Degenerin unc-8
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30024562 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 4
Homology
BLAST of Degenerin unc-8 vs. TrEMBL
Match: S5W2R2 (Asic OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 439.499 bits (1129), Expect = 1.047e-145 Identity = 221/496 (44.56%), Postives = 338/496 (68.15%), Query Frame = 3 Query: 99 MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHMNLDVFFTTRIMQIRNNIPCHTFGINHLESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEMFTKQCKQYKAIKCEELYYKIDKQTDMFVEMWSKSENDRRSSFNKVRVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFY 1586 MIDLIQ+STIHG+ HI+SA +K K+ WC LF +G+ AII+NI+FI +K+ S P ++Y+ ++EPFIWPDIT CNP PY +S+P+ +W +++K V + + ++IH + ND+ELEE T+ M+SAD KL+A +++ + + H G+YF +++ ++ + + + FT++I+Q+RNNIPCHTF ++ + K IKSL+F ++ N +SYK+FNSSY +S+ +Y+SNK ++ + I+L PG++N+V LTQ+R+ Y+GL R CRNE F+ +LYDSLL ++ G+Y+ CK+I SQ +VK CNCY+ FLPI++N +GFPRLCLNA++F++AE+L+NA+C+ + ++ + + F +CK Y+ I C ++ YKID + ++ V++WSKS NDRR K K F D+ ++D+ ++ I R GDLY EE Y FS+LLSD+GGLMGLWLGLS++G FEI+EF Y Sbjct: 1 MIDLIQSSTIHGIGHIFSATNKIFKVLWCILFLVGVIAIIVNIVFISMKFLSNPVIISYTFEHEPFIWPDITFCNPTDPYAFTINSQPYLHWIETLNKTKRVAGKVARQTSMSQLIHSRRENDYELEERTIAMSSADPAKLQATAFQNYLYRIGYIKAHKGLYFSKEFQSSS-TKLNEDWKSLFTSQIVQMRNNIPCHTFHLDKSRIVKQKFIKSLLFRFKLNEESYKIFNSSYTFQSMFLYISNKDEIPQSNEIILTPGYNNVVQLTQNRHSYTGLRRTCRNEKFEAELYDSLLQSTEKYSGSYDDCKKIVSQQKYVKYCNCYNSFLPIFKNSSGFPRLCLNASIFSEAEVLKNAKCMINTFRKYAESDKARRRFYNRCKMYRPIPCNKVLYKIDHRKEILVDLWSKSTNDRRREIIKTLYLKTFQTNETSLDFVEKVKDNIMQLIINRDNESGDLYKEEREYPFSELLSDVGGLMGLWLGLSVIGLFEIVEFVY 495
BLAST of Degenerin unc-8 vs. TrEMBL
Match: A0A5J4NUF1 (Uncharacterized protein OS=Paragonimus westermani OX=34504 GN=DEA37_0013022 PE=3 SV=1) HSP 1 Score: 255.373 bits (651), Expect = 2.117e-72 Identity = 159/531 (29.94%), Postives = 277/531 (52.17%), Query Frame = 3 Query: 87 FHLEMIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFI-YVHHTIPHPGIYFVNDYKDNNPSDFHMN--LDVFFTTRIMQIRNNIPCHTFGINH-LESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLP---IYEN--VTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEM-FTKQCKQYKAIKCEELYYKI-DKQTDMFVEMWSKSENDRRSSFNKVRVEKIFG----------------KGNKHKDYHTA------LRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEF 1580 FH+ + L+++ST+HG++H+ +A +K ++ W L GI N+ FI+ +Y + P +Y +YE FIWPDIT+CN APY L K W+ + +Q+ + L +S F I N+ ++ + + S + + FI +V + + GI + N H+N L +F T+++Q R N+PC+T + H L ++ + S+ +FN +SY++ NSSY + I +++S+ G + PI +LPG+ + L SR R CR + + +++D L G+ C I SQ L++ +C+CYSPFLP +Y + + LC N + F+ A+I +NA+C+ ++Y R++ ++ + + C+Q++ C+++ YK+ D + VE+WS S N+ R +F + +F K + KD + +RD+F ++ R+ G+L EE Y S+L+SD+GGLMGLW+G+S++G FEI+E Sbjct: 23 FHVGVERLLEHSTVHGLSHVSTAATKLGRITWFCLLLAGIAGFFTNLSFIIDRYLTRPVLTSYISEYEGFIWPDITLCNAMAPYSLHLHGRIPK-WQALRNQASAFAQKLNSS--LFASIDSQDQNEIAIQALMYSTLSPPEYGVGE---PEEFIQFVATDVGYQGIILTVEISGNMT---HLNPPLKKYFHTQVLQKRYNVPCYTLQLRHSLTAVQSNQVNSIGLGVKFNVESYRIINSSYASPYIDLFISHPGHAPHDDPIEMLPGYTLSLSLRMSRLRREPARLSCRTDFYTTEVFDPDLVTKRRVNGSATFCHRIVSQHLYLNSCHCYSPFLPYPVVYNHKLFSKMAILCFNMSRFSVAQINRNADCMLRIYERYQLSSVYNSVPEARACEQFRKPLCDDVEYKLSDIRRTAMVELWSNSYNEARIAFLTSSFQNLFSSDIPPEQLVSWLDSDTKDDNTKDNDSMPKILKYMRDNFGLLSVNRKSELGELVREELEYPLSELMSDVGGLMGLWIGISVIGLFEIVEL 544
BLAST of Degenerin unc-8 vs. TrEMBL
Match: A0A4S2L913 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_009406 PE=3 SV=1) HSP 1 Score: 250.366 bits (638), Expect = 9.882e-71 Identity = 166/529 (31.38%), Postives = 278/529 (52.55%), Query Frame = 3 Query: 87 FHLEMIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEIT-VTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHMNLDVFFTTRIMQIRNNIPCHTFGINH-LESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPI-----YENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNP----NITKEMFTKQCKQYKAI-KCEELYYKI--DKQTDMFVEMWSKSENDRRSSFNKV-------------RVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLF 1592 FH+ L+++ST+HG++H+ SA S ++ W LF GI IN+ IV +Y S P + D++ F+WPDITICNP+APY + K W + +K+V + + SE F I + + + + TM+ +D + +V H GI + D N + ++ +F T I+Q R NIPC+T I + K ++ + +FN +S+ + N+SY++ ++ +S G + ++PI LLPG+ + +GL R++ RPCRN VF ++++D+ L G+ C I SQ L++K C CYSPFLP + + P LC N + F ++ QNA+C+ + ++++P NI + ++C+ ++ CE++ +++ ++T ++ E+WS+ ND R SF K R+ K F N + LR++F TI+R+ G+L E+ Y ++LLSDIGGLMGLW+G+S++G FE+LE L Sbjct: 65 FHVNARRLLEHSTVHGLSHVSSASSHVGRITWFVLFVAGITGFCINLSLIVSRYVSRPVLTSIFNDHDDFVWPDITICNPSAPYVVHLYDRHEK-WLRLRDWAKNVAQYI--PSELFAAIDEADKVEIKTQALMHSTMSPSD---FGVGIPNETVNFVAADTGHYGIVLTVEL-DGNLTYLSAPMEQYFRTHILQKRYNIPCYTLQIEQGMPEDERKRVRKVALGLKFNIESHMIINTSYVSPTLDFIISRPGHMPHDEPIELLPGYMHYIGLNFQRFKREPSKRPCRNNVFDVEVFDANLATKYPVHGSATLCHRILSQNLYIKYCGCYSPFLPYPVIPSHPDFDDSPVLCFNMSRFKIEQLNQNAKCMFNLLEKYRDPVTYMNIPE---ARECEYLGSVPPCEDIEHQLIQTRRTPLW-ELWSEKYNDARLSFLKAAFQLVFEVDIVQNRLGKSFHINNDSEPALRYLRENFALITIERKVEKGELIREDLEYPLAELLSDIGGLMGLWIGISVIGLFEVLELLGLM 582
BLAST of Degenerin unc-8 vs. TrEMBL
Match: A0A504YRR8 (Degenerin unc-8 OS=Fasciola gigantica OX=46835 GN=FGIG_05554 PE=3 SV=1) HSP 1 Score: 248.825 bits (634), Expect = 1.342e-69 Identity = 169/543 (31.12%), Postives = 279/543 (51.38%), Query Frame = 3 Query: 87 FHLEMIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPY--YLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHM---------NLDV----FFTTRIMQIRNNIPCHTFGINH-LESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFL---------PIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNP----NITKEMFTKQCKQYKAI-KCEELYYKIDK-QTDMFVEMWSKSENDRRSSFNKVRVEKIFGKG----------NKHKDYHTAL---RDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFF 1583 F+L + L+++ST+HG++H+ +A ++ + W L+ G+ N+ FIV +Y + P +Y D+E FIWPDIT+CNP APY +L N SE + N+ HQ V + + F I ++ E EE+TV Q + + V F PH ++FV D + H+ NLD+ +F +++Q R NIPC+T ++ L + K + +FN+DS + NSSY +I +++S G + ++P+ +L G+ + V +T R+ PCR E F +++D+ L E G+ + C ++ SQ L++ +C CYSPFL P+Y++ P LC N + F + I +NA C+ +VY +FK N+ + F C+ ++A CE + Y ++ + +E W+ + N+ RS+F E +FG+ N + + L R++F I R+ G L EE Y S+LLSD+GGLMGLW+G+S++G FE++E F Sbjct: 27 FYLGVRRLLEHSTVHGLSHVSTASTRIGRSVWLILWMAGVAGFFTNLSFIVSRYMTRPVLTSYKHDHELFIWPDITLCNPMAPYPVHLNNRSEKW----NLLHQLATAVSRNISGNLFATI------DEAEQEEVTV------QALIHSTVSPMEF---GANDPHELVHFV--AVDKGQTGIHLTIEMDATFTNLDIPKHRYFHVQVLQKRYNIPCYTLRLDQVLNEEECASTKQVSLGLKFNHDSNLIINSSYAPFNIDLFISLPGHMPEDEPMEILSGYSHKVTVTMGRFTRERTRLPCRTEQFVTQVFDADLKTQREVVGSADFCLKLLSQRLYIDHCGCYSPFLPYPVMGQDHPLYQH----PVLCFNMSHFNASGIDRNARCMYEVYTQFKEDFIYMNLPEAGF---CETFRATPPCESINYVLESPRRTPIIEFWADTVNEARSAFVTSTFESVFGQDLPEERLKQMVNNSGNTSSLLFYMRNNFGLVKITRKLPRGTLTHEELEYPLSELLSDVGGLMGLWVGISVIGLFEVVELF 541
BLAST of Degenerin unc-8 vs. TrEMBL
Match: A0A4E0RSD9 (Degenerin unc-8 OS=Fasciola hepatica OX=6192 GN=D915_000009 PE=3 SV=1) HSP 1 Score: 246.514 bits (628), Expect = 8.751e-69 Identity = 168/543 (30.94%), Postives = 277/543 (51.01%), Query Frame = 3 Query: 87 FHLEMIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPY--YLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHM---------NLDV----FFTTRIMQIRNNIPCHTFGINH-LESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFL---------PIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNP----NITKEMFTKQCKQYKAI-KCEELYYKIDK-QTDMFVEMWSKSENDRRSSFNKVRVEKIFGKG----------NKHKDYHTAL---RDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFF 1583 F+L + L+++ST+HG++H+ +A ++ + W L+ G+ N+ FIV +Y + P +Y D+E FIWPDIT+CNP APY +L N SE + N+ HQ V + + F I ++ E EE+TV Q + + V F PH ++FV D + H+ NLD+ +F +++Q R NIPC+T ++ L + K + +FN+DS + NSSY +I +++S G + ++P+ +L G+ + V +T R+ PCR E F +++D+ L E G+ + C ++ SQ L++ +C CYSPFL P+Y+ P LC N + F + I +NA C+ VY +FK N+ + + C+ ++A CE + Y ++ + +E W+ + N+ RS+F E +FG+ N + + L R++F I R+ G L EE Y S+LLSD+GGLMGLW+G+S++G FE++E F Sbjct: 27 FYLGVRRLLEHSTVHGLSHVSTAGTRIGRSVWLILWMAGVAGFFTNLSFIVSRYMTRPVLTSYKHDHELFIWPDITLCNPMAPYPVHLNNRSEKW----NLLHQLATAVSRNISGNLFATI------DEAEQEEVTV------QALIHSTVSPMEF---GANDPHELVHFV--AVDKGQTGIHLTIEMDATFTNLDIPKHRYFHVQVLQKRYNIPCYTLRLDQVLNEEECASTKQVSLGLKFNHDSNLIINSSYAPFNIDLFISLPGHMPEDEPMEILSGYSHKVTVTMGRFTRERTRLPCRTEQFVTQVFDADLKTQREVVGSADFCLKLLSQRLYIDHCGCYSPFLPYPVMGQDHPLYQQ----PVLCFNMSHFNASGIDRNARCMYDVYTQFKEDFVYMNLPEAGY---CETFRATPPCESINYVLESPRRTPIIEFWADTVNEARSAFVTSTFESVFGQDLPEERLKQMVNNSGNTSSLLFYMRNNFGLVKITRKLPRGTLTHEELEYPLSELLSDVGGLMGLWVGISVIGLFEVVELF 541
BLAST of Degenerin unc-8 vs. Ensembl Nematostella
Match: EDO42137 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2F2]) HSP 1 Score: 50.0618 bits (118), Expect = 2.177e-6 Identity = 21/44 (47.73%), Postives = 31/44 (70.45%), Query Frame = 3 Query: 1467 LYVEES-AYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLFF 1595 L V+E+ AY+F LLSDIGG MG+W+G+S + C E++E + Sbjct: 446 LLVQETLAYTFMSLLSDIGGQMGMWIGISALTCAELIELVCVIL 489
BLAST of Degenerin unc-8 vs. Ensembl Nematostella
Match: EDO31696 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX71]) HSP 1 Score: 49.2914 bits (116), Expect = 3.216e-6 Identity = 27/67 (40.30%), Postives = 42/67 (62.69%), Query Frame = 3 Query: 1413 LRDDFVEFTIKRQETFGDLYVEES-AYSFSQLLSDIGGLMGLWLGLSIVGCFEILEF-FYLFFKASC 1607 RD+++E I +E + ++EES AY LSDIGG +GLW+G+S++ E++E +FFK C Sbjct: 335 FRDNYLEVNIFFKEL--NYFIEESVAYELVNFLSDIGGQLGLWVGVSVMTGAEVVELALLIFFKVFC 399
BLAST of Degenerin unc-8 vs. Planmine SMEST
Match: SMESG000011525.1 (SMESG000011525.1) HSP 1 Score: 1070.07 bits (2766), Expect = 0.000e+0 Identity = 527/527 (100.00%), Postives = 527/527 (100.00%), Query Frame = 3 Query: 99 MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHMNLDVFFTTRIMQIRNNIPCHTFGINHLESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEMFTKQCKQYKAIKCEELYYKIDKQTDMFVEMWSKSENDRRSSFNKVRVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLFFKASCNNNPGTKDAIPNTTNEEFNALKIV 1679 MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGIFAIIINIIFIVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHMNLDVFFTTRIMQIRNNIPCHTFGINHLESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEMFTKQCKQYKAIKCEELYYKIDKQTDMFVEMWSKSENDRRSSFNKVRVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLFFKASCNNNPGTKDAIPNTTNEEFNALKIV Sbjct: 1 MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGIFAIIINIIFIVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHMNLDVFFTTRIMQIRNNIPCHTFGINHLESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEMFTKQCKQYKAIKCEELYYKIDKQTDMFVEMWSKSENDRRSSFNKVRVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLFFKASCNNNPGTKDAIPNTTNEEFNALKIV 527
BLAST of Degenerin unc-8 vs. Planmine SMEST
Match: SMESG000069054.1 (SMESG000069054.1) HSP 1 Score: 523.857 bits (1348), Expect = 0.000e+0 Identity = 254/505 (50.30%), Postives = 358/505 (70.89%), Query Frame = 3 Query: 99 MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHMNLDVFFTTRIMQIRNNIPCHTFGINHLESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEMFTKQCKQYKAIKCEELYYKIDKQTDMFVEMWSKSENDRRSSFNKVRVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLFFKASCNN 1613 MI+L+++STIHG+NHIYSA K +K WC LF GI II+NI F+ ++YFSYP ++Y+ ++EPF+WPDIT CNP AP+YL S+ +KYW I +QS+DVV+ L ++ F+II K D ELEE T+ MAS++ KL A +++++ +V +T PH GIYF D ++NNP F +L F+T+I+QI+NNIPCHTF ++ ++P +++SL+F RFNYDSY++FNSSY RSI +Y+SN+ ++ ++ I L PGF+NI+ L+Q+R+ Y+GL R CR++ FK ++YD+L V FEG+YE CK+I SQ LFV C CYSPFLPI++N TGFPRLCLNAT F+K ++L+NA+C+ VY FK ++ + QC +K KC+ L Y++D + DM VE+WSK N +R + K FGK KD++ +RD+ V+ I+R+ + DL+ EE Y FS+LLSDIGGLMGLWLG+S+VG FEILEFFYLF +C N Sbjct: 1 MIELVKSSTIHGINHIYSANGKLAKFLWCVLFIFGIIGIIVNICFVSIRYFSYPVLISYTFEHEPFVWPDITFCNPTAPFYLDRKSKAYKYWMQINNQSRDVVKMLVKETKLFQIIRESKETDFELEERTIAMASSNPVKLGADLFENHVKFVGYTRPHSGIYFNKDIQNNNPKTFPGDLKPLFSTQIVQIQNNIPCHTFHMHKSNILNPNSVQSLVFGLRFNYDSYEIFNSSYTTRSIFLYISNRDEIQQDQNIFLSPGFNNILSLSQNRHHYNGLRRKCRHKTFKFEVYDALFQNVKTFEGSYEDCKQIVSQRLFVDKCKCYSPFLPIFKNQTGFPRLCLNATFFSKTKLLENAKCMVNVYENFKKSGNFRKHYNNQCLIFKLHKCDLLSYQMDLRKDMLVELWSKVYNGKRLNSIKFMHSYYFGKNESKKDFNEVMRDNIVDLIIERKFEYSDLFKEEREYPFSELLSDIGGLMGLWLGMSVVGLFEILEFFYLFSINACLN 505
BLAST of Degenerin unc-8 vs. Planmine SMEST
Match: SMESG000017678.1 (SMESG000017678.1) HSP 1 Score: 479.174 bits (1232), Expect = 1.991e-164 Identity = 233/503 (46.32%), Postives = 345/503 (68.59%), Query Frame = 3 Query: 99 MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHMNLDVFFTTRIMQIRNNIPCHTFGINHLESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEMFTKQCKQYKAIKCEELYYKIDKQTDMFVEMWSKSENDRRSSFNKVRVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLFFKASC 1607 MI+++Q+STIHGV+HI+ AKS+ +K+ W FLF GI I +NI+F+++KYFS P +++ +D+EPFIWPD+T C P APYY +S+ + +W ++F +++ +VE L N +E F+II+ +N D+ELEE T+ M+SAD KL+ + ++++ + ++ GIY+ D + F +L FT ++QIRNNIPC TF I+ + ++ IKS+ FY +FN +SY +FNSSYL RS+ +Y++N+ + I+L PGF+NIV L+QSRY Y G+ R CRN++F+ +LYD LL + FEG+Y+ CK++ SQ LFV C CYSPFLPIY+N TG PR+CLNAT +++ EI++NA+C++ VY +F++ + + +C+ Y+ IKC E+ YKI+K ++FVE WS N RR+ K +V + K+Y +RD+F+ TI R+ GDLY EE Y FS+LLSDIGGLMGLWLG+S+VG FEI E YL+ K C Sbjct: 1 MIEILQSSTIHGVSHIHGAKSQITKVLWIFLFIFGIIGIFVNIVFVIIKYFSNPVLISHKLDHEPFIWPDVTFCKPTAPYYFGENSQAYTHWSHVFWRTRRIVERLANETEVFKIINGKRNTDYELEERTIAMSSADPYKLKTNDFRYHIMAIYFNKMQRGIYYHIDNSGIAVTSFAEDLKPLFTAPLVQIRNNIPCFTFHIDKSKFLNQNQIKSISFYLKFNLESYLLFNSSYLHRSVFLYITNRNGIPHKNEILLAPGFNNIVSLSQSRYEYRGVLRKCRNKIFETELYDGLLQSTSTFEGHYDDCKKVESQKLFVGICKCYSPFLPIYKNETGPPRICLNATFYSEDEIVRNAKCMTDVYTKFQSYKAFRNHYRLKCQDYRFIKCNEVKYKIEKDKELFVEFWSGLTNQRRNELLK-KVSYYLMEKFDIKNYFERMRDNFIGITINREFQKGDLYKEEYEYPFSELLSDIGGLMGLWLGMSVVGLFEIFELMYLYLKNLC 502
BLAST of Degenerin unc-8 vs. Planmine SMEST
Match: SMESG000020604.1 (SMESG000020604.1) HSP 1 Score: 477.633 bits (1228), Expect = 1.007e-163 Identity = 240/504 (47.62%), Postives = 346/504 (68.65%), Query Frame = 3 Query: 99 MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNPSDFHMNLDVFFTTRIMQIRNNIPCHTFGINHLESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEMFTKQCKQYKAIKCEELYYKIDKQTDMFVEMWSKSENDRRSSFNKVRVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLFFKASCN 1610 MIDLIQ+STIHG+ HIYSA K SK WC LF G+ II+NI+F+ +K+FS P ++Y+ +YEPFIWPDIT CNP PY + DSEP+ YW +Q+K + E + SE ++IH +ND ELEE T+ M++AD +KL A+ +++ + + H G+YF +Y+ ++PS F NL FT++ +QIRNNIPCHTF ++ + + I+SLIF ++FN SYK+FNSSY +SI +Y++NK ++ I+L PG++NIV LTQ+RY ++G+ RPCR + +K++LY++LL F GN++ C +I+SQ ++V+NC+CYSPFLPIY+N +GFPRLCLNA++F+ +EIL N +C+ YN F++ K + +C++YK I CE + YKID + +M V++WSKS NDRR K +F D+ ++D+ ++ I R +GDL+ EE Y F++LLSDIGGLMGLWLGLS+VG FEI+EF YLF K N Sbjct: 1 MIDLIQSSTIHGIGHIYSAPGKVSKGLWCILFLFGVVGIIVNIVFVSMKFFSNPVIISYTFEYEPFIWPDITFCNPTDPYAFEIDSEPYLYWIKTLNQTKPIAERVFRESEISQVIHSQNDNDFELEERTIAMSTADPEKLGANGFQNYLTRIGYVKAHRGLYFSKEYQSSSPSKFSENLKPLFTSQTIQIRNNIPCHTFHLDKSRFLSQRRIRSLIFRFKFNEKSYKMFNSSYTFQSIFLYINNKNEIPIENEIILTPGYNNIVQLTQNRYVHNGMRRPCRTKEYKVELYEALLQSTETFFGNFDDCNQITSQRMYVENCHCYSPFLPIYKNESGFPRLCLNASIFSLSEILNNTKCLIDTYNDFQSAPKIKAKYYSECREYKPIPCERISYKIDHRKEMLVDLWSKSANDRRLGIVKQIYYHVFETNETSSDFVHKVKDNIMQLIINRDSEYGDLFKEEREYPFAELLSDIGGLMGLWLGLSVVGLFEIVEFLYLFLKGVFN 504
BLAST of Degenerin unc-8 vs. Planmine SMEST
Match: SMESG000069546.1 (SMESG000069546.1) HSP 1 Score: 453.366 bits (1165), Expect = 2.065e-154 Identity = 228/501 (45.51%), Postives = 335/501 (66.87%), Query Frame = 3 Query: 99 MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGXXXXXXXXXXXVLKYFSYPFQVTYSIDYEPFIWPDITICNPAAPYYLQNDSEPFKYWKNIFHQSKDVVETLTNSSEFFRIIHRGKNNDHELEEITVTMASADQQKLEAHVYKHNFIYVHHTIPHPGIYFVNDYKDNNP--SDFHMNLDVFFTTRIMQIRNNIPCHTFGINHLESMHPKTIKSLIFYYRFNYDSYKVFNSSYLARSILVYLSNKGQLAANKPIVLLPGFDNIVGLTQSRYRYSGLGRPCRNEVFKIKLYDSLLTRVTEFEGNYETCKEISSQTLFVKNCNCYSPFLPIYENVTGFPRLCLNATLFTKAEILQNAECISKVYNRFKNPNITKEMFTKQCKQYKAIKCEELYYKIDKQTDMFVEMWSKSENDRRSSFNKVRVEKIFGKGNKHKDYHTALRDDFVEFTIKRQETFGDLYVEESAYSFSQLLSDIGGLMGLWLGLSIVGCFEILEFFYLFF 1595 MI+++Q+STIHGV+HI+ AKS+ +K+ W LF LG+ I +NI+F++++YFS P ++ ++D+EPFIWPDIT C P APYY +S+P+ +W +F +++ +VE L+N +EFF+I++ +N D+ELEE T+ M+SAD KL+ NF Y I I +Y +N +FH +L FT ++QI+NNIPC TF IN +S+H I S+ F+ FN SY +FNSS+L RS+ +Y++N+ + ++L PGF+NIV L+Q+R+ Y G+ R CRN+ +K++LYD+LL + FEG Y C ++ SQ L V NC CY+PFLPIY+N TG PR+CLNAT +++ EIL+NA+C+ +FK+ + + F +C+ Y+ IKC E+ YKI+K+ +F E+ S RR K K F + + D+ +RD+++ TIKR+ GDLY EE Y FSQLLSDIGGLMGLWLG+S+VG FEI E Y++F Sbjct: 1 MIEILQSSTIHGVSHIHGAKSRITKMLWIILFILGLIGIFVNIVFVIMRYFSNPVLISRNLDHEPFIWPDITFCKPTAPYYFVENSQPYNHWTEVFRRTRRIVERLSNETEFFKIMNGKRNTDYELEERTIAMSSADPYKLKMD----NFSYHIMLIVFNRIRTYTNYISDNEFFENFHEDLKPLFTAPLVQIQNNIPCFTFHINKSKSLHQDNITSIRFHLNFNIKSYMLFNSSFLHRSVFLYITNRNGIPQKYEMLLEPGFNNIVSLSQNRFEYRGVQRKCRNKTYKVELYDALLQSTSIFEGYYADCMKVESQKLCVSNCKCYNPFLPIYKNETGSPRICLNATFYSEEEILKNAKCMVNRLRKFKSFFLYRRFFNPKCQDYQLIKCNEVKYKIEKEKLLFAELSSGFTTQRRRKVIK-GFSKWFQRIDNRSDFE-RIRDNYIVITIKREFPKGDLYKEEYEYPFSQLLSDIGGLMGLWLGMSVVGLFEIFEIIYMYF 495 The following BLAST results are available for this feature:
BLAST of Degenerin unc-8 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Degenerin unc-8 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Degenerin unc-8 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Degenerin unc-8 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Degenerin unc-8 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Degenerin unc-8 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Degenerin unc-8 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Degenerin unc-8 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Degenerin unc-8 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Degenerin unc-8 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Degenerin unc-8 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Degenerin unc-8 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 2
BLAST of Degenerin unc-8 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Degenerin unc-8 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30024562 ID=SMED30024562|Name=Degenerin unc-8|organism=Schmidtea mediterranea sexual|type=transcript|length=1746bpback to top protein sequence of SMED30024562-orf-1 >SMED30024562-orf-1 ID=SMED30024562-orf-1|Name=SMED30024562-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=528bp MIDLIQNSTIHGVNHIYSAKSKFSKLFWCFLFSLGIFAIIINIIFIVLKYback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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