e-939.47c-Myc-binding protein homolog OS=Dictyostelium dis... [more]
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BLAST of c-Myc-binding protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1I8GVQ62.107e-1641.46Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267DXN05.296e-1540.24Uncharacterized protein OS=Macrostomum lignano OX=... [more]
F6PWR01.264e-1442.68c-Myc-binding protein OS=Ciona intestinalis OX=771... [more]
A0A3P9MIN54.580e-1436.36Uncharacterized protein OS=Oryzias latipes OX=8090... [more]
A0A3B3IMQ58.762e-1436.36Uncharacterized protein OS=Oryzias latipes OX=8090... [more]
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BLAST of c-Myc-binding protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
mycbp9.382e-1132.53MYC binding protein [Source:NCBI gene;Acc:11119701... [more]
mycbp9.596e-1132.53MYC binding protein [Source:NCBI gene;Acc:11119701... [more]
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BLAST of c-Myc-binding protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of c-Myc-binding protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of c-Myc-binding protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO420361.384e-1535.56Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of c-Myc-binding protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ENSORLT00000043049.13.298e-1736.36c-Myc-binding protein [Source:NCBI gene;Acc:101175... [more]
ENSORLT00000034494.15.811e-1435.44c-Myc-binding protein [Source:NCBI gene;Acc:101175... [more]
mycbp6.750e-1331.76c-Myc-binding protein [Source:NCBI gene;Acc:101171... [more]
mycbp7.554e-1331.76c-Myc-binding protein [Source:NCBI gene;Acc:101171... [more]
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BLAST of c-Myc-binding protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000006427.14.729e-67100.00SMESG000006427.1[more]
SMESG000001466.16.172e-1235.63SMESG000001466.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30024869 ID=SMED30024869|Name=c-Myc-binding protein|organism=Schmidtea mediterranea sexual|type=transcript|length=405bp
TTCAAGGTCAAAACCAAATTTTGTGTTTCCTTAGCAACTGAAGAATTCAT
AAATCAAGAATTGTCAAATATCTACAGAAATTTTAAACCAGAATTATGAA
TTCAGAACAATTATATATTCGCATACAGGAATATAGAAAATATTTAGATA
GAAGTGGAATTACTGATAATTTATTCAAAGTATTGACTGGTATTTATCAA
GAGCCCGAAAAACCACTAGAAGCCCTTGAATATATAAGAAACAATTTATC
ACAAGATCCTCCAAATATTCCAGAATTAGAAGAACTTAAAATATCGGTTA
AAGAATTGGAAATGCGGTGTTTAGATATGCAAATGAAAAATAAAGAATTA
CTATTAAAAATATCTGAATATAAATCAAACGATGAAAATGTTGTTTAAAT
ATAAT
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protein sequence of SMED30024869-orf-1

>SMED30024869-orf-1 ID=SMED30024869-orf-1|Name=SMED30024869-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=101bp
MNSEQLYIRIQEYRKYLDRSGITDNLFKVLTGIYQEPEKPLEALEYIRNN
LSQDPPNIPELEELKISVKELEMRCLDMQMKNKELLLKISEYKSNDENVV
*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0045880positive regulation of smoothened signaling pathway
GO:1903508positive regulation of nucleic acid-templated transcription
GO:0006351transcription, DNA-templated
GO:0006355regulation of transcription, DNA-templated
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000034epidermis
PLANA:0000099neuron
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR026060AMY1
Vocabulary: molecular function
TermDefinition
GO:0003713transcription coactivator activity
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005737cytoplasm
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 61..88
NoneNo IPR availablePRINTSPR02028CMYCBINDINGPcoord: 7..17
score: 38.08
coord: 31..45
score: 42.61
coord: 17..31
score: 45.6
IPR026060Associate of Myc 1PANTHERPTHR13168ASSOCIATE OF C-MYC AMY-1coord: 11..97