ribose-5-phosphate isomerase
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30024740 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of ribose-5-phosphate isomerase vs. Ensembl Human
Match: RPIA (ribose 5-phosphate isomerase A [Source:HGNC Symbol;Acc:HGNC:10297]) HSP 1 Score: 51.6026 bits (122), Expect = 7.065e-7 Identity = 27/61 (44.26%), Postives = 39/61 (63.93%), Query Frame = 1 Query: 43 MSLNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERL---VNEEKLKVSCVPTSFQA 216 MS E KK A A++ +V+N Q +G GS STI +++R+ V +E L + C+PTSFQA Sbjct: 75 MSKAEEAKKLAGRAAVENHVRNNQVLGIGSGSTIVHAVQRIAERVKQENLNLVCIPTSFQA 135
BLAST of ribose-5-phosphate isomerase vs. Ensembl Zebrafish
Match: rpia (ribose 5-phosphate isomerase A (ribose 5-phosphate epimerase) [Source:ZFIN;Acc:ZDB-GENE-041114-24]) HSP 1 Score: 65.0846 bits (157), Expect = 1.348e-11 Identity = 32/63 (50.79%), Postives = 43/63 (68.25%), Query Frame = 1 Query: 37 FLMSLNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERL---VNEEKLKVSCVPTSFQA 216 + + E KK AAY A+D ++QN Q IG GS STI ++++RL V +EKL + CVPTSFQA Sbjct: 37 YCSRMAEEAKKLAAYAAVDNHIQNNQVIGVGSGSTIVYAVDRLAEKVRQEKLNIVCVPTSFQA 99
BLAST of ribose-5-phosphate isomerase vs. Ensembl Xenopus
Match: ccdc65 (coiled-coil domain containing 65 [Source:Xenbase;Acc:XB-GENE-1002732]) HSP 1 Score: 58.5362 bits (140), Expect = 1.591e-9 Identity = 29/71 (40.85%), Postives = 44/71 (61.97%), Query Frame = 1 Query: 13 IVQILIVNFLMSLNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERL---VNEEKLKVSCVPTSFQA 216 ++Q ++ + + E K+ A + A+D +V+N Q +G GS STI ++ RL V +E L V CVPTSFQA Sbjct: 1 MIQRRLLTTIRRMTEEAKRLAGWAAVDNHVKNNQALGIGSGSTIVHAVNRLAERVKQENLNVVCVPTSFQA 71
BLAST of ribose-5-phosphate isomerase vs. Ensembl Xenopus
Match: ccdc65 (coiled-coil domain containing 65 [Source:Xenbase;Acc:XB-GENE-1002732]) HSP 1 Score: 56.225 bits (134), Expect = 1.218e-8 Identity = 28/59 (47.46%), Postives = 38/59 (64.41%), Query Frame = 1 Query: 49 LNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERL---VNEEKLKVSCVPTSFQA 216 + E K+ A + A+D +V+N Q +G GS STI ++ RL V +E L V CVPTSFQA Sbjct: 1 MTEEAKRLAGWAAVDNHVKNNQALGIGSGSTIVHAVNRLAERVKQENLNVVCVPTSFQA 59
BLAST of ribose-5-phosphate isomerase vs. Ensembl Mouse
Match: Rpia (ribose 5-phosphate isomerase A [Source:MGI Symbol;Acc:MGI:103254]) HSP 1 Score: 52.7582 bits (125), Expect = 2.032e-7 Identity = 27/61 (44.26%), Postives = 41/61 (67.21%), Query Frame = 1 Query: 43 MSLNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERL---VNEEKLKVSCVPTSFQA 216 MS E KK A++ A++ +V+N Q +G GS STI +++R+ V +E L + C+PTSFQA Sbjct: 68 MSKAEEAKKLASHTAVENHVKNNQVLGIGSGSTIVHAVQRIAERVKQENLDLICIPTSFQA 128
BLAST of ribose-5-phosphate isomerase vs. UniProt/SwissProt
Match: sp|Q3T186|RPIA_BOVIN (Ribose-5-phosphate isomerase (Fragment) OS=Bos taurus OX=9913 GN=RPIA PE=2 SV=2) HSP 1 Score: 53.9138 bits (128), Expect = 4.733e-7 Identity = 28/61 (45.90%), Postives = 40/61 (65.57%), Query Frame = 1 Query: 43 MSLNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERL---VNEEKLKVSCVPTSFQA 216 MS E KK A A++ +V+N Q +G GS STI +++R+ V +E LK+ C+PTSFQA Sbjct: 29 MSKAEEAKKLAGRAAVENHVRNNQVLGIGSGSTIVHAVQRIAERVEQENLKLVCIPTSFQA 89
BLAST of ribose-5-phosphate isomerase vs. UniProt/SwissProt
Match: sp|Q551C2|RPIA_DICDI (Ribose-5-phosphate isomerase OS=Dictyostelium discoideum OX=44689 GN=rpiA PE=3 SV=1) HSP 1 Score: 53.5286 bits (127), Expect = 4.815e-7 Identity = 33/69 (47.83%), Postives = 47/69 (68.12%), Query Frame = 1 Query: 43 MSLNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERLVNEEKLK-VSCVPTSFQA--FLIWMGFE 240 MSL+ KK AAY A+D +V++G +IG GS STI ++++R + E LK V CVPTSFQ+ ++ G E Sbjct: 1 MSLDNC-KKVAAYKAVDDFVKDGCKIGIGSGSTIKYAVDR-IKELGLKNVICVPTSFQSTQLIVEAGLE 67
BLAST of ribose-5-phosphate isomerase vs. UniProt/SwissProt
Match: sp|P47968|RPIA_MOUSE (Ribose-5-phosphate isomerase OS=Mus musculus OX=10090 GN=Rpia PE=1 SV=2) HSP 1 Score: 52.7582 bits (125), Expect = 1.421e-6 Identity = 27/61 (44.26%), Postives = 41/61 (67.21%), Query Frame = 1 Query: 43 MSLNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERL---VNEEKLKVSCVPTSFQA 216 MS E KK A++ A++ +V+N Q +G GS STI +++R+ V +E L + C+PTSFQA Sbjct: 68 MSKAEEAKKLASHTAVENHVKNNQVLGIGSGSTIVHAVQRIAERVKQENLDLICIPTSFQA 128
BLAST of ribose-5-phosphate isomerase vs. UniProt/SwissProt
Match: sp|A2TLM1|RPIA_PIG (Ribose-5-phosphate isomerase OS=Sus scrofa OX=9823 GN=RPIA PE=2 SV=1) HSP 1 Score: 51.6026 bits (122), Expect = 3.387e-6 Identity = 27/61 (44.26%), Postives = 39/61 (63.93%), Query Frame = 1 Query: 43 MSLNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERL---VNEEKLKVSCVPTSFQA 216 MS E KK A A++ +V+N Q +G GS STI +++R+ V +E L + C+PTSFQA Sbjct: 71 MSKAEEAKKLAGRAAVENHVRNNQVLGIGSGSTIVHAVQRIAERVKQENLNLICIPTSFQA 131
BLAST of ribose-5-phosphate isomerase vs. UniProt/SwissProt
Match: sp|P49247|RPIA_HUMAN (Ribose-5-phosphate isomerase OS=Homo sapiens OX=9606 GN=RPIA PE=1 SV=3) HSP 1 Score: 51.6026 bits (122), Expect = 3.393e-6 Identity = 27/61 (44.26%), Postives = 39/61 (63.93%), Query Frame = 1 Query: 43 MSLNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERL---VNEEKLKVSCVPTSFQA 216 MS E KK A A++ +V+N Q +G GS STI +++R+ V +E L + C+PTSFQA Sbjct: 75 MSKAEEAKKLAGRAAVENHVRNNQVLGIGSGSTIVHAVQRIAERVKQENLNLVCIPTSFQA 135
BLAST of ribose-5-phosphate isomerase vs. TrEMBL
Match: A0A1A8BIU4 (Ribose 5-phosphate isomerase A (Ribose 5-phosphate epimerase) OS=Nothobranchius kadleci OX=1051664 GN=RPIA PE=3 SV=1) HSP 1 Score: 67.781 bits (164), Expect = 2.169e-9 Identity = 35/59 (59.32%), Postives = 42/59 (71.19%), Query Frame = 1 Query: 49 LNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERL---VNEEKLKVSCVPTSFQA 216 + E KK AAY A+D YVQN Q IG GS STI ++++RL V +EKL V CVPTSFQA Sbjct: 1 MAEEAKKLAAYAAVDNYVQNNQVIGVGSGSTIVYAVDRLAERVRQEKLNVVCVPTSFQA 59
BLAST of ribose-5-phosphate isomerase vs. TrEMBL
Match: A0A1A8KS62 (Ribose 5-phosphate isomerase A (Ribose 5-phosphate epimerase) OS=Nothobranchius kuhntae OX=321403 GN=RPIA PE=3 SV=1) HSP 1 Score: 67.781 bits (164), Expect = 2.169e-9 Identity = 35/59 (59.32%), Postives = 42/59 (71.19%), Query Frame = 1 Query: 49 LNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERL---VNEEKLKVSCVPTSFQA 216 + E KK AAY A+D YVQN Q IG GS STI ++++RL V +EKL V CVPTSFQA Sbjct: 1 MAEEAKKLAAYAAVDNYVQNNQVIGVGSGSTIVYAVDRLAERVRQEKLNVVCVPTSFQA 59
BLAST of ribose-5-phosphate isomerase vs. TrEMBL
Match: A0A1A8S504 (Ribose 5-phosphate isomerase A (Ribose 5-phosphate epimerase) OS=Nothobranchius rachovii OX=451742 GN=RPIA PE=3 SV=1) HSP 1 Score: 67.781 bits (164), Expect = 2.211e-9 Identity = 35/59 (59.32%), Postives = 42/59 (71.19%), Query Frame = 1 Query: 49 LNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERL---VNEEKLKVSCVPTSFQA 216 + E KK AAY A+D YVQN Q IG GS STI ++++RL V +EKL V CVPTSFQA Sbjct: 1 MAEEAKKLAAYAAVDNYVQNNQVIGVGSGSTIVYAVDRLAERVRQEKLNVVCVPTSFQA 59
BLAST of ribose-5-phosphate isomerase vs. TrEMBL
Match: A0A1A8L0V8 (Ribose 5-phosphate isomerase A (Ribose 5-phosphate epimerase) OS=Nothobranchius pienaari OX=704102 GN=RPIA PE=3 SV=1) HSP 1 Score: 67.781 bits (164), Expect = 2.211e-9 Identity = 35/59 (59.32%), Postives = 42/59 (71.19%), Query Frame = 1 Query: 49 LNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERL---VNEEKLKVSCVPTSFQA 216 + E KK AAY A+D YVQN Q IG GS STI ++++RL V +EKL V CVPTSFQA Sbjct: 1 MAEEAKKLAAYAAVDNYVQNNQVIGVGSGSTIVYAVDRLAERVRQEKLNVVCVPTSFQA 59
BLAST of ribose-5-phosphate isomerase vs. TrEMBL
Match: A0A1A8B7J9 (Ribose 5-phosphate isomerase A (Ribose 5-phosphate epimerase) OS=Nothobranchius furzeri OX=105023 GN=RPIA PE=3 SV=1) HSP 1 Score: 67.781 bits (164), Expect = 2.254e-9 Identity = 35/59 (59.32%), Postives = 42/59 (71.19%), Query Frame = 1 Query: 49 LNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERL---VNEEKLKVSCVPTSFQA 216 + E KK AAY A+D YVQN Q IG GS STI ++++RL V +EKL V CVPTSFQA Sbjct: 1 MAEEAKKLAAYAAVDNYVQNNQVIGVGSGSTIVYAVDRLAERVRQEKLNVVCVPTSFQA 59
BLAST of ribose-5-phosphate isomerase vs. Ensembl Cavefish
Match: rpia (ribose-5-phosphate isomerase [Source:NCBI gene;Acc:103042087]) HSP 1 Score: 65.4698 bits (158), Expect = 9.854e-12 Identity = 32/59 (54.24%), Postives = 43/59 (72.88%), Query Frame = 1 Query: 49 LNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERL---VNEEKLKVSCVPTSFQA 216 + E KK AAY A+D ++QN Q +G GS STI ++++RL V +EKLK+ CVPTSFQA Sbjct: 60 MAEEAKKLAAYAAVDNHIQNNQIVGVGSGSTIVYAVDRLAERVRQEKLKIICVPTSFQA 118
BLAST of ribose-5-phosphate isomerase vs. Ensembl Nematostella
Match: EDO31708 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX61]) HSP 1 Score: 67.3958 bits (163), Expect = 3.477e-13 Identity = 33/57 (57.89%), Postives = 45/57 (78.95%), Query Frame = 1 Query: 55 EIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERL---VNEEKLKVSCVPTSFQA 216 E GKKAAA +A++K+V+NG +G GS ST+ +++ERL V +EKL+V CVPTSFQA Sbjct: 2 EAGKKAAAVYAVNKFVKNGHVLGIGSGSTVVYAVERLAKRVMKEKLEVVCVPTSFQA 58
BLAST of ribose-5-phosphate isomerase vs. Ensembl Medaka
Match: rpia (ribose 5-phosphate isomerase A [Source:NCBI gene;Acc:101166762]) HSP 1 Score: 63.929 bits (154), Expect = 2.488e-11 Identity = 32/60 (53.33%), Postives = 42/60 (70.00%), Query Frame = 1 Query: 46 SLNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERL---VNEEKLKVSCVPTSFQA 216 + E KK AAY A+D +VQN Q +G GS STI ++++RL V +EKL + CVPTSFQA Sbjct: 36 GMAEEAKKLAAYAAVDNHVQNNQVVGVGSGSTIVYAVDRLAERVMQEKLNIVCVPTSFQA 95
BLAST of ribose-5-phosphate isomerase vs. Planmine SMEST
Match: SMESG000004984.1 (SMESG000004984.1) HSP 1 Score: 98.5969 bits (244), Expect = 5.192e-24 Identity = 51/82 (62.20%), Postives = 62/82 (75.61%), Query Frame = 1 Query: 43 MSLNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFSLERLVN---EEKLKVSCVPTSFQAFLIWMGFECLSIALFSDFHFQ 279 MSL EIGKKAAAYFAIDKYVQNGQ+IG GS STITF++ERL + EEKL VSC PTSFQA L+ + ++ I+L ++ Sbjct: 1 MSLKEIGKKAAAYFAIDKYVQNGQKIGIGSGSTITFAVERLAHKVIEEKLTVSCAPTSFQAKLLILEYKLPLISLEENYELD 82 The following BLAST results are available for this feature:
BLAST of ribose-5-phosphate isomerase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 1
BLAST of ribose-5-phosphate isomerase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of ribose-5-phosphate isomerase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of ribose-5-phosphate isomerase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 1
BLAST of ribose-5-phosphate isomerase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 2
BLAST of ribose-5-phosphate isomerase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 1
BLAST of ribose-5-phosphate isomerase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of ribose-5-phosphate isomerase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of ribose-5-phosphate isomerase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 1
BLAST of ribose-5-phosphate isomerase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of ribose-5-phosphate isomerase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of ribose-5-phosphate isomerase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of ribose-5-phosphate isomerase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 1
BLAST of ribose-5-phosphate isomerase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30024740 ID=SMED30024740|Name=ribose-5-phosphate isomerase|organism=Schmidtea mediterranea sexual|type=transcript|length=967bpback to top protein sequence of SMED30024740-orf-1 >SMED30024740-orf-1 ID=SMED30024740-orf-1|Name=SMED30024740-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=117bp PALVIVQILIVNFLMSLNEIGKKAAAYFAIDKYVQNGQQIGTGSVSTITFback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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