Degenerin unc-8

Overview
NameDegenerin unc-8
Smed IDSMED30024562
Length (bp)1746
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Degenerin unc-8 (SMED30024562) t-SNE clustered cells

Violin plots show distribution of expression levels for Degenerin unc-8 (SMED30024562) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Degenerin unc-8 (SMED30024562) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Degenerin unc-8 (SMED30024562) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30024562

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30024562h1SMcG0013455 dd_Smed_v4_14159_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30024562h1SMcG0013455 dd_Smed_v4_14159_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30024562h1SMcG0013455 dd_Smed_v4_14159_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30024562h1SMcG0013455 dd_Smed_v6_14159_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Degenerin unc-8 vs. TrEMBL
Match: S5W2R2 (Asic OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 439.499 bits (1129), Expect = 1.047e-145
Identity = 221/496 (44.56%), Postives = 338/496 (68.15%), Query Frame = 3
Query:   99 MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHMNLDVFFTTRIMQIRNNIPCHTFGINHLESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEMFTKQCKQYKAIKCEELYYKIDKQTDMFVEMWSKSENDRRSSFNKVRVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFY 1586
            MIDLIQ+STIHG+ HI+SA +K  K+ WC LF +G+ AII+NI+FI +K+ S P  ++Y+ ++EPFIWPDIT CNP  PY    +S+P+ +W    +++K V   +   +   ++IH  + ND+ELEE T+ M+SAD  KL+A  +++    + +   H G+YF  +++ ++ +  + +    FT++I+Q+RNNIPCHTF ++    +  K IKSL+F ++ N +SYK+FNSSY  +S+ +Y+SNK ++  +  I+L PG++N+V LTQ+R+ Y+GL R CRNE F+ +LYDSLL    ++ G+Y+ CK+I SQ  +VK CNCY+ FLPI++N +GFPRLCLNA++F++AE+L+NA+C+   + ++   +  +  F  +CK Y+ I C ++ YKID + ++ V++WSKS NDRR    K    K F       D+   ++D+ ++  I R    GDLY EE  Y FS+LLSD+GGLMGLWLGLS++G FEI+EF Y
Sbjct:    1 MIDLIQSSTIHGIGHIFSATNKIFKVLWCILFLVGVIAIIVNIVFISMKFLSNPVIISYTFEHEPFIWPDITFCNPTDPYAFTINSQPYLHWIETLNKTKRVAGKVARQTSMSQLIHSRRENDYELEERTIAMSSADPAKLQATAFQNYLYRIGYIKAHKGLYFSKEFQSSS-TKLNEDWKSLFTSQIVQMRNNIPCHTFHLDKSRIVKQKFIKSLLFRFKLNEESYKIFNSSYTFQSMFLYISNKDEIPQSNEIILTPGYNNVVQLTQNRHSYTGLRRTCRNEKFEAELYDSLLQSTEKYSGSYDDCKKIVSQQKYVKYCNCYNSFLPIFKNSSGFPRLCLNASIFSEAEVLKNAKCMINTFRKYAESDKARRRFYNRCKMYRPIPCNKVLYKIDHRKEILVDLWSKSTNDRRREIIKTLYLKTFQTNETSLDFVEKVKDNIMQLIINRDNESGDLYKEEREYPFSELLSDVGGLMGLWLGLSVIGLFEIVEFVY 495          
BLAST of Degenerin unc-8 vs. TrEMBL
Match: A0A5J4NUF1 (Uncharacterized protein OS=Paragonimus westermani OX=34504 GN=DEA37_0013022 PE=3 SV=1)

HSP 1 Score: 255.373 bits (651), Expect = 2.117e-72
Identity = 159/531 (29.94%), Postives = 277/531 (52.17%), Query Frame = 3
Query:   87 FHLEMIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFI-YVHHTIPHPGIYFVNDYKDNNPSDFHMN--LDVFFTTRIMQIRNNIPCHTFGINH-LESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLP---IYEN--VTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEM-FTKQCKQYKAIKCEELYYKI-DKQTDMFVEMWSKSENDRRSSFNKVRVEKIFG----------------KGNKHKDYHTA------LRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEF 1580
            FH+ +  L+++ST+HG++H+ +A +K  ++ W  L   GI     N+ FI+ +Y + P   +Y  +YE FIWPDIT+CN  APY L       K W+ + +Q+    + L +S   F  I     N+  ++ +  +  S  +  +        FI +V   + + GI    +   N     H+N  L  +F T+++Q R N+PC+T  + H L ++    + S+    +FN +SY++ NSSY +  I +++S+ G    + PI +LPG+   + L  SR R       CR + +  +++D  L       G+   C  I SQ L++ +C+CYSPFLP   +Y +   +    LC N + F+ A+I +NA+C+ ++Y R++  ++   +   + C+Q++   C+++ YK+ D +    VE+WS S N+ R +F     + +F                 K +  KD  +       +RD+F   ++ R+   G+L  EE  Y  S+L+SD+GGLMGLW+G+S++G FEI+E 
Sbjct:   23 FHVGVERLLEHSTVHGLSHVSTAATKLGRITWFCLLLAGIAGFFTNLSFIIDRYLTRPVLTSYISEYEGFIWPDITLCNAMAPYSLHLHGRIPK-WQALRNQASAFAQKLNSS--LFASIDSQDQNEIAIQALMYSTLSPPEYGVGE---PEEFIQFVATDVGYQGIILTVEISGNMT---HLNPPLKKYFHTQVLQKRYNVPCYTLQLRHSLTAVQSNQVNSIGLGVKFNVESYRIINSSYASPYIDLFISHPGHAPHDDPIEMLPGYTLSLSLRMSRLRREPARLSCRTDFYTTEVFDPDLVTKRRVNGSATFCHRIVSQHLYLNSCHCYSPFLPYPVVYNHKLFSKMAILCFNMSRFSVAQINRNADCMLRIYERYQLSSVYNSVPEARACEQFRKPLCDDVEYKLSDIRRTAMVELWSNSYNEARIAFLTSSFQNLFSSDIPPEQLVSWLDSDTKDDNTKDNDSMPKILKYMRDNFGLLSVNRKSELGELVREELEYPLSELMSDVGGLMGLWIGISVIGLFEIVEL 544          
BLAST of Degenerin unc-8 vs. TrEMBL
Match: A0A4S2L913 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_009406 PE=3 SV=1)

HSP 1 Score: 250.366 bits (638), Expect = 9.882e-71
Identity = 166/529 (31.38%), Postives = 278/529 (52.55%), Query Frame = 3
Query:   87 FHLEMIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEIT-VTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHMNLDVFFTTRIMQIRNNIPCHTFGINH-LESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPI-----YENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNP----NITKEMFTKQCKQYKAI-KCEELYYKI--DKQTDMFVEMWSKSENDRRSSFNKV-------------RVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLF 1592
            FH+    L+++ST+HG++H+ SA S   ++ W  LF  GI    IN+  IV +Y S P   +   D++ F+WPDITICNP+APY +       K W  +   +K+V + +   SE F  I      + + + +   TM+ +D       +      +V     H GI    +  D N +     ++ +F T I+Q R NIPC+T  I   +     K ++ +    +FN +S+ + N+SY++ ++   +S  G +  ++PI LLPG+ + +GL   R++     RPCRN VF ++++D+ L       G+   C  I SQ L++K C CYSPFLP      + +    P LC N + F   ++ QNA+C+  +  ++++P    NI +    ++C+   ++  CE++ +++   ++T ++ E+WS+  ND R SF K              R+ K F   N  +     LR++F   TI+R+   G+L  E+  Y  ++LLSDIGGLMGLW+G+S++G FE+LE   L 
Sbjct:   65 FHVNARRLLEHSTVHGLSHVSSASSHVGRITWFVLFVAGITGFCINLSLIVSRYVSRPVLTSIFNDHDDFVWPDITICNPSAPYVVHLYDRHEK-WLRLRDWAKNVAQYI--PSELFAAIDEADKVEIKTQALMHSTMSPSD---FGVGIPNETVNFVAADTGHYGIVLTVEL-DGNLTYLSAPMEQYFRTHILQKRYNIPCYTLQIEQGMPEDERKRVRKVALGLKFNIESHMIINTSYVSPTLDFIISRPGHMPHDEPIELLPGYMHYIGLNFQRFKREPSKRPCRNNVFDVEVFDANLATKYPVHGSATLCHRILSQNLYIKYCGCYSPFLPYPVIPSHPDFDDSPVLCFNMSRFKIEQLNQNAKCMFNLLEKYRDPVTYMNIPE---ARECEYLGSVPPCEDIEHQLIQTRRTPLW-ELWSEKYNDARLSFLKAAFQLVFEVDIVQNRLGKSFHINNDSEPALRYLRENFALITIERKVEKGELIREDLEYPLAELLSDIGGLMGLWIGISVIGLFEVLELLGLM 582          
BLAST of Degenerin unc-8 vs. TrEMBL
Match: A0A504YRR8 (Degenerin unc-8 OS=Fasciola gigantica OX=46835 GN=FGIG_05554 PE=3 SV=1)

HSP 1 Score: 248.825 bits (634), Expect = 1.342e-69
Identity = 169/543 (31.12%), Postives = 279/543 (51.38%), Query Frame = 3
Query:   87 FHLEMIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPY--YLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHM---------NLDV----FFTTRIMQIRNNIPCHTFGINH-LESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFL---------PIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNP----NITKEMFTKQCKQYKAI-KCEELYYKIDK-QTDMFVEMWSKSENDRRSSFNKVRVEKIFGKG----------NKHKDYHTAL---RDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFF 1583
            F+L +  L+++ST+HG++H+ +A ++  +  W  L+  G+     N+ FIV +Y + P   +Y  D+E FIWPDIT+CNP APY  +L N SE +    N+ HQ    V    + + F  I      ++ E EE+TV      Q  + + V    F       PH  ++FV    D   +  H+         NLD+    +F  +++Q R NIPC+T  ++  L      + K +    +FN+DS  + NSSY   +I +++S  G +  ++P+ +L G+ + V +T  R+       PCR E F  +++D+ L    E  G+ + C ++ SQ L++ +C CYSPFL         P+Y++    P LC N + F  + I +NA C+ +VY +FK      N+ +  F   C+ ++A   CE + Y ++  +    +E W+ + N+ RS+F     E +FG+           N   +  + L   R++F    I R+   G L  EE  Y  S+LLSD+GGLMGLW+G+S++G FE++E F
Sbjct:   27 FYLGVRRLLEHSTVHGLSHVSTASTRIGRSVWLILWMAGVAGFFTNLSFIVSRYMTRPVLTSYKHDHELFIWPDITLCNPMAPYPVHLNNRSEKW----NLLHQLATAVSRNISGNLFATI------DEAEQEEVTV------QALIHSTVSPMEF---GANDPHELVHFV--AVDKGQTGIHLTIEMDATFTNLDIPKHRYFHVQVLQKRYNIPCYTLRLDQVLNEEECASTKQVSLGLKFNHDSNLIINSSYAPFNIDLFISLPGHMPEDEPMEILSGYSHKVTVTMGRFTRERTRLPCRTEQFVTQVFDADLKTQREVVGSADFCLKLLSQRLYIDHCGCYSPFLPYPVMGQDHPLYQH----PVLCFNMSHFNASGIDRNARCMYEVYTQFKEDFIYMNLPEAGF---CETFRATPPCESINYVLESPRRTPIIEFWADTVNEARSAFVTSTFESVFGQDLPEERLKQMVNNSGNTSSLLFYMRNNFGLVKITRKLPRGTLTHEELEYPLSELLSDVGGLMGLWVGISVIGLFEVVELF 541          
BLAST of Degenerin unc-8 vs. TrEMBL
Match: A0A4E0RSD9 (Degenerin unc-8 OS=Fasciola hepatica OX=6192 GN=D915_000009 PE=3 SV=1)

HSP 1 Score: 246.514 bits (628), Expect = 8.751e-69
Identity = 168/543 (30.94%), Postives = 277/543 (51.01%), Query Frame = 3
Query:   87 FHLEMIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPY--YLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHM---------NLDV----FFTTRIMQIRNNIPCHTFGINH-LESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFL---------PIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNP----NITKEMFTKQCKQYKAI-KCEELYYKIDK-QTDMFVEMWSKSENDRRSSFNKVRVEKIFGKG----------NKHKDYHTAL---RDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFF 1583
            F+L +  L+++ST+HG++H+ +A ++  +  W  L+  G+     N+ FIV +Y + P   +Y  D+E FIWPDIT+CNP APY  +L N SE +    N+ HQ    V    + + F  I      ++ E EE+TV      Q  + + V    F       PH  ++FV    D   +  H+         NLD+    +F  +++Q R NIPC+T  ++  L      + K +    +FN+DS  + NSSY   +I +++S  G +  ++P+ +L G+ + V +T  R+       PCR E F  +++D+ L    E  G+ + C ++ SQ L++ +C CYSPFL         P+Y+     P LC N + F  + I +NA C+  VY +FK      N+ +  +   C+ ++A   CE + Y ++  +    +E W+ + N+ RS+F     E +FG+           N   +  + L   R++F    I R+   G L  EE  Y  S+LLSD+GGLMGLW+G+S++G FE++E F
Sbjct:   27 FYLGVRRLLEHSTVHGLSHVSTAGTRIGRSVWLILWMAGVAGFFTNLSFIVSRYMTRPVLTSYKHDHELFIWPDITLCNPMAPYPVHLNNRSEKW----NLLHQLATAVSRNISGNLFATI------DEAEQEEVTV------QALIHSTVSPMEF---GANDPHELVHFV--AVDKGQTGIHLTIEMDATFTNLDIPKHRYFHVQVLQKRYNIPCYTLRLDQVLNEEECASTKQVSLGLKFNHDSNLIINSSYAPFNIDLFISLPGHMPEDEPMEILSGYSHKVTVTMGRFTRERTRLPCRTEQFVTQVFDADLKTQREVVGSADFCLKLLSQRLYIDHCGCYSPFLPYPVMGQDHPLYQQ----PVLCFNMSHFNASGIDRNARCMYDVYTQFKEDFVYMNLPEAGY---CETFRATPPCESINYVLESPRRTPIIEFWADTVNEARSAFVTSTFESVFGQDLPEERLKQMVNNSGNTSSLLFYMRNNFGLVKITRKLPRGTLTHEELEYPLSELLSDVGGLMGLWVGISVIGLFEVVELF 541          
BLAST of Degenerin unc-8 vs. Ensembl Nematostella
Match: EDO42137 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2F2])

HSP 1 Score: 50.0618 bits (118), Expect = 2.177e-6
Identity = 21/44 (47.73%), Postives = 31/44 (70.45%), Query Frame = 3
Query: 1467 LYVEES-AYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLFF 1595
            L V+E+ AY+F  LLSDIGG MG+W+G+S + C E++E   +  
Sbjct:  446 LLVQETLAYTFMSLLSDIGGQMGMWIGISALTCAELIELVCVIL 489          
BLAST of Degenerin unc-8 vs. Ensembl Nematostella
Match: EDO31696 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX71])

HSP 1 Score: 49.2914 bits (116), Expect = 3.216e-6
Identity = 27/67 (40.30%), Postives = 42/67 (62.69%), Query Frame = 3
Query: 1413 LRDDFVEFTIKRQETFGDLYVEES-AYSFSQLLSDIGGLMGLWLGLSIVGCFEILEF-FYLFFKASC 1607
             RD+++E  I  +E   + ++EES AY     LSDIGG +GLW+G+S++   E++E    +FFK  C
Sbjct:  335 FRDNYLEVNIFFKEL--NYFIEESVAYELVNFLSDIGGQLGLWVGVSVMTGAEVVELALLIFFKVFC 399          
BLAST of Degenerin unc-8 vs. Planmine SMEST
Match: SMESG000011525.1 (SMESG000011525.1)

HSP 1 Score: 1070.07 bits (2766), Expect = 0.000e+0
Identity = 527/527 (100.00%), Postives = 527/527 (100.00%), Query Frame = 3
Query:   99 MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHMNLDVFFTTRIMQIRNNIPCHTFGINHLESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEMFTKQCKQYKAIKCEELYYKIDKQTDMFVEMWSKSENDRRSSFNKVRVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLFFKASCNNNPGTKDAIPNTTNEEFNALKIV 1679
            MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGIFAIIINIIFIVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHMNLDVFFTTRIMQIRNNIPCHTFGINHLESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEMFTKQCKQYKAIKCEELYYKIDKQTDMFVEMWSKSENDRRSSFNKVRVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLFFKASCNNNPGTKDAIPNTTNEEFNALKIV
Sbjct:    1 MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGIFAIIINIIFIVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHMNLDVFFTTRIMQIRNNIPCHTFGINHLESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEMFTKQCKQYKAIKCEELYYKIDKQTDMFVEMWSKSENDRRSSFNKVRVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLFFKASCNNNPGTKDAIPNTTNEEFNALKIV 527          
BLAST of Degenerin unc-8 vs. Planmine SMEST
Match: SMESG000069054.1 (SMESG000069054.1)

HSP 1 Score: 523.857 bits (1348), Expect = 0.000e+0
Identity = 254/505 (50.30%), Postives = 358/505 (70.89%), Query Frame = 3
Query:   99 MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHMNLDVFFTTRIMQIRNNIPCHTFGINHLESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEMFTKQCKQYKAIKCEELYYKIDKQTDMFVEMWSKSENDRRSSFNKVRVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLFFKASCNN 1613
            MI+L+++STIHG+NHIYSA  K +K  WC LF  GI  II+NI F+ ++YFSYP  ++Y+ ++EPF+WPDIT CNP AP+YL   S+ +KYW  I +QS+DVV+ L   ++ F+II   K  D ELEE T+ MAS++  KL A +++++  +V +T PH GIYF  D ++NNP  F  +L   F+T+I+QI+NNIPCHTF ++    ++P +++SL+F  RFNYDSY++FNSSY  RSI +Y+SN+ ++  ++ I L PGF+NI+ L+Q+R+ Y+GL R CR++ FK ++YD+L   V  FEG+YE CK+I SQ LFV  C CYSPFLPI++N TGFPRLCLNAT F+K ++L+NA+C+  VY  FK     ++ +  QC  +K  KC+ L Y++D + DM VE+WSK  N +R +  K      FGK    KD++  +RD+ V+  I+R+  + DL+ EE  Y FS+LLSDIGGLMGLWLG+S+VG FEILEFFYLF   +C N
Sbjct:    1 MIELVKSSTIHGINHIYSANGKLAKFLWCVLFIFGIIGIIVNICFVSIRYFSYPVLISYTFEHEPFVWPDITFCNPTAPFYLDRKSKAYKYWMQINNQSRDVVKMLVKETKLFQIIRESKETDFELEERTIAMASSNPVKLGADLFENHVKFVGYTRPHSGIYFNKDIQNNNPKTFPGDLKPLFSTQIVQIQNNIPCHTFHMHKSNILNPNSVQSLVFGLRFNYDSYEIFNSSYTTRSIFLYISNRDEIQQDQNIFLSPGFNNILSLSQNRHHYNGLRRKCRHKTFKFEVYDALFQNVKTFEGSYEDCKQIVSQRLFVDKCKCYSPFLPIFKNQTGFPRLCLNATFFSKTKLLENAKCMVNVYENFKKSGNFRKHYNNQCLIFKLHKCDLLSYQMDLRKDMLVELWSKVYNGKRLNSIKFMHSYYFGKNESKKDFNEVMRDNIVDLIIERKFEYSDLFKEEREYPFSELLSDIGGLMGLWLGMSVVGLFEILEFFYLFSINACLN 505          
BLAST of Degenerin unc-8 vs. Planmine SMEST
Match: SMESG000017678.1 (SMESG000017678.1)

HSP 1 Score: 479.174 bits (1232), Expect = 1.991e-164
Identity = 233/503 (46.32%), Postives = 345/503 (68.59%), Query Frame = 3
Query:   99 MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHMNLDVFFTTRIMQIRNNIPCHTFGINHLESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEMFTKQCKQYKAIKCEELYYKIDKQTDMFVEMWSKSENDRRSSFNKVRVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLFFKASC 1607
            MI+++Q+STIHGV+HI+ AKS+ +K+ W FLF  GI  I +NI+F+++KYFS P  +++ +D+EPFIWPD+T C P APYY   +S+ + +W ++F +++ +VE L N +E F+II+  +N D+ELEE T+ M+SAD  KL+ + ++++ + ++      GIY+  D      + F  +L   FT  ++QIRNNIPC TF I+  + ++   IKS+ FY +FN +SY +FNSSYL RS+ +Y++N+  +     I+L PGF+NIV L+QSRY Y G+ R CRN++F+ +LYD LL   + FEG+Y+ CK++ SQ LFV  C CYSPFLPIY+N TG PR+CLNAT +++ EI++NA+C++ VY +F++    +  +  +C+ Y+ IKC E+ YKI+K  ++FVE WS   N RR+   K +V     +    K+Y   +RD+F+  TI R+   GDLY EE  Y FS+LLSDIGGLMGLWLG+S+VG FEI E  YL+ K  C
Sbjct:    1 MIEILQSSTIHGVSHIHGAKSQITKVLWIFLFIFGIIGIFVNIVFVIIKYFSNPVLISHKLDHEPFIWPDVTFCKPTAPYYFGENSQAYTHWSHVFWRTRRIVERLANETEVFKIINGKRNTDYELEERTIAMSSADPYKLKTNDFRYHIMAIYFNKMQRGIYYHIDNSGIAVTSFAEDLKPLFTAPLVQIRNNIPCFTFHIDKSKFLNQNQIKSISFYLKFNLESYLLFNSSYLHRSVFLYITNRNGIPHKNEILLAPGFNNIVSLSQSRYEYRGVLRKCRNKIFETELYDGLLQSTSTFEGHYDDCKKVESQKLFVGICKCYSPFLPIYKNETGPPRICLNATFYSEDEIVRNAKCMTDVYTKFQSYKAFRNHYRLKCQDYRFIKCNEVKYKIEKDKELFVEFWSGLTNQRRNELLK-KVSYYLMEKFDIKNYFERMRDNFIGITINREFQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFELMYLYLKNLC 502          
BLAST of Degenerin unc-8 vs. Planmine SMEST
Match: SMESG000020604.1 (SMESG000020604.1)

HSP 1 Score: 477.633 bits (1228), Expect = 1.007e-163
Identity = 240/504 (47.62%), Postives = 346/504 (68.65%), Query Frame = 3
Query:   99 MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHMNLDVFFTTRIMQIRNNIPCHTFGINHLESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEMFTKQCKQYKAIKCEELYYKIDKQTDMFVEMWSKSENDRRSSFNKVRVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLFFKASCN 1610
            MIDLIQ+STIHG+ HIYSA  K SK  WC LF  G+  II+NI+F+ +K+FS P  ++Y+ +YEPFIWPDIT CNP  PY  + DSEP+ YW    +Q+K + E +   SE  ++IH   +ND ELEE T+ M++AD +KL A+ +++    + +   H G+YF  +Y+ ++PS F  NL   FT++ +QIRNNIPCHTF ++    +  + I+SLIF ++FN  SYK+FNSSY  +SI +Y++NK ++     I+L PG++NIV LTQ+RY ++G+ RPCR + +K++LY++LL     F GN++ C +I+SQ ++V+NC+CYSPFLPIY+N +GFPRLCLNA++F+ +EIL N +C+   YN F++    K  +  +C++YK I CE + YKID + +M V++WSKS NDRR    K     +F       D+   ++D+ ++  I R   +GDL+ EE  Y F++LLSDIGGLMGLWLGLS+VG FEI+EF YLF K   N
Sbjct:    1 MIDLIQSSTIHGIGHIYSAPGKVSKGLWCILFLFGVVGIIVNIVFVSMKFFSNPVIISYTFEYEPFIWPDITFCNPTDPYAFEIDSEPYLYWIKTLNQTKPIAERVFRESEISQVIHSQNDNDFELEERTIAMSTADPEKLGANGFQNYLTRIGYVKAHRGLYFSKEYQSSSPSKFSENLKPLFTSQTIQIRNNIPCHTFHLDKSRFLSQRRIRSLIFRFKFNEKSYKMFNSSYTFQSIFLYINNKNEIPIENEIILTPGYNNIVQLTQNRYVHNGMRRPCRTKEYKVELYEALLQSTETFFGNFDDCNQITSQRMYVENCHCYSPFLPIYKNESGFPRLCLNASIFSLSEILNNTKCLIDTYNDFQSAPKIKAKYYSECREYKPIPCERISYKIDHRKEMLVDLWSKSANDRRLGIVKQIYYHVFETNETSSDFVHKVKDNIMQLIINRDSEYGDLFKEEREYPFAELLSDIGGLMGLWLGLSVVGLFEIVEFLYLFLKGVFN 504          
BLAST of Degenerin unc-8 vs. Planmine SMEST
Match: SMESG000069546.1 (SMESG000069546.1)

HSP 1 Score: 453.366 bits (1165), Expect = 2.065e-154
Identity = 228/501 (45.51%), Postives = 335/501 (66.87%), Query Frame = 3
Query:   99 MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNP--SDFHMNLDVFFTTRIMQIRNNIPCHTFGINHLESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEMFTKQCKQYKAIKCEELYYKIDKQTDMFVEMWSKSENDRRSSFNKVRVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLFF 1595
            MI+++Q+STIHGV+HI+ AKS+ +K+ W  LF LG+  I +NI+F++++YFS P  ++ ++D+EPFIWPDIT C P APYY   +S+P+ +W  +F +++ +VE L+N +EFF+I++  +N D+ELEE T+ M+SAD  KL+      NF Y    I    I    +Y  +N    +FH +L   FT  ++QI+NNIPC TF IN  +S+H   I S+ F+  FN  SY +FNSS+L RS+ +Y++N+  +     ++L PGF+NIV L+Q+R+ Y G+ R CRN+ +K++LYD+LL   + FEG Y  C ++ SQ L V NC CY+PFLPIY+N TG PR+CLNAT +++ EIL+NA+C+     +FK+  + +  F  +C+ Y+ IKC E+ YKI+K+  +F E+ S     RR    K    K F + +   D+   +RD+++  TIKR+   GDLY EE  Y FSQLLSDIGGLMGLWLG+S+VG FEI E  Y++F
Sbjct:    1 MIEILQSSTIHGVSHIHGAKSRITKMLWIILFILGLIGIFVNIVFVIMRYFSNPVLISRNLDHEPFIWPDITFCKPTAPYYFVENSQPYNHWTEVFRRTRRIVERLSNETEFFKIMNGKRNTDYELEERTIAMSSADPYKLKMD----NFSYHIMLIVFNRIRTYTNYISDNEFFENFHEDLKPLFTAPLVQIQNNIPCFTFHINKSKSLHQDNITSIRFHLNFNIKSYMLFNSSFLHRSVFLYITNRNGIPQKYEMLLEPGFNNIVSLSQNRFEYRGVQRKCRNKTYKVELYDALLQSTSIFEGYYADCMKVESQKLCVSNCKCYNPFLPIYKNETGSPRICLNATFYSEEEILKNAKCMVNRLRKFKSFFLYRRFFNPKCQDYQLIKCNEVKYKIEKEKLLFAELSSGFTTQRRRKVIK-GFSKWFQRIDNRSDFE-RIRDNYIVITIKREFPKGDLYKEEYEYPFSQLLSDIGGLMGLWLGMSVVGLFEIFEIIYMYF 495          
The following BLAST results are available for this feature:
BLAST of Degenerin unc-8 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Degenerin unc-8 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Degenerin unc-8 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Degenerin unc-8 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Degenerin unc-8 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Degenerin unc-8 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Degenerin unc-8 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Degenerin unc-8 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
S5W2R21.047e-14544.56Asic OS=Schmidtea mediterranea OX=79327 PE=2 SV=1[more]
A0A5J4NUF12.117e-7229.94Uncharacterized protein OS=Paragonimus westermani ... [more]
A0A4S2L9139.882e-7131.38Uncharacterized protein OS=Opisthorchis felineus O... [more]
A0A504YRR81.342e-6931.12Degenerin unc-8 OS=Fasciola gigantica OX=46835 GN=... [more]
A0A4E0RSD98.751e-6930.94Degenerin unc-8 OS=Fasciola hepatica OX=6192 GN=D9... [more]
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BLAST of Degenerin unc-8 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Degenerin unc-8 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Degenerin unc-8 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Degenerin unc-8 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO421372.177e-647.73Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO316963.216e-640.30Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Degenerin unc-8 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Degenerin unc-8 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000011525.10.000e+0100.00SMESG000011525.1[more]
SMESG000069054.10.000e+050.30SMESG000069054.1[more]
SMESG000017678.11.991e-16446.32SMESG000017678.1[more]
SMESG000020604.11.007e-16347.62SMESG000020604.1[more]
SMESG000069546.12.065e-15445.51SMESG000069546.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30024562 ID=SMED30024562|Name=Degenerin unc-8|organism=Schmidtea mediterranea sexual|type=transcript|length=1746bp
GAGCTGCTTAATTTGATACGATTGGATAAAACAAACAAATAAAATAATTA
TTTTAATTTCTTGATGATTATAAAATCAGTTTCAATTTTCATTTAGAAAT
GATAGATTTGATTCAAAACAGCACCATTCATGGAGTCAATCACATTTACA
GTGCAAAAAGCAAGTTTTCAAAGCTATTTTGGTGCTTTCTATTTAGCCTA
GGGATATTTGCAATAATTATTAATATAATTTTCATCGTATTGAAATATTT
TTCCTATCCTTTTCAGGTAACTTATTCTATCGACTATGAACCTTTTATTT
GGCCAGATATTACAATTTGTAACCCAGCAGCCCCATATTATTTGCAAAAT
GACTCCGAACCTTTCAAATATTGGAAAAATATCTTTCATCAATCGAAAGA
CGTAGTTGAAACGTTGACTAATTCTTCCGAGTTCTTTCGTATTATTCACA
GAGGTAAAAATAATGATCATGAATTGGAAGAAATAACAGTTACAATGGCA
AGTGCAGATCAACAAAAATTAGAAGCCCATGTTTATAAACATAATTTCAT
ATATGTTCATCATACGATTCCTCATCCGGGAATTTATTTCGTAAATGATT
ATAAAGACAATAATCCTTCAGACTTTCACATGAATTTGGATGTTTTCTTT
ACTACAAGAATAATGCAGATCCGAAACAATATCCCCTGCCATACATTTGG
TATAAATCATTTGGAATCCATGCATCCGAAAACAATTAAATCTCTCATAT
TTTATTACAGATTTAATTATGATAGTTATAAAGTATTCAATTCGAGCTAT
TTAGCAAGATCCATTCTGGTTTACCTCTCTAATAAAGGCCAATTGGCCGC
AAATAAACCCATCGTGTTGCTGCCAGGATTTGATAATATAGTCGGTTTGA
CACAAAGCCGTTACCGTTACAGTGGATTGGGTAGGCCATGTCGAAATGAG
GTTTTTAAAATAAAACTCTACGATTCTCTGCTTACCAGAGTCACAGAATT
TGAAGGCAATTATGAAACATGCAAAGAAATTTCCAGTCAAACCCTTTTCG
TCAAAAACTGCAATTGCTACAGCCCATTTCTGCCAATCTATGAAAATGTC
ACCGGATTTCCAAGATTGTGTTTAAATGCAACTTTGTTTACAAAGGCAGA
AATTCTACAAAATGCCGAATGCATAAGTAAAGTTTATAATAGGTTTAAAA
ATCCAAATATTACTAAAGAAATGTTTACAAAACAATGCAAACAATATAAG
GCAATCAAATGTGAAGAACTGTATTATAAAATAGACAAACAAACAGACAT
GTTTGTTGAAATGTGGTCAAAATCAGAAAATGACAGGCGAAGTAGCTTTA
ATAAGGTGAGAGTTGAGAAGATCTTTGGAAAAGGAAATAAACATAAAGAT
TATCATACTGCACTCCGGGATGACTTCGTTGAATTTACCATCAAAAGACA
AGAAACATTTGGAGACTTGTATGTCGAAGAAAGCGCTTATTCTTTTTCTC
AGTTATTGTCAGATATTGGTGGCTTGATGGGACTGTGGCTTGGATTGAGC
ATCGTTGGATGTTTTGAAATTCTAGAATTCTTTTACTTATTTTTTAAGGC
TTCTTGTAACAATAACCCTGGAACAAAAGATGCCATTCCAAACACAACAA
ATGAAGAGTTCAATGCTTTAAAAATTGTATAATTTTTTCGAACTATTTAT
TTGTCATTTATTAGTTTGAAATTACATTAAATTCGTTTAATTAAAA
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protein sequence of SMED30024562-orf-1

>SMED30024562-orf-1 ID=SMED30024562-orf-1|Name=SMED30024562-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=528bp
MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGIFAIIINIIFIVLKY
FSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSK
DVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNF
IYVHHTIPHPGIYFVNDYKDNNPSDFHMNLDVFFTTRIMQIRNNIPCHTF
GINHLESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLA
ANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTE
FEGNYETCKEISSQTLFVKNCNCYSPFLPIYENVTGFPRLCLNATLFTKA
EILQNAECISKVYNRFKNPNITKEMFTKQCKQYKAIKCEELYYKIDKQTD
MFVEMWSKSENDRRSSFNKVRVEKIFGKGNKHKDYHTALRDDFVEFTIKR
QETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLFFK
ASCNNNPGTKDAIPNTTNEEFNALKIV*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR001873ENaC
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: biological process
TermDefinition
GO:0006814sodium ion transport
GO:0006810transport
GO:0006811ion transport
GO:0035725sodium ion transmembrane transport
Vocabulary: molecular function
TermDefinition
GO:0005272sodium channel activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001873Epithelial sodium channelPRINTSPR01078AMINACHANNELcoord: 64..80
score: 27.29
coord: 474..490
score: 45.41
coord: 314..331
score: 32.44
coord: 460..474
score: 42.13
IPR001873Epithelial sodium channelPFAMPF00858ASCcoord: 6..494
e-value: 3.8E-45
score: 154.7
IPR001873Epithelial sodium channelPANTHERPTHR11690AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATEDcoord: 7..505
NoneNo IPR availableGENE3DG3DSA:1.10.287.770coord: 25..492
e-value: 4.0E-25
score: 90.6
NoneNo IPR availableGENE3DG3DSA:1.10.3590.10coord: 77..238
e-value: 4.0E-25
score: 90.6
NoneNo IPR availableGENE3DG3DSA:2.60.470.10coord: 55..462
e-value: 4.0E-25
score: 90.6
NoneNo IPR availableGENE3DG3DSA:1.10.287.820coord: 274..388
e-value: 4.0E-25
score: 90.6
NoneNo IPR availablePANTHERPTHR11690:SF222PICKPOCKET 6-RELATEDcoord: 7..505
NoneNo IPR availableTMHMMTMhelixcoord: 26..48
NoneNo IPR availableTMHMMTMhelixcoord: 477..499