General transcription factor iih subunit 1

Overview
NameGeneral transcription factor iih subunit 1
Smed IDSMED30024480
Length (bp)1779
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of General transcription factor iih subunit 1 (SMED30024480) t-SNE clustered cells

Violin plots show distribution of expression levels for General transcription factor iih subunit 1 (SMED30024480) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of General transcription factor iih subunit 1 (SMED30024480) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for General transcription factor iih subunit 1 (SMED30024480) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30024480

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30024480SMESG000055374.1 SmedASXL_007714SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30024480SMESG000055374.1 SmedASXL_007714SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Human
Match: GTF2H1 (general transcription factor IIH subunit 1 [Source:HGNC Symbol;Acc:HGNC:4655])

HSP 1 Score: 233.032 bits (593), Expect = 1.859e-68
Identity = 162/551 (29.40%), Postives = 273/551 (49.55%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFW-QRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDL-SNDKFGSCAYYDIQQIEKEAQRLKKESLI---LIQDKT--EDVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEK-STFDRLEGVKFNTDKVSQY------INRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYILT 1655
            ++ S+E+++ ++  V  KK +G LYLM ER+AW     D F IS  Y +I+ Q+ISP+ K K+QLQL++H+G +  FHF      S  V +R+ VK  LQ  +P+FK KA  ELE K ++ + +P +  LY++LV ++ +  EEFW  R   N +  SS + +   + GI +  LA   PQ DG +  + NL+  ++E IF  YPAVK K+ + VP+ M+E+EFW +FFQSHYFHR + +  S D F  CA  D + ++       K  L+    ++DK   E  G   VP  +    NS + K +S+  +++RFN  S ++L     K  ++    S+  ++D  +        + +    +E    E     + ++ +  N  K  +Y      I  +  +   ++ +   + R+ ++ +  +  + L+    +  +T   P   LM                           QQ  N   +P ++  ++K LY    EL RHFW CFPV      EK+ +M   +++F++ K+  F ++    Y+ T
Sbjct:    1 MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGKAKIQLQLVLHAGDTTNFHF---SNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQ-DVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSAS----NSKSIKENSNAAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEYEDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQVLSSSAASSTITALSPGGALMQGGT-----------------------QQAINQ-MVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLST 519
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Human
Match: GTF2H1 (general transcription factor IIH subunit 1 [Source:HGNC Symbol;Acc:HGNC:4655])

HSP 1 Score: 233.032 bits (593), Expect = 1.859e-68
Identity = 162/551 (29.40%), Postives = 273/551 (49.55%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFW-QRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDL-SNDKFGSCAYYDIQQIEKEAQRLKKESLI---LIQDKT--EDVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEK-STFDRLEGVKFNTDKVSQY------INRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYILT 1655
            ++ S+E+++ ++  V  KK +G LYLM ER+AW     D F IS  Y +I+ Q+ISP+ K K+QLQL++H+G +  FHF      S  V +R+ VK  LQ  +P+FK KA  ELE K ++ + +P +  LY++LV ++ +  EEFW  R   N +  SS + +   + GI +  LA   PQ DG +  + NL+  ++E IF  YPAVK K+ + VP+ M+E+EFW +FFQSHYFHR + +  S D F  CA  D + ++       K  L+    ++DK   E  G   VP  +    NS + K +S+  +++RFN  S ++L     K  ++    S+  ++D  +        + +    +E    E     + ++ +  N  K  +Y      I  +  +   ++ +   + R+ ++ +  +  + L+    +  +T   P   LM                           QQ  N   +P ++  ++K LY    EL RHFW CFPV      EK+ +M   +++F++ K+  F ++    Y+ T
Sbjct:    1 MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGKAKIQLQLVLHAGDTTNFHF---SNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQ-DVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSAS----NSKSIKENSNAAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEYEDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQVLSSSAASSTITALSPGGALMQGGT-----------------------QQAINQ-MVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLST 519
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Human
Match: GTF2H1 (general transcription factor IIH subunit 1 [Source:HGNC Symbol;Acc:HGNC:4655])

HSP 1 Score: 233.032 bits (593), Expect = 1.859e-68
Identity = 162/551 (29.40%), Postives = 273/551 (49.55%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFW-QRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDL-SNDKFGSCAYYDIQQIEKEAQRLKKESLI---LIQDKT--EDVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEK-STFDRLEGVKFNTDKVSQY------INRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYILT 1655
            ++ S+E+++ ++  V  KK +G LYLM ER+AW     D F IS  Y +I+ Q+ISP+ K K+QLQL++H+G +  FHF      S  V +R+ VK  LQ  +P+FK KA  ELE K ++ + +P +  LY++LV ++ +  EEFW  R   N +  SS + +   + GI +  LA   PQ DG +  + NL+  ++E IF  YPAVK K+ + VP+ M+E+EFW +FFQSHYFHR + +  S D F  CA  D + ++       K  L+    ++DK   E  G   VP  +    NS + K +S+  +++RFN  S ++L     K  ++    S+  ++D  +        + +    +E    E     + ++ +  N  K  +Y      I  +  +   ++ +   + R+ ++ +  +  + L+    +  +T   P   LM                           QQ  N   +P ++  ++K LY    EL RHFW CFPV      EK+ +M   +++F++ K+  F ++    Y+ T
Sbjct:    1 MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGKAKIQLQLVLHAGDTTNFHF---SNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQ-DVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSAS----NSKSIKENSNAAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEYEDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQVLSSSAASSTITALSPGGALMQGGT-----------------------QQAINQ-MVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLST 519
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Human
Match: GTF2H1 (general transcription factor IIH subunit 1 [Source:HGNC Symbol;Acc:HGNC:4655])

HSP 1 Score: 233.032 bits (593), Expect = 1.859e-68
Identity = 162/551 (29.40%), Postives = 273/551 (49.55%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFW-QRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDL-SNDKFGSCAYYDIQQIEKEAQRLKKESLI---LIQDKT--EDVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEK-STFDRLEGVKFNTDKVSQY------INRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYILT 1655
            ++ S+E+++ ++  V  KK +G LYLM ER+AW     D F IS  Y +I+ Q+ISP+ K K+QLQL++H+G +  FHF      S  V +R+ VK  LQ  +P+FK KA  ELE K ++ + +P +  LY++LV ++ +  EEFW  R   N +  SS + +   + GI +  LA   PQ DG +  + NL+  ++E IF  YPAVK K+ + VP+ M+E+EFW +FFQSHYFHR + +  S D F  CA  D + ++       K  L+    ++DK   E  G   VP  +    NS + K +S+  +++RFN  S ++L     K  ++    S+  ++D  +        + +    +E    E     + ++ +  N  K  +Y      I  +  +   ++ +   + R+ ++ +  +  + L+    +  +T   P   LM                           QQ  N   +P ++  ++K LY    EL RHFW CFPV      EK+ +M   +++F++ K+  F ++    Y+ T
Sbjct:    1 MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGKAKIQLQLVLHAGDTTNFHF---SNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQ-DVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSAS----NSKSIKENSNAAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEYEDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQVLSSSAASSTITALSPGGALMQGGT-----------------------QQAINQ-MVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLST 519
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Human
Match: GTF2H1 (general transcription factor IIH subunit 1 [Source:HGNC Symbol;Acc:HGNC:4655])

HSP 1 Score: 132.88 bits (333), Expect = 5.584e-33
Identity = 111/432 (25.69%), Postives = 198/432 (45.83%), Query Frame = 3 
Query:  411 LCENNPQILDLYRELVTNKYMCKEEFW-QRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDL-SNDKFGSCAYYDIQQIEKEAQRLKKESLI---LIQDKT--EDVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEK-STFDRLEGVKFNTDKVSQY------INRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYILT 1655
            + + +P +  LY++LV ++ +  EEFW  R   N +  SS + +   + GI +  LA   PQ DG +  + NL+  ++E IF  YPAVK K+ + VP+ M+E+EFW +FFQSHYFHR + +  S D F  CA  D + ++       K  L+    ++DK   E  G   VP  +    NS + K +S+  +++RFN  S ++L     K  ++    S+  ++D  +        + +    +E    E     + ++ +  N  K  +Y      I  +  +   ++ +   + R+ ++ +  +  + L+    +  +T   P   LM                           QQ  N   +P ++  ++K LY    EL RHFW CFPV      EK+ +M   +++F++ K+  F ++    Y+ T
Sbjct:    1 MLQEDPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQ-DVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSAS----NSKSIKENSNAAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEYEDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQVLSSSAASSTITALSPGGALMQGGT-----------------------QQAINQ-MVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLST 403
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Celegans
Match: gtf-2H1 (General Transcription Factor homolog [Source:UniProtKB/TrEMBL;Acc:O44499])

HSP 1 Score: 170.244 bits (430), Expect = 5.746e-46
Identity = 167/581 (28.74%), Postives = 271/581 (46.64%), Query Frame = 3 
Query:   87 IDHVSYKKTE------GKLYLMTERLAWMTNTS-DVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQ-VSDRNNVKISLQYFIPRFKEKA------------QSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLATPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDLSN--DKFGSCAYYDIQQIEK-EAQRLKKESLILIQDKTEDVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEKSTFDRLEGVKFNTDKVSQYIN--RISSSNVANVTSQSTADRKRLKQ-----FQDEQLRRLAGLKQNLALTRCRPLVNL-MSSSVATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYILTGSMDSKPIDHLCKMTDRVNEAFERY 1730
            +DHV Y+K        G+L L T+ + W  N S +VF     +  I  QR+SP  K KVQLQL++ +    TF F++P    +  V +R+ VK +LQ  + + + +             Q EL+ K+K+ + +  +  LY+ LV  K +  ++FW    S+  Q+  V+E  +   GI    LA   Q++G +  + NL+ ++++ I++ YPAV++K+ +LVP+EMSEE FW KFFQSHYFHR +  L N  D F  C   D +++ K  A++++++   L     E + +  + D   K   S++Q+ S+   L++R N  S  IL       TS R+ ++      + N+K+         +   +R V E  T  RLE     T +    +   RISSS  A+    S  D  R K      FQ+  +  +  L +N  L   + +    M  ++ TD            +  V       ++AG L    +RD+    R   E+ R FW+ FP  D A  EKL+RM   + K+R               I    +  + + H  +M D   + FE Y
Sbjct:   11 VDHVKYRKAGDGKSPIGRLALFTDFIEWRDNASPEVFTCK--FIRINGQRVSPPHKSKVQLQLILKNEDQATFVFLNPSASKEDLVKERDAVKEALQSALVKHRHRVNELAKSVESQSKQVELQAKQKILQEDRNLEKLYQNLVATKLITPDDFW----SDYYQKEGVSEDKI---GINGAFLANIVQQEGTNGVRLNLNPEIIQAIYSTYPAVQKKNLELVPHEMSEENFWKKFFQSHYFHREREVLPNPKDPFAECVRDDEEEMTKMTAEKIQRKRFDL-----EHIDDNGLRDFIHK---SESQQKSAKTTLIKRCNYLSEKILA------TSWRSGEAAPTTSAAANQKK--------GFGVLDRLVAETET--RLESEDLATKEAEDEVQIVRISSSAKASQAKYSKPDMTRYKALVTDYFQNSSVEDI--LHRNEMLLDQQEMETWEMEEAMETD------------NNEVPPPENWCQSAGDLAK--VRDVHSAVR---EICRQFWKSFPPIDKASEEKLNRMAGTLSKYRDD-------------IRNSDISKENLTHCIQMIDLAVDKFEAY 526
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Fly
Match: Tfb1 (gene:FBgn0033929 transcript:FBtr0305616)

HSP 1 Score: 242.276 bits (617), Expect = 7.185e-72
Identity = 179/573 (31.24%), Postives = 287/573 (50.09%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLATPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFK-SDLSNDKFGSCAYYDIQQIEKEAQRLKKESLILIQDKTEDVGEFCVPDNTG-KSVNSDTQKSSSS----EELLRRFNRQSFLILKTMKS--------KNTSKRAND-------------------------SDCVDLDSG-NEKRRLIDSSSEMYSEEERFVLEKSTFDRLEGVK---FNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRL-AGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQG---RNAGKLPP-EMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGF 1622
            ++ S+ED++  +  V YKK +G LY+M ER+AWM    D   +S  Y +I+ Q+ISP+ K KVQLQ+++H G++ TFHF++  G++  ++DR+ VK  LQ  +P FK K   +LE+K ++   NP +L LY++LV  K +  +EFW     + + +       +   G  ++L    PQ DG +  + NL+  ++  IF  YPAVK+KH + VP +MSE EFW KFFQSHYFHR + +  + D F  C   D Q ++   Q+   + L+ ++ K ED     VP   G  SV  D    +S     + +++RFN+ S ++LKT  +         N +  AN                          SD VD D   ++K+RL++     Y +    +LE       E  K   F   KV +Y+N      V N    +  D   L++ Q + +R   + L +N+  T        + S  A + L          +++    + +G   ++AG+L P +  R+++ LY   SEL +HFW CFP T      KL RM E +++F++ K+  F
Sbjct:    1 MTTSSEDVLLQMGEVRYKKGDGTLYVMNERVAWMAEHRDTVTVSHRYADIKTQKISPEGKPKVQLQVVLHDGNTSTFHFVNRQGQAAMLADRDKVKELLQQLLPNFKRKVDKDLEDKNRILVENPNLLQLYKDLVITKVLTSDEFWATHAKDHALKKMGRSQEIGVSG--AFLADIKPQTDGCNGLKYNLTSDVIHCIFKTYPAVKRKHFENVPAKMSEAEFWTKFFQSHYFHRDRLTAGTKDIFTECGKIDDQALKAAVQQGAGDPLLDLK-KFED-----VPLEEGFGSVAGDRNVVNSGNIVHQNMIKRFNQHSIMVLKTCANVTSAPSTMTNGTNNANGPVSQSAYTNGMNGKGQATATATKSSSDQVDKDEPQSKKQRLMEKIH--YVDLGDPILEGDDSANGEKAKSKHFELSKVERYLN----GPVQNSMYDNHNDPMSLEEVQYKLVRNSESWLNRNVQRT-------FICSKAAVNAL---------GELSPGGSMMRGFQEQSAGQLVPNDFQRELRHLYLSLSELLKHFWSCFPPTSEELETKLQRMHETLQRFKMAKLVPF 543
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Fly
Match: Tfb1 (gene:FBgn0033929 transcript:FBtr0087550)

HSP 1 Score: 242.276 bits (617), Expect = 7.185e-72
Identity = 179/573 (31.24%), Postives = 287/573 (50.09%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLATPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFK-SDLSNDKFGSCAYYDIQQIEKEAQRLKKESLILIQDKTEDVGEFCVPDNTG-KSVNSDTQKSSSS----EELLRRFNRQSFLILKTMKS--------KNTSKRAND-------------------------SDCVDLDSG-NEKRRLIDSSSEMYSEEERFVLEKSTFDRLEGVK---FNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRL-AGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQG---RNAGKLPP-EMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGF 1622
            ++ S+ED++  +  V YKK +G LY+M ER+AWM    D   +S  Y +I+ Q+ISP+ K KVQLQ+++H G++ TFHF++  G++  ++DR+ VK  LQ  +P FK K   +LE+K ++   NP +L LY++LV  K +  +EFW     + + +       +   G  ++L    PQ DG +  + NL+  ++  IF  YPAVK+KH + VP +MSE EFW KFFQSHYFHR + +  + D F  C   D Q ++   Q+   + L+ ++ K ED     VP   G  SV  D    +S     + +++RFN+ S ++LKT  +         N +  AN                          SD VD D   ++K+RL++     Y +    +LE       E  K   F   KV +Y+N      V N    +  D   L++ Q + +R   + L +N+  T        + S  A + L          +++    + +G   ++AG+L P +  R+++ LY   SEL +HFW CFP T      KL RM E +++F++ K+  F
Sbjct:    1 MTTSSEDVLLQMGEVRYKKGDGTLYVMNERVAWMAEHRDTVTVSHRYADIKTQKISPEGKPKVQLQVVLHDGNTSTFHFVNRQGQAAMLADRDKVKELLQQLLPNFKRKVDKDLEDKNRILVENPNLLQLYKDLVITKVLTSDEFWATHAKDHALKKMGRSQEIGVSG--AFLADIKPQTDGCNGLKYNLTSDVIHCIFKTYPAVKRKHFENVPAKMSEAEFWTKFFQSHYFHRDRLTAGTKDIFTECGKIDDQALKAAVQQGAGDPLLDLK-KFED-----VPLEEGFGSVAGDRNVVNSGNIVHQNMIKRFNQHSIMVLKTCANVTSAPSTMTNGTNNANGPVSQSAYTNGMNGKGQATATATKSSSDQVDKDEPQSKKQRLMEKIH--YVDLGDPILEGDDSANGEKAKSKHFELSKVERYLN----GPVQNSMYDNHNDPMSLEEVQYKLVRNSESWLNRNVQRT-------FICSKAAVNAL---------GELSPGGSMMRGFQEQSAGQLVPNDFQRELRHLYLSLSELLKHFWSCFPPTSEELETKLQRMHETLQRFKMAKLVPF 543
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Fly
Match: Tfb1 (gene:FBgn0033929 transcript:FBtr0087548)

HSP 1 Score: 242.276 bits (617), Expect = 7.185e-72
Identity = 179/573 (31.24%), Postives = 287/573 (50.09%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLATPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFK-SDLSNDKFGSCAYYDIQQIEKEAQRLKKESLILIQDKTEDVGEFCVPDNTG-KSVNSDTQKSSSS----EELLRRFNRQSFLILKTMKS--------KNTSKRAND-------------------------SDCVDLDSG-NEKRRLIDSSSEMYSEEERFVLEKSTFDRLEGVK---FNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRL-AGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQG---RNAGKLPP-EMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGF 1622
            ++ S+ED++  +  V YKK +G LY+M ER+AWM    D   +S  Y +I+ Q+ISP+ K KVQLQ+++H G++ TFHF++  G++  ++DR+ VK  LQ  +P FK K   +LE+K ++   NP +L LY++LV  K +  +EFW     + + +       +   G  ++L    PQ DG +  + NL+  ++  IF  YPAVK+KH + VP +MSE EFW KFFQSHYFHR + +  + D F  C   D Q ++   Q+   + L+ ++ K ED     VP   G  SV  D    +S     + +++RFN+ S ++LKT  +         N +  AN                          SD VD D   ++K+RL++     Y +    +LE       E  K   F   KV +Y+N      V N    +  D   L++ Q + +R   + L +N+  T        + S  A + L          +++    + +G   ++AG+L P +  R+++ LY   SEL +HFW CFP T      KL RM E +++F++ K+  F
Sbjct:    1 MTTSSEDVLLQMGEVRYKKGDGTLYVMNERVAWMAEHRDTVTVSHRYADIKTQKISPEGKPKVQLQVVLHDGNTSTFHFVNRQGQAAMLADRDKVKELLQQLLPNFKRKVDKDLEDKNRILVENPNLLQLYKDLVITKVLTSDEFWATHAKDHALKKMGRSQEIGVSG--AFLADIKPQTDGCNGLKYNLTSDVIHCIFKTYPAVKRKHFENVPAKMSEAEFWTKFFQSHYFHRDRLTAGTKDIFTECGKIDDQALKAAVQQGAGDPLLDLK-KFED-----VPLEEGFGSVAGDRNVVNSGNIVHQNMIKRFNQHSIMVLKTCANVTSAPSTMTNGTNNANGPVSQSAYTNGMNGKGQATATATKSSSDQVDKDEPQSKKQRLMEKIH--YVDLGDPILEGDDSANGEKAKSKHFELSKVERYLN----GPVQNSMYDNHNDPMSLEEVQYKLVRNSESWLNRNVQRT-------FICSKAAVNAL---------GELSPGGSMMRGFQEQSAGQLVPNDFQRELRHLYLSLSELLKHFWSCFPPTSEELETKLQRMHETLQRFKMAKLVPF 543
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Fly
Match: Tfb1 (gene:FBgn0033929 transcript:FBtr0087549)

HSP 1 Score: 242.276 bits (617), Expect = 7.185e-72
Identity = 179/573 (31.24%), Postives = 287/573 (50.09%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLATPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFK-SDLSNDKFGSCAYYDIQQIEKEAQRLKKESLILIQDKTEDVGEFCVPDNTG-KSVNSDTQKSSSS----EELLRRFNRQSFLILKTMKS--------KNTSKRAND-------------------------SDCVDLDSG-NEKRRLIDSSSEMYSEEERFVLEKSTFDRLEGVK---FNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRL-AGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQG---RNAGKLPP-EMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGF 1622
            ++ S+ED++  +  V YKK +G LY+M ER+AWM    D   +S  Y +I+ Q+ISP+ K KVQLQ+++H G++ TFHF++  G++  ++DR+ VK  LQ  +P FK K   +LE+K ++   NP +L LY++LV  K +  +EFW     + + +       +   G  ++L    PQ DG +  + NL+  ++  IF  YPAVK+KH + VP +MSE EFW KFFQSHYFHR + +  + D F  C   D Q ++   Q+   + L+ ++ K ED     VP   G  SV  D    +S     + +++RFN+ S ++LKT  +         N +  AN                          SD VD D   ++K+RL++     Y +    +LE       E  K   F   KV +Y+N      V N    +  D   L++ Q + +R   + L +N+  T        + S  A + L          +++    + +G   ++AG+L P +  R+++ LY   SEL +HFW CFP T      KL RM E +++F++ K+  F
Sbjct:    1 MTTSSEDVLLQMGEVRYKKGDGTLYVMNERVAWMAEHRDTVTVSHRYADIKTQKISPEGKPKVQLQVVLHDGNTSTFHFVNRQGQAAMLADRDKVKELLQQLLPNFKRKVDKDLEDKNRILVENPNLLQLYKDLVITKVLTSDEFWATHAKDHALKKMGRSQEIGVSG--AFLADIKPQTDGCNGLKYNLTSDVIHCIFKTYPAVKRKHFENVPAKMSEAEFWTKFFQSHYFHRDRLTAGTKDIFTECGKIDDQALKAAVQQGAGDPLLDLK-KFED-----VPLEEGFGSVAGDRNVVNSGNIVHQNMIKRFNQHSIMVLKTCANVTSAPSTMTNGTNNANGPVSQSAYTNGMNGKGQATATATKSSSDQVDKDEPQSKKQRLMEKIH--YVDLGDPILEGDDSANGEKAKSKHFELSKVERYLN----GPVQNSMYDNHNDPMSLEEVQYKLVRNSESWLNRNVQRT-------FICSKAAVNAL---------GELSPGGSMMRGFQEQSAGQLVPNDFQRELRHLYLSLSELLKHFWSCFPPTSEELETKLQRMHETLQRFKMAKLVPF 543
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Zebrafish
Match: gtf2h1 (general transcription factor IIH, polypeptide 1 [Source:ZFIN;Acc:ZDB-GENE-040912-164])

HSP 1 Score: 220.32 bits (560), Expect = 6.851e-64
Identity = 162/566 (28.62%), Postives = 279/566 (49.29%), Query Frame = 3 
Query:   66 TEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDLS-NDKFGSCAYYDIQQIEKEAQRLKKES---LILIQDKTEDVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKT--MKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEKSTFDRLEG------VKFNTDKVSQY------INRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSS--------VATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYI---LTGSMD 1667
            +E+++ ++  V  +K +G LYLM ER+AW     D F +S  Y +IR Q+ISPD K K+QLQL++H+G + TFHF +    S  + DR   K  LQ  +P+FK+KA  ELE K ++ + +P +  LY++LV ++ +  EEFW    S  S   S +  ++   GI +  LA   PQ DG +  + NL+  ++E IF  YP VKQK+ + VP+ M+E+EFW +FFQSHYFHR + +    D F  CA  D + ++    +  K     L+ ++DKT D G          +  + T + +S+  +++RFN  S ++L     K++  S +A+++   D   GN +    DS       ++  + E   +D L+       +  N  K  +Y      +     S   ++ +  +  +  ++ ++ +  + ++    + A++   P   LM S+        V  DV +++ HL++               AG+L                   RHFW CFPV      EK+ +M   +++F++ K+  F ++    Y+   LTG ++
Sbjct:    5 SEEVLLVVKRVRQRKQDGTLYLMAERIAWGPEGKDRFTVSHLYADIRCQKISPDGKAKIQLQLVLHTGENTTFHFAN---ESTALKDREAAKELLQQLLPKFKKKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWANRMSLNSVDHSPSSNNVQEVGISAAFLADIRPQTDGCNGLRYNLTSDIIESIFRTYPTVKQKYAENVPHNMTEKEFWTRFFQSHYFHRDRINTGQQDIFSECAKQDEKGLKSMVTQGVKNPMVDLLALEDKTLDEGYGTAAAPPASNTANKTLRENSNSAIIKRFNHHSAMVLAAGLRKAEAPSDQASETSSTD---GNSR----DSDFFQPPLKKVKLQEAIEYDDLQNDSGRKTIALNLKKSDRYAHGPVPLQSQHYSTSQDIINSISIIQHEMRSYKPQLTQVMSSSAASSAISALSPGGVLMQSAGQQTIHQLVPADVQSELKHLYT--------------AAGEL------------------LRHFWSCFPVNTPFLEEKVLKMKSNLERFQVTKLRPFQEKIQRQYLSTNLTGHLE 528
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Xenopus
Match: rnf168 (ring finger protein 168, E3 ubiquitin protein ligase [Source:Xenbase;Acc:XB-GENE-5765249])

HSP 1 Score: 235.728 bits (600), Expect = 1.964e-69
Identity = 175/561 (31.19%), Postives = 282/561 (50.27%), Query Frame = 3 
Query:   48 SNVSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDL-SNDKFGSCAYYDIQQIEKEAQRLKKES---LILIQDKTEDVGEFCVPDNTGKSVNSDTQ-----KSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEKSTFDRLEGVK---FNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVA---TDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYI---LTGSMD 1667
            S+++ S+E+++ ++  V +KK +G LYLM ER+AW     D F IS  Y +I+ Q+ISPD K KVQLQL++H G +  FHF      +  + +R+ VK  LQ  +P+FK KA  ELE K ++ + +P +  LY++LV ++ +  EEFW    S  S  SSV   S  + GI +  LA   PQ DG +  + NL+  ++E IF  YPAVK K+ + VP+ M+E++FW +FFQSHYFHR + +  + D F  CA  D + ++    +  K     L+ ++DK       C+ +  G S    T      K +S+  +++RFN  S ++L     K+ ++    S+    D  +          +    +E   +E    D+  G+K    N  K  +Y +  +      + SQ  A  + +       L  +  +KQ +     R L  ++SS  A   T  LT  G L       +    QQ  N   +P ++  ++K LY    EL RHFW CFPV      EK+ +M   +++F++ K+  F ++    Y+   LTG ++
Sbjct:    8 SDMATSSEEVLLIVKKVRHKKQDGALYLMAERVAWAPEGKDRFTISHMYADIKCQKISPDGKAKVQLQLVLHVGETTNFHF---SNDATAIKERDAVKELLQQLLPKFKRKANKELEEKNRMLKEDPVLFQLYKDLVVSQVISAEEFWANRLSLNSLDSSVLA-SKQDVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKLKYAENVPHNMTEKDFWKQFFQSHYFHRDRLNTGAKDLFAECAKMDERGLKSMVSQGVKNPMLDLMALEDK-------CLEEGYGISSAPSTSSTKSIKENSNAAIIKRFNHHSAMVLAAGLRKDEAQSDQCSETSSTDGNSRDSDFFLPPVKKVKLQE--AIEYEDLDQSNGMKPLVLNLKKSDRYYHGPTP-----IQSQQYASSQDI-------LSSIHSIKQQMENYTPR-LTQVLSSGAASSTTAALTPGGAL-------MQGVTQQAINQ-LVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVMKMKSNLERFQVTKLRPFQEKLRKQYLGTNLTGHLE 534
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Xenopus
Match: rnf168 (ring finger protein 168, E3 ubiquitin protein ligase [Source:Xenbase;Acc:XB-GENE-5765249])

HSP 1 Score: 233.802 bits (595), Expect = 9.883e-69
Identity = 174/560 (31.07%), Postives = 281/560 (50.18%), Query Frame = 3 
Query:   51 NVSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDL-SNDKFGSCAYYDIQQIEKEAQRLKKES---LILIQDKTEDVGEFCVPDNTGKSVNSDTQKSSSSEE-----LLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEKSTFDRLEGVK---FNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVA---TDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYI---LTGSMD 1667
            +++ S+E+++ ++  V +KK +G LYLM ER+AW     D F IS  Y +I+ Q+ISPD K KVQLQL++H G +  FHF      +  + +R+ VK  LQ  +P+FK KA  ELE K ++ + +P +  LY++LV ++ +  EEFW    S  S  SSV   S  + GI +  LA   PQ DG +  + NL+  ++E IF  YPAVK K+ + VP+ M+E++FW +FFQSHYFHR + +  + D F  CA  D + ++    +  K     L+ ++DK       C+ +  G S    T  + S +E     +++RFN  S ++L     K+ ++    S+    D  +          +    +E   +E    D+  G+K    N  K  +Y +  +      + SQ  A  + +       L  +  +KQ +     R L  ++SS  A   T  LT  G L       +    QQ  N   +P ++  ++K LY    EL RHFW CFPV      EK+ +M   +++F++ K+  F ++    Y+   LTG ++
Sbjct:    5 DMATSSEEVLLIVKKVRHKKQDGALYLMAERVAWAPEGKDRFTISHMYADIKCQKISPDGKAKVQLQLVLHVGETTNFHF---SNDATAIKERDAVKELLQQLLPKFKRKANKELEEKNRMLKEDPVLFQLYKDLVVSQVISAEEFWANRLSLNSLDSSVLA-SKQDVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKLKYAENVPHNMTEKDFWKQFFQSHYFHRDRLNTGAKDLFAECAKMDERGLKSMVSQGVKNPMLDLMALEDK-------CLEEGYGISSAPSTSSTKSIKENSNAAIIKRFNHHSAMVLAAGLRKDEAQSDQCSETSSTDGNSRDSDFFLPPVKKVKLQE--AIEYEDLDQSNGMKPLVLNLKKSDRYYHGPTP-----IQSQQYASSQDI-------LSSIHSIKQQMENYTPR-LTQVLSSGAASSTTAALTPGGAL-------MQGVTQQAINQ-LVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVMKMKSNLERFQVTKLRPFQEKLRKQYLGTNLTGHLE 530
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Xenopus
Match: rnf168 (ring finger protein 168, E3 ubiquitin protein ligase [Source:Xenbase;Acc:XB-GENE-5765249])

HSP 1 Score: 232.261 bits (591), Expect = 4.214e-68
Identity = 177/573 (30.89%), Postives = 284/573 (49.56%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDL-SNDKFGSCAYYDIQQIEKEAQRLKKES---LILIQDKTEDVGEFCVPDNTGKSVNSDTQ-----KSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEKSTFDRLEGVK---FNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVA---TDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYILTG--SMDSK-PIDHLCKMTDRV 1709
            ++ S+E+++ ++  V +KK +G LYLM ER+AW     D F IS  Y +I+ Q+ISPD K KVQLQL++H G +  FHF      +  + +R+ VK  LQ  +P+FK KA  ELE K ++ + +P +  LY++LV ++ +  EEFW    S  S  SSV   S  + GI +  LA   PQ DG +  + NL+  ++E IF  YPAVK K+ + VP+ M+E++FW +FFQSHYFHR + +  + D F  CA  D + ++    +  K     L+ ++DK       C+ +  G S    T      K +S+  +++RFN  S ++L     K+ ++    S+    D  +          +    +E   +E    D+  G+K    N  K  +Y +  +      + SQ  A  + +       L  +  +KQ +     R L  ++SS  A   T  LT  G L       +    QQ  N   +P ++  ++K LY    EL RHFW CFPV      EK+ +M   +++F++ K+  F ++    Y+ T   +M  + P+   C    RV
Sbjct:    1 MATSSEEVLLIVKKVRHKKQDGALYLMAERVAWAPEGKDRFTISHMYADIKCQKISPDGKAKVQLQLVLHVGETTNFHF---SNDATAIKERDAVKELLQQLLPKFKRKANKELEEKNRMLKEDPVLFQLYKDLVVSQVISAEEFWANRLSLNSLDSSVLA-SKQDVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKLKYAENVPHNMTEKDFWKQFFQSHYFHRDRLNTGAKDLFAECAKMDERGLKSMVSQGVKNPMLDLMALEDK-------CLEEGYGISSAPSTSSTKSIKENSNAAIIKRFNHHSAMVLAAGLRKDEAQSDQCSETSSTDGNSRDSDFFLPPVKKVKLQE--AIEYEDLDQSNGMKPLVLNLKKSDRYYHGPTP-----IQSQQYASSQDI-------LSSIHSIKQQMENYTPR-LTQVLSSGAASSTTAALTPGGAL-------MQGVTQQAINQ-LVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVMKMKSNLERFQVTKLRPFQEKLRKQYLGTNVRAMGGRFPVFTFCIWLLRV 539
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Xenopus
Match: rnf168 (ring finger protein 168, E3 ubiquitin protein ligase [Source:Xenbase;Acc:XB-GENE-5765249])

HSP 1 Score: 231.106 bits (588), Expect = 8.680e-68
Identity = 173/559 (30.95%), Postives = 278/559 (49.73%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDL-SNDKFGSCAYYDIQQIEKEAQRLKKES---LILIQDKTEDVGEFCVPDNTGKSVNSDTQ-----KSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEKSTFDRLEGVK---FNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVA---TDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYI---LTGSMD 1667
            ++ S+E+++ ++  V +KK +G LYLM ER+AW     D F IS  Y +I+ Q+ISPD K KVQLQL++H G +  FHF      +  + +R+ VK  LQ  +P+FK KA  ELE K ++ + +P +  LY++LV ++ +  EEFW    S  S  SSV   S  + GI +  LA   PQ DG +  + NL+  ++E IF  YPAVK K+ + VP+ M+E++FW +FFQSHYFHR + +  + D F  CA  D + ++    +  K     L+ ++DK       C+ +  G S    T      K +S+  +++RFN  S ++L     K+ ++    S+    D  +          +    +E   +E    D+  G+K    N  K  +Y +         + SQ  A  + +       L  +  +KQ +     R L  ++SS  A   T  LT  G L       +    QQ      +P ++  ++K LY    EL RHFW CFPV      EK+ +M   +++F++ K+  F ++    Y+   LTG ++
Sbjct:    1 MATSSEEVLLIVKKVRHKKQDGALYLMAERVAWAPEGKDRFTISHMYADIKCQKISPDGKAKVQLQLVLHVGETTNFHF---SNDATAIKERDAVKELLQQLLPKFKRKANKELEEKNRMLKEDPVLFQLYKDLVVSQVISAEEFWANRLSLNSLDSSVLA-SKQDVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKLKYAENVPHNMTEKDFWKQFFQSHYFHRDRLNTGAKDLFAECAKMDERGLKSMVSQGVKNPMLDLMALEDK-------CLEEGYGISSAPSTSSTKSIKENSNAAIIKRFNHHSAMVLAAGLRKDEAQSDQCSETSSTDGNSRDSDFFLPPVKKVKLQE--AIEYEDLDQSNGMKPLVLNLKKSDRYYH-----GPTPIQSQQYASSQDI-------LSSIHSIKQQMENYTPR-LTQVLSSGAASSTTAALTPGGAL-------MQGVTQQSWQL--VPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVMKMKSNLERFQVTKLRPFQEKLRKQYLGTNLTGHLE 524
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Xenopus
Match: rnf168 (ring finger protein 168, E3 ubiquitin protein ligase [Source:Xenbase;Acc:XB-GENE-5765249])

HSP 1 Score: 224.942 bits (572), Expect = 8.884e-66
Identity = 168/530 (31.70%), Postives = 263/530 (49.62%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDL-SNDKFGSCAYYDIQQIEKEAQRLKKES---LILIQDKTEDVGEFCVPDNTGKSVNSDTQ-----KSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEKSTFDRLEGVK---FNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVA---TDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAI 1589
            ++ S+E+++ ++  V +KK +G LYLM ER+AW     D F IS  Y +I+ Q+ISPD K KVQLQL++H G +  FHF      +  + +R+ VK  LQ  +P+FK KA  ELE K ++ + +P +  LY++LV ++ +  EEFW    S  S  SSV   S  + GI +  LA   PQ DG +  + NL+  ++E IF  YPAVK K+ + VP+ M+E++FW +FFQSHYFHR + +  + D F  CA  D + ++    +  K     L+ ++DK       C+ +  G S    T      K +S+  +++RFN  S ++L     K+ ++    S+    D  +          +    +E   +E    D+  G+K    N  K  +Y +  +      + SQ  A  + +       L  +  +KQ +     R L  ++SS  A   T  LT  G L       +    QQ  N   +P ++  ++K LY    EL RHFW CFPV      EKL   +E +
Sbjct:    1 MATSSEEVLLIVKKVRHKKQDGALYLMAERVAWAPEGKDRFTISHMYADIKCQKISPDGKAKVQLQLVLHVGETTNFHF---SNDATAIKERDAVKELLQQLLPKFKRKANKELEEKNRMLKEDPVLFQLYKDLVVSQVISAEEFWANRLSLNSLDSSVLA-SKQDVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKLKYAENVPHNMTEKDFWKQFFQSHYFHRDRLNTGAKDLFAECAKMDERGLKSMVSQGVKNPMLDLMALEDK-------CLEEGYGISSAPSTSSTKSIKENSNAAIIKRFNHHSAMVLAAGLRKDEAQSDQCSETSSTDGNSRDSDFFLPPVKKVKLQE--AIEYEDLDQSNGMKPLVLNLKKSDRYYHGPTP-----IQSQQYASSQDI-------LSSIHSIKQQMENYTPR-LTQVLSSGAASSTTAALTPGGAL-------MQGVTQQAINQ-LVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKLTGHLEEM 496
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Mouse
Match: Gtf2h1 (general transcription factor II H, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1277216])

HSP 1 Score: 231.106 bits (588), Expect = 7.537e-68
Identity = 158/550 (28.73%), Postives = 269/550 (48.91%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDL-SNDKFGSCAYYDIQQIEKEAQRLKKESLI---LIQDKT--EDVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEK-STFDRLEGVKFNTDKVSQY------INRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYILT 1655
            ++ S+E+++ ++  V  KK +G LYLM ER+AW     D F IS  Y +I+ Q+ISP+ K K+QLQL++H+G +  FHF      S  V +R+ VK  LQ  +P+FK KA  ELE K ++ + +P +  LY++LV ++ +  EEFW     N++   S       + GI +  LA   PQ DG +  + NL+  ++E IF  YPAVK K+ + VP+ M+E+EFW +FFQSHYFHR + +  S D F  CA  D + ++       K  ++    ++DK   E  G   VP  +    NS + K +S+  +++RFN  S ++L     K  ++   + +   +D  +        + +    +E    E     + ++ +  N  K  +Y      I  +  +   ++ +   + R+ ++ +  +  + L+    +  +T   P   LM                           QQ  N   +P ++  ++K LY    EL RHFW CFPV      EK+ +M   +++F++ K+  F ++    Y+ T
Sbjct:    1 MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGKAKIQLQLVLHAGDTTNFHF---SNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWAN-RLNVNATDSSTSSHKQDVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKMKYAETVPHNMTEKEFWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPMLDLTSLEDKPLDEGYGISSVPSTS----NSKSIKENSNAAIIKRFNHHSAMVLAAGLRKQQAQNGQNGEPSSVDGNSGDTDCFQPAVKRAKLQESIEYEDLGNNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQVLSSSAASSTITALSPGGALMQGGT-----------------------QQAVNQ-MVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLST 518
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Mouse
Match: Gtf2h1 (general transcription factor II H, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1277216])

HSP 1 Score: 231.106 bits (588), Expect = 7.684e-68
Identity = 158/550 (28.73%), Postives = 269/550 (48.91%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDL-SNDKFGSCAYYDIQQIEKEAQRLKKESLI---LIQDKT--EDVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEK-STFDRLEGVKFNTDKVSQY------INRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYILT 1655
            ++ S+E+++ ++  V  KK +G LYLM ER+AW     D F IS  Y +I+ Q+ISP+ K K+QLQL++H+G +  FHF      S  V +R+ VK  LQ  +P+FK KA  ELE K ++ + +P +  LY++LV ++ +  EEFW     N++   S       + GI +  LA   PQ DG +  + NL+  ++E IF  YPAVK K+ + VP+ M+E+EFW +FFQSHYFHR + +  S D F  CA  D + ++       K  ++    ++DK   E  G   VP  +    NS + K +S+  +++RFN  S ++L     K  ++   + +   +D  +        + +    +E    E     + ++ +  N  K  +Y      I  +  +   ++ +   + R+ ++ +  +  + L+    +  +T   P   LM                           QQ  N   +P ++  ++K LY    EL RHFW CFPV      EK+ +M   +++F++ K+  F ++    Y+ T
Sbjct:    7 MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGKAKIQLQLVLHAGDTTNFHF---SNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWAN-RLNVNATDSSTSSHKQDVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKMKYAETVPHNMTEKEFWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPMLDLTSLEDKPLDEGYGISSVPSTS----NSKSIKENSNAAIIKRFNHHSAMVLAAGLRKQQAQNGQNGEPSSVDGNSGDTDCFQPAVKRAKLQESIEYEDLGNNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQVLSSSAASSTITALSPGGALMQGGT-----------------------QQAVNQ-MVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLST 524
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Mouse
Match: Gtf2h1 (general transcription factor II H, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1277216])

HSP 1 Score: 119.398 bits (298), Expect = 4.004e-31
Identity = 56/143 (39.16%), Postives = 91/143 (63.64%), Query Frame = 3 
Query:   45 MSNVSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYM 473
            ++ ++ S+E+++ ++  V  KK +G LYLM ER+AW     D F IS  Y +I+ Q+ISP+ K K+QLQL++H+G +  FHF      S  V +R+ VK  LQ  +P+FK KA  ELE K ++ + +P +  LY++LV ++ +
Sbjct:    4 IAIMATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGKAKIQLQLVLHAGDTTNFHF---SNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQEDPVLFQLYKDLVVSQVI 143
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Mouse
Match: Gtf2h1 (general transcription factor II H, polypeptide 1 [Source:MGI Symbol;Acc:MGI:1277216])

HSP 1 Score: 45.4394 bits (106), Expect = 3.850e-6
Identity = 20/51 (39.22%), Postives = 32/51 (62.75%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIR 206
            ++ S+E+++ ++  V  KK +G LYLM ER+AW     D F IS  Y +I+
Sbjct:    1 MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIK 51
[Close]
BLAST of General transcription factor iih subunit 1 vs. UniProt/SwissProt
Match: sp|Q960E8|TF2H1_DROME (General transcription factor IIH subunit 1 OS=Drosophila melanogaster OX=7227 GN=Tfb1 PE=2 SV=1)

HSP 1 Score: 242.276 bits (617), Expect = 7.202e-71
Identity = 179/573 (31.24%), Postives = 287/573 (50.09%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLATPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFK-SDLSNDKFGSCAYYDIQQIEKEAQRLKKESLILIQDKTEDVGEFCVPDNTG-KSVNSDTQKSSSS----EELLRRFNRQSFLILKTMKS--------KNTSKRAND-------------------------SDCVDLDSG-NEKRRLIDSSSEMYSEEERFVLEKSTFDRLEGVK---FNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRL-AGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQG---RNAGKLPP-EMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGF 1622
            ++ S+ED++  +  V YKK +G LY+M ER+AWM    D   +S  Y +I+ Q+ISP+ K KVQLQ+++H G++ TFHF++  G++  ++DR+ VK  LQ  +P FK K   +LE+K ++   NP +L LY++LV  K +  +EFW     + + +       +   G  ++L    PQ DG +  + NL+  ++  IF  YPAVK+KH + VP +MSE EFW KFFQSHYFHR + +  + D F  C   D Q ++   Q+   + L+ ++ K ED     VP   G  SV  D    +S     + +++RFN+ S ++LKT  +         N +  AN                          SD VD D   ++K+RL++     Y +    +LE       E  K   F   KV +Y+N      V N    +  D   L++ Q + +R   + L +N+  T        + S  A + L          +++    + +G   ++AG+L P +  R+++ LY   SEL +HFW CFP T      KL RM E +++F++ K+  F
Sbjct:    1 MTTSSEDVLLQMGEVRYKKGDGTLYVMNERVAWMAEHRDTVTVSHRYADIKTQKISPEGKPKVQLQVVLHDGNTSTFHFVNRQGQAAMLADRDKVKELLQQLLPNFKRKVDKDLEDKNRILVENPNLLQLYKDLVITKVLTSDEFWATHAKDHALKKMGRSQEIGVSG--AFLADIKPQTDGCNGLKYNLTSDVIHCIFKTYPAVKRKHFENVPAKMSEAEFWTKFFQSHYFHRDRLTAGTKDIFTECGKIDDQALKAAVQQGAGDPLLDLK-KFED-----VPLEEGFGSVAGDRNVVNSGNIVHQNMIKRFNQHSIMVLKTCANVTSAPSTMTNGTNNANGPVSQSAYTNGMNGKGQATATATKSSSDQVDKDEPQSKKQRLMEKIH--YVDLGDPILEGDDSANGEKAKSKHFELSKVERYLN----GPVQNSMYDNHNDPMSLEEVQYKLVRNSESWLNRNVQRT-------FICSKAAVNAL---------GELSPGGSMMRGFQEQSAGQLVPNDFQRELRHLYLSLSELLKHFWSCFPPTSEELETKLQRMHETLQRFKMAKLVPF 543
[Close]
BLAST of General transcription factor iih subunit 1 vs. UniProt/SwissProt
Match: sp|P32780|TF2H1_HUMAN (General transcription factor IIH subunit 1 OS=Homo sapiens OX=9606 GN=GTF2H1 PE=1 SV=1)

HSP 1 Score: 233.032 bits (593), Expect = 8.930e-68
Identity = 162/551 (29.40%), Postives = 273/551 (49.55%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFW-QRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDL-SNDKFGSCAYYDIQQIEKEAQRLKKESLI---LIQDKT--EDVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEK-STFDRLEGVKFNTDKVSQY------INRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYILT 1655
            ++ S+E+++ ++  V  KK +G LYLM ER+AW     D F IS  Y +I+ Q+ISP+ K K+QLQL++H+G +  FHF      S  V +R+ VK  LQ  +P+FK KA  ELE K ++ + +P +  LY++LV ++ +  EEFW  R   N +  SS + +   + GI +  LA   PQ DG +  + NL+  ++E IF  YPAVK K+ + VP+ M+E+EFW +FFQSHYFHR + +  S D F  CA  D + ++       K  L+    ++DK   E  G   VP  +    NS + K +S+  +++RFN  S ++L     K  ++    S+  ++D  +        + +    +E    E     + ++ +  N  K  +Y      I  +  +   ++ +   + R+ ++ +  +  + L+    +  +T   P   LM                           QQ  N   +P ++  ++K LY    EL RHFW CFPV      EK+ +M   +++F++ K+  F ++    Y+ T
Sbjct:    1 MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGKAKIQLQLVLHAGDTTNFHF---SNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQ-DVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSAS----NSKSIKENSNAAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEYEDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQVLSSSAASSTITALSPGGALMQGGT-----------------------QQAINQ-MVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLST 519
[Close]
BLAST of General transcription factor iih subunit 1 vs. UniProt/SwissProt
Match: sp|Q9DBA9|TF2H1_MOUSE (General transcription factor IIH subunit 1 OS=Mus musculus OX=10090 GN=Gtf2h1 PE=1 SV=2)

HSP 1 Score: 229.95 bits (585), Expect = 1.235e-66
Identity = 158/550 (28.73%), Postives = 269/550 (48.91%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDL-SNDKFGSCAYYDIQQIEKEAQRLKKESLI---LIQDKTEDVGEFC--VPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEK-STFDRLEGVKFNTDKVSQY------INRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYILT 1655
            ++ S+E+++ ++  V  KK +G LYLM ER+AW     D F IS  Y +I+ Q+ISP+ K K+QLQL++H+G +  FHF      S  V +R+ VK  LQ  +P+FK KA  ELE K ++ + +P +  LY++LV ++ +  EEFW     N++   S       + GI +  LA   PQ DG +  + NL+  ++E IF  YPAVK K+ + VP+ M+E+EFW +FFQSHYFHR + +  S D F  CA  D + ++       K  ++    ++DK  D G     VP  +    NS + K +S+  +++RFN  S ++L     K  ++   + +   +D  +        + +    +E    E     + ++ +  N  K  +Y      I  +  +   ++ +   + R+ ++ +  +  + L+    +  +T   P   LM                           QQ  N   +P ++  ++K LY    EL RHFW CFPV      EK+ +M   +++F++ K+  F ++    Y+ T
Sbjct:    1 MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGKAKIQLQLVLHAGDTTNFHF---SNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWAN-RLNVNATDSSTSSHKQDVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKMKYAETVPHNMTEKEFWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPMLDLTSLEDKPLDEGYSISSVPSTS----NSKSIKENSNAAIIKRFNHHSAMVLAAGLRKQQAQNGQNGEPSSVDGNSGDTDCFQPAVKRAKLQESIEYEDLGNNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQVLSSSAASSTITALSPGGALMQGGT-----------------------QQAVNQ-MVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLST 518
[Close]
BLAST of General transcription factor iih subunit 1 vs. UniProt/SwissProt
Match: sp|Q55FP1|TF2H1_DICDI (General transcription factor IIH subunit 1 OS=Dictyostelium discoideum OX=44689 GN=gtf2h1 PE=3 SV=1)

HSP 1 Score: 69.3218 bits (168), Expect = 5.671e-11
Identity = 64/255 (25.10%), Postives = 125/255 (49.02%), Query Frame = 3 
Query:  291 IHPDG---------RSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRK--LCENNPQILDLYRELVT-NKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKSQCN--LSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDLSNDKFGSCAYYDIQQIEKEAQRLKKESLILIQDKTE--DVGEFCVPDNTGKSV----NSDTQKSSSSEELLRRFNRQSFLIL 992
            ++PDG         +  QV ++   K     ++ + K+ + SE + K++  L ++N ++ +LY ++V  ++ + + +FW+  +S +   S+ +E    + G+PS LLA   P  +  +  +   +  ++  IF  +P+V++ +   VP ++SE+ FW K+ QS YF+R +S  +        +   +  E+   R+ K  LI I    +      F    ++G  V    + D  K   +  LLR+FNR S L+L
Sbjct:  147 VNPDGTITNDPLSSQPAQVEEKAETK-----YLSKLKQPSLSEQQIKQRVILLQSNKELRELYEQMVNKDRVISESDFWESRKSMLKNDSTRSEKQ--HTGMPSNLLADVRPSSETPNAVHYRFTPTVIHQIFIQHPSVEKAYKANVPLKISEQNFWKKYVQSKYFYRDRSSANAPPVDDDLFSKYETDEQNKIRILKRKLIDINPLVDLSSTDGFDTDVHSGYGVLLDQSQDPNKLEKALPLLRKFNRHSALVL 394
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BLAST of General transcription factor iih subunit 1 vs. UniProt/SwissProt
Match: sp|Q9M322|TFB1C_ARATH (General transcription and DNA repair factor IIH subunit TFB1-3 OS=Arabidopsis thaliana OX=3702 GN=TFB1-3 PE=2 SV=2)

HSP 1 Score: 67.0106 bits (162), Expect = 2.447e-10
Identity = 65/241 (26.97%), Postives = 114/241 (47.30%), Query Frame = 3 
Query:   78 VKLIDHVSYKKTEGKLYLMTERLAWMTN--TSDV-FKISEHYKNIRAQRISPDDKDKVQ-LQLLMHSGSSFTFHFI-HPDGRS------KQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLL-ATPPQKDGKSQ---CNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFK 755
            VK    V    T G L L    L ++ N   SD+  K+  H  NI++Q+ + +  +K   L L    G S  F F  +PD  +      K ++        L    P  ++ + +E E + KL   N ++  L+++ V +K + ++EFW   +  + + S     S    G+ S ++    P  DG++     NL+ +++  IFA  PAV+Q     VP +M+E++FW K+F++ Y +  K
Sbjct:    5 VKYKSFVKDPGTLGSLELSEVMLLFVPNDPKSDLKLKVQTH--NIKSQKYTKEGSNKPPWLNLTSKQGRSHIFEFENYPDMHACRDFITKALAKCEEEPNKLVVLTPA-EQLSMAEFELRFKLLRENSELQKLHKQFVESKVLTEDEFWSTRKKLLGKDSI--RKSKQQMGLKSMMVSGIKPSTDGRTNRVTFNLTSEIIFQIFAEKPAVRQAFINYVPKKMTEKDFWTKYFRAEYLYSTK 240
[Close]
BLAST of General transcription factor iih subunit 1 vs. TrEMBL
Match: A0A5K3FJV4 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 300.827 bits (769), Expect = 2.132e-90
Identity = 206/583 (35.33%), Postives = 310/583 (53.17%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAE------------------------SNISQQSSVNEYSMYNR----GIPSWLLA-TPPQKDGKSQC--NLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDLS-NDKFGSCAYYDIQQIEKEAQRLKK----ESLILIQDKTEDVGE-FCV---PDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMK----SKNTSKRANDSDCVDLD-SGNEKRRLIDSSSEMYSEEERFVLE-KSTFDRLEGVKFNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQGRNAG-------------KLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFV 1625
            +SK +ED++ ++ HV +KK +G LY+ + R+AW   TSD F+IS  +++IR QR+S D+KDKVQLQLLMH+G SFTFHF    GR KQ+  RN VK  LQ  +P+FK+KA SEL  K +L E+NP +L LY+ELV    +  EEFW R E                        +++S+  +++   M +R    G+PS LL+   P+ DG +    NL+++ ++ IF  YPAV+Q+H +LVP+++SE +FW KFFQSHY+HR ++ ++ +D F  C   D + + +E  R +K      L L + +   VG+ + V   P  T  ++NS  QK+S+++ LLRRFN+ S +I++++     +  ++    DS   DL  SG+ KRRL  S     +   R  LE  ST D LEG                      + +QSTA    L Q Q  Q           AL  CR  ++ M +     +  + G   + ADV+   C+  G  +               L  E  +++ +LY  + EL RHFW CFPVT  A  EK+ R+ E++ +F   K+  FV
Sbjct:    1 MSKLSEDVLLMVKHVRHKKVDGTLYVNSGRVAWRNQTSDSFRISAAFEDIRLQRVSLDNKDKVQLQLLMHNGESFTFHFADTAGREKQLEMRNKVKEMLQLMLPKFKDKAHSELNEKYRLLESNPHLLALYKELVVTGILSSEEFWARPEFSQPRMVGAASTTSPGSKEGTNHTASVSRSPAMSTKLMQDRAQISGVPSCLLSDIKPEMDGTNSIKYNLTQETIDAIFRAYPAVRQRHRELVPDKLSEADFWIKFFQSHYYHRDRAIINKDDVFSECDSLDDRILRQELIRSRKLRSSAHLDLGELEDHSVGQGYGVELQPPPTDSTINSK-QKASTNQILLRRFNKHSIMIMRSLARFSGATPSTTTTADSSYKDLVLSGSLKRRLYQSELCEEAPGPRADLELTSTKDYLEG--------------------PTMLTQSTAS--PLTQSQARQ-----------ALAACRASLS-MPNRGGRLLFNNNGVHKAIADVSAGGCLMAGGKSATGEKSGAPSSVLLLLSSEQSKELSILYSAAGELLRHFWSCFPVTSVALAEKVVRIHESLGRFETTKLTPFV 548
[Close]
BLAST of General transcription factor iih subunit 1 vs. TrEMBL
Match: A0A0R3WSZ0 (Uncharacterized protein OS=Hydatigena taeniaeformis OX=6205 GN=TTAC_LOCUS3866 PE=4 SV=1)

HSP 1 Score: 297.36 bits (760), Expect = 4.714e-89
Identity = 208/643 (32.35%), Postives = 314/643 (48.83%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYN-----------------------------RGIPSWLLA-TPPQKDGKSQC--NLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDLS-NDKFGSCAYYDIQQIEKEAQRLKKESLILIQDKTEDVGEFCVPDNTG--------KSVNSDTQKSSSSEELLRRFNRQSFLILKTMK----SKNTSKRANDSDCVDL-DSGNEKRRLIDSSS----EMYSEEERFVLEKSTFDRLEGVKFNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHL-FSDADVAVSSCIQQ------GRNAGK-------LPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQ----------HPNYYILTGSMDSKPIDHLCKMTDRVNEAFERYMANYKRINKA 1760
            +SK +ED++ ++ HV YKK +G LY+ + R+AW   TSD F+IS  +++IR QR+S D+K+KVQLQLLMHSG SFTFHF    GR KQ+  RN VK  LQ  +P+FK+KA SEL  K ++ E+NP +L LY+ELV    +  EEFW R E   SQ  SV   ++ +                              G+PS LL+   P+ DG +    NL++++++ IF  YPAV+Q+H  LVP+++SE +FWNKFFQSHY+HR +  ++ +D F  C   D + + +E  R +K  L    D   D+ +  V +  G           ++  QK ++++ LL RFN+ S LI++ +        ++   N+S   DL  SGN KRR  ++ +    ++ S E    + K  F                    S S+V   T  S      L Q Q  Q           AL  CR   +L  SS    +L +   +  + ADV+   C+        G  AG        L PE  +++ +LY    EL RHFW C P T  A  EK+ R+ E++ +F   K+  F++             N    TG    +   HL  + +   + F  + A  +R++ +
Sbjct:    1 MSKKSEDVLLMVKHVRYKKVDGTLYVNSGRIAWRNQTSDSFRISAAFEDIRLQRVSLDNKEKVQLQLLMHSGESFTFHFADTAGRGKQLEMRNKVKEMLQLMLPKFKDKAHSELNEKFRILESNPHLLSLYKELVVTGILSSEEFWARPE--FSQSKSVGSTALSSVGTKDGTTQSQCVSRSGISVNLTQERTQIAGVPSCLLSDIKPEMDGTNSIKYNLTKEIIDAIFRAYPAVRQRHRDLVPDKLSEADFWNKFFQSHYYHRDRGIINQDDVFSECDGLDEKILRQELLRCRKMRLASHLD-VGDLEDHSVGEGYGVEPPLPPPNPTSNAKQKVNTNQLLLHRFNKHSILIMRALAKYSAGAASTAATNESAYRDLAASGNLKRRFYETEACKNPKISSSELELAVTKDYFQ-------------------SPSSVMQSTVSS------LTQSQARQ-----------ALAACR--ASLSVSSRGGRLLFNNNDVQLAIADVSAGGCLMAGGKSATGEKAGAPSSVLLLLSPEQSKELSMLYSAVGELLRHFWVCLPTTTVAMAEKIIRIHESLGRFETTKLTPFIESVESTLSSAGVRGNGGSATGVYRCRVTAHLESLINAAKDKFNEWHAGQQRLSNS 602
[Close]
BLAST of General transcription factor iih subunit 1 vs. TrEMBL
Match: A0A504YJY6 (Transcription initiation factor TFIIH subunit 1 OS=Fasciola gigantica OX=46835 GN=FGIG_05352 PE=4 SV=1)

HSP 1 Score: 300.056 bits (767), Expect = 6.065e-89
Identity = 216/668 (32.34%), Postives = 317/668 (47.46%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAE-------------------SNISQQSSVNEYSMYNR------------------GIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDLS-NDKFGSCAYYDIQQIEKEAQRLKK---------ESL----ILIQDKTE-DVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLD---------------SGNEKRRLIDSSSEMYSEEERFVLEKSTFDRLEGVKFNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATD------VLTDIGHLFSDADVAVSSCIQQGR-------------------------------NAGKLPP-------------------EMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQ-HPNYYILTGSMDSKP 1676
            +SK  ED++ ++ HV YKK +G LY+ + RLAW   TSD F+IS  +++IR QRISPD K+KVQLQLLMH+G SFTF F  P GR KQ+  RNNVK  LQ  +P+FK+KAQSEL  K +L E+NP +L LY+ELV    +  +EFW R E                   S  S  ++VN  +  +                   G+PS+LL+   P+ DG +  + NL+ + +  IF  YP V+Q+H +LVP++++E +FW KFFQSHYFHR +  L   D F  CA  D +Q++ E +R ++         ESL    + I   TE D      P  +      D    S+++ LLRRFN  S LILK++ S +    A+   CV +D               +  +  R I    ++YS E     E   F RLE        VS Y+   +S      T++++ ++  +   +    +       + A  RC+   +LM S+ A        +LT +    + ADV+   C+  G+                                +G   P                   E  R++ LLY  +SEL RHFW CFPVT+    EKL R+  ++ +FR+ K+  F     P     +GS++S P
Sbjct:    1 MSKQKEDVLLMVKHVRYKKVDGTLYVNSGRLAWRNQTSDSFRISAAFEDIRVQRISPDQKEKVQLQLLMHNGESFTFQFADPAGRVKQLEMRNNVKEMLQRLLPKFKDKAQSELREKVRLLESNPDLLALYKELVVTGILSSDEFWARPEFSTTNNTSSEAPTQSSQRKSQGSTATAVNTTTGGSNSTGQISRSFQLDDQPQTVGVPSYLLSDIKPEADGANGIKYNLTHETINAIFRAYPTVRQRHKELVPDKLTEADFWIKFFQSHYFHRDRVQLPKEDIFADCAAQDERQLQTELRRSRRNRISAHLDLESLSDHELGIGYGTEIDPLPTVRPSESLSKSTEDGSNISANQLLLRRFNNHSILILKSLGSGDV---ASGLSCVPMDGIGGSVDQSSQSQTATTTDSARAISLKQQIYSSELTDDPEPPHF-RLE-----LASVSDYLEGPTSKEQGASTTRTSLNQNSIAPAR-PYAQSTTTTHASEASERCK---SLMRSAYAGGRKAKNVLLTTMDAQLALADVSPGGCLVGGKRSDELKGSRSTERPDSVDTTGCRGVDNNRLMGSGSTGPRRSAQDAEEVDRGPALLNAEQARELSLLYASASELLRHFWACFPVTNPELAEKLDRIANSLTRFRVSKVAHFAASLDPTMGGSSGSLNSNP 655
[Close]
BLAST of General transcription factor iih subunit 1 vs. TrEMBL
Match: A0A4E0R6K6 (Transcription initiation factor TFIIH subunit 1 OS=Fasciola hepatica OX=6192 GN=D915_006541 PE=4 SV=1)

HSP 1 Score: 295.434 bits (755), Expect = 2.833e-87
Identity = 217/658 (32.98%), Postives = 312/658 (47.42%), Query Frame = 3 
Query:   54 VSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAE-------------------SNISQQSSVNEYSMYNR------------------GIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDLS-NDKFGSCAYYDIQQIEKEAQRLKK---------ESL----ILIQDKTE-DVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDS-------GNEKRRLIDSSS--------EMYSEE-------ERFVLE-KSTFDRLEGVKFNTDKVSQYINRISSSNVA--------NVTSQSTADRKRLKQFQDEQLRR--------LAGLKQNLALTRCRPLVNLMS-----------SSVATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLL-----------YRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQ-HPNYYILTGSMDSKP 1676
            +SK  ED++ ++ HV YKK +G LY+ + RLAW   TSD F+IS  +++IR QRISPD K+KVQLQLLMH+G SFTF F  P GR+KQ+  RNNVK  LQ  +P+FK+KAQSEL  K +L E+NP +L LY+ELV    +  +EFW R E                   S  S  ++VN  +  +                   G+PS+LL+   P+ DG +  + NL+ + +  IF  YP V+Q+H +LVP++++E +FW KFFQSHYFHR +  L   D F  CA  D +Q++ E +R ++         ESL    + I   TE D      P  +      D    S+++ LLRRFN  S LILK++ S +    A+   CV +D         N+ +  I + S        ++YS E         F LE  S  D LEG        S     ++ ++VA          T+ ++    R K                 L  +   LAL    P   L+            S+   D +   G    D +  + S     R + +   E+ R   LL           Y  +SEL RHFW CFPVT+    EKL R+  ++ +FR+ K+  F     P     +GS++S P
Sbjct:    1 MSKQKEDVLLMVKHVRYKKVDGTLYVNSGRLAWRNQTSDSFRISAAFEDIRVQRISPDQKEKVQLQLLMHNGESFTFQFADPAGRAKQLEMRNNVKEMLQRLLPKFKDKAQSELREKVRLLESNPDLLALYKELVVTGILSSDEFWARPEFSTTNNTSSEAPTQSSQRKSQGSTATAVNTTTGGSNSTGQISRSFQLDDQPQTVGVPSYLLSDIKPEADGANGIKYNLTHETINAIFRAYPTVRQRHKELVPDKLTEADFWIKFFQSHYFHRDRVQLPKEDIFADCAAQDERQLQTELRRSRRNRISAHLDLESLSDHELGIGYGTEIDPLPTVRPSESSSKSTEDGSNISANQLLLRRFNNHSILILKSLGSGDV---ASGLSCVPMDGIGGSVDQSNQSQTAITTDSARATSLKQQIYSSELTDDPEPPHFRLELASVSDYLEGPTSKEQGASTTRTSLNQNSVAPARPYAQSTTTTHASEASARCKSSMRSAYAGGRKAKNVLLTTMDAQLALADVSPGGCLVGGKRSDELKGSRSTERPDSVDTTGCRGVDNNRLMGSGSTGPRRSAQDAEEVDRGPALLNAEQARELSLLYASASELLRHFWACFPVTNPELAEKLDRIANSLTRFRVSKVAHFAASLDPTMGGSSGSLNSNP 655
[Close]
BLAST of General transcription factor iih subunit 1 vs. TrEMBL
Match: A0A0R3T7R8 (Uncharacterized protein OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS3105 PE=4 SV=1)

HSP 1 Score: 288.5 bits (737), Expect = 1.038e-85
Identity = 199/589 (33.79%), Postives = 305/589 (51.78%), Query Frame = 3 
Query:   45 MSNVSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAE--------------SNISQQSSVNEYSMYNRGIPSWLLATPPQKDGKSQC-----------------NLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDLS-NDKFGSCAYYDIQQIEKEAQRLKKESLI--LIQDKTED--VGE---FCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNT-----SKRANDSDCVDL-DSGNEKRRLIDSSSEMYSEEERFVLEKSTFDRLEGVKFNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRC--RPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQG-------RNAGK-------LPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQ 1628
            MS  SK +ED++ ++ HV +KK +G LY+ + R+AW   TSD F+IS  +++IR QR+S D ++KVQLQLLMHSG SFTFHF  P G+ KQ+  RN VK  LQ  +P+FK+KA  EL  K  + E+NP +L LY+ELV    +  EEFW R E              S +S+   V    + ++GI   L+   PQ  G S C                 NL++  ++ IF  YPAV+Q+H +LVP++++E EFWNKFFQSHY+HR ++ ++ +D F  C   D + +  E  R ++   +  L  D  ED  VGE     +P+ +  S ++  Q+ ++++ L+ RFN+ S LIL++ ++K+T     +K + DS   DL  SG  KR+L   ++          +E  +    E +  +  K   Y     + N A+  SQ       L Q Q  Q   LA  + +L ++    RP +N        DV + I      ADV+   C+  G       + AG        L  E  +++ +L   + EL RHFW C P T  A  EK+ R+ +++ +F   K+  F++
Sbjct:    1 MSKNSKQSEDVLFMVKHVRHKKVDGTLYVNSGRIAWRNQTSDTFRISAAFEDIRMQRVSLDSREKVQLQLLMHSGESFTFHFADPAGQKKQIEARNKVKEVLQQMLPKFKDKAHVELNEKFCILESNPHLLALYKELVVTGILSSEEFWARPEFSQAKSIGSVESVASGVSKDEYVPPQWISSKGISLSLVPELPQVAGVSSCLLSDIKPEMDGANSIRYNLTKDSIDAIFRAYPAVRQRHKELVPDKLTEPEFWNKFFQSHYYHRDRAVINKDDIFNDCDEVDEKMLHSEFLRCRRMRTVSHLDFDSLEDHSVGEGYGLDLPEQSQLSPSNSKQRGNTNQLLIHRFNKHSNLILRS-QAKHTAMTAPAKPSMDSTYRDLASSGTLKRKLTVPAA---------AIEDPSKKPRESITLSVTK--DYFQNPITFNQASPISQG------LSQSQARQA--LAACQASLGVSNGGNRPTLNY------ADVQSAI------ADVSAGGCLTTGGKTASGEKTAGTPSSVLMLLSTEQSKELSMLISAAGELLRHFWVCLPTTSIAMAEKIIRIHDSLLRFETNKLIPFIE 557
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Cavefish
Match: gtf2h1 (general transcription factor IIH subunit 1 [Source:NCBI gene;Acc:103045288])

HSP 1 Score: 225.328 bits (573), Expect = 5.760e-66
Identity = 162/556 (29.14%), Postives = 265/556 (47.66%), Query Frame = 3 
Query:   66 TEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDLS-NDKFGSCAYYD---IQQIEKEAQRLKKESLILIQDKT--EDVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEKSTFDRLEG---VKFNTDKVSQY------INRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSS--------VATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYILT 1655
            +E+++ ++  V  +K +G LYLMTER+AW     D F +S  Y +IR Q+ISPD K K+QLQL++H+G S TFHF +    S  + DR+  K  LQ  +P+FK+KA  +LE K K+ + +P +  LY++LV ++ +  EEFW       S + S++  S    GI +  LA   PQ DG +  + NL+  ++E IF  YPAVKQK+ + VP+ ++E+EFW +FFQSHYFHR + +    D F  CA  D   ++ +  +  +     L+ ++DKT  E  G   V  N+ K+V     K +S+  +++RFN  S ++L     K  +     S+    D  +          +    +E   +E        G   +  N  K  +Y      +     S   ++ +     ++ +  ++    R +     + A+T   P   LM +         V TDV +++ HL++ A                                 EL RHFW CFPV      EK+ +M   +++F+  K+  F ++    Y+ T
Sbjct:    5 SEEVLLVVKRVRQRKQDGTLYLMTERIAWGPEGKDRFTVSHLYADIRCQKISPDGKSKIQLQLVLHTGESTTFHFAN---ESTALKDRDAAKDLLQQLLPKFKKKANKQLEEKNKMLQEDPVLFQLYKDLVVSQVISAEEFWASRLKLSSVEHSLSNNSKQEVGISAAFLADIRPQTDGCNGLKYNLTSDIIESIFKTYPAVKQKYAENVPHNLTEKEFWTRFFQSHYFHRDRINTGQQDIFSECAKQDEKGLKSMVVQGVKNPMVDLLSLEDKTLDEGYGSLTVGPNSSKTV-----KENSNSAIIKRFNHHSAMVLAAGLRKVDAPSDQASETSSTDGNSRDSDFFQPPIKKVKLQE--AIEYEDLQNGSGPKTIALNLKKSDRYSHGPVPLQSHHYSTSQDIINSVNCIQEEISCYKPCLTRVMPSSAASSAITALSPGGLLMQAGTQQAVSQLVPTDVQSELKHLYTAA--------------------------------GELLRHFWSCFPVNTPFLEEKVVKMRSNLERFQSTKLRPFQEKIQREYLST 518
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Cavefish
Match: gtf2h1 (general transcription factor IIH subunit 1 [Source:NCBI gene;Acc:103045288])

HSP 1 Score: 224.942 bits (572), Expect = 9.741e-66
Identity = 165/563 (29.31%), Postives = 268/563 (47.60%), Query Frame = 3 
Query:   66 TEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDLS-NDKFGSCAYYDIQQIEKEAQRLKKES---LILIQDKT--EDVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEKSTFDRLEG---VKFNTDKVSQY------INRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSS--------VATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYI---LTGSMD 1667
            +E+++ ++  V  +K +G LYLMTER+AW     D F +S  Y +IR Q+ISPD K K+QLQL++H+G S TFHF +    S  + DR+  K  LQ  +P+FK+KA  +LE K K+ + +P +  LY++LV ++ +  EEFW       S + S++  S    GI +  LA   PQ DG +  + NL+  ++E IF  YPAVKQK+ + VP+ ++E+EFW +FFQSHYFHR + +    D F  CA  D + ++    +  K     L+ ++DKT  E  G   V  N+ K+V     K +S+  +++RFN  S ++L     K  +     S+    D  +          +    +E   +E        G   +  N  K  +Y      +     S   ++ +     ++ +  ++    R +     + A+T   P   LM +         V TDV +++ HL++ A                                 EL RHFW CFPV      EK+ +M   +++F+  K+  F ++    Y+   LT  +D
Sbjct:    5 SEEVLLVVKRVRQRKQDGTLYLMTERIAWGPEGKDRFTVSHLYADIRCQKISPDGKSKIQLQLVLHTGESTTFHFAN---ESTALKDRDAAKDLLQQLLPKFKKKANKQLEEKNKMLQEDPVLFQLYKDLVVSQVISAEEFWASRLKLSSVEHSLSNNSKQEVGISAAFLADIRPQTDGCNGLKYNLTSDIIESIFKTYPAVKQKYAENVPHNLTEKEFWTRFFQSHYFHRDRINTGQQDIFSECAKQDEKGLKSMVVQGVKNPMVDLLSLEDKTLDEGYGSLTVGPNSSKTV-----KENSNSAIIKRFNHHSAMVLAAGLRKVDAPSDQASETSSTDGNSRDSDFFQPPIKKVKLQE--AIEYEDLQNGSGPKTIALNLKKSDRYSHGPVPLQSHHYSTSQDIINSVNCIQEEISCYKPCLTRVMPSSAASSAITALSPGGLLMQAGTQQAVSQLVPTDVQSELKHLYTAA--------------------------------GELLRHFWSCFPVNTPFLEEKVVKMRSNLERFQSTKLRPFQEKIQREYLSTNLTSHLD 525
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Yeast
Match: TFB1 (Subunit of TFIIH and nucleotide excision repair factor 3 complexes; required for nucleotide excision repair, target for transcriptional activators; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000002719])

HSP 1 Score: 63.5438 bits (153), Expect = 4.346e-11
Identity = 42/143 (29.37%), Postives = 70/143 (48.95%), Query Frame = 3 
Query:  372 KEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQ------RAESNISQQSSVNEYSMYNRGIPSWLLATPPQKDGKSQCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSD--LSNDK 776
            KEK  + L+ ++ L + N  ++ +++E V N  +   EFW       RA + +S    V  Y++ +   P          + K   NLSR+ + +IF  YP VK+ +T  VP    E EFW +FF S  F + + +  + ND+
Sbjct:  171 KEKLLTNLKLQQSLLKGNKVLMKVFQETVINAGLPPSEFWSTRIPLLRAFA-LSTSQKVGPYNVLSTIKPV------ASSENKVNVNLSREKILNIFENYPIVKKAYTDNVPKNFKEPEFWARFFSSKLFRKLRGEKIMQNDR 306
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Nematostella
Match: EDO49292 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RH50])

HSP 1 Score: 214.542 bits (545), Expect = 2.581e-62
Identity = 169/549 (30.78%), Postives = 270/549 (49.18%), Query Frame = 3 
Query:   45 MSNVSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFW-QRAESN--ISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKSQCN-----LSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKS----DLSNDKFGSCAYYDIQQIEKEAQRLKKESLILIQDKTEDV-GEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTS-------KRANDSDCVDLDSGNEKRRLIDSSS----EMYSEEERFVLEKSTFDRLEGVKFNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKID 1616
            M+ VS+S+  ++  + +  YKK  G L L+T  L W    S   KI   Y  I+ QRISP+   KVQLQ+++H  SS++ HF   + +     +R++VK  L   IP  ++KA  ELE K ++ ++NP++  LY++LV +  +  +EFW  R +     S+ + VN+    + G+ S LLA   P+  G   CN     L+   +E IF  YPAVK+KH ++VP++M+E++FW KFFQSHYFHR +S      ++D F  CA  D    EKE    K   L LI D   D+ G   VP +  + V   ++ S+S++ L RR N  S ++L +  S +T+       +R    D    +   +K RL + +     + +S  E   L+  T ++  G       ++   + I   N A+VT+     +  +  +  +  + L+  +    LT   P  +LM     T    +I H  S      S  +QQ                  Y   +EL RHFW CFPV  +   EK+ RM ++++K+R  K++
Sbjct:    1 MAAVSESS--VLLTVINTKYKKNSGVLQLLTNNLTWSPQGSSAPKIDCKYSEIKVQRISPEGSSKVQLQVVLHDNSSYSIHFTGQNAKK----ERDDVKELLAQLIPAHRKKASKELEEKNRMLKDNPELYQLYKDLVVSGVITPDEFWANRGQDTGATSKSTGVNQ----SIGLSSALLADMQPESSG---CNEVKYSLNADTIETIFRTYPAVKKKHEEVVPDQMTEKDFWTKFFQSHYFHRDRSAETRPTASDMFTECAKQD----EKEQLASK---LNLISDPMLDLKGYGSVPCDVPEQV---SKNSTSTQSLFRRLNHHSLMVLHSTPSASTTSDGIPNEERNGTVDNQPAEPPAKKTRLREVTEYDDLQEHSPIEPISLKIVTRNKYSGGPVTLPGINGNTS-IPGHNAADVTTAIQYCQHEVNSWTPDLTQALSSDQACHVLTEISPGGSLME----TTSQANIHHTLS--STMKSEVLQQ------------------YMALTELLRHFWSCFPVKTAFLEEKVARMGQSLEKYRNTKLE 501
[Close]
BLAST of General transcription factor iih subunit 1 vs. Ensembl Medaka
Match: gtf2h1 (general transcription factor IIH subunit 1 [Source:NCBI gene;Acc:101155106])

HSP 1 Score: 212.616 bits (540), Expect = 3.883e-61
Identity = 123/340 (36.18%), Postives = 191/340 (56.18%), Query Frame = 3 
Query:   66 TEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLA-TPPQKDGKS--QCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDL-SNDKFGSCAYYDIQQIEKEAQRLKKESLI---LIQDKTEDVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKN--TSKRANDSDCVDLDS 1058
            +E+++ ++  V  +K +G LYLM ER+AW     D F +S  Y +IR Q+ISPD K KVQLQL++H+G S TFHF +    S  + DR   K  LQ  +P+FK+KA  ELE K ++ + +P +  LY++LV ++ +  EEFW      ++        +    GI    LA   PQ DG +  + NL+  ++E IF  YPAVKQK+++ VP+ ++E+EFW +FFQSHYFHR + +  + D F  CA  D + +     +  K  L+    ++DKT D G          S  + T K SS+  +++RFN  S ++L     KN   + +A+++   D +S
Sbjct:    5 SEEVLLVVKKVRQRKQDGTLYLMAERIAWGPEGKDRFTVSHPYSDIRCQKISPDGKAKVQLQLVLHTGESTTFHFAN---ESTALKDREAAKELLQQLLPKFKKKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWANRLGGLNNSEPAPYSNKQEVGISGAFLADIRPQTDGCNGLRYNLTTDIIESIFRTYPAVKQKYSENVPHSLTEKEFWTRFFQSHYFHRDRINTGTQDIFSECAKQDEKGLMSLVNKGVKNPLVDLLSLEDKTLDEGYGIKQALPSTSNTNKTVKESSNAAIIKRFNHHSAMVLAAGSRKNEVPADQASETSSTDGNS 341
[Close]
BLAST of General transcription factor iih subunit 1 vs. Planmine SMEST
Match: SMESG000055374.1 (SMESG000055374.1)

HSP 1 Score: 1189.1 bits (3075), Expect = 0.000e+0
Identity = 570/572 (99.65%), Postives = 570/572 (99.65%), Query Frame = 3 
Query:   45 MSNVSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLATPPQKDGKSQCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDLSNDKFGSCAYYDIQQIEKEAQRLKKESLILIQDKTEDVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEKSTFDRLEGVKFNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYILTGSMDSKPIDHLCKMTDRVNEAFERYMANYKRINKA 1760
            MSNVSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLATPPQKDGKSQCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDLSNDKFGSCAYYDIQQIEKEAQRLKKESL LIQDKTEDVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEKSTFDRLEGVKFNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDS GFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYILTGSMDSKPIDHLCKMTDRVNEAFERYMANYKRINKA
Sbjct:    1 MSNVSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLATPPQKDGKSQCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDLSNDKFGSCAYYDIQQIEKEAQRLKKESLTLIQDKTEDVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEKSTFDRLEGVKFNTDKVSQYINRISSSNVANVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVTDSTGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYILTGSMDSKPIDHLCKMTDRVNEAFERYMANYKRINKA 572
[Close]
BLAST of General transcription factor iih subunit 1 vs. Planmine SMEST
Match: SMESG000071924.1 (SMESG000071924.1)

HSP 1 Score: 381.333 bits (978), Expect = 4.948e-126
Identity = 226/570 (39.65%), Postives = 342/570 (60.00%), Query Frame = 3 
Query:   60 KSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHYKNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKISLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQRAESNISQQSSVNEYSMYNRGIPSWLLATPPQKDGKSQCNLSRQMVEDIFAVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDLSNDKFGSCAYYDIQQIEKEAQRLKKESL--ILIQDKTEDVGEFCVPDNTGKSVNSDTQKSSSSEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSSEMYSEEERFVLEKSTFDRLEGVKFNTDKVSQYINRISSSNVA--NVTSQSTADRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHLFSDADVAVSSCIQQGRNAGKLPPEMIRDIKL----LYRISSELFRHFWECFPVTDSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYILTGSMDSKPIDHLCKMTDRVNEAFERYMANYK 1745
            KSTED++ +I++VS+KKT+G LYLMTERLAW ++TSD+FKISE Y NI+ QRISPD+K  V++Q+++HS SS TF F +P+GR  Q SDR+ +K  L   +PRF+E AQ EL  K+KLCE NP I+ LY+ELV  +Y+CKEEFW R+ES + +     EY +  +G+PS+LLA+       S+   S++M++DI  VYP+VK+  T+   ++  +E+FW+KF QSHY+H FK   +ND F      DI  +++E+ +LK   +  ++  +  E + EF   +N+ K   +  Q  +SS++L+ R NR++  I +TMKSK   KR N    VDLD+  +K                         +LE  +F+ D++    +    SN+   N+  +S +   R       Q R+L  +K+       +P     SSSV+  VL +  HL+   D   ++   + +    +  +   +IK     +Y+  SELFRHFWECFPV     FEKL R+ EA+K+F+   IDGFV +H +YY++TGSMD+K IDHL  M ++++ A+++Y+ NYK
Sbjct:    4 KSTEDVIAVINNVSFKKTDGNLYLMTERLAWKSSTSDIFKISEFYINIKNQRISPDNKTDVKIQIILHSNSSLTFQFTNPEGRKSQFSDRDEIKNKLLVLLPRFREIAQVELGKKKKLCEINPLIITLYKELVNKQYICKEEFWIRSESTMEKSFQSYEY-ITQQGVPSFLLAS-----SSSKLQFSKKMIDDICRVYPSVKRSLTEKQLSDADQEKFWSKFSQSHYYHLFKLYQANDMFRVNEERDILLLKRESVKLKYPDIFTVISDNLGEHISEFY--NNSVKVPTNQVQTYTSSQQLIFRINRRNIFIQRTMKSK-AKKRPNSIQNVDLDADVKKV------------------------KLEHCQFHKDRLEDENSIFLDSNIIMRNIQKKSVS---RQISTDSIQFRKLKSVKKR------KP-----SSSVS--VLEECQHLYMKQDSVNNA---RAKIDTSVTDDHYNNIKTRLTEIYQAGSELFRHFWECFPVDSEEKFEKLFRINEAVKRFKENTIDGFVNEHCDYYLVTGSMDTKLIDHLKSMVEKIHSAYDKYVFNYK 521
The following BLAST results are available for this feature:
BLAST of General transcription factor iih subunit 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
GTF2H11.859e-6829.40general transcription factor IIH subunit 1 [Source... [more]
GTF2H11.859e-6829.40general transcription factor IIH subunit 1 [Source... [more]
GTF2H11.859e-6829.40general transcription factor IIH subunit 1 [Source... [more]
GTF2H11.859e-6829.40general transcription factor IIH subunit 1 [Source... [more]
GTF2H15.584e-3325.69general transcription factor IIH subunit 1 [Source... [more]
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BLAST of General transcription factor iih subunit 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
gtf-2H15.746e-4628.74General Transcription Factor homolog [Source:UniP... [more]
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BLAST of General transcription factor iih subunit 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Tfb17.185e-7231.24gene:FBgn0033929 transcript:FBtr0305616[more]
Tfb17.185e-7231.24gene:FBgn0033929 transcript:FBtr0087550[more]
Tfb17.185e-7231.24gene:FBgn0033929 transcript:FBtr0087548[more]
Tfb17.185e-7231.24gene:FBgn0033929 transcript:FBtr0087549[more]
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BLAST of General transcription factor iih subunit 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
gtf2h16.851e-6428.62general transcription factor IIH, polypeptide 1 [S... [more]
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BLAST of General transcription factor iih subunit 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rnf1681.964e-6931.19ring finger protein 168, E3 ubiquitin protein liga... [more]
rnf1689.883e-6931.07ring finger protein 168, E3 ubiquitin protein liga... [more]
rnf1684.214e-6830.89ring finger protein 168, E3 ubiquitin protein liga... [more]
rnf1688.680e-6830.95ring finger protein 168, E3 ubiquitin protein liga... [more]
rnf1688.884e-6631.70ring finger protein 168, E3 ubiquitin protein liga... [more]
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BLAST of General transcription factor iih subunit 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Gtf2h17.537e-6828.73general transcription factor II H, polypeptide 1 [... [more]
Gtf2h17.684e-6828.73general transcription factor II H, polypeptide 1 [... [more]
Gtf2h14.004e-3139.16general transcription factor II H, polypeptide 1 [... [more]
Gtf2h13.850e-639.22general transcription factor II H, polypeptide 1 [... [more]
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BLAST of General transcription factor iih subunit 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q960E8|TF2H1_DROME7.202e-7131.24General transcription factor IIH subunit 1 OS=Dros... [more]
sp|P32780|TF2H1_HUMAN8.930e-6829.40General transcription factor IIH subunit 1 OS=Homo... [more]
sp|Q9DBA9|TF2H1_MOUSE1.235e-6628.73General transcription factor IIH subunit 1 OS=Mus ... [more]
sp|Q55FP1|TF2H1_DICDI5.671e-1125.10General transcription factor IIH subunit 1 OS=Dict... [more]
sp|Q9M322|TFB1C_ARATH2.447e-1026.97General transcription and DNA repair factor IIH su... [more]
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BLAST of General transcription factor iih subunit 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5K3FJV42.132e-9035.33Uncharacterized protein OS=Mesocestoides corti OX=... [more]
A0A0R3WSZ04.714e-8932.35Uncharacterized protein OS=Hydatigena taeniaeformi... [more]
A0A504YJY66.065e-8932.34Transcription initiation factor TFIIH subunit 1 OS... [more]
A0A4E0R6K62.833e-8732.98Transcription initiation factor TFIIH subunit 1 OS... [more]
A0A0R3T7R81.038e-8533.79Uncharacterized protein OS=Rodentolepis nana OX=10... [more]
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BLAST of General transcription factor iih subunit 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
gtf2h15.760e-6629.14general transcription factor IIH subunit 1 [Source... [more]
gtf2h19.741e-6629.31general transcription factor IIH subunit 1 [Source... [more]
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BLAST of General transcription factor iih subunit 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of General transcription factor iih subunit 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
TFB14.346e-1129.37Subunit of TFIIH and nucleotide excision repair fa... [more]
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BLAST of General transcription factor iih subunit 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO492922.581e-6230.78Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of General transcription factor iih subunit 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
gtf2h13.883e-6136.18general transcription factor IIH subunit 1 [Source... [more]
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BLAST of General transcription factor iih subunit 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000055374.10.000e+099.65SMESG000055374.1[more]
SMESG000071924.14.948e-12639.65SMESG000071924.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30024480 ID=SMED30024480|Name=General transcription factor iih subunit 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1779bp
TTTAAAAGTTGTTATTAATAACTTTCATTATAAATATATTCAATATGTCA
AATGTTTCAAAATCTACGGAAGATATTGTAAAATTAATTGATCATGTCAG
TTATAAAAAGACAGAAGGAAAATTATATTTAATGACAGAGAGATTAGCTT
GGATGACAAATACTTCAGATGTGTTTAAAATTAGTGAACATTATAAAAAT
ATTCGTGCTCAAAGAATTAGTCCAGACGATAAAGATAAAGTTCAATTACA
ATTACTTATGCACTCTGGTTCTTCCTTTACTTTTCATTTCATTCATCCTG
ACGGAAGATCCAAGCAAGTAAGTGATCGAAATAACGTTAAAATTTCTCTC
CAATATTTCATTCCAAGATTTAAAGAAAAAGCTCAATCTGAACTGGAAAA
TAAAAGAAAACTTTGTGAAAATAATCCTCAGATCTTAGATTTATATCGTG
AATTAGTCACTAATAAATATATGTGTAAAGAAGAATTTTGGCAACGTGCT
GAGTCTAATATTAGCCAACAATCATCAGTTAATGAGTATAGCATGTACAA
TCGTGGTATTCCATCTTGGTTGCTAGCAACTCCTCCTCAAAAAGACGGAA
AATCACAGTGTAATCTCAGTCGGCAAATGGTTGAGGATATATTTGCAGTT
TATCCGGCAGTTAAACAAAAACATACTCAACTGGTTCCCAACGAAATGTC
TGAAGAAGAATTTTGGAACAAATTCTTTCAATCTCATTATTTCCATAGAT
TCAAAAGCGATCTTTCCAATGATAAATTTGGCAGTTGTGCATATTATGAC
ATTCAGCAAATCGAAAAAGAAGCCCAGCGATTAAAAAAGGAATCCTTGAT
ACTCATCCAGGATAAAACTGAAGATGTCGGGGAGTTTTGTGTTCCGGATA
ACACTGGGAAATCGGTTAATTCTGACACGCAAAAGAGTTCGAGCTCCGAA
GAACTTTTAAGACGATTCAATCGCCAGAGTTTCCTCATATTGAAAACAAT
GAAATCTAAAAATACATCAAAACGAGCAAACGATTCAGATTGCGTGGATT
TGGATAGCGGAAATGAGAAACGGCGATTGATTGATTCGTCATCGGAAATG
TACAGTGAAGAGGAACGATTCGTTTTGGAAAAATCGACATTCGATCGTTT
GGAAGGCGTGAAATTCAATACTGACAAAGTCAGTCAGTATATCAACCGGA
TCTCATCGAGCAACGTTGCCAACGTAACCAGTCAATCAACAGCCGACAGA
AAACGGTTAAAGCAGTTCCAGGATGAGCAATTGCGTAGATTGGCCGGGTT
GAAACAAAATCTCGCCCTCACGAGGTGTCGGCCACTCGTCAATTTGATGT
CGTCGTCAGTGGCAACGGACGTTTTAACAGATATAGGGCACCTGTTTTCT
GATGCTGATGTCGCGGTGTCCTCCTGTATTCAGCAGGGCCGGAATGCCGG
GAAACTTCCGCCGGAAATGATACGCGATATCAAATTGCTGTACCGGATAT
CATCGGAACTGTTCCGGCATTTCTGGGAATGTTTCCCGGTTACCGATTCC
GCCGGGTTCGAGAAGCTGCATCGGATGGTGGAGGCCATTAAAAAATTTCG
GTTGCAGAAAATCGACGGTTTCGTTCAGCAGCATCCGAATTATTACATTT
TGACCGGATCGATGGATTCGAAACCGATCGATCACTTGTGCAAAATGACA
GACCGGGTCAATGAGGCGTTTGAGCGCTACATGGCAAATTACAAACGCAT
TAATAAGGCGTAGCAGTGATTTACAGGTT
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protein sequence of SMED30024480-orf-1

>SMED30024480-orf-1 ID=SMED30024480-orf-1|Name=SMED30024480-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=573bp
MSNVSKSTEDIVKLIDHVSYKKTEGKLYLMTERLAWMTNTSDVFKISEHY
KNIRAQRISPDDKDKVQLQLLMHSGSSFTFHFIHPDGRSKQVSDRNNVKI
SLQYFIPRFKEKAQSELENKRKLCENNPQILDLYRELVTNKYMCKEEFWQ
RAESNISQQSSVNEYSMYNRGIPSWLLATPPQKDGKSQCNLSRQMVEDIF
AVYPAVKQKHTQLVPNEMSEEEFWNKFFQSHYFHRFKSDLSNDKFGSCAY
YDIQQIEKEAQRLKKESLILIQDKTEDVGEFCVPDNTGKSVNSDTQKSSS
SEELLRRFNRQSFLILKTMKSKNTSKRANDSDCVDLDSGNEKRRLIDSSS
EMYSEEERFVLEKSTFDRLEGVKFNTDKVSQYINRISSSNVANVTSQSTA
DRKRLKQFQDEQLRRLAGLKQNLALTRCRPLVNLMSSSVATDVLTDIGHL
FSDADVAVSSCIQQGRNAGKLPPEMIRDIKLLYRISSELFRHFWECFPVT
DSAGFEKLHRMVEAIKKFRLQKIDGFVQQHPNYYILTGSMDSKPIDHLCK
MTDRVNEAFERYMANYKRINKA*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR027079Tfb1/GTF2H1
IPR005607BSD_dom
IPR011993PH-like_dom_sf
IPR013876TFIIH_BTF_p62_N
Vocabulary: cellular component
TermDefinition
GO:0000439core TFIIH complex
Vocabulary: biological process
TermDefinition
GO:0006289nucleotide-excision repair
GO:0006351transcription, DNA-templated
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 253..273
NoneNo IPR availablePANTHERPTHR12856:SF0GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1coord: 8..567
NoneNo IPR availableCDDcd13229PH_TFIIHcoord: 14..108
e-value: 2.18597E-24
score: 95.4161
NoneNo IPR availableSUPERFAMILYSSF50729PH domain-likecoord: 5..113
NoneNo IPR availableSUPERFAMILYSSF140383BSD domain-likecoord: 190..236
NoneNo IPR availableSUPERFAMILYSSF140383BSD domain-likecoord: 110..151
IPR005607BSD domainSMARTSM00751wurzfinal6coord: 183..235
e-value: 5.4E-11
score: 52.5
coord: 105..160
e-value: 1.8
score: 7.0
IPR005607BSD domainPFAMPF03909BSDcoord: 191..235
e-value: 2.6E-11
score: 43.3
IPR005607BSD domainPROSITEPS50858BSDcoord: 183..235
score: 13.533
IPR011993PH-like domain superfamilyGENE3DG3DSA:2.30.29.30coord: 4..114
e-value: 1.9E-35
score: 122.9
IPR013876TFIIH p62 subunit, N-terminalPFAMPF08567PH_TFIIHcoord: 19..103
e-value: 4.2E-20
score: 71.9
IPR027079TFIIH subunit Tfb1/GTF2H1PANTHERPTHR12856TRANSCRIPTION INITIATION FACTOR IIH-RELATEDcoord: 8..567