Pyruvate carboxylase

Overview


Name	Pyruvate carboxylase
Smed ID	SMED30024713
Length (bp)	3655

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Pyruvate carboxylase (SMED30024713) t-SNE clustered cells

Violin plots show distribution of expression levels for Pyruvate carboxylase (SMED30024713) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Pyruvate carboxylase (SMED30024713) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Pyruvate carboxylase (SMED30024713) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30024713

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 8

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30024713	h1SMcG0016686	dd_Smed_v4_2393_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30024713	h1SMcG0016686	dd_Smed_v4_2393_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30024713	h1SMcG0016686	dd_Smed_v4_2393_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parapharyngeal region	SMED30024713	h1SMcG0016686	dd_Smed_v4_2393_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30024713	h1SMcG0016686	dd_Smed_v4_2393_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30024713	h1SMcG0016686	dd_Smed_v4_2393_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30024713	h1SMcG0016686	dd_Smed_v4_2393_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30024713	h1SMcG0016686	dd_Smed_v4_2393_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

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Homology

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BLAST of Pyruvate carboxylase vs. Ensembl Human
Match: PC (pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:8636])

HSP 1 Score: 1541.94 bits (3991), Expect = 0.000e+0
Identity = 743/1149 (64.66%), Postives = 922/1149 (80.24%), Query Frame = 3

Query:  135 LTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            L  K I+KV+VANRGEIAIRVFRAC E+GIR+VAIYSEQDT QMHR KADE+YLIG+GL PV AYL+I +IIK++K ++VDA+HPGYGFLSER+DFA AC +AG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI +  EA EF   YG PII KAAYGGGGRGMRVV   E L EN+TRA SEALAAFGNG +F+EKFIE+PRHIEVQILGD++GN +HL+ERDCS+QRRHQK+VEIAPA +L   +R ++ SD+VKLAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +QI +AEG+SLP+LGL QE IR  G AIQCR+TTEDPAR FQPD+GR+EVFRSGEGMGIRLD+ASAF GA+ISP+YDSLL+KVIAH  +   A  KM R+L EFRVRGVKTNI FL NVL N++FL G+VDT FIDE+P LFQ + +QNRAQKLL YLG +MVNGP T +     PS  +P +P  PI    P G+RDIL++ GP+ FA+AVR HPG L+MDTTFRDAHQSLLATRVRT+D+ +I+P+VA NF  LFS+ENWGGATFDV+MRFL ECPW RL+ LR+LIPNIPFQMLLRGANAVGYTNYPDN+V+KFC++A ++GMD+FRVFD LNYLPN+++GM+A   AGGVVEA+  Y+GD+ DP++TKY+L YY+ LA++LV+ G HIL IKDMAG+LKP A  +L+  LR ++PD+P+H+H+HDT+GAGVA MLA A++G D+VD A DSMSG+TSQPSMGA+VAC + TPLDT + +E+++ YS YWE AR LY  F+CT TM+SGN+DVY N+IPGGQYTNL FQ+ S+GL  +F+EVK+ Y  AN +LGD+IKVTPSSKIVGDLAQFMVQN +       +A+ELS P+SV+EF QG++G P+GGFPE  RSKV+K+   + GRPG  L   D +A + EL D    +   +D++S A+YP VF  F+ F   FGP+  L TR+FL GP+IAEE  V+LE+GKTLHIK LA+SD+  +G R+VFFELNGQLRS+ + D +A K +   PKA K V+G +G+PMPG+V+++KV  G  V KGQ LC++SAMKME  V SP++G V+ VHV   M +EG+DL++EIE
Sbjct:   32 LEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDR-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIAFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPP-PAGFRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE 1178

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Query:  135 LTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            L  K I+KV+VANRGEIAIRVFRAC E+GIR+VAIYSEQDT QMHR KADE+YLIG+GL PV AYL+I +IIK++K ++VDA+HPGYGFLSER+DFA AC +AG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI +  EA EF   YG PII KAAYGGGGRGMRVV   E L EN+TRA SEALAAFGNG +F+EKFIE+PRHIEVQILGD++GN +HL+ERDCS+QRRHQK+VEIAPA +L   +R ++ SD+VKLAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +QI +AEG+SLP+LGL QE IR  G AIQCR+TTEDPAR FQPD+GR+EVFRSGEGMGIRLD+ASAF GA+ISP+YDSLL+KVIAH  +   A  KM R+L EFRVRGVKTNI FL NVL N++FL G+VDT FIDE+P LFQ + +QNRAQKLL YLG +MVNGP T +     PS  +P +P  PI    P G+RDIL++ GP+ FA+AVR HPG L+MDTTFRDAHQSLLATRVRT+D+ +I+P+VA NF  LFS+ENWGGATFDV+MRFL ECPW RL+ LR+LIPNIPFQMLLRGANAVGYTNYPDN+V+KFC++A ++GMD+FRVFD LNYLPN+++GM+A   AGGVVEA+  Y+GD+ DP++TKY+L YY+ LA++LV+ G HIL IKDMAG+LKP A  +L+  LR ++PD+P+H+H+HDT+GAGVA MLA A++G D+VD A DSMSG+TSQPSMGA+VAC + TPLDT + +E+++ YS YWE AR LY  F+CT TM+SGN+DVY N+IPGGQYTNL FQ+ S+GL  +F+EVK+ Y  AN +LGD+IKVTPSSKIVGDLAQFMVQN +       +A+ELS P+SV+EF QG++G P+GGFPE  RSKV+K+   + GRPG  L   D +A + EL D    +   +D++S A+YP VF  F+ F   FGP+  L TR+FL GP+IAEE  V+LE+GKTLHIK LA+SD+  +G R+VFFELNGQLRS+ + D +A K +   PKA K V+G +G+PMPG+V+++KV  G  V KGQ LC++SAMKME  V SP++G V+ VHV   M +EG+DL++EIE
Sbjct:   32 LEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDR-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIAFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPP-PAGFRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE 1178

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Query:  135 LTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            L  K I+KV+VANRGEIAIRVFRAC E+GIR+VAIYSEQDT QMHR KADE+YLIG+GL PV AYL+I +IIK++K ++VDA+HPGYGFLSER+DFA AC +AG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI +  EA EF   YG PII KAAYGGGGRGMRVV   E L EN+TRA SEALAAFGNG +F+EKFIE+PRHIEVQILGD++GN +HL+ERDCS+QRRHQK+VEIAPA +L   +R ++ SD+VKLAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +QI +AEG+SLP+LGL QE IR  G AIQCR+TTEDPAR FQPD+GR+EVFRSGEGMGIRLD+ASAF GA+ISP+YDSLL+KVIAH  +   A  KM R+L EFRVRGVKTNI FL NVL N++FL G+VDT FIDE+P LFQ + +QNRAQKLL YLG +MVNGP T +     PS  +P +P  PI    P G+RDIL++ GP+ FA+AVR HPG L+MDTTFRDAHQSLLATRVRT+D+ +I+P+VA NF  LFS+ENWGGATFDV+MRFL ECPW RL+ LR+LIPNIPFQMLLRGANAVGYTNYPDN+V+KFC++A ++GMD+FRVFD LNYLPN+++GM+A   AGGVVEA+  Y+GD+ DP++TKY+L YY+ LA++LV+ G HIL IKDMAG+LKP A  +L+  LR ++PD+P+H+H+HDT+GAGVA MLA A++G D+VD A DSMSG+TSQPSMGA+VAC + TPLDT + +E+++ YS YWE AR LY  F+CT TM+SGN+DVY N+IPGGQYTNL FQ+ S+GL  +F+EVK+ Y  AN +LGD+IKVTPSSKIVGDLAQFMVQN +       +A+ELS P+SV+EF QG++G P+GGFPE  RSKV+K+   + GRPG  L   D +A + EL D    +   +D++S A+YP VF  F+ F   FGP+  L TR+FL GP+IAEE  V+LE+GKTLHIK LA+SD+  +G R+VFFELNGQLRS+ + D +A K +   PKA K V+G +G+PMPG+V+++KV  G  V KGQ LC++SAMKME  V SP++G V+ VHV   M +EG+DL++EIE
Sbjct:   32 LEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDR-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIAFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPP-PAGFRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE 1178

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Query:  135 LTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            L  K I+KV+VANRGEIAIRVFRAC E+GIR+VAIYSEQDT QMHR KADE+YLIG+GL PV AYL+I +IIK++K ++VDA+HPGYGFLSER+DFA AC +AG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI +  EA EF   YG PII KAAYGGGGRGMRVV   E L EN+TRA SEALAAFGNG +F+EKFIE+PRHIEVQILGD++GN +HL+ERDCS+QRRHQK+VEIAPA +L   +R ++ SD+VKLAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +QI +AEG+SLP+LGL QE IR  G AIQCR+TTEDPAR FQPD+GR+EVFRSGEGMGIRLD+ASAF GA+ISP+YDSLL+KVIAH  +   A  KM R+L EFRVRGVKTNI FL NVL N++FL G+VDT FIDE+P LFQ + +QNRAQKLL YLG +MVNGP T +     PS  +P +P  PI    P G+RDIL++ GP+ FA+AVR HPG L+MDTTFRDAHQSLLATRVRT+D+ +I+P+VA NF  LFS+ENWGGATFDV+MRFL ECPW RL+ LR+LIPNIPFQMLLRGANAVGYTNYPDN+V+KFC++A ++GMD+FRVFD LNYLPN+++GM+A   AGGVVEA+  Y+GD+ DP++TKY+L YY+ LA++LV+ G HIL IKDMAG+LKP A  +L+  LR ++PD+P+H+H+HDT+GAGVA MLA A++G D+VD A DSMSG+TSQPSMGA+VAC + TPLDT + +E+++ YS YWE AR LY  F+CT TM+SGN+DVY N+IPGGQYTNL FQ+ S+GL  +F+EVK+ Y  AN +LGD+IKVTPSSKIVGDLAQFMVQN +       +A+ELS P+SV+EF QG++G P+GGFPE  RSKV+K+   + GRPG  L   D +A + EL D    +   +D++S A+YP VF  F+ F   FGP+  L TR+FL GP+IAEE  V+LE+GKTLHIK LA+SD+  +G R+VFFELNGQLRS+ + D +A K +   PKA K V+G +G+PMPG+V+++KV  G  V KGQ LC++SAMKME  V SP++G V+ VHV   M +EG+DL++EIE
Sbjct:   32 LEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDR-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIAFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPP-PAGFRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE 1178

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Query:  135 LTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            L  K I+KV+VANRGEIAIRVFRAC E+GIR+VAIYSEQDT QMHR KADE+YLIG+GL PV AYL+I +IIK++K ++VDA+HPGYGFLSER+DFA AC +AG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI +  EA EF   YG PII KAAYGGGGRGMRVV   E L EN+TRA SEALAAFGNG +F+EKFIE+PRHIEVQILGD++GN +HL+ERDCS+QRRHQK+VEIAPA +L   +R ++ SD+VKLAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +QI +AEG+SLP+LGL QE IR  G AIQCR+TTEDPAR FQPD+GR+EVFRSGEGMGIRLD+ASAF GA+ISP+YDSLL+KVIAH  +   A  KM R+L EFRVRGVKTNI FL NVL N++FL G+VDT FIDE+P LFQ + +QNRAQKLL YLG +MVNGP T +     PS  +P +P  PI    P G+RDIL++ GP+ FA+AVR HPG L+MDTTFRDAHQSLLATRVRT+D+ +I+P+VA NF  LFS+ENWGGATFDV+MRFL ECPW RL+ LR+LIPNIPFQMLLRGANAVGYTNYPDN+V+KFC++A ++GMD+FRVFD LNYLPN+++GM+A   AGGVVEA+  Y+GD+ DP++TKY+L YY+ LA++LV+ G HIL IKDMAG+LKP A  +L+  LR ++PD+P+H+H+HDT+GAGVA MLA A++G D+VD A DSMSG+TSQPSMGA+VAC + TPLDT + +E+++ YS YWE AR LY  F+CT TM+SGN+DVY N+IPGGQYTNL FQ+ S+GL  +F+EVK+ Y  AN +LGD+IKVTPSSKIVGDLAQFMVQN +       +A+ELS P+SV+EF QG++G P+GGFPE  RSKV+K+   + GRPG  L   D +A + EL D    +   +D++S A+YP VF  F+ F   FGP+  L TR+FL GP+IAEE  V+LE+GKTLHIK LA+SD+  +G R+VFFELNGQLRS+ + D +A K +   PKA K V+G +G+PMPG+V+++KV  G  V KGQ LC++SAMKME  V SP++G V+ VHV   M +EG+DL++EIE
Sbjct:   32 LEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDR-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIAFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPP-PAGFRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE 1178

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BLAST of Pyruvate carboxylase vs. Ensembl Celegans
Match: pyc-1 (Pyruvate carboxylase 1 [Source:UniProtKB/Swiss-Prot;Acc:O17732])

HSP 1 Score: 1600.49 bits (4143), Expect = 0.000e+0
Identity = 774/1156 (66.96%), Postives = 945/1156 (81.75%), Query Frame = 3

Query:  114 NYKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            NY ++ ++  ++  KV+VANRGEIAIRVFRA  E+   SVAIY+EQD   MHRLKADE+YL+GKGL PVAAYL I +II+ +  H++DAIHPGYGFLSERSDFAAAC  AGI FIGP  DV+ +MGDKV ARQAA++A V VVPG+PGPI T +EA+EF K+YG PIILKAAYGGGGRG+R V +LE + E F R+ SEA AAFG+G +F+EKF+ERPRHIEVQ+LGD  GN VHL+ERDCSVQRRHQK+VEIAPAP L   +R+K+L+DA++LA+ VGY+NAGTVEFL DQ    +YFIEVNARLQVEHTVTE++TGVDLV++QI IAEGKSL +L L+QE I++ G AIQCR+TTEDPA+ FQPDSGR+EVFRSGEGMGIRLDSASAFAG++ISP+YDSL++KVIA A N   A AKM+R+L++FR+RGVKTNIPFL NVL    FL+ SVDTYFIDEHP LFQFK SQNRAQKLL YLG + VNGP T LATDLKP++++P IP  P   + PTG RD+LV+ GP  FA+ VR  PGC+I DTTFRDAHQSLLATRVRTYDMA ISPFVAQ+F  LFSLENWGGATFDVSMRFL ECPWERL+TLRKLIPNIPFQ LLRGANA+GY+NYPDN++YKFC+LAV++GMD+FRVFD LNYLPN++VGM+AV KAGGVVEA+  Y+GD+TD ++ KY+L YYL LAD LVK  AHIL IKDMAGVLKP AA++LIG LR K+PDIPIH+H+HDT+GAGVA ML  A++G D+VD A+DSMSG+TSQPSMGA+VA LQ T  DTGL+L+ I  YS+YWE  R+LY PFEC TTM+SGNADVY ++IPGGQYTNLQFQ+FSLGL  QF+EVK+ Y  AN +LGD+IKVTPSSKIVGDLAQFMVQN +  +TLV++AD+LS PKSV++F QG+VG+P  GFPE LR+KV++    + GRPG++ K  D +A K EL +       ++D+MSY+++P VF EF+ FR+++GPV KL TR+FL G  IAEE+ V++E GKTL I+ LA   +   G REVFF+LNGQ+RS+ +VDKEASK I  RP+A   VRG +G+PMPG+VLE+K+KEGD V K Q L ++SAMKMEM ++SP+ G VK +H     K    DL++E+E
Sbjct:   21 NY-ANGVIKPREFNKVMVANRGEIAIRVFRALTELNKTSVAIYAEQDKNSMHRLKADEAYLVGKGLPPVAAYLTIDQIIETALKHNIDAIHPGYGFLSERSDFAAACQNAGIVFIGPSPDVMARMGDKVAARQAAIEAGVQVVPGTPGPITTADEAVEFAKQYGTPIILKAAYGGGGRGIRRVDKLEEVEEAFRRSYSEAQAAFGDGSLFVEKFVERPRHIEVQLLGDHHGNIVHLYERDCSVQRRHQKVVEIAPAPALPEGVREKILADALRLARHVGYQNAGTVEFLVDQ-KGNYYFIEVNARLQVEHTVTEEITGVDLVQAQIRIAEGKSLDDLKLSQETIQTTGSAIQCRVTTEDPAKGFQPDSGRIEVFRSGEGMGIRLDSASAFAGSVISPHYDSLMVKVIASARNHPNAAAKMIRALKKFRIRGVKTNIPFLLNVLRQPSFLDASVDTYFIDEHPELFQFKPSQNRAQKLLNYLGEVKVNGPTTPLATDLKPAVVSPPIPYIPAGAKPPTGLRDVLVQRGPTEFAKEVRSRPGCMITDTTFRDAHQSLLATRVRTYDMAAISPFVAQSFNGLFSLENWGGATFDVSMRFLHECPWERLQTLRKLIPNIPFQCLLRGANAMGYSNYPDNVIYKFCELAVKNGMDVFRVFDSLNYLPNLLVGMEAVGKAGGVVEAAIAYTGDVTDKSRDKYDLKYYLNLADQLVKAQAHILSIKDMAGVLKPEAAKLLIGALRDKFPDIPIHVHTHDTSGAGVAAMLECAKAGADVVDAAVDSMSGMTSQPSMGAIVASLQGTKHDTGLSLDDISKYSAYWESTRQLYAPFECATTMKSGNADVYKHEIPGGQYTNLQFQAFSLGLGPQFDEVKRMYREANLVLGDIIKVTPSSKIVGDLAQFMVQNNLTRETLVDRADDLSFPKSVVDFMQGNVGQPPYGFPEPLRTKVLRGKPKVDGRPGENAKPVDLDAVKVELEEKHGRTLSEEDVMSYSMFPTVFDEFETFRQQYGPVDKLPTRLFLTGLEIAEEVDVEIESGKTLAIQLLAEGKLNKRGEREVFFDLNGQMRSIFVVDKEASKEIVTRPRALPGVRGHIGAPMPGDVLELKIKEGDKVTKKQPLFVLSAMKMEMVIDSPIAGTVKAIHAPQGTKCSAGDLVVEVE 1174

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Query:  114 NYKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            NY ++ ++  ++  KV+VANRGEIAIRVFRA  E+   SVAIY+EQD   MHRLKADE+YL+GKGL PVAAYL I +II+ +  H++DAIHPGYGFLSERSDFAAAC  AGI FIGP  DV+ +MGDKV ARQAA++A V VVPG+PGPI T +EA+EF K+YG PIILKAAYGGGGRG+R V +LE + E F R+ SEA AAFG+G +F+EKF+ERPRHIEVQ+LGD  GN VHL+ERDCSVQRRHQK+VEIAPAP L   +R+K+L+DA++LA+ VGY+NAGTVEFL DQ    +YFIEVNARLQVEHTVTE++TGVDLV++QI IAEGKSL +L L+QE I++ G AIQCR+TTEDPA+ FQPDSGR+EVFRSGEGMGIRLDSASAFAG++ISP+YDSL++KVIA A N   A AKM+R+L++FR+RGVKTNIPFL NVL    FL+ SVDTYFIDEHP LFQFK SQNRAQKLL YLG + VNGP T LATDLKP++++P IP  P   + PTG RD+LV+ GP  FA+ VR  PGC+I DTTFRDAHQSLLATRVRTYDMA ISPFVAQ+F  LFSLENWGGATFDVSMRFL ECPWERL+TLRKLIPNIPFQ LLRGANA+GY+NYPDN++YKFC+LAV++GMD+FRVFD LNYLPN++VGM+AV KAGGVVEA+  Y+GD+TD ++ KY+L YYL LAD LVK  AHIL IKDMAGVLKP AA++LIG LR K+PDIPIH+H+HDT+GAGVA ML  A++G D+VD A+DSMSG+TSQPSMGA+VA LQ T  DTGL+L+ I  YS+YWE  R+LY PFEC TTM+SGNADVY ++IPGGQYTNLQFQ+FSLGL  QF+EVK+ Y  AN +LGD+IKVTPSSKIVGDLAQFMVQN +  +TLV++AD+LS PKSV++F QG+VG+P  GFPE LR+KV++    + GRPG++ K  D +A K EL +       ++D+MSY+++P VF EF+ FR+++GPV KL TR+FL G  IAEE+ V++E GKTL I+ LA   +   G REVFF+LNGQ+RS+ +VDKEASK I  RP+A   VRG +G+PMPG+VLE+K+KEGD V K Q L ++SAMKMEM ++SP+ G VK +H     K    DL++E+E
Sbjct:   21 NY-ANGVIKPREFNKVMVANRGEIAIRVFRALTELNKTSVAIYAEQDKNSMHRLKADEAYLVGKGLPPVAAYLTIDQIIETALKHNIDAIHPGYGFLSERSDFAAACQNAGIVFIGPSPDVMARMGDKVAARQAAIEAGVQVVPGTPGPITTADEAVEFAKQYGTPIILKAAYGGGGRGIRRVDKLEEVEEAFRRSYSEAQAAFGDGSLFVEKFVERPRHIEVQLLGDHHGNIVHLYERDCSVQRRHQKVVEIAPAPALPEGVREKILADALRLARHVGYQNAGTVEFLVDQ-KGNYYFIEVNARLQVEHTVTEEITGVDLVQAQIRIAEGKSLDDLKLSQETIQTTGSAIQCRVTTEDPAKGFQPDSGRIEVFRSGEGMGIRLDSASAFAGSVISPHYDSLMVKVIASARNHPNAAAKMIRALKKFRIRGVKTNIPFLLNVLRQPSFLDASVDTYFIDEHPELFQFKPSQNRAQKLLNYLGEVKVNGPTTPLATDLKPAVVSPPIPYIPAGAKPPTGLRDVLVQRGPTEFAKEVRSRPGCMITDTTFRDAHQSLLATRVRTYDMAAISPFVAQSFNGLFSLENWGGATFDVSMRFLHECPWERLQTLRKLIPNIPFQCLLRGANAMGYSNYPDNVIYKFCELAVKNGMDVFRVFDSLNYLPNLLVGMEAVGKAGGVVEAAIAYTGDVTDKSRDKYDLKYYLNLADQLVKAQAHILSIKDMAGVLKPEAAKLLIGALRDKFPDIPIHVHTHDTSGAGVAAMLECAKAGADVVDAAVDSMSGMTSQPSMGAIVASLQGTKHDTGLSLDDISKYSAYWESTRQLYAPFECATTMKSGNADVYKHEIPGGQYTNLQFQAFSLGLGPQFDEVKRMYREANLVLGDIIKVTPSSKIVGDLAQFMVQNNLTRETLVDRADDLSFPKSVVDFMQGNVGQPPYGFPEPLRTKVLRGKPKVDGRPGENAKPVDLDAVKVELEEKHGRTLSEEDVMSYSMFPTVFDEFETFRQQYGPVDKLPTRLFLTGLEIAEEVDVEIESGKTLAIQLLAEGKLNKRGEREVFFDLNGQMRSIFVVDKEASKEIVTRPRALPGVRGHIGAPMPGDVLELKIKEGDKVTKKQPLFVLSAMKMEMVIDSPIAGTVKAIHAPQGTKCSAGDLVVEVE 1174

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BLAST of Pyruvate carboxylase vs. Ensembl Celegans
Match: pyc-1 (Pyruvate carboxylase 1 [Source:UniProtKB/Swiss-Prot;Acc:O17732])

HSP 1 Score: 847.04 bits (2187), Expect = 0.000e+0
Identity = 403/615 (65.53%), Postives = 499/615 (81.14%), Query Frame = 3

Query: 1737 LIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            +I DTTFRDAHQSLLATRVRTYDMA ISPFVAQ+F  LFSLENWGGATFDVSMRFL ECPWERL+TLRKLIPNIPFQ LLRGANA+GY+NYPDN++YKFC+LAV++GMD+FRVFD LNYLPN++VGM+AV KAGGVVEA+  Y+GD+TD ++ KY+L YYL LAD LVK  AHIL IKDMAGVLKP AA++LIG LR K+PDIPIH+H+HDT+GAGVA ML  A++G D+VD A+DSMSG+TSQPSMGA+VA LQ T  DTGL+L+ I  YS+YWE  R+LY PFEC TTM+SGNADVY ++IPGGQYTNLQFQ+FSLGL  QF+EVK+ Y  AN +LGD+IKVTPSSKIVGDLAQFMVQN +  +TLV++AD+LS PKSV++F QG+VG+P  GFPE LR+KV++    + GRPG++ K  D +A K EL +       ++D+MSY+++P VF EF+ FR+++GPV KL TR+FL G  IAEE+ V++E GKTL I+ LA   +   G REVFF+LNGQ+RS+ +VDKEASK I  RP+A   VRG +G+PMPG+VLE+K+KEGD V K Q L ++SAMKMEM ++SP+ G VK +H     K    DL++E+E
Sbjct:    1 MITDTTFRDAHQSLLATRVRTYDMAAISPFVAQSFNGLFSLENWGGATFDVSMRFLHECPWERLQTLRKLIPNIPFQCLLRGANAMGYSNYPDNVIYKFCELAVKNGMDVFRVFDSLNYLPNLLVGMEAVGKAGGVVEAAIAYTGDVTDKSRDKYDLKYYLNLADQLVKAQAHILSIKDMAGVLKPEAAKLLIGALRDKFPDIPIHVHTHDTSGAGVAAMLECAKAGADVVDAAVDSMSGMTSQPSMGAIVASLQGTKHDTGLSLDDISKYSAYWESTRQLYAPFECATTMKSGNADVYKHEIPGGQYTNLQFQAFSLGLGPQFDEVKRMYREANLVLGDIIKVTPSSKIVGDLAQFMVQNNLTRETLVDRADDLSFPKSVVDFMQGNVGQPPYGFPEPLRTKVLRGKPKVDGRPGENAKPVDLDAVKVELEEKHGRTLSEEDVMSYSMFPTVFDEFETFRQQYGPVDKLPTRLFLTGLEIAEEVDVEIESGKTLAIQLLAEGKLNKRGEREVFFDLNGQMRSIFVVDKEASKEIVTRPRALPGVRGHIGAPMPGDVLELKIKEGDKVTKKQPLFVLSAMKMEMVIDSPIAGTVKAIHAPQGTKCSAGDLVVEVE 615

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BLAST of Pyruvate carboxylase vs. Ensembl Celegans
Match: mccc-1 (MethylCrotonoyl-Coenzyme A Carboxylase (Alpha) [Source:UniProtKB/TrEMBL;Acc:O45430])

HSP 1 Score: 362.073 bits (928), Expect = 1.537e-110
Identity = 208/454 (45.81%), Postives = 282/454 (62.11%), Query Frame = 3

Query:  144 KKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAA--YLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARD-FQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEH 1496
            + I++VLVANRGEIAIRV     +MGI +VA++S+ D   +   KAD++Y IG    P+AA  YLN+ +II  +      AIHPGYGFLSE + FA  C +AG+ FIGPPA  +R MG K  ++Q   DA V VV G  G  Q+     +   + G P++LKA YGGGG+GMR+        E    A++EA  +FGN EM +EKF+E+PRH+EVQ+ GD  GN VHL+ERDCSVQRRHQKI+E APAPN+    R K+   AV+ A  VGY  AGTVEF+ D    + YF+E+N RLQVEH V+E +TG DLV  Q+ +A+G+ LP   L Q EI   G+A +CR+  ED  +  F P +GRL      E    R+D+    +G  +S +YD ++ KV+    +  +A AK+  +L   R+ G+ TNI F+  VL +  F  G+V T FI +H
Sbjct:   17 RPIQRVLVANRGEIAIRVQNTARKMGIETVAVFSDADRNSLFVKKADKAYHIGP---PLAAESYLNMDKIINSALRSGAQAIHPGYGFLSENAGFAEKCAQAGLVFIGPPAQAIRDMGAKNVSKQIMEDAKVPVVKGFHGEDQSDANLKKKSAEIGYPVMLKAVYGGGGKGMRIAWNEAEFEEKLASARNEAKKSFGNDEMLVEKFVEKPRHVEVQVFGDHHGNYVHLWERDCSVQRRHQKIIEEAPAPNMEHDTRVKLGESAVRAAAAVGYVGAGTVEFIMDP-RGEFYFMEMNTRLQVEHPVSEAITGTDLVEWQLRVAQGEKLP---LKQSEIPLNGHAFECRVYAEDTRKGAFMPTAGRLNYVDFPEDA--RIDTG-VVSGDEVSIHYDPMIAKVVVWGQDRAVAAAKLESALARTRISGLPTNIDFVRRVLAHPEFAAGNVYTDFIPDH 460

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Query:  144 KKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAA--YLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARD-FQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEH 1496
            + I++VLVANRGEIAIRV     +MGI +VA++S+ D   +   KAD++Y IG    P+AA  YLN+ +II  +      AIHPGYGFLSE + FA  C +AG+ FIGPPA  +R MG K  ++Q   DA V VV G  G  Q+     +   + G P++LKA YGGGG+GMR+        E    A++EA  +FGN EM +EKF+E+PRH+EVQ+ GD  GN VHL+ERDCSVQRRHQKI+E APAPN+    R K+   AV+ A  VGY  AGTVEF+ D    + YF+E+N RLQVEH V+E +TG DLV  Q+ +A+G+ LP   L Q EI   G+A +CR+  ED  +  F P +GRL      E    R+D+    +G  +S +YD ++ KV+    +  +A AK+  +L   R+ G+ TNI F+  VL +  F  G+V T FI +H
Sbjct:   17 RPIQRVLVANRGEIAIRVQNTARKMGIETVAVFSDADRNSLFVKKADKAYHIGP---PLAAESYLNMDKIINSALRSGAQAIHPGYGFLSENAGFAEKCAQAGLVFIGPPAQAIRDMGAKNVSKQIMEDAKVPVVKGFHGEDQSDANLKKKSAEIGYPVMLKAVYGGGGKGMRIAWNEAEFEEKLASARNEAKKSFGNDEMLVEKFVEKPRHVEVQVFGDHHGNYVHLWERDCSVQRRHQKIIEEAPAPNMEHDTRVKLGESAVRAAAAVGYVGAGTVEFIMDP-RGEFYFMEMNTRLQVEHPVSEAITGTDLVEWQLRVAQGEKLP---LKQSEIPLNGHAFECRVYAEDTRKGAFMPTAGRLNYVDFPEDA--RIDTG-VVSGDEVSIHYDPMIAKVVVWGQDRAVAAAKLESALARTRISGLPTNIDFVRRVLAHPEFAAGNVYTDFIPDH 460

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BLAST of Pyruvate carboxylase vs. Ensembl Fly
Match: PCB (gene:FBgn0027580 transcript:FBtr0088455)

HSP 1 Score: 1613.97 bits (4178), Expect = 0.000e+0
Identity = 793/1175 (67.49%), Postives = 965/1175 (82.13%), Query Frame = 3

Query:   63 KCKPNFHSKFLFHNSGINYKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHD-FDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALS-DIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            K +P      +F N    Y S   +  K IR VLVANRGEIAIRVFRAC E+GI+SVA+YSEQD M MHR KADESY++GKGL PV AYLNI E+I++ K +DVDA+HPGYGFLSERSDFA A  +AG++FIGP  +VV+KMGDKV AR AA++A V +VPG+ GP+ T EEA+EF KK+GLP+I KAAYGGGGRGMRVV+++E + E+F RA SEA AAFGNG MFIEKFIERPRHIEVQ+LGDK GN VHL+ERDCSVQRRHQK+VEIAPAP L + IRDKM   AV+LA+ VGYENAGTVEFL D+ +   YFIEVNARLQVEHTVTE++TG+DLV+SQI +AEG +LPELG TQ++I   GYAIQCR+TTEDPA DFQP++GRLEVFRSGEGMGIRLDSASA+AGAIISPYYDSLL+KVI+HA++ + + +KM R+LREFR+RGVKTNIPFL NVLEN++FL+G +DTYFIDEHP LF+FK S NRAQKLL Y+G ++VNGP T LAT LKP+L++P +PE P+  E P G R++LV  GP+AFA+ VR     L+MDTTFRDAHQSLLATRVR++D+ +ISP+V   F NL+SLENWGGATFDV++RFL ECPWERLE +RK IPNIPFQMLLRGANAVGYT+YPDN+VYKFC+LAVQ+GMDIFRVFD LNYLPN+I+GM+A  KAGGVVEA+  Y+GD++DP +TKY+L YY  LAD+LVK G H+L IKDMAG+LKP +AR+LI  +R K+PDIPIH+H+HDT+GAGVA+MLA A +G D+VD A+DSMSG+TSQPSMGAVVA LQ TPLDT L+L  +  YS+YWEQ R LY PFECTTTMRSGNADVY N+IPGGQYTNLQFQ+FSLGL D FE+VK+ Y  AN LLGD+IKVTPSSK+VGDLAQFMVQN + A  ++E+A+ELS PKSV+E+ QG +G P+GGFPE LRS+V+K+   I GRPG +LK  DF+  K EL +  +H    ++D+MS ALYP V  +F  FRE++GPV KL TRIFL GP++ EE  V LE+GKTL +K LA+S D++P+G+REVFFELNGQLR+V I+DKEA K I V PKA KS +  VG+PMPG V++++VK GD V+KGQ L ++SAMKMEM V SP+ G VK + +A   K+EGEDL++ IE
Sbjct:   15 KTQPRVRLNAIFKNG---YSSK--VEYKPIRSVLVANRGEIAIRVFRACTELGIKSVAVYSEQDKMHMHRQKADESYIVGKGLPPVEAYLNIPELIRVCKENDVDAVHPGYGFLSERSDFAQAVIDAGLRFIGPSPEVVQKMGDKVAARVAAIEAGVPIVPGTDGPVTTKEEALEFCKKHGLPVIFKAAYGGGGRGMRVVRKMEDVEESFQRASSEAKAAFGNGAMFIEKFIERPRHIEVQLLGDKAGNVVHLYERDCSVQRRHQKVVEIAPAPRLPIEIRDKMTEAAVRLARHVGYENAGTVEFLCDE-SGNFYFIEVNARLQVEHTVTEEITGIDLVQSQIRVAEGMTLPELGYTQDKIVPRGYAIQCRVTTEDPANDFQPNTGRLEVFRSGEGMGIRLDSASAYAGAIISPYYDSLLVKVISHASDLQSSASKMNRALREFRIRGVKTNIPFLLNVLENQKFLHGVLDTYFIDEHPQLFKFKPSLNRAQKLLNYMGEVLVNGPQTPLATTLKPALVSPHVPEVPLVTEPPKGLREVLVCEGPEAFAKEVRNRKELLLMDTTFRDAHQSLLATRVRSHDLLKISPYVTHKFNNLYSLENWGGATFDVALRFLHECPWERLEEMRKRIPNIPFQMLLRGANAVGYTSYPDNVVYKFCELAVQTGMDIFRVFDSLNYLPNLILGMEAAGKAGGVVEAAISYTGDVSDPKRTKYDLKYYTNLADELVKAGTHVLCIKDMAGLLKPESARLLITAIRDKHPDIPIHIHTHDTSGAGVASMLACANAGADVVDVAVDSMSGMTSQPSMGAVVASLQGTPLDTNLDLRTVSEYSAYWEQTRTLYAPFECTTTMRSGNADVYLNEIPGGQYTNLQFQAFSLGLGDFFEDVKKAYREANLLLGDIIKVTPSSKVVGDLAQFMVQNDLTADQVLERAEELSFPKSVVEYLQGSIGIPHGGFPEPLRSRVLKDMPRIEGRPGAELKDLDFDKLKKELQE--SHTCVTNRDVMSAALYPQVTNDFLNFREKYGPVDKLDTRIFLTGPKVGEEFDVPLERGKTLSVKALAVSADLKPNGIREVFFELNGQLRAVHILDKEAVKEIHVHPKANKSNKSEVGAPMPGTVIDIRVKVGDKVEKGQPLVVLSAMKMEMVVQSPLAGVVKKLEIANGTKLEGEDLIMIIE 1181

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BLAST of Pyruvate carboxylase vs. Ensembl Fly
Match: PCB (gene:FBgn0027580 transcript:FBtr0088457)

HSP 1 Score: 1613.97 bits (4178), Expect = 0.000e+0
Identity = 793/1175 (67.49%), Postives = 965/1175 (82.13%), Query Frame = 3

Query:   63 KCKPNFHSKFLFHNSGINYKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHD-FDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALS-DIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            K +P      +F N    Y S   +  K IR VLVANRGEIAIRVFRAC E+GI+SVA+YSEQD M MHR KADESY++GKGL PV AYLNI E+I++ K +DVDA+HPGYGFLSERSDFA A  +AG++FIGP  +VV+KMGDKV AR AA++A V +VPG+ GP+ T EEA+EF KK+GLP+I KAAYGGGGRGMRVV+++E + E+F RA SEA AAFGNG MFIEKFIERPRHIEVQ+LGDK GN VHL+ERDCSVQRRHQK+VEIAPAP L + IRDKM   AV+LA+ VGYENAGTVEFL D+ +   YFIEVNARLQVEHTVTE++TG+DLV+SQI +AEG +LPELG TQ++I   GYAIQCR+TTEDPA DFQP++GRLEVFRSGEGMGIRLDSASA+AGAIISPYYDSLL+KVI+HA++ + + +KM R+LREFR+RGVKTNIPFL NVLEN++FL+G +DTYFIDEHP LF+FK S NRAQKLL Y+G ++VNGP T LAT LKP+L++P +PE P+  E P G R++LV  GP+AFA+ VR     L+MDTTFRDAHQSLLATRVR++D+ +ISP+V   F NL+SLENWGGATFDV++RFL ECPWERLE +RK IPNIPFQMLLRGANAVGYT+YPDN+VYKFC+LAVQ+GMDIFRVFD LNYLPN+I+GM+A  KAGGVVEA+  Y+GD++DP +TKY+L YY  LAD+LVK G H+L IKDMAG+LKP +AR+LI  +R K+PDIPIH+H+HDT+GAGVA+MLA A +G D+VD A+DSMSG+TSQPSMGAVVA LQ TPLDT L+L  +  YS+YWEQ R LY PFECTTTMRSGNADVY N+IPGGQYTNLQFQ+FSLGL D FE+VK+ Y  AN LLGD+IKVTPSSK+VGDLAQFMVQN + A  ++E+A+ELS PKSV+E+ QG +G P+GGFPE LRS+V+K+   I GRPG +LK  DF+  K EL +  +H    ++D+MS ALYP V  +F  FRE++GPV KL TRIFL GP++ EE  V LE+GKTL +K LA+S D++P+G+REVFFELNGQLR+V I+DKEA K I V PKA KS +  VG+PMPG V++++VK GD V+KGQ L ++SAMKMEM V SP+ G VK + +A   K+EGEDL++ IE
Sbjct:   15 KTQPRVRLNAIFKNG---YSSK--VEYKPIRSVLVANRGEIAIRVFRACTELGIKSVAVYSEQDKMHMHRQKADESYIVGKGLPPVEAYLNIPELIRVCKENDVDAVHPGYGFLSERSDFAQAVIDAGLRFIGPSPEVVQKMGDKVAARVAAIEAGVPIVPGTDGPVTTKEEALEFCKKHGLPVIFKAAYGGGGRGMRVVRKMEDVEESFQRASSEAKAAFGNGAMFIEKFIERPRHIEVQLLGDKAGNVVHLYERDCSVQRRHQKVVEIAPAPRLPIEIRDKMTEAAVRLARHVGYENAGTVEFLCDE-SGNFYFIEVNARLQVEHTVTEEITGIDLVQSQIRVAEGMTLPELGYTQDKIVPRGYAIQCRVTTEDPANDFQPNTGRLEVFRSGEGMGIRLDSASAYAGAIISPYYDSLLVKVISHASDLQSSASKMNRALREFRIRGVKTNIPFLLNVLENQKFLHGVLDTYFIDEHPQLFKFKPSLNRAQKLLNYMGEVLVNGPQTPLATTLKPALVSPHVPEVPLVTEPPKGLREVLVCEGPEAFAKEVRNRKELLLMDTTFRDAHQSLLATRVRSHDLLKISPYVTHKFNNLYSLENWGGATFDVALRFLHECPWERLEEMRKRIPNIPFQMLLRGANAVGYTSYPDNVVYKFCELAVQTGMDIFRVFDSLNYLPNLILGMEAAGKAGGVVEAAISYTGDVSDPKRTKYDLKYYTNLADELVKAGTHVLCIKDMAGLLKPESARLLITAIRDKHPDIPIHIHTHDTSGAGVASMLACANAGADVVDVAVDSMSGMTSQPSMGAVVASLQGTPLDTNLDLRTVSEYSAYWEQTRTLYAPFECTTTMRSGNADVYLNEIPGGQYTNLQFQAFSLGLGDFFEDVKKAYREANLLLGDIIKVTPSSKVVGDLAQFMVQNDLTADQVLERAEELSFPKSVVEYLQGSIGIPHGGFPEPLRSRVLKDMPRIEGRPGAELKDLDFDKLKKELQE--SHTCVTNRDVMSAALYPQVTNDFLNFREKYGPVDKLDTRIFLTGPKVGEEFDVPLERGKTLSVKALAVSADLKPNGIREVFFELNGQLRAVHILDKEAVKEIHVHPKANKSNKSEVGAPMPGTVIDIRVKVGDKVEKGQPLVVLSAMKMEMVVQSPLAGVVKKLEIANGTKLEGEDLIMIIE 1181

[Close]

BLAST of Pyruvate carboxylase vs. Ensembl Fly
Match: PCB (gene:FBgn0027580 transcript:FBtr0088456)

HSP 1 Score: 1613.97 bits (4178), Expect = 0.000e+0
Identity = 793/1175 (67.49%), Postives = 965/1175 (82.13%), Query Frame = 3

Query:   63 KCKPNFHSKFLFHNSGINYKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHD-FDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALS-DIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            K +P      +F N    Y S   +  K IR VLVANRGEIAIRVFRAC E+GI+SVA+YSEQD M MHR KADESY++GKGL PV AYLNI E+I++ K +DVDA+HPGYGFLSERSDFA A  +AG++FIGP  +VV+KMGDKV AR AA++A V +VPG+ GP+ T EEA+EF KK+GLP+I KAAYGGGGRGMRVV+++E + E+F RA SEA AAFGNG MFIEKFIERPRHIEVQ+LGDK GN VHL+ERDCSVQRRHQK+VEIAPAP L + IRDKM   AV+LA+ VGYENAGTVEFL D+ +   YFIEVNARLQVEHTVTE++TG+DLV+SQI +AEG +LPELG TQ++I   GYAIQCR+TTEDPA DFQP++GRLEVFRSGEGMGIRLDSASA+AGAIISPYYDSLL+KVI+HA++ + + +KM R+LREFR+RGVKTNIPFL NVLEN++FL+G +DTYFIDEHP LF+FK S NRAQKLL Y+G ++VNGP T LAT LKP+L++P +PE P+  E P G R++LV  GP+AFA+ VR     L+MDTTFRDAHQSLLATRVR++D+ +ISP+V   F NL+SLENWGGATFDV++RFL ECPWERLE +RK IPNIPFQMLLRGANAVGYT+YPDN+VYKFC+LAVQ+GMDIFRVFD LNYLPN+I+GM+A  KAGGVVEA+  Y+GD++DP +TKY+L YY  LAD+LVK G H+L IKDMAG+LKP +AR+LI  +R K+PDIPIH+H+HDT+GAGVA+MLA A +G D+VD A+DSMSG+TSQPSMGAVVA LQ TPLDT L+L  +  YS+YWEQ R LY PFECTTTMRSGNADVY N+IPGGQYTNLQFQ+FSLGL D FE+VK+ Y  AN LLGD+IKVTPSSK+VGDLAQFMVQN + A  ++E+A+ELS PKSV+E+ QG +G P+GGFPE LRS+V+K+   I GRPG +LK  DF+  K EL +  +H    ++D+MS ALYP V  +F  FRE++GPV KL TRIFL GP++ EE  V LE+GKTL +K LA+S D++P+G+REVFFELNGQLR+V I+DKEA K I V PKA KS +  VG+PMPG V++++VK GD V+KGQ L ++SAMKMEM V SP+ G VK + +A   K+EGEDL++ IE
Sbjct:   15 KTQPRVRLNAIFKNG---YSSK--VEYKPIRSVLVANRGEIAIRVFRACTELGIKSVAVYSEQDKMHMHRQKADESYIVGKGLPPVEAYLNIPELIRVCKENDVDAVHPGYGFLSERSDFAQAVIDAGLRFIGPSPEVVQKMGDKVAARVAAIEAGVPIVPGTDGPVTTKEEALEFCKKHGLPVIFKAAYGGGGRGMRVVRKMEDVEESFQRASSEAKAAFGNGAMFIEKFIERPRHIEVQLLGDKAGNVVHLYERDCSVQRRHQKVVEIAPAPRLPIEIRDKMTEAAVRLARHVGYENAGTVEFLCDE-SGNFYFIEVNARLQVEHTVTEEITGIDLVQSQIRVAEGMTLPELGYTQDKIVPRGYAIQCRVTTEDPANDFQPNTGRLEVFRSGEGMGIRLDSASAYAGAIISPYYDSLLVKVISHASDLQSSASKMNRALREFRIRGVKTNIPFLLNVLENQKFLHGVLDTYFIDEHPQLFKFKPSLNRAQKLLNYMGEVLVNGPQTPLATTLKPALVSPHVPEVPLVTEPPKGLREVLVCEGPEAFAKEVRNRKELLLMDTTFRDAHQSLLATRVRSHDLLKISPYVTHKFNNLYSLENWGGATFDVALRFLHECPWERLEEMRKRIPNIPFQMLLRGANAVGYTSYPDNVVYKFCELAVQTGMDIFRVFDSLNYLPNLILGMEAAGKAGGVVEAAISYTGDVSDPKRTKYDLKYYTNLADELVKAGTHVLCIKDMAGLLKPESARLLITAIRDKHPDIPIHIHTHDTSGAGVASMLACANAGADVVDVAVDSMSGMTSQPSMGAVVASLQGTPLDTNLDLRTVSEYSAYWEQTRTLYAPFECTTTMRSGNADVYLNEIPGGQYTNLQFQAFSLGLGDFFEDVKKAYREANLLLGDIIKVTPSSKVVGDLAQFMVQNDLTADQVLERAEELSFPKSVVEYLQGSIGIPHGGFPEPLRSRVLKDMPRIEGRPGAELKDLDFDKLKKELQE--SHTCVTNRDVMSAALYPQVTNDFLNFREKYGPVDKLDTRIFLTGPKVGEEFDVPLERGKTLSVKALAVSADLKPNGIREVFFELNGQLRAVHILDKEAVKEIHVHPKANKSNKSEVGAPMPGTVIDIRVKVGDKVEKGQPLVVLSAMKMEMVVQSPLAGVVKKLEIANGTKLEGEDLIMIIE 1181

[Close]

BLAST of Pyruvate carboxylase vs. Ensembl Fly
Match: PCB (gene:FBgn0027580 transcript:FBtr0088459)

HSP 1 Score: 1613.97 bits (4178), Expect = 0.000e+0
Identity = 793/1175 (67.49%), Postives = 965/1175 (82.13%), Query Frame = 3

Query:   63 KCKPNFHSKFLFHNSGINYKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHD-FDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALS-DIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            K +P      +F N    Y S   +  K IR VLVANRGEIAIRVFRAC E+GI+SVA+YSEQD M MHR KADESY++GKGL PV AYLNI E+I++ K +DVDA+HPGYGFLSERSDFA A  +AG++FIGP  +VV+KMGDKV AR AA++A V +VPG+ GP+ T EEA+EF KK+GLP+I KAAYGGGGRGMRVV+++E + E+F RA SEA AAFGNG MFIEKFIERPRHIEVQ+LGDK GN VHL+ERDCSVQRRHQK+VEIAPAP L + IRDKM   AV+LA+ VGYENAGTVEFL D+ +   YFIEVNARLQVEHTVTE++TG+DLV+SQI +AEG +LPELG TQ++I   GYAIQCR+TTEDPA DFQP++GRLEVFRSGEGMGIRLDSASA+AGAIISPYYDSLL+KVI+HA++ + + +KM R+LREFR+RGVKTNIPFL NVLEN++FL+G +DTYFIDEHP LF+FK S NRAQKLL Y+G ++VNGP T LAT LKP+L++P +PE P+  E P G R++LV  GP+AFA+ VR     L+MDTTFRDAHQSLLATRVR++D+ +ISP+V   F NL+SLENWGGATFDV++RFL ECPWERLE +RK IPNIPFQMLLRGANAVGYT+YPDN+VYKFC+LAVQ+GMDIFRVFD LNYLPN+I+GM+A  KAGGVVEA+  Y+GD++DP +TKY+L YY  LAD+LVK G H+L IKDMAG+LKP +AR+LI  +R K+PDIPIH+H+HDT+GAGVA+MLA A +G D+VD A+DSMSG+TSQPSMGAVVA LQ TPLDT L+L  +  YS+YWEQ R LY PFECTTTMRSGNADVY N+IPGGQYTNLQFQ+FSLGL D FE+VK+ Y  AN LLGD+IKVTPSSK+VGDLAQFMVQN + A  ++E+A+ELS PKSV+E+ QG +G P+GGFPE LRS+V+K+   I GRPG +LK  DF+  K EL +  +H    ++D+MS ALYP V  +F  FRE++GPV KL TRIFL GP++ EE  V LE+GKTL +K LA+S D++P+G+REVFFELNGQLR+V I+DKEA K I V PKA KS +  VG+PMPG V++++VK GD V+KGQ L ++SAMKMEM V SP+ G VK + +A   K+EGEDL++ IE
Sbjct:   15 KTQPRVRLNAIFKNG---YSSK--VEYKPIRSVLVANRGEIAIRVFRACTELGIKSVAVYSEQDKMHMHRQKADESYIVGKGLPPVEAYLNIPELIRVCKENDVDAVHPGYGFLSERSDFAQAVIDAGLRFIGPSPEVVQKMGDKVAARVAAIEAGVPIVPGTDGPVTTKEEALEFCKKHGLPVIFKAAYGGGGRGMRVVRKMEDVEESFQRASSEAKAAFGNGAMFIEKFIERPRHIEVQLLGDKAGNVVHLYERDCSVQRRHQKVVEIAPAPRLPIEIRDKMTEAAVRLARHVGYENAGTVEFLCDE-SGNFYFIEVNARLQVEHTVTEEITGIDLVQSQIRVAEGMTLPELGYTQDKIVPRGYAIQCRVTTEDPANDFQPNTGRLEVFRSGEGMGIRLDSASAYAGAIISPYYDSLLVKVISHASDLQSSASKMNRALREFRIRGVKTNIPFLLNVLENQKFLHGVLDTYFIDEHPQLFKFKPSLNRAQKLLNYMGEVLVNGPQTPLATTLKPALVSPHVPEVPLVTEPPKGLREVLVCEGPEAFAKEVRNRKELLLMDTTFRDAHQSLLATRVRSHDLLKISPYVTHKFNNLYSLENWGGATFDVALRFLHECPWERLEEMRKRIPNIPFQMLLRGANAVGYTSYPDNVVYKFCELAVQTGMDIFRVFDSLNYLPNLILGMEAAGKAGGVVEAAISYTGDVSDPKRTKYDLKYYTNLADELVKAGTHVLCIKDMAGLLKPESARLLITAIRDKHPDIPIHIHTHDTSGAGVASMLACANAGADVVDVAVDSMSGMTSQPSMGAVVASLQGTPLDTNLDLRTVSEYSAYWEQTRTLYAPFECTTTMRSGNADVYLNEIPGGQYTNLQFQAFSLGLGDFFEDVKKAYREANLLLGDIIKVTPSSKVVGDLAQFMVQNDLTADQVLERAEELSFPKSVVEYLQGSIGIPHGGFPEPLRSRVLKDMPRIEGRPGAELKDLDFDKLKKELQE--SHTCVTNRDVMSAALYPQVTNDFLNFREKYGPVDKLDTRIFLTGPKVGEEFDVPLERGKTLSVKALAVSADLKPNGIREVFFELNGQLRAVHILDKEAVKEIHVHPKANKSNKSEVGAPMPGTVIDIRVKVGDKVEKGQPLVVLSAMKMEMVVQSPLAGVVKKLEIANGTKLEGEDLIMIIE 1181

[Close]

BLAST of Pyruvate carboxylase vs. Ensembl Fly
Match: PCB (gene:FBgn0027580 transcript:FBtr0088462)

HSP 1 Score: 1613.97 bits (4178), Expect = 0.000e+0
Identity = 793/1175 (67.49%), Postives = 965/1175 (82.13%), Query Frame = 3

Query:   63 KCKPNFHSKFLFHNSGINYKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHD-FDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALS-DIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            K +P      +F N    Y S   +  K IR VLVANRGEIAIRVFRAC E+GI+SVA+YSEQD M MHR KADESY++GKGL PV AYLNI E+I++ K +DVDA+HPGYGFLSERSDFA A  +AG++FIGP  +VV+KMGDKV AR AA++A V +VPG+ GP+ T EEA+EF KK+GLP+I KAAYGGGGRGMRVV+++E + E+F RA SEA AAFGNG MFIEKFIERPRHIEVQ+LGDK GN VHL+ERDCSVQRRHQK+VEIAPAP L + IRDKM   AV+LA+ VGYENAGTVEFL D+ +   YFIEVNARLQVEHTVTE++TG+DLV+SQI +AEG +LPELG TQ++I   GYAIQCR+TTEDPA DFQP++GRLEVFRSGEGMGIRLDSASA+AGAIISPYYDSLL+KVI+HA++ + + +KM R+LREFR+RGVKTNIPFL NVLEN++FL+G +DTYFIDEHP LF+FK S NRAQKLL Y+G ++VNGP T LAT LKP+L++P +PE P+  E P G R++LV  GP+AFA+ VR     L+MDTTFRDAHQSLLATRVR++D+ +ISP+V   F NL+SLENWGGATFDV++RFL ECPWERLE +RK IPNIPFQMLLRGANAVGYT+YPDN+VYKFC+LAVQ+GMDIFRVFD LNYLPN+I+GM+A  KAGGVVEA+  Y+GD++DP +TKY+L YY  LAD+LVK G H+L IKDMAG+LKP +AR+LI  +R K+PDIPIH+H+HDT+GAGVA+MLA A +G D+VD A+DSMSG+TSQPSMGAVVA LQ TPLDT L+L  +  YS+YWEQ R LY PFECTTTMRSGNADVY N+IPGGQYTNLQFQ+FSLGL D FE+VK+ Y  AN LLGD+IKVTPSSK+VGDLAQFMVQN + A  ++E+A+ELS PKSV+E+ QG +G P+GGFPE LRS+V+K+   I GRPG +LK  DF+  K EL +  +H    ++D+MS ALYP V  +F  FRE++GPV KL TRIFL GP++ EE  V LE+GKTL +K LA+S D++P+G+REVFFELNGQLR+V I+DKEA K I V PKA KS +  VG+PMPG V++++VK GD V+KGQ L ++SAMKMEM V SP+ G VK + +A   K+EGEDL++ IE
Sbjct:   15 KTQPRVRLNAIFKNG---YSSK--VEYKPIRSVLVANRGEIAIRVFRACTELGIKSVAVYSEQDKMHMHRQKADESYIVGKGLPPVEAYLNIPELIRVCKENDVDAVHPGYGFLSERSDFAQAVIDAGLRFIGPSPEVVQKMGDKVAARVAAIEAGVPIVPGTDGPVTTKEEALEFCKKHGLPVIFKAAYGGGGRGMRVVRKMEDVEESFQRASSEAKAAFGNGAMFIEKFIERPRHIEVQLLGDKAGNVVHLYERDCSVQRRHQKVVEIAPAPRLPIEIRDKMTEAAVRLARHVGYENAGTVEFLCDE-SGNFYFIEVNARLQVEHTVTEEITGIDLVQSQIRVAEGMTLPELGYTQDKIVPRGYAIQCRVTTEDPANDFQPNTGRLEVFRSGEGMGIRLDSASAYAGAIISPYYDSLLVKVISHASDLQSSASKMNRALREFRIRGVKTNIPFLLNVLENQKFLHGVLDTYFIDEHPQLFKFKPSLNRAQKLLNYMGEVLVNGPQTPLATTLKPALVSPHVPEVPLVTEPPKGLREVLVCEGPEAFAKEVRNRKELLLMDTTFRDAHQSLLATRVRSHDLLKISPYVTHKFNNLYSLENWGGATFDVALRFLHECPWERLEEMRKRIPNIPFQMLLRGANAVGYTSYPDNVVYKFCELAVQTGMDIFRVFDSLNYLPNLILGMEAAGKAGGVVEAAISYTGDVSDPKRTKYDLKYYTNLADELVKAGTHVLCIKDMAGLLKPESARLLITAIRDKHPDIPIHIHTHDTSGAGVASMLACANAGADVVDVAVDSMSGMTSQPSMGAVVASLQGTPLDTNLDLRTVSEYSAYWEQTRTLYAPFECTTTMRSGNADVYLNEIPGGQYTNLQFQAFSLGLGDFFEDVKKAYREANLLLGDIIKVTPSSKVVGDLAQFMVQNDLTADQVLERAEELSFPKSVVEYLQGSIGIPHGGFPEPLRSRVLKDMPRIEGRPGAELKDLDFDKLKKELQE--SHTCVTNRDVMSAALYPQVTNDFLNFREKYGPVDKLDTRIFLTGPKVGEEFDVPLERGKTLSVKALAVSADLKPNGIREVFFELNGQLRAVHILDKEAVKEIHVHPKANKSNKSEVGAPMPGTVIDIRVKVGDKVEKGQPLVVLSAMKMEMVVQSPLAGVVKKLEIANGTKLEGEDLIMIIE 1181

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BLAST of Pyruvate carboxylase vs. Ensembl Zebrafish
Match: pcxa (pyruvate carboxylase a [Source:ZFIN;Acc:ZDB-GENE-090908-3])

HSP 1 Score: 1562.74 bits (4045), Expect = 0.000e+0
Identity = 769/1154 (66.64%), Postives = 935/1154 (81.02%), Query Frame = 3

Query:  117 YKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEI 3578
            + + Q L  K I+KV+VANRGEIAIRVFRAC E+GIR+VA+YSEQDT QMHR KADE+YLIGKGL PVAAYL+I +IIK++K +DVDAIHPGYGFLSER+DFA AC +AG++FIGP  DVVRKMGDKV+AR  A+ A V VVPG+  PI   +EA EF   YG PII KAAYGGGGRGMRVV+E E L EN+ RA SEALAAFGNG +F+EKFIE+PRHIEVQILGDK+GN +HL+ERDCS+QRRHQK+VEIAPA  L   +RD++ +D+V LA+ VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +Q+ + EG+SLPELGL Q++IR  GYAIQCR+TTEDPAR FQPD+GRLEVFRSGEGMGIRLDSASAF GA+ISP+YDSLL+KVIA   +   A AKM R+L EFRVRGVKTNIPFL NVL N +FLNG+VDT FIDE+ +LF  K  QNRAQKLL YLG +MVNGP T +    KPS I+P IP  P+  E P G+RD+L++ GP  FA+AVR H G L+MDTTFRDAHQSLLATRVRT+D+  I+PFVA +F NLFS+ENWGGATFDV+MRFL ECPW+RL+ LR L+PN+PFQMLLRGANAVGYTNYPDN V+KFC++A ++GMDIFRVFD LNYLPN+++GM+A   AGGVVEA+  Y+GD++DPT+ KY+L YYLKLAD+LVK G HIL IKDMAG+LKP++ R+L+G LR ++P +PIH+H+HDTAGAGVA MLA AE+G DIVD A+DSM+G+TSQPSMGAVVAC + T L+TG++LEK++ YS YWE  R LY PF+CT TM+SGNADVY N+IPGGQYTNL FQ+ S+GL ++F+EVK+ Y  AN LLGD+IKVTPSSKIVGDLAQFMVQN +    + E+ADELS P SV+EF QGH+G P+GGFPE  R+KV+K+   + GRPG  L A DF+A + +L D    +   +D+MS A+YP VF+EF+ F   FGPV  L TR+FL GP+IAEE  V+LE+GKTLHIK LAL D+  +G REVFFELNGQLRSV + D  A K +   PKA K VRG +G+PMPG+V+EVKVK+G  V+KGQ LC++SAMKME  VNSP+ G V  ++V     +EG+DL++EI
Sbjct:   28 HTAPQTLEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAYLIGKGLPPVAAYLHIPDIIKVAKANDVDAIHPGYGFLSERADFAQACVDAGVRFIGPTPDVVRKMGDKVQARAIAISAGVPVVPGTDAPISCLQEAQEFSNSYGFPIIFKAAYGGGGRGMRVVREYEELEENYQRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDKYGNVIHLYERDCSIQRRHQKVVEIAPATQLDPHLRDRLTADSVNLARQVGYENAGTVEFLVDK-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQLRVCEGRSLPELGLKQDKIRINGYAIQCRVTTEDPARGFQPDTGRLEVFRSGEGMGIRLDSASAFQGAVISPHYDSLLVKVIASGKDLPAASAKMSRALAEFRVRGVKTNIPFLQNVLSNNQFLNGTVDTQFIDENSDLFNLKPVQNRAQKLLHYLGHVMVNGPTTPIPVKAKPSPIDPVIPPVPLG-EPPVGFRDVLLREGPDGFAKAVRAHQGLLLMDTTFRDAHQSLLATRVRTHDLKRIAPFVAHSFNNLFSVENWGGATFDVAMRFLCECPWKRLQELRALMPNVPFQMLLRGANAVGYTNYPDNAVFKFCEVAKENGMDIFRVFDSLNYLPNMLLGMEAAGTAGGVVEAAISYTGDVSDPTRQKYSLDYYLKLADELVKAGTHILCIKDMAGLLKPDSGRLLVGALRDRFPHVPIHVHTHDTAGAGVAAMLACAEAGADIVDVAVDSMAGMTSQPSMGAVVACTKGTKLNTGISLEKVFDYSEYWEVTRGLYAPFDCTATMKSGNADVYENEIPGGQYTNLHFQAHSMGLGNKFKEVKKSYTEANKLLGDLIKVTPSSKIVGDLAQFMVQNSLTRAEVEERADELSFPLSVVEFLQGHIGIPHGGFPEPFRTKVLKSLPRVEGRPGASLPAMDFQALEKQLKDAHGDEITPEDVMSAAMYPKVFQEFKDFTRTFGPVDCLDTRLFLDGPKIAEEFEVELERGKTLHIKALALGDLNKAGQREVFFELNGQLRSVLVKDTVAMKEMHFHPKALKDVRGQIGAPMPGKVVEVKVKQGQQVEKGQPLCVLSAMKMETVVNSPISGTVAKIYVTADSTLEGDDLILEI 1179

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Query:  117 YKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEI 3578
            + + Q L  K I+KV+VANRGEIAIRVFRAC E+GIR+VA+YSEQDT QMHR KADE+YLIGKGL PVAAYL+I +IIK++K +DVDAIHPGYGFLSER+DFA AC +AG++FIGP  DVVRKMGDKV+AR  A+ A V VVPG+  PI   +EA EF   YG PII KAAYGGGGRGMRVV+E E L EN+ RA SEALAAFGNG +F+EKFIE+PRHIEVQILGDK+GN +HL+ERDCS+QRRHQK+VEIAPA  L   +RD++ +D+V LA+ VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +Q+ + EG+SLPELGL Q++IR  GYAIQCR+TTEDPAR FQPD+GRLEVFRSGEGMGIRLDSASAF GA+ISP+YDSLL+KVIA   +   A AKM R+L EFRVRGVKTNIPFL NVL N +FLNG+VDT FIDE+ +LF  K  QNRAQKLL YLG +MVNGP T +    KPS I+P IP  P+  E P G+RD+L++ GP  FA+AVR H G L+MDTTFRDAHQSLLATRVRT+D+  I+PFVA +F NLFS+ENWGGATFDV+MRFL ECPW+RL+ LR L+PN+PFQMLLRGANAVGYTNYPDN V+KFC++A ++GMDIFRVFD LNYLPN+++GM+A   AGGVVEA+  Y+GD++DPT+ KY+L YYLKLAD+LVK G HIL IKDMAG+LKP++ R+L+G LR ++P +PIH+H+HDTAGAGVA MLA AE+G DIVD A+DSM+G+TSQPSMGAVVAC + T L+TG++LEK++ YS YWE  R LY PF+CT TM+SGNADVY N+IPGGQYTNL FQ+ S+GL ++F+EVK+ Y  AN LLGD+IKVTPSSKIVGDLAQFMVQN +    + E+ADELS P SV+EF QGH+G P+GGFPE  R+KV+K+   + GRPG  L A DF+A + +L D    +   +D+MS A+YP VF+EF+ F   FGPV  L TR+FL GP+IAEE  V+LE+GKTLHIK LAL D+  +G REVFFELNGQLRSV + D  A K +   PKA K VRG +G+PMPG+V+EVKVK+G  V+KGQ LC++SAMKME  VNSP+ G V  ++V     +EG+DL++EI
Sbjct:   28 HTAPQTLEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAYLIGKGLPPVAAYLHIPDIIKVAKANDVDAIHPGYGFLSERADFAQACVDAGVRFIGPTPDVVRKMGDKVQARAIAISAGVPVVPGTDAPISCLQEAQEFSNSYGFPIIFKAAYGGGGRGMRVVREYEELEENYQRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDKYGNVIHLYERDCSIQRRHQKVVEIAPATQLDPHLRDRLTADSVNLARQVGYENAGTVEFLVDK-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQLRVCEGRSLPELGLKQDKIRINGYAIQCRVTTEDPARGFQPDTGRLEVFRSGEGMGIRLDSASAFQGAVISPHYDSLLVKVIASGKDLPAASAKMSRALAEFRVRGVKTNIPFLQNVLSNNQFLNGTVDTQFIDENSDLFNLKPVQNRAQKLLHYLGHVMVNGPTTPIPVKAKPSPIDPVIPPVPLG-EPPVGFRDVLLREGPDGFAKAVRAHQGLLLMDTTFRDAHQSLLATRVRTHDLKRIAPFVAHSFNNLFSVENWGGATFDVAMRFLCECPWKRLQELRALMPNVPFQMLLRGANAVGYTNYPDNAVFKFCEVAKENGMDIFRVFDSLNYLPNMLLGMEAAGTAGGVVEAAISYTGDVSDPTRQKYSLDYYLKLADELVKAGTHILCIKDMAGLLKPDSGRLLVGALRDRFPHVPIHVHTHDTAGAGVAAMLACAEAGADIVDVAVDSMAGMTSQPSMGAVVACTKGTKLNTGISLEKVFDYSEYWEVTRGLYAPFDCTATMKSGNADVYENEIPGGQYTNLHFQAHSMGLGNKFKEVKKSYTEANKLLGDLIKVTPSSKIVGDLAQFMVQNSLTRAEVEERADELSFPLSVVEFLQGHIGIPHGGFPEPFRTKVLKSLPRVEGRPGASLPAMDFQALEKQLKDAHGDEITPEDVMSAAMYPKVFQEFKDFTRTFGPVDCLDTRLFLDGPKIAEEFEVELERGKTLHIKALALGDLNKAGQREVFFELNGQLRSVLVKDTVAMKEMHFHPKALKDVRGQIGAPMPGKVVEVKVKQGQQVEKGQPLCVLSAMKMETVVNSPISGTVAKIYVTADSTLEGDDLILEI 1179

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BLAST of Pyruvate carboxylase vs. Ensembl Zebrafish
Match: pcxb (pyruvate carboxylase b [Source:ZFIN;Acc:ZDB-GENE-000831-1])

HSP 1 Score: 1539.24 bits (3984), Expect = 0.000e+0
Identity = 763/1152 (66.23%), Postives = 927/1152 (80.47%), Query Frame = 3

Query:  123 SDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEI 3578
            S Q L    I+KV+VANRGEIAIRVFRAC E+GIR+VA+YSEQDT QMHR KADE+YLIG+GL PVAAYL+I +IIK++K ++VDAIHPGYGFLSER+DFA AC EAG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI   +EA EF K Y  PII KAAYGGGGRGMRVV+  E L EN+ RA SEALAAFGNG +F+EKFIE+PRHIEVQILGDK+GN +HL+ERDCS+QRRHQK+VEIAPA +L   +RD++  D+V LAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +Q+ + EG+SLPELGL Q++I+  G AIQCR+TTEDP+R FQPD+GR+EVFRSGEGMGIRLDSASAF GAIISP+YDSLL+KVIA   +   A  KM R+L EFRVRGVKTNIPFL NVL N +FL  +VDT FIDE+ NLF  K +QNRAQKLL YLG +MVNGP+T +    KPS ++P IP   +  E P G+R++L++ GP+ FA+A+R+H G L+MDTTFRDAHQSLLATRVRT+D+ +I+P+V+ NF NLFSLENWGGATFDV+MRFL ECPW+RL+ LR LIPN+PFQMLLRGANAVGYTNYPDN V+KFC++A ++GMDIFRVFD LNY+PN+++GM+A   AGGVVEA+  Y+GD++DP + KY+L YYLKLAD+LVK G HIL IKDMAG+LKP A+R+LI  LR ++PDIPIH+H+HDTAGAGVA MLA A++G DIVD A+DSM+G+TSQPSMGA+VAC + T LDTG++L+K++ YS YWE AR LY PF+CT TM+SGNADVY N+IPGGQYTNL FQ+ S+GL ++F+EVK+ Y  AN LLGD+IKVTPSSKIVGDLAQFMVQN +    + ++ADELS P SV+EF QGH+G P+GGFPE  RSKV+K+   I GRPG  L   DFEA +  L      +   +D+MS A+YP VF+EF+ F   FGPV  L TR+FL GP+IAEE  V+LE+GK LHIK LAL D+  SG REVFFELNGQLRSV + D  A K +   PKA K VRG VG+PMPG+V+EVKVK G  V+KGQ LC++SAMKME  VNSP+ G +  VHV     +EGEDL++EI
Sbjct:   30 SSQTLEYHPIKKVMVANRGEIAIRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAYLIGRGLSPVAAYLHIPDIIKVAKENNVDAIHPGYGFLSERADFAQACAEAGVRFIGPSPEVVRKMGDKVEARALAIKAGVPVVPGTDAPISCLQEAQEFAKTYDFPIIFKAAYGGGGRGMRVVRNYEELEENYQRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDKYGNVIHLYERDCSIQRRHQKVVEIAPAAHLDSHLRDRLTLDSVNLAKQVGYENAGTVEFLVDK-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQLRVCEGRSLPELGLEQDKIQINGCAIQCRVTTEDPSRGFQPDTGRIEVFRSGEGMGIRLDSASAFQGAIISPHYDSLLVKVIASGKDLPTAATKMHRALTEFRVRGVKTNIPFLQNVLSNSQFLYATVDTQFIDENQNLFNLKPTQNRAQKLLHYLGHVMVNGPMTPIPVKAKPSPVDPVIPSVSLG-EPPLGFREVLLREGPEGFARAIRQHQGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVSHNFSNLFSLENWGGATFDVAMRFLSECPWKRLQELRALIPNVPFQMLLRGANAVGYTNYPDNAVFKFCEVAKENGMDIFRVFDSLNYIPNMLLGMEAAGAAGGVVEAAISYTGDVSDPMRQKYSLDYYLKLADELVKAGTHILSIKDMAGLLKPQASRLLIEALRDRFPDIPIHVHTHDTAGAGVAAMLACAQAGADIVDVAVDSMAGMTSQPSMGAIVACTKGTKLDTGISLDKVFDYSEYWEVARGLYAPFDCTATMKSGNADVYENEIPGGQYTNLHFQAHSMGLGNKFKEVKKAYTEANKLLGDLIKVTPSSKIVGDLAQFMVQNSLSLAEVEKRADELSFPLSVVEFLQGHIGIPHGGFPEPFRSKVLKSLPRIEGRPGASLPPMDFEALESGLRAAHGDEITPEDVMSAAMYPKVFQEFKEFTSTFGPVDCLNTRLFLDGPKIAEEFQVELERGKILHIKALALGDLNKSGQREVFFELNGQLRSVLVKDTAAMKEMHFHPKALKDVRGQVGAPMPGKVVEVKVKAGQKVEKGQPLCVLSAMKMETVVNSPISGIISKVHVNADSSLEGEDLILEI 1179

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BLAST of Pyruvate carboxylase vs. Ensembl Zebrafish
Match: pcxb (pyruvate carboxylase b [Source:ZFIN;Acc:ZDB-GENE-000831-1])

HSP 1 Score: 603.594 bits (1555), Expect = 0.000e+0
Identity = 304/432 (70.37%), Postives = 359/432 (83.10%), Query Frame = 3

Query:  123 SDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTN 1418
            S Q L    I+KV+VANRGEIAIRVFRAC E+GIR+VA+YSEQDT QMHR KADE+YLIG+GL PVAAYL+I +IIK++K ++VDAIHPGYGFLSER+DFA AC EAG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI   +EA EF K Y  PII KAAYGGGGRGMRVV+  E L EN+ RA SEALAAFGNG +F+EKFIE+PRHIEVQILGDK+GN +HL+ERDCS+QRRHQK+VEIAPA +L   +RD++  D+V LAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +Q+ + EG+SLPELGL Q++I+  G AIQCR+TTEDP+R FQPD+GR+EVFRSGEGMGIRLDSASAF GAIISP+YDSLL+KVIA   +   A  KM R+L EFRVRGVK +
Sbjct:   30 SSQTLEYHPIKKVMVANRGEIAIRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAYLIGRGLSPVAAYLHIPDIIKVAKENNVDAIHPGYGFLSERADFAQACAEAGVRFIGPSPEVVRKMGDKVEARALAIKAGVPVVPGTDAPISCLQEAQEFAKTYDFPIIFKAAYGGGGRGMRVVRNYEELEENYQRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDKYGNVIHLYERDCSIQRRHQKVVEIAPAAHLDSHLRDRLTLDSVNLAKQVGYENAGTVEFLVDK-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQLRVCEGRSLPELGLEQDKIQINGCAIQCRVTTEDPSRGFQPDTGRIEVFRSGEGMGIRLDSASAFQGAIISPHYDSLLVKVIASGKDLPTAATKMHRALTEFRVRGVKVS 460

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BLAST of Pyruvate carboxylase vs. Ensembl Zebrafish
Match: mccc1 (methylcrotonoyl-CoA carboxylase 1 (alpha) [Source:ZFIN;Acc:ZDB-GENE-050208-450])

HSP 1 Score: 363.999 bits (933), Expect = 1.154e-110
Identity = 192/454 (42.29%), Postives = 276/454 (60.79%), Query Frame = 3

Query:  147 KIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAA---YLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEG-MGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEH 1496
            +I KV++ANRGEIA RV R   +MG+RSVA+YS+ D   MH   ADE+Y IG    P A+   YL + +I+ ++K     A+HPGYGFLSE ++FA  C + GI FIGPP+  +R MG K  ++     A V ++ G  G  Q+         + G P+++KA  GGGG+GMR+ +      E    A+ EA  +F +  M IEKF+E PRH+EVQ+ GD++G+AV+LFERDCSVQRRHQKI+E AP P ++  +R K+   AV+ AK V Y  AGTVEF+ D      YF+E+N RLQVEH V+E +TG DLV  Q+ +A G+ LP   L+QE+I   G++ + RI  EDP  +F P +G L    +  G    R+++     G  +S +YD ++ K++    +   A  K+   LR++ + G+ TNI FL ++  +  F  G+V T FI +H
Sbjct:   35 RIEKVVIANRGEIACRVMRTARKMGVRSVAVYSDADRHSMHVAMADEAYHIG----PAASQQSYLCMDKILDVAKKSSAQAVHPGYGFLSENTEFAEQCKQEGIIFIGPPSSAIRDMGIKSTSKHIMSAAGVPIIEGYHGDDQSDARLQSEAARIGYPVMIKAVRGGGGKGMRIAQSEAEFHEQLESARREARKSFNDDVMLIEKFVENPRHVEVQVFGDQYGDAVYLFERDCSVQRRHQKIIEEAPGPGISPEVRRKLGEAAVRAAKAVNYVGAGTVEFIMD-AQHNFYFMEMNTRLQVEHPVSEMITGTDLVEWQLRVAAGEKLP---LSQEQIELRGHSFEARIYAEDPNNNFLPGAGPLLHLSTPPGDHNTRIETG-VREGDEVSAHYDPMIAKLVVWGEDRSAALKKLRYCLRQYNIVGLNTNIDFLLSLSGHPEFEAGNVHTSFIPQH 479

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BLAST of Pyruvate carboxylase vs. Ensembl Xenopus
Match: hoxd3 (homeobox D3 [Source:Xenbase;Acc:XB-GENE-478462])

HSP 1 Score: 1557.73 bits (4032), Expect = 0.000e+0
Identity = 771/1155 (66.75%), Postives = 936/1155 (81.04%), Query Frame = 3

Query:  117 YKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            ++S Q +  K I+KVLVANRGEIA RVFRAC E+GIR+VA+YSEQDT QMHR KADE+Y+IGKGL PV AYLNI +IIK++K ++VDA+HPGYGFLSERSDFA AC +AG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI    EA EF  KYG PII KAAYGGGGRGMRVV+  E L EN+TRA SEAL+AFGNG +F+EKFIE+PRHIEVQILGDKFGN +HL+ERDCS+QRRHQK+VEIAPA  L   +RD++  D+VKLAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +QI IAEGKSLPELGL QE IR  G AIQCR+TTEDP+R FQPD+GR+EVFRSGEGMGIRLDSASAF GA+ISP+YDSLL+KVIAH  + ++A  KM R+L EFR+RGVKTNIPFL NVL N +FL+G+VDT FIDE+P+LF  K  QNRAQKLL YLG +MVNGP T +    KPS ++P +P  P+      G+RDIL++ GP+ FA+A+R+H G L+MDTTFRDAHQSLLATRVRT+D+  I+PFV+ NF NLFSLENWGGATFDV+MRFL ECPW RL+ LR+LIPNIPFQMLLRGANAVGYTNYPDN V+KFC++A ++GMDIFRVFD LNYLPN+I+GM+A  +AGGVVEA+  Y+GD+ DPT+TKY L YY+ LA++LVK G HIL IKDMAG+LKP ++ +LI  LR ++P+IPIH+H+HDTAGAGVA+MLA A +G DIVD A+DSMSG+TSQPSMGA+VAC + T  DTG+ LEK++ YS YWE AR LY  F+CT TM+SGNADVY N+IPGGQYTNL FQ+ S+GL ++F+EVK+ YA AN +LGDVIKVTPSSKIVGDLAQFMV N ++ + +   ADELS P SV+E+ QG+VG PYGGFPE  RSKV+K+   I GRPG  L + DF   + +L   ++ D   +DIMS A+YP VF+E++ F  +FGPV  L TR+FL GP+IAEE  V+LE+GKTLHIK LAL D+  +G REVFFELNGQLRSV + D +A K +   PKA K V+G +G+PMPG+V+++KVKEG  V+KGQ LC++SAMKME  VNSPV G VK V+V   M +EGEDL++EIE
Sbjct:   63 FQSTQRVDYKPIKKVLVANRGEIATRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAYIIGKGLPPVQAYLNIPDIIKVAKENEVDAVHPGYGFLSERSDFAQACTDAGVRFIGPSPEVVRKMGDKVEARAIAISAGVPVVPGTDSPISCLTEAKEFSNKYGFPIIFKAAYGGGGRGMRVVRSYEELEENYTRAYSEALSAFGNGALFVEKFIEKPRHIEVQILGDKFGNVIHLYERDCSIQRRHQKVVEIAPAAQLDPQLRDRLTHDSVKLAKQVGYENAGTVEFLVDK-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHIAEGKSLPELGLKQENIRINGCAIQCRVTTEDPSRGFQPDTGRIEVFRSGEGMGIRLDSASAFQGAVISPHYDSLLVKVIAHGKDQQVAATKMSRALAEFRIRGVKTNIPFLQNVLNNNQFLHGTVDTQFIDENPDLFNLKPVQNRAQKLLHYLGHVMVNGPTTPIPVKAKPSSVDPVVPPIPMNDPP-PGFRDILLREGPEGFAKAIRQHKGLLLMDTTFRDAHQSLLATRVRTHDLKNIAPFVSHNFNNLFSLENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNAVFKFCEVAKENGMDIFRVFDSLNYLPNMILGMEAAGRAGGVVEAAISYTGDVADPTRTKYTLDYYVNLAEELVKAGTHILCIKDMAGLLKPKSSDMLIRALRDRFPNIPIHVHTHDTAGAGVASMLACAHAGADIVDVAVDSMSGMTSQPSMGALVACAKGTDQDTGIQLEKVFDYSEYWEVARGLYSAFDCTATMKSGNADVYENEIPGGQYTNLHFQAHSMGLGNKFKEVKKAYAEANKILGDVIKVTPSSKIVGDLAQFMVHNGLNREQVETMADELSFPLSVVEYMQGYVGIPYGGFPEPFRSKVLKDLPRIEGRPGASLPSMDFTKLEEKLKSKYD-DITPEDIMSAAMYPKVFEEYKDFGSQFGPVECLNTRLFLEGPKIAEEFEVELERGKTLHIKALALGDLNKAGQREVFFELNGQLRSVLVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVKEGTKVEKGQPLCVLSAMKMETLVNSPVTGTVKKVYVKTDMHLEGEDLLLEIE 1214

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BLAST of Pyruvate carboxylase vs. Ensembl Xenopus
Match: hoxd3 (homeobox D3 [Source:Xenbase;Acc:XB-GENE-478462])

HSP 1 Score: 1541.94 bits (3991), Expect = 0.000e+0
Identity = 761/1137 (66.93%), Postives = 922/1137 (81.09%), Query Frame = 3

Query:  171 NRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            N GEIA RVFRAC E+GIR+VA+YSEQDT QMHR KADE+Y+IGKGL PV AYLNI +IIK++K ++VDA+HPGYGFLSERSDFA AC +AG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI    EA EF  KYG PII KAAYGGGGRGMRVV+  E L EN+TRA SEAL+AFGNG +F+EKFIE+PRHIEVQILGDKFGN +HL+ERDCS+QRRHQK+VEIAPA  L   +RD++  D+VKLAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +QI IAEGKSLPELGL QE IR  G AIQCR+TTEDP+R FQPD+GR+EVFRSGEGMGIRLDSASAF GA+ISP+YDSLL+KVIAH  + ++A  KM R+L EFR+RGVKTNIPFL NVL N +FL+G+VDT FIDE+P+LF  K  QNRAQKLL YLG +MVNGP T +    KPS ++P +P  P+      G+RDIL++ GP+ FA+A+R+H G L+MDTTFRDAHQSLLATRVRT+D+  I+PFV+ NF NLFSLENWGGATFDV+MRFL ECPW RL+ LR+LIPNIPFQMLLRGANAVGYTNYPDN V+KFC++A ++GMDIFRVFD LNYLPN+I+GM+A  +AGGVVEA+  Y+GD+ DPT+TKY L YY+ LA++LVK G HIL IKDMAG+LKP ++ +LI  LR ++P+IPIH+H+HDTAGAGVA+MLA A +G DIVD A+DSMSG+TSQPSMGA+VAC + T  DTG+ LEK++ YS YWE AR LY  F+CT TM+SGNADVY N+IPGGQYTNL FQ+ S+GL ++F+EVK+ YA AN +LGDVIKVTPSSKIVGDLAQFMV N ++ + +   ADELS P SV+E+ QG+VG PYGGFPE  RSKV+K+   I GRPG  L + DF   + +L   ++ D   +DIMS A+YP VF+E++ F  +FGPV  L TR+FL GP+IAEE  V+LE+GKTLHIK LAL D+  +G REVFFELNGQLRSV + D +A K +   PKA K V+G +G+PMPG+V+++KVKEG  V+KGQ LC++SAMKME  VNSPV G VK V+V   M +EGEDL++EIE
Sbjct:   35 NTGEIATRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAYIIGKGLPPVQAYLNIPDIIKVAKENEVDAVHPGYGFLSERSDFAQACTDAGVRFIGPSPEVVRKMGDKVEARAIAISAGVPVVPGTDSPISCLTEAKEFSNKYGFPIIFKAAYGGGGRGMRVVRSYEELEENYTRAYSEALSAFGNGALFVEKFIEKPRHIEVQILGDKFGNVIHLYERDCSIQRRHQKVVEIAPAAQLDPQLRDRLTHDSVKLAKQVGYENAGTVEFLVDK-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHIAEGKSLPELGLKQENIRINGCAIQCRVTTEDPSRGFQPDTGRIEVFRSGEGMGIRLDSASAFQGAVISPHYDSLLVKVIAHGKDQQVAATKMSRALAEFRIRGVKTNIPFLQNVLNNNQFLHGTVDTQFIDENPDLFNLKPVQNRAQKLLHYLGHVMVNGPTTPIPVKAKPSSVDPVVPPIPMNDPP-PGFRDILLREGPEGFAKAIRQHKGLLLMDTTFRDAHQSLLATRVRTHDLKNIAPFVSHNFNNLFSLENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNAVFKFCEVAKENGMDIFRVFDSLNYLPNMILGMEAAGRAGGVVEAAISYTGDVADPTRTKYTLDYYVNLAEELVKAGTHILCIKDMAGLLKPKSSDMLIRALRDRFPNIPIHVHTHDTAGAGVASMLACAHAGADIVDVAVDSMSGMTSQPSMGALVACAKGTDQDTGIQLEKVFDYSEYWEVARGLYSAFDCTATMKSGNADVYENEIPGGQYTNLHFQAHSMGLGNKFKEVKKAYAEANKILGDVIKVTPSSKIVGDLAQFMVHNGLNREQVETMADELSFPLSVVEYMQGYVGIPYGGFPEPFRSKVLKDLPRIEGRPGASLPSMDFTKLEEKLKSKYD-DITPEDIMSAAMYPKVFEEYKDFGSQFGPVECLNTRLFLEGPKIAEEFEVELERGKTLHIKALALGDLNKAGQREVFFELNGQLRSVLVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVKEGTKVEKGQPLCVLSAMKMETLVNSPVTGTVKKVYVKTDMHLEGEDLLLEIE 1168

[Close]

BLAST of Pyruvate carboxylase vs. Ensembl Xenopus
Match: hoxd3 (homeobox D3 [Source:Xenbase;Acc:XB-GENE-478462])

HSP 1 Score: 1540.78 bits (3988), Expect = 0.000e+0
Identity = 761/1137 (66.93%), Postives = 922/1137 (81.09%), Query Frame = 3

Query:  171 NRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            N GEIA RVFRAC E+GIR+VA+YSEQDT QMHR KADE+Y+IGKGL PV AYLNI +IIK++K ++VDA+HPGYGFLSERSDFA AC +AG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI    EA EF  KYG PII KAAYGGGGRGMRVV+  E L EN+TRA SEAL+AFGNG +F+EKFIE+PRHIEVQILGDKFGN +HL+ERDCS+QRRHQK+VEIAPA  L   +RD++  D+VKLAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +QI IAEGKSLPELGL QE IR  G AIQCR+TTEDP+R FQPD+GR+EVFRSGEGMGIRLDSASAF GA+ISP+YDSLL+KVIAH  + ++A  KM R+L EFR+RGVKTNIPFL NVL N +FL+G+VDT FIDE+P+LF  K  QNRAQKLL YLG +MVNGP T +    KPS ++P +P  P+      G+RDIL++ GP+ FA+A+R+H G L+MDTTFRDAHQSLLATRVRT+D+  I+PFV+ NF NLFSLENWGGATFDV+MRFL ECPW RL+ LR+LIPNIPFQMLLRGANAVGYTNYPDN V+KFC++A ++GMDIFRVFD LNYLPN+I+GM+A  +AGGVVEA+  Y+GD+ DPT+TKY L YY+ LA++LVK G HIL IKDMAG+LKP ++ +LI  LR ++P+IPIH+H+HDTAGAGVA+MLA A +G DIVD A+DSMSG+TSQPSMGA+VAC + T  DTG+ LEK++ YS YWE AR LY  F+CT TM+SGNADVY N+IPGGQYTNL FQ+ S+GL ++F+EVK+ YA AN +LGDVIKVTPSSKIVGDLAQFMV N ++ + +   ADELS P SV+E+ QG+VG PYGGFPE  RSKV+K+   I GRPG  L + DF   + +L   ++ D   +DIMS A+YP VF+E++ F  +FGPV  L TR+FL GP+IAEE  V+LE+GKTLHIK LAL D+  +G REVFFELNGQLRSV + D +A K +   PKA K V+G +G+PMPG+V+++KVKEG  V+KGQ LC++SAMKME  VNSPV G VK V+V   M +EGEDL++EIE
Sbjct:   38 NTGEIATRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAYIIGKGLPPVQAYLNIPDIIKVAKENEVDAVHPGYGFLSERSDFAQACTDAGVRFIGPSPEVVRKMGDKVEARAIAISAGVPVVPGTDSPISCLTEAKEFSNKYGFPIIFKAAYGGGGRGMRVVRSYEELEENYTRAYSEALSAFGNGALFVEKFIEKPRHIEVQILGDKFGNVIHLYERDCSIQRRHQKVVEIAPAAQLDPQLRDRLTHDSVKLAKQVGYENAGTVEFLVDK-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHIAEGKSLPELGLKQENIRINGCAIQCRVTTEDPSRGFQPDTGRIEVFRSGEGMGIRLDSASAFQGAVISPHYDSLLVKVIAHGKDQQVAATKMSRALAEFRIRGVKTNIPFLQNVLNNNQFLHGTVDTQFIDENPDLFNLKPVQNRAQKLLHYLGHVMVNGPTTPIPVKAKPSSVDPVVPPIPMNDPP-PGFRDILLREGPEGFAKAIRQHKGLLLMDTTFRDAHQSLLATRVRTHDLKNIAPFVSHNFNNLFSLENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNAVFKFCEVAKENGMDIFRVFDSLNYLPNMILGMEAAGRAGGVVEAAISYTGDVADPTRTKYTLDYYVNLAEELVKAGTHILCIKDMAGLLKPKSSDMLIRALRDRFPNIPIHVHTHDTAGAGVASMLACAHAGADIVDVAVDSMSGMTSQPSMGALVACAKGTDQDTGIQLEKVFDYSEYWEVARGLYSAFDCTATMKSGNADVYENEIPGGQYTNLHFQAHSMGLGNKFKEVKKAYAEANKILGDVIKVTPSSKIVGDLAQFMVHNGLNREQVETMADELSFPLSVVEYMQGYVGIPYGGFPEPFRSKVLKDLPRIEGRPGASLPSMDFTKLEEKLKSKYD-DITPEDIMSAAMYPKVFEEYKDFGSQFGPVECLNTRLFLEGPKIAEEFEVELERGKTLHIKALALGDLNKAGQREVFFELNGQLRSVLVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVKEGTKVEKGQPLCVLSAMKMETLVNSPVTGTVKKVYVKTDMHLEGEDLLLEIE 1171

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BLAST of Pyruvate carboxylase vs. Ensembl Xenopus
Match: hoxd3 (homeobox D3 [Source:Xenbase;Acc:XB-GENE-478462])

HSP 1 Score: 1540.4 bits (3987), Expect = 0.000e+0
Identity = 761/1137 (66.93%), Postives = 922/1137 (81.09%), Query Frame = 3

Query:  171 NRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            N GEIA RVFRAC E+GIR+VA+YSEQDT QMHR KADE+Y+IGKGL PV AYLNI +IIK++K ++VDA+HPGYGFLSERSDFA AC +AG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI    EA EF  KYG PII KAAYGGGGRGMRVV+  E L EN+TRA SEAL+AFGNG +F+EKFIE+PRHIEVQILGDKFGN +HL+ERDCS+QRRHQK+VEIAPA  L   +RD++  D+VKLAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +QI IAEGKSLPELGL QE IR  G AIQCR+TTEDP+R FQPD+GR+EVFRSGEGMGIRLDSASAF GA+ISP+YDSLL+KVIAH  + ++A  KM R+L EFR+RGVKTNIPFL NVL N +FL+G+VDT FIDE+P+LF  K  QNRAQKLL YLG +MVNGP T +    KPS ++P +P  P+      G+RDIL++ GP+ FA+A+R+H G L+MDTTFRDAHQSLLATRVRT+D+  I+PFV+ NF NLFSLENWGGATFDV+MRFL ECPW RL+ LR+LIPNIPFQMLLRGANAVGYTNYPDN V+KFC++A ++GMDIFRVFD LNYLPN+I+GM+A  +AGGVVEA+  Y+GD+ DPT+TKY L YY+ LA++LVK G HIL IKDMAG+LKP ++ +LI  LR ++P+IPIH+H+HDTAGAGVA+MLA A +G DIVD A+DSMSG+TSQPSMGA+VAC + T  DTG+ LEK++ YS YWE AR LY  F+CT TM+SGNADVY N+IPGGQYTNL FQ+ S+GL ++F+EVK+ YA AN +LGDVIKVTPSSKIVGDLAQFMV N ++ + +   ADELS P SV+E+ QG+VG PYGGFPE  RSKV+K+   I GRPG  L + DF   + +L   ++ D   +DIMS A+YP VF+E++ F  +FGPV  L TR+FL GP+IAEE  V+LE+GKTLHIK LAL D+  +G REVFFELNGQLRSV + D +A K +   PKA K V+G +G+PMPG+V+++KVKEG  V+KGQ LC++SAMKME  VNSPV G VK V+V   M +EGEDL++EIE
Sbjct:   31 NTGEIATRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAYIIGKGLPPVQAYLNIPDIIKVAKENEVDAVHPGYGFLSERSDFAQACTDAGVRFIGPSPEVVRKMGDKVEARAIAISAGVPVVPGTDSPISCLTEAKEFSNKYGFPIIFKAAYGGGGRGMRVVRSYEELEENYTRAYSEALSAFGNGALFVEKFIEKPRHIEVQILGDKFGNVIHLYERDCSIQRRHQKVVEIAPAAQLDPQLRDRLTHDSVKLAKQVGYENAGTVEFLVDK-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHIAEGKSLPELGLKQENIRINGCAIQCRVTTEDPSRGFQPDTGRIEVFRSGEGMGIRLDSASAFQGAVISPHYDSLLVKVIAHGKDQQVAATKMSRALAEFRIRGVKTNIPFLQNVLNNNQFLHGTVDTQFIDENPDLFNLKPVQNRAQKLLHYLGHVMVNGPTTPIPVKAKPSSVDPVVPPIPMNDPP-PGFRDILLREGPEGFAKAIRQHKGLLLMDTTFRDAHQSLLATRVRTHDLKNIAPFVSHNFNNLFSLENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNAVFKFCEVAKENGMDIFRVFDSLNYLPNMILGMEAAGRAGGVVEAAISYTGDVADPTRTKYTLDYYVNLAEELVKAGTHILCIKDMAGLLKPKSSDMLIRALRDRFPNIPIHVHTHDTAGAGVASMLACAHAGADIVDVAVDSMSGMTSQPSMGALVACAKGTDQDTGIQLEKVFDYSEYWEVARGLYSAFDCTATMKSGNADVYENEIPGGQYTNLHFQAHSMGLGNKFKEVKKAYAEANKILGDVIKVTPSSKIVGDLAQFMVHNGLNREQVETMADELSFPLSVVEYMQGYVGIPYGGFPEPFRSKVLKDLPRIEGRPGASLPSMDFTKLEEKLKSKYD-DITPEDIMSAAMYPKVFEEYKDFGSQFGPVECLNTRLFLEGPKIAEEFEVELERGKTLHIKALALGDLNKAGQREVFFELNGQLRSVLVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVKEGTKVEKGQPLCVLSAMKMETLVNSPVTGTVKKVYVKTDMHLEGEDLLLEIE 1164

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BLAST of Pyruvate carboxylase vs. Ensembl Xenopus
Match: hoxd3 (homeobox D3 [Source:Xenbase;Acc:XB-GENE-478462])

HSP 1 Score: 1330.08 bits (3441), Expect = 0.000e+0
Identity = 654/944 (69.28%), Postives = 783/944 (82.94%), Query Frame = 3

Query:  117 YKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKV 2948
            ++S Q +  K I+KVLVANRGEIA RVFRAC E+GIR+VA+YSEQDT QMHR KADE+Y+IGKGL PV AYLNI +IIK++K ++VDA+HPGYGFLSERSDFA AC +AG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI    EA EF  KYG PII KAAYGGGGRGMRVV+  E L EN+TRA SEAL+AFGNG +F+EKFIE+PRHIEVQILGDKFGN +HL+ERDCS+QRRHQK+VEIAPA  L   +RD++  D+VKLAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +QI IAEGKSLPELGL QE IR  G AIQCR+TTEDP+R FQPD+GR+EVFRSGEGMGIRLDSASAF GA+ISP+YDSLL+KVIAH  + ++A  KM R+L EFR+RGVKTNIPFL NVL N +FL+G+VDT FIDE+P+LF  K  QNRAQKLL YLG +MVNGP T +    KPS ++P +P  P+      G+RDIL++ GP+ FA+A+R+H G L+MDTTFRDAHQSLLATRVRT+D+  I+PFV+ NF NLFSLENWGGATFDV+MRFL ECPW RL+ LR+LIPNIPFQMLLRGANAVGYTNYPDN V+KFC++A ++GMDIFRVFD LNYLPN+I+GM+A  +AGGVVEA+  Y+GD+ DPT+TKY L YY+ LA++LVK G HIL IKDMAG+LKP ++ +LI  LR ++P+IPIH+H+HDTAGAGVA+MLA A +G DIVD A+DSMSG+TSQPSMGA+VAC + T  DTG+ LEK++ YS YWE AR LY  F+CT TM+SGNADVY N+IPGGQYTNL FQ+ S+GL ++F+EVK+ YA AN +LGDVIKVTPSSKIVGDLAQFMV N ++ + +   ADELS P SV+E+ QG+VG PYGGFPE  RSKV
Sbjct:   26 FQSTQRVDYKPIKKVLVANRGEIATRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAYIIGKGLPPVQAYLNIPDIIKVAKENEVDAVHPGYGFLSERSDFAQACTDAGVRFIGPSPEVVRKMGDKVEARAIAISAGVPVVPGTDSPISCLTEAKEFSNKYGFPIIFKAAYGGGGRGMRVVRSYEELEENYTRAYSEALSAFGNGALFVEKFIEKPRHIEVQILGDKFGNVIHLYERDCSIQRRHQKVVEIAPAAQLDPQLRDRLTHDSVKLAKQVGYENAGTVEFLVDK-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHIAEGKSLPELGLKQENIRINGCAIQCRVTTEDPSRGFQPDTGRIEVFRSGEGMGIRLDSASAFQGAVISPHYDSLLVKVIAHGKDQQVAATKMSRALAEFRIRGVKTNIPFLQNVLNNNQFLHGTVDTQFIDENPDLFNLKPVQNRAQKLLHYLGHVMVNGPTTPIPVKAKPSSVDPVVPPIPMNDPP-PGFRDILLREGPEGFAKAIRQHKGLLLMDTTFRDAHQSLLATRVRTHDLKNIAPFVSHNFNNLFSLENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNAVFKFCEVAKENGMDIFRVFDSLNYLPNMILGMEAAGRAGGVVEAAISYTGDVADPTRTKYTLDYYVNLAEELVKAGTHILCIKDMAGLLKPKSSDMLIRALRDRFPNIPIHVHTHDTAGAGVASMLACAHAGADIVDVAVDSMSGMTSQPSMGALVACAKGTDQDTGIQLEKVFDYSEYWEVARGLYSAFDCTATMKSGNADVYENEIPGGQYTNLHFQAHSMGLGNKFKEVKKAYAEANKILGDVIKVTPSSKIVGDLAQFMVHNGLNREQVETMADELSFPLSVVEYMQGYVGIPYGGFPEPFRSKV 967

HSP 2 Score: 166.392 bits (420), Expect = 4.846e-41
Identity = 80/129 (62.02%), Postives = 101/129 (78.29%), Query Frame = 3

Query: 3195 VDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            V+LE+GKTLHIK LAL D+  +G REVFFELNGQLRSV + D +A K +   PKA K V+G +G+PMPG+V+++KVKEG  V+KGQ LC++SAMKME  VNSPV G VK V+V   M +EGEDL++EIE
Sbjct:  967 VELERGKTLHIKALALGDLNKAGQREVFFELNGQLRSVLVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVKEGTKVEKGQPLCVLSAMKMETLVNSPVTGTVKKVYVKTDMHLEGEDLLLEIE 1095

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BLAST of Pyruvate carboxylase vs. Ensembl Mouse
Match: Pcx (pyruvate carboxylase [Source:MGI Symbol;Acc:MGI:97520])

HSP 1 Score: 1517.29 bits (3927), Expect = 0.000e+0
Identity = 739/1149 (64.32%), Postives = 925/1149 (80.50%), Query Frame = 3

Query:  135 LTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            L  K I+KV+VANRGEIAIRVFRAC E+GIR+VA+YSEQDT QMHR KADE+YLIG+GL PV AYL+I +IIK++K + VDA+HPGYGFLSER+DFA AC +AG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI +  EA EF   YG PII KAAYGGGGRGMRVV   E L EN+TRA SEALAAFGNG +F+EKFIE+PRHIEVQILGD++GN +HL+ERDCS+QRRHQK+VEIAPA +L   +R ++ SD+VKLAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +QI ++EG+SLP+LGL QE IR  G AIQCR+TTEDPAR FQPD+GR+EVFRSGEGMGIRLD+ASAF GA+ISP+YDSLL+KVIAH  +   A  KM R+L EFRVRGVKTNIPFL NVL N++FL G+VDT FIDE+P LFQ + +QNRAQKLL YLG +MVNGP T +  ++ PS ++P +P  PI      G+RDIL++ GP+ FA+AVR H G L+MDTTFRDAHQSLLATRVRT+D+ +I+P+VA NF  LFS+ENWGGATFDV+MRFL ECPW RL+ LR+LIPNIPFQMLLRGANAVGYTNYPDN+V+KFC++A ++GMD+FRVFD LNYLPN+++GM+A   AGGVVEA+  Y+GD+ DP++TKY+L YY+ LA++LV+ G HIL IKDMAG+LKP A  +L+  LR ++PD+P+H+H+HDT+GAGVA MLA A++G D+VD A+DSMSG+TSQPSMGA+VAC + TPLDT + LE+++ YS YWE AR LY  F+CT TM+SGN+DVY N+IPGGQYTNL FQ+ S+GL  +F+EVK+ Y  AN +LGD+IKVTPSSKIVGDLAQFMVQN +       +A+ELS P+SV+EF QG++G P+GGFPE  RSKV+K+   I GRPG  L   + +  + +L D    +   +D++S A+YP VF +F+ F   FGP+  L TR+FL GP+IAEE  V+LE+GKTLHIK LA+SD+  +G R+VFFELNGQLRS+ + D +A K +   PKA K V+G +G+PMPG+V+++KV  GD V KGQ LC++SAMKME  V SP++G ++ VHV   M +EG+DL++EIE
Sbjct:   33 LEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENGVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDSPISSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPATHLDPQLRSRLTSDSVKLAKQVGYENAGTVEFLVDK-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVSEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIPFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVNVSPSPVDPAVPVVPIGPPP-AGFRDILLREGPEGFARAVRNHQGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFNKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLEYYMGLAEELVRAGTHILCIKDMAGLLKPAACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAVDSMSGMTSQPSMGALVACTKGTPLDTEVPLERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGIPHGGFPEPFRSKVLKDLPRIEGRPGASLPPLNLKELEKDLIDRHGEEVTPEDVLSAAMYPDVFAQFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVAAGDKVAKGQPLCVLSAMKMETVVTSPMEGTIRKVHVTKDMTLEGDDLILEIE 1179

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BLAST of Pyruvate carboxylase vs. Ensembl Mouse
Match: Pcx (pyruvate carboxylase [Source:MGI Symbol;Acc:MGI:97520])

HSP 1 Score: 1516.52 bits (3925), Expect = 0.000e+0
Identity = 739/1149 (64.32%), Postives = 925/1149 (80.50%), Query Frame = 3

Query:  135 LTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            L  K I+KV+VANRGEIAIRVFRAC E+GIR+VA+YSEQDT QMHR KADE+YLIG+GL PV AYL+I +IIK++K + VDA+HPGYGFLSER+DFA AC +AG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI +  EA EF   YG PII KAAYGGGGRGMRVV   E L EN+TRA SEALAAFGNG +F+EKFIE+PRHIEVQILGD++GN +HL+ERDCS+QRRHQK+VEIAPA +L   +R ++ SD+VKLAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +QI ++EG+SLP+LGL QE IR  G AIQCR+TTEDPAR FQPD+GR+EVFRSGEGMGIRLD+ASAF GA+ISP+YDSLL+KVIAH  +   A  KM R+L EFRVRGVKTNIPFL NVL N++FL G+VDT FIDE+P LFQ + +QNRAQKLL YLG +MVNGP T +  ++ PS ++P +P  PI      G+RDIL++ GP+ FA+AVR H G L+MDTTFRDAHQSLLATRVRT+D+ +I+P+VA NF  LFS+ENWGGATFDV+MRFL ECPW RL+ LR+LIPNIPFQMLLRGANAVGYTNYPDN+V+KFC++A ++GMD+FRVFD LNYLPN+++GM+A   AGGVVEA+  Y+GD+ DP++TKY+L YY+ LA++LV+ G HIL IKDMAG+LKP A  +L+  LR ++PD+P+H+H+HDT+GAGVA MLA A++G D+VD A+DSMSG+TSQPSMGA+VAC + TPLDT + LE+++ YS YWE AR LY  F+CT TM+SGN+DVY N+IPGGQYTNL FQ+ S+GL  +F+EVK+ Y  AN +LGD+IKVTPSSKIVGDLAQFMVQN +       +A+ELS P+SV+EF QG++G P+GGFPE  RSKV+K+   I GRPG  L   + +  + +L D    +   +D++S A+YP VF +F+ F   FGP+  L TR+FL GP+IAEE  V+LE+GKTLHIK LA+SD+  +G R+VFFELNGQLRS+ + D +A K +   PKA K V+G +G+PMPG+V+++KV  GD V KGQ LC++SAMKME  V SP++G ++ VHV   M +EG+DL++EIE
Sbjct:   32 LEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENGVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDSPISSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPATHLDPQLRSRLTSDSVKLAKQVGYENAGTVEFLVDK-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVSEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIPFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVNVSPSPVDPAVPVVPIGPPP-AGFRDILLREGPEGFARAVRNHQGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFNKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLEYYMGLAEELVRAGTHILCIKDMAGLLKPAACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAVDSMSGMTSQPSMGALVACTKGTPLDTEVPLERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGIPHGGFPEPFRSKVLKDLPRIEGRPGASLPPLNLKELEKDLIDRHGEEVTPEDVLSAAMYPDVFAQFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVAAGDKVAKGQPLCVLSAMKMETVVTSPMEGTIRKVHVTKDMTLEGDDLILEIE 1178

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Query:  135 LTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            L  K I+KV+VANRGEIAIRVFRAC E+GIR+VA+YSEQDT QMHR KADE+YLIG+GL PV AYL+I +IIK++K + VDA+HPGYGFLSER+DFA AC +AG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI +  EA EF   YG PII KAAYGGGGRGMRVV   E L EN+TRA SEALAAFGNG +F+EKFIE+PRHIEVQILGD++GN +HL+ERDCS+QRRHQK+VEIAPA +L   +R ++ SD+VKLAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +QI ++EG+SLP+LGL QE IR  G AIQCR+TTEDPAR FQPD+GR+EVFRSGEGMGIRLD+ASAF GA+ISP+YDSLL+KVIAH  +   A  KM R+L EFRVRGVKTNIPFL NVL N++FL G+VDT FIDE+P LFQ + +QNRAQKLL YLG +MVNGP T +  ++ PS ++P +P  PI      G+RDIL++ GP+ FA+AVR H G L+MDTTFRDAHQSLLATRVRT+D+ +I+P+VA NF  LFS+ENWGGATFDV+MRFL ECPW RL+ LR+LIPNIPFQMLLRGANAVGYTNYPDN+V+KFC++A ++GMD+FRVFD LNYLPN+++GM+A   AGGVVEA+  Y+GD+ DP++TKY+L YY+ LA++LV+ G HIL IKDMAG+LKP A  +L+  LR ++PD+P+H+H+HDT+GAGVA MLA A++G D+VD A+DSMSG+TSQPSMGA+VAC + TPLDT + LE+++ YS YWE AR LY  F+CT TM+SGN+DVY N+IPGGQYTNL FQ+ S+GL  +F+EVK+ Y  AN +LGD+IKVTPSSKIVGDLAQFMVQN +       +A+ELS P+SV+EF QG++G P+GGFPE  RSKV+K+   I GRPG  L   + +  + +L D    +   +D++S A+YP VF +F+ F   FGP+  L TR+FL GP+IAEE  V+LE+GKTLHIK LA+SD+  +G R+VFFELNGQLRS+ + D +A K +   PKA K V+G +G+PMPG+V+++KV  GD V KGQ LC++SAMKME  V SP++G ++ VHV   M +EG+DL++EIE
Sbjct:   32 LEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENGVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDSPISSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPATHLDPQLRSRLTSDSVKLAKQVGYENAGTVEFLVDK-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVSEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIPFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVNVSPSPVDPAVPVVPIGPPP-AGFRDILLREGPEGFARAVRNHQGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFNKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLEYYMGLAEELVRAGTHILCIKDMAGLLKPAACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAVDSMSGMTSQPSMGALVACTKGTPLDTEVPLERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGIPHGGFPEPFRSKVLKDLPRIEGRPGASLPPLNLKELEKDLIDRHGEEVTPEDVLSAAMYPDVFAQFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVAAGDKVAKGQPLCVLSAMKMETVVTSPMEGTIRKVHVTKDMTLEGDDLILEIE 1178

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BLAST of Pyruvate carboxylase vs. Ensembl Mouse
Match: Mccc1 (methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) [Source:MGI Symbol;Acc:MGI:1919289])

HSP 1 Score: 361.303 bits (926), Expect = 1.816e-109
Identity = 200/450 (44.44%), Postives = 277/450 (61.56%), Query Frame = 3

Query:  150 IRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRL-EVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEH 1496
            I KVL+ANRGEIA RV R   +MG++SVA+YSE D   MH   ADE+Y IG       +YL + +II+++K     AIHPGYGFLSE  +FA  C + GI FIGPP+  +R MG K  ++     A V VV G  G  Q+ +   E   K G P+++KA  GGGG+GMR+V+      E    A+ EA  +F +  M IEKF++ PRH+EVQ+ GD  GNAV+LFERDCSVQRRHQKI+E APAP +   +R K+   AV+ AK V Y  AGTVEF+ D      YF+E+N RLQVEH VTE +TG DLV  Q+ IA G+ +P   L+QEEI   G+A + RI  EDP  +F P +G L  +      M  R+++     G  +S +YD ++ K++  A++ + A +K+   L ++ + G+++N+ FL  +  +  F  G+V T FI +H
Sbjct:   45 ITKVLIANRGEIACRVIRTAKKMGVQSVAVYSEADRNSMHVDMADEAYSIGPAPSQ-QSYLAMEKIIQVAKSSAAQAIHPGYGFLSENMEFAELCKQEGIIFIGPPSSAIRDMGIKSTSKSIMAAAGVPVVEGYHGKDQSDQCLREHAGKIGYPVMIKAVRGGGGKGMRIVRSEREFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGINPEVRRKLGEAAVRAAKAVKYVGAGTVEFIMDS-RHNFYFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIP---LSQEEIPLQGHAFEARIYAEDPDNNFMPGAGPLVHLSTPSADMSTRIETG-VRQGDEVSVHYDPMIAKLVVWASDRQSALSKLRYCLHQYNIVGLRSNVDFLLRLSGHPEFEAGNVHTDFIPQH 488

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BLAST of Pyruvate carboxylase vs. Ensembl Mouse
Match: Pcca (propionyl-Coenzyme A carboxylase, alpha polypeptide [Source:MGI Symbol;Acc:MGI:97499])

HSP 1 Score: 351.288 bits (900), Expect = 1.011e-105
Identity = 197/461 (42.73%), Postives = 290/461 (62.91%), Query Frame = 3

Query:  141 QKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVA-AYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQ-PDSGRLEVFRSGEGM-GIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFI-DEHPNLFQ 1511
            +K   K+L+ANRGEIA RV + C +MGI++VAI+S+ D   +H   ADE+  +G    P + +YLN+  I++  K     A+HPGYGFLSE  +FA       + FIGP    ++ MGDK+E++  A  A V  +PG  G ++  +EA+   ++ G P+++KA+ GGGG+GMR+  + E   + F  +  EA ++FG+  + IEKFI+ PRHIE+Q+LGDK GNA+ L ER+CS+QRR+QK+VE AP+  L    R  M   AV LAK V Y +AGTVEFL D   +  YF+E+N RLQVEH VTE +TG+DLV+  IL+A+G  L      QE+I   G+A++CR+  EDP + F  P  GRL  ++    + G+R+DS     G+ IS YYD ++ K++ + ++   A  +M  +L  + +RGV  NIP L  V+ N RF+ G + T F+ D +P+ F+
Sbjct:   56 EKTFDKILIANRGEIACRVIKTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPA--PTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFAKRLAAEDVTFIGPDTHAIQAMGDKIESKLLAKRAKVNTIPGFDGVVKDADEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDPETRQAMGEQAVALAKAVKYSSAGTVEFLVDSQKN-FYFLEMNTRLQVEHPVTECITGLDLVQEMILVAKGYPLRH---KQEDIPISGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPIHLPGVRVDSGIQ-PGSDISIYYDPMISKLVTYGSDRAEALKRMEDALDNYVIRGVTHNIPLLREVIINTRFVKGDISTKFLSDVYPDGFK 509

HSP 2 Score: 65.0846 bits (157), Expect = 5.357e-10
Identity = 38/98 (38.78%), Postives = 58/98 (59.18%), Query Frame = 3

Query: 3291 GQLRSVEIVDKEASKTIR-VRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            G +  V I+ K A++  + +  K  K    ++ SPMPG V+ V VK GD V +GQ +C+I AMKM+ S+ +   GKVK+VH      +   DL++E+E
Sbjct:  627 GTVYKVHILTKLAAELNKFMLEKVPKDTSSTLCSPMPGVVVAVSVKPGDMVAEGQEICVIEAMKMQNSMTAGKMGKVKLVHCKAGDTVGEGDLLVELE 724

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BLAST of Pyruvate carboxylase vs. UniProt/SwissProt
Match: sp|O17732|PYC1_CAEEL (Pyruvate carboxylase 1 OS=Caenorhabditis elegans OX=6239 GN=pyc-1 PE=1 SV=1)

HSP 1 Score: 1600.49 bits (4143), Expect = 0.000e+0
Identity = 774/1156 (66.96%), Postives = 945/1156 (81.75%), Query Frame = 3

Query:  114 NYKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            NY ++ ++  ++  KV+VANRGEIAIRVFRA  E+   SVAIY+EQD   MHRLKADE+YL+GKGL PVAAYL I +II+ +  H++DAIHPGYGFLSERSDFAAAC  AGI FIGP  DV+ +MGDKV ARQAA++A V VVPG+PGPI T +EA+EF K+YG PIILKAAYGGGGRG+R V +LE + E F R+ SEA AAFG+G +F+EKF+ERPRHIEVQ+LGD  GN VHL+ERDCSVQRRHQK+VEIAPAP L   +R+K+L+DA++LA+ VGY+NAGTVEFL DQ    +YFIEVNARLQVEHTVTE++TGVDLV++QI IAEGKSL +L L+QE I++ G AIQCR+TTEDPA+ FQPDSGR+EVFRSGEGMGIRLDSASAFAG++ISP+YDSL++KVIA A N   A AKM+R+L++FR+RGVKTNIPFL NVL    FL+ SVDTYFIDEHP LFQFK SQNRAQKLL YLG + VNGP T LATDLKP++++P IP  P   + PTG RD+LV+ GP  FA+ VR  PGC+I DTTFRDAHQSLLATRVRTYDMA ISPFVAQ+F  LFSLENWGGATFDVSMRFL ECPWERL+TLRKLIPNIPFQ LLRGANA+GY+NYPDN++YKFC+LAV++GMD+FRVFD LNYLPN++VGM+AV KAGGVVEA+  Y+GD+TD ++ KY+L YYL LAD LVK  AHIL IKDMAGVLKP AA++LIG LR K+PDIPIH+H+HDT+GAGVA ML  A++G D+VD A+DSMSG+TSQPSMGA+VA LQ T  DTGL+L+ I  YS+YWE  R+LY PFEC TTM+SGNADVY ++IPGGQYTNLQFQ+FSLGL  QF+EVK+ Y  AN +LGD+IKVTPSSKIVGDLAQFMVQN +  +TLV++AD+LS PKSV++F QG+VG+P  GFPE LR+KV++    + GRPG++ K  D +A K EL +       ++D+MSY+++P VF EF+ FR+++GPV KL TR+FL G  IAEE+ V++E GKTL I+ LA   +   G REVFF+LNGQ+RS+ +VDKEASK I  RP+A   VRG +G+PMPG+VLE+K+KEGD V K Q L ++SAMKMEM ++SP+ G VK +H     K    DL++E+E
Sbjct:   21 NY-ANGVIKPREFNKVMVANRGEIAIRVFRALTELNKTSVAIYAEQDKNSMHRLKADEAYLVGKGLPPVAAYLTIDQIIETALKHNIDAIHPGYGFLSERSDFAAACQNAGIVFIGPSPDVMARMGDKVAARQAAIEAGVQVVPGTPGPITTADEAVEFAKQYGTPIILKAAYGGGGRGIRRVDKLEEVEEAFRRSYSEAQAAFGDGSLFVEKFVERPRHIEVQLLGDHHGNIVHLYERDCSVQRRHQKVVEIAPAPALPEGVREKILADALRLARHVGYQNAGTVEFLVDQ-KGNYYFIEVNARLQVEHTVTEEITGVDLVQAQIRIAEGKSLDDLKLSQETIQTTGSAIQCRVTTEDPAKGFQPDSGRIEVFRSGEGMGIRLDSASAFAGSVISPHYDSLMVKVIASARNHPNAAAKMIRALKKFRIRGVKTNIPFLLNVLRQPSFLDASVDTYFIDEHPELFQFKPSQNRAQKLLNYLGEVKVNGPTTPLATDLKPAVVSPPIPYIPAGAKPPTGLRDVLVQRGPTEFAKEVRSRPGCMITDTTFRDAHQSLLATRVRTYDMAAISPFVAQSFNGLFSLENWGGATFDVSMRFLHECPWERLQTLRKLIPNIPFQCLLRGANAMGYSNYPDNVIYKFCELAVKNGMDVFRVFDSLNYLPNLLVGMEAVGKAGGVVEAAIAYTGDVTDKSRDKYDLKYYLNLADQLVKAQAHILSIKDMAGVLKPEAAKLLIGALRDKFPDIPIHVHTHDTSGAGVAAMLECAKAGADVVDAAVDSMSGMTSQPSMGAIVASLQGTKHDTGLSLDDISKYSAYWESTRQLYAPFECATTMKSGNADVYKHEIPGGQYTNLQFQAFSLGLGPQFDEVKRMYREANLVLGDIIKVTPSSKIVGDLAQFMVQNNLTRETLVDRADDLSFPKSVVDFMQGNVGQPPYGFPEPLRTKVLRGKPKVDGRPGENAKPVDLDAVKVELEEKHGRTLSEEDVMSYSMFPTVFDEFETFRQQYGPVDKLPTRLFLTGLEIAEEVDVEIESGKTLAIQLLAEGKLNKRGEREVFFDLNGQMRSIFVVDKEASKEIVTRPRALPGVRGHIGAPMPGDVLELKIKEGDKVTKKQPLFVLSAMKMEMVIDSPIAGTVKAIHAPQGTKCSAGDLVVEVE 1174

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BLAST of Pyruvate carboxylase vs. UniProt/SwissProt
Match: sp|P11498|PYC_HUMAN (Pyruvate carboxylase, mitochondrial OS=Homo sapiens OX=9606 GN=PC PE=1 SV=2)

HSP 1 Score: 1541.94 bits (3991), Expect = 0.000e+0
Identity = 743/1149 (64.66%), Postives = 922/1149 (80.24%), Query Frame = 3

Query:  135 LTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            L  K I+KV+VANRGEIAIRVFRAC E+GIR+VAIYSEQDT QMHR KADE+YLIG+GL PV AYL+I +IIK++K ++VDA+HPGYGFLSER+DFA AC +AG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI +  EA EF   YG PII KAAYGGGGRGMRVV   E L EN+TRA SEALAAFGNG +F+EKFIE+PRHIEVQILGD++GN +HL+ERDCS+QRRHQK+VEIAPA +L   +R ++ SD+VKLAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +QI +AEG+SLP+LGL QE IR  G AIQCR+TTEDPAR FQPD+GR+EVFRSGEGMGIRLD+ASAF GA+ISP+YDSLL+KVIAH  +   A  KM R+L EFRVRGVKTNI FL NVL N++FL G+VDT FIDE+P LFQ + +QNRAQKLL YLG +MVNGP T +     PS  +P +P  PI    P G+RDIL++ GP+ FA+AVR HPG L+MDTTFRDAHQSLLATRVRT+D+ +I+P+VA NF  LFS+ENWGGATFDV+MRFL ECPW RL+ LR+LIPNIPFQMLLRGANAVGYTNYPDN+V+KFC++A ++GMD+FRVFD LNYLPN+++GM+A   AGGVVEA+  Y+GD+ DP++TKY+L YY+ LA++LV+ G HIL IKDMAG+LKP A  +L+  LR ++PD+P+H+H+HDT+GAGVA MLA A++G D+VD A DSMSG+TSQPSMGA+VAC + TPLDT + +E+++ YS YWE AR LY  F+CT TM+SGN+DVY N+IPGGQYTNL FQ+ S+GL  +F+EVK+ Y  AN +LGD+IKVTPSSKIVGDLAQFMVQN +       +A+ELS P+SV+EF QG++G P+GGFPE  RSKV+K+   + GRPG  L   D +A + EL D    +   +D++S A+YP VF  F+ F   FGP+  L TR+FL GP+IAEE  V+LE+GKTLHIK LA+SD+  +G R+VFFELNGQLRS+ + D +A K +   PKA K V+G +G+PMPG+V+++KV  G  V KGQ LC++SAMKME  V SP++G V+ VHV   M +EG+DL++EIE
Sbjct:   32 LEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDR-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIAFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPP-PAGFRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE 1178

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BLAST of Pyruvate carboxylase vs. UniProt/SwissProt
Match: sp|Q29RK2|PYC_BOVIN (Pyruvate carboxylase, mitochondrial OS=Bos taurus OX=9913 GN=PC PE=2 SV=2)

HSP 1 Score: 1534.62 bits (3972), Expect = 0.000e+0
Identity = 745/1149 (64.84%), Postives = 924/1149 (80.42%), Query Frame = 3

Query:  135 LTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            L  K I+KV+VANRGEIAIRVFRAC E+GIR+VA+YSEQDT QMHR KADE+YLIG+GL PV AYL+I +IIK++K ++VDA+HPGYGFLSER+DFA AC +AG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI +  EA EF   YG PII KAAYGGGGRGMRVV   E L EN+TRA SEALAAFGNG +F+EKFIE+PRHIEVQILGD++GN +HL+ERDCS+QRRHQK+VEIAPA +L   +R ++ SD+VKLAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +QI +AEG+SLP+LGL QE IR  G AIQCR+TTEDPAR FQPD+GR+EVFRSGEGMGIRLD+ASAF GA+ISP+YDSLL+KVIAH  +   A  KM R+L EFRVRGVKTNIPFL NVL N++FL G+VDT FIDE+P LFQ + +QNRAQKLL YLG +MVNGP T +     PS  +P +P  PI     TG+RDIL++ GP+ FA+AVR H G L+MDTTFRDAHQSLLATRVRT+D+ +ISP+VA +F  LFS+ENWGGATFDV+MRFL ECPW RL+ LR+L+PNIPFQMLLRGANAVGYTNYPDN+V+KFC++A ++GMDIFRVFD LNYLPN+++GM+A   AGGVVEA+  Y+GD++DP++TKY+L YY+ LA++LV+ G HIL IKDMAG+LKP A  +L+  LR ++PD+P+H+H+HDT+GAGVA MLA A +G D+VD A DSMSG+TSQPSMGA+VAC + TPLDTG+ LE+++ YS YWE AR LY  F+CT TM+SGN+DVY N+IPGGQYTNL FQ+ S+GL  +F+EVK+ Y  AN +LGD+IKVTPSSKIVGDLAQFMVQN +       +A+ELS P+SV+EF QG++G P+GGFPE LRSKV+K+   + GRPG  L   D +A + EL +    +   +D++S A+YP VF  F+ F   FGP+  L TR+FL GP+IAEE  V+LE+GKTLHIK LA+SD+  +G R+VFFELNGQLRS+ + D +A K +   PKA K V+G +G+PMPG+V+++KV  G  V KGQ LC++SAMKME  V SPV+G V+ VHV   M +EG+DL++EIE
Sbjct:   32 LEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDR-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIPFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPIVPVVPIGPPP-TGFRDILLREGPEGFARAVRNHEGLLLMDTTFRDAHQSLLATRVRTHDLKKISPYVAHSFNKLFSIENWGGATFDVAMRFLYECPWRRLQELRELVPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDIFRVFDSLNYLPNLLLGMEAAGSAGGVVEAAISYTGDVSDPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAHAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTGVPLERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLTRAEAEAQAEELSFPRSVVEFLQGYIGIPHGGFPEPLRSKVLKDLPRVEGRPGASLPPLDLQALEKELTERHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAISDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVAAGAKVTKGQPLCVLSAMKMETVVTSPVEGTVRKVHVTKDMTLEGDDLILEIE 1178

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BLAST of Pyruvate carboxylase vs. UniProt/SwissProt
Match: sp|P52873|PYC_RAT (Pyruvate carboxylase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Pc PE=1 SV=2)

HSP 1 Score: 1519.21 bits (3932), Expect = 0.000e+0
Identity = 738/1149 (64.23%), Postives = 923/1149 (80.33%), Query Frame = 3

Query:  135 LTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            L  K I+KV+VANRGEIAIRVFRAC E+GIR+VA+YSEQDT QMHR KADE+YLIG+GL PV AYL+I +IIK++K + VDA+HPGYGFLSER+DFA AC +AG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI +  EA EF   YG PII KAAYGGGGRGMRVV   E L EN+TRA SEALAAFGNG +F+EKFIE+PRHIEVQILGD++GN +HL+ERDCS+QRRHQK+VEIAPA +L   +R ++ SD+VKLAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +QI ++EG+SLP+LGL QE IR  G AIQCR+TTEDPAR FQPD+GR+EVFRSGEGMGIRLD+ASAF GA+ISP+YDSLL+KVIAH  +   A  KM R+L EFRVRGVKTNIPFL NVL N++FL G VDT FIDE+P LFQ + +QNRAQKLL YLG +MVNGP T +   + PS ++P +P  PI      G+RDIL++ GP+ FA+AVR H G L+MDTTFRDAHQSLLATRVRT+D+ +I+P+VA NF NLFS+ENWGGATFDV+MRFL ECPW RL+ LR+LIPNIPFQMLLRGANAVGYTNYPDN+V+KFC++A ++GMD+FR+FD LNYLPN+++GM+A   AGGVVEA+  Y+GD+ DP++TKY+L YY+ LA++LV+ G HIL IKDMAG+LKP A  +L+  LR ++PD+P+H+H+HDT+G+GVA MLA A++G D+VD A+DSMSG+TSQPSMGA+VAC + TPLDT + LE+++ YS YWE AR LY  F+CT TM+SGN+DVY N+IPGGQYTNL FQ+ S+GL  +F+EVK+ Y  AN +LGD+IKVTPSSKIVGDLAQFMVQN +       +A+ELS P+SV+EF QG++G P+GGFPE  RSKV+K+   I GRPG  L   + +  + +L D    +   +D++S A+YP VF +F+ F   FGP+  L TR+FL GP+IAEE  V+LE+GKTLHIK LA+SD+  +G R+VFFELNGQLRS+ + D +A K +   PKA K V+G +G+PMPG+V++VKV  G  V KGQ LC++SAMKME  V SP++G ++ VHV   M +EG+DL++EIE
Sbjct:   32 LEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENGVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTNSPINSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPATHLDPQLRSRLTSDSVKLAKQVGYENAGTVEFLVDK-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVSEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIPFLQNVLNNQQFLAGIVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKVSPSPVDPIVPVVPIGPPP-AGFRDILLREGPEGFARAVRNHQGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFNNLFSIENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRIFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLEYYMGLAEELVRAGTHILCIKDMAGLLKPAACTMLVSSLRDRFPDLPLHIHTHDTSGSGVAAMLACAQAGADVVDVAVDSMSGMTSQPSMGALVACTKGTPLDTEVPLERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGIPHGGFPEPFRSKVLKDLPRIEGRPGASLPPLNLKELEKDLIDRHGEEVTPEDVLSAAMYPDVFAQFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDVKVAAGAKVVKGQPLCVLSAMKMETVVTSPMEGTIRKVHVTKDMTLEGDDLILEIE 1178

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BLAST of Pyruvate carboxylase vs. UniProt/SwissProt
Match: sp|Q05920|PYC_MOUSE (Pyruvate carboxylase, mitochondrial OS=Mus musculus OX=10090 GN=Pc PE=1 SV=1)

HSP 1 Score: 1515.36 bits (3922), Expect = 0.000e+0
Identity = 738/1149 (64.23%), Postives = 925/1149 (80.50%), Query Frame = 3

Query:  135 LTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            L  K I+KV+VANRGEIAIRVFRAC E+GIR+VA+YSEQDT QMHR KADE+YLIG+GL PV AYL+I +IIK++K + VDA+HPGYGFLSER+DFA AC +AG++FIGP  +VVRKMGDKVEAR  A+ A V VVPG+  PI +  EA EF   +G PII KAAYGGGGRGMRVV   E L EN+TRA SEALAAFGNG +F+EKFIE+PRHIEVQILGD++GN +HL+ERDCS+QRRHQK+VEIAPA +L   +R ++ SD+VKLAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +QI ++EG+SLP+LGL QE IR  G AIQCR+TTEDPAR FQPD+GR+EVFRSGEGMGIRLD+ASAF GA+ISP+YDSLL+KVIAH  +   A  KM R+L EFRVRGVKTNIPFL NVL N++FL G+VDT FIDE+P LFQ + +QNRAQKLL YLG +MVNGP T +  ++ PS ++P +P  PI      G+RDIL++ GP+ FA+AVR H G L+MDTTFRDAHQSLLATRVRT+D+ +I+P+VA NF  LFS+ENWGGATFDV+MRFL ECPW RL+ LR+LIPNIPFQMLLRGANAVGYTNYPDN+V+KFC++A ++GMD+FRVFD LNYLPN+++GM+A   AGGVVEA+  Y+GD+ DP++TKY+L YY+ LA++LV+ G HIL IKDMAG+LKP A  +L+  LR ++PD+P+H+H+HDT+GAGVA MLA A++G D+VD A+DSMSG+TSQPSMGA+VAC + TPLDT + LE+++ YS YWE AR LY  F+CT TM+SGN+DVY N+IPGGQYTNL FQ+ S+GL  +F+EVK+ Y  AN +LGD+IKVTPSSKIVGDLAQFMVQN +       +A+ELS P+SV+EF QG++G P+GGFPE  RSKV+K+   I GRPG  L   + +  + +L D    +   +D++S A+YP VF +F+ F   FGP+  L TR+FL GP+IAEE  V+LE+GKTLHIK LA+SD+  +G R+VFFELNGQLRS+ + D +A K +   PKA K V+G +G+PMPG+V+++KV  GD V KGQ LC++SAMKME  V SP++G ++ VHV   M +EG+DL++EIE
Sbjct:   32 LEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENGVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDSPISSLHEAHEFSNTFGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPATHLDPQLRSRLTSDSVKLAKQVGYENAGTVEFLVDK-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVSEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIPFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVNVSPSPVDPAVPVVPIGPPP-AGFRDILLREGPEGFARAVRNHQGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFNKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLEYYMGLAEELVRAGTHILCIKDMAGLLKPAACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAVDSMSGMTSQPSMGALVACTKGTPLDTEVPLERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGIPHGGFPEPFRSKVLKDLPRIEGRPGASLPPLNLKELEKDLIDRHGEEVTPEDVLSAAMYPDVFAQFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVAAGDKVAKGQPLCVLSAMKMETVVTSPMEGTIRKVHVTKDMTLEGDDLILEIE 1178

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BLAST of Pyruvate carboxylase vs. TrEMBL
Match: A0A4Z2CX27 (Pyruvate carboxylase OS=Schistosoma japonicum OX=6182 GN=EWB00_006959 PE=4 SV=1)

HSP 1 Score: 1683.31 bits (4358), Expect = 0.000e+0
Identity = 814/1151 (70.72%), Postives = 969/1151 (84.19%), Query Frame = 3

Query:  129 QILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            Q  T K+I+K++VANRGEIAIR+FRAC EM IR+VAIYSEQD MQMHR KADESYLIGK L PVAAYLNI EII+++  HDV+AIHPGYGFLSERS+FA AC +AGI FIGP A VV++MGDKVEARQAA++ANV+VVPGSPGPI + EEAMEF K+YGLP+ILKAAYGGGGRGMRVV++LE L +NF  A SEALAAFGNG MFIEKFIERPRHIEVQILGDK+G  VHL+ERDCSVQRRHQK+VEIAPAPNL  +IR+ +L+DAV+LA  VGYENAGTVEFLYDQ + ++YFIEVNARLQVEHTVTE++TGVDLVRSQI IAEG+SL +L LTQ++I S GYAIQCRITTEDPA+ FQPDSGR+EVF+SGEGMGIRLDSASAFAGAIISPYYDSLL+K+IA A++FRLA  KMLRSL EFR+ G+KTNIPFL NVL++E+FL+G VDT FIDEHP+LF    ++ RAQKLL+Y+G  MVNGP T+LAT L PS I P +P+ P  +  P GWR+IL++ GP  FA+A+R HP  LI DTT RDAHQSLLATRVRT+D+  I+P++A   P LFSLENWGGATFDVSMRFL ECPWERL+ LR L+PNIPFQMLLRGANAVGY NYPDNIVYKFC++AV++G+DIFRVFD LNYLPN+I+GMDAV  AGGV+E S CYSGD+++PT  KYNL YY+ L D+LVK G HILGIKDMAG+LKPN+ R+LI  +R +YP++PIHLH+HDTAGAGVA +LAAAESGVDIVD A+DSMSG+TSQPSMGAVVACLQ+T +DTGL+ + I  YSSYWEQ R LY PFECTTTMRSGNADVY NQIPGGQYTNLQFQS+SLGL DQFE VK+KY+ AN LLGD+IKVTPSSKIVGDLAQFMVQN + A+ ++++A+ELS P SVIEFF G +G PYGGFPE LR+K+++  K  T R G  ++ FDF+    +L + F  DFD+ D++S ALYP VF EF+ FR+ +GPV +L TR+F VGP+IAEE  VDLE GK LHIKTLA+ D+  +G R VFFE+NGQLRS+ I DKEA+K+I   PKA K V+GSVGSPMPGE++ + VKEGD V+KGQ L  +SAMKMEMS+ +P+ G +K VH++  MK+ G+DL+ +IE
Sbjct:   37 QKTTGKQIKKLMVANRGEIAIRIFRACTEMNIRTVAIYSEQDKMQMHRQKADESYLIGKSLPPVAAYLNIPEIIQLALKHDVEAIHPGYGFLSERSEFAQACADAGIIFIGPSAKVVKRMGDKVEARQAAINANVSVVPGSPGPITSSEEAMEFCKQYGLPVILKAAYGGGGRGMRVVRKLEDLKQNFEMASSEALAAFGNGAMFIEKFIERPRHIEVQILGDKYGKVVHLYERDCSVQRRHQKLVEIAPAPNLDPTIRNALLNDAVRLASSVGYENAGTVEFLYDQTSGRYYFIEVNARLQVEHTVTEEITGVDLVRSQIRIAEGRSLDDLNLTQDKIESHGYAIQCRITTEDPAKQFQPDSGRIEVFQSGEGMGIRLDSASAFAGAIISPYYDSLLVKIIARASDFRLASKKMLRSLAEFRIHGIKTNIPFLMNVLKHEQFLSGVVDTNFIDEHPDLFNLPPAKQRAQKLLRYIGNTMVNGPSTLLATKLPPSDIEPTVPQVPYVNHIPRGWRNILLELGPVEFAKAIRAHPRLLITDTTMRDAHQSLLATRVRTFDLLRIAPYLAYQMPQLFSLENWGGATFDVSMRFLHECPWERLQQLRALVPNIPFQMLLRGANAVGYKNYPDNIVYKFCEVAVKNGLDIFRVFDSLNYLPNLIMGMDAVGTAGGVIEGSICYSGDLSNPTLDKYNLNYYMDLTDELVKAGTHILGIKDMAGLLKPNSIRMLISAIRDRYPNMPIHLHTHDTAGAGVACLLAAAESGVDIVDVAVDSMSGMTSQPSMGAVVACLQHTDIDTGLSSKDISVYSSYWEQTRSLYAPFECTTTMRSGNADVYENQIPGGQYTNLQFQSYSLGLGDQFENVKRKYSEANQLLGDIIKVTPSSKIVGDLAQFMVQNNLTAQQVLDRAEELSFPTSVIEFFSGAIGIPYGGFPEPLRTKIMRGQKIQTERAGTRMEPFDFDKLAEQLKEKFKRDFDEHDLLSAALYPKVFDEFEEFRKIYGPVDRLPTRMFFVGPKIAEEFPVDLETGKMLHIKTLAVGDLTKTGERAVFFEMNGQLRSILIRDKEATKSISFHPKALKGVKGSVGSPMPGELVTINVKEGDIVEKGQKLATLSAMKMEMSITAPIPGCIKKVHISSGMKVSGDDLLFDIE 1187

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BLAST of Pyruvate carboxylase vs. TrEMBL
Match: A0A3Q0KND4 (Pyruvate carboxylase OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 1677.53 bits (4343), Expect = 0.000e+0
Identity = 810/1158 (69.95%), Postives = 970/1158 (83.77%), Query Frame = 3

Query:  120 KSDQILTQ----KKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            K+D   TQ    +KI+K++VANRGEIAIR+FRAC EM IR+VAIYSEQD MQMHR KADESYLIGK L PVAAYLNI EII+++  HDV+AIHPGYGFLSERS+FA AC +AGI FIGPPA+VV++MGDKVEARQAA++ANV+VVPGSPGPI + EEAMEF K+YGLP+ILKAAYGGGGRGMRVV++LE + +NF  A SEALAAFGNG MFIEKFIERPRHIEVQILGDK+GN VHL+ERDCSVQRRHQK+VEIAPAP+L  +IR  +LSDAV+LA  V YENAGTVEFLYDQ T ++YFIEVNARLQVEHTVTE++TGVDLVRSQI +AEG+SL +L L+Q++I   G+AIQCRITTEDPA+ FQPDSGR+EVF+SGEGMGIR+DSASAFAGAIISPYYDSLL+K+IA A++FRLA  KMLRSL EFR+ GVKTNIPFL NV+++E+FL+G VDT FIDEHP+LF    ++ RAQKLL+Y+G +M+NGP T+LAT L PS I PK+P     +  P GWR++L++ GP  F++A+R HP  LI DTT RDAHQSLLATRVRT+D+  I P++A   P LFS+ENWGGATFDVSMRFL ECPWERLE LR +IPNIPFQMLLRGANAVGY NYPDNI+YKFC++AV++G+DIFR+FD LNYLPN+I+GMDAV  AGGVVE S CYSGD+ +P   KYNL YY+ L D LVK G HILGIKDMAG+LKPNAARIL+  +R +YPDIPIHLH+HDTAGAGVA +LAAAESGVDIVD A+DSMSGLTSQPSMGA+VACL++T  DTGL+ E + +YS+YWEQ R LY PFECTTTMRSGNADVY NQIPGGQYTNLQFQS+SLGL DQFE VK+KY  AN LLGD+IKVTPSSKIVGDLAQFMVQN + A+ ++++A+ELS P SVIEFF G +G PYGGFPE LR+K+++  K  T R G  ++ FDF+    +L + F  DFD++D++S ALYP VF EF+ FR+ +GPV +L TR+F VGP+IAEE  VDLE GK LHIKTLA+ ++  +G REVFFE+NGQLRS+ I DKEA+K+I   PKA K V+GS+GSPMPGE++ + VKEGD V+KGQ L  +SAMKMEMS+ SP+ G VK +HV+  MK+ G+DL+ +IE
Sbjct:   30 KTDTGATQNTSGRKIKKLMVANRGEIAIRIFRACTEMNIRTVAIYSEQDKMQMHRQKADESYLIGKSLPPVAAYLNIPEIIQLALRHDVEAIHPGYGFLSERSEFAQACADAGIIFIGPPANVVKRMGDKVEARQAAINANVSVVPGSPGPITSSEEAMEFCKQYGLPVILKAAYGGGGRGMRVVRKLEDIKQNFELASSEALAAFGNGAMFIEKFIERPRHIEVQILGDKYGNVVHLYERDCSVQRRHQKLVEIAPAPSLDPTIRKSLLSDAVRLASSVDYENAGTVEFLYDQTTGRYYFIEVNARLQVEHTVTEEITGVDLVRSQIRLAEGRSLSDLNLSQDKIEPHGFAIQCRITTEDPAKQFQPDSGRIEVFQSGEGMGIRVDSASAFAGAIISPYYDSLLVKIIARASDFRLAAKKMLRSLAEFRIHGVKTNIPFLMNVIKHEQFLSGIVDTNFIDEHPDLFDLPPAKQRAQKLLRYIGNIMINGPSTMLATQLPPSDIEPKVPTISYANHIPRGWRNMLLEKGPVEFSKAIRSHPHLLITDTTMRDAHQSLLATRVRTFDLLRIGPYLAYQMPQLFSIENWGGATFDVSMRFLHECPWERLEQLRNIIPNIPFQMLLRGANAVGYKNYPDNIIYKFCEVAVKNGIDIFRIFDSLNYLPNLIMGMDAVGTAGGVVEGSICYSGDLANPKLDKYNLQYYMDLTDQLVKAGTHILGIKDMAGLLKPNAARILLSAIRDRYPDIPIHLHTHDTAGAGVACLLAAAESGVDIVDVAVDSMSGLTSQPSMGALVACLKHTDNDTGLSSEDVSTYSAYWEQTRSLYAPFECTTTMRSGNADVYENQIPGGQYTNLQFQSYSLGLGDQFENVKRKYTEANQLLGDIIKVTPSSKIVGDLAQFMVQNGLTAQQVLDRAEELSFPSSVIEFFSGEIGFPYGGFPEPLRTKIMRGQKAKTERVGSHMEPFDFDKLAKQLKEKFKRDFDERDLLSAALYPKVFNEFEEFRKIYGPVDRLPTRMFFVGPKIAEEFPVDLETGKMLHIKTLAVGELTKAGEREVFFEMNGQLRSILISDKEATKSISFHPKALKGVKGSIGSPMPGELVTINVKEGDVVEKGQKLATLSAMKMEMSITSPIAGCVKKIHVSSGMKVSGDDLLFDIE 1187

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BLAST of Pyruvate carboxylase vs. TrEMBL
Match: A0A094ZHZ7 (Pyruvate carboxylase OS=Schistosoma haematobium OX=6185 GN=MS3_02353 PE=4 SV=1)

HSP 1 Score: 1666.74 bits (4315), Expect = 0.000e+0
Identity = 805/1158 (69.52%), Postives = 968/1158 (83.59%), Query Frame = 3

Query:  120 KSDQILTQ----KKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            K+D   TQ    +KI+K++VANRGEIAIR+FRAC EM IR+VAIYSEQD MQMHR KADESYLIGK L PVAAYLNI EII+++  H+V+AIHPGYGFLSERS+FA AC +AGI FIGPPA VV++MGDKVEARQAA++ANV+VVPGSPGPI + EEAMEF K+YGLP+ILKAAYGGGGRGMRVV+ LE + +NF  A SEALAAFGNG MFIEKFIERPRHIEVQILGDK+GN VHL+ERDCSVQRRHQK+VEIAPAP+L  ++R  +L+DAV+LA  V YENAGTVEFLYDQ T  +YFIEVNARLQVEHTVTE++TGVDLVRSQI +AEG+SL +L L Q++I   G+AIQCRITTEDPA+ FQPDSGR+EVF+SGEGMGIR+DSASAFAGAIISPYYDSLL+K+IA A+NFRLA  KMLRSL EFR+ GVKTNIPFL NV+++E+FL+G VDT FIDEHP+LF    ++ RAQKLL+Y+G  MVNGP T+LAT L PS I PK+P+    +  P GWR+IL++ GP  F++A+R HP  LI DTT RDAHQSLLATRVRT+D+  I P++A   P LFS+ENWGGATFDVSMRFL ECPW RLE LR +IPNIPFQMLLRGANAVGY NYPDNI+YKFC++AV++G+DIFR+FD LNYLPN+++GMDAV  AGGVVE S CYSGD+++P   KYNL YY+ L D LVK G HILGIKDMAG+LKPNAARIL+  +R +YPDIPIHLH+HDTAGAGVA +LAAAESGVDIVD A+DSMSGLTSQPSMGA+VACL++T +DTGL+ E + +YS+YWEQ R LY PFECTTTMRSGNADVY NQIPGGQYTNLQFQS+SLGL DQFE VK+KY  AN LLGD+IKVTPSSKIVGDLAQFMVQN + A+ ++++A+ELS P SVIEFF G +G PYGGFPE LR+K+++  K  T R G  ++ FDF+    +L + F  DFD++D++S ALYP VF EF+ FR+ +GPV +L TR+F VGP+IAEE  VDLE GK LHIKTLA+ ++  +G REVFFE+NGQLRS+ I DKEA+K+I   PKA K V+GSVGSPMPGE++ + VK+GD V+KGQ L  +SAMKMEMS+ +P+ G +K ++V+  MK+ G+DL+++IE
Sbjct:   30 KTDTGATQNTSGRKIKKLMVANRGEIAIRIFRACTEMNIRTVAIYSEQDKMQMHRQKADESYLIGKSLPPVAAYLNIPEIIQLALRHNVEAIHPGYGFLSERSEFAQACTDAGIIFIGPPAKVVKRMGDKVEARQAAINANVSVVPGSPGPITSSEEAMEFCKQYGLPVILKAAYGGGGRGMRVVRRLEDIKQNFELASSEALAAFGNGAMFIEKFIERPRHIEVQILGDKYGNVVHLYERDCSVQRRHQKLVEIAPAPSLDPTVRKSLLNDAVRLASSVDYENAGTVEFLYDQTTGHYYFIEVNARLQVEHTVTEEITGVDLVRSQIRLAEGRSLSDLNLCQDKIEPHGFAIQCRITTEDPAKQFQPDSGRIEVFQSGEGMGIRVDSASAFAGAIISPYYDSLLVKIIARASNFRLAAKKMLRSLAEFRIHGVKTNIPFLMNVIKHEQFLSGIVDTNFIDEHPDLFDLPPAKQRAQKLLRYIGNTMVNGPSTLLATKLPPSDIEPKVPKISYANSIPRGWRNILLEKGPVEFSKAIRSHPHLLITDTTMRDAHQSLLATRVRTFDLLRIGPYLAYQMPQLFSIENWGGATFDVSMRFLHECPWGRLEQLRNVIPNIPFQMLLRGANAVGYKNYPDNIIYKFCEVAVKNGIDIFRIFDSLNYLPNLLMGMDAVGTAGGVVEGSICYSGDLSNPKLDKYNLKYYMDLTDQLVKAGTHILGIKDMAGLLKPNAARILLSAIRDRYPDIPIHLHTHDTAGAGVACLLAAAESGVDIVDVAVDSMSGLTSQPSMGALVACLKHTDIDTGLSSEDVSTYSAYWEQTRSLYAPFECTTTMRSGNADVYENQIPGGQYTNLQFQSYSLGLGDQFENVKRKYTEANQLLGDIIKVTPSSKIVGDLAQFMVQNGLSAQQVLDRAEELSFPSSVIEFFSGEIGFPYGGFPEPLRTKIMRGQKAKTERVGSHMEPFDFDKLAKQLKEKFKRDFDERDLLSAALYPKVFDEFEEFRKIYGPVDRLPTRMFFVGPKIAEEFPVDLETGKMLHIKTLAVGELTKAGEREVFFEMNGQLRSILISDKEATKSISFHPKALKGVKGSVGSPMPGELVTINVKDGDVVEKGQKLATLSAMKMEMSITAPISGCIKKIYVSSGMKVSGDDLLLDIE 1187

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BLAST of Pyruvate carboxylase vs. TrEMBL
Match: K1QHI5 (Pyruvate carboxylase, mitochondrial OS=Crassostrea gigas OX=29159 GN=CGI_10017251 PE=4 SV=1)

HSP 1 Score: 1655.57 bits (4286), Expect = 0.000e+0
Identity = 805/1200 (67.08%), Postives = 976/1200 (81.33%), Query Frame = 3

Query:   30 KMSAMFQAIKLKCKPNFHSKFLFHN----SGINYKSDQILTQ----KKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIK--------DMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            ++S + Q+ +++  PN       H      G+   S Q  +Q    +KI+K++VANRGEIAIRVFRAC EM I++VAIYSEQD M MHR KADESYLIGKGL PVAAYLNI EII+++K + VDAIHPGYGFLSER DFA    +AGI+FIGP  +VVRKMGDKVEARQAA+ A V VVPGS GP+ + EEA  F ++YGLP+I KAAYGGGGRGMR+V+ +E + ENF RA SEA AAFGNG +F+EKFIERPRHIEVQILGD+ GN VHL+ERDCSVQRRHQK+VEIAPAP L + IRDKM +DAVKLA+FVGYENAGTVEFL D  + ++YFIEVNARLQVEHTVTE+VTG+DLV+SQI IAEGK LPE+GL+Q+EI   G AIQCR+TTEDPAR FQPD+GR+EVFRSGEGMGIRLDSA  FAGAIISPYYDSLL+KVIA A +   A AKMLR+L+EFR+RGVKTNIPFL NVL++++FL+G VDTYFIDE+P LF+F  +QNRAQKLL YL  +MVNGP T LATDL+PS + P +P+ P     PTGWRD+LVK GP+AFA+ VR+H G L+MDTTFRDAHQSLLATRVRTYD+  ISPFV Q F NL+SLENWGGATFDV+MRFL ECPWERLE +RKL+PN+PFQMLLRGANAVGYTNYPDN+VYKFCD+AV+SGMDIFR+FD LNYLPNI+VGMDAV KAGGV+EA+  Y+GD++DP+KTKYNL YY+ LA +LVK G HIL IK        DMAGVLKP AA +L+G LR K+PDIPIH+H+HDTA AGVA+MLAAA++G D+VD A+DSMSGLTSQPSMGAVVA L+ T LDTG++L  +  YS+YWEQ R LY PFEC  T++SGN+DVY NQIPGGQYTNLQFQ+FSLGLADQFEEVK+ YA AN LLGD+ KVTPSSK+VGD+AQFMVQNK+  + + ++A+ELS P SV+E+FQG++G P GG+PE LR+K++K  + +  RPG+ L   DF+  K +L +   HD  ++ ++S ALYP V  +F  F +++GPV  L T+IF VGP++A+E+ V +EKGKTL IKTLA  D+  +G REVFFELNGQLRSV+I D+EASK +   PKA K VRGSVG+PMPGEV++VKVKEGD V+KGQ + ++SAMKMEM V +P  G V+ + V  KMK+EG+DL+++IE
Sbjct:  175 RLSTLCQSARVQL-PNVARGHNHHGYKLPPGVACCSTQAKSQSKPEEKIKKLMVANRGEIAIRVFRACTEMNIQTVAIYSEQDMMHMHRQKADESYLIGKGLPPVAAYLNIPEIIQVAKENGVDAIHPGYGFLSERDDFAQQVLDAGIRFIGPSPEVVRKMGDKVEARQAAIAAGVQVVPGSDGPVASIEEARHFCEQYGLPVIFKAAYGGGGRGMRIVRSMEEVDENFRRATSEAEAAFGNGALFLEKFIERPRHIEVQILGDRGGNVVHLYERDCSVQRRHQKVVEIAPAPKLPLDIRDKMTADAVKLARFVGYENAGTVEFLLDP-SGQYYFIEVNARLQVEHTVTEEVTGIDLVQSQIQIAEGKLLPEMGLSQDEIELHGCAIQCRMTTEDPARGFQPDTGRIEVFRSGEGMGIRLDSALGFAGAIISPYYDSLLVKVIAKARDHPAAAAKMLRTLKEFRIRGVKTNIPFLLNVLQHDQFLSGVVDTYFIDENPQLFKFYPTQNRAQKLLYYLAQVMVNGPQTPLATDLQPSDVVPSVPQLPFAPTPPTGWRDVLVKEGPEAFAKKVREHKGLLLMDTTFRDAHQSLLATRVRTYDLKRISPFVTQRFNNLYSLENWGGATFDVAMRFLHECPWERLEEMRKLVPNVPFQMLLRGANAVGYTNYPDNVVYKFCDMAVKSGMDIFRIFDSLNYLPNIVVGMDAVGKAGGVIEAAISYTGDVSDPSKTKYNLEYYVNLATELVKAGTHILSIKVSSYMNAQDMAGVLKPRAATMLVGALREKFPDIPIHVHTHDTACAGVASMLAAAQAGADVVDVAVDSMSGLTSQPSMGAVVAALEGTDLDTGISLSDVTDYSAYWEQTRNLYAPFECCKTLKSGNSDVYINQIPGGQYTNLQFQAFSLGLADQFEEVKKMYAEANQLLGDIPKVTPSSKVVGDMAQFMVQNKLTKEMVEDRAEELSFPVSVMEYFQGYLGVPPGGYPEPLRTKILKGQQGLDSRPGESLPPVDFDKLKADLVEKHGHDVKEQHVISAALYPKVTDDFLEFHDKYGPVDALDTKIFFVGPKVAQEMEVKIEKGKTLSIKTLACGDLNKNGEREVFFELNGQLRSVKIKDEEASKELHFHPKALKGVRGSVGAPMPGEVIDVKVKEGDKVEKGQPVLVLSAMKMEMVVTAPASGTVRSIAVEKKMKLEGDDLLMDIE 1372

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BLAST of Pyruvate carboxylase vs. TrEMBL
Match: A0A0P5LPJ2 (Pyruvate carboxylase, mitochondrial OS=Daphnia magna OX=35525 PE=4 SV=1)

HSP 1 Score: 1635.54 bits (4234), Expect = 0.000e+0
Identity = 795/1162 (68.42%), Postives = 969/1162 (83.39%), Query Frame = 3

Query:  105 SGINYKSDQI--LTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALS-DIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            S  NY  ++   +  K IR VLVANRGEIAIRVFRAC+E+GIRSVAIYSEQD MQ+HR KADESYL+GKGL PVAAYL+I EII+++K + VDAIHPGYGFLSER+DFA AC ++GI+FIGP   VV +MGDKV ARQAA++ANV +VPG+PGP+ T EEA+ F ++YGLP+I KAAYGGGGRGMRVV+++E + E F RA SEALAAFGNG MFIEKF+ERPRHIEVQILGD+ GN VHL+ERDCSVQRRHQK+VEIAPAPNL   +RD+M +DAV+L   VGYENAGTVEFL D+   +HYFIEVNARLQVEHTVTE+VTG+DLV+ Q+ IAEG +LPELGL Q +I+  G AIQCR+TTEDPA++FQPD+GR+EVFRSGEGMGIRLDSASAFAGAIISPYYDSLL+KVIAHA N   + AKM+R+LREFRVRGVKTNIPFL NVLEN++FL G++DTYFIDEHP LFQF  SQNRAQKLL Y+G ++VNGP+T L TDLKP+ + P +P+   +    TG+RDIL + GP+AFA+AVR H G L+MDTTFRDAHQSLLATRVRT+D+ +ISPFVAQNF +L+SLENWGGATFDV+MRFL ECPWERLE +R+++PNIPFQMLLRGANAVGYT+YPDN+VYKFC+LAVQ+GMDIFRVFD LNYLPN+I+G+DAV KAGGVVEA+  YSGD++DP++TKY LPYYL LAD+LVK G H+L IKDMAG+LKP AA +LI  +R ++PDIPIH+H+HDT+GAGVA+MLAAA +G D+VD A+DSMSG+TSQPSMGAVVA LQ + LDTGL+LE +  YS+YWEQ R LY PFEC  TM+SGNADVY N+IPGGQYTNLQFQ++SLGL +QFE++K+ Y  AN LLGD+IKVTPSSK VGDLAQFMVQNK+  + ++++A+ELS PKSV+EF QG++G PYGGFPE LR++V+K  K + GRPG  +   D +  K +L +   +   D D+MS A+YP+V KE+  FR ++GPV K  TRIFL GP++ EE  V +EKGKTLHIKTLA++ D+  +G REVFFELNGQLRSV I DK A+K + + PKA+K V+GSVG+PMPG V++++VK GD V+KGQ L ++SAMKMEM V SP  G VK V +   MK+EG+DL++ IE
Sbjct:   81 SQANYSPNKCKDVEYKPIRSVLVANRGEIAIRVFRACSELGIRSVAIYSEQDKMQVHRQKADESYLVGKGLPPVAAYLSIPEIIRVAKENRVDAIHPGYGFLSERADFAQACVDSGIRFIGPSPRVVHQMGDKVAARQAAIEANVPIVPGTPGPVTTTEEAVNFCREYGLPVIFKAAYGGGGRGMRVVRKMEEVEELFRRATSEALAAFGNGAMFIEKFVERPRHIEVQILGDRAGNVVHLYERDCSVQRRHQKVVEIAPAPNLNQEVRDRMTTDAVRLCNHVGYENAGTVEFLVDE-AGRHYFIEVNARLQVEHTVTEEVTGIDLVQHQVKIAEGLTLPELGLDQSQIKIQGSAIQCRMTTEDPAKNFQPDTGRIEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLVKVIAHAGNLPASAAKMVRALREFRVRGVKTNIPFLLNVLENQKFLTGTLDTYFIDEHPELFQFVPSQNRAQKLLNYVGDVLVNGPLTPLGTDLKPADVVPLVPQVDSSQRL-TGFRDILTEQGPEAFAKAVRNHKGLLLMDTTFRDAHQSLLATRVRTHDLLKISPFVAQNFSSLYSLENWGGATFDVAMRFLHECPWERLEEMRRIMPNIPFQMLLRGANAVGYTSYPDNVVYKFCELAVQTGMDIFRVFDSLNYLPNMILGIDAVGKAGGVVEAAISYSGDVSDPSRTKYTLPYYLDLADELVKAGTHVLCIKDMAGLLKPRAATMLIDGIRQRHPDIPIHVHTHDTSGAGVASMLAAAHAGADVVDVAVDSMSGMTSQPSMGAVVASLQGSELDTGLSLESVSDYSAYWEQTRTLYAPFECCVTMKSGNADVYLNEIPGGQYTNLQFQAYSLGLGNQFEDIKKAYREANLLLGDIIKVTPSSKTVGDLAQFMVQNKLSGQDVLDRAEELSFPKSVVEFMQGYLGIPYGGFPEPLRTRVLKGMKKVEGRPGATMAPLDLDKLKSDLIEAHGNQIRDVDVMSAAMYPSVCKEYLEFRSKYGPVDKFATRIFLTGPKVGEEFEVTIEKGKTLHIKTLAMAEDLTRTGDREVFFELNGQLRSVFIRDKTAAKELHIHPKAEKGVKGSVGAPMPGTVIDLRVKAGDKVEKGQPLVVLSAMKMEMVVQSPCTGTVKSVAITKDMKLEGDDLLLNIE 1240

[Close]

BLAST of Pyruvate carboxylase vs. Ensembl Cavefish
Match: pcxb (pyruvate carboxylase b [Source:ZFIN;Acc:ZDB-GENE-000831-1])

HSP 1 Score: 1508.43 bits (3904), Expect = 0.000e+0
Identity = 735/1105 (66.52%), Postives = 897/1105 (81.18%), Query Frame = 3

Query:  264 MHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEI 3578
            MHR KADE+YLIGKGL PVAAYL+I +IIK++K ++VDAIHPGYGFLSERSDFA AC +AG++F+GP  DVVRKMGDKVEAR  A+ A V VVPG+  PI + +EA EF K YG PII KAAYGGGGRGMRVV+E E L EN+ RA SEALAAFGNG +F+EKFIE+PRHIEVQILGDK+GN +HL+ERDCS+QRRHQK+VEIAPA  L   +RD++ SD+V LAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +Q+ + EG+SLPELGL Q++IR  G AIQCR+TTEDPAR FQPD+GRLEVFRS EGMGIRLDSASAF GA+ISP+YDSLL+KVI+   +   A +KMLR+L EFR+RGVKTNIPFL NVL N +FL+ +VDT FIDE+ +LF  K++QNRAQKLL YLG +MVNGP T +    KPS  +P IP  P+  E P G+R++L++ GP+ FA+AVR+H G L+MDTTFRDAHQSLLATRVRT+D+ +I+P+V+ NF NLFSLENWGGATFDV+MRFL ECPW RL+ LR L+PN+PFQMLLRGANAVGYTNYPDN V+KFC++A ++GMDIFRVFD LNYLPN+++GM+A   AGGVVEA+  Y+GD++DP + KY+L YY++LAD+LVK G HIL IKDMAG+LKP ++RILI  LR ++PD+PIH+H+HDTAGAGVA MLA AE+G DIVD A+DSM+G+TSQPSMGA+VAC + T LDTG++LEK++ YS YWE AR LY PF+CT TM+SGNADVY N+IPGGQYTNL FQ+ S+GL ++F+EVK+ YA AN LLGD+IKVTPSSKIVGDLAQFMVQN +    + E+ADELS P SV+EF QGHVG P+GGFPE  RSKV+K+   + GRPG  L A DF+  + +L      +   +D+MS A+YP VFKEF+ FR  FGPV +L TR+FL GP IAEE  V+LE+GKTLHIK LAL D+  +G REVFFELNGQLRSV + D  A K +   PKA K VRG VG+PMPG+V+EVKVK+G  V+KGQ LC++SAMKME  VNSP+ G V  V+V     +EG+DL++EI
Sbjct:    1 MHRQKADEAYLIGKGLPPVAAYLHIPDIIKVAKENNVDAIHPGYGFLSERSDFAQACEDAGVRFVGPSPDVVRKMGDKVEARALAIQAGVPVVPGTDAPITSQQEAHEFAKTYGFPIIFKAAYGGGGRGMRVVREYEELEENYQRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDKYGNVIHLYERDCSIQRRHQKVVEIAPAAQLDPHLRDRLTSDSVTLAKQVGYENAGTVEFLVDK-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQLRVCEGRSLPELGLKQDKIRINGCAIQCRVTTEDPARGFQPDTGRLEVFRSAEGMGIRLDSASAFQGAVISPHYDSLLVKVISSGKDLPTAASKMLRALAEFRIRGVKTNIPFLQNVLSNNQFLHSTVDTQFIDENQDLFNLKRTQNRAQKLLHYLGHVMVNGPTTPIPVKAKPSSTDPVIPPVPLG-EPPAGFREVLLREGPEGFAKAVRQHQGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVSHNFNNLFSLENWGGATFDVAMRFLYECPWRRLQELRALLPNVPFQMLLRGANAVGYTNYPDNSVFKFCEVAKENGMDIFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVSDPMRQKYSLDYYVQLADELVKAGTHILSIKDMAGLLKPESSRILITALRDRFPDMPIHVHTHDTAGAGVAAMLACAEAGADIVDVAVDSMAGMTSQPSMGAIVACTKGTKLDTGISLEKVFDYSEYWEVARGLYAPFDCTATMKSGNADVYENEIPGGQYTNLHFQAHSMGLGNKFKEVKKAYAEANKLLGDLIKVTPSSKIVGDLAQFMVQNSLSRAEVEERADELSFPLSVVEFLQGHVGIPHGGFPEPFRSKVLKSLPRVEGRPGATLPAIDFKKLEADLKAEHGSEITPEDVMSAAMYPKVFKEFKEFRRSFGPVDRLSTRLFLDGPNIAEEFEVELERGKTLHIKALALGDLNKAGQREVFFELNGQLRSVLVKDTVAMKEMHFHPKALKDVRGQVGAPMPGKVVEVKVKQGQKVEKGQPLCVLSAMKMETVVNSPLSGTVAKVYVKTDTSLEGDDLILEI 1103

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BLAST of Pyruvate carboxylase vs. Ensembl Cavefish
Match: pcxb (pyruvate carboxylase b [Source:ZFIN;Acc:ZDB-GENE-000831-1])

HSP 1 Score: 1325.84 bits (3430), Expect = 0.000e+0
Identity = 645/944 (68.33%), Postives = 782/944 (82.84%), Query Frame = 3

Query:  117 YKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKV 2948
            + S Q L  + I+KV+VANR        RAC E+GIR+VA+YSEQDT QMHR KADE+YLIGKGL PVAAYL+I +IIK++K ++VDAIHPGYGFLSERSDFA AC +AG++F+GP  DVVRKMGDKVEAR  A+ A V VVPG+  PI + +EA EF K YG PII KAAYGGGGRGMRVV+E E L EN+ RA SEALAAFGNG +F+EKFIE+PRHIEVQILGDK+GN +HL+ERDCS+QRRHQK+VEIAPA  L   +RD++ SD+V LAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T VDLV +Q+ + EG+SLPELGL Q++IR  G AIQCR+TTEDPAR FQPD+GRLEVFRS EGMGIRLDSASAF GA+ISP+YDSLL+KVI+   +   A +KMLR+L EFR+RGVKTNIPFL NVL N +FL+ +VDT FIDE+ +LF  K++QNRAQKLL YLG +MVNGP T +    KPS  +P IP  P+  E P G+R++L++ GP+ FA+AVR+H G L+MDTTFRDAHQSLLATRVRT+D+ +I+P+V+ NF NLFSLENWGGATFDV+MRFL ECPW RL+ LR L+PN+PFQMLLRGANAVGYTNYPDN V+KFC++A ++GMDIFRVFD LNYLPN+++GM+A   AGGVVEA+  Y+GD++DP + KY+L YY++LAD+LVK G HIL IKDMAG+LKP ++RILI  LR ++PD+PIH+H+HDTAGAGVA MLA AE+G DIVD A+DSM+G+TSQPSMGA+VAC + T LDTG++LEK++ YS YWE AR LY PF+CT TM+SGNADVY N+IPGGQYTNL FQ+ S+GL ++F+EVK+ YA AN LLGD+IKVTPSSKIVGDLAQFMVQN +    + E+ADELS P SV+EF QGHVG P+GGFPE  RSKV
Sbjct:   28 HTSPQTLEYRPIKKVMVANRD--CNPCVRACTELGIRTVAVYSEQDTGQMHRQKADEAYLIGKGLPPVAAYLHIPDIIKVAKENNVDAIHPGYGFLSERSDFAQACEDAGVRFVGPSPDVVRKMGDKVEARALAIQAGVPVVPGTDAPITSQQEAHEFAKTYGFPIIFKAAYGGGGRGMRVVREYEELEENYQRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDKYGNVIHLYERDCSIQRRHQKVVEIAPAAQLDPHLRDRLTSDSVTLAKQVGYENAGTVEFLVDK-HGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQLRVCEGRSLPELGLKQDKIRINGCAIQCRVTTEDPARGFQPDTGRLEVFRSAEGMGIRLDSASAFQGAVISPHYDSLLVKVISSGKDLPTAASKMLRALAEFRIRGVKTNIPFLQNVLSNNQFLHSTVDTQFIDENQDLFNLKRTQNRAQKLLHYLGHVMVNGPTTPIPVKAKPSSTDPVIPPVPLG-EPPAGFREVLLREGPEGFAKAVRQHQGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVSHNFNNLFSLENWGGATFDVAMRFLYECPWRRLQELRALLPNVPFQMLLRGANAVGYTNYPDNSVFKFCEVAKENGMDIFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVSDPMRQKYSLDYYVQLADELVKAGTHILSIKDMAGLLKPESSRILITALRDRFPDMPIHVHTHDTAGAGVAAMLACAEAGADIVDVAVDSMAGMTSQPSMGAIVACTKGTKLDTGISLEKVFDYSEYWEVARGLYAPFDCTATMKSGNADVYENEIPGGQYTNLHFQAHSMGLGNKFKEVKKAYAEANKLLGDLIKVTPSSKIVGDLAQFMVQNSLSRAEVEERADELSFPLSVVEFLQGHVGIPHGGFPEPFRSKV 967

HSP 2 Score: 158.688 bits (400), Expect = 8.467e-39
Identity = 78/128 (60.94%), Postives = 97/128 (75.78%), Query Frame = 3

Query: 3195 VDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEI 3578
            V+LE+GKTLHIK LAL D+  +G REVFFELNGQLRSV + D  A K +   PKA K VRG VG+PMPG+V+EVKVK+G  V+KGQ LC++SAMKME  VNSP+ G V  V+V     +EG+DL++EI
Sbjct:  967 VELERGKTLHIKALALGDLNKAGQREVFFELNGQLRSVLVKDTVAMKEMHFHPKALKDVRGQVGAPMPGKVVEVKVKQGQKVEKGQPLCVLSAMKMETVVNSPLSGTVAKVYVKTDTSLEGDDLILEI 1094

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BLAST of Pyruvate carboxylase vs. Ensembl Cavefish
Match: mccc1 (methylcrotonoyl-CoA carboxylase 1 [Source:NCBI gene;Acc:103043051])

HSP 1 Score: 370.163 bits (949), Expect = 6.683e-113
Identity = 190/450 (42.22%), Postives = 273/450 (60.67%), Query Frame = 3

Query:  147 KIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEH 1496
            +I KVL+ANRGEIA RV R   +MG+RSVA+YS+ D   MH   ADE+Y IG   Q   +YL + ++++++K     A+HPGYGFLSE ++FA  C + GI FIGPP+  +R MG K  ++     A V ++ G  G  Q+ ++      + G P+++KA  GGGG+GMR+        E    A+ EA  +F +  M +EKF+E PRH+EVQ+ GD+ GNAV+LFERDCSVQRRHQKI+E AP P ++  +R K+   AV+ AK V Y  AGTVEF+ D      YF+E+N RLQVEH V+E +TG DLV  Q+ +A G+ +P   L+QE+I   G++ + RI  EDP  DF P +G L+   + +             G  +S +YD ++ K++    +   A  K+   LR++ + G+ TNI FL N+  +  F  G+V T FI +H
Sbjct:   34 RIEKVLIANRGEIACRVMRTAKKMGVRSVAVYSDADRHSMHVAMADEAYHIGAA-QSQQSYLCMEKVLEVAKKSSAQAVHPGYGFLSENTEFAELCKQEGIIFIGPPSSAIRDMGIKSTSKHIMSAAGVPIIEGYHGEDQSDKKLQAEAARIGYPVMIKAVRGGGGKGMRIAHSEAEFHEQLESARREARKSFNDDVMLVEKFVENPRHVEVQVFGDQHGNAVYLFERDCSVQRRHQKIIEEAPGPGISPEVRRKLGEAAVRAAKAVNYVGAGTVEFIMDS-QHNFYFMEMNTRLQVEHPVSEMITGTDLVEWQLRVAAGEKIP---LSQEDIVLRGHSFEARIYAEDPNNDFMPGAGHLQHLSNPQADEHTRIETGVRDGDEVSAHYDPMIAKLVVWGEDRPAALKKLRYCLRQYNIVGLNTNIDFLLNLSGHPEFEAGNVHTSFIPQH 478

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BLAST of Pyruvate carboxylase vs. Ensembl Cavefish
Match: ENSAMXT00000052136.1 (pep primary_assembly:Astyanax_mexicanus-2.0:14:18923125:18932967:-1 gene:ENSAMXG00000038620.1 transcript:ENSAMXT00000052136.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 351.673 bits (901), Expect = 1.620e-111
Identity = 177/297 (59.60%), Postives = 218/297 (73.40%), Query Frame = 3

Query: 2688 LGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEI 3578
            +GL ++F+EVK+ Y  AN LLGD+IKVTPSSKIVGDLAQFMVQN +    + E+ADELS P SV+EF QGHVG P+GGFPE  RSKV+K+   I GRPG  L   DF+A + +L D    D   +D+MS A+YP VF+EF+ F   FGPV  L TR+FL GP+IAEE  V+LE+GKTLHIK LAL D+  +G REVFFELNGQLRSV + D  A K +   PKA K VRG VG+PMPG+V+EVKVKEG  V+KGQ LC++SAMKME  VNSP+ G V  V+V     +EG+DL++EI
Sbjct:    1 MGLGNKFKEVKKAYVEANKLLGDLIKVTPSSKIVGDLAQFMVQNSLTRAEVEERADELSFPLSVVEFLQGHVGIPHGGFPEPFRSKVLKSLPRIEGRPGASLPPMDFQALEKQLRDTHGDDITPEDVMSAAMYPKVFQEFKEFTTAFGPVDCLNTRLFLDGPKIAEEFEVELERGKTLHIKALALGDLNKAGQREVFFELNGQLRSVLVKDTVAMKEMHFHPKALKDVRGQVGAPMPGKVVEVKVKEGQKVEKGQPLCVLSAMKMETVVNSPLSGTVAKVYVNADSSLEGDDLILEI 297

[Close]

BLAST of Pyruvate carboxylase vs. Ensembl Cavefish
Match: pcca (propionyl-CoA carboxylase subunit alpha [Source:ZFIN;Acc:ZDB-GENE-040718-246])

HSP 1 Score: 343.584 bits (880), Expect = 2.670e-103
Identity = 193/461 (41.87%), Postives = 286/461 (62.04%), Query Frame = 3

Query:  141 QKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVA-AYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQ-PDSGRLEVFRSGEGM-GIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDE-HPNLFQ 1511
            +K   K+L+ANRGEIA RV + C +MGI++VA++S+ D+  +H   ADE++ +G    P + +YLN+  I++  +     A+HPGYGFLSE  +FA      G+ FIGP    ++ MGDK+E++  A  A V  +PG  G ++  EEA++   + G P+++KA+ GGGG+GMR+    E   E F  +  EA ++FG+  + IEK+I+ PRHIE+Q+L DK GNA+ L ER+CS+QRR+QK+VE AP+  L    R  M   AV LAK V Y +AGTVEFL D      YF+E+N RLQVEH +TE +TG+DLV+  I +A+G  L      QE+I   G+AI+ R+  EDP + F  P  GRL  +     + G+R+DS     G+ IS YYD ++ K++ + +    A  KM  +L  + +RGV  NIP L  ++ + RF++G + T F+ E +P  F+
Sbjct:   43 EKTFDKILIANRGEIACRVIKTCKKMGIKTVAVHSDVDSSAVHVKMADEAFCVGPA--PTSKSYLNMDAIMEAIRQTGAQAVHPGYGFLSENKEFARRLAADGVSFIGPDTHAIQAMGDKIESKLIAKAAKVNTIPGFDGVVKNAEEAVKIAGEIGYPVMIKASAGGGGKGMRIAWNDEETREGFRFSSQEAASSFGDDRLLIEKYIDNPRHIEIQVLADKHGNALWLNERECSIQRRNQKVVEEAPSTFLDPVTRRAMGEQAVSLAKAVKYSSAGTVEFLVDS-KKNFYFLEMNTRLQVEHPITECITGLDLVQQMIRVAKGYKLQH---KQEDIPINGWAIESRVYAEDPYKSFGLPSIGRLSQYEEPLNLPGVRVDSGIQ-EGSDISIYYDPMISKLVTYGSTRAEALKKMEDALDNYVIRGVTHNIPLLREIIVHPRFISGDISTNFLPEVYPEGFK 496

HSP 2 Score: 68.9366 bits (167), Expect = 2.602e-11
Identity = 47/158 (29.75%), Postives = 80/158 (50.63%), Query Frame = 3

Query: 3117 REEFGPVSKLGTRIFLVG-PRIAEEISVDLEKGKTLHIKTLAL-SDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRP-KAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            R  +    +L  R+ ++G  R     +V+++  K +      L S + P  + E+  +  G    V ++ K A+   ++ P K  +     + SPMPG V+ V VK GD+V +GQ +C+I AMKM+ S+ +    KVK VH      +   DL++E+E
Sbjct:  539 RRNWELCVELDKRVHMLGVSRSGNSYTVEIDGEKVVVSGEWNLASALLPLTINEITLQYLGTSFKVRVLSKLAASLNKLMPEKIPEDTSSILRSPMPGTVVAVSVKPGDTVAEGQEICVIEAMKMQNSMTAAKTAKVKSVHCTAGETVGEGDLLVELE 696

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BLAST of Pyruvate carboxylase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006397.1 (pep scaffold:Pmarinus_7.0:GL476470:932002:942971:-1 gene:ENSPMAG00000005777.1 transcript:ENSPMAT00000006397.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 632.098 bits (1629), Expect = 0.000e+0
Identity = 330/584 (56.51%), Postives = 424/584 (72.60%), Query Frame = 3

Query: 1872 GATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKF-CDLAVQSGMDIFRV-FDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKAD------------ELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            GATFDV+MRFL ECPW+RL+ +RKLIPN+PFQMLLRGANAVGYTNYPDN V+     + + S  +I  V    L Y    I+ +        V + +  +SG ++ P +     P  L+L      G AH+   KDMAG+LKP AAR+L+G LR +YPD+PIH+H+HDTAGAGVA+MLAAAE+G D+VD A+DSMSG+TSQPSMGA+VA LQ T LDTG++L+K++ YS YWE AR+LY PF+CT TM+SGN+DVY N+IPGGQYTNL FQ+ S+GL  +F+EVK+ YA AN LLGD+IKVTPSSKIVGDLAQFMVQN++  + + E+A+            ELSLPKSV+EF QG +G P GG+PE LRSK++K+ +   GRPG  L   DF   + +L      D   +D++S ++YP VF E++ F  +FGPV  L TR+FL GP+IAEE  V+LE+GKTL IK LAL D+   G REVFFELNGQLRSV + D +A K + V PKA KSV+G VG+PMPG V+E+KVKEG  V+KGQ LC++SAMKME  VN+P+ GK+  +HV P M +EG+DL++EIE
Sbjct:    1 GATFDVAMRFLYECPWKRLQKMRKLIPNVPFQMLLRGANAVGYTNYPDNSVFNPPSPVRINSNENIRTVRVHYLYYTAQHILYIKEHGNFTYVYDLAQRFSGALSPPARR----PCLLRLNG----GNAHLCNSKDMAGLLKPKAARMLVGALRERYPDMPIHVHTHDTAGAGVASMLAAAEAGADVVDVAVDSMSGMTSQPSMGALVASLQGTELDTGIDLQKVFDYSEYWEVARQLYAPFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGHKFKEVKKAYAEANKLLGDLIKVTPSSKIVGDLAQFMVQNRLTRQEVEERAEQTDPPEVRRGVHELSLPKSVVEFMQGAIGVPPGGYPEPLRSKILKDMERTEGRPGASLPPLDFVQLEKDLKGRHGRDITPEDVVSASMYPQVFDEYKEFTAQFGPVECLNTRLFLEGPQIAEEFQVELERGKTLIIKALALGDLN-KGHREVFFELNGQLRSVLVKDTKAMKNMHVHPKALKSVKGQVGAPMPGSVIEIKVKEGQQVEKGQPLCVLSAMKMETVVNAPMTGKIIKLHVQPSMHLEGDDLILEIE 575

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BLAST of Pyruvate carboxylase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006339.1 (pep scaffold:Pmarinus_7.0:GL476470:734267:771330:-1 gene:ENSPMAG00000005705.1 transcript:ENSPMAT00000006339.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 608.216 bits (1567), Expect = 0.000e+0
Identity = 349/727 (48.01%), Postives = 460/727 (63.27%), Query Frame = 3

Query: 1410 KTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQK--LLKYLGTLMVNGPVTVLATDLKPSL--------------INPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXES---GVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHV 3533
            +TNIPFL NVL N +F+ G+VDT FIDE+P LF  K  QNRAQK  LL   G +MVNG +T L    K +               I+        T   P+G+RD+LV  GP+AF  AV KH G L+ DT FRD HQSLLATRVRT+    ISPFVA +F NL+S+ENWGGA FDV+MRFL E PW+RL  +RKLIPN+PFQMLLRG N+ G  NYPD +  +  + A+   + +  V  C+ Y         ++ K   +V  S  Y G + +   ++      +     +++  A  +   D      P         LR  YPD+PIH+ + DTAGAGVA +LAAA +      +VD A+DSMSG+ S+P MG +VA LQ T LDTG++L+K++ YS YWE AR+LY PF+CT TM  GN+DVY N+IPGGQYTNL FQ  S+GL  +F+EVK+ YA  N LLGD+IKVTPSS IVGDLA  M+Q+ +  +       E+SLP+SV+EF QG   + +   P   +++++K+ +   GRPG  L   DF   + E +    H  D   ++S ++ P VF E++ F+ +F PV  L TR+FL GP+IAEE  V+L+ GKTL IK LAL D+   G REVFFELNGQLRSV + D +A K + V PKA KSV+G VG+PMPG V+E+KVKEG  V+KGQ LC++SAMKME  VN+P+ GK+  +HV
Sbjct:    1 QTNIPFLQNVLNNSQFVYGTVDTQFIDENPELFNLKPGQNRAQKAALLPGPGHVMVNGAMTPLPVKAKVTDVDPVVPDVPLVLDLIHSSSESMARTALLPSGFRDVLVTQGPEAFTMAVWKHRGLLLTDTPFRDVHQSLLATRVRTHARTAISPFVAHSFGNLYSIENWGGAKFDVAMRFLYERPWKRLLKMRKLIPNVPFQMLLRGTNSAGCANYPDPLRLRLGEGALTGEVPLACV--CVRYEDG------SLSKTSPIVVVS--YRGIVVNERVSENRTECQVSFVGRMLRWDAWTICFGDCMFTTTP--------RLRGHYPDMPIHVRTRDTAGAGVAPVLAAASARPPRQHVVDVAVDSMSGMNSRPGMG-LVASLQGTELDTGIDLQKVFDYSEYWEVARQLYAPFDCTATMTPGNSDVYENEIPGGQYTNLHFQVHSMGLGHKFKEVKKAYAEVNKLLGDLIKVTPSSMIVGDLALCMLQDGLTRQ-------EVSLPESVVEFMQGPTAQ-HXSPPTPHKARILKDMERTEGRPGASLPPPDF--VQLEKDPKGRHGRDTARVVSASVRPQVFDEYKEFKAQFWPVECLNTRLFL-GPQIAEEFQVELQWGKTLIIKALALGDLN-KGHREVFFELNGQLRSVLVKDTKAMKNMHVHPKALKSVKGQVGAPMPGSVIEIKVKEGQQVEKGQPLCVLSAMKMETMVNAPMTGKITKLHV 696

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BLAST of Pyruvate carboxylase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006346.1 (pep scaffold:Pmarinus_7.0:GL476470:805110:813016:1 gene:ENSPMAG00000005733.1 transcript:ENSPMAT00000006346.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 488.034 bits (1255), Expect = 1.715e-162
Identity = 250/358 (69.83%), Postives = 296/358 (82.68%), Query Frame = 3

Query:  159 VLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEV 1232
            V +   GEIA RVFRAC E+GIR+VA+YSEQD  Q+HR KADE+YLIGKGL PVAAYL+I +II++++ + VDAIHPGYGFLSERSDFA AC +A I+FIGP  +VVR+MGDKVEAR  A+ A V VVPG+  P+ +  EA  F + YG PII KAA+GGGGRGMRVV+  E L E+F RA SEALAAFGNG +FIEK+IE+PRHIEVQILGDK+GN VHL+ERDCS+QRRHQK+VEIAP  NL  S+R+ + +DAVKLAK VGYENAGTVEFL D+ + +HYFIEVN+RLQVEHTVTE +TGVDLV SQI IAEG+SLP LGL Q+ IR  G AIQCR+TTEDPAR FQPD+GR+EV
Sbjct:   40 VCIVALGEIATRVFRACTELGIRTVAVYSEQDNGQVHRQKADEAYLIGKGLAPVAAYLHIPDIIRVAQENAVDAIHPGYGFLSERSDFAQACLDADIRFIGPSPEVVRQMGDKVEARAIAISAGVPVVPGTEEPVVSLVEARHFCETYGFPIIFKAAFGGGGRGMRVVRSYEELEESFQRAYSEALAAFGNGSLFIEKYIEKPRHIEVQILGDKYGNVVHLYERDCSIQRRHQKVVEIAPGANLDPSMREHLTNDAVKLAKQVGYENAGTVEFLLDK-SGRHYFIEVNSRLQVEHTVTEQITGVDLVHSQIHIAEGRSLPSLGLHQDTIRINGCAIQCRVTTEDPARGFQPDTGRIEV 396

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BLAST of Pyruvate carboxylase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006351.1 (pep scaffold:Pmarinus_7.0:GL476470:805693:813506:1 gene:ENSPMAG00000005733.1 transcript:ENSPMAT00000006351.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 484.952 bits (1247), Expect = 6.386e-162
Identity = 249/357 (69.75%), Postives = 295/357 (82.63%), Query Frame = 3

Query:  159 VLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLE 1229
            V +   GEIA RVFRAC E+GIR+VA+YSEQD  Q+HR KADE+YLIGKGL PVAAYL+I +II++++ + VDAIHPGYGFLSERSDFA AC +A I+FIGP  +VVR+MGDKVEAR  A+ A V VVPG+  P+ +  EA  F + YG PII KAA+GGGGRGMRVV+  E L E+F RA SEALAAFGNG +FIEK+IE+PRHIEVQILGDK+GN VHL+ERDCS+QRRHQK+VEIAP  NL  S+R+ + +DAVKLAK VGYENAGTVEFL D+ + +HYFIEVN+RLQVEHTVTE +TGVDLV SQI IAEG+SLP LGL Q+ IR  G AIQCR+TTEDPAR FQPD+GR+E
Sbjct:    1 VCIVALGEIATRVFRACTELGIRTVAVYSEQDNGQVHRQKADEAYLIGKGLAPVAAYLHIPDIIRVAQENAVDAIHPGYGFLSERSDFAQACLDADIRFIGPSPEVVRQMGDKVEARAIAISAGVPVVPGTEEPVVSLVEARHFCETYGFPIIFKAAFGGGGRGMRVVRSYEELEESFQRAYSEALAAFGNGSLFIEKYIEKPRHIEVQILGDKYGNVVHLYERDCSIQRRHQKVVEIAPGANLDPSMREHLTNDAVKLAKQVGYENAGTVEFLLDK-SGRHYFIEVNSRLQVEHTVTEQITGVDLVHSQIHIAEGRSLPSLGLHQDTIRINGCAIQCRVTTEDPARGFQPDTGRIE 356

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BLAST of Pyruvate carboxylase vs. Ensembl Sea Lamprey
Match: pcca (propionyl-CoA carboxylase subunit alpha [Source:ZFIN;Acc:ZDB-GENE-040718-246])

HSP 1 Score: 289.656 bits (740), Expect = 1.346e-88
Identity = 158/361 (43.77%), Postives = 230/361 (63.71%), Query Frame = 3

Query:  117 YKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVA-AYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVV---KELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTE 1187
            Y +    ++K   K+L+ANRGEIA RV + C +MGI +VA++S+ D   +H   ADE++ +G    P A +YLN++ I+   K     A+HPGYGFLSE  +FA      G++FIGP    ++ MGDK+E++  A  A V  +PG  G ++  ++A++  ++ G P+++KA+ GGGG+GMR+    +E     E F  +  EA ++FG+  + IEKFI+ PRHIE+Q+L D+ GNA+ L ER+CSVQRR+QK+VE AP+  L    R  M   AV LA+ V Y +AGTVEFL D   +  YF+E+N RLQVEH +TE +TG+DLV   I +A G     L L+Q E+   G+AI+CR+  E
Sbjct:    3 YTATHDPSEKTFDKILIANRGEIACRVIKTCKKMGITTVAVHSDVDANAVHVKMADEAFCVGPA--PTAQSYLNMAAILDAVKTSGAQAVHPGYGFLSENKEFAKQLAAEGVKFIGPDTHALQAMGDKIESKLIAKTAGVNTIPGFDGVVKNTKDAVKIAREIGYPVMIKASAGGGGKGMRIAWNDEETNVRREGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLADEHGNALWLNERECSVQRRNQKVVEEAPSMFLDTQTRRAMGEQAVALARAVRYSSAGTVEFLVDSQRN-FYFLEMNTRLQVEHPITECITGLDLVMEMIRVAAGH---RLRLSQSEVPIRGWAIECRVYAE 357

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BLAST of Pyruvate carboxylase vs. Ensembl Yeast
Match: PYC2 (Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication [Source:SGD;Acc:S000000422])

HSP 1 Score: 1241.48 bits (3211), Expect = 0.000e+0
Identity = 627/1161 (54.01%), Postives = 840/1161 (72.35%), Query Frame = 3

Query:  156 KVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQ--PVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKI---PETPITHEY------------PTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKN-HKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDI-RPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            K+LVANRGEI IR+FR+ +E+ +R++AIYS +D + MHRLKADE+Y+IG+  Q  PV AYL + EII+I+K H VD IHPGYGFLSE S+FA    +AGI +IGPPA+V+  +GDKV AR  A  ANV  VPG+PGPI+T +EA++F  +YG P+I+KAA+GGGGRGMRVV+E + +++ F RA SEA  AFGNG  F+E+F+++P+HIEVQ+L D  GN VHLFERDCSVQRRHQK+VE+APA  L   +RD +L+DAVKLAK  GY NAGT EFL D   ++HYFIE+N R+QVEHT+TE++TG+D+V +QI IA G +L +LGL Q++I + G++IQCRITTEDP+++FQPD+GRLEV+RS  G G+RLD  +A+AGA ISP+YDS+L+K     + + +   KM+R+L EFR+RGVKTNIPFL  +L N  F+ G+  T FID+ P LFQ   SQNRAQKLL YL  L VNG      + +K  +  PK+   P  P  H+             P+GWR +L++ GP  FA+ VR+  G L+MDTT+RDAHQSLLATRVRT+D+A I+P  A      F+LE WGGATFDV+MRFL E PWERL  LR L+PNIPFQMLLRGAN V Y++ PDN +  F   A  +G+DIFRVFD LN L  + VG++AV KAGGVVEA+ CYSGD+  P K KYNL YYL++ + +V+ G HILGIKDMAG +KP AA++LIG LR++YPD+PIH+HSHD+AG  VA+M A A +G D+VD AI+SMSGLTSQPS+ A++A L+   +DTG+N+E +    +YW + R LY  FE    ++  + +VY ++IPGGQ TNL FQ+  LGL +Q+ E K+ Y  AN LLGD++KVTP+SK+VGDLAQFMV NK+ +  +   A+ L  P SV++FF+G +G+PYGGFPE LRS V++N  + +T RPG +L+ FD E  + +L + F  D D+ D+ SY +YP V+++FQ  RE +G +S L T+ FL      EEI V +E+GKTL IK  A+ D+ + +G REV+FELNG+LR + + DK  +     +PKA       +G+PM G ++EVKV +G  VKKG+++ ++SAMKMEM V+SP DG+VK V +     ++  DL++ +E
Sbjct:   22 KILVANRGEIPIRIFRSAHELSMRTIAIYSHEDRLSMHRLKADEAYVIGEEGQYTPVGAYLAMDEIIEIAKKHKVDFIHPGYGFLSENSEFADKVVKAGITWIGPPAEVIDSVGDKVSARHLAARANVPTVPGTPGPIETVQEALDFVNEYGYPVIIKAAFGGGGRGMRVVREGDDVADAFQRATSEARTAFGNGTCFVERFLDKPKHIEVQLLADNHGNVVHLFERDCSVQRRHQKVVEVAPAKTLPREVRDAILTDAVKLAKVCGYRNAGTAEFLVDN-QNRHYFIEINPRIQVEHTITEEITGIDIVSAQIQIAAGATLTQLGLLQDKITTRGFSIQCRITTEDPSKNFQPDTGRLEVYRSAGGNGVRLDGGNAYAGATISPHYDSMLVKCSCSGSTYEIVRRKMIRALIEFRIRGVKTNIPFLLTLLTNPVFIEGTYWTTFIDDTPQLFQMVSSQNRAQKLLHYLADLAVNG------SSIKGQIGLPKLKSNPSVPHLHDAQGNVINVTKSAPPSGWRQVLLEKGPSEFAKQVRQFNGTLLMDTTWRDAHQSLLATRVRTHDLATIAPTTAHALAGAFALECWGGATFDVAMRFLHEDPWERLRKLRSLVPNIPFQMLLRGANGVAYSSLPDNAIDHFVKQAKDNGVDIFRVFDALNDLEQLKVGVNAVKKAGGVVEATVCYSGDMLQPGK-KYNLDYYLEVVEKIVQMGTHILGIKDMAGTMKPAAAKLLIGSLRTRYPDLPIHVHSHDSAGTAVASMTACALAGADVVDVAINSMSGLTSQPSINALLASLEGN-IDTGINVEHVRELDAYWAEMRLLYSCFEA--DLKGPDPEVYQHEIPGGQLTNLLFQAQQLGLGEQWAETKRAYREANYLLGDIVKVTPTSKVVGDLAQFMVSNKLTSDDIRRLANSLDFPDSVMDFFEGLIGQPYGGFPEPLRSDVLRNKRRKLTCRPGLELEPFDLEKIREDLQNRFG-DIDECDVASYNMYPRVYEDFQKIRETYGDLSVLPTKNFLAPAEPDEEIEVTIEQGKTLIIKLQAVGDLNKKTGQREVYFELNGELRKIRVADKSQNIQSVAKPKADVHDTHQIGAPMAGVIIEVKVHKGSLVKKGESIAVLSAMKMEMVVSSPADGQVKDVFIKDGESVDASDLLVVLE 1170

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BLAST of Pyruvate carboxylase vs. Ensembl Yeast
Match: PYC1 (Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication [Source:SGD;Acc:S000003030])

HSP 1 Score: 1215.29 bits (3143), Expect = 0.000e+0
Identity = 624/1161 (53.75%), Postives = 835/1161 (71.92%), Query Frame = 3

Query:  156 KVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQ--PVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKI---PETPITHEY------------PTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKN-HKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDI-RPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            K+LVANRGEI IR+FR  +E+ +++VAIYS +D +  H+ KADE+Y+IG+  Q  PV AYL I EII I++ H VD IHPGYGFLSE S+FA    +AGI +IGPPA+V+  +GDKV AR  A  ANV  VPG+PGPI+T EEA++F  +YG P+I+KAA+GGGGRGMRVV+E + +++ F RA SEA  AFGNG  F+E+F+++P+HIEVQ+L D  GN VHLFERDCSVQRRHQK+VE+APA  L   +RD +L+DAVKLAK  GY NAGT EFL D   ++HYFIE+N R+QVEHT+TE++TG+D+V +QI IA G SLP+LGL Q++I + G+AIQCRITTEDPA++FQPD+GR+EV+RS  G G+RLD  +A+AG IISP+YDS+L+K     + + +   KM+R+L EFR+RGVKTNIPFL  +L N  F+ G+  T FID+ P LFQ   SQNRAQKLL YL  + VNG      + +K  +  PK+   P  P  H+             P+GWR +L++ GP  FA+ VR+  G L+MDTT+RDAHQSLLATRVRT+D+A I+P  A      F+LE WGGATFDV+MRFL E PWERL  LR L+PNIPFQMLLRGAN V Y++ PDN +  F   A  +G+DIFRVFD LN L  + VG+DAV KAGGVVEA+ C+SGD+  P K KYNL YYL++A+ +V+ G HILGIKDMAG +KP AA++LIG LR+KYPD+PIH+H+HD+AG  VA+M A A +G D+VD AI+SMSGLTSQPS+ A++A L+   +DTG+N+E +    +YW + R LY  FE    ++  + +VY ++IPGGQ TNL FQ+  LGL +Q+ E K+ Y  AN LLGD++KVTP+SK+VGDLAQFMV NK+ +  +   A+ L  P SV++FF+G +G+PYGGFPE  RS V++N  + +T RPG +L+ FD E  + +L + F  D D+ D+ SY +YP V+++FQ  RE +G +S L TR FL      EEI V +E+GKTL IK  A+ D+ + +G REV+F+LNG++R + + D+        + KA       +G+PM G ++EVKV +G  +KKGQ + ++SAMKMEM ++SP DG+VK V V+    ++  DL++ +E
Sbjct:   21 KILVANRGEIPIRIFRTAHELSMQTVAIYSHEDRLSTHKQKADEAYVIGEVGQYTPVGAYLAIDEIISIAQKHQVDFIHPGYGFLSENSEFADKVVKAGITWIGPPAEVIDSVGDKVSARNLAAKANVPTVPGTPGPIETVEEALDFVNEYGYPVIIKAAFGGGGRGMRVVREGDDVADAFQRATSEARTAFGNGTCFVERFLDKPKHIEVQLLADNHGNVVHLFERDCSVQRRHQKVVEVAPAKTLPREVRDAILTDAVKLAKECGYRNAGTAEFLVDN-QNRHYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGASLPQLGLFQDKITTRGFAIQCRITTEDPAKNFQPDTGRIEVYRSAGGNGVRLDGGNAYAGTIISPHYDSMLVKCSCSGSTYEIVRRKMIRALIEFRIRGVKTNIPFLLTLLTNPVFIEGTYWTTFIDDTPQLFQMVSSQNRAQKLLHYLADVAVNG------SSIKGQIGLPKLKSNPSVPHLHDAQGNVINVTKSAPPSGWRQVLLEKGPAEFARQVRQFNGTLLMDTTWRDAHQSLLATRVRTHDLATIAPTTAHALAGRFALECWGGATFDVAMRFLHEDPWERLRKLRSLVPNIPFQMLLRGANGVAYSSLPDNAIDHFVKQAKDNGVDIFRVFDALNDLEQLKVGVDAVKKAGGVVEATVCFSGDMLQPGK-KYNLDYYLEIAEKIVQMGTHILGIKDMAGTMKPAAAKLLIGSLRAKYPDLPIHVHTHDSAGTAVASMTACALAGADVVDVAINSMSGLTSQPSINALLASLEGN-IDTGINVEHVRELDAYWAEMRLLYSCFEA--DLKGPDPEVYQHEIPGGQLTNLLFQAQQLGLGEQWAETKRAYREANYLLGDIVKVTPTSKVVGDLAQFMVSNKLTSDDVRRLANSLDFPDSVMDFFEGLIGQPYGGFPEPFRSDVLRNKRRKLTCRPGLELEPFDLEKIREDLQNRFG-DVDECDVASYNMYPRVYEDFQKMRETYGDLSVLPTRSFLSPLETDEEIEVVIEQGKTLIIKLQAVGDLNKKTGEREVYFDLNGEMRKIRVADRSQKVETVTKSKADMHDPLHIGAPMAGVIVEVKVHKGSLIKKGQPVAVLSAMKMEMIISSPSDGQVKEVFVSDGENVDSSDLLVLLE 1169

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BLAST of Pyruvate carboxylase vs. Ensembl Yeast
Match: DUR1,2 (Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000000412])

HSP 1 Score: 331.257 bits (848), Expect = 4.133e-94
Identity = 182/446 (40.81%), Postives = 269/446 (60.31%), Query Frame = 3

Query:  159 VLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEH 1496
            VL+ANRGEIA+R+ +   ++GIRSVA+YS+ D    H   AD S  +  G      YL++++II  +K  +  AI PGYGFLSE +DF+ AC  AGI F+GP  D++R +G K  ARQ A  A V +VPGS   I + EEA +   +   P+++K+  GGGG G++ V   E +   F   + +    FG+  +F+E+FIE  RH+EVQ++GD FG A+ L ERDCS+QRR+QK++E  PAPNL    R  +   A  L   + Y+ AGTVEF+YD+  D+ YF+EVN RLQVEH +TE VTG+DLV   I IA   + P+   T+ E+   G +++ R+  E+P ++F+P  G L   +  +    R+D+     G  ISP YD  L K+I H  +   A +K+ ++L E +V G  TNI +L +++ ++ F    V T  ++ +
Sbjct:  636 VLIANRGEIAVRIIKTLKKLGIRSVAVYSDPDKYSQHVTDADVSVPL-HGTTAAQTYLDMNKIIDAAKQTNAQAIIPGYGFLSENADFSDACTSAGITFVGPSGDIIRGLGLKHSARQIAQKAGVPLVPGSL-LITSVEEAKKVAAELEYPVMVKSTAGGGGIGLQKVDSEEDIEHIFETVKHQGETFFGDAGVFLERFIENARHVEVQLMGDGFGKAIALGERDCSLQRRNQKVIEETPAPNLPEKTRLALRKAAESLGSLLNYKCAGTVEFIYDEKKDEFYFLEVNTRLQVEHPITEMVTGLDLVEWMIRIAANDA-PDFDSTKVEVN--GVSMEARLYAENPLKNFRPSPGLLVDVKFPDWA--RVDTWVK-KGTNISPEYDPTLAKIIVHGKDRDDAISKLNQALEETKVYGCITNIDYLKSIITSDFFAKAKVSTNILNSY 1073

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BLAST of Pyruvate carboxylase vs. Ensembl Yeast
Match: ACC1 (Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; ACC1 has a paralog, HFA1, that arose from the whole genome duplication [Source:SGD;Acc:S000005299])

HSP 1 Score: 234.572 bits (597), Expect = 5.417e-63
Identity = 161/513 (31.38%), Postives = 249/513 (48.54%), Query Frame = 3

Query:  150 IRKVLVANRGEIAIRVFRAC---------NEMGIRSVAIYSEQD-TMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAG--IQFIGPPADVVRKMGDKVEARQAALDANVTVVPGS------------------------PGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEG-----------------KSLPELGL-------TQEEIRSI--GYAIQCRITTEDPARDFQPDSGRLEV--FRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRG-VKTNIPFLFNVLENERFLNGSVDTYFIDE 1493
            I K+L+AN G  A++  R+          ++  ++ VA+ + +D       ++  + Y+   G      Y N+  I+ I++  DVDA+  G+G  SE         ++   + FIGPP + +R +GDK+ +   A  A V  +P S                         G   +PE+ ++  K+ G P+++KA+ GGGG+G+R V+      E+F     +A        +FI K   R RH+EVQ+L D++G  + LF RDCSVQRRHQKI+E AP          +M   AV+L K VGY +AGTVE+LY     K YF+E+N RLQVEH  TE V+GV+L  +Q+ IA G                  S  E+         T+++ R I  G+   CRIT+EDP   F+P  G L    FRS   +       S      I  + DS    + A   N + +   M+ +L+E  +RG  +T + +L  +LE E F + ++ T ++D+
Sbjct:   59 ISKILIANNGIAAVKEIRSVRKWAYETFGDDRTVQFVAMATPEDLEANAEYIRMADQYIEVPGGTNNNNYANVDLIVDIAERADVDAVWAGWGHASENPLLPEKLSQSKRKVIFIGPPGNAMRSLGDKISSTIVAQSAKVPCIPWSGTGVDTVHVDEKTGLVSVDDDIYQKGCCTSPEDGLQKAKRIGFPVMIKASEGGGGKGIRQVER----EEDFIALYHQAANEIPGSPIFIMKLAGRARHLEVQLLADQYGTNISLFGRDCSVQRRHQKIIEEAPVTIAKAETFHEMEKAAVRLGKLVGYVSAGTVEYLYSHDDGKFYFLELNPRLQVEHPTTEMVSGVNLPAAQLQIAMGIPMHRISDIRTLYGMNPHSASEIDFEFKTQDATKKQRRPIPKGHCTACRITSEDPNDGFKPSGGTLHELNFRSSSNV---WGYFSVGNNGNIHSFSDSQFGHIFAFGENRQASRKHMVVALKELSIRGDFRTTVEYLIKLLETEDFEDNTITTGWLDD 564

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BLAST of Pyruvate carboxylase vs. Ensembl Yeast
Match: HFA1 (Mitochondrial acetyl-coenzyme A carboxylase; catalyzes production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress; genetic and comparative analysis suggests that translation begins at a non-canonical (Ile) start codon at -372 relative to the annotated start codon [Source:SGD;Acc:S000004820])

HSP 1 Score: 231.491 bits (589), Expect = 5.441e-62
Identity = 147/436 (33.72%), Postives = 224/436 (51.38%), Query Frame = 3

Query:  327 YLNISEIIKISKMHDVDAIHPGYGFLSERSDFAA--ACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQT------------------------PEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEG------------KSLPELGLTQEEIRSI------GYAIQCRITTEDPARDFQPDSGRLEV--FRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRG-VKTNIPFLFNVLENERFLNGSVDTYFIDE 1493
            Y NI  I+ +++  DVDA+  G+G  SE        A  +  I FIGPP   +R +GDK+ +   A  A +  +P S   I T                        PE+A+E  K  G P+++KA+ GGGG+G+R V       ++F     +A+       MF+ K +   RH+EVQ+L D++G  + LF RDCS+QRRHQKI+E AP          +M   A++L + VGY +AGTVE+LY    DK YF+E+N RLQVEH  TE ++GV+L  +Q+ IA G              L   G +  + +++      G+ I CRIT+EDP   F+P +G++    FRS   +       +   GAI S + DS    + A   + + A   M+ +L++F +RG  KT I +L  +LE   F + ++ T ++D+
Sbjct:   54 YANIDLILDVAEQTDVDAVWAGWGHASENPCLPELLASSQRKILFIGPPGRAMRSLGDKISSTIVAQSAKIPCIPWSGSHIDTIHIDNKTNFVSVPDDVYVRGCCSSPEDALEKAKLIGFPVMIKASEGGGGKGIRRVDN----EDDFIALYRQAVNETPGSPMFVMKVVTDARHLEVQLLADQYGTNITLFGRDCSIQRRHQKIIEEAPVTITKPETFQRMERAAIRLGELVGYVSAGTVEYLYSPKDDKFYFLELNPRLQVEHPTTEMISGVNLPATQLQIAMGIPMHMISDIRKLYGLDPTGTSYIDFKNLKRPSPKGHCISCRITSEDPNEGFKPSTGKIHELNFRSSSNVWGYFSVGN--NGAIHS-FSDSQFGHIFAVGNDRQDAKQNMVLALKDFSIRGEFKTPIEYLIELLETRDFESNNISTGWLDD 482

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BLAST of Pyruvate carboxylase vs. Ensembl Nematostella
Match: EDO48484 (Pyruvate carboxylase [Source:UniProtKB/TrEMBL;Acc:A7RIZ1])

HSP 1 Score: 1543.48 bits (3995), Expect = 0.000e+0
Identity = 742/1152 (64.41%), Postives = 929/1152 (80.64%), Query Frame = 3

Query:  141 QKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPI----THEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLF-NHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            + +I+K+LVANRGEIAIRVFRA  E GIR+VAIYSEQD   MHR KADE+YL+GKG+ PVAAYLNI EII+I+K  + DAIHPGYGFLSER+DFA AC ++G+ FIGP   VV  MGDK+EAR+ A+++ V VVPG+  PI+T EEA +F +++GLP+I KAAYGGGGRGMRV+ ++E L E F  A +EA AAFG+G MFIEKFIE+PRHIEVQ++GD +G+ VHLFERDCSVQRRHQK++EIAPAP+L  +IR  +  DAV+L K VGY NAGTVEFL DQ    HYFIEVNARLQVEHTVTE++TGVDLVR+QI +AEGK+L ELGL Q+ I+  G AIQ R+TTEDPA +F PD+GR+EVFRSGEGMGIRLD +SAFAGA+ISP+YDSLL KVIAHA + R A  K+ RSLREFRVRGVKTN  F+ NVL+++ FL+G V T FI E+P++ +  K QNRAQKLLK++G +MVNGPVT+ AT LKPS I+PK+PE P+    ++  P+G+RD+ +  GP+ FA AVRK    LI DTTFRDAHQSLLATRVRT+DM +I+PFV+  F N FSLE WGGATFDV++RFL ECPW+RL  LR+ IPNIPFQMLLRGANAVGYT+YPDN+VY+FC  A   GMDIFRVFD LNYLPN+ +G+DA  +AG +VEA+  Y+GD+TDP++TKYN+ YY+ LA  L K G HIL IKDMAG+LKP AA +LIG LR+++P +PIH+H+HDTAGAGVA+MLAAAE+G D+VD A+DSMSG+TSQPSMGAVVA L+ T L+TG+ ++ ++ YS+YWEQAR LY PFE T TM+SGN+DVY N+IPGGQYTNL FQ++SLGL+DQF ++K+KYA+AN LLGDV+KVTP+SK+VGDLAQFMVQN +D + ++EKADEL  P SV+EF QG++GEP+GGFPE LRSK++K+  TI GRPG+ L  FDFEA + +L + F +H   D D++S ALYP VF ++  F++EFGPV  L TR+FL GP I EE  V LE GK LH+K LA+ D+ P+G REVF E+NGQLRSV I DK A+KT+ + PKA K V+GSVG+PMPG+V+ V+VKE + VKKG  L ++SAMKME +V++P+DG VK + V+    +E  DL+I+IE
Sbjct:   47 KHEIKKILVANRGEIAIRVFRAATEAGIRTVAIYSEQDANHMHRQKADEAYLVGKGMPPVAAYLNIPEIIRIAKERECDAIHPGYGFLSERADFAHACTKSGVIFIGPSPQVVHMMGDKLEARKMAINSGVPVVPGTENPIRTAEEAKQFCEEHGLPVITKAAYGGGGRGMRVIWKMEDLEEFFNLASNEAYAAFGDGSMFIEKFIEKPRHIEVQVMGDNYGDVVHLFERDCSVQRRHQKVIEIAPAPHLDDAIRQTLTEDAVRLCKAVGYSNAGTVEFLLDQ-EGNHYFIEVNARLQVEHTVTEEITGVDLVRAQIGVAEGKTLGELGLVQDNIKITGAAIQARVTTEDPANNFTPDTGRIEVFRSGEGMGIRLDGSSAFAGAVISPHYDSLLTKVIAHANSHREAATKLHRSLREFRVRGVKTNTEFIRNVLQHKDFLDGHVTTDFILENPDMLKVGKGQNRAQKLLKHIGNIMVNGPVTLGATGLKPSRIDPKVPEVPVHNSPSYIRPSGFRDLYLHKGPQGFASAVRKLDRLLITDTTFRDAHQSLLATRVRTHDMVKIAPFVSHYFANAFSLECWGGATFDVALRFLYECPWDRLTELREQIPNIPFQMLLRGANAVGYTSYPDNVVYQFCQKATDRGMDIFRVFDSLNYLPNLQLGIDAAGQAGAIVEAAISYTGDVTDPSRTKYNIDYYMDLASKLAKSGTHILCIKDMAGLLKPKAATLLIGSLRAQFPKLPIHVHTHDTAGAGVASMLAAAEAGADVVDVAVDSMSGMTSQPSMGAVVAALEGTELETGIAMQSVHDYSAYWEQARLLYAPFESTVTMKSGNSDVYENEIPGGQYTNLHFQAYSLGLSDQFSDIKKKYAIANKLLGDVVKVTPTSKVVGDLAQFMVQNNLDKRDVLEKADELDFPSSVVEFMQGYLGEPHGGFPEPLRSKIIKDKPTIKGRPGETLPPFDFEALETKLKEEFGDHSIRDVDVLSAALYPKVFHDYMVFKKEFGPVEGLPTRLFLNGPEIGEEFQVQLEAGKVLHLKVLAVGDLLPNGNREVFCEMNGQLRSVMIHDKGATKTLTLHPKADKGVKGSVGAPMPGKVVGVRVKENEVVKKGMPLVVLSAMKMETNVSAPIDGIVKKISVSLNSNVEAGDLLIDIE 1197

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BLAST of Pyruvate carboxylase vs. Ensembl Nematostella
Match: EDO48483 (Pyruvate carboxylase [Source:UniProtKB/TrEMBL;Acc:A7RIZ0])

HSP 1 Score: 1504.96 bits (3895), Expect = 0.000e+0
Identity = 717/1141 (62.84%), Postives = 915/1141 (80.19%), Query Frame = 3

Query:  162 LVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHD-FDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            +VANRGEIAIRVFRA  E GIR+VAIYSEQD   MHR KADE+YL+GKG+ PVAAYLNI EII+I+K  + DAIHPGYGFLSER+DFA AC ++GI FIGP   VV  MGDK+EAR+ A++A V VVPG+  PI+  E+A  F +++GLP+I KAAYGGGGRGMRV+  L+ + + FT A +EA AAFG+G MFIEKFIE+PRHIEVQ++GD +G+ VHLFERDCSVQRRHQK++EIAPAP L  +IR  +  DAV+L K VGY NAGTVEFL DQ    HYFIEVNARLQVEHTVTE++TG+DLVR+QI +AEGK+L ELGL Q+ I+  G AIQ R+TTEDPA +F PD+GR+EVFRSGEGMGIRLD +SAFAGA+ISP+YDSLL KVIAHA++ R A  K+ R+L E+R+RGVKTN  FL NVL+++ FLNG+V+T FI E+P+L + + S+NRAQKLL YLG ++VNGPVT LAT LKP+   P +P+T +    P G R+I ++ GP  FA+ VRK     + DTTFRDAHQSLLATRVRT+DM +I+PFV+  F N +SLE WGGATFDV++RFL ECPW+RL  LR+ IPNIPFQMLLRGANAVGYT+YPDN+V++FC  A   GMDIFRVFD LNY+PN+ +G+DA  +AG +VEA+  Y+GD+TDP++TKYN+ YY+ LA  L + GAH+L IKDMAG+LKP AA +L+G +R+++P +PIH+H+HDTAGAGVA+MLAAAE+G D+VD A+DSMSG+TSQPSMGAVVA L+ T LDTG+ L+ ++ YS+YWEQAR LY PFE T TM+SGN+DVY N+IPGGQYTNL FQ++SLGL+DQF E+K+KYA+AN LLGDV+KVTP+SK+VGDLAQFMVQN +D + ++EKADEL  P SV+EF QG++GEP+GGFPE LRSK++K+  TI GRPG+ L  FDF+A + +L + F  D   D D++S ALYP VF ++  F++EFGPV  L TR++  GP I EE  V L+ G+ L++K LA+ D+ P+G REVF E+NG LRSV + DK A+KT+ + PKA K+V+GSVG+PMPG+V+ V+VKE + VKKG +L ++SAMKME +V++P+DG+VK + V+  M +   DL++E+E
Sbjct:    1 MVANRGEIAIRVFRAATEAGIRTVAIYSEQDANHMHRQKADEAYLVGKGMPPVAAYLNIPEIIRIAKDKECDAIHPGYGFLSERADFARACTKSGIIFIGPSPQVVHMMGDKLEARKVAVEAGVPVVPGTAEPIRNAEDARAFCQEHGLPVITKAAYGGGGRGMRVIWNLDDVEKYFTLASNEAYAAFGDGSMFIEKFIEKPRHIEVQVMGDNYGDVVHLFERDCSVQRRHQKVIEIAPAPLLDENIRQTLTEDAVRLCKAVGYSNAGTVEFLLDQ-EGNHYFIEVNARLQVEHTVTEEITGIDLVRAQIGVAEGKTLGELGLVQDNIKITGAAIQARVTTEDPANNFTPDTGRIEVFRSGEGMGIRLDGSSAFAGAVISPHYDSLLTKVIAHASSHREAATKLHRALTEYRIRGVKTNTSFLMNVLKHDSFLNGTVNTDFILENPDLLKVRVSKNRAQKLLHYLGYILVNGPVTPLATGLKPAKKEPNVPQTYLQ---PQGLRNIFLREGPDGFARYVRKMDRLQLTDTTFRDAHQSLLATRVRTHDMVKIAPFVSHYFANAYSLECWGGATFDVALRFLNECPWDRLAELREQIPNIPFQMLLRGANAVGYTSYPDNVVHQFCKKAKDHGMDIFRVFDSLNYVPNLQLGIDAAGQAGAIVEAAISYTGDVTDPSRTKYNIDYYMDLATKLARSGAHVLCIKDMAGLLKPKAAHLLVGSIRAQFPKLPIHVHTHDTAGAGVASMLAAAEAGADVVDVAVDSMSGMTSQPSMGAVVAALEGTELDTGIALQSVHDYSAYWEQARLLYAPFESTVTMKSGNSDVYENEIPGGQYTNLHFQAYSLGLSDQFPEIKKKYAIANKLLGDVVKVTPTSKVVGDLAQFMVQNNLDERDVLEKADELDFPSSVVEFMQGYLGEPHGGFPEPLRSKIIKDKPTIKGRPGETLPPFDFDALEAKLKEDFGDDNIRDVDVLSAALYPKVFHDYMVFKKEFGPVEGLPTRLYFSGPEIGEEFQVQLQPGRMLNLKVLAIGDLLPNGTREVFCEMNGALRSVMVEDKSATKTLVLHPKADKAVKGSVGAPMPGKVVAVRVKENEVVKKGTSLVVLSAMKMETNVSAPIDGRVKKISVSQNMSLNAGDLLVELE 1137

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BLAST of Pyruvate carboxylase vs. Ensembl Nematostella
Match: EDO26946 (pep supercontig:ASM20922v1:NEMVEscaffold_5057:44:1594:-1 gene:NEMVEDRAFT_v1g152547 transcript:EDO26946 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 355.525 bits (911), Expect = 4.283e-114
Identity = 169/254 (66.54%), Postives = 207/254 (81.50%), Query Frame = 3

Query:  306 GLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTG 1067
            G+ PVAAYLNI EII+I+K  + DAIHPGYGFLSER+DFA AC ++G+ FIGP   VV  MGDK+EAR+ A+++ V VVPG+  PI+T EEA +F +++GLP+I KAAYGGGGRGMRV+ ++E L E F  A +EA AAFG+G MFIEKFIE+PRHIEVQ++GD +G+ VHLFERDCSVQRRHQK++EIAPAP+L  +IR  +  DAV+L K VGY NAGTVEFL DQ    HYFIEVNARLQVEHTVTE++TG
Sbjct:    2 GMPPVAAYLNIPEIIRIAKERECDAIHPGYGFLSERADFAHACTKSGVIFIGPSPQVVHMMGDKLEARKMAINSGVPVVPGTENPIRTAEEAKQFCEEHGLPVITKAAYGGGGRGMRVIWKMEDLEEFFNLASNEAYAAFGDGSMFIEKFIEKPRHIEVQVMGDNYGDVVHLFERDCSVQRRHQKVIEIAPAPHLDDAIRQTLTEDAVRLCKAVGYSNAGTVEFLLDQ-EGNHYFIEVNARLQVEHTVTEEITG 254

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BLAST of Pyruvate carboxylase vs. Ensembl Nematostella
Match: EDO44779 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUP0])

HSP 1 Score: 370.933 bits (951), Expect = 1.178e-113
Identity = 197/460 (42.83%), Postives = 284/460 (61.74%), Query Frame = 3

Query:  150 IRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSG-RLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEH-PNLFQFKKS 1523
            I K+LVANRGEIA RV      MG+++VA+YS  D   +H   ADE+Y IG       +YL + +I++++K     AIHPGYGFLSE  +FA  C E  I FIGPPA  +R MG K  ++    DA V ++ G  G  Q+ E   +  ++ G P++LKA  GGGG+GMR+V   +   E    A++E++ +F +  M +EKF+E PRH+EVQ+ GD+ GN V+L+ERDCSVQRRHQKI+E APAP ++  +R  +   AV+ AK VGY  AGTVEF+ D  +   YF+E+N RLQ +H +TE +TG+DLV  Q+ IA G+ LP   L Q+E++  G+A + R+  EDP+ DF P +G  L +    E   IR+D+     G  +S YYD ++ K++  +     A   +  SL+++ V G++TNI FL ++ ++  F  G V T FI +H  +LF  K S
Sbjct:   35 ISKILVANRGEIACRVMHTARRMGVQTVAVYSNADAKSLHVSLADEAYRIGPAPSS-ESYLKMHKIMEVAKKTGAQAIHPGYGFLSESPEFADLCQEENIIFIGPPASAIRDMGIKSTSKSIMSDAGVPIIQGYHGEDQSVERLQQEAERIGYPVMLKAVRGGGGKGMRIVNSPDEFHEMLESAKNESIKSFNDDSMLVEKFVETPRHVEVQVFGDRQGNVVYLYERDCSVQRRHQKIIEEAPAPGVSDEVRRSIGEAAVRAAKAVGYFGAGTVEFIMDS-SQNFYFMEMNTRLQAKHPITEMITGLDLVEWQLKIAAGEDLP---LKQDEVQLHGHAFEARVYAEDPSSDFLPGAGPLLHLTTPQETQHIRIDTG-VRQGDQVSTYYDPMIAKLVVWSETRPSALRLLKESLKKYNVVGLETNISFLTSLCDHNSFQAGDVHTDFIKQHMADLFPAKGS 488

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BLAST of Pyruvate carboxylase vs. Ensembl Nematostella
Match: EDO35168 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM69])

HSP 1 Score: 358.607 bits (919), Expect = 8.203e-111
Identity = 198/463 (42.76%), Postives = 284/463 (61.34%), Query Frame = 3

Query:  150 IRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEF---GKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSG-RLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEH-PNLFQFKKS 1523
            I K+LVANRGEIA RV      MG+++VA+YS+ D   +H   ADE+Y IG       +YL + +I++++K     AIHPGYGFLSE  +FA  C E  I FIGPPA  +R MG K  ++    DA V ++ G+   I +   ++ F     KY  P++LKA  GGGG+GMR+V   +   E    A++E++ +F +  M +EKF+E PRH+EVQ+ GD+ GN V+L+ERDCSVQRRHQKI+E APAP ++  +R  +   AV+ AK VGY  AGTVEF+ D  +   YF+E+N RLQ +H +TE +TG+DLV  Q+ IA G+ LP   L QEE++  G+A + R+  EDP+ DF P +G  L +    E   IR+D+     G  +S YYD ++ K++  +     A   +  SL+++ V G++TNI FL ++  +  F  G V T FI +H  +LF  K S
Sbjct:    1 ISKILVANRGEIACRVMHTARRMGVQTVAVYSDADAKSLHVSLADEAYRIGPAPSS-ESYLKMHKIMEVAKKTGAQAIHPGYGFLSESPEFADLCQEENIIFIGPPASAIRDMGIKSTSKSIMSDAGVPIIQGN---ILSSLLSIHFYSSTSKY--PVMLKAVRGGGGKGMRIVNSPDEFHEMLESAKNESIKSFNDDSMLVEKFVETPRHVEVQVFGDRQGNVVYLYERDCSVQRRHQKIIEEAPAPGVSDEVRRSIGEAAVRAAKAVGYFGAGTVEFIMDS-SQNFYFMEMNTRLQAKHPITEMITGLDLVEWQLKIAAGEDLP---LKQEEVQLHGHAFEARVYAEDPSSDFLPGAGPLLHLSTPQETQHIRIDTG-VRQGDQVSTYYDPMIAKLVVWSETRPSALRLLKESLKKYNVVGLETNISFLTSLCGHNSFQAGDVHTDFIKQHMADLFPAKGS 452

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BLAST of Pyruvate carboxylase vs. Ensembl Medaka
Match: pcxb (pyruvate carboxylase [Source:NCBI gene;Acc:101170548])

HSP 1 Score: 1212.59 bits (3136), Expect = 0.000e+0
Identity = 611/935 (65.35%), Postives = 734/935 (78.50%), Query Frame = 3

Query:  144 KKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKV 2948
            K I+KV+VANRGEIAIRVFRAC EMGIR+VA+YSEQDT QMHR KADE+YLIG+GL PVAAYL+I +IIK++K + VDAIHPGYGFLSER+DFA AC +AG++F+GP  D VRKMGDKVEAR  A  A V VVPG+  PI   ++A  F + YG PII KAAYGGGGRGMRVV+E E L EN+ RA SEAL AFGNG +F+EKFIE+PRHIEVQILGDK+GN +HL+ERDCS+QRRHQK+VEIAP   L   +RD++ SDAV LAK VGYENAGTVEFL D+   KHYFIEVN+RLQVEHTVTE++T    V                                                L+VFRSGEGMGIRLDSASAF GAIISP+YDSLL+KVIA   +   A +KM R+L EFRVRGVKTNIPFL NVL N +FL+ +VDT FIDE+P LF  K +QNRAQKLL YLG +MVNGP T +    KPS I+P +P   +  + P G+RD+L++ GP+ FA+AVR H G L+MDTTFRDAHQSLLATRVRT+D+ +ISPFV+ +F NLFSLENWGGATFDV+MRFL ECPW+RL+ LR LIPN+PFQMLLRGANAVGYTNYPDN V+KFC++A ++GMDIFRVFD LNYLPN+++GM+A   AGGVVEA+  Y+GD++DP + KY+L YY+ LAD+LVK G HIL IKDMAG+LKP ++++LIG LR ++PD+PIH+HSHDTAGAGVA MLA AE+G D+VD A+DSM+G+TSQPSMGA+VAC + T  DTG+ LEK++ YS YWE  R LY PF+CT TM+SGNADVY N+IPGGQYTNL FQ+ S+GL ++F+EVK+ YA AN LLGD+IKVTPSSKIVGDLAQFMVQN +  + + E+ADELS P+SV+EF QGHVG P+GGFPE  RSKV
Sbjct:   35 KPIKKVMVANRGEIAIRVFRACTEMGIRTVAVYSEQDTGQMHRQKADEAYLIGRGLPPVAAYLHIPDIIKVAKENGVDAIHPGYGFLSERADFAQACADAGVRFVGPTPDTVRKMGDKVEARSLANSAGVPVVPGTDAPISCLQDAQAFAQTYGFPIIFKAAYGGGGRGMRVVREYEELEENYQRAYSEALTAFGNGALFVEKFIEKPRHIEVQILGDKYGNVIHLYERDCSIQRRHQKVVEIAPGFQLDPHLRDRLHSDAVNLAKQVGYENAGTVEFLVDK-HGKHYFIEVNSRLQVEHTVTEEITDKPFV------------------------------------------------LQVFRSGEGMGIRLDSASAFQGAIISPHYDSLLVKVIASGKDLNTAASKMSRALAEFRVRGVKTNIPFLQNVLSNNQFLHSTVDTQFIDENPELFNLKPTQNRAQKLLHYLGHVMVNGPTTPIPVKAKPSSIDPVVPHVGMG-DPPVGFRDVLLRDGPEGFAKAVRAHQGLLLMDTTFRDAHQSLLATRVRTHDLKKISPFVSHSFSNLFSLENWGGATFDVAMRFLSECPWKRLQELRALIPNVPFQMLLRGANAVGYTNYPDNAVFKFCEVAKENGMDIFRVFDSLNYLPNMLLGMEAAGAAGGVVEAAISYTGDVSDPMRQKYSLDYYVNLADELVKAGTHILCIKDMAGLLKPTSSQLLIGALRDRFPDVPIHVHSHDTAGAGVAAMLACAEAGADVVDVAVDSMAGMTSQPSMGAIVACTKGTKYDTGIALEKVFDYSEYWEVTRGLYAPFDCTATMKSGNADVYENEIPGGQYTNLHFQAHSMGLGNKFKEVKKAYAEANKLLGDLIKVTPSSKIVGDLAQFMVQNSLTRQEVEERADELSFPQSVVEFLQGHVGIPHGGFPEPFRSKV 919

HSP 2 Score: 169.859 bits (429), Expect = 2.461e-42
Identity = 79/129 (61.24%), Postives = 103/129 (79.84%), Query Frame = 3

Query: 3195 VDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            V+LE+GKTLHIK LAL D+  +G REVFFE+NGQLRSV + D  A K ++  PKA+KS++G VG+PMPG+VLEVKVK G  V+KGQ LC++SAMKME  VNSP+ G +K +HV+P   +EG+DL++EIE
Sbjct:  919 VELERGKTLHIKALALGDLNKNGQREVFFEMNGQLRSVLVKDTVAMKEMKFHPKAQKSIKGQVGAPMPGKVLEVKVKTGSKVEKGQPLCVLSAMKMETVVNSPMAGTIKAIHVSPDASLEGDDLILEIE 1047

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BLAST of Pyruvate carboxylase vs. Ensembl Medaka
Match: mccc1 (methylcrotonoyl-CoA carboxylase 1 [Source:NCBI gene;Acc:101161876])

HSP 1 Score: 365.925 bits (938), Expect = 1.761e-111
Identity = 197/476 (41.39%), Postives = 282/476 (59.24%), Query Frame = 3

Query:  144 KKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEH-PNLFQFKKSQNRAQKLLKYLGTLM 1568
            ++I KVL+ANRGEIA RV R   +MG+RSVA+YSE D   MH   ADE+Y IG       +YL++ ++++++K     A+HPGYGFLSE ++FA AC   GI FIGPP+  +R MG K  ++     A V ++ G  G  Q+ E  +    K G P+++KA  GGGG+GMR+ +      E    A+ EA  +F +  M +EKF+E PRH+EVQ+ GD  GNAV+LFERDCSVQRRHQKI+E AP P ++  +R K+   AV+ AK V Y  AGTVEF+ D      YF+E+N RLQVEH VTE +TG DLV  Q+ +A G+ LP   L Q++I   G++ + RI  EDP  +F P +G L    +               G  +S +YD ++ K++    +   A  K+   LR++ + G+ TNI FL ++  +  F  G+V T FI +H  +LF   ++ + A      LG ++
Sbjct:   20 ERIEKVLIANRGEIACRVMRTAKKMGVRSVAVYSEADKSSMHVAMADEAYHIGPPPSQ-QSYLSVEKVLEVAKKSGSHAVHPGYGFLSENTEFAEACKREGIIFIGPPSSAIRDMGIKSTSKHIMSAAGVPIIGGYHGEDQSNERLLAEAAKIGFPVMIKAVRGGGGKGMRIARSETDFLEQLESARREARKSFNDDVMLVEKFVEDPRHVEVQVFGDTHGNAVYLFERDCSVQRRHQKIIEEAPGPGISPEVRKKLGEAAVRAAKAVNYVGAGTVEFIVD-AQHNFYFMEMNTRLQVEHPVTEMITGTDLVEWQLRVAAGERLP---LLQDDIILRGHSFEARIYAEDPNNEFLPGAGPLLHLSTPPADRHTRIETGVREGDEVSAHYDPMIAKLVVWGEDRSAALKKLRYCLRQYNIVGLNTNIDFLLSLSGHPEFEAGNVSTSFIPQHYSDLFPTPRAPSGATICQAALGLIL 490

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BLAST of Pyruvate carboxylase vs. Ensembl Medaka
Match: mccc1 (methylcrotonoyl-CoA carboxylase 1 [Source:NCBI gene;Acc:101161876])

HSP 1 Score: 365.925 bits (938), Expect = 2.887e-111
Identity = 197/476 (41.39%), Postives = 282/476 (59.24%), Query Frame = 3

Query:  144 KKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEH-PNLFQFKKSQNRAQKLLKYLGTLM 1568
            ++I KVL+ANRGEIA RV R   +MG+RSVA+YSE D   MH   ADE+Y IG       +YL++ ++++++K     A+HPGYGFLSE ++FA AC   GI FIGPP+  +R MG K  ++     A V ++ G  G  Q+ E  +    K G P+++KA  GGGG+GMR+ +      E    A+ EA  +F +  M +EKF+E PRH+EVQ+ GD  GNAV+LFERDCSVQRRHQKI+E AP P ++  +R K+   AV+ AK V Y  AGTVEF+ D      YF+E+N RLQVEH VTE +TG DLV  Q+ +A G+ LP   L Q++I   G++ + RI  EDP  +F P +G L    +               G  +S +YD ++ K++    +   A  K+   LR++ + G+ TNI FL ++  +  F  G+V T FI +H  +LF   ++ + A      LG ++
Sbjct:   38 ERIEKVLIANRGEIACRVMRTAKKMGVRSVAVYSEADKSSMHVAMADEAYHIGPPPSQ-QSYLSVEKVLEVAKKSGSHAVHPGYGFLSENTEFAEACKREGIIFIGPPSSAIRDMGIKSTSKHIMSAAGVPIIGGYHGEDQSNERLLAEAAKIGFPVMIKAVRGGGGKGMRIARSETDFLEQLESARREARKSFNDDVMLVEKFVEDPRHVEVQVFGDTHGNAVYLFERDCSVQRRHQKIIEEAPGPGISPEVRKKLGEAAVRAAKAVNYVGAGTVEFIVD-AQHNFYFMEMNTRLQVEHPVTEMITGTDLVEWQLRVAAGERLP---LLQDDIILRGHSFEARIYAEDPNNEFLPGAGPLLHLSTPPADRHTRIETGVREGDEVSAHYDPMIAKLVVWGEDRSAALKKLRYCLRQYNIVGLNTNIDFLLSLSGHPEFEAGNVSTSFIPQHYSDLFPTPRAPSGATICQAALGLIL 508

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BLAST of Pyruvate carboxylase vs. Ensembl Medaka
Match: pcca (propionyl-CoA carboxylase subunit alpha [Source:NCBI gene;Acc:101175100])

HSP 1 Score: 334.724 bits (857), Expect = 5.498e-100
Identity = 190/470 (40.43%), Postives = 287/470 (61.06%), Query Frame = 3

Query:  141 QKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQ-PDSGRLEVFRSGEGMG-IRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDE-HPNLF---QFKKSQNR 1532
            ++  +K+L+ANRGEIA RV + C  MGI+++A++S+ D+  +H   ADE+  +G     ++ YLN+  I+   +     A+HPGYGFLSE  +FA       + FIGP    ++ MGDK++++  A  A V  +PG  G +++ E+A++  ++ G P+++KA+ GGGG+GMR+    E   E F  +  EA ++FG+  + IEK+I+RPRHIE+Q+L DK GNA+ L ER+CS+QRR+QK+VE AP+  L  + R  M   AV+LAK V Y +AGTVEFL D      YF+E+N RLQVEH +TE +TG+DLV   I +A+G  L      QE+I   G+AI+ R+  EDP + F  P  GRL  ++    +  +R+DS     G+ IS YYD ++ K++        A A+M  SL  + +RGV  NIP L  ++ +  F++G + T F+ E +P  F   Q +  Q R
Sbjct:   46 EETFQKLLIANRGEIACRVIKTCKRMGIQTIAVHSDVDSNAVHVKMADEAVCVGPAPTSLS-YLNMDAILNAVRRTGAQAVHPGYGFLSENKEFAKRLAAEDVTFIGPDTHAIQAMGDKIQSKLIAKAAKVNTIPGFDGVVKSAEDAVKIAQQIGYPVMIKASAGGGGKGMRIAWNDEETREGFRFSSQEAASSFGDDRLLIEKYIDRPRHIEIQVLADKHGNALWLNERECSIQRRNQKVVEEAPSTFLDPTTRRAMGEQAVQLAKAVQYSSAGTVEFLVD-AQKNFYFLEMNTRLQVEHPITECITGLDLVEQMIRVAKGYRLQH---KQEDIPINGWAIESRVYAEDPFKSFGLPSIGRLSQYQEPLDLSNVRVDSGIE-EGSDISIYYDPMISKLVTFGATRAEALARMEESLDRYVIRGVTHNIPLLREIITHPLFISGDISTNFLPEVYPEGFKGHQLEAEQRR 509

HSP 2 Score: 68.1662 bits (165), Expect = 3.766e-11
Identity = 39/104 (37.50%), Postives = 57/104 (54.81%), Query Frame = 3

Query: 3273 VFFELNGQLRSVEIVDKEASKTIRVRP-KAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            +  +  G L  V ++ K ASK     P K  +     + SPMPG V+ V V  GD+V +GQ +C+I AMKM+ S+ +    KVK VH  P   +   DL++E+E
Sbjct:  611 IALQFMGTLFKVRVLSKLASKLNSYMPEKLPEDTSSILRSPMPGTVVAVSVHPGDTVAEGQEICVIEAMKMQNSLTAVKQAKVKSVHCKPGETVGEGDLLVELE 714

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BLAST of Pyruvate carboxylase vs. Ensembl Medaka
Match: acacb (acetyl-CoA carboxylase beta [Source:NCBI gene;Acc:101171338])

HSP 1 Score: 238.424 bits (607), Expect = 2.663e-63
Identity = 165/516 (31.98%), Postives = 256/516 (49.61%), Query Frame = 3

Query:  150 IRKVLVANRGEIAIRVFRAC---------NEMGIRSVAIYSEQDTMQMHRLKADESYL-IGKGLQPVAA------YLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGS---------------------------PGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSI-----------------------GYAIQCRITTEDPARDFQPDSGRLEV--FRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRG-VKTNIPFLFNVLENERFLNGSVDTYFID 1490
            I KVL+AN G  A++  R+          NE  IR V + + +D      LKA+  Y+ +     PV        Y N+  I+ I+K   V  +  G+G  SE        H+AGI F+GP +  +  +GDKV +   A  A++  +P S                            G ++  E+ +   ++ G P+++KA+ GGGG+G+R V+  E     F + Q+E   +     +F+ +  +  RH+EVQIL D++GNA+ LF RDCS+QRRHQKI+E APA   A S  ++M   AV++AK VGY +AGTVE+LY +    H F+E+N RLQVEH  TE +  V+L  +Q+ IA G  L  +    ++IR +                       G+ I  RIT+E+P   F+P SG ++   FRS + +     S  A  G  +  + DS      +   N   A + M+ +L+E  +RG  +T + +L  +LE E + N  +DT ++D
Sbjct:  197 IEKVLIANNGIAAVKCMRSIRRWSYEMFRNERTIRFVVMVTPED------LKANAEYIKMADHYVPVPGGSNNNNYANVELIVDIAKRIPVQGVWAGWGHASENPKLPELLHKAGISFLGPSSKAMWALGDKVASSIVAQSADIPTLPWSGSGLKVDWTEEDQTQGKVISVPPEVYNEGCVRDVEDGLAGAERIGYPVVIKASEGGGGKGIRKVENSEDFPGFFRQVQTEVPGS----PIFVMQLAQHARHLEVQILADEYGNAISLFGRDCSIQRRHQKIIEEAPATIAASSTLEQMEQYAVRMAKMVGYVSAGTVEYLYSEDGSFH-FLELNPRLQVEHPCTEMIGDVNLPAAQLQIAMGIPLSRI----KDIRLLYGESPWGDTHINFEVPYRLPSPRGHVIAVRITSENPDEGFKPSSGTVQELNFRSSKNVWGYF-SVGATGG--LHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLIKILETESYRNNEIDTGWLD 694

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BLAST of Pyruvate carboxylase vs. Planmine SMEST
Match: SMESG000077941.1 (SMESG000077941.1)

HSP 1 Score: 2419.81 bits (6270), Expect = 0.000e+0
Identity = 1183/1183 (100.00%), Postives = 1183/1183 (100.00%), Query Frame = 3

Query:   33 MSAMFQAIKLKCKPNFHSKFLFHNSGINYKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDXXXXXXXXXXXXXESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            MSAMFQAIKLKCKPNFHSKFLFHNSGINYKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDTAGAGVATMLAAAESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE
Sbjct:    1 MSAMFQAIKLKCKPNFHSKFLFHNSGINYKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNRAQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDILVKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVAQNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRGANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHKAGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAGVLKPNAARILIGELRSKYPDIPIHLHSHDTAGAGVATMLAAAESGVDIVDCAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLYGPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYAVANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVIEFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELNDLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIAEEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEASKTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 1183

[Close]

BLAST of Pyruvate carboxylase vs. Planmine SMEST
Match: SMESG000034830.1 (SMESG000034830.1)

HSP 1 Score: 345.125 bits (884), Expect = 8.321e-104
Identity = 192/514 (37.35%), Postives = 311/514 (60.51%), Query Frame = 3

Query:   54 IKLKC---KPNFH---SKFLFHNSGINYKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQ-PDSGRLEVFRSGEGM-GIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDE-HPNLFQFKKSQNRAQKLLKYLGTLM 1568
            +++KC    P  H   +KF      I +       + K +K+L+ANRGEIA R+  +C   GI++VA++S+ D +      ADE+  IG   Q   +YLN+ +I+   K    +A+HPGYGFLSE + FA    +  + F+GP +  +  MGDK+E+++ A  A V  +PG  G I   +EA++   + G P+++KA+ GGGG+GMR+    +   E +  +++EA ++FG+  M IEK+I +PRHIE+QI+ DK GNA++L ER+CS+QRR+QK++E AP+  +    R  M   AV++AK VGY++AGTVEFL D   +  YF+E+N RLQVEH ++E +TGVD+V     + +G  L    L Q +I   G+A++CR+  EDP + F  P  GRL  ++    +  +R DS     G+ IS YYD ++ K++ +  +   A A M+++L  + +RGV  NIP L +++   RF++G++ T ++ E +P+ F+ K+   +   LL+ +  ++
Sbjct:    2 LRIKCFISLPTLHGSSNKFSSAARNIYWNDKHDPKETKFKKILIANRGEIACRIINSCKRFGIKAVAVHSDVDALSRFVQMADEAICIGPA-QTSLSYLNMEKILDAVKQTGAEAVHPGYGFLSENTVFAKKLEDMNVVFLGPNSKAIHSMGDKIESKRIANAAKVHCIPGYDGEINDTDEAIKIANQIGYPVMIKASAGGGGKGMRIAWNDKEAVEGYKLSRAEAKSSFGDDRMLIEKYINKPRHIEIQIMCDKHGNALYLNERECSIQRRNQKVIEEAPSTFINPETRKAMGEQAVQMAKAVGYDSAGTVEFLVDDKRN-FYFLEMNTRLQVEHPISELITGVDIVHQMFRVGKGHPLL---LKQSDISVNGWAVECRVYAEDPYKSFGLPSVGRLTSYKEPLHLPNVRCDSGIQ-EGSEISIYYDPMICKLVTYGEDRSKALATMVKALDSYVIRGVTHNIPLLRDIVTEPRFVSGNITTNYLPEVYPDGFKGKQLTPKETGLLEAMSAVV 509

HSP 2 Score: 57.3806 bits (137), Expect = 6.432e-8
Identity = 30/77 (38.96%), Postives = 42/77 (54.55%), Query Frame = 3

Query: 3351 PKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            PK        + +PMPG V  V VK G  V  GQ LC++ AMKM+ S+ +   G +K VH  P   +   D++IE+E
Sbjct:  637 PKKVVDTSSVIIAPMPGLVKTVSVKVGQRVSDGQELCVLEAMKMQNSMVAAKAGVIKAVHFQPGQTVSDGDIIIELE 713

[Close]

BLAST of Pyruvate carboxylase vs. Planmine SMEST
Match: SMESG000034830.1 (SMESG000034830.1)

HSP 1 Score: 345.125 bits (884), Expect = 8.430e-104
Identity = 192/514 (37.35%), Postives = 311/514 (60.51%), Query Frame = 3

Query:   54 IKLKC---KPNFH---SKFLFHNSGINYKSDQILTQKKIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQ-PDSGRLEVFRSGEGM-GIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDE-HPNLFQFKKSQNRAQKLLKYLGTLM 1568
            +++KC    P  H   +KF      I +       + K +K+L+ANRGEIA R+  +C   GI++VA++S+ D +      ADE+  IG   Q   +YLN+ +I+   K    +A+HPGYGFLSE + FA    +  + F+GP +  +  MGDK+E+++ A  A V  +PG  G I   +EA++   + G P+++KA+ GGGG+GMR+    +   E +  +++EA ++FG+  M IEK+I +PRHIE+QI+ DK GNA++L ER+CS+QRR+QK++E AP+  +    R  M   AV++AK VGY++AGTVEFL D   +  YF+E+N RLQVEH ++E +TGVD+V     + +G  L    L Q +I   G+A++CR+  EDP + F  P  GRL  ++    +  +R DS     G+ IS YYD ++ K++ +  +   A A M+++L  + +RGV  NIP L +++   RF++G++ T ++ E +P+ F+ K+   +   LL+ +  ++
Sbjct:    2 LRIKCFISLPTLHGSSNKFSSAARNIYWNDKHDPKETKFKKILIANRGEIACRIINSCKRFGIKAVAVHSDVDALSRFVQMADEAICIGPA-QTSLSYLNMEKILDAVKQTGAEAVHPGYGFLSENTVFAKKLEDMNVVFLGPNSKAIHSMGDKIESKRIANAAKVHCIPGYDGEINDTDEAIKIANQIGYPVMIKASAGGGGKGMRIAWNDKEAVEGYKLSRAEAKSSFGDDRMLIEKYINKPRHIEIQIMCDKHGNALYLNERECSIQRRNQKVIEEAPSTFINPETRKAMGEQAVQMAKAVGYDSAGTVEFLVDDKRN-FYFLEMNTRLQVEHPISELITGVDIVHQMFRVGKGHPLL---LKQSDISVNGWAVECRVYAEDPYKSFGLPSVGRLTSYKEPLHLPNVRCDSGIQ-EGSEISIYYDPMICKLVTYGEDRSKALATMVKALDSYVIRGVTHNIPLLRDIVTEPRFVSGNITTNYLPEVYPDGFKGKQLTPKETGLLEAMSAVV 509

HSP 2 Score: 57.3806 bits (137), Expect = 6.752e-8
Identity = 30/77 (38.96%), Postives = 42/77 (54.55%), Query Frame = 3

Query: 3351 PKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKMEMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE 3581
            PK        + +PMPG V  V VK G  V  GQ LC++ AMKM+ S+ +   G +K VH  P   +   D++IE+E
Sbjct:  646 PKKVVDTSSVIIAPMPGLVKTVSVKVGQRVSDGQELCVLEAMKMQNSMVAAKAGVIKAVHFQPGQTVSDGDIIIELE 722

[Close]

BLAST of Pyruvate carboxylase vs. Planmine SMEST
Match: SMESG000025190.1 (SMESG000025190.1)

HSP 1 Score: 310.842 bits (795), Expect = 4.287e-92
Identity = 189/511 (36.99%), Postives = 279/511 (54.60%), Query Frame = 3

Query:  147 KIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKH--YFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPAR--DFQPDSGRLEVFRSGE-GMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPN-LFQFKKSQNRAQKLLKYLGTLM-VNGPVTVLATDLKPSLINPKIPETPITHEY 1658
            +I K+L+ANRGEIA RV +    MGI ++A+YSE D   +H   A +SY IG     ++ YLN  +++ +++M    AIHPGYGFLSE  +FAA C+                                       G  Q  +  +E   K G PI++KA  GGGG+GMR+        E    A+ EA+ +F +  M +EKFIE PRH+EVQ+ GD +GN VHL ERDCSVQRRHQKI+E AP P +   IRD++   AVK A  V Y  AGTVEF+ D    KH  YF+E+N RLQVEH +TE +TG DLV  Q+ +A G+ LP   + Q  I+  G+A + RI  ED      F P +G ++  R  E    +R+D+     G  IS +YD ++ K++  + +   A  K+  +L  +++ G+ TNI FL ++  +  F++G V T FI +H + LF  +KS+ R   +   +  ++    P+ + +++ + S    ++P   I H +
Sbjct:    5 RISKILIANRGEIACRVIKTAKRMGIETIAVYSEADRNSLHAKMASQSYCIGPAASQLS-YLNAEKLLSVAQMTKSQAIHPGYGFLSENVEFAALCYH--------------------------------------GNNQNKDYLLEEATKIGFPIMIKAVRGGGGKGMRICLSKNEFFEQLESAKREAIKSFNDDAMLLEKFIETPRHVEVQVFGDSYGNYVHLCERDCSVQRRHQKIIEEAPGPGITAEIRDRLGKAAVKAAAAVSYVGAGTVEFIMDA---KHNFYFMEMNTRLQVEHPITEMITGTDLVEWQLRVASGERLPI--IDQALIQPKGHAFEARIYAEDCTNPTAFMPTAGLIKHMRLPEINENVRIDTG-VLEGDEISVHYDPMISKLVVWSHDRSSALQKLTMALNSYQIVGLPTNIEFLKSLSLHPSFIDGLVHTDFIKQHTDSLFAVEKSETRDVSIAAAVSVMIDSQHPIVIDSSEDRYSPFATQLPGFRINHNF 470

[Close]

BLAST of Pyruvate carboxylase vs. Planmine SMEST
Match: SMESG000025178.1 (SMESG000025178.1)

HSP 1 Score: 298.13 bits (762), Expect = 2.532e-87
Identity = 186/511 (36.40%), Postives = 278/511 (54.40%), Query Frame = 3

Query:  147 KIRKVLVANRGEIAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYLNISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVRKMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAYGGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEVQILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVKLAKFVGYENAGTVEFLYDQVTDKH--YFIEVNARLQVEHTVTEDVTGVDLVRSQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPAR--DFQPDSGRLEVFRSGE-GMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRSLREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPN-LFQFKKSQNRAQKLLKYLGTLM-VNGPVTVLATDLKPSLINPKIPETPITHEY 1658
            +I K+L+ANRGEIA RV +    MGI ++A+YSE D   +H   A +SY IG     ++ YLN  +++ +++M    AIHPGYGFLSE  +FAA C    + FIGPP   +R MG K  ++     A V VV G  G  Q  +  +E   K G PI++KA  GGGG+GMR+        E    A+ EA+ +F +  M +EKFIE PRH+EVQ+ G                     KI+E AP P +   IRD++   AVK A  V Y  AGTVEF+ D    KH  YF+E+N RLQVEH +TE +TG DLV  Q+ +A G+ LP   + Q  I+  G+A + RI  ED      F P +G ++  R  E    +R+D+     G  IS +YD ++ K++  + +   A  K+  +L  +++ G+ TNI FL ++  +  F++G V T FI +H + LF  +KS+ R   +   +  ++    P+ + +++ + S    ++P   I H +
Sbjct:    5 RISKILIANRGEIACRVIKTAKRMGIETIAVYSEADRNSLHAKMASQSYCIGPAASQLS-YLNAEKLLSVAQMTKSQAIHPGYGFLSENVEFAALCKANNVIFIGPPESAIRDMGIKNTSKSIMEAAGVPVVKGYHGNNQNKDYLLEEATKIGFPIMIKAVRGGGGKGMRICLSKNEFFEQLESAKREAIKSFNDDAMLLEKFIETPRHVEVQVFGIV------------------TKIIEEAPGPGITAEIRDRLGKAAVKAAAAVSYVGAGTVEFIMDA---KHNFYFMEMNTRLQVEHPITEMITGTDLVEWQLRVASGERLPI--IDQALIQPKGHAFEARIYAEDCTNPTAFMPTAGLIKHMRLPEINENVRIDTG-VLEGDEISVHYDPMISKLVVWSHDRSSALQKLTMALNSYQIVGLPTNIEFLKSLSLHPSFIDGLVHTDFIKQHTDSLFAVEKSETRDVSIAAAVSVMIDSQHPIVIDSSEDRYSPFATQLPGFRINHNF 490

The following BLAST results are available for this feature:

BLAST of Pyruvate carboxylase vs. Ensembl Human
BLAST of Pyruvate carboxylase vs. Ensembl Celegans
BLAST of Pyruvate carboxylase vs. Ensembl Fly
BLAST of Pyruvate carboxylase vs. Ensembl Zebrafish
BLAST of Pyruvate carboxylase vs. Ensembl Xenopus
BLAST of Pyruvate carboxylase vs. Ensembl Mouse
BLAST of Pyruvate carboxylase vs. UniProt/SwissProt
BLAST of Pyruvate carboxylase vs. TrEMBL
BLAST of Pyruvate carboxylase vs. Ensembl Cavefish
BLAST of Pyruvate carboxylase vs. Ensembl Sea Lamprey
BLAST of Pyruvate carboxylase vs. Ensembl Yeast
BLAST of Pyruvate carboxylase vs. Ensembl Nematostella
BLAST of Pyruvate carboxylase vs. Ensembl Medaka
BLAST of Pyruvate carboxylase vs. Planmine SMEST

BLAST of Pyruvate carboxylase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PC	0.000e+0	64.66	pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:...	[more]
PC	0.000e+0	64.66	pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:...	[more]
PC	0.000e+0	64.66	pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:...	[more]
PC	0.000e+0	64.66	pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:...	[more]
PC	0.000e+0	64.66	pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:...	[more]

BLAST of Pyruvate carboxylase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pyc-1	0.000e+0	66.96	Pyruvate carboxylase 1 [Source:UniProtKB/Swiss-Pr...	[more]
pyc-1	0.000e+0	66.96	Pyruvate carboxylase 1 [Source:UniProtKB/Swiss-Pr...	[more]
pyc-1	0.000e+0	65.53	Pyruvate carboxylase 1 [Source:UniProtKB/Swiss-Pr...	[more]
mccc-1	1.537e-110	45.81	MethylCrotonoyl-Coenzyme A Carboxylase (Alpha) [S...	[more]
mccc-1	1.537e-110	45.81	MethylCrotonoyl-Coenzyme A Carboxylase (Alpha) [S...	[more]

BLAST of Pyruvate carboxylase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PCB	0.000e+0	67.49	gene:FBgn0027580 transcript:FBtr0088455	[more]
PCB	0.000e+0	67.49	gene:FBgn0027580 transcript:FBtr0088457	[more]
PCB	0.000e+0	67.49	gene:FBgn0027580 transcript:FBtr0088456	[more]
PCB	0.000e+0	67.49	gene:FBgn0027580 transcript:FBtr0088459	[more]
PCB	0.000e+0	67.49	gene:FBgn0027580 transcript:FBtr0088462	[more]

BLAST of Pyruvate carboxylase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pcxa	0.000e+0	66.64	pyruvate carboxylase a [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
pcxa	0.000e+0	66.64	pyruvate carboxylase a [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
pcxb	0.000e+0	66.23	pyruvate carboxylase b [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
pcxb	0.000e+0	70.37	pyruvate carboxylase b [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
mccc1	1.154e-110	42.29	methylcrotonoyl-CoA carboxylase 1 (alpha) [Source:...	[more]

BLAST of Pyruvate carboxylase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hoxd3	0.000e+0	66.75	homeobox D3 [Source:Xenbase;Acc:XB-GENE-478462]	[more]
hoxd3	0.000e+0	66.93	homeobox D3 [Source:Xenbase;Acc:XB-GENE-478462]	[more]
hoxd3	0.000e+0	66.93	homeobox D3 [Source:Xenbase;Acc:XB-GENE-478462]	[more]
hoxd3	0.000e+0	66.93	homeobox D3 [Source:Xenbase;Acc:XB-GENE-478462]	[more]
hoxd3	4.846e-41	69.28	homeobox D3 [Source:Xenbase;Acc:XB-GENE-478462]	[more]

BLAST of Pyruvate carboxylase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Pcx	0.000e+0	64.32	pyruvate carboxylase [Source:MGI Symbol;Acc:MGI:97...	[more]
Pcx	0.000e+0	64.32	pyruvate carboxylase [Source:MGI Symbol;Acc:MGI:97...	[more]
Pcx	0.000e+0	64.32	pyruvate carboxylase [Source:MGI Symbol;Acc:MGI:97...	[more]
Mccc1	1.816e-109	44.44	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) [...	[more]
Pcca	1.011e-105	42.73	propionyl-Coenzyme A carboxylase, alpha polypeptid...	[more]

BLAST of Pyruvate carboxylase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|O17732\|PYC1_CAEEL	0.000e+0	66.96	Pyruvate carboxylase 1 OS=Caenorhabditis elegans O...	[more]
sp\|P11498\|PYC_HUMAN	0.000e+0	64.66	Pyruvate carboxylase, mitochondrial OS=Homo sapien...	[more]
sp\|Q29RK2\|PYC_BOVIN	0.000e+0	64.84	Pyruvate carboxylase, mitochondrial OS=Bos taurus ...	[more]
sp\|P52873\|PYC_RAT	0.000e+0	64.23	Pyruvate carboxylase, mitochondrial OS=Rattus norv...	[more]
sp\|Q05920\|PYC_MOUSE	0.000e+0	64.23	Pyruvate carboxylase, mitochondrial OS=Mus musculu...	[more]

BLAST of Pyruvate carboxylase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A4Z2CX27	0.000e+0	70.72	Pyruvate carboxylase OS=Schistosoma japonicum OX=6...	[more]
A0A3Q0KND4	0.000e+0	69.95	Pyruvate carboxylase OS=Schistosoma mansoni OX=618...	[more]
A0A094ZHZ7	0.000e+0	69.52	Pyruvate carboxylase OS=Schistosoma haematobium OX...	[more]
K1QHI5	0.000e+0	67.08	Pyruvate carboxylase, mitochondrial OS=Crassostrea...	[more]
A0A0P5LPJ2	0.000e+0	68.42	Pyruvate carboxylase, mitochondrial OS=Daphnia mag...	[more]

BLAST of Pyruvate carboxylase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pcxb	0.000e+0	66.52	pyruvate carboxylase b [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
pcxb	8.467e-39	68.33	pyruvate carboxylase b [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
mccc1	6.683e-113	42.22	methylcrotonoyl-CoA carboxylase 1 [Source:NCBI gen...	[more]
ENSAMXT00000052136.1	1.620e-111	59.60	pep primary_assembly:Astyanax_mexicanus-2.0:14:189...	[more]
pcca	2.670e-103	41.87	propionyl-CoA carboxylase subunit alpha [Source:ZF...	[more]

BLAST of Pyruvate carboxylase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000006397.1	0.000e+0	56.51	pep scaffold:Pmarinus_7.0:GL476470:932002:942971:-...	[more]
ENSPMAT00000006339.1	0.000e+0	48.01	pep scaffold:Pmarinus_7.0:GL476470:734267:771330:-...	[more]
ENSPMAT00000006346.1	1.715e-162	69.83	pep scaffold:Pmarinus_7.0:GL476470:805110:813016:1...	[more]
ENSPMAT00000006351.1	6.386e-162	69.75	pep scaffold:Pmarinus_7.0:GL476470:805693:813506:1...	[more]
pcca	1.346e-88	43.77	propionyl-CoA carboxylase subunit alpha [Source:ZF...	[more]

BLAST of Pyruvate carboxylase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
PYC2	0.000e+0	54.01	Pyruvate carboxylase isoform; cytoplasmic enzyme t...	[more]
PYC1	0.000e+0	53.75	Pyruvate carboxylase isoform; cytoplasmic enzyme t...	[more]
DUR1,2	4.133e-94	40.81	Urea amidolyase; contains both urea carboxylase an...	[more]
ACC1	5.417e-63	31.38	Acetyl-CoA carboxylase, biotin containing enzyme; ...	[more]
HFA1	5.441e-62	33.72	Mitochondrial acetyl-coenzyme A carboxylase; catal...	[more]

BLAST of Pyruvate carboxylase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO48484	0.000e+0	64.41	Pyruvate carboxylase [Source:UniProtKB/TrEMBL;Acc...	[more]
EDO48483	0.000e+0	62.84	Pyruvate carboxylase [Source:UniProtKB/TrEMBL;Acc...	[more]
EDO26946	4.283e-114	66.54	pep supercontig:ASM20922v1:NEMVEscaffold_5057:44:1...	[more]
EDO44779	1.178e-113	42.83	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35168	8.203e-111	42.76	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Pyruvate carboxylase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pcxb	2.461e-42	65.35	pyruvate carboxylase [Source:NCBI gene;Acc:1011705...	[more]
mccc1	1.761e-111	41.39	methylcrotonoyl-CoA carboxylase 1 [Source:NCBI gen...	[more]
mccc1	2.887e-111	41.39	methylcrotonoyl-CoA carboxylase 1 [Source:NCBI gen...	[more]
pcca	5.498e-100	40.43	propionyl-CoA carboxylase subunit alpha [Source:NC...	[more]
acacb	2.663e-63	31.98	acetyl-CoA carboxylase beta [Source:NCBI gene;Acc:...	[more]

BLAST of Pyruvate carboxylase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000077941.1	0.000e+0	100.00	SMESG000077941.1	[more]
SMESG000034830.1	8.321e-104	37.35	SMESG000034830.1	[more]
SMESG000034830.1	8.430e-104	37.35	SMESG000034830.1	[more]
SMESG000025190.1	4.287e-92	36.99	SMESG000025190.1	[more]
SMESG000025178.1	2.532e-87	36.40	SMESG000025178.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30024713 ID=SMED30024713|Name=Pyruvate carboxylase|organism=Schmidtea mediterranea sexual|type=transcript|length=3655bp
CTATATAAATCTTATATGATTCTTATTTAAAAATGTCTGCTATGTTTCAA
GCGATAAAATTAAAATGCAAACCTAATTTTCATTCTAAGTTTTTGTTTCA
TAATTCAGGAATTAATTATAAATCAGATCAGATATTAACACAGAAAAAAA
TTCGAAAGGTTTTAGTTGCGAATCGAGGAGAAATTGCTATTCGCGTTTTT
CGAGCATGTAATGAAATGGGAATTCGGTCAGTGGCCATTTATAGTGAACA
GGACACGATGCAAATGCATCGTTTAAAAGCCGATGAATCGTATTTAATTG
GCAAAGGCTTACAACCAGTAGCGGCTTATTTGAACATTAGTGAAATAATT
AAAATTTCAAAAATGCATGATGTCGACGCTATTCATCCGGGATATGGGTT
TTTAAGTGAACGCTCGGATTTTGCAGCAGCTTGCCATGAAGCTGGAATAC
AATTTATTGGTCCACCGGCAGATGTCGTGCGTAAGATGGGTGACAAAGTC
GAGGCAAGACAAGCTGCATTAGATGCCAATGTCACTGTGGTTCCAGGAAG
CCCAGGGCCGATTCAGACACCAGAAGAAGCAATGGAGTTTGGTAAGAAAT
ACGGTTTGCCAATTATATTGAAAGCAGCATATGGTGGAGGTGGACGTGGG
ATGCGAGTAGTTAAAGAATTGGAGACTTTATCTGAAAATTTTACTCGAGC
CCAGTCGGAAGCTTTAGCCGCTTTTGGAAACGGTGAAATGTTCATTGAAA
AATTTATTGAAAGACCAAGACACATTGAAGTTCAAATATTAGGTGACAAG
TTCGGCAATGCTGTGCATCTATTCGAAAGAGATTGTAGTGTTCAAAGGAG
ACATCAGAAAATTGTTGAAATCGCCCCAGCTCCAAATTTAGCAGTTTCAA
TAAGAGATAAAATGTTGTCAGATGCCGTTAAATTAGCAAAATTTGTTGGA
TATGAAAATGCCGGGACTGTTGAGTTTCTGTACGACCAAGTAACAGATAA
ACATTATTTTATCGAAGTCAATGCTAGATTGCAAGTTGAACATACAGTGA
CAGAAGATGTTACCGGAGTGGATTTAGTACGATCTCAAATTTTGATAGCC
GAAGGTAAAAGTTTACCGGAGCTTGGTCTTACCCAAGAAGAAATAAGATC
AATTGGATATGCGATTCAATGTCGAATTACAACCGAAGATCCCGCTCGTG
ATTTCCAACCTGATTCTGGTAGATTGGAGGTTTTTCGAAGTGGAGAAGGA
ATGGGTATACGTCTCGATTCTGCAAGTGCTTTTGCTGGAGCAATTATTTC
TCCGTATTATGACTCATTATTAATTAAAGTCATAGCTCATGCGACTAATT
TTCGATTGGCTTGTGCCAAAATGTTGCGATCACTTAGAGAATTTAGAGTT
AGAGGTGTAAAGACAAATATTCCATTTCTTTTCAATGTCCTCGAAAACGA
ACGTTTTTTAAATGGAAGTGTCGATACGTACTTTATTGATGAACATCCAA
ATCTGTTTCAGTTTAAAAAATCTCAAAATCGAGCACAGAAATTGCTGAAA
TATTTAGGTACATTAATGGTAAATGGACCGGTGACTGTGCTTGCTACAGA
TTTGAAACCGTCTTTAATAAATCCCAAAATTCCTGAAACTCCAATTACGC
ATGAGTATCCTACTGGGTGGAGAGATATTCTAGTAAAATCAGGCCCGAAA
GCTTTTGCGCAGGCAGTTAGAAAACATCCAGGATGTTTAATAATGGATAC
GACATTTAGAGATGCCCATCAATCTTTATTGGCCACTCGAGTCAGGACGT
ATGATATGGCGGAAATTAGTCCCTTTGTGGCGCAAAACTTTCCTAATCTA
TTCAGCTTGGAAAACTGGGGAGGCGCAACATTTGATGTTTCTATGAGATT
TTTGAAAGAGTGCCCGTGGGAACGATTGGAAACATTGAGAAAATTGATTC
CAAATATTCCATTTCAAATGCTATTAAGAGGAGCAAACGCAGTTGGCTAT
ACTAACTATCCAGATAACATTGTATATAAGTTCTGTGACCTAGCCGTTCA
ATCAGGAATGGATATTTTCCGAGTTTTTGACTGTCTTAATTATTTACCTA
ATATTATTGTTGGTATGGATGCGGTTCATAAAGCTGGGGGTGTTGTTGAG
GCGTCATTTTGCTACAGTGGTGATATTACTGATCCAACGAAAACCAAATA
TAATCTTCCGTATTATTTGAAACTTGCCGATGATTTGGTTAAAGGAGGGG
CTCATATCCTTGGTATCAAAGACATGGCAGGTGTATTGAAACCGAATGCC
GCAAGAATCCTCATCGGTGAATTACGAAGCAAATATCCGGACATACCCAT
TCATTTACATTCTCACGATACAGCTGGAGCCGGAGTAGCTACAATGTTAG
CTGCTGCAGAGTCCGGAGTTGATATTGTAGATTGTGCCATAGATTCGATG
TCAGGTCTCACTAGTCAGCCTTCAATGGGAGCCGTCGTTGCCTGTTTACA
AAATACACCTTTAGATACAGGATTGAATTTGGAAAAAATTTACTCTTATT
CGTCATATTGGGAACAGGCACGAAGGCTTTATGGGCCTTTTGAGTGCACA
ACAACTATGCGTAGTGGTAATGCTGATGTTTATCATAATCAAATCCCTGG
GGGTCAATATACCAATCTTCAATTCCAATCTTTCTCTCTTGGATTAGCAG
ATCAATTCGAAGAAGTTAAGCAAAAATATGCTGTTGCAAATGATCTGTTG
GGAGATGTTATCAAAGTAACCCCTTCATCAAAAATAGTTGGTGATTTAGC
ACAATTCATGGTTCAAAATAAAATAGACGCTAAAACCTTAGTTGAGAAAG
CTGATGAATTGTCACTTCCTAAATCGGTTATTGAATTTTTTCAAGGTCAT
GTTGGTGAACCATATGGTGGCTTTCCGGAAAAATTACGATCTAAAGTCGT
TAAAAATCATAAAACTATAACTGGTCGACCAGGAGATGACCTAAAGGCAT
TTGATTTTGAAGCTGCCAAGTTTGAATTAAATGACCTATTCAATCATGAT
TTCGATGACAAAGACATCATGTCATACGCATTGTATCCAGCTGTTTTCAA
AGAATTCCAATATTTTCGAGAGGAATTTGGACCGGTTTCTAAATTAGGGA
CTAGAATATTTTTAGTTGGACCCAGAATTGCCGAAGAGATTTCAGTAGAC
CTCGAAAAAGGAAAAACACTGCATATTAAAACATTAGCTCTTAGTGATAT
AAGGCCCAGTGGAGTTCGAGAGGTATTTTTTGAATTGAACGGGCAACTGA
GATCCGTTGAAATAGTTGATAAAGAAGCATCAAAAACTATTCGAGTACGG
CCGAAAGCGAAAAAAAGCGTTCGGGGATCAGTGGGATCACCTATGCCAGG
CGAAGTATTAGAAGTAAAAGTAAAAGAGGGCGACAGTGTTAAAAAAGGCC
AAACACTCTGCATTATTAGTGCAATGAAAATGGAAATGTCAGTCAATTCT
CCGGTTGATGGTAAAGTGAAAGTTGTACACGTAGCACCTAAAATGAAAAT
TGAAGGTGAAGATCTAATGATAGAGATAGAATAGACTTGATTTTTTTCTT
ATTTTATTTATATTTGTTCAAGTTTTTGATTTTTAATACATAGATTTAGT
TAAAA

protein sequence of SMED30024713-orf-1

>SMED30024713-orf-1 ID=SMED30024713-orf-1|Name=SMED30024713-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1184bp
MSAMFQAIKLKCKPNFHSKFLFHNSGINYKSDQILTQKKIRKVLVANRGE
IAIRVFRACNEMGIRSVAIYSEQDTMQMHRLKADESYLIGKGLQPVAAYL
NISEIIKISKMHDVDAIHPGYGFLSERSDFAAACHEAGIQFIGPPADVVR
KMGDKVEARQAALDANVTVVPGSPGPIQTPEEAMEFGKKYGLPIILKAAY
GGGGRGMRVVKELETLSENFTRAQSEALAAFGNGEMFIEKFIERPRHIEV
QILGDKFGNAVHLFERDCSVQRRHQKIVEIAPAPNLAVSIRDKMLSDAVK
LAKFVGYENAGTVEFLYDQVTDKHYFIEVNARLQVEHTVTEDVTGVDLVR
SQILIAEGKSLPELGLTQEEIRSIGYAIQCRITTEDPARDFQPDSGRLEV
FRSGEGMGIRLDSASAFAGAIISPYYDSLLIKVIAHATNFRLACAKMLRS
LREFRVRGVKTNIPFLFNVLENERFLNGSVDTYFIDEHPNLFQFKKSQNR
AQKLLKYLGTLMVNGPVTVLATDLKPSLINPKIPETPITHEYPTGWRDIL
VKSGPKAFAQAVRKHPGCLIMDTTFRDAHQSLLATRVRTYDMAEISPFVA
QNFPNLFSLENWGGATFDVSMRFLKECPWERLETLRKLIPNIPFQMLLRG
ANAVGYTNYPDNIVYKFCDLAVQSGMDIFRVFDCLNYLPNIIVGMDAVHK
AGGVVEASFCYSGDITDPTKTKYNLPYYLKLADDLVKGGAHILGIKDMAG
VLKPNAARILIGELRSKYPDIPIHLHSHDTAGAGVATMLAAAESGVDIVD
CAIDSMSGLTSQPSMGAVVACLQNTPLDTGLNLEKIYSYSSYWEQARRLY
GPFECTTTMRSGNADVYHNQIPGGQYTNLQFQSFSLGLADQFEEVKQKYA
VANDLLGDVIKVTPSSKIVGDLAQFMVQNKIDAKTLVEKADELSLPKSVI
EFFQGHVGEPYGGFPEKLRSKVVKNHKTITGRPGDDLKAFDFEAAKFELN
DLFNHDFDDKDIMSYALYPAVFKEFQYFREEFGPVSKLGTRIFLVGPRIA
EEISVDLEKGKTLHIKTLALSDIRPSGVREVFFELNGQLRSVEIVDKEAS
KTIRVRPKAKKSVRGSVGSPMPGEVLEVKVKEGDSVKKGQTLCIISAMKM
EMSVNSPVDGKVKVVHVAPKMKIEGEDLMIEIE*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000026	gut
PLANA:0000034	epidermis
PLANA:0000070	intestinal phagocyte
PLANA:0000099	neuron
PLANA:0000101	muscle cell
PLANA:0000103	central nervous system
PLANA:0003116	parenchymal cell
PLANA:0003117	parapharyngeal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR005482	Biotin_COase_C
IPR009057	Homeobox-like_sf
IPR005930	Pyruv_COase
IPR000891	PYR_CT
IPR005481	BC-like_N
IPR016185	PreATP-grasp_dom_sf
IPR013815	ATP_grasp_subdomain_1
IPR003379	Carboxylase_cons_dom
IPR013785	Aldolase_TIM
IPR000089	Biotin_lipoyl
IPR005479	CbamoylP_synth_lsu-like_ATP-bd
IPR013816	ATP_grasp_subdomain_2
IPR001882	Biotin_BS
IPR011761	ATP-grasp
IPR011764	Biotin_carboxylation_dom
IPR011054	Rudment_hybrid_motif
IPR011053	Single_hybrid_motif

Vocabulary: **molecular function**
Term	Definition
GO:0003677	DNA binding
GO:0005524	ATP binding
GO:0009374	biotin binding
GO:0004736	pyruvate carboxylase activity
GO:0003824	catalytic activity
GO:0046872	metal ion binding
GO:0004075	biotin carboxylase activity
GO:0000166	nucleotide binding
GO:0016874	ligase activity

Vocabulary: **biological process**
Term	Definition
GO:0006094	gluconeogenesis
GO:0006090	pyruvate metabolic process
GO:0008152	metabolic process

Vocabulary: **cellular component**
Term	Definition
GO:0005737	cytoplasm
GO:0005739	mitochondrion

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR005482	Biotin carboxylase, C-terminal	SMART	SM00878	Biotin_carb_C_2	coord: 384..491 e-value: 4.9E-48 score: 175.6
IPR005482	Biotin carboxylase, C-terminal	PFAM	PF02785	Biotin_carb_C	coord: 384..492 e-value: 9.0E-31 score: 106.2
IPR005481	Biotin carboxylase-like, N-terminal domain	PFAM	PF00289	Biotin_carb_N	coord: 45..153 e-value: 7.5E-41 score: 139.1
None	No IPR available	GENE3D	G3DSA:2.40.50.100		coord: 1111..1188 e-value: 5.7E-23 score: 82.5
None	No IPR available	GENE3D	G3DSA:1.10.472.90		coord: 859..991 e-value: 1.7E-288 score: 960.1
None	No IPR available	GENE3D	G3DSA:3.30.470.130		coord: 33..499 e-value: 1.4E-192 score: 642.2
None	No IPR available	GENE3D	G3DSA:1.10.10.60		coord: 992..1038 e-value: 1.7E-288 score: 960.1
None	No IPR available	GENE3D	G3DSA:3.10.600.10		coord: 503..1101 e-value: 1.7E-288 score: 960.1
None	No IPR available	PANTHER	PTHR43778	FAMILY NOT NAMED	coord: 36..1188
None	No IPR available	CDD	cd07937	DRE_TIM_PC_TC_5S	coord: 575..858 e-value: 2.18898E-164 score: 486.168
None	No IPR available	CDD	cd06850	biotinyl_domain	coord: 1122..1187 e-value: 2.06909E-26 score: 100.954
None	No IPR available	SUPERFAMILY	SSF89000	post-HMGL domain-like	coord: 876..1052
None	No IPR available	SUPERFAMILY	SSF51569	Aldolase	coord: 570..879
None	No IPR available	SUPERFAMILY	SSF56059	Glutathione synthetase ATP-binding domain-like	coord: 127..398
IPR005479	Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain	PFAM	PF02786	CPSase_L_D2	coord: 159..368 e-value: 2.1E-76 score: 256.1
IPR005479	Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain	PROSITE	PS00867	CPSASE_2	coord: 331..338
IPR005930	Pyruvate carboxylase	TIGRFAM	TIGR01235	TIGR01235	coord: 47..1188 e-value: 0.0 score: 1843.1
IPR005930	Pyruvate carboxylase	PIRSF	PIRSF001594	PCB	coord: 40..1188 e-value: 0.0 score: 1785.5
IPR003379	Carboxylase, conserved domain	PFAM	PF02436	PYC_OADA	coord: 871..1071 e-value: 9.2E-67 score: 224.6
IPR000089	Biotin/lipoyl attachment	PFAM	PF00364	Biotin_lipoyl	coord: 1122..1187 e-value: 7.8E-17 score: 60.9
IPR000089	Biotin/lipoyl attachment	PROSITE	PS50968	BIOTINYL_LIPOYL	coord: 1113..1188 score: 26.546
IPR013785	Aldolase-type TIM barrel	GENE3D	G3DSA:3.20.20.70		coord: 537..858 e-value: 1.7E-288 score: 960.1
IPR000891	Pyruvate carboxyltransferase	PFAM	PF00682	HMGL-like	coord: 575..846 e-value: 4.7E-27 score: 95.2
IPR000891	Pyruvate carboxyltransferase	PROSITE	PS50991	PYR_CT	coord: 573..842 score: 37.871
IPR001882	Biotin-binding site	PROSITE	PS00188	BIOTIN	coord: 1144..1161
IPR011764	Biotin carboxylation domain	PROSITE	PS50979	BC	coord: 44..495 score: 53.129
IPR011761	ATP-grasp fold	PROSITE	PS50975	ATP_GRASP	coord: 166..362 score: 42.415
IPR016185	Pre-ATP-grasp domain superfamily	SUPERFAMILY	SSF52440	PreATP-grasp domain	coord: 35..157
IPR011054	Rudiment single hybrid motif	SUPERFAMILY	SSF51246	Rudiment single hybrid motif	coord: 380..498
IPR011053	Single hybrid motif	SUPERFAMILY	SSF51230	Single hybrid motif	coord: 1111..1188