Superoxide dismutase [Cu-Zn]

Overview
NameSuperoxide dismutase [Cu-Zn]
Smed IDSMED30024804
Length (bp)522
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Superoxide dismutase [Cu-Zn] (SMED30024804) t-SNE clustered cells

Violin plots show distribution of expression levels for Superoxide dismutase [Cu-Zn] (SMED30024804) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Superoxide dismutase [Cu-Zn] (SMED30024804) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Superoxide dismutase [Cu-Zn] (SMED30024804) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30024804

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30024804SMESG000020880.1 dd_Smed_v4_519_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30024804SMESG000020880.1 dd_Smed_v4_519_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30024804SMESG000020880.1 dd_Smed_v4_519_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30024804SMESG000020880.1 dd_Smed_v4_519_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30024804SMESG000020880.1 Contig15891newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30024804SMESG000020880.1 Contig15891uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Human
Match: SOD1 (superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179])

HSP 1 Score: 186.037 bits (471), Expect = 1.783e-60
Identity = 93/154 (60.39%), Postives = 110/154 (71.43%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            M   AVCVLK +  + G + F Q ++ GPV++   I GLT G HGFH+HEFGDNT GC SAG H+NP  + HG P DEERHVGDLGNVTAD  G   V++ D V+SL G   IIGR+LVVHE  DDLGKGG+E S  TGNAG RLACGV+GI +
Sbjct:    1 MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ 154
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Human
Match: SOD1 (superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179])

HSP 1 Score: 166.777 bits (421), Expect = 4.157e-53
Identity = 83/132 (62.88%), Postives = 99/132 (75.00%), Query Frame = 2 
Query:   89 QSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            ++++ GPV++   I GLT G HGFH+HEFGDNT GC SAG H+NP  + HG P DEERHVGDLGNVTAD  G   V++ D V+SL G   IIGR+LVVHE  DDLGKGG+E S  TGNAG RLACGV+GI +
Sbjct:    4 KAESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ 135
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Human
Match: CCS (copper chaperone for superoxide dismutase [Source:HGNC Symbol;Acc:HGNC:1613])

HSP 1 Score: 140.198 bits (352), Expect = 3.233e-41
Identity = 71/148 (47.97%), Postives = 94/148 (63.51%), Query Frame = 2 
Query:   35 AVCVLKNENNLNGTVKFMQSDAGGPVEIDVE--ISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVV 472
            AV +L     + G V+F+Q     P    +E  I GL PG HG H+H++GD TN C S G H+NP G +HG P D +RH GDLGNV ADA G+    + D+ + +     +IGRSL++ E EDDLG+GGH  SK TGN+G RLACG++
Sbjct:   70 AVAILGGPGTVQGVVRFLQLT---PERCLIEGTIDGLEPGLHGLHVHQYGDLTNNCNSCGNHFNPDGASHGGPQDSDRHRGDLGNVRADADGRAIFRMEDEQLKV---WDVIGRSLIIDEGEDDLGRGGHPLSKITGNSGERLACGII 211
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Human
Match: CCS (copper chaperone for superoxide dismutase [Source:HGNC Symbol;Acc:HGNC:1613])

HSP 1 Score: 140.584 bits (353), Expect = 3.920e-41
Identity = 71/148 (47.97%), Postives = 94/148 (63.51%), Query Frame = 2 
Query:   35 AVCVLKNENNLNGTVKFMQSDAGGPVEIDVE--ISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVV 472
            AV +L     + G V+F+Q     P    +E  I GL PG HG H+H++GD TN C S G H+NP G +HG P D +RH GDLGNV ADA G+    + D+ + +     +IGRSL++ E EDDLG+GGH  SK TGN+G RLACG++
Sbjct:   89 AVAILGGPGTVQGVVRFLQLT---PERCLIEGTIDGLEPGLHGLHVHQYGDLTNNCNSCGNHFNPDGASHGGPQDSDRHRGDLGNVRADADGRAIFRMEDEQLKV---WDVIGRSLIIDEGEDDLGRGGHPLSKITGNSGERLACGII 230
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Human
Match: SOD3 (superoxide dismutase 3 [Source:HGNC Symbol;Acc:HGNC:11181])

HSP 1 Score: 96.2857 bits (238), Expect = 2.776e-24
Identity = 60/162 (37.04%), Postives = 79/162 (48.77%), Query Frame = 2 
Query:   26 TVHAVCVLKNENNLN-------GTVKFMQSDAGGPVEIDVEISGLT----PGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGI 478
             +HA C ++    L+       G V F Q      ++    + G            H+H+FGD + GC S G HYNP    H       +H GD GN  A   G +         SL GP SI+GR++VVH  EDDLG+GG++ S   GNAG RLAC VVG+
Sbjct:   58 ALHAACQVQPSATLDAAQPRVTGVVLFRQLAPRAKLDAFFALEGFPTEPNSSSRAIHVHQFGDLSQGCESTGPHYNPLAVPH------PQHPGDFGNF-AVRDGSLWRYRAGLAASLAGPHSIVGRAVVVHAGEDDLGRGGNQASVENGNAGRRLACCVVGV 212
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Celegans
Match: sod-1 (Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Swiss-Prot;Acc:P34697])

HSP 1 Score: 169.088 bits (427), Expect = 8.821e-54
Identity = 86/156 (55.13%), Postives = 108/156 (69.23%), Query Frame = 2 
Query:   20 KMTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKG---GHETSKTTGNAGGRLACGVVGI 478
            KM+  AV VL+ E  + GT+   Q        I+ EI GLTPG HGFH+H++GD+TNGCISAG H+NP GKTHG P  E RHVGDLGNV A A G  K+ LTD +++L GP +++GRS+VVH  +DDLG+G     E SK TGNAG R ACGV+ +
Sbjct:   22 KMSNRAVAVLRGET-VTGTIWITQKSENDQAVIEGEIKGLTPGLHGFHVHQYGDSTNGCISAGPHFNPFGKTHGGPKSEIRHVGDLGNVEAGADGVAKIKLTDTLVTLYGPNTVVGRSMVVHAGQDDLGEGVGDKAEESKKTGNAGARAACGVIAL 176
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Celegans
Match: sod-1 (Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Swiss-Prot;Acc:P34697])

HSP 1 Score: 166.007 bits (419), Expect = 6.953e-53
Identity = 85/155 (54.84%), Postives = 107/155 (69.03%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKG---GHETSKTTGNAGGRLACGVVGI 478
            M+  AV VL+ E  + GT+   Q        I+ EI GLTPG HGFH+H++GD+TNGCISAG H+NP GKTHG P  E RHVGDLGNV A A G  K+ LTD +++L GP +++GRS+VVH  +DDLG+G     E SK TGNAG R ACGV+ +
Sbjct:    1 MSNRAVAVLRGET-VTGTIWITQKSENDQAVIEGEIKGLTPGLHGFHVHQYGDSTNGCISAGPHFNPFGKTHGGPKSEIRHVGDLGNVEAGADGVAKIKLTDTLVTLYGPNTVVGRSMVVHAGQDDLGEGVGDKAEESKKTGNAGARAACGVIAL 154
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Celegans
Match: sod-1 (Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Swiss-Prot;Acc:P34697])

HSP 1 Score: 166.007 bits (419), Expect = 6.953e-53
Identity = 85/155 (54.84%), Postives = 107/155 (69.03%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKG---GHETSKTTGNAGGRLACGVVGI 478
            M+  AV VL+ E  + GT+   Q        I+ EI GLTPG HGFH+H++GD+TNGCISAG H+NP GKTHG P  E RHVGDLGNV A A G  K+ LTD +++L GP +++GRS+VVH  +DDLG+G     E SK TGNAG R ACGV+ +
Sbjct:    1 MSNRAVAVLRGET-VTGTIWITQKSENDQAVIEGEIKGLTPGLHGFHVHQYGDSTNGCISAGPHFNPFGKTHGGPKSEIRHVGDLGNVEAGADGVAKIKLTDTLVTLYGPNTVVGRSMVVHAGQDDLGEGVGDKAEESKKTGNAGARAACGVIAL 154
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Celegans
Match: sod-4 (Extracellular superoxide dismutase [Cu-Zn] [Source:UniProtKB/Swiss-Prot;Acc:P34461])

HSP 1 Score: 166.392 bits (420), Expect = 3.048e-52
Identity = 82/145 (56.55%), Postives = 104/145 (71.72%), Query Frame = 2 
Query:   50 KNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            K    L GT+ F QS  G  ++++  +SGL  GKHGFHIHE GD  NGC+SAGGHYNPH  +HGAP D  RH+GDLGN+ + ASG   ++++D + SL G  SIIGRS+V+HE  DDLG+G  + SKTTGNAG RLACG +GI +
Sbjct:   35 KIPTELIGTIDFDQS--GSFLKLNGSVSGLAAGKHGFHIHEKGDTGNGCLSAGGHYNPHKLSHGAPDDSNRHIGDLGNIESPASGDTLISVSDSLASLSGQYSIIGRSVVIHEKTDDLGRGTSDQSKTTGNAGSRLACGTIGIVE 177
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Celegans
Match: sod-4 (Extracellular superoxide dismutase [Cu-Zn] [Source:UniProtKB/Swiss-Prot;Acc:P34461])

HSP 1 Score: 163.696 bits (413), Expect = 1.079e-51
Identity = 81/142 (57.04%), Postives = 102/142 (71.83%), Query Frame = 2 
Query:   50 KNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVG 475
            K    L GT+ F QS  G  ++++  +SGL  GKHGFHIHE GD  NGC+SAGGHYNPH  +HGAP D  RH+GDLGN+ + ASG   ++++D + SL G  SIIGRS+V+HE  DDLG+G  + SKTTGNAG RLACG +G
Sbjct:   35 KIPTELIGTIDFDQS--GSFLKLNGSVSGLAAGKHGFHIHEKGDTGNGCLSAGGHYNPHKLSHGAPDDSNRHIGDLGNIESPASGDTLISVSDSLASLSGQYSIIGRSVVIHEKTDDLGRGTSDQSKTTGNAGSRLACGTIG 174
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Fly
Match: Sod1 (gene:FBgn0003462 transcript:FBtr0076229)

HSP 1 Score: 181.8 bits (460), Expect = 3.927e-59
Identity = 89/154 (57.79%), Postives = 112/154 (72.73%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            M V AVCV+  +    GTV F Q  +G PV++  E+ GL  G HGFH+HEFGDNTNGC+S+G H+NP+GK HGAP DE RH+GDLGN+ A      KV +TD  ++L G  SIIGR++VVH + DDLG+GGHE SK+TGNAG R+ CGV+GI K
Sbjct:    1 MVVKAVCVINGD--AKGTVFFEQESSGTPVKVSGEVCGLAKGLHGFHVHEFGDNTNGCMSSGPHFNPYGKEHGAPVDENRHLGDLGNIEATGDCPTKVNITDSKITLFGADSIIGRTVVVHADADDLGQGGHELSKSTGNAGARIGCGVIGIAK 152
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Fly
Match: Sod3 (gene:FBgn0033631 transcript:FBtr0089938)

HSP 1 Score: 167.548 bits (423), Expect = 3.669e-53
Identity = 87/157 (55.41%), Postives = 106/157 (67.52%), Query Frame = 2 
Query:   23 MTVHAVCVL-----KNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGI 478
            M + A+  L      +   + G V F Q+D G  V + V++ GL  GKHGFHIHE GD TNGCIS G HYNP    HG P  E RHVGDLGN+ A+++G + VT TD+V++L G L IIGR +VVHE EDDLG G H  SK TGNAGGR+ACGV+GI
Sbjct:   24 MPIQAIAYLIGPVQSDNTQVKGNVTFTQNDCGQNVHVRVQLEGLKEGKHGFHIHEKGDLTNGCISMGAHYNPDKVDHGGPDHEVRHVGDLGNLEANSTGIIDVTYTDQVITLTGKLGIIGRGVVVHELEDDLGLGNHTDSKKTGNAGGRIACGVIGI 180
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Fly
Match: Sod3 (gene:FBgn0033631 transcript:FBtr0433531)

HSP 1 Score: 167.548 bits (423), Expect = 3.669e-53
Identity = 87/157 (55.41%), Postives = 106/157 (67.52%), Query Frame = 2 
Query:   23 MTVHAVCVL-----KNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGI 478
            M + A+  L      +   + G V F Q+D G  V + V++ GL  GKHGFHIHE GD TNGCIS G HYNP    HG P  E RHVGDLGN+ A+++G + VT TD+V++L G L IIGR +VVHE EDDLG G H  SK TGNAGGR+ACGV+GI
Sbjct:   24 MPIQAIAYLIGPVQSDNTQVKGNVTFTQNDCGQNVHVRVQLEGLKEGKHGFHIHEKGDLTNGCISMGAHYNPDKVDHGGPDHEVRHVGDLGNLEANSTGIIDVTYTDQVITLTGKLGIIGRGVVVHELEDDLGLGNHTDSKKTGNAGGRIACGVIGI 180
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Fly
Match: Sod3 (gene:FBgn0033631 transcript:FBtr0089939)

HSP 1 Score: 167.548 bits (423), Expect = 3.669e-53
Identity = 87/157 (55.41%), Postives = 106/157 (67.52%), Query Frame = 2 
Query:   23 MTVHAVCVL-----KNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGI 478
            M + A+  L      +   + G V F Q+D G  V + V++ GL  GKHGFHIHE GD TNGCIS G HYNP    HG P  E RHVGDLGN+ A+++G + VT TD+V++L G L IIGR +VVHE EDDLG G H  SK TGNAGGR+ACGV+GI
Sbjct:   24 MPIQAIAYLIGPVQSDNTQVKGNVTFTQNDCGQNVHVRVQLEGLKEGKHGFHIHEKGDLTNGCISMGAHYNPDKVDHGGPDHEVRHVGDLGNLEANSTGIIDVTYTDQVITLTGKLGIIGRGVVVHELEDDLGLGNHTDSKKTGNAGGRIACGVIGI 180
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Fly
Match: Sod3 (gene:FBgn0033631 transcript:FBtr0110897)

HSP 1 Score: 168.318 bits (425), Expect = 6.861e-53
Identity = 87/157 (55.41%), Postives = 106/157 (67.52%), Query Frame = 2 
Query:   23 MTVHAVCVL-----KNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGI 478
            M + A+  L      +   + G V F Q+D G  V + V++ GL  GKHGFHIHE GD TNGCIS G HYNP    HG P  E RHVGDLGN+ A+++G + VT TD+V++L G L IIGR +VVHE EDDLG G H  SK TGNAGGR+ACGV+GI
Sbjct:   24 MPIQAIAYLIGPVQSDNTQVKGNVTFTQNDCGQNVHVRVQLEGLKEGKHGFHIHEKGDLTNGCISMGAHYNPDKVDHGGPDHEVRHVGDLGNLEANSTGIIDVTYTDQVITLTGKLGIIGRGVVVHELEDDLGLGNHTDSKKTGNAGGRIACGVIGI 180
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Zebrafish
Match: sod1 (superoxide dismutase 1, soluble [Source:NCBI gene;Acc:30553])

HSP 1 Score: 203.756 bits (517), Expect = 1.268e-67
Identity = 101/154 (65.58%), Postives = 118/154 (76.62%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            M   AVCVLK    + GTV F Q     PV++  EI+GLTPGKHGFH+H FGDNTNGCISAG H+NPH KTHG P D  RHVGDLGNVTADASG  K+ + D +++L G  SIIGR++V+HE EDDLGKGG+E S  TGNAGGRLACGV+GIT+
Sbjct:    1 MVNKAVCVLKGTGEVTGTVYFNQEGEKKPVKVTGEITGLTPGKHGFHVHAFGDNTNGCISAGPHFNPHDKTHGGPTDSVRHVGDLGNVTADASGVAKIEIEDAMLTLSGQHSIIGRTMVIHEKEDDLGKGGNEESLKTGNAGGRLACGVIGITQ 154
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Zebrafish
Match: ccs (copper chaperone for superoxide dismutase [Source:ZFIN;Acc:ZDB-GENE-050417-322])

HSP 1 Score: 140.198 bits (352), Expect = 3.049e-41
Identity = 73/147 (49.66%), Postives = 91/147 (61.90%), Query Frame = 2 
Query:   35 AVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVG 475
            AV +L     + G V+F+Q      + ID  I GL+PG HG H+HE GD T  C S G H+NP  K HGAP D +RHVGDLGN++A   G+    L D   S +    +IGRSLVV   EDDLG+G H  SKTTGN+G RLACG++ 
Sbjct:   83 AVAMLSGAGLVQGVVRFLQLSQDRCL-IDGTIDGLSPGAHGLHVHELGDLTQDCRSCGDHFNPFRKQHGAPQDSDRHVGDLGNISAGPDGRASFRLED---SQIKVWDVIGRSLVVDSGEDDLGRGNHPLSKTTGNSGERLACGIIA 225
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Zebrafish
Match: ccs (copper chaperone for superoxide dismutase [Source:ZFIN;Acc:ZDB-GENE-050417-322])

HSP 1 Score: 139.428 bits (350), Expect = 7.534e-41
Identity = 73/147 (49.66%), Postives = 91/147 (61.90%), Query Frame = 2 
Query:   35 AVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVG 475
            AV +L     + G V+F+Q      + ID  I GL+PG HG H+HE GD T  C S G H+NP  K HGAP D +RHVGDLGN++A   G+    L D   S +    +IGRSLVV   EDDLG+G H  SKTTGN+G RLACG++ 
Sbjct:   83 AVAMLSGAGLVQGVVRFLQLSHDRCL-IDGTIDGLSPGAHGLHVHELGDLTQDCRSCGDHFNPFRKQHGAPQDSDRHVGDLGNISAGPDGRASFRLED---SQIKVWDVIGRSLVVDSGEDDLGRGNHPLSKTTGNSGERLACGIIA 225
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Zebrafish
Match: sod3a (superoxide dismutase 3, extracellular a [Source:ZFIN;Acc:ZDB-GENE-050309-208])

HSP 1 Score: 103.219 bits (256), Expect = 1.731e-27
Identity = 63/166 (37.95%), Postives = 85/166 (51.20%), Query Frame = 2 
Query:   17 FKMTVHAVCVLKNENNLN-------GTVKFMQSDAGGPVEIDVEISGLTPGK---HGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            F  T++A C +    NL        G V F Q    G  E+ + + G           HIH++GD + GC++AG HYNP    H        H GD+GN      G ++  L    + L G  S++GR++VVHE EDDLG G  E SK +GNAG R+A  V+GITK
Sbjct:   38 FNNTIYATCEVSPIPNLPAGQPEIFGQVLFRQVFPNGTAEVKINLRGFPETDNQVRAIHIHQYGDLSQGCVTAGPHYNPQDVPH------PNHPGDMGNFMP-KQGLIRRFLKLPEVKLFGGQSVLGRAVVVHEKEDDLGMGADEESKRSGNAGRRIAGCVIGITK 196
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Zebrafish
Match: sod3b (superoxide dismutase 3, extracellular b [Source:ZFIN;Acc:ZDB-GENE-030131-8743])

HSP 1 Score: 102.064 bits (253), Expect = 3.393e-27
Identity = 62/161 (38.51%), Postives = 87/161 (54.04%), Query Frame = 2 
Query:   26 TVHAVCVLKNENNLN-------GTVKFMQSDAGGPVEIDVEISGL---TPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGI 478
            ++ AVC ++    L        G + F QS     + +   + GL   +      HIHE+GD + GC S GGHYNP    H       +H GD GN     + K++ +L     +L G LSI+GRS+V+HE +DDLG+GG+  S   GNAGGRLAC V+G+
Sbjct:   35 SLQAVCRMQPNTRLEPGMPRVYGHILFRQSGPKEKLSVTFRLYGLPADSQQPRAMHIHEYGDLSRGCDSTGGHYNPLNVNH------PQHPGDFGNFVP-VNKKIRQSLESPA-TLFGKLSIVGRSVVIHEGKDDLGRGGNVGSLLNGNAGGRLACCVIGL 187
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Xenopus
Match: sod1 (superoxide dismutase 1 [Source:NCBI gene;Acc:549006])

HSP 1 Score: 182.956 bits (463), Expect = 2.721e-59
Identity = 98/152 (64.47%), Postives = 112/152 (73.68%), Query Frame = 2 
Query:   29 VHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            V AVCVL    ++ G V F Q D G PV ++ +I GLT GKHGFHIHEFGDNTNGCISAG H+NP  KTHGAP D  RHVGDLGNVTA   G  +  LTD ++SL G  SIIGR  VVHE EDDLGKGG++ S  TGNAGGRLACGV+G+ +
Sbjct:    2 VRAVCVLAGSGDVKGVVHFQQQDEG-PVTVEGKIYGLTDGKHGFHIHEFGDNTNGCISAGPHFNPESKTHGAPEDAVRHVGDLGNVTA-KDGVAEFKLTDSLISLKGNHSIIGRCAVVHEKEDDLGKGGNDESLKTGNAGGRLACGVIGLCQ 151
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Xenopus
Match: ccs (copper chaperone for superoxide dismutase [Source:NCBI gene;Acc:496429])

HSP 1 Score: 139.813 bits (351), Expect = 9.261e-41
Identity = 71/147 (48.30%), Postives = 97/147 (65.99%), Query Frame = 2 
Query:   35 AVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVG 475
            AV ++  E ++ G V+F+Q+     + I+  + GL+PG HG H+HEFGD +NGC S G HYNPH  +HG P +++RHVGDLGN+ A  +G+    L D+ + +     IIGRSLVV E EDDLG G H  SK TGN+G RLA G++ 
Sbjct:   88 AVAMMSGEGSIQGVVRFIQTSENTCI-IEGTLDGLSPGLHGIHVHEFGDISNGCESCGEHYNPHRNSHGGPGEDDRHVGDLGNIFAADNGRASFRLMDERLKV---YDIIGRSLVVDEGEDDLGHGCHPLSKITGNSGRRLASGIIA 230
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Xenopus
Match: ccs (copper chaperone for superoxide dismutase [Source:NCBI gene;Acc:496429])

HSP 1 Score: 106.301 bits (264), Expect = 3.382e-28
Identity = 60/147 (40.82%), Postives = 80/147 (54.42%), Query Frame = 2 
Query:   35 AVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVG 475
            AV ++  E ++ G V+F+Q+     + I+  + GL+PG HG H+HEFGD +NGC S G HYNPH  +HG P +++R                                IIGRSLVV E EDDLG G H  SK TGN+G RLA G++ 
Sbjct:   88 AVAMMSGEGSIQGVVRFIQTSENTCI-IEGTLDGLSPGLHGIHVHEFGDISNGCESCGEHYNPHRNSHGGPGEDDR-----------------------------VYDIIGRSLVVDEGEDDLGHGCHPLSKITGNSGRRLASGIIA 204
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Xenopus
Match: sh3rf2 (SH3 domain containing ring finger 2 [Source:Xenbase;Acc:XB-GENE-5763588])

HSP 1 Score: 105.916 bits (263), Expect = 3.824e-28
Identity = 63/160 (39.38%), Postives = 82/160 (51.25%), Query Frame = 2 
Query:   29 VHAVCVLK-------NENNLNGTVKFMQSDAGGPVEIDVEISGL----TPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVG 475
             +A C L        +E  + G V F Q    G +E   ++ G            HIH +GD TNGC SAGGHYNP         D  +H GD GN      GK++    +   +L GP S+IGRS+VVH+  DDLGKG ++ S   GNAG RLAC ++G
Sbjct:   58 AYATCSLSPSSKLEPSEVKVTGLVLFKQVFPSGTLEAIFDLEGFPTDANQSARAIHIHTYGDLTNGCDSAGGHYNPMS------VDHPQHPGDFGNFRV-RDGKIQKFFANLDATLFGPFSVIGRSVVVHKQADDLGKGNNQASLENGNAGKRLACCIIG 210
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Xenopus
Match: ccs (copper chaperone for superoxide dismutase [Source:NCBI gene;Acc:496429])

HSP 1 Score: 93.9745 bits (232), Expect = 2.528e-23
Identity = 48/92 (52.17%), Postives = 61/92 (66.30%), Query Frame = 2 
Query:  200 SAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVG 475
            S G HYNPH  +HG P +++RHVGDLGN+ A  +G+    L D+ + +     IIGRSLVV E EDDLG G H  SK TGN+G RLA G++ 
Sbjct:  134 SCGEHYNPHRNSHGGPGEDDRHVGDLGNIFAADNGRASFRLMDERLKVY---DIIGRSLVVDEGEDDLGHGCHPLSKITGNSGRRLASGIIA 222
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Mouse
Match: Sod1 (superoxide dismutase 1, soluble [Source:MGI Symbol;Acc:MGI:98351])

HSP 1 Score: 194.897 bits (494), Expect = 4.078e-64
Identity = 93/154 (60.39%), Postives = 116/154 (75.32%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            M + AVCVLK +  + GT+ F Q  +G PV +  +I+GLT G+HGFH+H++GDNT GC SAG H+NPH K HG P DEERHVGDLGNVTA   G   V++ D+V+SL G  SIIGR++VVHE +DDLGKGG+E S  TGNAG RLACGV+GI +
Sbjct:    1 MAMKAVCVLKGDGPVQGTIHFEQKASGEPVVLSGQITGLTEGQHGFHVHQYGDNTQGCTSAGPHFNPHSKKHGGPADEERHVGDLGNVTAGKDGVANVSIEDRVISLSGEHSIIGRTMVVHEKQDDLGKGGNEESTKTGNAGSRLACGVIGIAQ 154
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Mouse
Match: Ccs (copper chaperone for superoxide dismutase [Source:MGI Symbol;Acc:MGI:1333783])

HSP 1 Score: 138.658 bits (348), Expect = 5.255e-41
Identity = 70/146 (47.95%), Postives = 96/146 (65.75%), Query Frame = 2 
Query:   35 AVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVV 472
            AV +L+   ++ G V+F+Q  +   + I+  I GL PG HG H+H++GD T  C S G H+NP G +HG P D +RH GDLGNV A+A G+    + DK + +     +IGRSLV+ E EDDLG+GGH  SK TGN+G RLACG++
Sbjct:   43 AVAILEGCGSIQGVVRFLQLSSELCL-IEGTIDGLEPGLHGLHVHQYGDLTRDCNSCGDHFNPDGASHGGPQDTDRHRGDLGNVRAEAGGRATFRIEDKQLKV---WDVIGRSLVIDEGEDDLGRGGHPLSKITGNSGKRLACGII 184
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Mouse
Match: Ccs (copper chaperone for superoxide dismutase [Source:MGI Symbol;Acc:MGI:1333783])

HSP 1 Score: 139.813 bits (351), Expect = 5.841e-41
Identity = 70/146 (47.95%), Postives = 96/146 (65.75%), Query Frame = 2 
Query:   35 AVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVV 472
            AV +L+   ++ G V+F+Q  +   + I+  I GL PG HG H+H++GD T  C S G H+NP G +HG P D +RH GDLGNV A+A G+    + DK + +     +IGRSLV+ E EDDLG+GGH  SK TGN+G RLACG++
Sbjct:   89 AVAILEGCGSIQGVVRFLQLSSELCL-IEGTIDGLEPGLHGLHVHQYGDLTRDCNSCGDHFNPDGASHGGPQDTDRHRGDLGNVRAEAGGRATFRIEDKQLKV---WDVIGRSLVIDEGEDDLGRGGHPLSKITGNSGKRLACGII 230
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Mouse
Match: Ccs (copper chaperone for superoxide dismutase [Source:MGI Symbol;Acc:MGI:1333783])

HSP 1 Score: 139.428 bits (350), Expect = 6.485e-41
Identity = 70/146 (47.95%), Postives = 96/146 (65.75%), Query Frame = 2 
Query:   35 AVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVV 472
            AV +L+   ++ G V+F+Q  +   + I+  I GL PG HG H+H++GD T  C S G H+NP G +HG P D +RH GDLGNV A+A G+    + DK + +     +IGRSLV+ E EDDLG+GGH  SK TGN+G RLACG++
Sbjct:   82 AVAILEGCGSIQGVVRFLQLSSELCL-IEGTIDGLEPGLHGLHVHQYGDLTRDCNSCGDHFNPDGASHGGPQDTDRHRGDLGNVRAEAGGRATFRIEDKQLKV---WDVIGRSLVIDEGEDDLGRGGHPLSKITGNSGKRLACGII 223
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Mouse
Match: Ccs (copper chaperone for superoxide dismutase [Source:MGI Symbol;Acc:MGI:1333783])

HSP 1 Score: 131.724 bits (330), Expect = 2.333e-38
Identity = 63/119 (52.94%), Postives = 81/119 (68.07%), Query Frame = 2 
Query:  116 IDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVV 472
            I+  I GL PG HG H+H++GD T  C S G H+NP G +HG P D +RH GDLGNV A+A G+    + DK + +     +IGRSLV+ E EDDLG+GGH  SK TGN+G RLACG++
Sbjct:   69 IEGTIDGLEPGLHGLHVHQYGDLTRDCNSCGDHFNPDGASHGGPQDTDRHRGDLGNVRAEAGGRATFRIEDKQLKV---WDVIGRSLVIDEGEDDLGRGGHPLSKITGNSGKRLACGII 184
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. UniProt/SwissProt
Match: sp|O73872|SODC_DANRE (Superoxide dismutase [Cu-Zn] OS=Danio rerio OX=7955 GN=sod1 PE=2 SV=1)

HSP 1 Score: 203.756 bits (517), Expect = 9.573e-67
Identity = 101/154 (65.58%), Postives = 118/154 (76.62%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            M   AVCVLK    + GTV F Q     PV++  EI+GLTPGKHGFH+H FGDNTNGCISAG H+NPH KTHG P D  RHVGDLGNVTADASG  K+ + D +++L G  SIIGR++V+HE EDDLGKGG+E S  TGNAGGRLACGV+GIT+
Sbjct:    1 MVNKAVCVLKGTGEVTGTVYFNQEGEKKPVKVTGEITGLTPGKHGFHVHAFGDNTNGCISAGPHFNPHDKTHGGPTDSVRHVGDLGNVTADASGVAKIEIEDAMLTLSGQHSIIGRTMVIHEKEDDLGKGGNEESLKTGNAGGRLACGVIGITQ 154
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. UniProt/SwissProt
Match: sp|P10792|SODCP_PETHY (Superoxide dismutase [Cu-Zn], chloroplastic OS=Petunia hybrida OX=4102 GN=SODCP PE=2 SV=1)

HSP 1 Score: 197.978 bits (502), Expect = 1.261e-63
Identity = 98/158 (62.03%), Postives = 116/158 (73.42%), Query Frame = 2 
Query:    8 LLLFKMTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGIT 481
             ++F  T  AV VLK  +N+ G V   Q D  GP  + V I+GL PG HGFH+HEFGD TNGC+S G H+NP+G THGAP DE RH GDLGN+ A+ASG  + TL D  + L GP S++GR+LVVHE EDDLGKGGHE S TTGNAGGRLACGVVG+T
Sbjct:   61 FIVFAATKKAVAVLKGTSNVEGVVTLTQDD-DGPTTVKVRITGLAPGLHGFHLHEFGDTTNGCMSTGPHFNPNGLTHGAPGDEVRHAGDLGNIEANASGVAEATLVDNQIPLSGPNSVVGRALVVHELEDDLGKGGHELSLTTGNAGGRLACGVVGLT 217
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. UniProt/SwissProt
Match: sp|Q8HXQ0|SODC_MACMU (Superoxide dismutase [Cu-Zn] OS=Macaca mulatta OX=9544 GN=SOD1 PE=2 SV=3)

HSP 1 Score: 195.667 bits (496), Expect = 1.743e-63
Identity = 96/154 (62.34%), Postives = 116/154 (75.32%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            M + AVCVLK ++ + GT+ F Q ++ GPV++   I+GLT G HGFH+H+FGDNT GC SAG H+NP  + HG P DEERHVGDLGNVTA   G  KV+  D V+SL G  SIIGR+LVVHE  DDLGKGG+E SK TGNAGGRLACGV+GI +
Sbjct:    1 MAMKAVCVLKGDSPVQGTINFEQKESNGPVKVWGSITGLTEGLHGFHVHQFGDNTQGCTSAGPHFNPLSRQHGGPKDEERHVGDLGNVTAGKDGVAKVSFEDSVISLSGDHSIIGRTLVVHEKADDLGKGGNEESKKTGNAGGRLACGVIGIAQ 154
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. UniProt/SwissProt
Match: sp|Q8HXQ2|SODC_MACFU (Superoxide dismutase [Cu-Zn] OS=Macaca fuscata fuscata OX=9543 GN=SOD1 PE=2 SV=3)

HSP 1 Score: 195.667 bits (496), Expect = 1.743e-63
Identity = 96/154 (62.34%), Postives = 116/154 (75.32%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            M + AVCVLK ++ + GT+ F Q ++ GPV++   I+GLT G HGFH+H+FGDNT GC SAG H+NP  + HG P DEERHVGDLGNVTA   G  KV+  D V+SL G  SIIGR+LVVHE  DDLGKGG+E SK TGNAGGRLACGV+GI +
Sbjct:    1 MAMKAVCVLKGDSPVQGTINFEQKESNGPVKVWGSITGLTEGLHGFHVHQFGDNTQGCTSAGPHFNPLSRQHGGPKDEERHVGDLGNVTAGKDGVAKVSFEDSVISLSGDHSIIGRTLVVHEKADDLGKGGNEESKKTGNAGGRLACGVIGIAQ 154
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. UniProt/SwissProt
Match: sp|Q8HXQ1|SODC_MACFA (Superoxide dismutase [Cu-Zn] OS=Macaca fascicularis OX=9541 GN=SOD1 PE=2 SV=3)

HSP 1 Score: 195.667 bits (496), Expect = 1.743e-63
Identity = 96/154 (62.34%), Postives = 116/154 (75.32%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            M + AVCVLK ++ + GT+ F Q ++ GPV++   I+GLT G HGFH+H+FGDNT GC SAG H+NP  + HG P DEERHVGDLGNVTA   G  KV+  D V+SL G  SIIGR+LVVHE  DDLGKGG+E SK TGNAGGRLACGV+GI +
Sbjct:    1 MAMKAVCVLKGDSPVQGTINFEQKESNGPVKVWGSITGLTEGLHGFHVHQFGDNTQGCTSAGPHFNPLSRQHGGPKDEERHVGDLGNVTAGKDGVAKVSFEDSVISLSGDHSIIGRTLVVHEKADDLGKGGNEESKKTGNAGGRLACGVIGIAQ 154
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. TrEMBL
Match: A0A0U3DVL0 (Superoxide dismutase [Cu-Zn] OS=Tegillarca granosa OX=220873 PE=2 SV=1)

HSP 1 Score: 217.238 bits (552), Expect = 1.448e-69
Identity = 106/154 (68.83%), Postives = 123/154 (79.87%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            M++ +VCVL+ E  + GTV F Q   G PV++  EISGL PG+HGFHIHEFGDNTNGC SAG HYNPHGK HG P DE RHVGDLGNVTA+A G  K+ + D  +SL GPLSIIGR++VVH + DDLGKGGHE SKTTG+AGGRLACGV+GITK
Sbjct:    1 MSLKSVCVLRGEPGVTGTVNFQQEKNGDPVKVTGEISGLAPGQHGFHIHEFGDNTNGCTSAGPHYNPHGKEHGGPEDENRHVGDLGNVTANADGVAKIEIKDSQLSLTGPLSIIGRTVVVHADVDDLGKGGHEDSKTTGHAGGRLACGVIGITK 154
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. TrEMBL
Match: A0A2D3HL46 (Superoxide dismutase [Cu-Zn] OS=Mytilus coruscus OX=42192 GN=Cu PE=2 SV=1)

HSP 1 Score: 215.312 bits (547), Expect = 9.218e-69
Identity = 102/152 (67.11%), Postives = 121/152 (79.61%), Query Frame = 2 
Query:   29 VHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            + AVCVLK +  + GTV F Q +   PV +  E++GL PG+HGFH+HEFGDNTNGC SAG H+NP GKTHGAP DEERHVGDLGNV+A+A GK  + +TD  +SL GP SIIGR++VVH + DDLGKGGHE SKTTGNAG RLACGV+GITK
Sbjct:    5 IKAVCVLKGDGAVTGTVAFTQQNGDSPVTVTGELTGLAPGEHGFHVHEFGDNTNGCTSAGAHFNPFGKTHGAPADEERHVGDLGNVSANADGKAAINITDAKISLTGPQSIIGRTVVVHADIDDLGKGGHELSKTTGNAGSRLACGVIGITK 156
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. TrEMBL
Match: A0A1Y2GDM2 (Superoxide dismutase [Cu-Zn] OS=Lobosporangium transversale OX=64571 GN=BCR41DRAFT_359694 PE=3 SV=1)

HSP 1 Score: 214.927 bits (546), Expect = 1.186e-68
Identity = 103/155 (66.45%), Postives = 122/155 (78.71%), Query Frame = 2 
Query:   23 MTVHAVCVLK-NENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            MTV AVCV + N+ N+ GT+ F Q +   PV +  E+ GL  GKHGFH+HEFGDNTNGC+SAG H+NPHG+THGAP    RH GDLGNVTADA+GK  + +TD  + L+GP SIIGR++VVHENEDDLG GGHE S TTGNAGGRLACGV+GITK
Sbjct:    1 MTVKAVCVFRANDKNVTGTIHFTQENEAAPVHVQAELGGLPQGKHGFHVHEFGDNTNGCLSAGAHFNPHGQTHGAPDAAVRHAGDLGNVTADANGKATLNITDSQIKLIGPHSIIGRTIVVHENEDDLGLGGHELSATTGNAGGRLACGVIGITK 155
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. TrEMBL
Match: A0A2I7YV68 (Superoxide dismutase [Cu-Zn] OS=Eisenia fetida OX=6396 PE=2 SV=1)

HSP 1 Score: 214.927 bits (546), Expect = 1.323e-68
Identity = 107/154 (69.48%), Postives = 124/154 (80.52%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            M++ AV VL+ +    GTV+F Q +  GPV +  EISGLTPGKHGFH+HEFGDNTNGC SAG H+NP GKTHGAP D+ERHVGDLGNV AD SG  K  +TDK+++L GP SIIGR++VVHE  DDLGKGGHE SKTTGNAGGRLACGV+GI K
Sbjct:    1 MSLVAVSVLRGDGATTGTVRFSQKNPDGPVVVKGEISGLTPGKHGFHVHEFGDNTNGCTSAGAHFNPFGKTHGAPEDQERHVGDLGNVVADESGVAKFEVTDKLLNLTGPNSIIGRTVVVHELVDDLGKGGHEFSKTTGNAGGRLACGVIGICK 154
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. TrEMBL
Match: A0A0M5M0K4 (Superoxide dismutase [Cu-Zn] OS=Eisenia andrei OX=168636 GN=CuZnSOD PE=2 SV=1)

HSP 1 Score: 214.927 bits (546), Expect = 1.323e-68
Identity = 107/154 (69.48%), Postives = 124/154 (80.52%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            M++ AV VL+ +    GTV+F Q +  GPV +  EISGLTPGKHGFH+HEFGDNTNGC SAG H+NP GKTHGAP D+ERHVGDLGNV AD SG  K  +TDK+++L GP SIIGR++VVHE  DDLGKGGHE SKTTGNAGGRLACGV+GI K
Sbjct:    1 MSLVAVSVLRGDGATTGTVRFSQKNPDGPVVVKGEISGLTPGKHGFHVHEFGDNTNGCTSAGAHFNPFGKTHGAPEDQERHVGDLGNVVADESGVAKFEVTDKLLNLTGPNSIIGRTVVVHELVDDLGKGGHEFSKTTGNAGGRLACGVIGICK 154
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Cavefish
Match: sod1 (superoxide dismutase 1 [Source:NCBI gene;Acc:103036754])

HSP 1 Score: 202.601 bits (514), Expect = 2.696e-67
Identity = 102/154 (66.23%), Postives = 118/154 (76.62%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            M   AVCVLK    + GTV F Q D G PV++  EI+GLTPG HGFH+H FGDNTNGCISAG HYNP+ KTHG P DE RHVGDLGNVTA A G  K+ + DK++SL GP SI+GR++V+HE EDDLGKGG E S  TGNAGGRLACGV+GI +
Sbjct:    1 MVHKAVCVLKGTGEVTGTVFFEQGD-GAPVKVSGEITGLTPGLHGFHVHAFGDNTNGCISAGPHYNPYNKTHGGPTDEIRHVGDLGNVTAGADGVAKINIEDKMLSLSGPHSIVGRTMVIHEKEDDLGKGGDEESLKTGNAGGRLACGVIGIAQ 153
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Cavefish
Match: ccs (copper chaperone for superoxide dismutase [Source:ZFIN;Acc:ZDB-GENE-050417-322])

HSP 1 Score: 140.198 bits (352), Expect = 5.046e-42
Identity = 72/146 (49.32%), Postives = 89/146 (60.96%), Query Frame = 2 
Query:   35 AVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVV 472
            AV ++     + G V+F+Q      + ID  I GL PG HG H+HE GD T  C+S G HYNP GK HG P D ERHVGDLGNV A + G+    L D  + +     +IGRSLVV   EDDLG+  H  SK TGN+G RLACG++
Sbjct:   23 AVAMMSGAGRVQGVVRFLQLSENRCL-IDGTIDGLDPGAHGLHVHELGDLTQDCLSCGEHYNPFGKQHGGPADTERHVGDLGNVQAGSDGRATFRLEDSQLKV---WDVIGRSLVVDSGEDDLGRESHPLSKQTGNSGQRLACGII 164
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Cavefish
Match: sod3b (superoxide dismutase 3, extracellular b [Source:ZFIN;Acc:ZDB-GENE-030131-8743])

HSP 1 Score: 115.161 bits (287), Expect = 1.585e-32
Identity = 67/165 (40.61%), Postives = 93/165 (56.36%), Query Frame = 2 
Query:   17 FKMTVHAVCVLKNENNLN-------GTVKFMQSDAGGPVEIDVEISGLT---PGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGIT 481
            F  +++A C ++    L        G V F QS   G + I  ++ GL    P     HIH++GD + GC S GGHYNP G  H        H GD GN T   +GK++ ++ D   +L G LS++GR++V+HE EDDLG+GG   S   GNAGGRLAC V+G++
Sbjct:   19 FSGSLYASCRMRPNTQLTPGSPKVYGQVLFKQSGPEGKLSIRFKLHGLPASDPQPRAIHIHQYGDLSQGCTSTGGHYNPLGYNH------PNHPGDFGNFTPR-NGKIRRSV-DSRATLFGGLSVLGRAVVIHEKEDDLGRGGDAGSLLHGNAGGRLACCVIGLS 175
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Cavefish
Match: sod3a (superoxide dismutase 3, extracellular a [Source:ZFIN;Acc:ZDB-GENE-050309-208])

HSP 1 Score: 101.293 bits (251), Expect = 6.404e-27
Identity = 64/168 (38.10%), Postives = 91/168 (54.17%), Query Frame = 2 
Query:    8 LLLFKMTVHAVCVLKNEN-------NLNGTVKFMQSDAGGPVEIDVEISGLTPG---KHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGIT 481
            L LF   ++  C +  +         L G V F Q    G V++ V + GL      +   HIH++GD + G ++AG HYNP G  H +      H GDLGN    ++G V+  L  +  +L G  SI+GR++V+HE EDDLG G  E SK +GNAG R+A  V+GI+
Sbjct:   31 LELFNRFMYGTCEVNPDPLLPAGLPQLYGQVLFRQFYPSGAVQVIVNLRGLPTNDKQERAIHIHQYGDLSEGFVTAGPHYNPLGVDHPS------HPGDLGNFFP-SNGTVRRRLNVQAATLFGGPSILGRAVVIHEKEDDLGLGSDEESKRSGNAGRRIAGCVIGIS 191
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Sea Lamprey
Match: ccs (copper chaperone for superoxide dismutase [Source:ZFIN;Acc:ZDB-GENE-050417-322])

HSP 1 Score: 127.102 bits (318), Expect = 7.110e-37
Identity = 69/136 (50.74%), Postives = 86/136 (63.24%), Query Frame = 2 
Query:   71 GTVKFMQSDAGGPVEIDVE--ISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVV 472
            G V+F+Q     P+   +E  + GL+PG HG H+HEFGD TNGC S GGH+NPH   HG P D   HVGDLGN+ AD  G+    +    +  VG   IIGRS+VV E  DDLG+G H  SK TGN+G  LACG++
Sbjct:   94 GVVRFVQLS---PLTCAIEGTVDGLSPGPHGLHVHEFGDLTNGCFSCGGHFNPHRSNHGRPDDPNSHVGDLGNIIADEHGRASFRVNSGKIK-VG--DIIGRSVVVDETADDLGRGTHPLSKVTGNSGLGLACGII 223
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Yeast
Match: SOD1 (Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; human ortholog SOD1 implicated in ALS complements a null allele; abundance increases under DNA replication stress and during exposure to boric acid; localization to mitochondrial intermembrane space is modulated by MICOS complex [Source:SGD;Acc:S000003865])

HSP 1 Score: 172.17 bits (435), Expect = 4.324e-56
Identity = 84/152 (55.26%), Postives = 107/152 (70.39%), Query Frame = 2 
Query:   29 VHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTP-GKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGIT 481
            V AV VLK +  ++G VKF Q+    P  +  EI+G +P  + GFHIHEFGD TNGC+SAG H+NP  KTHGAP DE RHVGD+GNV  D +G  K +  D ++ L+GP S++GRS+V+H  +DDLGKG  E S  TGNAG R ACGV+G+T
Sbjct:    2 VQAVAVLKGDAGVSGVVKFEQASESEPTTVSYEIAGNSPNAERGFHIHEFGDATNGCVSAGPHFNPFKKTHGAPTDEVRHVGDMGNVKTDENGVAKGSFKDSLIKLIGPTSVVGRSVVIHAGQDDLGKGDTEESLKTGNAGPRPACGVIGLT 153
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Nematostella
Match: EDO42041 (Superoxide dismutase [Cu-Zn] [Source:UniProtKB/TrEMBL;Acc:A7S2P3])

HSP 1 Score: 197.978 bits (502), Expect = 7.501e-66
Identity = 97/153 (63.40%), Postives = 114/153 (74.51%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGIT 481
            M +  VC L  +N + G + F Q    GP  +   I+GLT GKHGFHIHEFGDNTNGC SAG HYNPHGK HGAP D++RH+GDLGN+ ADA+G   V++TD ++SL G  SIIGRSLVVHE  DDLG GGHE S TTGNAGGR+ACGV+GI 
Sbjct:    1 MVIRGVCCLVGDNEVKGVIHFTQQAPDGPCTLRGRITGLTEGKHGFHIHEFGDNTNGCTSAGAHYNPHGKMHGAPEDKDRHLGDLGNIEADANGIADVSITDCLVSLTGQCSIIGRSLVVHEGMDDLGAGGHELSLTTGNAGGRVACGVIGIA 153
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Nematostella
Match: EDO42040 (Superoxide dismutase [Cu-Zn] [Source:UniProtKB/TrEMBL;Acc:A7S2P2])

HSP 1 Score: 188.348 bits (477), Expect = 5.832e-62
Identity = 91/154 (59.09%), Postives = 113/154 (73.38%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            M + AVC +     + GT+KF+Q   G P +I   I GL  G HGFHIH +GDNTNGC+SAG H+NP  K HG P DE RHVGDLGNV A   GK  + +TD +++LVG  S++GRS+VVH +EDDLG+GGHE SKTTG+AGGRLACGV+GIT+
Sbjct:    1 MPIQAVCCMSGTEGVKGTIKFVQEAEGKPCKITGTIEGLKAGNHGFHIHVYGDNTNGCVSAGPHFNPFKKEHGGPSDENRHVGDLGNVVAGDDGKACIDMTDALVTLVGEHSVVGRSVVVHADEDDLGRGGHEDSKTTGHAGGRLACGVIGITQ 154
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Nematostella
Match: EDO43919 (Superoxide dismutase [Cu-Zn] [Source:UniProtKB/TrEMBL;Acc:A7RX84])

HSP 1 Score: 123.635 bits (309), Expect = 5.834e-37
Identity = 67/124 (54.03%), Postives = 84/124 (67.74%), Query Frame = 2 
Query:  116 IDVEISGLTP-GKHGFHIHEFGDN-TNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHET---SKTTGNAGGRLACGVV 472
            I+V + G+ P   HGFHIH+ GD  T GC SA GH+NP+GKTH  P   +RHVGDLGNV +D  G V+ +  D ++SL GP S+IGRS+V+H   DDLG+G  E    S  TGNAG RLAC V+
Sbjct:    1 INVRLRGVPPLTVHGFHIHKSGDIITKGCQSAKGHFNPYGKTHAGPRKRDRHVGDLGNVWSDYHGNVRTSFFDHMVSLYGPDSVIGRSIVLHAERDDLGRGIGEYRTGSLATGNAGARLACCVI 124
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Medaka
Match: sod1 (superoxide dismutase 1 [Source:NCBI gene;Acc:101170534])

HSP 1 Score: 191.43 bits (485), Expect = 7.271e-63
Identity = 94/154 (61.04%), Postives = 113/154 (73.38%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            M + AVCVLK     NG V F Q     PV++  EI GLTPGKHGFHIH +GDNTNGC+SAG H+NP+ K HG P D ERHVGDLGNVTA  +   K+ +TDK++ L GP SI+GR++VVHE  DDLGKGG++ S  TGNAG RLACGV+GI +
Sbjct:    1 MVLKAVCVLKGTGETNGVVNFEQESDSAPVKVTGEIKGLTPGKHGFHIHVYGDNTNGCVSAGPHFNPYNKNHGGPEDAERHVGDLGNVTAGDNNVAKIDITDKLIRLSGPDSIVGRTVVVHEKVDDLGKGGNDESLKTGNAGARLACGVIGIAQ 154
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Medaka
Match: ccs (copper chaperone for superoxide dismutase [Source:NCBI gene;Acc:101157814])

HSP 1 Score: 131.339 bits (329), Expect = 7.869e-38
Identity = 71/146 (48.63%), Postives = 87/146 (59.59%), Query Frame = 2 
Query:   35 AVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVV 472
            AV +L    ++ G V+F+Q      + ID  I GL PG HG H+H  GD T  C S G HYNP GK HG P D ERHVGDLGN+ A   G+    L D  + +     +IGRSLVV   EDDLG+G H  SK TGN+G RLA G++
Sbjct:   84 AVAMLSGAGSIQGVVRFLQLSEKHCL-IDGTIDGLEPGCHGLHVHTLGDLTQDCKSCGEHYNPFGKQHGGPGDSERHVGDLGNIVAGPDGRASFRLEDDQLKV---WDVIGRSLVVDGGEDDLGRGTHPLSKQTGNSGERLAFGII 225
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Medaka
Match: ccs (copper chaperone for superoxide dismutase [Source:NCBI gene;Acc:101157814])

HSP 1 Score: 125.176 bits (313), Expect = 2.212e-35
Identity = 68/140 (48.57%), Postives = 82/140 (58.57%), Query Frame = 2 
Query:   35 AVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGR 454
            AV +L    ++ G V+F+Q      + ID  I GL PG HG H+H  GD T  C S G HYNP GK HG P D ERHVGDLGN+ A   G+    L D  + +     +IGRSLVV   EDDLG+G H  SK TGN+G R
Sbjct:   84 AVAMLSGAGSIQGVVRFLQLSEKHCL-IDGTIDGLEPGCHGLHVHTLGDLTQDCKSCGEHYNPFGKQHGGPGDSERHVGDLGNIVAGPDGRASFRLEDDQLKV---WDVIGRSLVVDGGEDDLGRGTHPLSKQTGNSGER 219
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Medaka
Match: sod3b (superoxide dismutase 3 [Source:NCBI gene;Acc:101169658])

HSP 1 Score: 103.99 bits (258), Expect = 6.932e-28
Identity = 61/164 (37.20%), Postives = 90/164 (54.88%), Query Frame = 2 
Query:   26 TVHAVCVLKNENNL-------NGTVKFMQSDAGGPVEIDVEISGL----TPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            T++A C +    +L        G   F Q    G +++ ++++G     +P     HIH++GD + GCIS GGHYNP+G       D   H GD GN  A   G++   +  +  +L G LS++GR++VVHE  DDLG+GG   S   GNAG RLAC V+G++ 
Sbjct:   43 TLYAACKVSPSTSLPDDLPKVYGQALFKQDHGQGKLQVLLQLAGFPEDESPQSRAIHIHQYGDLSQGCISTGGHYNPYG------VDHPNHPGDFGNFVAH-EGRISEQIESEA-TLFGGLSVLGRAVVVHETIDDLGQGGDVGSLLHGNAGRRLACCVIGMSS 198
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Planmine SMEST
Match: SMESG000020880.1 (SMESG000020880.1)

HSP 1 Score: 308.531 bits (789), Expect = 2.989e-109
Identity = 154/154 (100.00%), Postives = 154/154 (100.00%), Query Frame = 2 
Query:   23 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 484
            MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK
Sbjct:    1 MTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGKHGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGITK 154
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Planmine SMEST
Match: SMESG000051067.1 (SMESG000051067.1)

HSP 1 Score: 121.709 bits (304), Expect = 4.252e-35
Identity = 66/158 (41.77%), Postives = 92/158 (58.23%), Query Frame = 2 
Query:   35 AVCVLKNENNLNGTVKFMQSDAGGPVEIDVEIS---------GLTPGK-HGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGI 478
            A+C++   +NL+  +        G +E++ +           GL P   HG HIHEFGD    C  AG HYNP  K HGAP  ++RH+GDLGNV +D  GKV +T  D V+ L G  S+IGRS+++H++ED          + +GNAGGRLAC V+G+
Sbjct:   41 AICLMNQNSNLHLKI-------SGQIELEQQNKIISIKINIYGLHPNSIHGLHIHEFGDLRESCNKAGAHYNPFQKRHGAPTSQDRHIGDLGNVVSDLHGKVTITKLDTVIKLTGINSVIGRSVILHKHEDKY------PFQPSGNAGGRLACCVIGL 185
[Close]
BLAST of Superoxide dismutase [Cu-Zn] vs. Planmine SMEST
Match: SMESG000005021.1 (SMESG000005021.1)

HSP 1 Score: 115.546 bits (288), Expect = 7.108e-33
Identity = 60/141 (42.55%), Postives = 82/141 (58.16%), Query Frame = 2 
Query:   62 NLNGTVKFMQSDAGGPVEIDVEISGLTPGK-HGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGIT 481
            N+ G V   +      V I   I GL P   HGFHIH+FGD  N C++ G HYNP+ K HG P D  RH GD GN+ A+  G++ +  +D +  L G  S IGR+ V+HE  D+       +++  G+AGGR+ACGV+GI 
Sbjct:   42 NIYGVVNLTEMKKS--VIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNIARLTGKYSAIGRAFVLHERRDNY------SAQPVGDAGGRVACGVIGIA 174
The following BLAST results are available for this feature:
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SOD11.783e-6060.39superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGN... [more]
SOD14.157e-5362.88superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGN... [more]
CCS3.233e-4147.97copper chaperone for superoxide dismutase [Source:... [more]
CCS3.920e-4147.97copper chaperone for superoxide dismutase [Source:... [more]
SOD32.776e-2437.04superoxide dismutase 3 [Source:HGNC Symbol;Acc:HGN... [more]
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BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sod-18.821e-5455.13Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Sw... [more]
sod-16.953e-5354.84Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Sw... [more]
sod-16.953e-5354.84Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Sw... [more]
sod-43.048e-5256.55Extracellular superoxide dismutase [Cu-Zn] [Sourc... [more]
sod-41.079e-5157.04Extracellular superoxide dismutase [Cu-Zn] [Sourc... [more]
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BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Sod13.927e-5957.79gene:FBgn0003462 transcript:FBtr0076229[more]
Sod33.669e-5355.41gene:FBgn0033631 transcript:FBtr0089938[more]
Sod33.669e-5355.41gene:FBgn0033631 transcript:FBtr0433531[more]
Sod33.669e-5355.41gene:FBgn0033631 transcript:FBtr0089939[more]
Sod36.861e-5355.41gene:FBgn0033631 transcript:FBtr0110897[more]
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BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sod11.268e-6765.58superoxide dismutase 1, soluble [Source:NCBI gene;... [more]
ccs3.049e-4149.66copper chaperone for superoxide dismutase [Source:... [more]
ccs7.534e-4149.66copper chaperone for superoxide dismutase [Source:... [more]
sod3a1.731e-2737.95superoxide dismutase 3, extracellular a [Source:ZF... [more]
sod3b3.393e-2738.51superoxide dismutase 3, extracellular b [Source:ZF... [more]
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BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sod12.721e-5964.47superoxide dismutase 1 [Source:NCBI gene;Acc:54900... [more]
ccs9.261e-4148.30copper chaperone for superoxide dismutase [Source:... [more]
ccs3.382e-2840.82copper chaperone for superoxide dismutase [Source:... [more]
sh3rf23.824e-2839.38SH3 domain containing ring finger 2 [Source:Xenbas... [more]
ccs2.528e-2352.17copper chaperone for superoxide dismutase [Source:... [more]
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BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Sod14.078e-6460.39superoxide dismutase 1, soluble [Source:MGI Symbol... [more]
Ccs5.255e-4147.95copper chaperone for superoxide dismutase [Source:... [more]
Ccs5.841e-4147.95copper chaperone for superoxide dismutase [Source:... [more]
Ccs6.485e-4147.95copper chaperone for superoxide dismutase [Source:... [more]
Ccs2.333e-3852.94copper chaperone for superoxide dismutase [Source:... [more]
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BLAST of Superoxide dismutase [Cu-Zn] vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O73872|SODC_DANRE9.573e-6765.58Superoxide dismutase [Cu-Zn] OS=Danio rerio OX=795... [more]
sp|P10792|SODCP_PETHY1.261e-6362.03Superoxide dismutase [Cu-Zn], chloroplastic OS=Pet... [more]
sp|Q8HXQ0|SODC_MACMU1.743e-6362.34Superoxide dismutase [Cu-Zn] OS=Macaca mulatta OX=... [more]
sp|Q8HXQ2|SODC_MACFU1.743e-6362.34Superoxide dismutase [Cu-Zn] OS=Macaca fuscata fus... [more]
sp|Q8HXQ1|SODC_MACFA1.743e-6362.34Superoxide dismutase [Cu-Zn] OS=Macaca fasciculari... [more]
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BLAST of Superoxide dismutase [Cu-Zn] vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0U3DVL01.448e-6968.83Superoxide dismutase [Cu-Zn] OS=Tegillarca granosa... [more]
A0A2D3HL469.218e-6967.11Superoxide dismutase [Cu-Zn] OS=Mytilus coruscus O... [more]
A0A1Y2GDM21.186e-6866.45Superoxide dismutase [Cu-Zn] OS=Lobosporangium tra... [more]
A0A2I7YV681.323e-6869.48Superoxide dismutase [Cu-Zn] OS=Eisenia fetida OX=... [more]
A0A0M5M0K41.323e-6869.48Superoxide dismutase [Cu-Zn] OS=Eisenia andrei OX=... [more]
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BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
sod12.696e-6766.23superoxide dismutase 1 [Source:NCBI gene;Acc:10303... [more]
ccs5.046e-4249.32copper chaperone for superoxide dismutase [Source:... [more]
sod3b1.585e-3240.61superoxide dismutase 3, extracellular b [Source:ZF... [more]
sod3a6.404e-2738.10superoxide dismutase 3, extracellular a [Source:ZF... [more]
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BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ccs7.110e-3750.74copper chaperone for superoxide dismutase [Source:... [more]
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BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
SOD14.324e-5655.26Cytosolic copper-zinc superoxide dismutase; detoxi... [more]
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BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO420417.501e-6663.40Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Tr... [more]
EDO420405.832e-6259.09Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Tr... [more]
EDO439195.834e-3754.03Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Tr... [more]
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BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
sod17.271e-6361.04superoxide dismutase 1 [Source:NCBI gene;Acc:10117... [more]
ccs7.869e-3848.63copper chaperone for superoxide dismutase [Source:... [more]
ccs2.212e-3548.57copper chaperone for superoxide dismutase [Source:... [more]
sod3b6.932e-2837.20superoxide dismutase 3 [Source:NCBI gene;Acc:10116... [more]
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BLAST of Superoxide dismutase [Cu-Zn] vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000020880.12.989e-109100.00SMESG000020880.1[more]
SMESG000051067.14.252e-3541.77SMESG000051067.1[more]
SMESG000005021.17.108e-3342.55SMESG000005021.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30024804 ID=SMED30024804|Name=Superoxide dismutase [Cu-Zn]|organism=Schmidtea mediterranea sexual|type=transcript|length=522bp
TAATTTTTTGTTATTATTTAAAATGACAGTTCATGCTGTATGCGTTTTGA
AGAATGAAAACAATTTAAACGGAACGGTTAAATTTATGCAAAGCGATGCT
GGAGGTCCTGTAGAGATTGACGTAGAAATAAGTGGTCTAACTCCTGGTAA
ACACGGTTTCCATATACACGAATTTGGCGACAATACAAATGGATGTATTT
CAGCTGGTGGACATTACAATCCACACGGTAAAACTCACGGAGCTCCTTGC
GACGAAGAACGTCACGTAGGAGATCTTGGAAACGTAACGGCTGATGCTAG
TGGAAAAGTTAAAGTTACGCTCACGGATAAAGTTATGTCACTAGTTGGTC
CTTTATCCATTATTGGCCGTTCATTGGTTGTTCATGAAAATGAAGACGAT
TTAGGAAAAGGAGGCCACGAAACTAGCAAAACTACAGGTAATGCTGGTGG
TCGATTAGCGTGTGGAGTAGTTGGAATTACAAAATAATTTTGTTAACACG
TTTATAATAAATGTTGTGATTA
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protein sequence of SMED30024804-orf-1

>SMED30024804-orf-1 ID=SMED30024804-orf-1|Name=SMED30024804-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=162bp
NFLLLFKMTVHAVCVLKNENNLNGTVKFMQSDAGGPVEIDVEISGLTPGK
HGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADAS
GKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGG
RLACGVVGITK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR036423SOD-like_Cu/Zn_dom_sf
IPR024134SOD_Cu/Zn_/chaperone
IPR001424SOD_Cu_Zn_dom
IPR018152SOD_Cu/Zn_BS
Vocabulary: molecular function
TermDefinition
GO:0046872metal ion binding
GO:0004784superoxide dismutase activity
GO:0016491oxidoreductase activity
Vocabulary: biological process
TermDefinition
GO:0006801superoxide metabolic process
GO:0055114oxidation-reduction process
GO:0019430removal of superoxide radicals
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001424Superoxide dismutase, copper/zinc binding domainPRINTSPR00068CUZNDISMTASEcoord: 52..74
score: 72.12
coord: 88..97
score: 76.6
coord: 107..129
score: 53.16
coord: 132..158
score: 74.84
IPR001424Superoxide dismutase, copper/zinc binding domainPFAMPF00080Sod_Cucoord: 19..157
e-value: 1.6E-50
score: 171.0
IPR001424Superoxide dismutase, copper/zinc binding domainCDDcd00305Cu-Zn_Superoxide_Dismutasecoord: 12..154
e-value: 2.7674E-64
score: 191.705
IPR036423Superoxide dismutase-like, copper/zinc binding domain superfamilyGENE3DG3DSA:2.60.40.200coord: 7..161
e-value: 8.2E-65
score: 219.7
IPR036423Superoxide dismutase-like, copper/zinc binding domain superfamilySUPERFAMILYSSF49329Cu,Zn superoxide dismutase-likecoord: 9..159
IPR024134Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperonePANTHERPTHR10003SUPEROXIDE DISMUTASE CU-ZN -RELATEDcoord: 7..160
NoneNo IPR availablePANTHERPTHR10003:SF71SUPEROXIDE DISMUTASE [CU-ZN]coord: 7..160
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..12
score: 0.456
IPR018152Superoxide dismutase, copper/zinc, binding sitePROSITEPS00087SOD_CU_ZN_1coord: 52..62
IPR018152Superoxide dismutase, copper/zinc, binding sitePROSITEPS00332SOD_CU_ZN_2coord: 146..157