Cyclin-dependent kinase

Overview
NameCyclin-dependent kinase
Smed IDSMED30024555
Length (bp)1199
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Cyclin-dependent kinase (SMED30024555) t-SNE clustered cells

Violin plots show distribution of expression levels for Cyclin-dependent kinase (SMED30024555) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cyclin-dependent kinase (SMED30024555) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Cyclin-dependent kinase (SMED30024555) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30024555

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30024555SMESG000023609.1 SMESG000023590.1 SmedASXL_014258SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30024555SMESG000023609.1 SMESG000023590.1 SmedASXL_014258SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
zeta neoblastSMED30024555SMESG000023609.1 SMESG000023590.1 dd_Smed_v4_14134_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
neoblastSMED30024555SMESG000023609.1 SMESG000023590.1 SMED30024555smed_20140614PMID:27523733
Lei et al., 2016
whole organism asexual adult colorimetric in situ hybridization evidence
neoblastSMED30024555SMESG000023609.1 SMED_26757_V2_1GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30024555SMESG000023609.1 SMED_26757_V2_1GPL14150PMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30024555SMESG000023609.1 SMESG000023590.1 SMED_07692_V2_1GPL14150PMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Cyclin-dependent kinase vs. Ensembl Human
Match: CDK1 (cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722])

HSP 1 Score: 228.794 bits (582), Expect = 6.722e-72
Identity = 125/299 (41.81%), Postives = 181/299 (60.54%), Query Frame = 1
Query:  127 DYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIK--LLKTKV---NSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSV 981
            DY  + K+G  +YG VY  ++K    + A+KK++++   EG+P+T +REISLLK L+HPNI++L  VL+ D R+Y+I E++ M L  +L        + S+L++S+++Q+LQ   FCH+RRVLHRD+K QN+L++    I KL DFGL+R  G      T  VVTL+YRSPE++L    Y + VDIWS+G +F E+  K P F  D EI   F  F  LG PN++  P      E  + Q+ KN+F   K   L + V   +    DL+ +M IY+P KRI    AL H YF+D D  +
Sbjct:    3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI-KLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP------EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294          
BLAST of Cyclin-dependent kinase vs. Ensembl Human
Match: CDK1 (cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722])

HSP 1 Score: 226.868 bits (577), Expect = 3.889e-71
Identity = 123/299 (41.14%), Postives = 180/299 (60.20%), Query Frame = 1
Query:  127 DYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIK--LLKTKV---NSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSV 981
            DY  + K+G  +YG VY  ++K    + A+KK++++   EG+P+T +REISLLK L+HPNI++L  VL+ D R+Y+I E++ M L  +L        + S+L++S+++Q+LQ   FCH+RRVLHRD+K QN+L++    I KL DFGL+R  G      T   +TL+YRSPE++L    Y + VDIWS+G +F E+  K P F  D EI   F  F  LG PN++  P      E  + Q+ KN+F   K   L + V   +    DL+ +M IY+P KRI    AL H YF+D D  +
Sbjct:    3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI-KLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP------EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294          
BLAST of Cyclin-dependent kinase vs. Ensembl Human
Match: CDK3 (cyclin dependent kinase 3 [Source:HGNC Symbol;Acc:HGNC:1772])

HSP 1 Score: 223.016 bits (567), Expect = 1.198e-69
Identity = 115/284 (40.49%), Postives = 174/284 (61.27%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSS---NLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVA 984
            G+YG VY AKN++   L ALKK+++D   EG+P+T +REISLLK L+HPNI+ L  V+ +++++Y++ E++   L  ++     S    +L++S++FQLLQ  +FCH+ RV+HRD+K QN+L+N  +  +KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VDIWS+GC+F EMV +   F  D EI   F  F  LG P++D  PG   +         K +   ++ +   +  +  DL+MQ+  Y+P +RI A  AL H YF   + S A
Sbjct:   13 GTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGV-TQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPA 294          
BLAST of Cyclin-dependent kinase vs. Ensembl Human
Match: CDK3 (cyclin dependent kinase 3 [Source:HGNC Symbol;Acc:HGNC:1772])

HSP 1 Score: 223.016 bits (567), Expect = 1.198e-69
Identity = 115/284 (40.49%), Postives = 174/284 (61.27%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSS---NLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVA 984
            G+YG VY AKN++   L ALKK+++D   EG+P+T +REISLLK L+HPNI+ L  V+ +++++Y++ E++   L  ++     S    +L++S++FQLLQ  +FCH+ RV+HRD+K QN+L+N  +  +KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VDIWS+GC+F EMV +   F  D EI   F  F  LG P++D  PG   +         K +   ++ +   +  +  DL+MQ+  Y+P +RI A  AL H YF   + S A
Sbjct:   13 GTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGV-TQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPA 294          
BLAST of Cyclin-dependent kinase vs. Ensembl Human
Match: CDK2 (cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771])

HSP 1 Score: 213.386 bits (542), Expect = 6.528e-66
Identity = 116/285 (40.70%), Postives = 171/285 (60.00%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSS---NLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKV--KFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSV 981
            G+YG VY A+NK    + ALKK+++D   EG+P+T +REISLLK L HPNI+ L  V+ ++ ++Y++ E++   L  F+    ++     L++S++FQLLQ  AFCH+ RVLHRD+K QN+L+N +   +KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VDIWSLGC+F EMV +   F  D EI   F  F  LG P++   PG      ++    + ++  F+ +      ++     L+ QM  Y+P KRI A AAL H +F D  + V
Sbjct:   13 GTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKV---VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293          
BLAST of Cyclin-dependent kinase vs. Ensembl Celegans
Match: cdk-1 (Cyclin-dependent kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:P34556])

HSP 1 Score: 229.18 bits (583), Expect = 4.781e-72
Identity = 123/316 (38.92%), Postives = 187/316 (59.18%), Query Frame = 1
Query:   97 DIPHQ---LYRIGDYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKI---DEGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFL----RDFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPND------DDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPA 990
            ++ H+   +Y + D+  L K+G  +YG VY  KN++   + A+KK+++   DEG+P+T +REISLLK LQHPN++ L  V++ + R+++I E++   L  ++    +D  +    L+S+ FQ+LQA  FCH RRV+HRD+K QN+LV+++  I KL DFGL+R IG      T  VVTL+YR+PE+++    Y  GVD+WS+GC+F EM  K P F+ D EI   F  F  LG P +      + +P  K  F        ++ F   K  K  ++   F L+  + IY+P  R+ A  AL+H YF + D S  PA
Sbjct:    8 EVAHEGDSVYTLNDFTKLEKIGEGTYGVVYKGKNRRTNAMVAMKKIRLESEDEGVPSTAVREISLLKELQHPNVVGLEAVIMQENRLFLIFEFLSFDLKRYMDQLGKDEYLPLETLKSYTFQILQAMCFCHQRRVIHRDLKPQNLLVDNNGAI-KLADFGLARAIGIPIRVYTHEVVTLWYRAPEILMGAQRYSMGVDMWSIGCIFAEMATKKPLFQGDSEIDELFRIFRVLGTPTELEWNGVESLPDYKATFPKWRENFLRDKFYDKKTGKHLLDDTAFSLLEGLLIYDPSLRLNAKKALVHPYFDNMDTSKLPA 322          
BLAST of Cyclin-dependent kinase vs. Ensembl Celegans
Match: cdk-1 (Cyclin-dependent kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:P34556])

HSP 1 Score: 229.18 bits (583), Expect = 4.781e-72
Identity = 123/316 (38.92%), Postives = 187/316 (59.18%), Query Frame = 1
Query:   97 DIPHQ---LYRIGDYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKI---DEGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFL----RDFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPND------DDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPA 990
            ++ H+   +Y + D+  L K+G  +YG VY  KN++   + A+KK+++   DEG+P+T +REISLLK LQHPN++ L  V++ + R+++I E++   L  ++    +D  +    L+S+ FQ+LQA  FCH RRV+HRD+K QN+LV+++  I KL DFGL+R IG      T  VVTL+YR+PE+++    Y  GVD+WS+GC+F EM  K P F+ D EI   F  F  LG P +      + +P  K  F        ++ F   K  K  ++   F L+  + IY+P  R+ A  AL+H YF + D S  PA
Sbjct:    8 EVAHEGDSVYTLNDFTKLEKIGEGTYGVVYKGKNRRTNAMVAMKKIRLESEDEGVPSTAVREISLLKELQHPNVVGLEAVIMQENRLFLIFEFLSFDLKRYMDQLGKDEYLPLETLKSYTFQILQAMCFCHQRRVIHRDLKPQNLLVDNNGAI-KLADFGLARAIGIPIRVYTHEVVTLWYRAPEILMGAQRYSMGVDMWSIGCIFAEMATKKPLFQGDSEIDELFRIFRVLGTPTELEWNGVESLPDYKATFPKWRENFLRDKFYDKKTGKHLLDDTAFSLLEGLLIYDPSLRLNAKKALVHPYFDNMDTSKLPA 322          
BLAST of Cyclin-dependent kinase vs. Ensembl Celegans
Match: cdk-2 (Cyclin-dependent kinase 2 [Source:UniProtKB/Swiss-Prot;Acc:O61847])

HSP 1 Score: 186.808 bits (473), Expect = 1.386e-55
Identity = 110/302 (36.42%), Postives = 170/302 (56.29%), Query Frame = 1
Query:   88 LFTDIPHQLYRIGDYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSSNLL-----QSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTK-VNSKCFDLIMQMFIYNPLKRIGASAALLHEYF 960
            + TDI  +    G +  L ++G  +YG V+ A + ++    ALK ++ D   EGIP+T LREIS +K LQH NI+ L  ++ ++ ++YM+ E++   L   L   + ++++L     +SFM+QLL A ++CH RR++HRD+K QNILV+ S  ++K+ DFGL+R   F     T  VVTL+YR PE++L    Y + +D+WSLGC+F E+    P F  + EI   F  F  +G PN    PG    F        +   N  KL +T  +     D++ ++  Y P +R+ A  AL H YF
Sbjct:    1 MTTDIAPERDLQGRFCSLRRIGEGTYGVVFKAIHVRDNVKCALKMIRTDRDEEGIPSTCLREISCIKDLQHDNIVTLFDIIYANSKLYMVFEFIDRDLKNLLEMLEPTNSVLPPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNILVSDS-GVIKIADFGLARNFSFPSRNYTHEVVTLWYRPPEILLGSQRYSTSLDMWSLGCIFSEIASNKPLFPGECEISQLFKIFEIVGTPNIKSWPGVD-SFPHYKAVFPQWPVNLKKLEETSCLTGNGLDVLREILRYPPERRLTAKGALSHRYF 300          
BLAST of Cyclin-dependent kinase vs. Ensembl Celegans
Match: cdk-5 (Cyclin-dependent-like kinase 5 [Source:UniProtKB/Swiss-Prot;Acc:G5ECH7])

HSP 1 Score: 177.178 bits (448), Expect = 1.939e-52
Identity = 96/281 (34.16%), Postives = 161/281 (57.30%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD--VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPF----RVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHD 966
            G+YG V+ A+NK +  + ALK++++D   EG+P++ LREI +L+ L+H N++ L+ V+ S+ ++ ++ EY    L  F    +  + +   +S M QLL+  +FCH   VLHRD+K QN+L+N +   +KL DFGL+R  G      +  VVTL+YR P+++    +Y + +D+WS GC+F E+     P      VD +++  F    QLG P++D+ P      +   +     +    +++   +NS+  DL+ ++ + NP  RI A AAL H YF D
Sbjct:   13 GTYGTVFKARNKNSGEIVALKRVRLDDDDEGVPSSALREICILRELKHRNVVRLYDVVHSENKLTLVFEYCDQDLKKFFDSLNGYMDAQTARSLMLQLLRGLSFCHAHHVLHRDLKPQNLLIN-TNGTLKLADFGLARAFGVPVRCFSAEVVTLWYRPPDVLFGAKLYNTSIDMWSAGCIFAEISNAGRPLFPGADVDDQLKRIFK---QLGSPSEDNWPSITQLPDYKPYPIYHPTLTWSQIVPN-LNSRGRDLLQKLLVCNPAGRIDADAALRHAYFAD 288          
BLAST of Cyclin-dependent kinase vs. Ensembl Celegans
Match: cdk-11.2 (Cyclin-Dependent Kinase family [Source:UniProtKB/TrEMBL;Acc:Q23357])

HSP 1 Score: 183.726 bits (465), Expect = 1.221e-51
Identity = 117/332 (35.24%), Postives = 175/332 (52.71%), Query Frame = 1
Query:  121 IGDYAILSKL--GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREIS-LLKILQHPNIINLHQVLVSDKR--IYMIMEYMKMSLNLFL-----RDFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPG-----RLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAK-------VKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVA-------PAIGEENVGFPE 1020
            I +Y IL+ +  G+YG V+  KN +   + ALK+ K++   EG P T LREI+ LLK   H NI+N+ ++LV   +  +YM MEY++  +   +     R+    +   ++ M QLL      H   +LHRD+K+ N+L++HS  I+K+ DFGL+R+ G         +LTP VVTL+YRSPEL+L    Y + VD+WS+GC+  E ++  P F+ D E       F  +G P +   P  K       V+F  +   + +  F   KL    VN   FDL+  M   NP  R+ AS AL H++F +  ++V        PA  E N   PE
Sbjct:  301 ISEYVILNVIAEGTYGEVFRGKNTRTDEVVALKRFKMEKEKEGFPITALREINMLLKAGAHENIVNVKEILVGSTKTEVYMAMEYVEHDVKSLIDKMRSRNQRFKTGQQKTLMSQLLSGIEHMHKLWILHRDLKTSNLLISHS-GILKIADFGLAREYGEARDIEKRMKLTPIVVTLWYRSPELLLEPKTYSTPVDMWSIGCIMAEFIMMKPMFQGDSEPNQVHQIFQMMGTPTEQIWPDIKELKVWNMVEFPPVKPGQLRRIFKGEKL----VNETGFDLLNGMLCLNPANRLTASEALQHDWFSEHPKAVPPEDLPVYPAKSELNAAPPE 627          
BLAST of Cyclin-dependent kinase vs. Ensembl Fly
Match: Cdk1 (gene:FBgn0004106 transcript:FBtr0080051)

HSP 1 Score: 213.386 bits (542), Expect = 3.003e-66
Identity = 114/285 (40.00%), Postives = 168/285 (58.95%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKI---DEGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDV----SSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSF-----NAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDF 969
            G+YG VY  +N+    + A+KK+++   DEG+P+T +REISLLK L+H NI+ L  VL+ + RIY+I E++ M L  ++    V     S L++S+++Q+  A  FCH RRVLHRD+K QN+L++ S  ++K+ DFGL R  G      T  +VTL+YR+PE++L    Y   VDIWS+GC+F EM  + P F+ D EI   F  F  L  P +D  PG        +  + KN+F     N +      +++   DLI +M IY+P+ RI A   L H YF+ F
Sbjct:   13 GTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVCLEDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLKPQNLLIDKS-GLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGV------TSLPDYKNTFPCWSTNQLTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYFNGF 290          
BLAST of Cyclin-dependent kinase vs. Ensembl Fly
Match: Cdk2 (gene:FBgn0004107 transcript:FBtr0083922)

HSP 1 Score: 202.601 bits (514), Expect = 5.905e-62
Identity = 114/299 (38.13%), Postives = 169/299 (56.52%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDV--SSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINA 1032
            G+YG VY A++       ALKK++++   EG+P+T +REISLLK L+HPN++ L  V++S   +YMI EY+ M L   +       +  L++S+M Q+L A  FCH  R+LHRD+K QN+LV+ + KI KL DFGL+R         T  VVTL+YR+PE++L    Y +GVDIWSLGC+F EM+++   F  D EI   +  F  L  P++ + PG     +  +F+     +    + +     +  +LIM M  Y+P  RI A  AL H YF +           ++V  P + NA
Sbjct:   17 GTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQLFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQNLLVDTAGKI-KLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVT---QLPDFKTKFPRWEGTNMPQPITEHEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQHV-------DHVALPVDPNA 304          
BLAST of Cyclin-dependent kinase vs. Ensembl Fly
Match: Cdk2 (gene:FBgn0004107 transcript:FBtr0300447)

HSP 1 Score: 202.601 bits (514), Expect = 5.905e-62
Identity = 114/299 (38.13%), Postives = 169/299 (56.52%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDV--SSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINA 1032
            G+YG VY A++       ALKK++++   EG+P+T +REISLLK L+HPN++ L  V++S   +YMI EY+ M L   +       +  L++S+M Q+L A  FCH  R+LHRD+K QN+LV+ + KI KL DFGL+R         T  VVTL+YR+PE++L    Y +GVDIWSLGC+F EM+++   F  D EI   +  F  L  P++ + PG     +  +F+     +    + +     +  +LIM M  Y+P  RI A  AL H YF +           ++V  P + NA
Sbjct:   17 GTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQLFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQNLLVDTAGKI-KLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVT---QLPDFKTKFPRWEGTNMPQPITEHEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQHV-------DHVALPVDPNA 304          
BLAST of Cyclin-dependent kinase vs. Ensembl Fly
Match: Cdk2 (gene:FBgn0004107 transcript:FBtr0083921)

HSP 1 Score: 202.601 bits (514), Expect = 5.905e-62
Identity = 114/299 (38.13%), Postives = 169/299 (56.52%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDV--SSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINA 1032
            G+YG VY A++       ALKK++++   EG+P+T +REISLLK L+HPN++ L  V++S   +YMI EY+ M L   +       +  L++S+M Q+L A  FCH  R+LHRD+K QN+LV+ + KI KL DFGL+R         T  VVTL+YR+PE++L    Y +GVDIWSLGC+F EM+++   F  D EI   +  F  L  P++ + PG     +  +F+     +    + +     +  +LIM M  Y+P  RI A  AL H YF +           ++V  P + NA
Sbjct:   17 GTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQLFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQNLLVDTAGKI-KLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVT---QLPDFKTKFPRWEGTNMPQPITEHEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQHV-------DHVALPVDPNA 304          
BLAST of Cyclin-dependent kinase vs. Ensembl Fly
Match: Cdk5 (gene:FBgn0013762 transcript:FBtr0087350)

HSP 1 Score: 185.267 bits (469), Expect = 1.832e-55
Identity = 105/285 (36.84%), Postives = 161/285 (56.49%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKIDE---GIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDF--DVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMV-LKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAI---KLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRS 978
            G+YG V+  +N+    + ALK++++DE   G+P++ LREI LLK L+H NI+ L  VL SDK++ ++ E+    L  +      ++   + +SFM QLL+  AFCH+  VLHRD+K QN+L+N + ++ KL DFGL+R  G      +  VVTL+YR P+++    +Y + +D+WS GC+  E+     P F     +      F  LG PN+D  PG       ++   +  SF AI     L  ++NSK  DL+ ++ I  P +RI A AA+ H YF D   S
Sbjct:   13 GTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLIDVLHSDKKLTLVFEHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGEL-KLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGV----SHLSDYVALPSFPAITSWSQLVPRLNSKGRDLLQKLLICRPNQRISAEAAMQHPYFTDSSSS 292          
BLAST of Cyclin-dependent kinase vs. Ensembl Zebrafish
Match: cdk1 (cyclin-dependent kinase 1 [Source:ZFIN;Acc:ZDB-GENE-010320-1])

HSP 1 Score: 224.172 bits (570), Expect = 2.791e-70
Identity = 118/299 (39.46%), Postives = 180/299 (60.20%), Query Frame = 1
Query:  121 IGDYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPA 990
            + DY  + K+G  +YG VY  +NK    + A+KK++++   EG+P+T +REISLLK LQHPN++ L  VL+ + ++Y++ E++ M L  +L        +   L++S+++Q+L+   FCH RRVLHRD+K QN+L+++   ++KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VD+WS+G +F E+  K P F  D EI   F  F  LG PN++  P  +   +  N      S N    +K  ++    DL+M+M IY+P KRI A  A+ H YF D D+S  PA
Sbjct:    1 MDDYLKIEKIGEGTYGVVYKGRNKTTGQVVAMKKIRLESEEEGVPSTAVREISLLKELQHPNVVRLLDVLMQESKLYLVFEFLSMDLKKYLDSIPSGEFMDPMLVKSYLYQILEGILFCHCRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGASRYSTPVDLWSIGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPNNEVWPDVESLPDYKNTFPKWKSGNLANTVKN-LDKNGIDLLMKMLIYDPPKRISARQAMTHPYFDDLDKSSLPA 297          
BLAST of Cyclin-dependent kinase vs. Ensembl Zebrafish
Match: cdk1 (cyclin-dependent kinase 1 [Source:ZFIN;Acc:ZDB-GENE-010320-1])

HSP 1 Score: 224.172 bits (570), Expect = 2.791e-70
Identity = 118/299 (39.46%), Postives = 180/299 (60.20%), Query Frame = 1
Query:  121 IGDYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPA 990
            + DY  + K+G  +YG VY  +NK    + A+KK++++   EG+P+T +REISLLK LQHPN++ L  VL+ + ++Y++ E++ M L  +L        +   L++S+++Q+L+   FCH RRVLHRD+K QN+L+++   ++KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VD+WS+G +F E+  K P F  D EI   F  F  LG PN++  P  +   +  N      S N    +K  ++    DL+M+M IY+P KRI A  A+ H YF D D+S  PA
Sbjct:    1 MDDYLKIEKIGEGTYGVVYKGRNKTTGQVVAMKKIRLESEEEGVPSTAVREISLLKELQHPNVVRLLDVLMQESKLYLVFEFLSMDLKKYLDSIPSGEFMDPMLVKSYLYQILEGILFCHCRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGASRYSTPVDLWSIGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPNNEVWPDVESLPDYKNTFPKWKSGNLANTVKN-LDKNGIDLLMKMLIYDPPKRISARQAMTHPYFDDLDKSSLPA 297          
BLAST of Cyclin-dependent kinase vs. Ensembl Zebrafish
Match: cdk2 (cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2741])

HSP 1 Score: 222.246 bits (565), Expect = 1.368e-69
Identity = 124/288 (43.06%), Postives = 172/288 (59.72%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSS---NLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESM-NFQESKNSFNAIKLLKT--KVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAP 987
            G+YG VY AKNK      ALKK+++D   EG+P+T +REISLLK L HPNI+ L  V+ ++ ++Y++ E++   L  F+    VS     L++S++FQLLQ  AFCH+ RVLHRD+K QN+L+N   +I KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VDIWSLGC+F EM+ +   F  D EI   F  F  LG P++   PG      SM +++ S   +    L K    ++    DL+ QM  Y+P KRI A  AL+H +F D    V P
Sbjct:   13 GTYGVVYKAKNKVTGETVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLRDVIHTENKLYLVFEFLHQDLKRFMDSTSVSGISLPLVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAQGEI-KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPDESIWPGVT----SMPDYKPSFPKWARQDLSKVVPPLDEDGRDLLGQMLTYDPNKRISAKNALVHRFFRDVTMPVPP 295          
BLAST of Cyclin-dependent kinase vs. Ensembl Zebrafish
Match: cdk5 (cyclin-dependent kinase 5 [Source:ZFIN;Acc:ZDB-GENE-010131-2])

HSP 1 Score: 190.66 bits (483), Expect = 2.220e-57
Identity = 109/301 (36.21%), Postives = 174/301 (57.81%), Query Frame = 1
Query:  130 YAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLR--DFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPF----RVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMN----------FQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDF 969
            Y  L K+G  +YG V+ AKN++   + ALK++++D   EG+P++ LREI LLK L+H NI+ LH VL SDK++ ++ EY    L  +    + D+   +++SFM+QLL+  AFCH+R VLHRD+K QN+L+N + ++ KL DFGL+R  G      +  VVTL+YR P+++    +Y + +D+WS GC+F E+     P      VD +++  F     LG P ++       ++++MN          +  + +  N +     K++S   DL+  +   NP++RI A  AL H YF DF
Sbjct:    4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEYCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGEL-KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRL---LGTPTEE-------QWQTMNKLPDYKPYPMYPATTSLVNVV----PKLSSTGRDLLQNLLKCNPVQRISAEEALQHPYFADF 289          
BLAST of Cyclin-dependent kinase vs. Ensembl Zebrafish
Match: cdk4 (cyclin-dependent kinase 4 [Source:ZFIN;Acc:ZDB-GENE-060929-974])

HSP 1 Score: 175.637 bits (444), Expect = 1.369e-51
Identity = 108/286 (37.76%), Postives = 158/286 (55.24%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQ---HPNIINLHQVLVS-----DKRIYMIMEYMKMSLNLFLRDFDVSS---NLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHD 966
            G+YG VY A+++ +    ALK +++    +G+P +T+RE++LLK L+   HPNI+ L  V  +     + ++ ++ E++   L  +L          + ++  M QLL   AF H  RVLHRD+K +NILV  S   VKL DFGL+R I  C   LTP VVTL+YRSPE++L +  Y + VDIWS GC+F EM  + P F  D E       F  +G+P +D  P   V     NF  S  S   I      +  K  +L+++M  ++PLKRI A  AL H +F +
Sbjct:   18 GAYGTVYKARDRDSGQFVALKSVRVQTNQDGLPLSTVREVALLKRLEQFDHPNIVRLMDVCATLRTDQETKVTLVFEHVDQDLRTYLEKVPAPGLPVDKIRDLMQQLLCGLAFLHTNRVLHRDLKPENILVT-SRGQVKLADFGLAR-IYSCHMALTPVVVTLWYRSPEVLL-QSTYATPVDIWSTGCIFAEMFRRKPLFCGDSEADQLGKIFAVIGLPAEDQWP-TDVTLSHHNF--SPQSPRPITDCVPDITEKGAELLLKMLTFDPLKRISALNALDHPFFSE 297          
BLAST of Cyclin-dependent kinase vs. Ensembl Xenopus
Match: cfap65 (cilia and flagella associated protein 65 [Source:Xenbase;Acc:XB-GENE-1001102])

HSP 1 Score: 234.572 bits (597), Expect = 3.695e-74
Identity = 125/292 (42.81%), Postives = 178/292 (60.96%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSK-----CFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPA 990
            G+YG VY  ++K    + A+KK++++   EG+P+T +REISLLK LQHPNI+ L  VL+ D R+Y+I E++ M L  +L        + + L++S+++Q+LQ   FCH+RRVLHRD+K QN+L++ S  ++KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VD+WS+G +F E+  K P F  D EI   F  F  LG PN++  P      E  + Q+ KN+F   K      N K       DL+ +M IY+P KRI A  ALLH YF D D+S  PA
Sbjct:   13 GTYGVVYKGRHKATGQVVAMKKIRLENEEEGVPSTAIREISLLKELQHPNIVCLLDVLMQDSRLYLIFEFLSMDLKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-SKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSVRYSTPVDVWSIGTIFAEIATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP------EVESLQDYKNTFPKWKGGNLSANVKNIDKDGLDLLSKMLIYDPAKRISARKALLHPYFDDLDKSSLPA 297          
BLAST of Cyclin-dependent kinase vs. Ensembl Xenopus
Match: cfap65 (cilia and flagella associated protein 65 [Source:Xenbase;Acc:XB-GENE-1001102])

HSP 1 Score: 231.876 bits (590), Expect = 3.834e-73
Identity = 124/292 (42.47%), Postives = 177/292 (60.62%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSK-----CFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPA 990
             +YG VY  ++K    + A+KK++++   EG+P+T +REISLLK LQHPNI+ L  VL+ D R+Y+I E++ M L  +L        + + L++S+++Q+LQ   FCH+RRVLHRD+K QN+L++ S  ++KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VD+WS+G +F E+  K P F  D EI   F  F  LG PN++  P      E  + Q+ KN+F   K      N K       DL+ +M IY+P KRI A  ALLH YF D D+S  PA
Sbjct:    6 STYGVVYKGRHKATGQVVAMKKIRLENEEEGVPSTAIREISLLKELQHPNIVCLLDVLMQDSRLYLIFEFLSMDLKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-SKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSVRYSTPVDVWSIGTIFAEIATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP------EVESLQDYKNTFPKWKGGNLSANVKNIDKDGLDLLSKMLIYDPAKRISARKALLHPYFDDLDKSSLPA 290          
BLAST of Cyclin-dependent kinase vs. Ensembl Xenopus
Match: cfap65 (cilia and flagella associated protein 65 [Source:Xenbase;Acc:XB-GENE-1001102])

HSP 1 Score: 231.491 bits (589), Expect = 5.790e-73
Identity = 124/291 (42.61%), Postives = 177/291 (60.82%), Query Frame = 1
Query:  154 SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSK-----CFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPA 990
            +YG VY  ++K    + A+KK++++   EG+P+T +REISLLK LQHPNI+ L  VL+ D R+Y+I E++ M L  +L        + + L++S+++Q+LQ   FCH+RRVLHRD+K QN+L++ S  ++KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VD+WS+G +F E+  K P F  D EI   F  F  LG PN++  P      E  + Q+ KN+F   K      N K       DL+ +M IY+P KRI A  ALLH YF D D+S  PA
Sbjct:   12 TYGVVYKGRHKATGQVVAMKKIRLENEEEGVPSTAIREISLLKELQHPNIVCLLDVLMQDSRLYLIFEFLSMDLKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-SKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSVRYSTPVDVWSIGTIFAEIATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP------EVESLQDYKNTFPKWKGGNLSANVKNIDKDGLDLLSKMLIYDPAKRISARKALLHPYFDDLDKSSLPA 295          
BLAST of Cyclin-dependent kinase vs. Ensembl Xenopus
Match: cdk2 (cyclin-dependent kinase 2 [Source:NCBI gene;Acc:493498])

HSP 1 Score: 221.09 bits (562), Expect = 5.428e-69
Identity = 117/283 (41.34%), Postives = 172/283 (60.78%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSS---NLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKV--KFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDR 975
            G+YG VY A+N++   + ALKK+++D   EG+P+T +REISLLK L HPNI+ L  V+ ++ ++Y++ E++   L  F+   ++S     L++S++FQLLQ  AFCH+ RVLHRD+K QN+L+N S   +KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VDIWSLGC+F EM+ +   F  D EI   F  F  LG P++   PG      ++S   +  +  F+ +      ++    DL+ QM  Y+  KRI A AAL H +F D  R
Sbjct:   13 GTYGVVYKARNRETGEIVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLNQDLKKFMDGSNISGISLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-SEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKFYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPDEVSWPGVTTMPDYKSTFPKWVRQDFSKV---VPPLDDDGRDLLAQMLQYDSNKRISAKAALTHAFFRDVSR 291          
BLAST of Cyclin-dependent kinase vs. Ensembl Xenopus
Match: cdk2 (cyclin-dependent kinase 2 [Source:NCBI gene;Acc:493498])

HSP 1 Score: 206.838 bits (525), Expect = 3.911e-63
Identity = 117/307 (38.11%), Postives = 172/307 (56.03%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSS---NLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEM------------------------VLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKV--KFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDR 975
            G+YG VY A+N++   + ALKK+++D   EG+P+T +REISLLK L HPNI+ L  V+ ++ ++Y++ E++   L  F+   ++S     L++S++FQLLQ  AFCH+ RVLHRD+K QN+L+N S   +KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VDIWSLGC+F EM                        + +   F  D EI   F  F  LG P++   PG      ++S   +  +  F+ +      ++    DL+ QM  Y+  KRI A AAL H +F D  R
Sbjct:   13 GTYGVVYKARNRETGEIVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLNQDLKKFMDGSNISGISLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-SEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKFYSTAVDIWSLGCIFAEMQECRPNIAEFCRQDENNGCNVFHTITRRALFPGDSEIDQLFRIFRTLGTPDEVSWPGVTTMPDYKSTFPKWVRQDFSKV---VPPLDDDGRDLLAQMLQYDSNKRISAKAALTHAFFRDVSR 315          
BLAST of Cyclin-dependent kinase vs. Ensembl Mouse
Match: Cdk1 (cyclin-dependent kinase 1 [Source:MGI Symbol;Acc:MGI:88351])

HSP 1 Score: 224.172 bits (570), Expect = 2.203e-70
Identity = 123/299 (41.14%), Postives = 179/299 (59.87%), Query Frame = 1
Query:  127 DYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIK--LLKTKV---NSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSV 981
            DY  + K+G  +YG VY  +++    + A+KK++++   EG+P+T +REISLLK L+HPNI++L  VL+ D R+Y+I E++ M L  +L        + S+L++S++ Q+LQ   FCH+RRVLHRD+K QN+L++    I KL DFGL+R  G      T  VVTL+YRSPE++L    Y + VDIWS+G +F E+  K P F  D EI   F  F  LG PN++  P      E  + Q+ KN+F   K   L + V   +    DL+ +M +Y+P KRI    AL H YF D D  +
Sbjct:    3 DYIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI-KLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP------EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLVYDPAKRISGKMALKHPYFDDLDNQI 294          
BLAST of Cyclin-dependent kinase vs. Ensembl Mouse
Match: Cdk1 (cyclin-dependent kinase 1 [Source:MGI Symbol;Acc:MGI:88351])

HSP 1 Score: 224.172 bits (570), Expect = 2.203e-70
Identity = 123/299 (41.14%), Postives = 179/299 (59.87%), Query Frame = 1
Query:  127 DYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIK--LLKTKV---NSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSV 981
            DY  + K+G  +YG VY  +++    + A+KK++++   EG+P+T +REISLLK L+HPNI++L  VL+ D R+Y+I E++ M L  +L        + S+L++S++ Q+LQ   FCH+RRVLHRD+K QN+L++    I KL DFGL+R  G      T  VVTL+YRSPE++L    Y + VDIWS+G +F E+  K P F  D EI   F  F  LG PN++  P      E  + Q+ KN+F   K   L + V   +    DL+ +M +Y+P KRI    AL H YF D D  +
Sbjct:    3 DYIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI-KLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP------EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLVYDPAKRISGKMALKHPYFDDLDNQI 294          
BLAST of Cyclin-dependent kinase vs. Ensembl Mouse
Match: Cdk2 (cyclin-dependent kinase 2 [Source:MGI Symbol;Acc:MGI:104772])

HSP 1 Score: 214.157 bits (544), Expect = 2.278e-66
Identity = 118/285 (41.40%), Postives = 170/285 (59.65%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSS---NLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKV--KFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSV 981
            G+YG VY AKNK    + ALKK+++D   EG+P+T +REISLLK L HPNI+ L  V+ ++ ++Y++ E++   L  F+    ++     L++S++FQLLQ  AFCH+ RVLHRD+K QN+L+N    I KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VDIWSLGC+F EMV +   F  D EI   F  F  LG P++   PG      ++    + ++  F+ +      ++     L+ QM  Y+P KRI A AAL H +F D  + V
Sbjct:   13 GTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSI-KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKV---VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293          
BLAST of Cyclin-dependent kinase vs. Ensembl Mouse
Match: Cdk3 (cyclin-dependent kinase 3 [Source:MGI Symbol;Acc:MGI:1916931])

HSP 1 Score: 204.912 bits (520), Expect = 1.039e-62
Identity = 119/306 (38.89%), Postives = 181/306 (59.15%), Query Frame = 1
Query:   97 DIPHQLYRIGDYAILSKLGSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSSNL----LQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQES--KNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAP 987
            D+  ++ +IG+       G+YG VY A+NK    L ALKK+++D   EG+P+T +REISLLK L+HPNII L  V+  +K++YM+ E++   L   + D   +S L    ++S++ QLL+  +FCH+ RV+HRD+K QN+L++  +  +KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VDI S+GC+F EMV     F  D EI   F  F  LG P++   PG     +  ++Q S  K S   ++ +   +  +  DL++++  Y+P +RI A  AL H YF     S+AP
Sbjct:    2 DVFQKVEKIGE-------GTYGVVYKARNKVTGQLVALKKIRLDLEAEGVPSTAVREISLLKELKHPNIIKLLDVVHREKKLYMVFEFLTQDLKRHM-DSSPTSELPLPVVKSYLAQLLEGVSFCHSHRVIHRDLKPQNLLLD-GLGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYSTAVDI*SIGCIFAEMVTGKALFPGDSEIDQLFRIFRTLGTPSEATWPGVS---QMPDYQSSFPKWSRKGLEEIVPSLGPEGKDLLLRLLQYDPSQRISAKTALAHPYFSP-GHSLAP 294          
BLAST of Cyclin-dependent kinase vs. Ensembl Mouse
Match: Cdk5 (cyclin-dependent kinase 5 [Source:MGI Symbol;Acc:MGI:101765])

HSP 1 Score: 192.2 bits (487), Expect = 5.976e-58
Identity = 107/291 (36.77%), Postives = 169/291 (58.08%), Query Frame = 1
Query:  130 YAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLR--DFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPF----RVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDF 969
            Y  L K+G  +YG V+ AKN++   + ALK++++D   EG+P++ LREI LLK L+H NI+ LH VL SDK++ ++ E+    L  +    + D+   +++SF+FQLL+   FCH+R VLHRD+K QN+L+N + ++ KL DFGL+R  G      +  VVTL+YR P+++    +Y + +D+WS GC+F E+     P      VD +++  F     LG P ++  P A  K           +  ++  +  K+N+   DL+  +   NP++RI A  AL H YF DF
Sbjct:    4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGEL-KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRL---LGTPTEEQWP-AMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289          
BLAST of Cyclin-dependent kinase vs. UniProt/SwissProt
Match: sp|P35567|CDK1A_XENLA (Cyclin-dependent kinase 1-A OS=Xenopus laevis OX=8355 GN=cdk1-a PE=1 SV=1)

HSP 1 Score: 234.187 bits (596), Expect = 2.647e-73
Identity = 125/291 (42.96%), Postives = 177/291 (60.82%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSK-----CFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAP 987
            G+YG VY  ++K    + A+KK++++   EG+P+T +REISLLK LQHPNI+ L  VL+ D R+Y+I E++ M L  +L        + + L++S+++Q+LQ   FCH+RRVLHRD+K QN+L++ S  ++KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VD+WS+G +F E+  K P F  D EI   F  F  LG PN++  P      E  + Q+ KNSF   K      N K       DL+ +M IY+P KRI A  ALLH YF D D+S  P
Sbjct:   13 GTYGVVYKGRHKATGQVVAMKKIRLENEEEGVPSTAIREISLLKELQHPNIVCLLDVLMQDSRLYLIFEFLSMDLKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-SKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSVRYSTPVDVWSIGTIFAEIATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP------EVESLQDYKNSFPKWKGGSLSANVKNIDKDGLDLLAKMLIYDPAKRISARKALLHPYFDDLDKSSLP 296          
BLAST of Cyclin-dependent kinase vs. UniProt/SwissProt
Match: sp|P13863|CDK1_CHICK (Cyclin-dependent kinase 1 OS=Gallus gallus OX=9031 GN=CDK1 PE=1 SV=1)

HSP 1 Score: 233.032 bits (593), Expect = 8.838e-73
Identity = 127/302 (42.05%), Postives = 180/302 (59.60%), Query Frame = 1
Query:  127 DYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSSNL----LQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIK--LLKTKV---NSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPA 990
            DY  + K+G  +YG VY  ++K    + A+KK++++   EG+P+T +REISLLK L HPNI+ L  VL+ D R+Y+I E++ M L  +L        L    ++S+++Q+LQ   FCH+RRVLHRD+K QN+L++    ++KL DFGL+R  G      T  VVTL+YRSPE++L   +Y + VDIWS+G +F E+  K P F  D EI   F  F  LG PN+D  P  +      + Q+ KN+F   K   L T V   +    DL+ +M IY+P KRI    AL H YF D D+S  PA
Sbjct:    3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELHHPNIVCLQDVLMQDARLYLIFEFLSMDLKKYLDTIPSGQYLDRSRVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDK-GVIKLADFGLARAFGIPVRVYTHEVVTLWYRSPEVLLGSALYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNDVWPDVE------SLQDYKNTFPKWKPGSLGTHVQNLDEDGLDLLSKMLIYDPAKRISGKMALNHPYFDDLDKSTLPA 297          
BLAST of Cyclin-dependent kinase vs. UniProt/SwissProt
Match: sp|P06493|CDK1_HUMAN (Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 GN=CDK1 PE=1 SV=3)

HSP 1 Score: 228.794 bits (582), Expect = 3.228e-71
Identity = 125/299 (41.81%), Postives = 181/299 (60.54%), Query Frame = 1
Query:  127 DYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIK--LLKTKV---NSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSV 981
            DY  + K+G  +YG VY  ++K    + A+KK++++   EG+P+T +REISLLK L+HPNI++L  VL+ D R+Y+I E++ M L  +L        + S+L++S+++Q+LQ   FCH+RRVLHRD+K QN+L++    I KL DFGL+R  G      T  VVTL+YRSPE++L    Y + VDIWS+G +F E+  K P F  D EI   F  F  LG PN++  P      E  + Q+ KN+F   K   L + V   +    DL+ +M IY+P KRI    AL H YF+D D  +
Sbjct:    3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI-KLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP------EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294          
BLAST of Cyclin-dependent kinase vs. UniProt/SwissProt
Match: sp|P24033|CDK1B_XENLA (Cyclin-dependent kinase 1-B OS=Xenopus laevis OX=8355 GN=cdk1-b PE=1 SV=2)

HSP 1 Score: 228.409 bits (581), Expect = 4.467e-71
Identity = 123/302 (40.73%), Postives = 182/302 (60.26%), Query Frame = 1
Query:  127 DYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSK-----CFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPA 990
            +Y  + K+G  +YG VY  ++K    + A+KK++++   EG+P+T +REISLLK LQHPNI+ L  VL+ D R+Y+I E++ M L  +L        + + L++S+++Q+LQ   FCH+RRVLHRD+K QN+L+++   ++KL DFGL+R  G      T  VVTL+YR+ E++L    Y + VD+WS+G +F E+  K P F  D EI   F  F  LG PN++  P      E  + Q+ KN+F   K      N K       DL+ +M +Y+P KRI A  A+LH YF D D+S  PA
Sbjct:    3 EYTKIEKIGEGTYGVVYKGRHKATGQVVAMKKIRLENEEEGVPSTAIREISLLKELQHPNIVCLLDVLMQDSRLYLIFEFLSMDLKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGIPVRVYTHEVVTLWYRASEVLLGSVRYSTPVDVWSVGTIFAEIATKKPLFHGDSEIDQLFRIFRSLGTPNNEVWP------EVESLQDYKNTFPKWKGGSLSSNVKNIDEDGLDLLSKMLVYDPAKRISARKAMLHPYFDDLDKSSLPA 297          
BLAST of Cyclin-dependent kinase vs. UniProt/SwissProt
Match: sp|A8XA58|CDK1_CAEBR (Cyclin-dependent kinase 1 OS=Caenorhabditis briggsae OX=6238 GN=cdk-1 PE=3 SV=1)

HSP 1 Score: 229.18 bits (583), Expect = 4.571e-71
Identity = 122/307 (39.74%), Postives = 181/307 (58.96%), Query Frame = 1
Query:  115 YRIGDYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKI---DEGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFL----RDFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPND------DDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPA 990
            Y + D+  L K+G  +YG VY  +N++ + + A+KK+++   DEG+P+T +REISLLK LQHPN++ L  V++ + R+Y+I E++   L  ++    ++  + S  L+S+ FQ+LQA  FCH RRV+HRD+K QN+LV+    I KL DFGL+R IG      T  VVTL+YR+PE+++    Y  GVD+WS+GC+F EM  K P F+ D EI   F  F  LG P +      + +P  K  F        ++ F   K     ++   F L+  + IY+P  RI +  AL H YF+D D S  PA
Sbjct:   11 YTLDDFTKLEKIGEGTYGVVYKGRNRRTQAMVAMKKIRLESEDEGVPSTAVREISLLKELQHPNVVGLEAVIMQENRLYLIFEFLSYDLKRYMDTLSKEEYLPSETLKSYTFQILQAMCFCHQRRVIHRDLKPQNLLVDEKGAI-KLADFGLARAIGIPIRVYTHEVVTLWYRAPEILMGAQRYSMGVDMWSIGCIFAEMATKKPLFQGDSEIDELFRIFRILGTPTELEWNGVESLPDYKATFPKWRENFLRDKFYDKKSGNYLMDEDAFSLLEGLLIYDPALRISSKKALHHPYFNDIDTSKLPA 316          
BLAST of Cyclin-dependent kinase vs. TrEMBL
Match: Q5DB60 (Cyclin-dependent kinase 1 isoform 2 OS=Schistosoma japonicum OX=6182 GN=EWB00_003272 PE=2 SV=1)

HSP 1 Score: 268.855 bits (686), Expect = 6.610e-83
Identity = 152/360 (42.22%), Postives = 212/360 (58.89%), Query Frame = 1
Query:  115 YRIGDYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSS----NLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKV--KFESMNFQESKNSFNAIKLLKTKV-NSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINAPRKPQVLYLTTDHLEGLNDQGNMETK*NLYFCFQKQQRHLIN 1158
            Y + D+  L K+G  +YG VY  KNK N    ALKK++++   EG+P+T +REISLLK LQHPNI+NL QV++ + R+Y++ EY+ + L  +L D    S     +++SFM+Q+LQ   FCH RRV+HRD+K QNILV+   KIVKL DFGL+R  G     LT  VVTL+YR+PE++L    Y   VDIWS+GC+F E+  K   FR D EI   F  F  LG P+++  PG     +++  +F   +NS  +I+    K  N    DL+  M IY P +RI A  ALLH YF D D+++ PA GEE +G P +   PR+   ++L  D  E  ++  + E    L    Q     L N
Sbjct:    7 YALSDFMRLEKIGEGTYGVVYKCKNKVNSKFAALKKIRLENDEEGVPSTAIREISLLKELQHPNIVNLEQVIMENGRLYLVFEYLNVDLKRYLDDSGRKSLLEPGIVKSFMYQMLQGLLFCHGRRVIHRDLKPQNILVDIGRKIVKLADFGLARAFGIPVRVLTHEVVTLWYRAPEILLGAQRYSCAVDIWSMGCIFSEVATKEALFRGDSEIDQLFRIFRLLGTPSEEVWPGVSSLPEYQKKSFPIWRNSKLSIQDNIAKAFNDPGLDLLQAMLIYEPSRRITARDALLHPYFSDLDKALVPATGEEYIGLPLD-QLPREVAAMFL-ADGGEVYHNSNDTENTGKLCLTVQPDTIQLGN 364          
BLAST of Cyclin-dependent kinase vs. TrEMBL
Match: A0A095BXJ3 (Cyclin-dependent kinase 1 OS=Schistosoma haematobium OX=6185 GN=MS3_01917 PE=3 SV=1)

HSP 1 Score: 268.085 bits (684), Expect = 1.561e-82
Identity = 145/328 (44.21%), Postives = 202/328 (61.59%), Query Frame = 1
Query:  115 YRIGDYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKV--KFESMNFQESKNSFNAIKLLKTKV-NSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINAPRKPQVLYLT 1062
            Y + D+  L K+G  +YG VY  KNK N    ALKK++++   EG+P+T +REISLLK LQHPNI+NL QV++ + R+Y++ EY+ + L  +L D      +   +++SFM+Q+LQ   FCH RRV+HRD+K QNILV+   KIVKL DFGL+R  G     LT  VVTL+YR+PE++L    Y   VDIWS+GC+F E+  K   FR D EI   F  F  LG P+++  PG     +++  +F   +NS  +I+    K   S   DL+  M IY P +RI A  ALLH YF D D+S+ PA GEE +G P +   PR+   ++L 
Sbjct:    7 YALSDFIRLEKIGEGTYGVVYKCKNKVNGKFAALKKIRLENDEEGVPSTAIREISLLKELQHPNIVNLEQVIMENGRLYLVFEYLNLDLKRYLDDSGRKNLLEPGIVKSFMYQMLQGLLFCHGRRVIHRDLKPQNILVDIGRKIVKLADFGLARAFGIPVRVLTHEVVTLWYRAPEILLGAQRYSCAVDIWSMGCIFSEVSTKEALFRGDSEIDQLFRIFRLLGTPSEEVWPGVSSLPEYQKKSFPVWRNSKLSIQDNIAKAFTSPGLDLLQAMLIYEPSRRITARDALLHPYFSDLDKSLVPATGEEYIGLPLD-QLPREVAAIFLA 333          
BLAST of Cyclin-dependent kinase vs. TrEMBL
Match: G4VLX9 (Serine/threonine kinase OS=Schistosoma mansoni OX=6183 GN=Smp_080730 PE=3 SV=1)

HSP 1 Score: 267.7 bits (683), Expect = 1.957e-82
Identity = 145/328 (44.21%), Postives = 203/328 (61.89%), Query Frame = 1
Query:  115 YRIGDYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKV--KFESMNFQESKNSFNAIKLLKTKV-NSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINAPRKPQVLYLT 1062
            Y + D+  L K+G  +YG VY  KNK N    ALKK++++   EG+P+T +REISLLK LQHPNI+NL QV++ + R+Y++ EY+ + L  +L D      +   +++SFM+Q+LQ   FCH RRV+HRD+K QNILV+   KIVKL DFGL+R  G     LT  VVTL+YR+PE++L    Y   VDIWS+GC+F E+  K   FR D EI   F  F  LG P+++  PG     +++  +F   +NS  +I+    K  +S   DL+  M IY P +RI A  ALLH YF D D+S+ PA GEE +G P +   PR+   ++L 
Sbjct:    7 YALSDFIRLEKIGEGTYGVVYKCKNKVNGKFAALKKIRLENDEEGVPSTAIREISLLKELQHPNIVNLEQVIMENGRLYLVFEYLNLDLKRYLDDSGRKNLLEPGIVKSFMYQMLQGLLFCHGRRVIHRDLKPQNILVDIGRKIVKLADFGLARAFGIPVRVLTHEVVTLWYRAPEILLGAQRYSCAVDIWSMGCIFSEVSTKEALFRGDSEIDQLFRIFRLLGTPSEEVWPGVSSLPEYQKKSFPIWRNSKLSIQDNIAKAFSSPGLDLLQAMLIYEPSRRITARDALLHPYFSDLDKSLVPATGEEYIGLPLD-QLPREVAAIFLA 333          
BLAST of Cyclin-dependent kinase vs. TrEMBL
Match: A0A183LHM5 (Protein kinase domain-containing protein OS=Schistosoma margrebowiei OX=48269 GN=SMRZ_LOCUS3300 PE=3 SV=1)

HSP 1 Score: 267.7 bits (683), Expect = 2.203e-82
Identity = 145/328 (44.21%), Postives = 202/328 (61.59%), Query Frame = 1
Query:  115 YRIGDYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKV--KFESMNFQESKNSFNAIKLLKTKV-NSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINAPRKPQVLYLT 1062
            Y + D+  L K+G  +YG VY  KNK N    ALKK++++   EG+P+T +REISLLK LQHPNI+NL QV++ + R+Y++ EY+ + L  +L D      +   +++SFM+Q+LQ   FCH RRV+HRD+K QNILV+   KIVKL DFGL+R  G     LT  VVTL+YR+PE++L    Y   VDIWS+GC+F E+  K   FR D EI   F  F  LG P+++  PG     +++  +F   +NS  +I+    K   S   DL+  M IY P +RI A  ALLH YF D D+S+ PA GEE +G P +   PR+   ++L 
Sbjct:    7 YALSDFIRLEKIGEGTYGVVYKCKNKVNGKFAALKKIRLENDEEGVPSTAIREISLLKELQHPNIVNLEQVIMENGRLYLVFEYLNVDLKRYLDDSGRKNLLEPGIVKSFMYQMLQGLLFCHGRRVIHRDLKPQNILVDIGRKIVKLADFGLARAFGIPVRVLTHEVVTLWYRAPEILLGAQRYSCAVDIWSMGCIFSEVSTKEALFRGDSEIDQLFRIFRLLGTPSEEVWPGVSSLPEYQKKSFPIWRNSKLSIQDNIAKAFTSPGLDLLQAMLIYEPSRRITARDALLHPYFSDLDKSLVPATGEEYIGLPLD-QLPREVAAIFLA 333          
BLAST of Cyclin-dependent kinase vs. TrEMBL
Match: A0A183K468 (Protein kinase domain-containing protein OS=Schistosoma curassoni OX=6186 GN=SCUD_LOCUS9786 PE=3 SV=1)

HSP 1 Score: 267.314 bits (682), Expect = 2.562e-82
Identity = 145/328 (44.21%), Postives = 202/328 (61.59%), Query Frame = 1
Query:  115 YRIGDYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKV--KFESMNFQESKNSFNAIKLLKTKV-NSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINAPRKPQVLYLT 1062
            Y + D+  L K+G  +YG VY  KNK N    ALKK++++   EG+P+T +REISLLK LQHPNI+NL QV++ + R+Y++ EY+ + L  +L D      +   +++SFM+Q+LQ   FCH RRV+HRD+K QNILV+   KIVKL DFGL+R  G     LT  VVTL+YR+PE++L    Y   VDIWS+GC+F E+  K   FR D EI   F  F  LG P+++  PG     +++  +F   +NS  +I+    K   S   DL+  M IY P +RI A  ALLH YF D D+S+ PA GEE +G P +   PR+   ++L 
Sbjct:    7 YALSDFIRLEKIGEGTYGVVYKCKNKVNGKFAALKKIRLENDEEGVPSTAIREISLLKELQHPNIVNLEQVIMENGRLYLVFEYLNLDLKRYLDDSGRKNLLEPGIVKSFMYQMLQGLLFCHGRRVIHRDLKPQNILVDIGRKIVKLADFGLARAFGIPVRVLTHEVVTLWYRAPEILLGAQRYSCAVDIWSMGCIFSEVSTKEALFRGDSEIDQLFRIFRLLGTPSEEVWPGVSSLPEYQKKSFPIWRNSKLSIQDNIAKAFTSPGLDLLQAMLIYEPSRRITARDALLHPYFSDLDKSLVPATGEEYIGLPLD-QLPREVAAIFLA 333          
BLAST of Cyclin-dependent kinase vs. Ensembl Cavefish
Match: cdk1 (cyclin dependent kinase 1 [Source:NCBI gene;Acc:103047431])

HSP 1 Score: 223.402 bits (568), Expect = 5.358e-70
Identity = 117/297 (39.39%), Postives = 180/297 (60.61%), Query Frame = 1
Query:  127 DYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPA 990
            DY  + K+G  +YG VY  ++K    + ALKK++++   EG+P+T +REISLLK LQHPN++ L  VL+ + ++Y++ E++ M L  +L        +   L++S+++Q+L+   FCH RRVLHRD+K QN+L+++   ++KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VD+WS+G +F E+  K P F  D EI   F  F  LG PN+D  P  +   +  N      + N   ++K  ++    DL+ +M IY+PLKRI A  A+ H YF D D++  PA
Sbjct:    3 DYMKIEKIGEGTYGVVYKGRHKSTGQVVALKKIRLESEEEGVPSTAVREISLLKELQHPNVVRLLDVLMQESKLYLVFEFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGILFCHCRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGASRYSTPVDVWSIGTIFAELATKKPLFHGDSEIDQLFRIFRILGTPNNDVWPDVESLPDYKNTFPKWKTGNLSSMVKN-LDKNGIDLLGKMLIYDPLKRISARQAMTHPYFDDLDKTTLPA 297          
BLAST of Cyclin-dependent kinase vs. Ensembl Cavefish
Match: cdk1 (cyclin dependent kinase 1 [Source:NCBI gene;Acc:103047431])

HSP 1 Score: 223.402 bits (568), Expect = 5.358e-70
Identity = 117/297 (39.39%), Postives = 180/297 (60.61%), Query Frame = 1
Query:  127 DYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPA 990
            DY  + K+G  +YG VY  ++K    + ALKK++++   EG+P+T +REISLLK LQHPN++ L  VL+ + ++Y++ E++ M L  +L        +   L++S+++Q+L+   FCH RRVLHRD+K QN+L+++   ++KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VD+WS+G +F E+  K P F  D EI   F  F  LG PN+D  P  +   +  N      + N   ++K  ++    DL+ +M IY+PLKRI A  A+ H YF D D++  PA
Sbjct:    3 DYMKIEKIGEGTYGVVYKGRHKSTGQVVALKKIRLESEEEGVPSTAVREISLLKELQHPNVVRLLDVLMQESKLYLVFEFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGILFCHCRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGASRYSTPVDVWSIGTIFAELATKKPLFHGDSEIDQLFRIFRILGTPNNDVWPDVESLPDYKNTFPKWKTGNLSSMVKN-LDKNGIDLLGKMLIYDPLKRISARQAMTHPYFDDLDKTTLPA 297          
BLAST of Cyclin-dependent kinase vs. Ensembl Cavefish
Match: cdk2 (cyclin dependent kinase 2 [Source:NCBI gene;Acc:103028318])

HSP 1 Score: 217.238 bits (552), Expect = 1.160e-67
Identity = 121/288 (42.01%), Postives = 173/288 (60.07%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSS---NLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESM-NFQES--KNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAP 987
            G+YG VY AKNK      ALKK+++D   EG+P+T +REISLLK L HPNI+ L  V+ ++ ++Y++ E++   L  F+    V+     L++S++FQLLQ  AFCH+ RVLHRD+K QN+L+N   +I KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VDIWSLGC+F EM+ +   F  D EI   F  F  LG P++   PG      SM +++ S  K +   +  +   ++    DL+ QM  Y+P KRI A  AL+H +F D    + P
Sbjct:   16 GTYGVVYKAKNKITGETVALKKIRLDTETEGVPSTAIREISLLKELSHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDSSSVTGISLPLVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAQGEI-KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPDETVWPGVT----SMPDYKPSFPKWALQDLAKVVPPLDEDGRDLLGQMLNYDPNKRISAKNALVHRFFRDVTMPMPP 298          
BLAST of Cyclin-dependent kinase vs. Ensembl Cavefish
Match: cdk1 (cyclin dependent kinase 1 [Source:NCBI gene;Acc:103047431])

HSP 1 Score: 193.356 bits (490), Expect = 1.765e-58
Identity = 114/301 (37.87%), Postives = 170/301 (56.48%), Query Frame = 1
Query:  127 DYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSSNLLQSFMFQLLQ------ATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKL--LKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPA 990
            DY  + K+G  +YG VY  ++K    + ALKK++++   EG+P+T +REISLLK LQHPN++ L  VL+ + ++Y++ E++ M L  +L D   S   +   +  L+          FCH RRVLHRD+K QN+L+++   ++KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VD+WS+G +F E+  K P F  D EI   F  F  LG PN+D  P  +      +  + KN+F   K   L + V +   + I    + N L RI A  A+ H YF D D++  PA
Sbjct:    3 DYMKIEKIGEGTYGVVYKGRHKSTGQVVALKKIRLESEEEGVPSTAVREISLLKELQHPNVVRLLDVLMQESKLYLVFEFLSMDLKKYL-DSIPSGQYMDPMLVDLINLCVSSCGILFCHCRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGASRYSTPVDVWSIGTIFAELATKKPLFHGDSEIDQLFRIFRILGTPNNDVWPDVE------SLPDYKNTFPKWKTGNLSSMVKNLDKNGIDLSNVLNLLCRISARQAMTHPYFDDLDKTTLPA 295          
BLAST of Cyclin-dependent kinase vs. Ensembl Cavefish
Match: cdk5 (cyclin dependent kinase 5 [Source:NCBI gene;Acc:103032107])

HSP 1 Score: 189.504 bits (480), Expect = 4.661e-57
Identity = 107/291 (36.77%), Postives = 168/291 (57.73%), Query Frame = 1
Query:  130 YAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLR--DFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPF----RVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDF 969
            Y  L K+G  +YG V+ AKN++   + ALK++++D   EG+P++ LREI LLK L+H NI+ LH VL SDK++ ++ EY    L  +    + D+   +++SFM+QLL+  AFCH+R VLHRD+K QN+L+N + ++ KL DFGL+R  G      +  VVTL+YR P+++    +Y + +D+WS GC+F E+     P      VD +++  F     LG P ++       K           +  ++  +  K++S   DL+  +   NP++RI A  AL H YF DF
Sbjct:    4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEYCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGEL-KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRL---LGTPTEEQW-QTMTKLPDYKPYPMYPATTSLVNVVPKLSSTGRDLLQNLLKCNPVQRISAEEALQHPYFADF 289          
BLAST of Cyclin-dependent kinase vs. Ensembl Sea Lamprey
Match: cdk2 (cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2741])

HSP 1 Score: 212.231 bits (539), Expect = 1.649e-66
Identity = 114/285 (40.00%), Postives = 172/285 (60.35%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRD---FDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTK--VNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSV 981
            G+YG VY A++K      ALKK+++D   EG+P+T +REI+LL+ L HPNI+ L  V+ S+ ++Y++ E++   L  ++ +     +S  L++S+M QLLQ  AFCH +R LHRD+K QN+L+N    I KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VD+WSLGC+F EM+ +   F  D EI   F  F  LG P++    G     +  +++ S   + A  L K    +++   DL+MQM  Y+P +R+ A AAL H +FH+ +  V
Sbjct:   13 GTYGVVYKARHKMTGDTVALKKIRLDTETEGVPSTAIREIALLRELNHPNIVRLLDVIHSETKLYLVFEFLDQDLKKYMDNAPPLGISLPLVKSYMHQLLQGIAFCHAQRTLHRDLKPQNLLINADGAI-KLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGCKYYSTAVDVWSLGCIFAEMLTRRALFPGDSEIDQLFRIFRTLGTPDETVWQGIT---QLPDYKPSFPRWCAQDLTKVVPLLDAAGHDLLMQMLQYDPTRRVSAKAALNHHFFHNLEHHV 293          
BLAST of Cyclin-dependent kinase vs. Ensembl Sea Lamprey
Match: cdk1 (cyclin-dependent kinase 1 [Source:ZFIN;Acc:ZDB-GENE-010320-1])

HSP 1 Score: 206.838 bits (525), Expect = 1.481e-64
Identity = 116/291 (39.86%), Postives = 164/291 (56.36%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSSNLL------QSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSF-----NAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSV 981
            GSYG VY  +NK    L ALKK++++   EG+P T +REI+LL+ L+HPNI+ L  VL+   R+Y+I EY+ M L  +L        +       QS++ Q+LQA  FCH+RRVLHRD+K QN+L++    I KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VD+WS+G +  EMV K P F  D EI   F  F  LG P  +  P      + +   + K SF     + +      +N    DL+ +M  Y+P +RI A  AL H YF + + +V
Sbjct:    1 GSYGVVYKGRNKGTGDLVALKKIRLEHEEEGVPATAIREIALLRELRHPNIVRLQDVLLQSARLYLIFEYLPMDLKRYLDAIPAGHCMEPPLIQGQSYLHQILQAVVFCHSRRVLHRDLKPQNLLIDRHGHI-KLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGTPRYSTPVDMWSVGTILAEMVNKRPLFHGDSEIDQLFRIFRILGTPTTEVWP------DVVTLPDYKPSFPKWVPSGLVAHVPGLNQDGIDLLEKMLTYDPARRISAKRALTHPYFQNEESAV 284          
BLAST of Cyclin-dependent kinase vs. Ensembl Sea Lamprey
Match: cdk2 (cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2741])

HSP 1 Score: 201.445 bits (511), Expect = 2.298e-62
Identity = 112/284 (39.44%), Postives = 172/284 (60.56%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSS---NLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPG-AKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSV 981
            G+YG VY A+NK      ALKK+++D   EG+P+T +REISLL+ L HPNI+ L  ++ S+K++Y++ E +   L  F+ +   S     L++S+++QLLQ  AFCH+ R+LHRD+K QN+L+N +   +KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VD+WS+GC+F EM+ +   F  D EI   F  F  LG P++   PG +++      F    N     K++ T +N +  DL+  M  Y+P +R+ A+ AL H +F +  + V
Sbjct:   13 GTYGVVYKARNKLTGEAVALKKIRLDTETEGVPSTAIREISLLRELNHPNIVRLLTIIHSEKKLYLVFELLDQDLKKFMDNATPSGIPLPLVKSYLYQLLQGIAFCHSHRILHRDLKPQNLLIN-AEGAIKLADFGLARAFGVPQRTYTHEVVTLWYRAPEILLGCKHYSTSVDVWSIGCIFAEMLTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVSQLPDYKSTFPRWANQ-ELTKVVPT-LNFEGRDLLALMLQYDPNQRVTANMALSHCFFQNVKQIV 293          
BLAST of Cyclin-dependent kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008013.1 (pep scaffold:Pmarinus_7.0:GL478839:10839:40406:1 gene:ENSPMAG00000007231.1 transcript:ENSPMAT00000008013.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 180.644 bits (457), Expect = 2.473e-52
Identity = 106/295 (35.93%), Postives = 166/295 (56.27%), Query Frame = 1
Query:  130 YAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID--EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD--VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPF---RVDGEIQLFFSWFTQLGVPNDDDMPG--AKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSV 981
            Y  L KLG  +Y  VY  ++K    L ALK+++++  EG P T +RE+SLLK L+H NI+ LH ++ +DK + ++ EY++  L  ++ D    +S + ++ F+ QLL+  A+CH RRVLHRD+K QN+L+N   ++ KL DFGL+R         +  VVTL+YR P+++L    Y + +D+W +GC+F EM    P F    V+ E+ L F     LG P +D  PG  +  +++S NF + ++        +  V+    DL+ +  +Y    RI A  AL   YF  F   V
Sbjct:  198 YTKLDKLGEGTYATVYKGRSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLEKDLKQYMDDCGNIMSMHNVKIFLLQLLRGLAYCHKRRVLHRDLKPQNLLINDKGEL-KLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTQIDMWGVGCIFFEMAAGRPLFPGSTVEDELHLIFRM---LGSPREDMWPGISSNEEYKSYNFPKYRSEPMITHAPRLDVDG--LDLLSKFLLYEAKARISAEDALKRPYFKSFGEEV 486          
BLAST of Cyclin-dependent kinase vs. Ensembl Sea Lamprey
Match: cdk4 (cyclin-dependent kinase 4 [Source:ZFIN;Acc:ZDB-GENE-060929-974])

HSP 1 Score: 161.77 bits (408), Expect = 8.807e-47
Identity = 102/289 (35.29%), Postives = 165/289 (57.09%), Query Frame = 1
Query:  148 LGSYGRVYLAKNKQNKFLY-ALKKLKI---DEGIPTTTLREISLLKILQ---HPNIINLHQVLVSDK-----RIYMIMEYMKMSLNLFLRDF---DVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMP-GAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHD 966
            +G+YG VY A++ QN+  + ALKK+++   +EG+P +T+RE++LL+ L+   HPN++ L  V  + +     R+ ++ E++   L+ +L       + ++ ++  M QLL    F H  RV+HRD+K QNILV    + VKL DFGL+R   F    LT  VVTL+YR+PE++L    Y + VD+WS+GC+F EM  + P F    +       F  LG+PN DD P    + + S  ++  +    A+K    ++     +L++++  +NP KRI A +AL   YF D
Sbjct:   23 VGAYGTVYKARDLQNEGRFVALKKVRVQTGEEGMPLSTIREVALLRQLETFEHPNVVRLFDVCATSRTDRETRLTLVFEHVDQDLSTYLEKAPAPGLPADKIKDMMHQLLSGLDFLHTHRVVHRDLKPQNILVTSDGQ-VKLADFGLARIYSFQMA-LTSVVVTLWYRAPEVLLQSS-YATTVDLWSVGCIFAEMFRRRPLFCGSSDFDQLTKIFDLLGLPNRDDWPQDVSLPYTSFAYRPPQ----ALKNFVPEMGPLGEELLLKLLTFNPSKRISALSALQQPYFSD 304          
BLAST of Cyclin-dependent kinase vs. Ensembl Yeast
Match: CDC28 (Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1, S, G2/M phase cyclins, which provide substrate specificity; regulates metabolism, basal transcription, chromosome dynamics, growth and morphogenesis; transcript induction in osmostress involves antisense RNA; human homologs CDK1, CDK2, CDK3 can complement yeast conditional cdc28 mutants; human CDK1, CDK2 can complement yeast cdc28 null mutant [Source:SGD;Acc:S000000364])

HSP 1 Score: 189.889 bits (481), Expect = 4.986e-58
Identity = 107/300 (35.67%), Postives = 175/300 (58.33%), Query Frame = 1
Query:  121 IGDYAILSKLG--SYGRVYLA---KNKQNKFLYALKKLKI---DEGIPTTTLREISLLKILQHPNIINLHQVLVSDK-RIYMIMEYMKMSLNLFL----RDFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSF-----NAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHD 966
            + +Y  L K+G  +YG VY A   +  Q + + ALKK+++   DEG+P+T +REISLLK L+  NI+ L+ ++ SD  ++Y++ E++ + L  ++    +D  + +++++ FM QL +  A+CH+ R+LHRD+K QN+L+N    + KL DFGL+R  G      T  +VTL+YR+PE++L    Y +GVD WS+GC+F EM  + P F  D EI   F  F  LG PN+   P      + +   + K SF       +  +   ++ +  DL+ ++  Y+P+ RI A  A +H YF +
Sbjct:    5 LANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNL-KLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWP------DIVYLPDFKPSFPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQE 297          
BLAST of Cyclin-dependent kinase vs. Ensembl Yeast
Match: PHO85 (Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissencephaly-associated homolog CDK5 functionally complements null mutation [Source:SGD;Acc:S000005952])

HSP 1 Score: 169.859 bits (429), Expect = 2.606e-50
Identity = 98/300 (32.67%), Postives = 158/300 (52.67%), Query Frame = 1
Query:  109 QLYRIGDYAILSKLGSYGRVYLAKNKQNKFLYALKKLKID--EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSS-------NLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAK--VKFESMNFQESKNSFNAIKLLKTK--VNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDF 969
            QL ++G+       G+Y  VY   NK      ALK++K+D  EG P+T +REISL+K L+H NI+ L+ V+ ++ ++ ++ E+M   L  ++    V +       NL++ F +QLLQ  AFCH  ++LHRD+K QN+L+N   ++ KL DFGL+R  G      +  VVTL+YR+P++++    Y + +DIWS GC+  EM+   P F    + +     F  +G PN+   P      K+     Q        +    TK  ++    D +  +   NP  R+ A  AL H +F ++
Sbjct:    9 QLEKLGN-------GTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQL-KLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY 300          
BLAST of Cyclin-dependent kinase vs. Ensembl Yeast
Match: CTK1 (Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; required for H3K36 trimethylation but not dimethylation by Set2p; suggested stimulatory role in 80S formation during translation initiation; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13 [Source:SGD;Acc:S000001622])

HSP 1 Score: 161.77 bits (408), Expect = 3.718e-45
Identity = 103/286 (36.01%), Postives = 157/286 (54.90%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLV-SDKRIYMIMEYMKMSLNLFL--RDFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDD------DMPGAKVKFESMNFQESK--NSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHD 966
            G+YG+VY AKN   + L ALKKL++    EG P T++REI LL+   HPN+  + +++V S K +YMI EY    L+  L  ++  +S +  +    QLL    + H+ ++LHRD+K  NIL+++   + K+ DFGL+RK+       T  V+TL+YR PEL+L    Y + VD+W  GC+ VE+  K   F+   E++   S F  +G P  +      DMP     F  M  Q +K  N+F+  K      +SKC  L + +  Y+  KR  A+ AL  +YF +
Sbjct:  192 GTYGKVYKAKNTNTEKLVALKKLRLQGEREGFPITSIREIKLLQSFDHPNVSTIKEIMVESQKTVYMIFEYADNDLSGLLLNKEVQISHSQCKHLFKQLLLGMEYLHDNKILHRDVKGSNILIDNQGNL-KITDFGLARKMN-SRADYTNRVITLWYRPPELLLGTTNYGTEVDMWGCGCLLVELFNKTAIFQGSNELEQIESIFKIMGTPTINSWPTLYDMPWF---FMIMPQQTTKYVNNFSE-KFKSVLPSSKCLQLAINLLCYDQTKRFSATEALQSDYFKE 471          
BLAST of Cyclin-dependent kinase vs. Ensembl Yeast
Match: FUS3 (Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its; inhibits recruitment of Ste5p, Cdc42p-mediated asymmetry and mating morphogenesis [Source:SGD;Acc:S000000112])

HSP 1 Score: 140.198 bits (352), Expect = 1.449e-38
Identity = 93/294 (31.63%), Postives = 148/294 (50.34%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLK-IDEGI-PTTTLREISLLKILQHPNIINLHQVLVSDK-----RIYMIMEYMKMSLNLFLRDFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGR----------LTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLK--TKVNSKCFDLIMQMFIYNPLKRIGASAALLHEY---FHD 966
            G+YG V  A +K    + A+KK++  D+ +    TLREI +LK  +H NII +  +   D       +Y+I E M+  L+  +    +S + +Q F++Q L+A    H   V+HRD+K  N+L+N +  + K+CDFGL+R I                +T  V T +YR+PE++L    Y   +D+WS GC+  E+ L+ P F            F  +G P+ D+         +  + +S   + A  L K   +VN K  DL+ +M +++P KRI A  AL H Y   +HD
Sbjct:   22 GAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDL-KVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHD 314          
BLAST of Cyclin-dependent kinase vs. Ensembl Yeast
Match: KIN28 (Serine/threonine protein kinase, subunit of transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters; phosphorylates Ser5 residue of the PolII C-terminal domain (CTD) at gene promoters; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000002266])

HSP 1 Score: 135.576 bits (340), Expect = 2.493e-37
Identity = 83/287 (28.92%), Postives = 141/287 (49.13%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKIDE---GIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDV--SSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQE--SKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPA 990
            G+Y  VYL          A+K++K  E   G+  + +RE+  L+ +QHPN+I L  + ++   + +++E++   L + ++D  +  +   ++++M   L+    CH   +LHRD+K  N+L +   +I K+ DFGL+R I      LT  VVT +YR+PEL+     Y S +DIWS+G +F E++L+ P      ++      F  LG P D D P     F + N  +     S + ++      +    D +  M   NP KR  A   L  +YF +      P+
Sbjct:   16 GTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEMQHPNVIELIDIFMAYDNLNLVLEFLPTDLEVVIKDKSILFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQI-KVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVDQMEVTFRALGTPTDRDWPEVS-SFMTYNKLQIYPPPSRDELRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLESDYFKELPPPSDPS 300          
BLAST of Cyclin-dependent kinase vs. Ensembl Nematostella
Match: EDO41403 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4F0])

HSP 1 Score: 218.009 bits (554), Expect = 1.951e-68
Identity = 114/285 (40.00%), Postives = 174/285 (61.05%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLF---LRDFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQES--KNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSV 981
            G+YG VY A++K    + ALKK+++D   EG+P+T +REISLLK L HPN+++L  V+ + K +Y++ E++   L  +   L    +S++L++S+++QLL   A+CH+ RVLHRD+K QN+L++ +  I KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VD+WS+GC+F EM  +   F  D EI   F  F  LG P+D   PG     E  +++ S  K    +I+ +   +++   DL+ +M  Y P  RI A AAL HE+F D  R +
Sbjct:   13 GTYGVVYKARDKTTGRMVALKKIRLDTESEGVPSTAIREISLLKELNHPNVVSLLDVVHNQKSLYLVFEFLSQDLKKYMDCLPPSGISTSLIKSYVYQLLSGVAYCHSHRVLHRDLKPQNLLIDKNGAI-KLADFGLARAFGVPVRSYTHEVVTLWYRAPEILLGSRYYATPVDVWSIGCIFAEMKTRRALFPGDSEIDQLFRIFRTLGTPDDKVWPGVS---ELPDYKTSFPKWPVQSIRHVLPTLDNTAIDLLQKMLTYQPNARISAKAALSHEFFKDVQRKI 293          
BLAST of Cyclin-dependent kinase vs. Ensembl Nematostella
Match: EDO43671 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXS1])

HSP 1 Score: 200.675 bits (509), Expect = 1.065e-61
Identity = 111/286 (38.81%), Postives = 166/286 (58.04%), Query Frame = 1
Query:  127 DYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKI---DEGIPTTTLREISLLKILQH-PNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD--VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYF 960
            D++ + K+G  +YG VY AKN +     ALKK+++   DEGIP+T +REISLLK L+H PN++ L  +L  + ++Y++ EY+   L   L      +   L++S+++Q+  A  FCH RR+LHRD+K QN+L++ S  ++KL DFGL R  G      T  VVTL+YR+PE++L    Y   +D+WS+G +F EMV K P F  D EI   F  F  LG P ++   G             K + + +K    +++S   DL+ +M IY+P  RI A  +L H YF
Sbjct:    3 DFSKIEKIGEGTYGVVYKAKNLKTGGFAALKKIRLEVEDEGIPSTAVREISLLKELRHHPNVVELQHILHQEPKLYLVFEYLTCDLKKHLDTTRGMLDKTLVKSYLYQITNAIYFCHARRILHRDLKPQNLLID-SKGLIKLADFGLGRAFGIPVRAYTHEVVTLWYRAPEVLLGGQRYSCPIDVWSIGTIFAEMVTKRPLFHGDSEIDQLFRIFRILGTPTEETWKGV-TSLPDYKPTFPKWAGDGLKKAVPQLDSDGLDLLKKMLIYDPALRISAKTSLKHPYF 286          
BLAST of Cyclin-dependent kinase vs. Ensembl Nematostella
Match: EDO49420 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGF7])

HSP 1 Score: 189.889 bits (481), Expect = 1.303e-57
Identity = 102/282 (36.17%), Postives = 166/282 (58.87%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDF--DVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPF----RVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDF 969
            G+YG V+  KNK+ + + ALK++++D   EG+P++ LREI LLK L+H NI+ L+ VL S+K++ ++ E+    L  +      +V +++++SFMFQLL+  AFCH+  VLHRD+K QN+L+N   ++ KL DFGL+R  G      +  VVTL+YR P++++   +Y + +D+WS GC+F EM     P      VD +++  F     LG P ++  P      +   F     S  ++ ++  K++S   DL+ ++ + NP  RI A  A+ H YF D 
Sbjct:   13 GTYGTVFKGKNKETREILALKRVRLDDDDEGVPSSALREICLLKELKHNNIVRLYDVLHSEKKLTLVFEFCDQDLKKYFDSCQGEVDASVVKSFMFQLLRGLAFCHSHNVLHRDLKPQNLLINKDGEL-KLADFGLARAFGIPVRCFSAEVVTLWYRPPDVLMGAKLYSTSIDMWSAGCIFAEMANGGRPLFPGNDVDDQLRRIFKI---LGTPTEESWPNVSKLPDYKEFPPQGPSV-SLGMVVPKLSSTGRDLLQKLLVSNPAHRISAEDAMKHAYFADL 289          
BLAST of Cyclin-dependent kinase vs. Ensembl Nematostella
Match: EDO40841 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5Y1])

HSP 1 Score: 185.652 bits (470), Expect = 1.044e-53
Identity = 105/298 (35.23%), Postives = 167/298 (56.04%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDK--RIYMIMEYMKMSLNLFLRDFDV--SSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGA----------KVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAI 993
            G+YG VY AK K +  + ALK+LK++   EG P T+LREI+ L   QHPNI+++ +++V     RIY++M+Y++  L   +       +   +++ + QLL+ATA  H+  +LHRD+K+ N+L+N+   +  + DFGL+R+ G      TP VVTL+YR+PEL+L    Y   +D+WS+GC+F E++   P F    EI      F +LG P+D   PG           K+ F    + + +N F       T +  K F L+ +   Y+P KRI A  AL  +YF +  + + P++
Sbjct:  159 GTYGVVYRAKEKASGEVVALKRLKMEKEKEGFPITSLREINTLLKAQHPNIVHVREIVVGSNMDRIYIVMDYVEHDLKTLMEHMTSPFTVGEVKTLLIQLLRATAHLHDNWILHRDLKTSNLLLNNRGILKVVGDFGLAREYGSPLRHYTPIVVTLWYRAPELLLGIKEYSCPIDMWSVGCIFAELLTMEPLFPGRSEIDQINRIFKELGTPSDKIWPGPPAYSELPHVKKMTFTEYPYNQLRNRFG------TYLTDKGFSLLNRFLTYDPKKRITAETALKEDYFLEAPKPIDPSL 450          
BLAST of Cyclin-dependent kinase vs. Ensembl Nematostella
Match: EDO48117 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RK70])

HSP 1 Score: 166.777 bits (421), Expect = 1.846e-48
Identity = 100/289 (34.60%), Postives = 164/289 (56.75%), Query Frame = 1
Query:  130 YAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID--EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD--VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPF---RVDGEIQLFFSWFTQLGVPNDDDMPG--AKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFH 963
            Y  L KLG  +Y  V+  K+K    + ALK+++++  EG P T +RE+SLLK L+H NI+ LH  + + K + ++ EY++  L  ++ D    +S N ++ F+FQLL+   +CH R+VLHRD+K QN+L+N   ++ KL DFGL+R         +  VVTL+YR P+++L    Y + +D+W +GC+F EM    P F    V+ E+ L F     LG P+++  PG  A   F +  F +     N I +   ++++   +L+ +   Y    R+ A  A+ H+YF+
Sbjct:   11 YTKLDKLGEGTYATVFKGKSKLTDNIVALKEIRLEHEEGAPCTAIREVSLLKGLKHANIVTLHDTVHTQKSLTLVFEYLEKDLKQYMDDCGGIMSMNNVRIFLFQLLRGLDYCHKRKVLHRDLKPQNLLINDKGEL-KLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTAYSTQIDMWGVGCIFFEMATGRPLFPGSTVEDELLLIFK---VLGTPSEEVWPGISANEAFIAGKFPDYPRE-NLI-IHAPRLDNSGLELLEKFLEYTVKDRVSAHDAMRHDYFY 293          
BLAST of Cyclin-dependent kinase vs. Ensembl Medaka
Match: cdk1 (cyclin dependent kinase 1 [Source:NCBI gene;Acc:100049478])

HSP 1 Score: 223.402 bits (568), Expect = 4.720e-70
Identity = 116/302 (38.41%), Postives = 180/302 (59.60%), Query Frame = 1
Query:  127 DYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFD----VSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSF-----NAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPA 990
            DY  + K+G  +YG VY  ++K    + A+KK++++   EG+P+T +RE+SLL+ L+HPN++ L  VL+ + R+Y+I E++ M L  +L        +   L++S+++Q+L+   FCH RRVLHRD+K QN+L+++   ++KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VD+WS G +F E+  K P F  D EI   F  F  LG PN+D  P  +      +  + KN+F      ++  +   ++    DL+ +M IYNP KRI A  A+ H YF D D+S  PA
Sbjct:    3 DYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLLDVLMQESRLYLIFEFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNK-GVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPNNDVWPDVE------SLPDYKNTFPKWKEGSLSSMVKNLDKNGLDLLAKMLIYNPPKRISAREAMTHPYFDDLDKSTLPA 297          
BLAST of Cyclin-dependent kinase vs. Ensembl Medaka
Match: cdk2 (cyclin dependent kinase 2 [Source:NCBI gene;Acc:101161880])

HSP 1 Score: 213.386 bits (542), Expect = 3.042e-66
Identity = 117/281 (41.64%), Postives = 170/281 (60.50%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSS---NLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESM-NFQESKNSFNAIKLLKTK--VNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHD 966
            G+YG VY AKNK      ALKK+++D   EG+P+T +REISLLK L HPNI+ L  V+ ++ ++Y++ E++   L  F+    V+     L++S++FQLLQ  AFCH+ RVLHRD+K QN+L+N   +I KL DFGL+R  G      T  VVTL+YR+PE++L    Y + VD+WSLGC+F EM+ +   F  D EI   F  F  LG P++   PG      SM +++ S   +    L K    ++    +L+ +M  Y+P KR+ A  AL+H +F D
Sbjct:   13 GTYGVVYKAKNKLTGETVALKKIRLDTETEGVPSTAIREISLLKELSHPNIVKLQDVIHTENKLYLVFEFLHQDLKKFMDSSSVTGIPLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAQGEI-KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDVWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPDETAWPGVT----SMPDYKPSFPKWARQDLSKVVPLLDEDGRELLGEMLKYDPNKRLSAKNALVHRFFRD 288          
BLAST of Cyclin-dependent kinase vs. Ensembl Medaka
Match: cdk5 (cyclin dependent kinase 5 [Source:NCBI gene;Acc:101174461])

HSP 1 Score: 190.66 bits (483), Expect = 1.772e-57
Identity = 107/291 (36.77%), Postives = 168/291 (57.73%), Query Frame = 1
Query:  130 YAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLR--DFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPF----RVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDF 969
            Y  L K+G  +YG V+ AKN++   + ALK++++D   EG+P++ LREI LLK L+H NI+ LH VL SDK++ ++ EY    L  +    + D+    ++SFM+QLL+  AFCH+R VLHRD+K QN+L+N + ++ KL DFGL+R  G      +  VVTL+YR P+++    +Y + +D+WS GC+F E+     P      VD +++  F     LG P ++  P    K           +  ++  +  K+++   DL+  +   NP++RI A  AL H YF DF
Sbjct:    4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEYCDQDLKKYFDSCNGDLDPETVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGEL-KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRL---LGTPTEEQWP-TMTKLPDYKPYPMYPATTSLVNVVPKLSNTGRDLLQNLLKCNPVQRISAEEALQHPYFADF 289          
BLAST of Cyclin-dependent kinase vs. Ensembl Medaka
Match: cdk11b (cyclin-dependent kinase 11B [Source:NCBI gene;Acc:101154777])

HSP 1 Score: 184.882 bits (468), Expect = 1.319e-51
Identity = 106/295 (35.93%), Postives = 165/295 (55.93%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDK--RIYMIMEYMKMSLNLFLRDFDVS--SNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPG-------AKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAI 993
            G+YG VY AK+K+   + ALK+LK++   EG P T+LREI+ +   QHPNI+ + +++V     +IY++M Y++  L   +           +++ M QLL+     H+  +LHRD+K+ N+L++H   I+K+ DFGL+R+ G      TP VVTL+YRSPEL+L    Y + VD+WS+GC+F E++ + P F    EI      F  LG P+D   PG        K+ F    +   +  F A+      ++ + FDL+     Y P KRI + AAL HEYF +    + P++
Sbjct:  385 GTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVRHLHDNWILHRDLKTSNLLLSHKG-ILKIGDFGLAREYGSPLKPYTPIVVTLWYRSPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKIFKDLGSPSDKIWPGYSELPAVKKMTFTEYPYNNLRKRFGAL------LSDQGFDLMNTFLTYCPSKRILSDAALKHEYFRESPLPIDPSM 672          
BLAST of Cyclin-dependent kinase vs. Ensembl Medaka
Match: cdk6 (cyclin dependent kinase 6 [Source:NCBI gene;Acc:101168879])

HSP 1 Score: 176.022 bits (445), Expect = 1.931e-51
Identity = 107/298 (35.91%), Postives = 169/298 (56.71%), Query Frame = 1
Query:  151 GSYGRVYLAKNKQNKFLY-ALKKLKI---DEGIPTTTLREISLLKILQ---HPNIINLHQVLV-----SDKRIYMIMEYMKMSLNLFLR---DFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFD---RSVAPA 990
            G+YG+VY A++ +N+  + ALK++++   +EG+P +T+RE+++L+ L+   HPN++ L  V        + ++ ++ E++   L  +L    D  V    ++  M+QLLQ   F H+ RV+HRD+K QNILV    +I KL DFGL+R   F    LT  VVTL+YR+PE++L    Y + VD+WS+GC+F EM  + P FR + ++      F  +GVP+ +D P  +V      F  +      I+ L   ++ +   L+MQ   +NP +RI A  AL H YF   D   RSV  A
Sbjct:   19 GAYGKVYKARDLKNEGRFVALKRVRVQTEEEGMPLSTIREVAVLRQLEAFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLEKVPDPGVPPETIKDMMYQLLQGLDFLHSHRVVHRDLKPQNILVTSGGQI-KLADFGLARIYSFQMA-LTSVVVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRRPLFRGNSDVDQLGKIFDVVGVPSAEDWP-QEVALPQSAF--TPRPPKPIEDLVPDIDEQGQALLMQFLAFNPSRRISAFTALSHPYFQSLDSHSRSVYAA 310          
BLAST of Cyclin-dependent kinase vs. Planmine SMEST
Match: SMESG000023609.1 (SMESG000023609.1)

HSP 1 Score: 724.161 bits (1868), Expect = 0.000e+0
Identity = 349/349 (100.00%), Postives = 349/349 (100.00%), Query Frame = 1
Query:   64 MNTQEIDILFTDIPHQLYRIGDYAILSKLGSYGRVYLAKNKQNKFLYALKKLKIDEGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINAPRKPQVLYLTTDHLEGLNDQGNMETK 1110
            MNTQEIDILFTDIPHQLYRIGDYAILSKLGSYGRVYLAKNKQNKFLYALKKLKIDEGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINAPRKPQVLYLTTDHLEGLNDQGNMETK
Sbjct:    1 MNTQEIDILFTDIPHQLYRIGDYAILSKLGSYGRVYLAKNKQNKFLYALKKLKIDEGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINAPRKPQVLYLTTDHLEGLNDQGNMETK 349          
BLAST of Cyclin-dependent kinase vs. Planmine SMEST
Match: SMESG000023609.1 (SMESG000023609.1)

HSP 1 Score: 718.768 bits (1854), Expect = 0.000e+0
Identity = 349/351 (99.43%), Postives = 349/351 (99.43%), Query Frame = 1
Query:   64 MNTQEIDILFTDIPHQLYRIGDYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKIDEGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINAPRKPQVLYLTTDHLEGLNDQGNMETK 1110
            MNTQEIDILFTDIPHQLYRIGDYAILSKLG  SYGRVYLAKNKQNKFLYALKKLKIDEGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINAPRKPQVLYLTTDHLEGLNDQGNMETK
Sbjct:    1 MNTQEIDILFTDIPHQLYRIGDYAILSKLGRGSYGRVYLAKNKQNKFLYALKKLKIDEGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINAPRKPQVLYLTTDHLEGLNDQGNMETK 351          
BLAST of Cyclin-dependent kinase vs. Planmine SMEST
Match: SMESG000023590.1 (SMESG000023590.1)

HSP 1 Score: 645.58 bits (1664), Expect = 0.000e+0
Identity = 311/327 (95.11%), Postives = 319/327 (97.55%), Query Frame = 1
Query:   64 MNTQEIDILFTDIPHQLYRIGDYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKIDEGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINAPR 1038
            MN QEIDIL TD  HQLYRIGDYAILSKLG  +YGRVYLAKNKQNKFLYA+KK+KID+GIPTTTLRE+SLLKILQHPNIINLHQVLVSDKRIYM+MEYMKMSLNLFLRDFDVS ++LQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINAP 
Sbjct:    1 MNNQEIDILHTDTYHQLYRIGDYAILSKLGRGTYGRVYLAKNKQNKFLYAIKKIKIDDGIPTTTLREVSLLKILQHPNIINLHQVLVSDKRIYMVMEYMKMSLNLFLRDFDVSPDMLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINAPE 327          
BLAST of Cyclin-dependent kinase vs. Planmine SMEST
Match: SMESG000052421.1 (SMESG000052421.1)

HSP 1 Score: 235.728 bits (600), Expect = 1.637e-74
Identity = 126/325 (38.77%), Postives = 188/325 (57.85%), Query Frame = 1
Query:   88 LFTDIPHQLYRIGDYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSSN--LLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEINAPRK 1041
            + TD  +  + I D+  + K+G  +YG VY  KNK+     ALKK++++   +G+P+T +REISLLK L HPNI+ L Q ++ D +++++ EY+ M L  +L +   S +  +++ F++Q+LQ   FCH RRV+HRD+K QN+LV+ +  I+KL DFGL+R  G     LT  VVTL+YR+PE+++    Y   VD+WS+ C+F EM    P FR D EI   F  F  LG P ++  PG        +      +       K  ++    DLI +M +YNP  RI +  ALLH YF + +RS  PA GEE+   P E +   K
Sbjct:    1 MATDNNNVKFSISDFIKIEKIGEGTYGVVYKGKNKKTGDFAALKKIRLENDEDGVPSTAIREISLLKELIHPNIVTLKQSMMQDGKLFLVFEYLNMDLRRYLDNLQCSMDPMVIKCFVYQILQGLLFCHLRRVIHRDLKPQNLLVDATGTIIKLADFGLARTFGVPVKALTHEVVTLWYRAPEILMGSKRYSCAVDVWSVACIFAEMATTKPLFRGDSEIDQIFKIFHLLGTPTENHWPGVSHLSSWNSMLPLWTTSRLCSHFKDFMSPDGLDLISEMLLYNPPDRINSRDALLHSYFANLNRSQLPAHGEEHRASPFEASQKSK 325          
BLAST of Cyclin-dependent kinase vs. Planmine SMEST
Match: SMESG000052413.1 (SMESG000052413.1)

HSP 1 Score: 221.476 bits (563), Expect = 4.530e-69
Identity = 121/312 (38.78%), Postives = 182/312 (58.33%), Query Frame = 1
Query:  115 YRIGDYAILSKLG--SYGRVYLAKNKQNKFLYALKKLKID---EGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMSLNLFLRDFDVSSN--LLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSMKIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWSLGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMNFQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFHDFDRSVAPAIGEENVGFPEEIN 1029
            Y++ D+  + K+G  +YG VY + NK      A+KK++ +   +GI  TTLREIS+LK L+HPNI+ L Q +    ++Y++ EY+ M L  +L + +   N  +L+ F +Q++Q   +CH RR +HRD+K QN+LV+ +  I+KL DFGL+R  G     LT  VVTL+YR+PE+ILN   Y   +D+WS+ C+  EM+   P FR D EI   F+ F  LG P++   P    KF   N       ++    L   ++   FDL+ +M +Y+PL+R     ALLH+YF D D+S  PA   E   + + IN
Sbjct:    3 YQLSDFTRIEKIGEGTYGIVYKSINKITNEFAAIKKIRSENDEDGIAPTTLREISILKELRHPNIVYLQQTIAEKGKLYLVFEYLNMDLRRYLDNEENPMNDIILKKFSYQIMQGLLYCHTRRFMHRDLKPQNLLVDTNKHIIKLADFGLARCYGAPVKNLTHEVVTLWYRAPEVILNAKRYSCAIDVWSVACIMAEMITYKPLFRGDSEIDQLFAIFKVLGTPDNKVWPDLD-KFPGWNPLFPVWRYDLRSRLVEVIDENLFDLLEKMLVYHPLERTNIRDALLHDYFADLDKSDLPACDLER-KYSDSIN 312          
The following BLAST results are available for this feature:
BLAST of Cyclin-dependent kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CDK16.722e-7241.81cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:... [more]
CDK13.889e-7141.14cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:... [more]
CDK31.198e-6940.49cyclin dependent kinase 3 [Source:HGNC Symbol;Acc:... [more]
CDK31.198e-6940.49cyclin dependent kinase 3 [Source:HGNC Symbol;Acc:... [more]
CDK26.528e-6640.70cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:... [more]
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BLAST of Cyclin-dependent kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cdk-14.781e-7238.92Cyclin-dependent kinase 1 [Source:UniProtKB/Swiss... [more]
cdk-14.781e-7238.92Cyclin-dependent kinase 1 [Source:UniProtKB/Swiss... [more]
cdk-21.386e-5536.42Cyclin-dependent kinase 2 [Source:UniProtKB/Swiss... [more]
cdk-51.939e-5234.16Cyclin-dependent-like kinase 5 [Source:UniProtKB/... [more]
cdk-11.21.221e-5135.24Cyclin-Dependent Kinase family [Source:UniProtKB/... [more]
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BLAST of Cyclin-dependent kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cdk13.003e-6640.00gene:FBgn0004106 transcript:FBtr0080051[more]
Cdk25.905e-6238.13gene:FBgn0004107 transcript:FBtr0083922[more]
Cdk25.905e-6238.13gene:FBgn0004107 transcript:FBtr0300447[more]
Cdk25.905e-6238.13gene:FBgn0004107 transcript:FBtr0083921[more]
Cdk51.832e-5536.84gene:FBgn0013762 transcript:FBtr0087350[more]
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BLAST of Cyclin-dependent kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cdk12.791e-7039.46cyclin-dependent kinase 1 [Source:ZFIN;Acc:ZDB-GEN... [more]
cdk12.791e-7039.46cyclin-dependent kinase 1 [Source:ZFIN;Acc:ZDB-GEN... [more]
cdk21.368e-6943.06cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GEN... [more]
cdk52.220e-5736.21cyclin-dependent kinase 5 [Source:ZFIN;Acc:ZDB-GEN... [more]
cdk41.369e-5137.76cyclin-dependent kinase 4 [Source:ZFIN;Acc:ZDB-GEN... [more]
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BLAST of Cyclin-dependent kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cfap653.695e-7442.81cilia and flagella associated protein 65 [Source:X... [more]
cfap653.834e-7342.47cilia and flagella associated protein 65 [Source:X... [more]
cfap655.790e-7342.61cilia and flagella associated protein 65 [Source:X... [more]
cdk25.428e-6941.34cyclin-dependent kinase 2 [Source:NCBI gene;Acc:49... [more]
cdk23.911e-6338.11cyclin-dependent kinase 2 [Source:NCBI gene;Acc:49... [more]
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BLAST of Cyclin-dependent kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cdk12.203e-7041.14cyclin-dependent kinase 1 [Source:MGI Symbol;Acc:M... [more]
Cdk12.203e-7041.14cyclin-dependent kinase 1 [Source:MGI Symbol;Acc:M... [more]
Cdk22.278e-6641.40cyclin-dependent kinase 2 [Source:MGI Symbol;Acc:M... [more]
Cdk31.039e-6238.89cyclin-dependent kinase 3 [Source:MGI Symbol;Acc:M... [more]
Cdk55.976e-5836.77cyclin-dependent kinase 5 [Source:MGI Symbol;Acc:M... [more]
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BLAST of Cyclin-dependent kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P35567|CDK1A_XENLA2.647e-7342.96Cyclin-dependent kinase 1-A OS=Xenopus laevis OX=8... [more]
sp|P13863|CDK1_CHICK8.838e-7342.05Cyclin-dependent kinase 1 OS=Gallus gallus OX=9031... [more]
sp|P06493|CDK1_HUMAN3.228e-7141.81Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 ... [more]
sp|P24033|CDK1B_XENLA4.467e-7140.73Cyclin-dependent kinase 1-B OS=Xenopus laevis OX=8... [more]
sp|A8XA58|CDK1_CAEBR4.571e-7139.74Cyclin-dependent kinase 1 OS=Caenorhabditis briggs... [more]
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BLAST of Cyclin-dependent kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
Q5DB606.610e-8342.22Cyclin-dependent kinase 1 isoform 2 OS=Schistosoma... [more]
A0A095BXJ31.561e-8244.21Cyclin-dependent kinase 1 OS=Schistosoma haematobi... [more]
G4VLX91.957e-8244.21Serine/threonine kinase OS=Schistosoma mansoni OX=... [more]
A0A183LHM52.203e-8244.21Protein kinase domain-containing protein OS=Schist... [more]
A0A183K4682.562e-8244.21Protein kinase domain-containing protein OS=Schist... [more]
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BLAST of Cyclin-dependent kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cdk15.358e-7039.39cyclin dependent kinase 1 [Source:NCBI gene;Acc:10... [more]
cdk15.358e-7039.39cyclin dependent kinase 1 [Source:NCBI gene;Acc:10... [more]
cdk21.160e-6742.01cyclin dependent kinase 2 [Source:NCBI gene;Acc:10... [more]
cdk11.765e-5837.87cyclin dependent kinase 1 [Source:NCBI gene;Acc:10... [more]
cdk54.661e-5736.77cyclin dependent kinase 5 [Source:NCBI gene;Acc:10... [more]
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BLAST of Cyclin-dependent kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cdk21.649e-6640.00cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GEN... [more]
cdk11.481e-6439.86cyclin-dependent kinase 1 [Source:ZFIN;Acc:ZDB-GEN... [more]
cdk22.298e-6239.44cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GEN... [more]
ENSPMAT00000008013.12.473e-5235.93pep scaffold:Pmarinus_7.0:GL478839:10839:40406:1 g... [more]
cdk48.807e-4735.29cyclin-dependent kinase 4 [Source:ZFIN;Acc:ZDB-GEN... [more]
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BLAST of Cyclin-dependent kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
CDC284.986e-5835.67Cyclin-dependent kinase (CDK) catalytic subunit; m... [more]
PHO852.606e-5032.67Cyclin-dependent kinase; has ten cyclin partners; ... [more]
CTK13.718e-4536.01Catalytic (alpha) subunit of C-terminal domain kin... [more]
FUS31.449e-3831.63Mitogen-activated serine/threonine protein kinase ... [more]
KIN282.493e-3728.92Serine/threonine protein kinase, subunit of transc... [more]
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BLAST of Cyclin-dependent kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO414031.951e-6840.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO436711.065e-6138.81Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO494201.303e-5736.17Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO408411.044e-5335.23Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO481171.846e-4834.60Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Cyclin-dependent kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cdk14.720e-7038.41cyclin dependent kinase 1 [Source:NCBI gene;Acc:10... [more]
cdk23.042e-6641.64cyclin dependent kinase 2 [Source:NCBI gene;Acc:10... [more]
cdk51.772e-5736.77cyclin dependent kinase 5 [Source:NCBI gene;Acc:10... [more]
cdk11b1.319e-5135.93cyclin-dependent kinase 11B [Source:NCBI gene;Acc:... [more]
cdk61.931e-5135.91cyclin dependent kinase 6 [Source:NCBI gene;Acc:10... [more]
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BLAST of Cyclin-dependent kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000023609.10.000e+0100.00SMESG000023609.1[more]
SMESG000023609.10.000e+099.43SMESG000023609.1[more]
SMESG000023590.10.000e+095.11SMESG000023590.1[more]
SMESG000052421.11.637e-7438.77SMESG000052421.1[more]
SMESG000052413.14.530e-6938.78SMESG000052413.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30024555 ID=SMED30024555|Name=Cyclin-dependent kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=1199bp
GTTTAAATAGATCTAAATTTATTATAAATTAGATTCTTTCTTATACTGAA
AGCGAATTGTATCATGAATACTCAAGAAATTGATATATTATTTACTGACA
TTCCTCATCAACTGTACCGCATTGGAGATTATGCTATACTAAGCAAACTC
GGAAGTTATGGCAGAGTTTATCTAGCTAAAAACAAGCAAAACAAATTTCT
TTATGCCCTTAAGAAGCTTAAAATTGATGAAGGTATTCCTACTACAACTT
TGAGAGAGATTAGTTTGTTAAAGATCTTACAACATCCAAACATTATCAAT
CTCCATCAAGTATTGGTATCAGATAAGCGAATTTATATGATTATGGAATA
CATGAAAATGAGTTTAAATCTATTTCTCAGAGATTTTGATGTTTCTTCTA
ATTTATTACAGAGTTTCATGTTTCAACTTCTACAAGCAACCGCATTTTGT
CATAACCGCCGAGTTCTGCATCGTGATATAAAATCCCAGAATATCCTAGT
TAATCATTCTATGAAGATTGTCAAATTATGTGATTTCGGTCTGTCTAGGA
AAATTGGGTTTTGTCCCGGTCGCCTTACTCCGACTGTGGTGACATTGTAT
TACCGCAGTCCCGAATTAATCCTAAACGAGGGAATTTATTTCTCCGGTGT
AGACATTTGGTCTTTAGGCTGCGTGTTCGTAGAAATGGTTTTAAAGCATC
CTCCATTTAGAGTTGATGGAGAAATACAATTATTCTTTAGTTGGTTCACT
CAATTAGGAGTTCCAAATGACGATGATATGCCTGGCGCAAAGGTTAAATT
TGAGTCCATGAATTTTCAAGAAAGCAAAAATTCATTTAACGCTATCAAGC
TCTTGAAAACAAAAGTGAATTCGAAATGCTTTGATCTTATAATGCAAATG
TTTATATATAATCCTCTGAAAAGAATAGGCGCATCTGCAGCATTGCTGCA
TGAATATTTTCACGATTTCGACAGATCAGTTGCTCCTGCTATCGGCGAGG
AAAATGTTGGATTTCCGGAAGAAATTAATGCCCCCAGAAAACCTCAAGTT
CTTTATTTAACTACGGATCATTTAGAAGGACTGAATGATCAAGGAAATAT
GGAAACTAAATAAAATCTGTATTTTTGTTTTCAAAAACAACAACGGCATT
TAATTAATAATCTGTACTTTATGGTAGAGCTTTTGTAATAAAGATTTTT
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protein sequence of SMED30024555-orf-1

>SMED30024555-orf-1 ID=SMED30024555-orf-1|Name=SMED30024555-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=350bp
MNTQEIDILFTDIPHQLYRIGDYAILSKLGSYGRVYLAKNKQNKFLYALK
KLKIDEGIPTTTLREISLLKILQHPNIINLHQVLVSDKRIYMIMEYMKMS
LNLFLRDFDVSSNLLQSFMFQLLQATAFCHNRRVLHRDIKSQNILVNHSM
KIVKLCDFGLSRKIGFCPGRLTPTVVTLYYRSPELILNEGIYFSGVDIWS
LGCVFVEMVLKHPPFRVDGEIQLFFSWFTQLGVPNDDDMPGAKVKFESMN
FQESKNSFNAIKLLKTKVNSKCFDLIMQMFIYNPLKRIGASAALLHEYFH
DFDRSVAPAIGEENVGFPEEINAPRKPQVLYLTTDHLEGLNDQGNMETK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000014zeta neoblast
PLANA:0000429neoblast
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR000719Prot_kinase_dom
IPR008271Ser/Thr_kinase_AS
IPR011009Kinase-like_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0004672protein kinase activity
GO:0005524ATP binding
GO:0000166nucleotide binding
GO:0004674protein serine/threonine kinase activity
GO:0016301kinase activity
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0016310phosphorylation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 23..299
e-value: 2.3E-76
score: 269.7
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 30..299
e-value: 6.7E-59
score: 199.4
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 21..299
score: 39.75
NoneNo IPR availableGENE3DG3DSA:3.30.200.20coord: 16..98
e-value: 1.6E-22
score: 81.1
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 106..320
e-value: 1.1E-50
score: 174.5
NoneNo IPR availablePANTHERPTHR24056:SF415coord: 28..302
NoneNo IPR availablePANTHERPTHR24056CELL DIVISION PROTEIN KINASEcoord: 28..302
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 134..146
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 17..303