Cystatin

Overview
NameCystatin
Smed IDSMED30024754
Length (bp)693
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Cystatin (SMED30024754) t-SNE clustered cells

Violin plots show distribution of expression levels for Cystatin (SMED30024754) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cystatin (SMED30024754) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Cystatin (SMED30024754) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Homology
[Close]
BLAST of Cystatin vs. Ensembl Human
Match: CSTA (cystatin A [Source:HGNC Symbol;Acc:HGNC:2481])

HSP 1 Score: 72.0182 bits (175), Expect = 7.409e-16
Identity = 37/98 (37.76%), Postives = 61/98 (62.24%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQG-DLALHGLR-EKSEGDSLEYF 409
            M+ GG + A+  T E  +I+  +KP++EE+        + +  K+Q+VAG NY+ K+  G+ K++H++VFK LPGQ  DL L G + +K++ D L  F
Sbjct:    1 MIPGGLSEAKPATPEIQEIVDKVKPQLEEKTNETYGKLEAVQYKTQVVAGTNYYIKVRAGDNKYMHLKVFKSLPGQNEDLVLTGYQVDKNKDDELTGF 98
[Close]
BLAST of Cystatin vs. Ensembl Human
Match: CSTB (cystatin B [Source:HGNC Symbol;Acc:HGNC:2482])

HSP 1 Score: 71.633 bits (174), Expect = 1.070e-15
Identity = 37/98 (37.76%), Postives = 56/98 (57.14%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGD-LALHGLR-EKSEGDSLEYF 409
            M+CG  +  +  T E   I   ++ ++EE+   K   F  +S KSQ+VAG NYF K+H+G+   VH+RVF+ LP +   L L   +  K++ D L YF
Sbjct:    1 MMCGAPSATQPATAETQHIADQVRSQLEEKENKKFPVFKAVSFKSQVVAGTNYFIKVHVGDEDFVHLRVFQSLPHENKPLTLSNYQTNKAKHDELTYF 98
[Close]
BLAST of Cystatin vs. Ensembl Human
Match: CSTB (cystatin B [Source:HGNC Symbol;Acc:HGNC:2482])

HSP 1 Score: 48.521 bits (114), Expect = 2.572e-7
Identity = 22/60 (36.67%), Postives = 33/60 (55.00%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLG 301
            M+CG  +  +  T E   I   ++ ++EE+   K   F  +S KSQ+VAG NYF K+  G
Sbjct:    1 MMCGAPSATQPATAETQHIADQVRSQLEEKENKKFPVFKAVSFKSQVVAGTNYFIKVECG 60
[Close]
BLAST of Cystatin vs. Ensembl Zebrafish
Match: cst14a.2 (cystatin 14a, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-040426-1065])

HSP 1 Score: 85.8853 bits (211), Expect = 2.193e-21
Identity = 42/98 (42.86%), Postives = 64/98 (65.31%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGD-LALHGLR-EKSEGDSLEYF 409
            ++CGGT+ A++  EE  KI   +K   EE+ G K + F   S K+Q+VAG NYF K+H+G+  +VH+RV+K LP  G+ L L  ++  K+  D++EYF
Sbjct:    3 LVCGGTSEAKDANEEVQKICDQMKADAEEKAGRKFDVFTAKSFKTQLVAGTNYFVKVHVGDEDYVHLRVYKTLPHAGETLQLTSIQTAKAHHDAIEYF 100
[Close]
BLAST of Cystatin vs. Ensembl Zebrafish
Match: cst14a.1 (cystatin 14a, tandem duplicate 1 [Source:ZFIN;Acc:ZDB-GENE-141031-1])

HSP 1 Score: 81.2629 bits (199), Expect = 1.203e-19
Identity = 41/98 (41.84%), Postives = 63/98 (64.29%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGD-LALHGLR-EKSEGDSLEYF 409
            ++ GGT+ A++  EE  KI   +K   EE+ G K + F   S K+Q+VAG NYF K+H+G+  +VH+RV+K LP  G+ L L  ++  K+  D++EYF
Sbjct:    3 LVRGGTSEAKDANEEVQKICDKMKADAEEKAGRKFDVFTAKSFKTQVVAGTNYFVKVHVGDEDYVHLRVYKTLPHAGETLQLTSIQTAKAHHDAIEYF 100
[Close]
BLAST of Cystatin vs. Ensembl Zebrafish
Match: cst14a.1 (cystatin 14a, tandem duplicate 1 [Source:ZFIN;Acc:ZDB-GENE-141031-1])

HSP 1 Score: 81.2629 bits (199), Expect = 1.203e-19
Identity = 41/98 (41.84%), Postives = 63/98 (64.29%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGD-LALHGLR-EKSEGDSLEYF 409
            ++ GGT+ A++  EE  KI   +K   EE+ G K + F   S K+Q+VAG NYF K+H+G+  +VH+RV+K LP  G+ L L  ++  K+  D++EYF
Sbjct:    3 LVRGGTSEAKDANEEVQKICDKMKADAEEKAGRKFDVFTAKSFKTQVVAGTNYFVKVHVGDEDYVHLRVYKTLPHAGETLQLTSIQTAKAHHDAIEYF 100
[Close]
BLAST of Cystatin vs. Ensembl Zebrafish
Match: cst14b.1 (cystatin 14b, tandem duplicate 1 [Source:NCBI gene;Acc:768128])

HSP 1 Score: 70.0922 bits (170), Expect = 2.962e-15
Identity = 37/95 (38.95%), Postives = 56/95 (58.95%), Query Frame = 2 
Query:  131 GGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGD-LALHGLR-EKSEGDSLEYF 409
            GG +  +  T E  KI  ++K + EE+ G K   F  +   +Q+VAG NYF K+++G  + +H+RV KPLP  GD + L G++  KS  D + YF
Sbjct:    7 GGQSEEKQATPEVQKICDEVKHQAEEKAGKKFTAFTAILFTTQVVAGTNYFIKVNVGGDQFIHLRVHKPLPHAGDKVQLQGIQVSKSCQDPIHYF 101
[Close]
BLAST of Cystatin vs. Ensembl Zebrafish
Match: cst14b.2 (cystatin 14b, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-140912-1])

HSP 1 Score: 51.2174 bits (121), Expect = 3.091e-8
Identity = 24/79 (30.38%), Postives = 41/79 (51.90%), Query Frame = 2 
Query:  116 SNMLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQG 352
            S    G  +N    T E +KI L +K  ++ ++   C+ F   + +SQ+VAG NY  K+ +   +  H+ +F+ LP  G
Sbjct:    2 SEAKAGAWSNEAPVTLEVLKICLQVKETIQAKIPVNCDDFIPHTFRSQLVAGTNYLVKVFIAGDECAHVWIFQDLPCNG 80
[Close]
BLAST of Cystatin vs. Ensembl Xenopus
Match: ercc6l2 (excision repair cross-complementation group 6 like 2 [Source:Xenbase;Acc:XB-GENE-952480])

HSP 1 Score: 73.1738 bits (178), Expect = 2.159e-16
Identity = 36/99 (36.36%), Postives = 61/99 (61.62%), Query Frame = 2 
Query:  116 SNMLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGDLALHGLREKSEGDS-LEYF 409
            S  L GG +  R PT ++ KI   ++ +V+ +   K ETF+++ + +QIVAG NYF K+ +G+  ++HIRV++ L   G ++L  +++    DS L YF
Sbjct:    2 SRPLAGGMSAPREPTPDDQKIADQVQAEVKAKTNQKIETFEVVEVATQIVAGTNYFMKVKVGSTDYIHIRVYQDL--SGTVSLSDVKDCQTKDSPLVYF 98
[Close]
BLAST of Cystatin vs. Ensembl Xenopus
Match: ercc6l2 (excision repair cross-complementation group 6 like 2 [Source:Xenbase;Acc:XB-GENE-952480])

HSP 1 Score: 72.4034 bits (176), Expect = 4.276e-16
Identity = 38/99 (38.38%), Postives = 61/99 (61.62%), Query Frame = 2 
Query:  116 SNMLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGDLALHGLREKSEGDS-LEYF 409
            S  L GG +  R PT ++ KI   ++ +V+ +   K ETF+++ + +QIVAG NYF KI +G  +++HIRV + L   G+++L  ++E    DS L YF
Sbjct:    2 SRPLAGGMSAPREPTPDDQKIADQVQAEVKAKTNQKIETFEVVEVATQIVAGTNYFMKIKVGPNEYIHIRVNQDL--SGNVSLSDVKECETKDSPLVYF 98
[Close]
BLAST of Cystatin vs. Ensembl Xenopus
Match: ercc6l2 (excision repair cross-complementation group 6 like 2 [Source:Xenbase;Acc:XB-GENE-952480])

HSP 1 Score: 67.3958 bits (163), Expect = 3.978e-14
Identity = 32/94 (34.04%), Postives = 58/94 (61.70%), Query Frame = 2 
Query:  131 GGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGDLALHGLREKSEGDS-LEYF 409
            GG +  R  T ++ KI   ++ +V+ +   K ETF+++ + +Q+VAG NYF K+ +G+  ++HIRV++ L   G ++L  +++    DS L YF
Sbjct:    7 GGISTPRKATPDDQKIAEQVQAEVKAKTNQKIETFEVVEVATQVVAGTNYFMKVKVGSTDYIHIRVYQDL--SGTVSLSDVKDCQTKDSPLVYF 98
[Close]
BLAST of Cystatin vs. Ensembl Xenopus
Match: ENSXETT00000037497.1 (cystatin-A5-like [Source:NCBI gene;Acc:105946733])

HSP 1 Score: 50.0618 bits (118), Expect = 5.575e-8
Identity = 23/71 (32.39%), Postives = 48/71 (67.61%), Query Frame = 2 
Query:  185 DIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGDLALHGLREKSEGDS 397
            D+K K+E+ +    +TF+ + + +Q+V+G NYF KI++G+  ++HIRV++    +G+++L  +++    DS
Sbjct:   12 DVKAKIEQNI----DTFEAVLVATQLVSGTNYFMKINVGSPDYIHIRVYQ--DPKGNVSLSYVKQCETKDS 76
[Close]
BLAST of Cystatin vs. Ensembl Mouse
Match: Csta1 (cystatin A1 [Source:MGI Symbol;Acc:MGI:3524930])

HSP 1 Score: 79.337 bits (194), Expect = 7.408e-19
Identity = 43/97 (44.33%), Postives = 58/97 (59.79%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGDLALHGLR-EKSEGDSLEYF 409
            M+ GG T AR  T E  +I   +K ++EE    K E F  +  K+Q+VAGVNYF K+ +G G   HI+VFK L G+ +L L G +  K+E D L YF
Sbjct:    1 MIPGGLTEARPATAEVQEIADRVKAQLEEETNEKYEIFKAVEYKTQVVAGVNYFIKMDVGGGCFTHIKVFKDLSGKNNLELTGYQTNKTEDDELTYF 97
[Close]
BLAST of Cystatin vs. Ensembl Mouse
Match: Cstdc4 (cystatin domain containing 4 [Source:MGI Symbol;Acc:MGI:3645124])

HSP 1 Score: 75.485 bits (184), Expect = 2.001e-17
Identity = 41/97 (42.27%), Postives = 58/97 (59.79%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGDLALHGLR-EKSEGDSLEYF 409
            M+ GG + AR+ T E  +I   +K  +EE+   K E F  +  KSQ+VAG NYF K+ +G G  +HI+VFK + G+  L LHG +  K+  D L YF
Sbjct:    1 MMPGGLSRARSATPEIQEIADKVKSLLEEKTNEKYEVFKAVEYKSQVVAGQNYFIKMDVGGGCFLHIKVFKGISGENVLELHGYQTNKTRKDELSYF 97
[Close]
BLAST of Cystatin vs. Ensembl Mouse
Match: Csta3 (cystatin A family member 3 [Source:MGI Symbol;Acc:MGI:3644688])

HSP 1 Score: 74.3294 bits (181), Expect = 6.939e-17
Identity = 38/97 (39.18%), Postives = 58/97 (59.79%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGDLALHGLR-EKSEGDSLEYF 409
            M+ GG + AR  T E  +I   ++P++E R   K E F+ +  KSQ VAG NYF K+ +G G  +HI+V++   G+ +  LHG +  K++ D L YF
Sbjct:    1 MILGGVSEARPATPEIQEIANKVRPQLEARTSEKYEKFEAVEYKSQFVAGRNYFIKMDVGCGCFLHIKVYRAHSGKDNFELHGYQTNKTKTDELTYF 97
[Close]
BLAST of Cystatin vs. Ensembl Mouse
Match: Csta2 (cystatin A family member 2 [Source:MGI Symbol;Acc:MGI:1924020])

HSP 1 Score: 70.8626 bits (172), Expect = 1.301e-15
Identity = 39/97 (40.21%), Postives = 56/97 (57.73%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGDLALHGLR-EKSEGDSLEYF 409
            M+ GG + AR+ T E  +I   +K  +EE+   K E F  +  KSQ+VAG NYF K+ +G G  +HI+VF  + G+  L L G +  K+  D L YF
Sbjct:    1 MMPGGLSRARSATPEIQEIANKVKSLLEEKTNEKYEVFKAVEYKSQVVAGQNYFIKMDVGGGCFLHIKVFTGISGENVLELSGYQTNKTRKDELSYF 97
[Close]
BLAST of Cystatin vs. Ensembl Mouse
Match: Csta2 (cystatin A family member 2 [Source:MGI Symbol;Acc:MGI:1924020])

HSP 1 Score: 70.8626 bits (172), Expect = 1.301e-15
Identity = 39/97 (40.21%), Postives = 56/97 (57.73%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGDLALHGLR-EKSEGDSLEYF 409
            M+ GG + AR+ T E  +I   +K  +EE+   K E F  +  KSQ+VAG NYF K+ +G G  +HI+VF  + G+  L L G +  K+  D L YF
Sbjct:    1 MMPGGLSRARSATPEIQEIANKVKSLLEEKTNEKYEVFKAVEYKSQVVAGQNYFIKMDVGGGCFLHIKVFTGISGENVLELSGYQTNKTRKDELSYF 97
[Close]
BLAST of Cystatin vs. UniProt/SwissProt
Match: sp|P56567|CYTA_MOUSE (Cystatin-A OS=Mus musculus OX=10090 GN=Csta PE=3 SV=1)

HSP 1 Score: 79.337 bits (194), Expect = 5.182e-18
Identity = 43/97 (44.33%), Postives = 58/97 (59.79%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGDLALHGLR-EKSEGDSLEYF 409
            M+ GG T AR  T E  +I   +K ++EE    K E F  +  K+Q+VAGVNYF K+ +G G   HI+VFK L G+ +L L G +  K+E D L YF
Sbjct:    1 MIPGGLTEARPATAEVQEIADRVKAQLEEETNEKYEIFKAVEYKTQVVAGVNYFIKMDVGGGCFTHIKVFKDLSGKNNLELTGYQTNKTEDDELTYF 97
[Close]
BLAST of Cystatin vs. UniProt/SwissProt
Match: sp|J7FQE8|CYTB_OPLFA (Cystatin-B OS=Oplegnathus fasciatus OX=163134 PE=2 SV=1)

HSP 1 Score: 78.9518 bits (193), Expect = 8.849e-18
Identity = 41/99 (41.41%), Postives = 60/99 (60.61%), Query Frame = 2 
Query:  119 NMLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQ-GDLALHGLR-EKSEGDSLEYF 409
            +M+CGG +   +  E+  K+  ++KP  EE+ G K + F   +  +QIV+G NYF KIH+G   HVH+RV+K LP   G L L G++  KS  D + YF
Sbjct:    2 SMMCGGISAPLDADEDIQKMCDNVKPHAEEKAGKKYDVFTAKTYTTQIVSGTNYFIKIHVGGDDHVHLRVYKKLPCHGGGLELSGMQHSKSLQDPIAYF 100
[Close]
BLAST of Cystatin vs. UniProt/SwissProt
Match: sp|P35479|CPI1_PIG (Leukocyte cysteine proteinase inhibitor 1 OS=Sus scrofa OX=9823 PE=1 SV=1)

HSP 1 Score: 77.0258 bits (188), Expect = 5.361e-17
Identity = 42/98 (42.86%), Postives = 60/98 (61.22%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGD-LALHGLR-EKSEGDSLEYF 409
            ML GG T  R  T E  +I   +KP++EE+     E F+ +  +SQ+VAG NY+ K+H+G   +VHIRVF+ LP Q D L L G + +K++ D L  F
Sbjct:    6 MLAGGLTEPRPATPEIQEIANKVKPQLEEKTNKTYEKFEAIIYRSQVVAGTNYYIKVHVGGNNYVHIRVFQSLPHQEDPLKLIGYQVDKTKDDELTGF 103
[Close]
BLAST of Cystatin vs. UniProt/SwissProt
Match: sp|Q28988|CYTA1_PIG (Cystatin-A1 OS=Sus scrofa OX=9823 PE=1 SV=1)

HSP 1 Score: 76.6406 bits (187), Expect = 7.203e-17
Identity = 41/98 (41.84%), Postives = 60/98 (61.22%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGD-LALHGLR-EKSEGDSLEYF 409
            M+ GG T AR  T E  +I   +K ++EE+     E F+ +  KSQ+VAG+NY+ K+H+G   +VHI+VFK LP Q   L L G + +K++ D L  F
Sbjct:    6 MMPGGLTEARPATPEIQEIATTVKSQLEEKTNKTYEKFEAVEYKSQVVAGINYYIKVHVGGNSYVHIKVFKSLPYQNKPLELSGYQVDKTKDDELTGF 103
[Close]
BLAST of Cystatin vs. UniProt/SwissProt
Match: sp|B2Z449|CYTB_PAROL (Cystatin-B OS=Paralichthys olivaceus OX=8255 PE=1 SV=1)

HSP 1 Score: 75.0998 bits (183), Expect = 1.993e-16
Identity = 44/101 (43.56%), Postives = 60/101 (59.41%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKS---QIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGD-LALHG-LREKSEGDSLEYF 409
            MLCGGT+   +  E+  KI   +KP  E + G   +TFD+   K+   Q V G NYF K+H+G  +HVH+RV+K LP  G+ L L   L++K   D LEYF
Sbjct:    1 MLCGGTSQPVDADEQIQKICDSMKPHAEAQAG---KTFDVFVAKTYTTQCVPGTNYFIKVHVGGDEHVHLRVYKKLPCNGETLELSKMLQDKRHHDPLEYF 98
[Close]
BLAST of Cystatin vs. TrEMBL
Match: A0A267E0R7 (Cystatin domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig014280g2 PE=4 SV=1)

HSP 1 Score: 106.686 bits (265), Expect = 6.716e-26
Identity = 52/105 (49.52%), Postives = 72/105 (68.57%), Query Frame = 2 
Query:  113 KSNM-LCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGD-LALHGLR-EKSEGDSLEYFDKD 418
            + NM LCGGT  AR P+ EE+++L+ ++P VE RLG   E F+   + +Q+VAG NYFAK+H+G+   VHIRVFKPLP   +  ALHG++ EKS  D L +F  +
Sbjct:    4 QPNMPLCGGTGEARQPSPEEVELLVAMRPHVESRLGRSVEQFEPRLVATQVVAGTNYFAKVHIGSDSFVHIRVFKPLPHTNEPPALHGIQAEKSASDELAFFSSE 108
[Close]
BLAST of Cystatin vs. TrEMBL
Match: A0A267DNU0 (Cystatin domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig030572g3 PE=4 SV=1)

HSP 1 Score: 105.531 bits (262), Expect = 1.473e-25
Identity = 50/100 (50.00%), Postives = 69/100 (69.00%), Query Frame = 2 
Query:  125 LCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGD-LALHGLR-EKSEGDSLEYFDKD 418
            LCGGT  AR P+ EE+++L+ ++P VE RLG   E F+   + +Q+VAG NYFAK+H+G+   VHIRVFKPLP   +  ALHG++ EKS  D L +F  +
Sbjct:    9 LCGGTGEARQPSPEEVELLVAMRPHVESRLGRSVEQFEPRLVATQVVAGTNYFAKVHIGSDSFVHIRVFKPLPHTNEPPALHGIQAEKSASDELAFFSSE 108
[Close]
BLAST of Cystatin vs. TrEMBL
Match: A0A5N5KS33 (Uncharacterized protein OS=Pangasianodon hypophthalmus OX=310915 GN=PHYPO_G00129270 PE=4 SV=1)

HSP 1 Score: 96.6709 bits (239), Expect = 7.748e-22
Identity = 52/127 (40.94%), Postives = 78/127 (61.42%), Query Frame = 2 
Query:   35 YLVSNSYLGILFIHLHIIQIKTLFFVKSNMLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGD-LALHGLRE-KSEGDSLEYF 409
            +L+  S +G +++   + +       K  +LCGGTT A++ TEE  KI  ++KP  EE+ G K + F   S KSQ+VAG NYF K+H+G    VH+R++K LP  G+ L LHG++  K+  D +EYF
Sbjct:    6 WLLCCSDVGRVWMWFCLTK-------KMPLLCGGTTEAKDATEEVQKICDEMKPHAEEKAGRKFDVFTAKSYKSQVVAGTNYFIKVHVGGDDFVHLRIYKTLPHAGEKLTLHGIQTPKAHQDPIEYF 125
[Close]
BLAST of Cystatin vs. TrEMBL
Match: A0A076FGM2 (Cystatin (Fragment) OS=Paracyclopina nana OX=565004 PE=2 SV=1)

HSP 1 Score: 93.9745 bits (232), Expect = 3.261e-21
Identity = 45/96 (46.88%), Postives = 66/96 (68.75%), Query Frame = 2 
Query:  125 LCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGDLALHGLR-EKSEGDSLEYF 409
            LCGGT++ +  TEE   +   +KP +E +LG  C +F+  S KSQ+VAG NYF K+H+G+ KHVH+R++K L  QG++ LH  + +KS  D +EYF
Sbjct:    3 LCGGTSDVKAITEEVTAVCNKVKPDLEAKLGVACASFEPKSYKSQVVAGTNYFVKVHVGDDKHVHLRIYKDL--QGNVELHSHQADKSHEDPIEYF 96
[Close]
BLAST of Cystatin vs. TrEMBL
Match: A0A3B4CQU0 (Cystatin 14a, tandem duplicate 1 OS=Pygocentrus nattereri OX=42514 PE=3 SV=1)

HSP 1 Score: 92.8189 bits (229), Expect = 1.158e-20
Identity = 48/98 (48.98%), Postives = 65/98 (66.33%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGD-LALHGLR-EKSEGDSLEYF 409
            MLCGGTT A+   +E  +I  ++KP  EE+ G K E F   S KSQ+VAG NYF K+H+G  + +H+RV+K LP  G+ L LHGL+  K+  D +EYF
Sbjct:    3 MLCGGTTEAKEADDEVQRICNEVKPHAEEKAGKKFEVFTAKSYKSQLVAGTNYFIKVHVGGDEFLHLRVYKMLPYAGEKLELHGLQTSKAHHDPIEYF 100
[Close]
BLAST of Cystatin vs. Ensembl Cavefish
Match: cst14a.1 (cystatin-B [Source:NCBI gene;Acc:103046569])

HSP 1 Score: 78.9518 bits (193), Expect = 9.934e-19
Identity = 42/98 (42.86%), Postives = 59/98 (60.20%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQ-GDLALHGLR-EKSEGDSLEYF 409
            MLCGGTT  +   EE  KI  ++K   E++ G   + F   S K+Q+VAG NYF K+H+G  + VH+RV+K LP   G L L  ++  K+  D +EYF
Sbjct:    3 MLCGGTTEEKEANEEVQKICDEMKTHAEQKAGKTFDVFSARSYKTQLVAGTNYFVKVHVGGEEFVHLRVYKMLPHYGGKLELTSMQSSKAHHDPIEYF 100
[Close]
BLAST of Cystatin vs. Ensembl Nematostella
Match: EDO38843 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBS4])

HSP 1 Score: 83.5741 bits (205), Expect = 6.076e-21
Identity = 42/99 (42.42%), Postives = 62/99 (62.63%), Query Frame = 2 
Query:  125 LCGGTTNARNPTEEEIKILLD-IKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGD-LALHG-LREKSEGDSLEYFD 412
            LCGG +      +EE++ + D IKPK E   G K + F     K+Q+VAG N+F K+H+GN  +VH+RV++ LP  G+ L L   L +KSE D ++YF+
Sbjct:    3 LCGGVSKELKEADEEVQAICDKIKPKAEVESGRKFDVFKATHYKTQVVAGTNFFIKVHVGNNNYVHLRVYRTLPCAGETLKLSAMLVDKSESDEVQYFE 101
[Close]
BLAST of Cystatin vs. Ensembl Nematostella
Match: EDO38753 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SC06])

HSP 1 Score: 83.1889 bits (204), Expect = 9.236e-21
Identity = 42/100 (42.00%), Postives = 59/100 (59.00%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLP--GQGDLALHGLREKSEGDSLEYFDK 415
            M CG  +  +   EE   I   +K  VE + G K  +F+    +SQ+VAG NYF K+H+GNG ++H+RVF+ LP  GQ    +  L +K+E D L YFDK
Sbjct:    1 MACGAASVVQEANEEIQAICDQMKVHVEAKCGRKFGSFEATHFRSQVVAGTNYFIKVHVGNGSYLHLRVFQTLPFAGQNLELVAMLMDKTEDDELNYFDK 100
[Close]
BLAST of Cystatin vs. Ensembl Medaka
Match: cst14a.2 (cystatin-B [Source:NCBI gene;Acc:101163695])

HSP 1 Score: 69.3218 bits (168), Expect = 3.959e-15
Identity = 37/97 (38.14%), Postives = 56/97 (57.73%), Query Frame = 2 
Query:  125 LCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQ-GDLALHGLRE-KSEGDSLEYF 409
            +CGG T  ++      +I   IK  VE++ G     F   S K+QIVAG NYF K+H+G   +VHIR+++ LP   G+L L  ++  K+  + +EYF
Sbjct:    3 MCGGLTEVKDADASVQQICDQIKAHVEQKAGANFGVFTAKSYKTQIVAGTNYFIKVHVGGDDYVHIRIWQKLPCYGGELELTNIQHPKTHSEPIEYF 99
[Close]
BLAST of Cystatin vs. Ensembl Medaka
Match: ENSORLT00000011596.2 (cystatin-B-like [Source:NCBI gene;Acc:101163934])

HSP 1 Score: 63.1586 bits (152), Expect = 8.181e-13
Identity = 33/95 (34.74%), Postives = 54/95 (56.84%), Query Frame = 2 
Query:  131 GGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQ-GDLALHGLRE-KSEGDSLEYF 409
            GG T+ +       +I   +K  VE++ G     F   S K+Q+VAG NYF K+H+G   +VH+R+++ LP   G+L L  ++  K+  + +EYF
Sbjct:    5 GGLTDVKEADASVQQICDQVKAHVEQKAGANFGVFTAKSYKTQVVAGTNYFIKVHVGGDDYVHVRIWQKLPCYGGELELANIQHPKTHSEPIEYF 99
[Close]
BLAST of Cystatin vs. Ensembl Medaka
Match: ENSORLT00000028155.1 (cystatin-B [Source:NCBI gene;Acc:101164190])

HSP 1 Score: 63.1586 bits (152), Expect = 1.630e-12
Identity = 30/76 (39.47%), Postives = 45/76 (59.21%), Query Frame = 2 
Query:  125 LCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQG 352
            LCGG T  R   EE  KI   +K + E   G K  +F  +S K+Q++AG++Y  K+H+G  K+VH++V+   P  G
Sbjct:   36 LCGGLTETRKADEEIQKICNQVKDRAEGMAGKKFNSFVAISYKTQVMAGISYSIKVHVGGDKYVHVQVWHKRPWNG 111
[Close]
BLAST of Cystatin vs. Ensembl Medaka
Match: ENSORLT00000011612.2 (leukocyte cysteine proteinase inhibitor 1-like [Source:NCBI gene;Acc:101164440])

HSP 1 Score: 49.2914 bits (116), Expect = 9.951e-8
Identity = 28/77 (36.36%), Postives = 42/77 (54.55%), Query Frame = 2 
Query:  134 GTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIH--LGNGKHVHIRVFKPLPGQGDL 358
            G T  R   E+  KI   +K + EE  G + + F  +S +SQ+VAG+ Y+ K+   +G    VHI VF+ L G  +L
Sbjct:    6 GLTETRVANEDIQKICNLVKDRAEEMAGKRFDLFGAISYRSQVVAGIMYYIKVRTVIGKENFVHIEVFEDLEGNTEL 82
[Close]
BLAST of Cystatin vs. Planmine SMEST
Match: SMESG000034246.1 (SMESG000034246.1)

HSP 1 Score: 204.912 bits (520), Expect = 4.317e-68
Identity = 99/99 (100.00%), Postives = 99/99 (100.00%), Query Frame = 2 
Query:  122 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGDLALHGLREKSEGDSLEYFDKD 418
            MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGDLALHGLREKSEGDSLEYFDKD
Sbjct:    1 MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGDLALHGLREKSEGDSLEYFDKD 99
[Close]
BLAST of Cystatin vs. Planmine SMEST
Match: SMESG000026736.1 (SMESG000026736.1)

HSP 1 Score: 43.5134 bits (101), Expect = 9.838e-6
Identity = 20/87 (22.99%), Postives = 48/87 (55.17%), Query Frame = 2 
Query:  149 RNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAGVNYFAKIHLGNGKHVHIRVFKPLPGQGDLALHGLREKSEGDSLEYF 409
            RNP+EEE ++L++I   + +    + + F +++++S I   + + AKI + + + +H++ + P   +  +AL  ++     + L  F
Sbjct:    8 RNPSEEETRMLMEISSDIAKNRELEAKIFKVITVRSPIHEELFHLAKIQVDSDEFIHVQAYFPNRTRQKVALDSIKPALRDEELTIF 94
The following BLAST results are available for this feature:
BLAST of Cystatin vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3
Match NameE-valueIdentityDescription
CSTA7.409e-1637.76cystatin A [Source:HGNC Symbol;Acc:HGNC:2481][more]
CSTB1.070e-1537.76cystatin B [Source:HGNC Symbol;Acc:HGNC:2482][more]
CSTB2.572e-736.67cystatin B [Source:HGNC Symbol;Acc:HGNC:2482][more]
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BLAST of Cystatin vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cystatin vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cystatin vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cst14a.22.193e-2142.86cystatin 14a, tandem duplicate 2 [Source:ZFIN;Acc:... [more]
cst14a.11.203e-1941.84cystatin 14a, tandem duplicate 1 [Source:ZFIN;Acc:... [more]
cst14a.11.203e-1941.84cystatin 14a, tandem duplicate 1 [Source:ZFIN;Acc:... [more]
cst14b.12.962e-1538.95cystatin 14b, tandem duplicate 1 [Source:NCBI gene... [more]
cst14b.23.091e-830.38cystatin 14b, tandem duplicate 2 [Source:ZFIN;Acc:... [more]
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BLAST of Cystatin vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ercc6l22.159e-1636.36excision repair cross-complementation group 6 like... [more]
ercc6l24.276e-1638.38excision repair cross-complementation group 6 like... [more]
ercc6l23.978e-1434.04excision repair cross-complementation group 6 like... [more]
ENSXETT00000037497.15.575e-832.39cystatin-A5-like [Source:NCBI gene;Acc:105946733][more]
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BLAST of Cystatin vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Csta17.408e-1944.33cystatin A1 [Source:MGI Symbol;Acc:MGI:3524930][more]
Cstdc42.001e-1742.27cystatin domain containing 4 [Source:MGI Symbol;Ac... [more]
Csta36.939e-1739.18cystatin A family member 3 [Source:MGI Symbol;Acc:... [more]
Csta21.301e-1540.21cystatin A family member 2 [Source:MGI Symbol;Acc:... [more]
Csta21.301e-1540.21cystatin A family member 2 [Source:MGI Symbol;Acc:... [more]
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BLAST of Cystatin vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P56567|CYTA_MOUSE5.182e-1844.33Cystatin-A OS=Mus musculus OX=10090 GN=Csta PE=3 S... [more]
sp|J7FQE8|CYTB_OPLFA8.849e-1841.41Cystatin-B OS=Oplegnathus fasciatus OX=163134 PE=2... [more]
sp|P35479|CPI1_PIG5.361e-1742.86Leukocyte cysteine proteinase inhibitor 1 OS=Sus s... [more]
sp|Q28988|CYTA1_PIG7.203e-1741.84Cystatin-A1 OS=Sus scrofa OX=9823 PE=1 SV=1[more]
sp|B2Z449|CYTB_PAROL1.993e-1643.56Cystatin-B OS=Paralichthys olivaceus OX=8255 PE=1 ... [more]
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BLAST of Cystatin vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A267E0R76.716e-2649.52Cystatin domain-containing protein (Fragment) OS=M... [more]
A0A267DNU01.473e-2550.00Cystatin domain-containing protein (Fragment) OS=M... [more]
A0A5N5KS337.748e-2240.94Uncharacterized protein OS=Pangasianodon hypophtha... [more]
A0A076FGM23.261e-2146.88Cystatin (Fragment) OS=Paracyclopina nana OX=56500... [more]
A0A3B4CQU01.158e-2048.98Cystatin 14a, tandem duplicate 1 OS=Pygocentrus na... [more]
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BLAST of Cystatin vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cst14a.19.934e-1942.86cystatin-B [Source:NCBI gene;Acc:103046569][more]
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BLAST of Cystatin vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cystatin vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cystatin vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO388436.076e-2142.42Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO387539.236e-2142.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Cystatin vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
cst14a.23.959e-1538.14cystatin-B [Source:NCBI gene;Acc:101163695][more]
ENSORLT00000011596.28.181e-1334.74cystatin-B-like [Source:NCBI gene;Acc:101163934][more]
ENSORLT00000028155.11.630e-1239.47cystatin-B [Source:NCBI gene;Acc:101164190][more]
ENSORLT00000011612.29.951e-836.36leukocyte cysteine proteinase inhibitor 1-like [So... [more]
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BLAST of Cystatin vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000034246.14.317e-68100.00SMESG000034246.1[more]
SMESG000026736.19.838e-622.99SMESG000026736.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30024754 ID=SMED30024754|Name=Cystatin|organism=Schmidtea mediterranea sexual|type=transcript|length=693bp
CTTTATTCATATTAATTAATAGTGTTTTGTACTATACCTTGTTTCAAACA
GTTATTTAGGAATTTTGTTTATTCATTTACATATTATTCAAATCAAAACA
TTATTCTTTGTAAAATCAAACATGTTATGTGGTGGAACTACCAATGCTAG
AAATCCTACGGAAGAAGAAATTAAAATCTTACTAGATATAAAACCTAAAG
TTGAAGAACGTCTAGGTCACAAGTGTGAAACTTTTGATATTTTGTCATTG
AAATCTCAAATTGTAGCTGGAGTAAATTATTTTGCCAAGATTCATCTCGG
TAATGGTAAACATGTCCATATTAGAGTTTTTAAACCTCTACCGGGACAAG
GAGATTTAGCTTTGCATGGATTGCGTGAAAAGTCTGAAGGAGATTCATTA
GAATATTTCGATAAAGATTAAGTTGGGTTTTAAACCAAATTTCTGATTTT
GGCTCTTAATTAAATATTTATTTTATATGAAATTAAATTTTAGAGTTTGA
TCGATTTATAGACATTATTAAATTCAAGTGTTTTGACACATGCAACGCTT
AGTTAAATAAAAGAAAAATTAGTGTGGGTGTATGTAGGATGCTTTAATCA
TTATTGGTATGCTCTGAATACATTGCCATTTATCCCCTCTTATTAATTTC
ATATTTTAAAAATTATTGGAGGCTTTTGAATACATGTAAAAAT
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protein sequence of SMED30024754-orf-1

>SMED30024754-orf-1 ID=SMED30024754-orf-1|Name=SMED30024754-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=100bp
MLCGGTTNARNPTEEEIKILLDIKPKVEERLGHKCETFDILSLKSQIVAG
VNYFAKIHLGNGKHVHIRVFKPLPGQGDLALHGLREKSEGDSLEYFDKD*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000020protonephridia
PLANA:0000026gut
PLANA:0000070intestinal phagocyte
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR001713Prot_inh_stefin
IPR000010Cystatin_dom
Vocabulary: molecular function
TermDefinition
GO:0004866endopeptidase inhibitor activity
GO:0004869cysteine-type endopeptidase inhibitor activity
Vocabulary: cellular component
TermDefinition
GO:0005622intracellular
Vocabulary: biological process
TermDefinition
GO:0010951negative regulation of endopeptidase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001713Proteinase inhibitor I25A, stefinPRINTSPR00295STEFINAcoord: 27..46
score: 33.33
coord: 47..66
score: 48.06
coord: 4..23
score: 29.17
IPR001713Proteinase inhibitor I25A, stefinPANTHERPTHR11414CYSTATIN FAMILY MEMBERcoord: 1..96
IPR000010Cystatin domainSMARTSM00043CY_4coord: 1..96
e-value: 0.0088
score: 21.9
IPR000010Cystatin domainPFAMPF00031Cystatincoord: 4..82
e-value: 1.4E-6
score: 28.5
NoneNo IPR availableGENE3DG3DSA:3.10.450.10coord: 1..96
e-value: 7.8E-26
score: 91.9
NoneNo IPR availableSUPERFAMILYSSF54403Cystatin/monellincoord: 1..80