G_PROTEIN_RECEP_F1_2 domain-containing protein

Overview
NameG_PROTEIN_RECEP_F1_2 domain-containing protein
Smed IDSMED30024636
Length (bp)1440
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of G_PROTEIN_RECEP_F1_2 domain-containing protein (SMED30024636) t-SNE clustered cells

Violin plots show distribution of expression levels for G_PROTEIN_RECEP_F1_2 domain-containing protein (SMED30024636) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of G_PROTEIN_RECEP_F1_2 domain-containing protein (SMED30024636) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for G_PROTEIN_RECEP_F1_2 domain-containing protein (SMED30024636) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30024636

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
epidermisSMED30024636h1SMcG0013854 dd_Smed_v4_6788_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30024636h1SMcG0013854 dd_Smed_v4_6788_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Category 4 cellSMED30024636h1SMcG0013854 dd_Smed_v4_6788_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Human
Match: GPR139 (G protein-coupled receptor 139 [Source:HGNC Symbol;Acc:HGNC:19995])

HSP 1 Score: 63.5438 bits (153), Expect = 2.637e-10
Identity = 65/235 (27.66%), Postives = 113/235 (48.09%), Query Frame = 2 
Query:  563 FAARTCSIYTIVIVTVERFIMVLFPMK-RTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDK--SHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALV----KCHLNDMRKYRDNLVTETTS 1246
            F++   SI+  V +T++R+I V  P+K  T        K+++SV ++   L SIP+++  +I +     +S SV +  +WI+       + L+PC I  + NS I+Y LR +    L     +     K   I L  ++ +F  L  P +++I  H       ++   H+    A+  A+      +N AINF +YCF  K FRT A A +    KC    ++ Y ++  + T+S
Sbjct:  109 FSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSV-YITCFLTSIPYYWWPNIWTEDY--ISTSVHHVLIWIHCFT----VYLVPCSIFFILNSIIVYKLRRKSNFRL-----RGYSTGKTTAI-LFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLAL------LNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSS 324
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Human
Match: GHSR (growth hormone secretagogue receptor [Source:HGNC Symbol;Acc:HGNC:4267])

HSP 1 Score: 53.5286 bits (127), Expect = 4.716e-7
Identity = 57/233 (24.46%), Postives = 103/233 (44.21%), Query Frame = 2 
Query:  557 FTFAARTCSIYTIVIVT---VERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIA---------SHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYA--ISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRK 1213
            F F + +C+  T++ +T   VER+  + FP++     T    K+++ V++ V+   + P F    +          ++ C P   +VR+  L +   + S+I   +P   + V  S I   L  R R + +V  S   +  K     L VV F F +  +P    +G +  ++ + +   L  A+   Y   +S +LF ++ AIN I+Y    K +R A   L+       RK
Sbjct:  119 FQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWV-SSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLP--FHVGRYLFSK-SFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRK 347
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Celegans
Match: frpr-10 (FMRFamide Peptide Receptor family [Source:UniProtKB/TrEMBL;Acc:O45096])

HSP 1 Score: 68.1662 bits (165), Expect = 1.925e-12
Identity = 64/222 (28.83%), Postives = 103/222 (46.40%), Query Frame = 2 
Query:  569 ARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNK--------YLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLN-LLVDTS-----KAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKC 1192
            A+  S++T V VTV+RFI V FP+KR  + T      +L V+  +S +  +P FF   +  +     +   +N+        YL++      T + LIP  +I+  N+ II+ +R   R    +V  S     K +  E+ +T+   V++ +F I  IP        GIN +  D+            +S +L  +N A N +IYC     FR AAL L+ C
Sbjct:   41 AQAGSVWTYVAVTVDRFIAVCFPIKRRVWSTRSNTITVLFVITFISAIFKLPSFFEVRLDHNGEVEPTELRKNEFYIEFYLFYLYV------TFIQLIPWTLIIFLNAIIIHKVRLAYRAQEAMVHNSGKLNTKREDAERKVTVMATVMTMIFIICNIPP-------GIN-YLVDRYSNPTVYRQRIPLSNVLVCVNSASNMMIYCVFNSRFRRAALKLLGC 248
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Celegans
Match: frpr-6 (FMRFamide Peptide Receptor family [Source:UniProtKB/TrEMBL;Acc:Q8I7K6])

HSP 1 Score: 59.6918 bits (143), Expect = 1.455e-9
Identity = 82/319 (25.71%), Postives = 143/319 (44.83%), Query Frame = 2 
Query:  365 KMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASH------PCFPLSISVRNKYLWINNLIESTIL--SLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGI-NEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTSANDGNTRN-LDHGDSV 1291
            K +  F L+ L++ DI  LL  LP +    L  P + ++YG      W    +   + T F       A+T S+Y +V++TVER+I V  P++   +CT   +  ++  +   S++++ P FF + I         P   +  +  + + +I+  I  +++   L+P +I+ + N  +I  LR   +   L+ TS  K  E++ T+ LLVV+ +F      S+ +     I  ++    +       +   +S IL  I++   F IY F    FR      + C+L    K R NL     S  D N R  L   DS+
Sbjct:   39 KSTVAFLLYSLSICDIFVLLFALPLYSISYL--PIWDNVYG-----AWSMRRMFIAFSTKFFYPLCMTAKTASLYIMVVITVERWIAVCRPLQVHIWCTFKNSVRIVIAIITFSIILNFPKFFEYQIGYSDALGYWPKRGILDAEEHWWYYISYFIIISVIFDYLLPFVIMFIANMKVINELRKSRKERALLTTSLQK--EQNTTVMLLVVTILFGFCHFFSMALKLFESIFKDFLNRHNEYFEVMIE---VSNILIVIHIGTTFFIYYFFSARFRN-----ILCYL---FKKRSNL--PDNSLTDLNKRKLLQKSDSI 335
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Celegans
Match: frpr-8 (FMRFamide Peptide Receptor family [Source:UniProtKB/TrEMBL;Acc:Q20686])

HSP 1 Score: 56.6102 bits (135), Expect = 2.237e-8
Identity = 78/328 (23.78%), Postives = 133/328 (40.55%), Query Frame = 2 
Query:  353 RAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSIS-------VRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLND-------MRKYRDNLVTETTSANDGNTRNLDHGDSVA 1294
            R   + S + YL  L+VFD+I LLSF     + ++  P    +           F       TP+ +  +  A+  S++T V VTV+RF+ V +P+    +CT   A  +L  + V S+L   P F  F++ +  C  L  S        +  Y+    LI    L LIP  ++++ N  ++  +    ++   +   K  ++EKD    L+ ++ +   L     VV  ++ + E   + S           I  +L  +N A N +IY   G  FR   + L+ C           + +Y    +       DG TR      S A
Sbjct:   71 RKQMRSSLNVYLAGLSVFDLI-LLSF-----SALIFSPLQGCVLQGHGDTAVCHFFWRS---TPWTLPISNIAQCGSVWTCVAVTVDRFLAVNYPLHSKIWCTPRRATTILIAITVFSILFKAPMF--FELTNDDCGRLRTSFLRDNKYYKEYYVTFGYLIA---LLLIPWTVMIILNVFVVKAVHKAYKIRRSMQGGKNNQEEKDRRCTLMAIAMVLTFLIFN--VVAAVNNLAETVFEVSL-----GFWSPIGNLLICLNSASNIVIYSLFGARFRQMCV-LMLCGRQSRWMEWLKVGRYPPQSMVSDWDGRDGTTRKTSLDASTA 376
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Celegans
Match: frpr-11 (FMRFamide Peptide Receptor family [Source:UniProtKB/TrEMBL;Acc:Q9GYH2])

HSP 1 Score: 51.6026 bits (122), Expect = 7.043e-7
Identity = 77/318 (24.21%), Postives = 131/318 (41.19%), Query Frame = 2 
Query:  350 RRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFA----ARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFD---IASHPCFPLSISVRNK-YLWINNLIESTIL-SLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKAD-AYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDM----RKYRDNLVTETTSANDGN 1261
            R    K +  F L  L+  D+I L++ +P+F             Y   +  G+ E   +    + F + + +      +    Y IV+++VER+  V  P++   +CT       ++ +  +S+L + P FF F    I     F L+   +N+ Y ++   I + I  +LIP  II V N  +I  LR       L+ T + K  +   T  LLV+ FM+    I   +   +  IN ++ +    +       + IS +L     A  F IY    + +R      V C   D      + R N  T+TT +N  N
Sbjct:   61 RHHMNKNTIGFLLLSLSTIDLIVLITAMPSFGT-----------YKFPFFPGYHEIGSVHTIFSAFCLIYFYPLMCMGKMMGQYIIVLISVERWFAVCRPLQVQIWCTQKNTIRAMTCIIAISILFNAPRFFEFKANLITGVIGFGLAHISKNEWYFYLYYGIRAIIFDALIPFSIIAVTNIQVIQQLRKSNEERKLMTTQQQK--DNKTTTMLLVMIFMY---AICHFLCTSVKFINLFSHNYVQFQFVIFKIIHHISNVLLVFYSASTFFIYLIFSEKYRNVLSTCVTCRNTDELTVSSRGRQN--TKTTRSNSQN 360
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Celegans
Match: frpr-4 (FMRFamide Peptide Receptor family [Source:UniProtKB/TrEMBL;Acc:A0A131MBD2])

HSP 1 Score: 51.2174 bits (121), Expect = 9.718e-7
Identity = 58/218 (26.61%), Postives = 101/218 (46.33%), Query Frame = 2 
Query:  353 RAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIA---SHPCFPLSISVRNKYLWINNLIESTILS----LIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMF 985
            R   K    F L+ L+V DI  L+  LP F ++M     Y  I+     +  V ++   KY+ P  M     A+TCS+Y +V++T+ER+I V  P++   +C    +   ++ +   +++++   FF F+I        F   +    K+ W        I      L+P +I+ V N  II  LR   +   L+   + K  E++ T+ LLV++  F
Sbjct:   35 RKNRKSMVGFLLYSLSVSDIFLLVFALPLF-SIM-----YLPIWTDEQRSFVVAYT--AKYVYPLCMM----AKTCSLYIMVLITIERWIAVCRPLEVQIWCRYTTSSYSIAAIITFAVVLNFARFFEFEIEYIDGLAFFRRDLLDSEKHWWYFMFYFIIISIIFDYLVPFVIMFVANMLIISELRRTKKERSLMTIQQQK--EQNTTVMLLVITIFF 238
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Fly
Match: FMRFaR (gene:FBgn0035385 transcript:FBtr0340706)

HSP 1 Score: 66.2402 bits (160), Expect = 3.058e-11
Identity = 91/332 (27.41%), Postives = 146/332 (43.98%), Query Frame = 2 
Query:  347 LRRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHP---------CFPLSISVRNKYLWINNLIESTIL---SLIPCLIIVVCNSCIIYTL-----RGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTF-RTAALALVKCHLNDMRKYRDNLVTETTSANDGNTRNLDHGDS 1288
            L R   + S ++ L  LA  D + +++ +  F  +  + PY  H +G         ++ +  +I+P        A+T SIY    VT+ER++ V  P+K    CT   AKI   V    SL  ++P F+     ++P         C   S  +R    +IN  I    L    +IP L + + N C+IY       R R RL      S+++K+E  +   LL V  +FF+L    LV+     I+E     +           IS +L  IN ++NF+IY   G+ F R   L   K  L+  R   D +  E++ +N+G+   L+H  S
Sbjct:  138 LSRPQMRSSINYLLTGLARCDTVLIITSILLF-GIPSIYPYTGHFFGY--------YNYVYPFISPAVFPIGMIAQTASIYMTFTVTLERYVAVCHPLKARALCTYGRAKIYFIVCVCFSLAYNMPRFWEVLTVTYPEPGKDVILHCVRPS-RLRRSETYINIYIHWCYLIVNYIIPFLTLAILN-CLIYRQVKRANRERQRL------SRSEKREIGLATMLLCVVIVFFMLNFLPLVL----NISE-----AFYSTIDHKITKISNLLITINSSVNFLIYIIFGEKFKRIFLLIFFKRRLS--RDQPDLIHYESSISNNGDG-TLNHRSS 440
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Fly
Match: FMRFaR (gene:FBgn0035385 transcript:FBtr0332085)

HSP 1 Score: 66.2402 bits (160), Expect = 3.058e-11
Identity = 91/332 (27.41%), Postives = 146/332 (43.98%), Query Frame = 2 
Query:  347 LRRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHP---------CFPLSISVRNKYLWINNLIESTIL---SLIPCLIIVVCNSCIIYTL-----RGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTF-RTAALALVKCHLNDMRKYRDNLVTETTSANDGNTRNLDHGDS 1288
            L R   + S ++ L  LA  D + +++ +  F  +  + PY  H +G         ++ +  +I+P        A+T SIY    VT+ER++ V  P+K    CT   AKI   V    SL  ++P F+     ++P         C   S  +R    +IN  I    L    +IP L + + N C+IY       R R RL      S+++K+E  +   LL V  +FF+L    LV+     I+E     +           IS +L  IN ++NF+IY   G+ F R   L   K  L+  R   D +  E++ +N+G+   L+H  S
Sbjct:  138 LSRPQMRSSINYLLTGLARCDTVLIITSILLF-GIPSIYPYTGHFFGY--------YNYVYPFISPAVFPIGMIAQTASIYMTFTVTLERYVAVCHPLKARALCTYGRAKIYFIVCVCFSLAYNMPRFWEVLTVTYPEPGKDVILHCVRPS-RLRRSETYINIYIHWCYLIVNYIIPFLTLAILN-CLIYRQVKRANRERQRL------SRSEKREIGLATMLLCVVIVFFMLNFLPLVL----NISE-----AFYSTIDHKITKISNLLITINSSVNFLIYIIFGEKFKRIFLLIFFKRRLS--RDQPDLIHYESSISNNGDG-TLNHRSS 440
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Fly
Match: FMRFaR (gene:FBgn0035385 transcript:FBtr0072980)

HSP 1 Score: 66.2402 bits (160), Expect = 3.058e-11
Identity = 91/332 (27.41%), Postives = 146/332 (43.98%), Query Frame = 2 
Query:  347 LRRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHP---------CFPLSISVRNKYLWINNLIESTIL---SLIPCLIIVVCNSCIIYTL-----RGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTF-RTAALALVKCHLNDMRKYRDNLVTETTSANDGNTRNLDHGDS 1288
            L R   + S ++ L  LA  D + +++ +  F  +  + PY  H +G         ++ +  +I+P        A+T SIY    VT+ER++ V  P+K    CT   AKI   V    SL  ++P F+     ++P         C   S  +R    +IN  I    L    +IP L + + N C+IY       R R RL      S+++K+E  +   LL V  +FF+L    LV+     I+E     +           IS +L  IN ++NF+IY   G+ F R   L   K  L+  R   D +  E++ +N+G+   L+H  S
Sbjct:  138 LSRPQMRSSINYLLTGLARCDTVLIITSILLF-GIPSIYPYTGHFFGY--------YNYVYPFISPAVFPIGMIAQTASIYMTFTVTLERYVAVCHPLKARALCTYGRAKIYFIVCVCFSLAYNMPRFWEVLTVTYPEPGKDVILHCVRPS-RLRRSETYINIYIHWCYLIVNYIIPFLTLAILN-CLIYRQVKRANRERQRL------SRSEKREIGLATMLLCVVIVFFMLNFLPLVL----NISE-----AFYSTIDHKITKISNLLITINSSVNFLIYIIFGEKFKRIFLLIFFKRRLS--RDQPDLIHYESSISNNGDG-TLNHRSS 440
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Fly
Match: CNMaR (gene:FBgn0053696 transcript:FBtr0091684)

HSP 1 Score: 58.5362 bits (140), Expect = 7.804e-9
Identity = 52/182 (28.57%), Postives = 78/182 (42.86%), Query Frame = 2 
Query:  350 RRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMG----KYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSI----SVRNKYLWINNLIESTILSLIPCLIIVVCNSC 871
            R    K+SS FYL  LAV D   L                          A W+ F  +      Y   F  FF++ A  CS++ +V  TVERFI V++P+KR   CT+  AKI+L  + +V  L  +P+         P    +I    S   + L + N  ++ ++  +P   I V N+C
Sbjct:   86 RTKLRKLSSSFYLAALAVSDTCFLAGLF----------------------AQWLNFLNVDIYNQNYFCQFFTFFSYLASFCSVWFVVAFTVERFIAVIYPLKRQTMCTVRRAKIVLFCLTLVGCLHCLPYIVIAKPVFMPKLNTTICDLNSEYKEQLALFNYWDTIVVYAVPFTTIAVLNTC 245
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Zebrafish
Match: gpr142 (G protein-coupled receptor 142 [Source:ZFIN;Acc:ZDB-GENE-130603-30])

HSP 1 Score: 76.6406 bits (187), Expect = 8.226e-15
Identity = 64/216 (29.63%), Postives = 105/216 (48.61%), Query Frame = 2 
Query:  563 FAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDI--ASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAK----KQEKDITIRLLVVSFMFFILTIP-------SLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTA 1171
            F+A   SI+  V +TV+R++ +  P+   Q      A+ +++V+  ++L   +P+F+  D+   SH    L  ++    +W +     TI+  +PC I +V NS II  LR R R  +  D S  +     +    T  LL V+ +F +L  P        L V  +H  N+W   + HL      AY ++ +L  +N A+NF +YCF  K FR A
Sbjct:  111 FSANHASIWATVPLTVDRYVALCHPLLHRQISYPARARRIIAVVLTLALASGVPFFWWSDMWRVSHEPNNLDTAL----IWTH----VTIIYFLPCCIFLVLNSLIILRLRKRQRQQMCQDESGQQLAVPSRLGKTTAMLLAVTSVFAVLWAPRTGVVLYHLYVTSVH--NDW---RVHL------AYDLANMLAMLNTAVNFFLYCFVSKPFRAA 307
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Zebrafish
Match: trhr2 (thyrotropin releasing hormone receptor 2 [Source:ZFIN;Acc:ZDB-GENE-050419-193])

HSP 1 Score: 54.299 bits (129), Expect = 2.263e-7
Identity = 85/323 (26.32%), Postives = 136/323 (42.11%), Query Frame = 2 
Query:  365 KMSSHFYLWWLAVFDIISLLSF-LPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSIS---VRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGR-LRLNLL---------------------VDTSKAKKQ---------EKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFA-----INLAINFIIYCFTGKTFRTAALALVKCHLNDMRK 1213
            +  ++ YL  LAV D++ L++  LP     ++    Y H       AG +        IT F+ +    A +CSI      TVER+I +  PM+    CT+  AK +++V++V + +  + W F  DI  +P   +       R+ YL I  LI+ TI  +IP L+ +      +Y L  R L LN L                      D  KA +Q          K +T  L VV  +F +L +P   ++ I+         S +     D++    ILF       N AIN ++Y    + FR+A   L +C   D+ +
Sbjct:   64 RTPTNCYLVSLAVADLMVLVAAGLPNISESLMATWVYGH-------AGCLG-------ITYFQ-YLGINASSCSITAF---TVERYIAICHPMRAQTVCTVSRAKRIIAVVWVFTCVYCMLWLFLVDIQVNPDGRVQCGYRVSRDLYLPI-YLIDFTIFYVIPLLLAIA-----LYGLIARILYLNPLPHPPDSGTVIAPTLRRSCKEPADGGKAIRQGRPKSALSSRKQVTKMLAVVVVLFALLWMPYRTLVLIN---------SFVSTPYLDSW---FILFCRTCIYANSAINPVVYNLMSQKFRSAFRGLYRCRREDLHQ 350
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Zebrafish
Match: trhr2 (thyrotropin releasing hormone receptor 2 [Source:ZFIN;Acc:ZDB-GENE-050419-193])

HSP 1 Score: 53.9138 bits (128), Expect = 2.510e-7
Identity = 85/323 (26.32%), Postives = 136/323 (42.11%), Query Frame = 2 
Query:  365 KMSSHFYLWWLAVFDIISLLSF-LPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSIS---VRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGR-LRLNLL---------------------VDTSKAKKQ---------EKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFA-----INLAINFIIYCFTGKTFRTAALALVKCHLNDMRK 1213
            +  ++ YL  LAV D++ L++  LP     ++    Y H       AG +        IT F+ +    A +CSI      TVER+I +  PM+    CT+  AK +++V++V + +  + W F  DI  +P   +       R+ YL I  LI+ TI  +IP L+ +      +Y L  R L LN L                      D  KA +Q          K +T  L VV  +F +L +P   ++ I+         S +     D++    ILF       N AIN ++Y    + FR+A   L +C   D+ +
Sbjct:   63 RTPTNCYLVSLAVADLMVLVAAGLPNISESLMATWVYGH-------AGCLG-------ITYFQ-YLGINASSCSITAF---TVERYIAICHPMRAQTVCTVSRAKRIIAVVWVFTCVYCMLWLFLVDIQVNPDGRVQCGYRVSRDLYLPI-YLIDFTIFYVIPLLLAIA-----LYGLIARILYLNPLPHPPDSGTVIAPTLRRSCKEPADGGKAIRQGRPKSALSSRKQVTKMLAVVVVLFALLWMPYRTLVLIN---------SFVSTPYLDSW---FILFCRTCIYANSAINPVVYNLMSQKFRSAFRGLYRCRREDLHQ 349
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Zebrafish
Match: trhr2 (thyrotropin releasing hormone receptor 2 [Source:ZFIN;Acc:ZDB-GENE-050419-193])

HSP 1 Score: 53.9138 bits (128), Expect = 2.812e-7
Identity = 82/323 (25.39%), Postives = 133/323 (41.18%), Query Frame = 2 
Query:  365 KMSSHFYLWWLAVFDIISLLSF-LPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSIS---VRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGR-LRLNLL---------------------VDTSKAKKQ---------EKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFA-----INLAINFIIYCFTGKTFRTAALALVKCHLNDMRK 1213
            +  ++ YL  LAV D++ L++  LP     ++              A WV +   G     +  +    A +CSI      TVER+I +  PM+    CT+  AK +++V++V + +  + W F  DI  +P   +       R+ YL I  LI+ TI  +IP L+ +      +Y L  R L LN L                      D  KA +Q          K +T  L VV  +F +L +P   ++ I+         S +     D++    ILF       N AIN ++Y    + FR+A   L +C   D+ +
Sbjct:   63 RTPTNCYLVSLAVADLMVLVAAGLPNISESLM--------------ASWV-YGHAGCLGITYFQYLGINASSCSITAF---TVERYIAICHPMRAQTVCTVSRAKRIIAVVWVFTCVYCMLWLFLVDIQVNPDGRVQCGYRVSRDLYLPI-YLIDFTIFYVIPLLLAIA-----LYGLIARILYLNPLPHPPDSGTVIAPTLRRSCKEPADGGKAIRQGRPKSALSSRKQVTKMLAVVVVLFALLWMPYRTLVLIN---------SFVSTPYLDSW---FILFCRTCIYANSAINPVVYNLMSQKFRSAFRGLYRCRREDVHQ 349
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Xenopus
Match: GPR142 (G protein-coupled receptor 142 [Source:HGNC Symbol;Acc:HGNC:20088])

HSP 1 Score: 73.1738 bits (178), Expect = 1.489e-13
Identity = 60/223 (26.91%), Postives = 108/223 (48.43%), Query Frame = 2 
Query:  563 FAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIH----GIN-EWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALV----KCHLND 1204
            F++   SI+  VI+TV+R++ + +P++   F      + ++  +F+ S +  +P+++  D+   P  P  + +  K+          I+  IPC I ++ NS IIY LR R        + K + +    T  LL ++ +F +L  P  +VI IH     +N +W   K HL      A  I  +L  +N A+NF +YCF  + FR     ++    +CH+ +
Sbjct:  113 FSSNHASIWVTVILTVDRYVALCYPLQYRSFSYPERTRRVIVFVFLSSFVTGVPFYWWSDVWRDPRTPGLLDLILKW------THCFIIYFIPCTIFLITNSVIIYRLRKR------TGSKKCQLRNGKTTAILLGITSVFAVLWAPRTIVIIIHMYVSSVNKDW---KVHL------AMDIGNMLALLNTAVNFFLYCFVNRRFRDTVREILGIFRRCHMKE 314
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Xenopus
Match: gpr139 (G protein-coupled receptor 139 [Source:NCBI gene;Acc:100493863])

HSP 1 Score: 55.0694 bits (131), Expect = 1.333e-7
Identity = 67/238 (28.15%), Postives = 109/238 (45.80%), Query Frame = 2 
Query:  563 FAARTCSIYTIVIVTVERFIMVLFPMK-RTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGI-----NEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAAL----ALVKCHLNDMRKYRDNLVTETTS 1246
            F++   SI+  V +T++R+I V  P+   T        K+++SV ++   L SIP+++  +I        S SV +  +WI+       + L+PC I  V NS I+Y L+ +    L     +     K   I L  ++ +F IL  P +++I  H       N W     H+    A+  A+      +N AINF +YCF  K FRT A     A  KC    ++ Y +   + T+S
Sbjct:  104 FSSIHTSIWITVPLTIDRYIAVCHPLTYHTVSFPARTRKVIVSV-YITCFLTSIPYYWWPNIWIEDY--TSTSVHHILIWIHCFT----VYLVPCSIFFVLNSIIVYKLQRKSNFRL-----RGYSTGKTTAI-LFSITSIFAILWAPRIIMILYHLYVSPIHNSWL---VHIVTDIANMLAL------LNTAINFFLYCFISKRFRTMAAGTLKAFFKCQKQPVQFYTNYNFSITSS 319
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Xenopus
Match: epx (eosinophil peroxidase [Source:Xenbase;Acc:XB-GENE-6039946])

HSP 1 Score: 50.8322 bits (120), Expect = 3.011e-6
Identity = 68/293 (23.21%), Postives = 119/293 (40.61%), Query Frame = 2 
Query:  554 FFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSIS---VRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRL---------------------------------RLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAI---SIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTSANDGNTRNLDHGDSVANRESFQQ 1315
            +F +     S  +I   TVER+I +  PM+    CT+  AK +++++++ + +  + WFF  DI  +    +       RN YL I  L +  I  + P L+     + I+Y L GR+                                 + +  + T  A    K +T  L VV  +F +L +P   ++ ++       DK +L     D + +    I ++A N AIN +IY    + FRTA   L KC     R+      T  +   DG    ++ G     ++S ++
Sbjct:  106 YFQYLGINASSCSITAFTVERYIAICHPMRAQTVCTVSRAKRIIAIVWIFTSIYCMFWFFLVDIHVNKSQQVECGYKVSRNLYLPI-YLADFAIFYVTPLLV-----ATILYGLIGRILFLSPIPQHPESTTERWREKSSKEKTESETEGNKPSNRLKTKGALSSRKQVTKMLAVVVVLFALLWMPYRTLVLVNSFM----DKPYL-----DPWFLLFCRICVYA-NSAINPVIYNLMSQKFRTAFKRLCKCGHEAQRRSIYMTTTSYSMVKDG----VNTGGEKKEKQSLEK 378
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Mouse
Match: Gpr139 (G protein-coupled receptor 139 [Source:MGI Symbol;Acc:MGI:2685341])

HSP 1 Score: 63.1586 bits (152), Expect = 2.462e-10
Identity = 69/238 (28.99%), Postives = 113/238 (47.48%), Query Frame = 2 
Query:  563 FAARTCSIYTIVIVTVERFIMVLFPMK-RTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGI-----NEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAAL----ALVKCHLNDMRKYRDNLVTETTS 1246
            F++   SI+  V +TV+R+I V  P+K  T        K++LSV ++   L SIP+++  +I +     +S S+ +  +WI+       + L+PC I  + NS I+Y LR +    L     +     K   I L  ++ +F  L  P +++I  H       N W     H+    A+  A+      +N AINF +YCF  K FRT A     AL KC    ++ Y ++  + T+S
Sbjct:  101 FSSIHTSIWITVPLTVDRYIAVCHPLKYHTVSYPARTRKVILSV-YITCFLTSIPYYWWPNIWTEDY--ISTSMHHVLVWIHCFT----VYLVPCSIFFILNSIIVYKLRRKSNFRL-----RGYSTGKTTAI-LFTITSIFATLWAPRIIMILYHLYGAPIQNPWL---VHIMLDVANMLAL------LNTAINFFLYCFISKRFRTMAAATLKALFKCQKQPVQFYTNHNFSITSS 316
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Mouse
Match: Gpr142 (G protein-coupled receptor 142 [Source:MGI Symbol;Acc:MGI:2668437])

HSP 1 Score: 60.4622 bits (145), Expect = 1.988e-9
Identity = 61/210 (29.05%), Postives = 98/210 (46.67%), Query Frame = 2 
Query:  557 FTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYL-WINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGI-----NEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRT 1168
              FAA   S++  V+ TV+R+  +  P++     +       ++ +  V+LL  IP+++  D+      P   S  +K L W + LI    +  IPC + +V NS II  LR R +  L    SK+       T  LL V+ +F +L  P ++V+  H        +W   + HL      A  I+ +L  +N  +NF +YCF  KTFR 
Sbjct:  144 LEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPP---STMDKLLKWAHCLI----VYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKS-------TAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDW---RVHL------ALDIANMLAMLNTEVNFGLYCFISKTFRA 330
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Mouse
Match: Gpr142 (G protein-coupled receptor 142 [Source:MGI Symbol;Acc:MGI:2668437])

HSP 1 Score: 60.4622 bits (145), Expect = 2.093e-9
Identity = 61/210 (29.05%), Postives = 98/210 (46.67%), Query Frame = 2 
Query:  557 FTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYL-WINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGI-----NEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRT 1168
              FAA   S++  V+ TV+R+  +  P++     +       ++ +  V+LL  IP+++  D+      P   S  +K L W + LI    +  IPC + +V NS II  LR R +  L    SK+       T  LL V+ +F +L  P ++V+  H        +W   + HL      A  I+ +L  +N  +NF +YCF  KTFR 
Sbjct:  150 LEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPP---STMDKLLKWAHCLI----VYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKS-------TAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDW---RVHL------ALDIANMLAMLNTEVNFGLYCFISKTFRA 336
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9VZW5|FMAR_DROME (FMRFamide receptor OS=Drosophila melanogaster OX=7227 GN=FMRFaR PE=2 SV=1)

HSP 1 Score: 66.2402 bits (160), Expect = 3.066e-10
Identity = 91/332 (27.41%), Postives = 146/332 (43.98%), Query Frame = 2 
Query:  347 LRRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHP---------CFPLSISVRNKYLWINNLIESTIL---SLIPCLIIVVCNSCIIYTL-----RGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTF-RTAALALVKCHLNDMRKYRDNLVTETTSANDGNTRNLDHGDS 1288
            L R   + S ++ L  LA  D + +++ +  F  +  + PY  H +G         ++ +  +I+P        A+T SIY    VT+ER++ V  P+K    CT   AKI   V    SL  ++P F+     ++P         C   S  +R    +IN  I    L    +IP L + + N C+IY       R R RL      S+++K+E  +   LL V  +FF+L    LV+     I+E     +           IS +L  IN ++NF+IY   G+ F R   L   K  L+  R   D +  E++ +N+G+   L+H  S
Sbjct:  138 LSRPQMRSSINYLLTGLARCDTVLIITSILLF-GIPSIYPYTGHFFGY--------YNYVYPFISPAVFPIGMIAQTASIYMTFTVTLERYVAVCHPLKARALCTYGRAKIYFIVCVCFSLAYNMPRFWEVLTVTYPEPGKDVILHCVRPS-RLRRSETYINIYIHWCYLIVNYIIPFLTLAILN-CLIYRQVKRANRERQRL------SRSEKREIGLATMLLCVVIVFFMLNFLPLVL----NISE-----AFYSTIDHKITKISNLLITINSSVNFLIYIIFGEKFKRIFLLIFFKRRLS--RDQPDLIHYESSISNNGDG-TLNHRSS 440
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6DWJ6|GP139_HUMAN (Probable G-protein coupled receptor 139 OS=Homo sapiens OX=9606 GN=GPR139 PE=2 SV=1)

HSP 1 Score: 63.5438 bits (153), Expect = 1.266e-9
Identity = 65/235 (27.66%), Postives = 113/235 (48.09%), Query Frame = 2 
Query:  563 FAARTCSIYTIVIVTVERFIMVLFPMK-RTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDK--SHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALV----KCHLNDMRKYRDNLVTETTS 1246
            F++   SI+  V +T++R+I V  P+K  T        K+++SV ++   L SIP+++  +I +     +S SV +  +WI+       + L+PC I  + NS I+Y LR +    L     +     K   I L  ++ +F  L  P +++I  H       ++   H+    A+  A+      +N AINF +YCF  K FRT A A +    KC    ++ Y ++  + T+S
Sbjct:  109 FSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSV-YITCFLTSIPYYWWPNIWTEDY--ISTSVHHVLIWIHCFT----VYLVPCSIFFILNSIIVYKLRRKSNFRL-----RGYSTGKTTAI-LFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLAL------LNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSS 324
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. UniProt/SwissProt
Match: sp|P0C0W8|GP139_RAT (Probable G-protein coupled receptor 139 OS=Rattus norvegicus OX=10116 GN=Gpr139 PE=2 SV=1)

HSP 1 Score: 63.1586 bits (152), Expect = 1.588e-9
Identity = 69/240 (28.75%), Postives = 114/240 (47.50%), Query Frame = 2 
Query:  563 FAARTCSIYTIVIVTVERFIMVLFPMK-RTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAK-ADAYAISIILFAINL------AINFIIYCFTGKTFRTAAL----ALVKCHLNDMRKYRDNLVTETTS 1246
            F++   SI+  V +TV+R+I V  P+K  T        K++LSV ++   L SIP+++  +I +     +S S+ +  +WI+       + L+PC I  + NS I+Y LR +    L     +     K   I L  ++ +F  L  P +++I             HL GA   + + + I+L   N+      AINF +YCF  K FRT A     AL KC    ++ Y ++  + T+S
Sbjct:  101 FSSIHTSIWITVPLTVDRYIAVCHPLKYHTVSYPARTRKVILSV-YITCFLTSIPYYWWPNIWTEDY--ISTSMHHVLVWIHCFT----VYLVPCSIFFILNSIIVYKLRRKSNFRL-----RGYSTGKTTAI-LFTITSIFATLWAPRIIMI-----------LYHLYGAPIQNPWLVHIMLDVANMLALLNTAINFFLYCFISKRFRTMAAATLKALFKCQKQPVQFYTNHNFSITSS 316
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q80UC8|GP139_MOUSE (Probable G-protein coupled receptor 139 OS=Mus musculus OX=10090 GN=Gpr139 PE=2 SV=2)

HSP 1 Score: 63.1586 bits (152), Expect = 1.722e-9
Identity = 69/238 (28.99%), Postives = 113/238 (47.48%), Query Frame = 2 
Query:  563 FAARTCSIYTIVIVTVERFIMVLFPMK-RTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGI-----NEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAAL----ALVKCHLNDMRKYRDNLVTETTS 1246
            F++   SI+  V +TV+R+I V  P+K  T        K++LSV ++   L SIP+++  +I +     +S S+ +  +WI+       + L+PC I  + NS I+Y LR +    L     +     K   I L  ++ +F  L  P +++I  H       N W     H+    A+  A+      +N AINF +YCF  K FRT A     AL KC    ++ Y ++  + T+S
Sbjct:  101 FSSIHTSIWITVPLTVDRYIAVCHPLKYHTVSYPARTRKVILSV-YITCFLTSIPYYWWPNIWTEDY--ISTSMHHVLVWIHCFT----VYLVPCSIFFILNSIIVYKLRRKSNFRL-----RGYSTGKTTAI-LFTITSIFATLWAPRIIMILYHLYGAPIQNPWL---VHIMLDVANMLAL------LNTAINFFLYCFISKRFRTMAAATLKALFKCQKQPVQFYTNHNFSITSS 316
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q7TQN9|GP142_MOUSE (Probable G-protein coupled receptor 142 OS=Mus musculus OX=10090 GN=Gpr142 PE=2 SV=1)

HSP 1 Score: 60.4622 bits (145), Expect = 1.390e-8
Identity = 61/210 (29.05%), Postives = 98/210 (46.67%), Query Frame = 2 
Query:  557 FTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYL-WINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGI-----NEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRT 1168
              FAA   S++  V+ TV+R+  +  P++     +       ++ +  V+LL  IP+++  D+      P   S  +K L W + LI    +  IPC + +V NS II  LR R +  L    SK+       T  LL V+ +F +L  P ++V+  H        +W   + HL      A  I+ +L  +N  +NF +YCF  KTFR 
Sbjct:  144 LEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPP---STMDKLLKWAHCLI----VYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKS-------TAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDW---RVHL------ALDIANMLAMLNTEVNFGLYCFISKTFRA 330
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. TrEMBL
Match: A0A5J4NPF4 (G_PROTEIN_RECEP_F1_2 domain-containing protein OS=Paragonimus westermani OX=34504 GN=DEA37_0003125 PE=3 SV=1)

HSP 1 Score: 184.496 bits (467), Expect = 9.179e-50
Identity = 114/365 (31.23%), Postives = 193/365 (52.88%), Query Frame = 2 
Query:  362 TKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFD--------IASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGR----LRLN---------------------------LLVDTSK-AKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTSANDGNTRNLDHGDSVANRESFQQKRSLLNS 1336
            T++S H YL  LAVFD +SL+ ++ +FW +++L PY Y   G       ++   M +     R++  F  R  S++T+V++++ERF++++ P++  +     +A I + +  +++ L S PW FSF          A+ P       V N+  + + LIE T+++++P ++++V N+ I  TL  R    LR+N                           L+ +  + A++ E+ +TIRL +V+ +F +L+ PS++++ +H   E+   K+HLRG  ADA+ IS +LFA NLAINFIIYC TG+TFR A  AL+ C    +++ R  L T      D N      GD  A +   +   S +NS
Sbjct:   17 TRISGHIYLACLAVFDTLSLVFYMMSFWNILVLIPYLYQ-RGNYDTVNLIQRHFMSQGRCELRVYLNFLFRMLSVWTVVVLSMERFLLIVSPLRFYKVLRPRLAWITMGLCALIAGLTSTPWLFSFSYVEKYQCITATSPQVSYLRCVPNEIFFASRLIECTLITIVPAVLLLVANTQIAITLSQRRKIWLRMNPPEKTDSKAVVQPDGSSAQIHALEPDSLMAEGHRTAQRSERRLTIRLFMVAVVFLVLSTPSMILVAVHTYYEYQHKKNHLRGPLADAHFISQLLFATNLAINFIIYCVTGRTFRRALWALITCRWRLVKRLRSVLETGIEDQTDENELTYRDGDQPAKKTHSKSPMSDVNS 380
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. TrEMBL
Match: A0A267EIX8 (G_PROTEIN_RECEP_F1_2 domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig001026g1 PE=3 SV=1)

HSP 1 Score: 171.4 bits (433), Expect = 1.200e-44
Identity = 109/333 (32.73%), Postives = 185/333 (55.56%), Query Frame = 2 
Query:  347 LRRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMK-RTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIAS--HPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTSANDGNTRNLDHGDSVANRE-SFQQKRSLLN 1333
            L+ +AT++SSHFYL  L++ D ++L+S + + W  +++  YYY +YG    A W+        ++ FR++ +F  R  S++T+VI++VER I V  P++  T+ CT+      +  + +++   SI   F F+ +     C P      N + +I N++ + + S++P ++I + NS ++  LR R R +  +D  K  +QE  IT RLLVVS  F  LT+P  +   I+   E    ++H  G  AD + +S +LF  N A NF +YC TG+ FR AA+AL+ CHL+ MR+ R  L   + SA +  +  L    S+   + + +Q  +LL+
Sbjct:   74 LKESATRVSSHFYLCCLSILDSLTLVSIVFSIWLAVIMPGYYYVLYG--QVAAWLRSVTSNCQVSQFRVYISFYCRMVSVWTVVILSVERCISVSSPLRWGTRLCTVRNGVWAIGGLVLLAAPFSIYAVFGFEYSEKYRTCRP------NDHFFIGNILSNVLFSIVPWIVICISNSVLVLVLRKRNRRSSQMD-QKTLRQENSITTRLLVVSVTFLFLTLPLAITSAINSYYELQDLRTHKTGIVADLWMVSFVLFTANFASNFWLYCLTGRNFRRAAVALLTCHLDSMRRLRRRLDRGSDSAAEPPSSKLTAVSSLTGHDVAAKQSAALLS 397
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. TrEMBL
Match: A0A1I8I6Q0 (G_PROTEIN_RECEP_F1_2 domain-containing protein OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 169.088 bits (427), Expect = 3.496e-44
Identity = 106/322 (32.92%), Postives = 178/322 (55.28%), Query Frame = 2 
Query:  347 LRRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMK-RTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIAS--HPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTSANDGNTRNLDHGDSVANRE 1303
            L+ +AT++SSHFYL  L++ D ++L+S + + W  +++  YYY +YG    A W+        ++ FR++ +F  R  S++T+VI++VER I V  P++  T+ CT+      +  + +++   SI   F F+ +     C P      N + +I N++ + + S++P ++I + NS ++  LR R R +  +D  K  +QE  IT RLLVVS  F  LT+P  +   I+   E    ++H  G  AD + +S +LF  N A NF +YC TG+ FR AA+AL+ CHL+ MR+ R  L   + SA +  +  L    S+   +
Sbjct:   58 LKESATRVSSHFYLCCLSILDSLTLVSIVFSIWLAVIMPGYYYVLYG--QVAAWLRSVTSNCQVSQFRVYISFYCRMVSVWTVVILSVERCISVSSPLRWGTRLCTVRNGVWAIGGLVLLAAPFSIYAVFGFEYSEKYRTCRP------NDHFFIGNILSNVLFSIVPWIVICISNSVLVLVLRKRNRRSSQMD-QKTLRQENSITTRLLVVSVTFLFLTLPLAITSAINSYYELQDLRTHKTGIVADLWMVSFVLFTANFASNFWLYCLTGRNFRRAAVALLTCHLDSMRRLRRRLDRGSDSAAEPPSSKLTAVSSLTGHD 370
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. TrEMBL
Match: A0A267DP97 (G_PROTEIN_RECEP_F1_2 domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig031474g1 PE=3 SV=1)

HSP 1 Score: 163.696 bits (413), Expect = 9.342e-42
Identity = 107/333 (32.13%), Postives = 183/333 (54.95%), Query Frame = 2 
Query:  347 LRRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMK-RTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIAS--HPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTSANDGNTRNLDHGDSVANRE-SFQQKRSLLN 1333
            L+ +AT++SSHFYL  L++ D ++L+S + + W  +++  YYY +YG    A W+        ++ FR++ +F  R  S++T+VI++VER I V  P++  T+ CT+      +  + +++   SI   F F+ +     C P      N + +I N++ + + S++P ++I + N  ++  LR R R +  +D  K  +QE  IT RLLVVS  F  LT+P  +   I+   E    ++H  G  AD + +S +LF  N A NF +YC TG+ FR AA+AL+  HL+ MR+ R  L   + SA +  +  L    S+   + + +Q  +LL+
Sbjct:   69 LKESATRVSSHFYLCCLSILDSLTLVSIVFSIWLAVIMPGYYYVLYG--QVAAWLRSVTSNCQVSQFRVYISFYCRMVSVWTVVILSVERCISVSSPLRWGTRLCTVRNGVWAIGGLVLLAAPFSIYAVFGFEYSEKYRTCRP------NDHFFIGNILSNVLFSIVPWIVICISNLVLVLVLRKRNRRSSQMD-QKTLRQENSITTRLLVVSVTFLFLTLPLAITSAINSYYELQDLRTHKTGIVADLWMVSFVLFTANFASNFWLYCLTGRNFRRAAVALLTWHLDSMRRLRRRLDRGSDSAAEPPSSKLTAVSSLTGHDVAAKQSAALLS 392
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. TrEMBL
Match: A0A267FGB4 (G_PROTEIN_RECEP_F1_2 domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig018741g1 PE=3 SV=1)

HSP 1 Score: 162.925 bits (411), Expect = 2.361e-41
Identity = 125/390 (32.05%), Postives = 210/390 (53.85%), Query Frame = 2 
Query:  155 LFLKKRSKITMSTSLATINCLDPKQVFIEVFTPIPNYATTIFGVYFLPXXXXXXXXXXXXXXXXLRRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMK-RTQFCTIYVAKILLSVMFVVSLLISIPWFFSFD----IASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTS-KAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNL-VTETTSANDGNTRNLDHGDSVANRE 1303
            L L K +++  S + +  N   P  +FI V  P+ N     F   F+PI+   G+IGN ++ I+L+ +A+++SSHFYL  LAV D ++L+S + + W  ++++ YYY + G      WV  +    + T FR++ +F  R  S++ +V++++ER I VL P+K  T+ CT+      +  + +VS L++I     F+       H C P      N + +I  L    +LS++P +II + N  ++  LR R R       S + ++QE  IT+RLL VS  F + T+P  V+  IH  +E      H  G  A+ + ++  +F  N   NF++YCFTG+ FR AA AL+ C +  M++ RD L  + + +A+ G T +   G +V+  E
Sbjct:    6 LLLHKMNQLANSGNGSGGNATAPP-IFISV--PVGNVGMQTFCAVFIPIVCGLGIIGNSLAFILLKESASRVSSHFYLCCLAVADSVTLVSIMMSIWLGVIMQGYYY-VIGQFTADNWVRVATGICWFTQFRVYLSFLCRMVSVWLVVVLSIERCISVLSPLKWGTRLCTVRNGVKAVVALVLVSSLLNIYVIIGFERKQVGKQHRCVP------NDFFFIGRLAGKAVLSVVPWIIICIANGLLVAVLRRRNRRATSGGLSNRQERQEMSITVRLLAVSVAFLLFTLPITVMSAIHSYHEIIDSTEHKGGVLANLWLLAFAMFTCNFGCNFLLYCFTGQNFRRAAAALLACRVERMKRLRDRLDRSGSQTASGGGTSSGVAGVTVSGSE 385
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Cavefish
Match: gpr142 (probable G-protein coupled receptor 142 [Source:NCBI gene;Acc:103030394])

HSP 1 Score: 63.5438 bits (153), Expect = 1.245e-10
Identity = 69/262 (26.34%), Postives = 121/262 (46.18%), Query Frame = 2 
Query:  563 FAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDI--ASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKK----QEKDITIRLLVVSFMFFILTIPSLVVIGIHGI-----NEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTA---ALALVKCHLNDMRKYRDNLVTETTSANDGNTRNLDHGDSVANRES 1306
            FAA   SI+  + +TV+R++ +  P+   Q      A+ ++SV+  ++L   +P+F+  D+   S P      S+ +  +W +     TI+  +PC + +V NS I   L+ R R     + S+ ++    +    T  LL V+ +F +L  P   V+  H        +W   + HL      AY ++ +L  +N A+NF +YCF  K FR A    L L    L+  R +         S N  N+ +L  G   ++R++
Sbjct:  113 FAANHASIWATIPLTVDRYVALCHPLLHRQISYPARARRIISVVLTLALASGVPFFWWSDVWRVSRP----PDSLDSALIWTH----VTIIYFLPCSVFLVLNSLIFLRLQRRQREQRCQEESRQQRTVAGRLGKTTAMLLAVTSVFTVLWAPRTAVVLYHLYVSSVHRDW---RVHL------AYDLANMLAMLNTAVNFFLYCFVSKPFRGAVRDVLLLRGAPLHPPRSFNH----RHASTNISNS-SLSSGTKRSHRDA 352
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Cavefish
Match: agtr1b (type-1 angiotensin II receptor A-like [Source:NCBI gene;Acc:103027843])

HSP 1 Score: 56.225 bits (134), Expect = 3.593e-8
Identity = 70/277 (25.27%), Postives = 122/277 (44.04%), Query Frame = 2 
Query:  506 WVEFSLMGKYITPFRMFFTFAART-------CSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIA------SHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFM-FFILTIPSLVV--IGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTSANDGNTRNLDHGDS 1288
            W  F+  G Y  PF  F   A+          SI+ +  ++V+R++ ++ PM+  Q  T+  A+I   +++  + L+S P   S +I       S  C  L  + +   L   ++++S +  L+P LII+ C     Y L GR  L       K  +  +D  +R+L  + + FFI   P  V   + +  + E      H+      A   SI L   N  +N I+Y F G  FR   L L++C     +  R +  T+ T+ ++  ++ L+   S
Sbjct:   84 WATFTATG-YHWPFGSFLCKASAGLVIFNLYTSIFFLTALSVDRYLAIVHPMRSRQRRTLLYARITCVLIWAFAFLLSAPTALSREIHVIENHLSTTCGVLHSNDQIPLLVSLSILKSVLGFLVPFLIIITC-----YCLMGRSLLGSRGLLRKNSRSREDEILRMLAAAVLAFFICWAPHQVFHFMDLLAMLEVV-TSCHVLDIIDTAMPFSICLAYFNSCVNPILYGFVGHNFRKNLLRLLRCRPATAQG-RPSFRTKMTNLSNRASQMLNLSGS 352
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000045631.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000885.1:41322:45262:1 gene:ENSAMXG00000036193.1 transcript:ENSAMXT00000045631.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 53.5286 bits (127), Expect = 2.097e-7
Identity = 63/248 (25.40%), Postives = 112/248 (45.16%), Query Frame = 2 
Query:  521 LMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTSANDGNT 1264
            ++G ++  FR F        SI+ +VI+TV+R ++V+FP+      TI  A  ++ V ++VS ++S P     DI      P +  V +++++         L  IP LIIV+C   I+  L+         + +K+KK  K +T   L+VSF+   L   +   I I+G     G    +    + A  ++  L   N  +N  +Y F GK F+    A++    N + +   + +     +  G T
Sbjct:  134 IIGSFMCKFRSFMLSLNWYSSIFLLVIITVDRCVLVMFPVWAHNQRTIRKASGIIMVAWIVSAVLSTPMIIFRDIQ-----PNAAVVTSRFIF---------LFAIPYLIIVICYVIIMRKLKTN-------EVAKSKKPLKIMT--ALIVSFLICWLPYHTFSFIRING-----GISKKIL---SPAINLTFTLANSNSCLNPFLYAFMGKDFKKQCFAILSKMENAIEEDGRSTIRGVAVSTSGET 350
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000048391.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000062.1:933081:938266:-1 gene:ENSAMXG00000037742.1 transcript:ENSAMXT00000048391.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 52.373 bits (124), Expect = 5.074e-7
Identity = 62/230 (26.96%), Postives = 106/230 (46.09%), Query Frame = 2 
Query:  521 LMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASH------PCFPLSISVRNKYLWINN-----LIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAAL 1177
            + G ++  F  F  F     SI+ +VI++V+R + V+FP+      TI  A +++S+++++S  IS P F    +  H       CF       N Y    +     +       L+P LII+ C   II     +L++N    ++K KK  K +T   L+V+F  F+  IP   ++ +  +N    D S L   +     I + L + N  +N  +Y F G+T R + L
Sbjct:   97 IFGLFMCKFISFIMFLNMFSSIFLLVIISVDRCVAVIFPVWAQNRRTIRKASVIVSLVWIISAGISTPSFTFRTVQPHYVKQTKTCF-------NDYKHDQDHVIVVVFRFVFGFLMPFLIIIACYVVIIR----KLKIN---QSAKTKKPFKIMTA--LIVTF--FLCWIP-FHIVALMELNHEKYDGSFLHVGQV----IGVTLASANSCLNPFLYAFMGRTLRGSVL 303
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Cavefish
Match: agtr2 (type-2 angiotensin II receptor-like [Source:NCBI gene;Acc:103035052])

HSP 1 Score: 52.373 bits (124), Expect = 5.950e-7
Identity = 76/307 (24.76%), Postives = 136/307 (44.30%), Query Frame = 2 
Query:  350 RRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSIS----VRNKYLW--INNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRG--AKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTS 1246
            + ++ +  ++ YL  LA  D++  LS LP FWAV       Y+  G  +  G +   L G  +T       +A    S++ I  ++V+R+  +++P+     C    A+ +  V+++V++L ++P     DI  HP   L+++    +    LW  +  L ++T+  L+P +++  C     Y+  GR  L    D  +  +   D  +RL++   + F L   +  V+   G     G     R   A      IS+ L   N AIN  +YCF G  FR     L       + + RD++ T  +S
Sbjct:   62 QSSSRRTVANTYLVNLAASDLL-FLSSLP-FWAV-------YYSMGYDWVFGRLACKLCGALLT----INVYA----SVFFITCMSVDRYRAIVYPLSTRSVCH---ARTISVVIWLVAVLSTVPTLAFRDI--HPLSQLNVTACVMIYPNSLWHPMLTLAKNTLGFLMPFVVMATC-----YSRIGR-HLLTTPDHLEQAQNRIDRVLRLVIAVVLAFFLCWCTFHVLTFLGALRDLGVNFSCRTDLAVGALLPISLCLGFSNSAINPFLYCFVGNHFREQLCRLYDEKAPRLSQKRDSISTRLSS 340
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Nematostella
Match: EDO48261 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJG8])

HSP 1 Score: 53.9138 bits (128), Expect = 5.207e-8
Identity = 78/314 (24.84%), Postives = 125/314 (39.81%), Query Frame = 2 
Query:  395 LAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLM-GKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWF-----------------------FSFDIASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTSANDGNT 1264
            LA+ D++ L+ F PTF    + +  Y H  G+   AG V  SL+ G+        F +     S   +V + +ERF  V  P        + +    L ++ VV  L +I W                        +SF + S  CF                    +L +IP   + V  S +I+ L  R  +  + +    +++ K  T  ++VVSF++ +  IP L +  I          + +RG  A  Y  S+ +   N AIN IIY F  + FR   L L++C ++  R   +N    T  A   NT
Sbjct:   48 LAISDLLLLIFFSPTF----IFKGAYTHPGGL---AGDVLCSLVTGES-------FAWMGGYASALFLVAIAIERFYAVTNPHSNL----VSITNSNLKILVVVCWLFAIAWNAIGFIVKRYNEQLGFCTMEWPADYSFKVYSALCF-------------------VVLGVIPICTMCVLYSRVIHQLWFRREVEQVNNQEADRQRRKKATKMVIVVSFIYALSWIPELSIFLIVAY-----APTSIRGDIA--YPASVAMVTFNSAINPIIYSFHNERFRRHLLNLLRCRVSGGRVAPNN---RTVGAGHNNT 314
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Nematostella
Match: EDO42096 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2E1])

HSP 1 Score: 47.3654 bits (111), Expect = 8.820e-6
Identity = 52/230 (22.61%), Postives = 101/230 (43.91%), Query Frame = 2 
Query:  527 GKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFP-MKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYLWINN------LIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCH 1195
            G  +   + F    + + SI T+V ++ ER   V    + R+Q   I    I+  +++VVS +I  P  + +    HP    ++ V N+  W ++       I + I+  IP + +V  +  I   L+           S  + +++ +T  L VV+ +F     P ++V  +     + G          + + ++ ++  IN A+N I+YCF    FR++   +VKC 
Sbjct:   98 GNPLCKLQGFLVETSYSASILTLVAISYERLRSVAAKGLARSQ--RIERRTIICKLIWVVSAIICAPLLYGYSAVQHPYTGKTLCV-NRVTWGDDGRQIYYAIHAVIIYCIPLVFMVWAHWKIFSFLKKHAHGK---SVSAVESKQRKVTQMLAVVTLIFVSCWTPFILVRALRYFFVYEG---------LEIWKLTQLIIIINSAVNPILYCFYSGQFRSSFKDMVKCR 312
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Medaka
Match: gpr142 (probable G-protein coupled receptor 142 [Source:NCBI gene;Acc:101163443])

HSP 1 Score: 77.7962 bits (190), Expect = 2.974e-15
Identity = 60/206 (29.13%), Postives = 103/206 (50.00%), Query Frame = 2 
Query:  563 FAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDI--ASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIH-GINEWTGD-KSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRT 1168
            FAA   SI++ V +TV+R++ +  P+   Q      A+ +++ +  ++L   +P+F+  D+   SHP      ++ +  +W +     TI+  +PC I  V NS II+TLR R R        +  ++    T  LL ++ +F +L  P   V+  H  ++    D + HL      AY +S +L  +N A+NF +YCF  K FR 
Sbjct:  113 FAANHASIWSTVPLTVDRYVALCHPLLHRQISYPARARRIIASVLALALASGVPFFWWSDMWRNSHP----PTALDSVLIWTH----VTIIYFLPCSIFFVLNSLIIHTLRVRKRRQPCQKGHRPAQRLGKTTAMLLAITSVFSVLWAPRTAVVIYHLYVSSVHSDWRVHL------AYDLSNMLAMLNTAVNFFLYCFVSKPFRN 304
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Medaka
Match: nmur3 (neuromedin-U receptor 2-like [Source:NCBI gene;Acc:101165474])

HSP 1 Score: 56.225 bits (134), Expect = 4.206e-8
Identity = 81/308 (26.30%), Postives = 130/308 (42.21%), Query Frame = 2 
Query:  374 SHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGV--RYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRN-------KYLWINNL---IESTILSLIPCLIIVVCNSCI-IYTLRGRLRLNLLVDTSKAKKQEKDITI----RLLVVSFMFFILTIPSLVVIGIH-------GINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDN 1225
            ++FYL  LAV D++ L+  +P              IY +   YP     F   G Y   F+ F        SI  +  ++VER+I V+ P+K     T   AK +++V++VVS++ +IP     + + H  F L   +         K LWI NL   I +     IP +II V    + I+  R R      +  S      +++T+    R  V+  +  ++ +  L     H        +++WT D  H        + +S ILF ++ A+N IIY      FR     LV  H+ D    RD+
Sbjct:  125 TNFYLVSLAVSDLLVLMFGMP------------LEIYDLWQNYP---FPFGEGGCY---FKTFLFETVCFASILNVTALSVERYIAVVHPLKTRYLSTNQHAKRVITVVWVVSMVCAIP-----NTSLHGIFYLPEKMEESAICTVLKPLWIYNLLMQITTACFYFIPMMIISVLYLVMGIHLGRERRHARRHLGKSCYSSSRRNLTVENGRRRQVIKMLSIVVAVFGLCWAPFHIERVLWSSVSQWT-DLMH--NVYQYVHILSGILFYLSSAVNPIIYSLLSTRFRECFRELVCSHVEDSSSVRDS 406
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Medaka
Match: f2r (coagulation factor II (thrombin) receptor [Source:ZFIN;Acc:ZDB-GENE-060526-30])

HSP 1 Score: 50.0618 bits (118), Expect = 3.389e-6
Identity = 58/281 (20.64%), Postives = 122/281 (43.42%), Query Frame = 2 
Query:  473 YHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAART-CSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFS------FDIASHPCFPLS--ISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFM----FFILTIPSLVVIGIHGIN--EWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTSANDGNTRN 1270
            YH +G      W+  S M + +T      +F     CS+  +  ++++RF+ V++PM   ++ +   A  + + M++VSL    P   S       D+    C  +     ++  YL+    + S +   +P +   VC + I+ TL            ++   + +    R +V++ M    F +   P+ +++ +H +     +GD S+       AY +S+ + +I+  ++ ++Y F     R   + L  C     R  + +L  ++T A DG+T +
Sbjct:  154 YHYHG----NNWIYGSFMCRLVTA-----SFHCNMYCSVLLVTCISIDRFLAVVYPMDSLKWRSPQTAAAVCAAMWLVSLGGVFPLLMSTQTVRLSDLGITTCHDVQGVEKLQGFYLYFFP-VYSAVFFFLPLIFTAVCYTRILQTL------------AEGSAENRSKRTRAMVMAGMVLLVFVVCFTPTNIILMVHYVQLAHSSGDGSY------QAYLLSVCMGSISCCLDPLLYYFGSSQCRKQVMTLFGCR----RPAQSSLEAQSTRA-DGSTNS 401
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Medaka
Match: cysltr1 (cysteinyl leukotriene receptor 1 [Source:NCBI gene;Acc:101162692])

HSP 1 Score: 49.2914 bits (116), Expect = 4.633e-6
Identity = 64/276 (23.19%), Postives = 123/276 (44.57%), Query Frame = 2 
Query:  377 HFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHP-----CF--PLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKD--ITIRLLVVSFMFFILTIPSLVV---IGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRT 1168
            H Y+  LA+ D++ +++ LP       LR  YY   G      W E    G ++     +F +    CSIY +  ++V RF+ +++P++  Q  T+  ++I+   +++   L    +  S     +      CF  P   S +   L + N I      L+P LII +C   I+ TL  R        T  A++Q+      IR++V+  + F+ +     +   + +H ++      S  + A   +  +++ L A N   + ++Y F+G+ FR+
Sbjct:   59 HVYMVNLALSDLLCVMT-LP-------LRVSYYARRG-----RWEE----GDFLCRISSYFLYVNLYCSIYFMTAMSVTRFLAIVYPVQNLQLVTVNKSRIVCVCIWIFCSLSMSSFLMSGQHVDNSTNIIKCFEPPGQDSKQLTKLLLLNYIGLVFGFLLPFLIIGICYVGIVRTLLSR--------TQTARRQQASGVRAIRMIVIVLLTFLFSFTPYHIQRTVHLHSLSRENSSCSE-QIAIQKSVVVTLCLAAANSCFDPLLYFFSGEGFRS 308
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Planmine SMEST
Match: SMESG000076050.1 (SMESG000076050.1)

HSP 1 Score: 721.079 bits (1860), Expect = 0.000e+0
Identity = 383/384 (99.74%), Postives = 383/384 (99.74%), Query Frame = 2 
Query:  185 MSTSLATINCLDPKQVFIEVFTPIPNYATTIFGVYFLPXXXXXXXXXXXXXXXXLRRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTSANDGNTRNLDHGDSVANRESFQQKRSLLNS 1336
            MSTSLATINCLDPKQVFIEVFTPIPNYATTIFGVYFLPIIILFGVIGNIISIIILRRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKI LSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTSANDGNTRNLDHGDSVANRESFQQKRSLLNS
Sbjct:    1 MSTSLATINCLDPKQVFIEVFTPIPNYATTIFGVYFLPIIILFGVIGNIISIIILRRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKISLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTSANDGNTRNLDHGDSVANRESFQQKRSLLNS 384
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Planmine SMEST
Match: SMESG000076048.1 (SMESG000076048.1)

HSP 1 Score: 209.534 bits (532), Expect = 1.742e-65
Identity = 102/153 (66.67%), Postives = 126/153 (82.35%), Query Frame = 2 
Query:  809 LIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTSANDGNTR 1267
            ++E TIL L PCLIIV+CN CII+TLRGRL+L++L++ +  KKQE+DITIRLL +SF FF+LTIPSLVV+ IH + +   + S+LRG +ADA+A+SIILFA+NLAINFIIYC TGK FRTAALALVKC+  DM KYR NLVTETT+  D N R
Sbjct:    1 MVEFTILCLFPCLIIVICNGCIIFTLRGRLKLSILINNNDHKKQERDITIRLLAISFAFFVLTIPSLVVVSIHTVQQARKNPSYLRGPEADAFALSIILFAVNLAINFIIYCLTGKNFRTAALALVKCNWKDMCKYRANLVTETTAV-DNNDR 152
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Planmine SMEST
Match: SMESG000045308.1 (SMESG000045308.1)

HSP 1 Score: 189.504 bits (480), Expect = 3.394e-55
Identity = 127/352 (36.08%), Postives = 195/352 (55.40%), Query Frame = 2 
Query:  200 ATINCLDPKQVFIEVFTPIPNYATTIFGVYFLPXXXXXXXXXXXXXXXXLRRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTSAND 1255
             T NC  P +   ++F P+       F +  +P+I +FG++GN+ S IIL+  A+K  SH YL  L+V D +++L+F  +F+  ++L+P    +        ++E  L      PFR F +F+ R  S + IVI T++RF++V FP    +  TI    + L    + S LI+IPW   +D A  PC   ++   N  L+    +E  ++SL+P LII +CN  I+  LR R + + L    +A +QEK ITIRLL+VS  F  L  PS VVI I  + +      +  G  ADA+ I   L+ +NL+INFI+YC TG TFR AA  L++C++N M+ YR  ++   TS  +
Sbjct:    8 TTPNCSLPVKAS-KLFIPVGQDGVMWFQLIAIPLISIFGIVGNVFSFIILKSGASKTVSHLYLVCLSVTDSVTILTFQYSFYTNLVLQPI---LLKFDDKVTFIEEYLTNYRTCPFRTFTSFSMRLLSTWVIVIFTIDRFVVVAFPFHSRKISTIRNTILALVAALITSFLINIPWLVGYDKAPVPCTNRALCKGNDILFYMVFVEIILMSLVPSLIISICNVSIVLILRKRQKHSTLYSKKEALQQEKRITIRLLLVSTAFVTLNFPSFVVIIIKTVGKIKYKNLYNSGPMADAFHIGTFLYLLNLSINFILYCLTGSTFRKAAWNLLQCNINKMKHYRKVILLSNTSETN 355
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Planmine SMEST
Match: SMESG000045308.1 (SMESG000045308.1)

HSP 1 Score: 175.252 bits (443), Expect = 4.959e-50
Identity = 125/352 (35.51%), Postives = 183/352 (51.99%), Query Frame = 2 
Query:  200 ATINCLDPKQVFIEVFTPIPNYATTIFGVYFLPXXXXXXXXXXXXXXXXLRRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTSAND 1255
             T NC  P +   ++F P+       F +  +P+I +FG++GN+ S IIL+  A+K  SH YL  L+V D   LL F                         ++E  L      PFR F +F+ R  S + IVI T++RF++V FP    +  TI    + L    + S LI+IPW   +D A  PC   ++   N  L+    +E  ++SL+P LII +CN  I+  LR R + + L    +A +QEK ITIRLL+VS  F  L  PS VVI I  + +      +  G  ADA+ I   L+ +NL+INFI+YC TG TFR AA  L++C++N M+ YR  ++   TS  +
Sbjct:    8 TTPNCSLPVKAS-KLFIPVGQDGVMWFQLIAIPLISIFGIVGNVFSFIILKSGASKTVSHLYLVCLSVTDSPILLKF--------------------DDKVTFIEEYLTNYRTCPFRTFTSFSMRLLSTWVIVIFTIDRFVVVAFPFHSRKISTIRNTILALVAALITSFLINIPWLVGYDKAPVPCTNRALCKGNDILFYMVFVEIILMSLVPSLIISICNVSIVLILRKRQKHSTLYSKKEALQQEKRITIRLLLVSTAFVTLNFPSFVVIIIKTVGKIKYKNLYNSGPMADAFHIGTFLYLLNLSINFILYCLTGSTFRKAAWNLLQCNINKMKHYRKVILLSNTSETN 338
[Close]
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Planmine SMEST
Match: SMESG000018211.1 (SMESG000018211.1)

HSP 1 Score: 157.918 bits (398), Expect = 1.199e-43
Identity = 110/307 (35.83%), Postives = 175/307 (57.00%), Query Frame = 2 
Query:  347 LRRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIYGVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLFPMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVRNKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLV-DTSKAKKQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADAYAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVTETTSANDGNT 1264
            L+ ++ K+SS FY+  L +FD +SL+  +  F+  +++ P    I   RY       +  G   T  + +  F+ RT SI+TIV+ T+ER + V FP+   + CTI  AKI + ++ +VSLL SI W FSF+      + L +    + +    ++E  +LS++P LII+V N  I+ TLR R RL+L+  +  K KK++  ITI+LL VS  F +LTIP  + + I+  +E      + +G  A+ Y ++ +LF +N AINF++YCF G  FR AAL ++ C    MR+ R   + ET S +  +T
Sbjct:   19 LKDSSRKVSSFFYIRCLTIFDSLSLILTMLGFYMTLVIHPML--ISNERYRNISYIINQWGTCQT--KTYLAFSCRTMSIWTIVVFTLERLVCVKFPIISMKVCTIRNAKITVVILVIVSLLSSIDWIFSFEKVLCKKYNLYVCKPKQNMLKFRILEMLMLSVVPALIIIVSNIIIVLTLRQRRRLSLVAYEEPKNKKRDNKITIQLLAVSTTFTLLTIPQCISVIINTRHEQLKLTDNRQGHLANFYHLTFLLFTLNFAINFVLYCFIGHNFRNAALNIILCRFRQMRQLR-RAIFETVSNDTRHT 320
The following BLAST results are available for this feature:
BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
GPR1392.637e-1027.66G protein-coupled receptor 139 [Source:HGNC Symbol... [more]
GHSR4.716e-724.46growth hormone secretagogue receptor [Source:HGNC ... [more]
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
frpr-101.925e-1228.83FMRFamide Peptide Receptor family [Source:UniProt... [more]
frpr-61.455e-925.71FMRFamide Peptide Receptor family [Source:UniProt... [more]
frpr-82.237e-823.78FMRFamide Peptide Receptor family [Source:UniProt... [more]
frpr-117.043e-724.21FMRFamide Peptide Receptor family [Source:UniProt... [more]
frpr-49.718e-726.61FMRFamide Peptide Receptor family [Source:UniProt... [more]
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4
Match NameE-valueIdentityDescription
FMRFaR3.058e-1127.41gene:FBgn0035385 transcript:FBtr0340706[more]
FMRFaR3.058e-1127.41gene:FBgn0035385 transcript:FBtr0332085[more]
FMRFaR3.058e-1127.41gene:FBgn0035385 transcript:FBtr0072980[more]
CNMaR7.804e-928.57gene:FBgn0053696 transcript:FBtr0091684[more]
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
gpr1428.226e-1529.63G protein-coupled receptor 142 [Source:ZFIN;Acc:ZD... [more]
trhr22.263e-726.32thyrotropin releasing hormone receptor 2 [Source:Z... [more]
trhr22.510e-726.32thyrotropin releasing hormone receptor 2 [Source:Z... [more]
trhr22.812e-725.39thyrotropin releasing hormone receptor 2 [Source:Z... [more]
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3
Match NameE-valueIdentityDescription
GPR1421.489e-1326.91G protein-coupled receptor 142 [Source:HGNC Symbol... [more]
gpr1391.333e-728.15G protein-coupled receptor 139 [Source:NCBI gene;A... [more]
epx3.011e-623.21eosinophil peroxidase [Source:Xenbase;Acc:XB-GENE-... [more]
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Gpr1392.462e-1028.99G protein-coupled receptor 139 [Source:MGI Symbol;... [more]
Gpr1421.988e-929.05G protein-coupled receptor 142 [Source:MGI Symbol;... [more]
Gpr1422.093e-929.05G protein-coupled receptor 142 [Source:MGI Symbol;... [more]
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9VZW5|FMAR_DROME3.066e-1027.41FMRFamide receptor OS=Drosophila melanogaster OX=7... [more]
sp|Q6DWJ6|GP139_HUMAN1.266e-927.66Probable G-protein coupled receptor 139 OS=Homo sa... [more]
sp|P0C0W8|GP139_RAT1.588e-928.75Probable G-protein coupled receptor 139 OS=Rattus ... [more]
sp|Q80UC8|GP139_MOUSE1.722e-928.99Probable G-protein coupled receptor 139 OS=Mus mus... [more]
sp|Q7TQN9|GP142_MOUSE1.390e-829.05Probable G-protein coupled receptor 142 OS=Mus mus... [more]
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5J4NPF49.179e-5031.23G_PROTEIN_RECEP_F1_2 domain-containing protein OS=... [more]
A0A267EIX81.200e-4432.73G_PROTEIN_RECEP_F1_2 domain-containing protein (Fr... [more]
A0A1I8I6Q03.496e-4432.92G_PROTEIN_RECEP_F1_2 domain-containing protein OS=... [more]
A0A267DP979.342e-4232.13G_PROTEIN_RECEP_F1_2 domain-containing protein (Fr... [more]
A0A267FGB42.361e-4132.05G_PROTEIN_RECEP_F1_2 domain-containing protein (Fr... [more]
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
gpr1421.245e-1026.34probable G-protein coupled receptor 142 [Source:NC... [more]
agtr1b3.593e-825.27type-1 angiotensin II receptor A-like [Source:NCBI... [more]
ENSAMXT00000045631.12.097e-725.40pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
ENSAMXT00000048391.15.074e-726.96pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
agtr25.950e-724.76type-2 angiotensin II receptor-like [Source:NCBI g... [more]
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO482615.207e-824.84Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO420968.820e-622.61Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
gpr1422.974e-1529.13probable G-protein coupled receptor 142 [Source:NC... [more]
nmur34.206e-826.30neuromedin-U receptor 2-like [Source:NCBI gene;Acc... [more]
f2r3.389e-620.64coagulation factor II (thrombin) receptor [Source:... [more]
cysltr14.633e-623.19cysteinyl leukotriene receptor 1 [Source:NCBI gene... [more]
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BLAST of G_PROTEIN_RECEP_F1_2 domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000076050.10.000e+099.74SMESG000076050.1[more]
SMESG000076048.11.742e-6566.67SMESG000076048.1[more]
SMESG000045308.13.394e-5536.08SMESG000045308.1[more]
SMESG000045308.14.959e-5035.51SMESG000045308.1[more]
SMESG000018211.11.199e-4335.83SMESG000018211.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30024636 ID=SMED30024636|Name=G_PROTEIN_RECEP_F1_2 domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1440bp
TGATAGTTAAATATGGTCAAATTTGTGAAATATATTTATATTTTGACAAA
TTTGAATTTAAAATTAAATTATTGTAGAGCAATTTAAAATTAGATTTTTT
CTTGAAGAAATAATTTTTAGTAATTTTCACATTTTTATTTTTAGTCTATT
TCAATTATTTTTAAAAAAAAGATCAAAAATAACAATGTCAACATCTCTTG
CAACAATTAATTGCTTAGATCCTAAACAAGTCTTTATCGAAGTTTTTACA
CCGATTCCTAATTATGCTACTACGATTTTCGGTGTTTATTTTTTACCGAT
TATCATTTTATTTGGAGTTATTGGTAATATTATTTCTATAATTATTTTGC
GTCGAGCTGCCACTAAAATGTCATCTCATTTCTATCTCTGGTGGTTAGCG
GTTTTTGATATAATTTCATTGTTGAGTTTCCTCCCAACATTTTGGGCTGT
GATGCTTTTGCGGCCTTATTATTACCATATTTACGGGGTCCGGTATCCAG
CTGGCTGGGTAGAGTTTTCTCTAATGGGTAAATATATCACTCCATTTCGA
ATGTTTTTCACATTTGCCGCCAGAACCTGTTCAATCTATACAATTGTCAT
TGTCACTGTCGAACGGTTCATTATGGTTTTGTTTCCGATGAAACGGACTC
AATTCTGCACGATTTATGTAGCGAAAATTTTATTATCTGTCATGTTCGTT
GTGTCATTATTGATAAGTATTCCGTGGTTTTTCAGTTTTGATATCGCTTC
CCATCCCTGTTTTCCATTGAGTATTTCCGTTCGCAATAAATATCTGTGGA
TAAATAATTTGATTGAATCTACCATTCTCTCCTTGATCCCGTGCTTAATT
ATTGTCGTATGCAATTCCTGCATAATCTACACTCTTCGTGGCCGGCTGCG
TCTCAATCTGCTAGTTGACACGTCCAAGGCGAAAAAACAAGAAAAAGATA
TCACAATTCGTTTGCTGGTCGTTTCGTTCATGTTTTTCATTCTCACAATT
CCCTCGTTAGTAGTTATTGGCATTCATGGAATTAACGAATGGACAGGGGA
TAAGTCTCACTTGCGTGGGGCCAAAGCCGACGCCTATGCCATTTCGATAA
TTCTTTTTGCAATTAATCTCGCTATCAACTTTATCATTTATTGCTTTACT
GGGAAAACTTTTCGAACTGCTGCGTTGGCTTTGGTGAAGTGCCATTTGAA
TGACATGAGAAAATACCGTGACAATCTCGTTACGGAAACGACTTCGGCCA
ATGATGGCAATACTCGAAATCTTGATCATGGAGACAGTGTTGCAAACAGA
GAAAGCTTTCAACAGAAAAGATCTTTGCTCAACTCGAAAGTTTAAATCGT
TTTTTTCTTAAAATTAAAGTGATTGGTTAAATAAAACATTATTTCAAATT
TTGCTTTCATTTCATATCTGACCACTTTGTAAGATGTTTG
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protein sequence of SMED30024636-orf-1

>SMED30024636-orf-1 ID=SMED30024636-orf-1|Name=SMED30024636-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=387bp
MSTSLATINCLDPKQVFIEVFTPIPNYATTIFGVYFLPIIILFGVIGNII
SIIILRRAATKMSSHFYLWWLAVFDIISLLSFLPTFWAVMLLRPYYYHIY
GVRYPAGWVEFSLMGKYITPFRMFFTFAARTCSIYTIVIVTVERFIMVLF
PMKRTQFCTIYVAKILLSVMFVVSLLISIPWFFSFDIASHPCFPLSISVR
NKYLWINNLIESTILSLIPCLIIVVCNSCIIYTLRGRLRLNLLVDTSKAK
KQEKDITIRLLVVSFMFFILTIPSLVVIGIHGINEWTGDKSHLRGAKADA
YAISIILFAINLAINFIIYCFTGKTFRTAALALVKCHLNDMRKYRDNLVT
ETTSANDGNTRNLDHGDSVANRESFQQKRSLLNSKV*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0007165signal transduction
GO:0007186G-protein coupled receptor signaling pathway
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000018Category 4 cell
PLANA:0000034epidermis
Vocabulary: INTERPRO
TermDefinition
IPR000276GPCR_Rhodpsn
IPR017452GPCR_Rhodpsn_7TM
Vocabulary: molecular function
TermDefinition
GO:0004930G-protein coupled receptor activity
Vocabulary: cellular component
TermDefinition
GO:0016021integral component of membrane
GO:0016020membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000276G protein-coupled receptor, rhodopsin-likePRINTSPR00237GPCRRHODOPSNcoord: 126..148
score: 20.0
coord: 32..56
score: 20.32
coord: 64..85
score: 23.99
coord: 208..231
score: 20.54
coord: 162..183
score: 21.86
coord: 301..327
score: 28.47
IPR000276G protein-coupled receptor, rhodopsin-likePFAMPF000017tm_1coord: 49..319
e-value: 1.9E-9
score: 37.2
IPR000276G protein-coupled receptor, rhodopsin-likePROSITEPS00237G_PROTEIN_RECEP_F1_1coord: 132..148
NoneNo IPR availableGENE3DG3DSA:1.20.1070.10coord: 24..347
e-value: 2.0E-46
score: 160.4
NoneNo IPR availablePANTHERPTHR46641FAMILY NOT NAMEDcoord: 26..363
NoneNo IPR availableCDDcd149787tmA_FMRFamide_R-likecoord: 34..330
e-value: 7.83625E-37
score: 133.527
NoneNo IPR availableSUPERFAMILYSSF81321Family A G protein-coupled receptor-likecoord: 21..352
NoneNo IPR availableTMHMMTMhelixcoord: 258..280
NoneNo IPR availableTMHMMTMhelixcoord: 126..148
NoneNo IPR availableTMHMMTMhelixcoord: 31..53
NoneNo IPR availableTMHMMTMhelixcoord: 66..88
NoneNo IPR availableTMHMMTMhelixcoord: 209..231
NoneNo IPR availableTMHMMTMhelixcoord: 161..183
NoneNo IPR availableTMHMMTMhelixcoord: 300..322
IPR017452GPCR, rhodopsin-like, 7TMPROSITEPS50262G_PROTEIN_RECEP_F1_2coord: 47..319
score: 26.691