receptor tyrosine kinase-1

Overview


Name	receptor tyrosine kinase-1 (AFJ24816.1)
Smed ID	SMED30024446
Length (bp)	3876

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of receptor tyrosine kinase-1 (SMED30024446) t-SNE clustered cells

Violin plots show distribution of expression levels for receptor tyrosine kinase-1 (SMED30024446) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of receptor tyrosine kinase-1 (SMED30024446) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for receptor tyrosine kinase-1 (SMED30024446) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30024446

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30024446	SMESG000025275.1	dd_Smed_v4_8651_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30024446	SMESG000025275.1	dd_Smed_v4_8651_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30024446	SMESG000025275.1	dd_Smed_v4_8651_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30024446	SMESG000025275.1	dd_Smed_v4_8651_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of receptor tyrosine kinase-1 vs. Ensembl Human
Match: INSR (insulin receptor [Source:HGNC Symbol;Acc:HGNC:6091])

HSP 1 Score: 182.956 bits (463), Expect = 6.864e-46
Identity = 103/281 (36.65%), Postives = 162/281 (57.65%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNA-HGMLEA-VAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSN 3372
            +G+G+FGMVY G A +   G  E  VA KT++ES++  E+I+F  EA VM+     ++V L+GV  + +  L+  +MELM  GDL++YL S R +A     N          +   A +IA+G+ Y++++  VHRD+A RNC+++HDF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ +    PYQ  S+ Q +  +  +    L   D  P+   D     L+  C  +    RP  +E I+ +LK +
Sbjct: 1029 LGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLV--VMELMAHGDLKSYLRSLRPEA---ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV--MDGGYLDQPDNCPERVTD-----LMRMCWQFNPKMRPTFLE-IVNLLKDD 1293

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Human
Match: INSR (insulin receptor [Source:HGNC Symbol;Acc:HGNC:6091])

HSP 1 Score: 182.956 bits (463), Expect = 7.775e-46
Identity = 103/281 (36.65%), Postives = 162/281 (57.65%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNA-HGMLEA-VAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSN 3372
            +G+G+FGMVY G A +   G  E  VA KT++ES++  E+I+F  EA VM+     ++V L+GV  + +  L+  +MELM  GDL++YL S R +A     N          +   A +IA+G+ Y++++  VHRD+A RNC+++HDF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ +    PYQ  S+ Q +  +  +    L   D  P+   D     L+  C  +    RP  +E I+ +LK +
Sbjct: 1017 LGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLV--VMELMAHGDLKSYLRSLRPEA---ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV--MDGGYLDQPDNCPERVTD-----LMRMCWQFNPKMRPTFLE-IVNLLKDD 1281

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Human
Match: IGF1R (insulin like growth factor 1 receptor [Source:HGNC Symbol;Acc:HGNC:5465])

HSP 1 Score: 176.792 bits (447), Expect = 5.415e-44
Identity = 101/280 (36.07%), Postives = 163/280 (58.21%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            +G+G+FGMVY G A    G+++      VA KT++E+++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S R +      N + +    +++   A +IA+G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  Y    RP  +E I  I
Sbjct: 1004 LGQGSFGMVYEGVA---KGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRPEM---ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV--MEGGLLDKPDNCPD-----MLFELMRMCWQYNPKMRPSFLEIISSI 1265

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Human
Match: IGF1R (insulin like growth factor 1 receptor [Source:HGNC Symbol;Acc:HGNC:5465])

HSP 1 Score: 176.792 bits (447), Expect = 5.804e-44
Identity = 101/280 (36.07%), Postives = 163/280 (58.21%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            +G+G+FGMVY G A    G+++      VA KT++E+++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S R +      N + +    +++   A +IA+G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  Y    RP  +E I  I
Sbjct: 1005 LGQGSFGMVYEGVA---KGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRPEM---ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV--MEGGLLDKPDNCPD-----MLFELMRMCWQYNPKMRPSFLEIISSI 1266

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Human
Match: FER (FER tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:3655])

HSP 1 Score: 165.622 bits (418), Expect = 1.712e-43
Identity = 93/273 (34.07%), Postives = 153/273 (56.04%), Query Frame = 1

Query: 2527 NHIIGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETME 3345
              ++G+G FG VY G   +      +VA KT  E      KI F  EAK++++  H NIV+LIGVC + +   +++IMEL+  GD   +L  RR K         + ++L+ +L  F+ D A G+ Y+ S+  +HRD+A RNCL+  +  +K+ DFG++R    +   G+Y   G   +P++W  PE + +G +S +SD+WSFGILL+E  + GVCPY   ++ Q  + ++R  R  +S   + P+      + +++ +C  Y   NRP+  E
Sbjct:  155 GELLGKGNFGEVYKGTLKDK----TSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQP--VYIIMELVSGGDFLTFL--RRKK---------DELKLK-QLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSR----QEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYR--MSAPQHCPED-----ISKIMMKCWDYKPENRPKFSE 398

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Celegans
Match: svh-2 (Tyrosine-protein kinase receptor svh-2 [Source:UniProtKB/Swiss-Prot;Acc:H2KZU7])

HSP 1 Score: 160.999 bits (406), Expect = 1.040e-39
Identity = 89/221 (40.27%), Postives = 132/221 (59.73%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKI-DFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSS 3195
            IG+G +G+VY      +  + E V  K + E      KI +F+ EA+ M +  H NI++LIGV L++ ++L  +I E M +GDL++++           EN   +I++R+ L  FA DIA+G+NYMHS+  +HRD+ACRNCL+     +K+ DFGL R +     T +Y       LPVRW PPE  + G F I SDIWSFG++++EL T G  PY + +S
Sbjct:  741 IGQGHYGVVYKAMYSPSKSLEEKVVCKYLKEG-----KISEFYEEARTMSEFDHPNILKLIGVALDDSSHLPIIITEYMAKGDLKSFI-----------ENVENTIKMRD-LFEFAFDIAKGMNYMHSKKFIHRDLACRNCLLDEHLRVKIADFGLCRKV--DIETELYVQMHERDLPVRWFPPEISEQG-FGITSDIWSFGVVIWELFTRGSTPYSNMAS 941

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Celegans
Match: svh-2 (Tyrosine-protein kinase receptor svh-2 [Source:UniProtKB/Swiss-Prot;Acc:H2KZU7])

HSP 1 Score: 160.614 bits (405), Expect = 1.228e-39
Identity = 89/221 (40.27%), Postives = 132/221 (59.73%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKI-DFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSS 3195
            IG+G +G+VY      +  + E V  K + E      KI +F+ EA+ M +  H NI++LIGV L++ ++L  +I E M +GDL++++           EN   +I++R+ L  FA DIA+G+NYMHS+  +HRD+ACRNCL+     +K+ DFGL R +     T +Y       LPVRW PPE  + G F I SDIWSFG++++EL T G  PY + +S
Sbjct:  741 IGQGHYGVVYKAMYSPSKSLEEKVVCKYLKEG-----KISEFYEEARTMSEFDHPNILKLIGVALDDSSHLPIIITEYMAKGDLKSFI-----------ENVENTIKMRD-LFEFAFDIAKGMNYMHSKKFIHRDLACRNCLLDEHLRVKIADFGLCRKV--DIETELYVQMHERDLPVRWFPPEISEQG-FGITSDIWSFGVVIWELFTRGSTPYSNMAS 941

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Celegans
Match: svh-2 (Tyrosine-protein kinase receptor svh-2 [Source:UniProtKB/Swiss-Prot;Acc:H2KZU7])

HSP 1 Score: 160.614 bits (405), Expect = 1.228e-39
Identity = 89/221 (40.27%), Postives = 132/221 (59.73%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKI-DFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSS 3195
            IG+G +G+VY      +  + E V  K + E      KI +F+ EA+ M +  H NI++LIGV L++ ++L  +I E M +GDL++++           EN   +I++R+ L  FA DIA+G+NYMHS+  +HRD+ACRNCL+     +K+ DFGL R +     T +Y       LPVRW PPE  + G F I SDIWSFG++++EL T G  PY + +S
Sbjct:  741 IGQGHYGVVYKAMYSPSKSLEEKVVCKYLKEG-----KISEFYEEARTMSEFDHPNILKLIGVALDDSSHLPIIITEYMAKGDLKSFI-----------ENVENTIKMRD-LFEFAFDIAKGMNYMHSKKFIHRDLACRNCLLDEHLRVKIADFGLCRKV--DIETELYVQMHERDLPVRWFPPEISEQG-FGITSDIWSFGVVIWELFTRGSTPYSNMAS 941

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Celegans
Match: svh-2 (Tyrosine-protein kinase receptor svh-2 [Source:UniProtKB/Swiss-Prot;Acc:H2KZU7])

HSP 1 Score: 160.614 bits (405), Expect = 1.397e-39
Identity = 89/221 (40.27%), Postives = 132/221 (59.73%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKI-DFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSS 3195
            IG+G +G+VY      +  + E V  K + E      KI +F+ EA+ M +  H NI++LIGV L++ ++L  +I E M +GDL++++           EN   +I++R+ L  FA DIA+G+NYMHS+  +HRD+ACRNCL+     +K+ DFGL R +     T +Y       LPVRW PPE  + G F I SDIWSFG++++EL T G  PY + +S
Sbjct:  741 IGQGHYGVVYKAMYSPSKSLEEKVVCKYLKEG-----KISEFYEEARTMSEFDHPNILKLIGVALDDSSHLPIIITEYMAKGDLKSFI-----------ENVENTIKMRD-LFEFAFDIAKGMNYMHSKKFIHRDLACRNCLLDEHLRVKIADFGLCRKV--DIETELYVQMHERDLPVRWFPPEISEQG-FGITSDIWSFGVVIWELFTRGSTPYSNMAS 941

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Celegans
Match: daf-2 (Insulin-like receptor Insulin-like receptor subunit alpha Insulin-like receptor subunit beta [Source:UniProtKB/Swiss-Prot;Acc:Q968Y9])

HSP 1 Score: 147.902 bits (372), Expect = 2.757e-36
Identity = 90/286 (31.47%), Postives = 155/286 (54.20%), Query Frame = 1

Query: 2539 GRGAFGMVYGGEALNAHGMLE----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIEL--RNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSNNS 3378
            G G+FG VY G   N   ++       A K   +     E +++  EA +M+  K + IV+L GV    +  ++  +ME+M  G+LR+YL S+R +  ++ E      ++  R++ + +A  I +G+ Y+ S    HRD+A RNC+I+ D  +K+GDFG+ R L        YK  G   +PVRWM PE ++ G F  KSD+WSFG++L+E+VT G  PY   S+++ ++ I   ++ +       P+  ++   ++++  C  Y   +RP T  Q++ +L +  S
Sbjct:   79 GEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLMEANIMKNFKTNFIVKLYGVISTVQPAMV--VMEMMDLGNLRDYLRSKR-EDEVFNETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYH---DYYKPSGKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKK-----PECCEN-YWYKVMKMCWRYSPRDRP-TFLQLVHLLAAEAS 351

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Fly
Match: InR (gene:FBgn0283499 transcript:FBtr0290232)

HSP 1 Score: 171.014 bits (432), Expect = 2.407e-42
Identity = 95/286 (33.22%), Postives = 167/286 (58.39%), Query Frame = 1

Query: 2536 IGRGAFGMVYGG--EALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELR------------NRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQI 3351
            +G+G+FGMVY G  ++   +G+    A KT++E++   E+ +F +EA VM++    ++V L+GVC   +  L+  +MELM +GDL++YL + R +    R+ ++ +   R             R+   A +IA+G+ Y+ ++  VHRD+A RNC+++ D  +K+GDFG+TR +     T  Y+      LPVRWMPPE ++ G++S  SD++SFG++L+E+ T    PYQ  S+ Q +  +  I   ++      P++  D  +H+L+ +C  + S+ RP  ++ I
Sbjct: 1377 LGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALV--VMELMKKGDLKSYLRAHRPEE---RDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIY---ETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYV--IDGGVME----RPENCPD-FLHKLMQRCWHHRSSARPSFLDII 1647

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Fly
Match: InR (gene:FBgn0283499 transcript:FBtr0290230)

HSP 1 Score: 171.014 bits (432), Expect = 2.407e-42
Identity = 95/286 (33.22%), Postives = 167/286 (58.39%), Query Frame = 1

Query: 2536 IGRGAFGMVYGG--EALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELR------------NRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQI 3351
            +G+G+FGMVY G  ++   +G+    A KT++E++   E+ +F +EA VM++    ++V L+GVC   +  L+  +MELM +GDL++YL + R +    R+ ++ +   R             R+   A +IA+G+ Y+ ++  VHRD+A RNC+++ D  +K+GDFG+TR +     T  Y+      LPVRWMPPE ++ G++S  SD++SFG++L+E+ T    PYQ  S+ Q +  +  I   ++      P++  D  +H+L+ +C  + S+ RP  ++ I
Sbjct: 1377 LGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALV--VMELMKKGDLKSYLRAHRPEE---RDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIY---ETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYV--IDGGVME----RPENCPD-FLHKLMQRCWHHRSSARPSFLDII 1647

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Fly
Match: InR (gene:FBgn0283499 transcript:FBtr0084121)

HSP 1 Score: 171.014 bits (432), Expect = 2.407e-42
Identity = 95/286 (33.22%), Postives = 167/286 (58.39%), Query Frame = 1

Query: 2536 IGRGAFGMVYGG--EALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELR------------NRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQI 3351
            +G+G+FGMVY G  ++   +G+    A KT++E++   E+ +F +EA VM++    ++V L+GVC   +  L+  +MELM +GDL++YL + R +    R+ ++ +   R             R+   A +IA+G+ Y+ ++  VHRD+A RNC+++ D  +K+GDFG+TR +     T  Y+      LPVRWMPPE ++ G++S  SD++SFG++L+E+ T    PYQ  S+ Q +  +  I   ++      P++  D  +H+L+ +C  + S+ RP  ++ I
Sbjct: 1377 LGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALV--VMELMKKGDLKSYLRAHRPEE---RDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIY---ETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYV--IDGGVME----RPENCPD-FLHKLMQRCWHHRSSARPSFLDII 1647

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Fly
Match: InR (gene:FBgn0283499 transcript:FBtr0290231)

HSP 1 Score: 171.014 bits (432), Expect = 2.407e-42
Identity = 95/286 (33.22%), Postives = 167/286 (58.39%), Query Frame = 1

Query: 2536 IGRGAFGMVYGG--EALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELR------------NRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQI 3351
            +G+G+FGMVY G  ++   +G+    A KT++E++   E+ +F +EA VM++    ++V L+GVC   +  L+  +MELM +GDL++YL + R +    R+ ++ +   R             R+   A +IA+G+ Y+ ++  VHRD+A RNC+++ D  +K+GDFG+TR +     T  Y+      LPVRWMPPE ++ G++S  SD++SFG++L+E+ T    PYQ  S+ Q +  +  I   ++      P++  D  +H+L+ +C  + S+ RP  ++ I
Sbjct: 1377 LGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALV--VMELMKKGDLKSYLRAHRPEE---RDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIY---ETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYV--IDGGVME----RPENCPD-FLHKLMQRCWHHRSSARPSFLDII 1647

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Fly
Match: Ror (gene:FBgn0010407 transcript:FBtr0079978)

HSP 1 Score: 164.851 bits (416), Expect = 1.319e-41
Identity = 96/266 (36.09%), Postives = 147/266 (55.26%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRP 3333
            +G GAFG VY G+ L  +     VA K + E+++   + DF  E +++  LKH NIV ++GV L  E     ++ E M  GDL  +L+S           SL  +E        A  I+EG+ Y+ +   VHRD+A RNCL++    +K+ DFGL+R +    S+  Y+ Q    LPVRWMP E I +G F+ +SD+WSFG++L+E+ ++G+ PY  FS+ + ++LI    R LLS  +  P     + V+ L+ +C    S  RP
Sbjct:  416 LGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCILGVVLNKEP--YCMLFEYMANGDLHEFLISNSPTEG----KSLSQLEFLQ----IALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIY---SSDYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIR--SRQLLSAPENCP-----TAVYSLMIECWHEQSVKRP 661

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Zebrafish
Match: igf1ra (insulin-like growth factor 1a receptor [Source:ZFIN;Acc:ZDB-GENE-020503-1])

HSP 1 Score: 182.185 bits (461), Expect = 6.069e-46
Identity = 104/280 (37.14%), Postives = 166/280 (59.29%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            +G+G+FGMVY G    A G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL+++L S RSK    + +S +S+    ++   A +IA+G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  Y    RP  +E I  I
Sbjct:  843 LGQGSFGMVYEG---IAKGVVKDEPETRVAIKTVNESASVRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSHLRSLRSKE---QGSSSQSLPPLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFV--MEGGLLDKPDNCP-----DMLFELMRMCWQYNPKMRPSFLEIINSI 1104

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Zebrafish
Match: igf1ra (insulin-like growth factor 1a receptor [Source:ZFIN;Acc:ZDB-GENE-020503-1])

HSP 1 Score: 182.185 bits (461), Expect = 6.404e-46
Identity = 104/280 (37.14%), Postives = 166/280 (59.29%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            +G+G+FGMVY G    A G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL+++L S RSK    + +S +S+    ++   A +IA+G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  Y    RP  +E I  I
Sbjct:  875 LGQGSFGMVYEG---IAKGVVKDEPETRVAIKTVNESASVRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSHLRSLRSKE---QGSSSQSLPPLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFV--MEGGLLDKPDNCP-----DMLFELMRMCWQYNPKMRPSFLEIINSI 1136

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Zebrafish
Match: igf1ra (insulin-like growth factor 1a receptor [Source:ZFIN;Acc:ZDB-GENE-020503-1])

HSP 1 Score: 182.185 bits (461), Expect = 7.156e-46
Identity = 104/280 (37.14%), Postives = 166/280 (59.29%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            +G+G+FGMVY G    A G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL+++L S RSK    + +S +S+    ++   A +IA+G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  Y    RP  +E I  I
Sbjct:  844 LGQGSFGMVYEG---IAKGVVKDEPETRVAIKTVNESASVRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSHLRSLRSKE---QGSSSQSLPPLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFV--MEGGLLDKPDNCP-----DMLFELMRMCWQYNPKMRPSFLEIINSI 1105

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Zebrafish
Match: igf1ra (insulin-like growth factor 1a receptor [Source:ZFIN;Acc:ZDB-GENE-020503-1])

HSP 1 Score: 181.8 bits (460), Expect = 8.225e-46
Identity = 104/280 (37.14%), Postives = 166/280 (59.29%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            +G+G+FGMVY G    A G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL+++L S RSK    + +S +S+    ++   A +IA+G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  Y    RP  +E I  I
Sbjct:  876 LGQGSFGMVYEG---IAKGVVKDEPETRVAIKTVNESASVRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSHLRSLRSKE---QGSSSQSLPPLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFV--MEGGLLDKPDNCP-----DMLFELMRMCWQYNPKMRPSFLEIINSI 1137

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Zebrafish
Match: igf1ra (insulin-like growth factor 1a receptor [Source:ZFIN;Acc:ZDB-GENE-020503-1])

HSP 1 Score: 182.185 bits (461), Expect = 9.093e-46
Identity = 104/280 (37.14%), Postives = 166/280 (59.29%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            +G+G+FGMVY G    A G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL+++L S RSK    + +S +S+    ++   A +IA+G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  Y    RP  +E I  I
Sbjct: 1003 LGQGSFGMVYEG---IAKGVVKDEPETRVAIKTVNESASVRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSHLRSLRSKE---QGSSSQSLPPLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFV--MEGGLLDKPDNCP-----DMLFELMRMCWQYNPKMRPSFLEIINSI 1264

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Xenopus
Match: IGF1R (insulin like growth factor 1 receptor [Source:NCBI gene;Acc:100329112])

HSP 1 Score: 180.259 bits (456), Expect = 4.273e-45
Identity = 104/283 (36.75%), Postives = 162/283 (57.24%), Query Frame = 1

Query: 2527 NHIIGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            N  +G+G+FGMVY G    A G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S R        NS +      ++   A +IA+G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  Y    RP  +E I  I
Sbjct:  958 NRELGQGSFGMVYEG---IAKGVVKDEAETRVAIKTVNESASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRPDT---ESNSGQPPPSLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFV--MEGGLLEKPDNCP-----DMLFELMRMCWQYNPKMRPSFLEIISSI 1222

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Xenopus
Match: IGF1R (insulin like growth factor 1 receptor [Source:NCBI gene;Acc:100329112])

HSP 1 Score: 180.259 bits (456), Expect = 4.534e-45
Identity = 104/283 (36.75%), Postives = 162/283 (57.24%), Query Frame = 1

Query: 2527 NHIIGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            N  +G+G+FGMVY G    A G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S R        NS +      ++   A +IA+G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  Y    RP  +E I  I
Sbjct:  980 NRELGQGSFGMVYEG---IAKGVVKDEAETRVAIKTVNESASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRPDT---ESNSGQPPPSLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFV--MEGGLLEKPDNCP-----DMLFELMRMCWQYNPKMRPSFLEIISSI 1244

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Xenopus
Match: IGF1R (insulin like growth factor 1 receptor [Source:NCBI gene;Acc:100329112])

HSP 1 Score: 180.259 bits (456), Expect = 4.685e-45
Identity = 104/283 (36.75%), Postives = 162/283 (57.24%), Query Frame = 1

Query: 2527 NHIIGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            N  +G+G+FGMVY G    A G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S R        NS +      ++   A +IA+G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  Y    RP  +E I  I
Sbjct:  956 NRELGQGSFGMVYEG---IAKGVVKDEAETRVAIKTVNESASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRPDT---ESNSGQPPPSLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFV--MEGGLLEKPDNCP-----DMLFELMRMCWQYNPKMRPSFLEIISSI 1220

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Xenopus
Match: IGF1R (insulin like growth factor 1 receptor [Source:NCBI gene;Acc:100329112])

HSP 1 Score: 180.259 bits (456), Expect = 4.762e-45
Identity = 104/283 (36.75%), Postives = 162/283 (57.24%), Query Frame = 1

Query: 2527 NHIIGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            N  +G+G+FGMVY G    A G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S R        NS +      ++   A +IA+G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  Y    RP  +E I  I
Sbjct: 1002 NRELGQGSFGMVYEG---IAKGVVKDEAETRVAIKTVNESASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRPDT---ESNSGQPPPSLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFV--MEGGLLEKPDNCP-----DMLFELMRMCWQYNPKMRPSFLEIISSI 1266

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Xenopus
Match: IGF1R (insulin like growth factor 1 receptor [Source:NCBI gene;Acc:100329112])

HSP 1 Score: 179.874 bits (455), Expect = 5.563e-45
Identity = 104/283 (36.75%), Postives = 162/283 (57.24%), Query Frame = 1

Query: 2527 NHIIGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            N  +G+G+FGMVY G    A G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S R        NS +      ++   A +IA+G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  Y    RP  +E I  I
Sbjct:  979 NRELGQGSFGMVYEG---IAKGVVKDEAETRVAIKTVNESASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRPDT---ESNSGQPPPSLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFV--MEGGLLEKPDNCP-----DMLFELMRMCWQYNPKMRPSFLEIISSI 1243

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Mouse
Match: Insr (insulin receptor [Source:MGI Symbol;Acc:MGI:96575])

HSP 1 Score: 178.333 bits (451), Expect = 1.484e-44
Identity = 101/281 (35.94%), Postives = 160/281 (56.94%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNA-HGMLEA-VAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSN 3372
            +G+G+FGMVY G A +   G  E  VA KT++ES++  E+I+F  EA VM+     ++V L+GV  + +  L+  +MELM  GDL+++L S R  A     N          +     +IA+G+ Y++++  VHRD+A RNC+++HDF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ +    PYQ  S+ Q +  +  +    L   D  P+   D     L+  C  +    RP  +E I+ +LK +
Sbjct: 1019 LGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLV--VMELMAHGDLKSHLRSLRPDA---ENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV--MDGGYLDPPDNCPERLTD-----LMRMCWQFNPKMRPTFLE-IVNLLKDD 1283

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BLAST of receptor tyrosine kinase-1 vs. Ensembl Mouse
Match: Igf1r (insulin-like growth factor I receptor [Source:MGI Symbol;Acc:MGI:96433])

HSP 1 Score: 177.948 bits (450), Expect = 1.598e-44
Identity = 104/284 (36.62%), Postives = 166/284 (58.45%), Query Frame = 1

Query: 2527 NHIIGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELR-NRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            N  +G+G+FGMVY G A    G+++      VA KT++E+++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S R +     +N+L  I    +++   A +IA+G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  Y    RP  +E I  I
Sbjct: 1003 NRELGQGSFGMVYEGVA---KGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRPEV---EQNNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV--MEGGLLDKPDNCPD-----MLFELMRMCWQYNPKMRPSFLEIIGSI 1268

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BLAST of receptor tyrosine kinase-1 vs. Ensembl Mouse
Match: Insrr (insulin receptor-related receptor [Source:MGI Symbol;Acc:MGI:1346037])

HSP 1 Score: 174.866 bits (442), Expect = 1.318e-43
Identity = 96/231 (41.56%), Postives = 144/231 (62.34%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEA--LNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYREN--SLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLI 3216
            +G+G+FGMVY G A  L A      VA KT++E ++  E+++F  EA VM+  K  ++V L+GV  + +  L+  IMELM  GDL+++L S R +A    EN   L    L + +   A +IA+G+ Y+ ++  VHRD+A RNC++S DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ GIF+  SD+WSFG++L+E+VT    PYQ  S+ Q +  +
Sbjct:  985 LGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSHLRSLRPEA----ENNPGLPQPALSDMIQ-MAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVY---ETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFV 1205

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Query: 2536 IGRGAFGMVYGGEA--LNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYREN--SLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLI 3216
            +G+G+FGMVY G A  L A      VA KT++E ++  E+++F  EA VM+  K  ++V L+GV  + +  L+  IMELM  GDL+++L S R +A    EN   L    L + +   A +IA+G+ Y+ ++  VHRD+A RNC++S DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ GIF+  SD+WSFG++L+E+VT    PYQ  S+ Q +  +
Sbjct:  985 LGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSHLRSLRPEA----ENNPGLPQPALSDMIQ-MAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVY---ETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFV 1205

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BLAST of receptor tyrosine kinase-1 vs. Ensembl Mouse
Match: Fer (fer (fms/fps related) protein kinase [Source:MGI Symbol;Acc:MGI:105917])

HSP 1 Score: 164.466 bits (415), Expect = 6.780e-43
Identity = 90/270 (33.33%), Postives = 146/270 (54.07%), Query Frame = 1

Query: 2527 NHIIGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPE 3336
              ++G+G FG VY G   +       VA KT  E      KI F  EAK++++  H NIV+LIGVC + +   +++IMEL+  GD   +L  R+ +  +             +L  F+ D+A G+ Y+ S+  +HRD+A RNCL+  +  +K+ DFG++R    +   G+Y   G   +P++W  PE + +G +S +SD+WSFGILL+E  + GVCPY   ++ Q  + ++R  R         PQ+  + V   ++ +C  Y   NRP+
Sbjct:  197 GELLGKGNFGEVYKGTLKDK----TPVAIKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQP--VYIIMELVPGGDFLTFLRKRKDELKL------------KQLVRFSLDVAAGMLYLESKNCIHRDLAARNCLVGENNTLKISDFGMSR----QEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRM------SAPQNCPEEVF-TIMMKCWDYKPENRPK 437

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BLAST of receptor tyrosine kinase-1 vs. UniProt/SwissProt
Match: sp|Q05688|IGF1R_BOVIN (Insulin-like growth factor 1 receptor (Fragment) OS=Bos taurus OX=9913 GN=IGF1R PE=2 SV=1)

HSP 1 Score: 178.718 bits (452), Expect = 2.234e-45
Identity = 100/280 (35.71%), Postives = 163/280 (58.21%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            +G+G+FGMVY G A    G+++      VA KT++E+++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S R +      N + +    +++   A +IA+G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  Y    RP  +E I  +
Sbjct:  278 LGQGSFGMVYEGVA---KGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRPE---MENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV--MEGGLLDKPDNCPD-----MLFELMRMCWQYNPKMRPSFLEIISSV 539

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BLAST of receptor tyrosine kinase-1 vs. UniProt/SwissProt
Match: sp|P06213|INSR_HUMAN (Insulin receptor OS=Homo sapiens OX=9606 GN=INSR PE=1 SV=4)

HSP 1 Score: 182.956 bits (463), Expect = 3.296e-45
Identity = 103/281 (36.65%), Postives = 162/281 (57.65%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNA-HGMLEA-VAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSN 3372
            +G+G+FGMVY G A +   G  E  VA KT++ES++  E+I+F  EA VM+     ++V L+GV  + +  L+  +MELM  GDL++YL S R +A     N          +   A +IA+G+ Y++++  VHRD+A RNC+++HDF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ +    PYQ  S+ Q +  +  +    L   D  P+   D     L+  C  +    RP  +E I+ +LK +
Sbjct: 1029 LGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLV--VMELMAHGDLKSYLRSLRPEA---ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV--MDGGYLDQPDNCPERVTD-----LMRMCWQFNPKMRPTFLE-IVNLLKDD 1293

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BLAST of receptor tyrosine kinase-1 vs. UniProt/SwissProt
Match: sp|P15127|INSR_RAT (Insulin receptor OS=Rattus norvegicus OX=10116 GN=Insr PE=1 SV=1)

HSP 1 Score: 179.104 bits (453), Expect = 5.200e-44
Identity = 101/281 (35.94%), Postives = 161/281 (57.30%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNA-HGMLEA-VAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSN 3372
            +G+G+FGMVY G A +   G +E  VA KT++ES++  E+I+F  EA VM+     ++V L+GV  + +  L+  +MELM  GDL+++L S R  A     N          +     +IA+G+ Y++++  VHRD+A RNC+++HDF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ +    PYQ  S+ Q +  +  +    L   D  P+   D     L+  C  +    RP  +E I+ +LK +
Sbjct: 1030 LGQGSFGMVYEGNAKDIIKGEVETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLV--VMELMAHGDLKSHLRSLRPDA---ENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV--MDGGYLDPPDNCPERLTD-----LMRMCWQFNPKMRPTFLE-IVNLLKDD 1294

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BLAST of receptor tyrosine kinase-1 vs. UniProt/SwissProt
Match: sp|P24062|IGF1R_RAT (Insulin-like growth factor 1 receptor OS=Rattus norvegicus OX=10116 GN=Igf1r PE=2 SV=2)

HSP 1 Score: 179.104 bits (453), Expect = 5.404e-44
Identity = 105/284 (36.97%), Postives = 166/284 (58.45%), Query Frame = 1

Query: 2527 NHIIGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELR-NRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            N  +G+G+FGMVY G A    G+++      VA KT++E+++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S R +     EN+L  I    +++   A +IA+G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  Y    RP  +E I  I
Sbjct: 1003 NRELGQGSFGMVYEGVA---KGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRPEV----ENNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV--MEGGLLDKPDNCPD-----MLFELMRMCWQYNPKMRPSFLEIIGSI 1267

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BLAST of receptor tyrosine kinase-1 vs. UniProt/SwissProt
Match: sp|O73798|IGF1R_XENLA (Insulin-like growth factor 1 receptor OS=Xenopus laevis OX=8355 GN=igf1r PE=1 SV=1)

HSP 1 Score: 179.104 bits (453), Expect = 5.916e-44
Identity = 102/283 (36.04%), Postives = 163/283 (57.60%), Query Frame = 1

Query: 2527 NHIIGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            N  +G+G+FGMVY G    A G+++      VA KT++E+++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S R        NS +      ++   A +IA+G++Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  +    RP  +E I  I
Sbjct:  998 NRELGQGSFGMVYEG---IAKGVVKDEAETKVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRPDT---ESNSGQPTPSLKKMIQMAGEIADGMSYLNANKFVHRDLAARNCMVTEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFV--MEGGLLEKPDNCPD-----MLFELMRMCWQFNPKMRPSFLEIISSI 1262

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BLAST of receptor tyrosine kinase-1 vs. TrEMBL
Match: I1ZIG2 (Receptor tyrosine kinase-1 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 706.827 bits (1823), Expect = 0.000e+0
Identity = 342/342 (100.00%), Postives = 342/342 (100.00%), Query Frame = 1

Query: 2824 YRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSNNSCIRPYLTEDPPKFEGDKNLDNLSMNLPGIVIEDDEVTFTSPSEMHLDSSQKRINIINRAFGIKSVSVKEKTDFPVRQLRPCQSSVFISRNQLSEENIDSMRMKKPLDIFVSSIPTDLCYNTGFPKKPRTSTRSMSNFLKISPKTSNFKLKILSKDFQ 3849
            YRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSNNSCIRPYLTEDPPKFEGDKNLDNLSMNLPGIVIEDDEVTFTSPSEMHLDSSQKRINIINRAFGIKSVSVKEKTDFPVRQLRPCQSSVFISRNQLSEENIDSMRMKKPLDIFVSSIPTDLCYNTGFPKKPRTSTRSMSNFLKISPKTSNFKLKILSKDFQ
Sbjct:   15 YRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSNNSCIRPYLTEDPPKFEGDKNLDNLSMNLPGIVIEDDEVTFTSPSEMHLDSSQKRINIINRAFGIKSVSVKEKTDFPVRQLRPCQSSVFISRNQLSEENIDSMRMKKPLDIFVSSIPTDLCYNTGFPKKPRTSTRSMSNFLKISPKTSNFKLKILSKDFQ 356

[Close]

BLAST of receptor tyrosine kinase-1 vs. TrEMBL
Match: R7US23 (Guanylate cyclase (Fragment) OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_136189 PE=4 SV=1)

HSP 1 Score: 336.65 bits (862), Expect = 5.927e-93
Identity = 313/1183 (26.46%), Postives = 529/1183 (44.72%), Query Frame = 1

Query:  268 ERLGY-KTSIRDA-DWDNVTAAISRLA-CNKKSCESSKPESHINMEIWMPAGFTNSEWVNRDLIIDCGPLGPIAKTGIFYFNH------ENKNYPLDDWR---------RLQETTRQNFPKTYHDKS-VFRHFMIFGNCN----DSTSSLCRTQFAID--------SKLPNRHAHVLNNLYK-------NWSIGSVLSDEFT--------KFYFTWYPNAITTQYKMSRILFPDCK-----YTDSNFPDSYCDDSINQLAKIVWFGIKTKAPLIYNLVDSFQLTQEDLVGFLK---EVNISSGNIEQEYFKIACNWVLNYKAAWKPFTV-GWNTTKELYIIILLPNTDSNISQDE-KNALKSALRYLNNNFSYFGSRQYKVLVKYTNVTCEQSDIIQEYLKLVSPASEEEHHHEVGIISGLSTYCMNEIYKLTNAQRKIMVSFRHEIYPILARHGKNQILNISYIYQTMPSKEAYYFILEKLITTYDWKYVTIITDTD----DYRSGLNASFIHKER--VYQNKKIDKALFDQFLR--QNIEKLSARIFLLDFNEADIFQILCTAGKLKMTLENGFVWIINRYFVNQSIINSFLWCKSEIE-SITSNYLYLSPYIKPAVECSDFYSNNLFRAV---------------KFLGKMVYFALKKNPSF-------FEFNSDILMNYS-RNVES-REYFCSGKLISH----------SPIKM---NENSFFWKVWSLYKINGSKTTTLFEFTLSEKFHILDTYEYKLKKIQ----SWNPPKDASLNEDCWVGSLTKILHVNC----VIAEMLVLMTISXXXXXXXXXXXXXXYKY--KTRKIYYPMKTVFHELVQXXXXXXXXXXXXXXNHII-----GRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKA--AIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSNNSCIRPYLTEDPPKFEGDKNLDNLSMNLP 3459
            E LGY K  IR   +  N T A++R++ C+  +  +  P+  IN+E+W PAGF    W+ RDL++D GPLGP  + G F            +++ +D WR         R     R N+ + +  K   F     +  CN    D    L       D        S  P R   +   +         +W IG  L    T          +F W PN +T     +RI FP CK       D+  P   CD  +NQL+K +W  +KT  P  Y+++ S + TQE+    L+   E+N    +    Y + AC WV + +  W  +     ++  ++Y+  + P T     Q       K A+  +N++ +    + Y++++   +  C+   ++++++  V    E E H  VGI+    +     I  ++     I+VS+  E   +  R    +I  +   ++TMP    +  +  ++    +W  V ++ +      +Y+S L   F+  +    Y  K   +  F++  +  + I  ++ARI +L   E     ++C A  +KMT + GFVW +  +F          W    I+ S+       S  ++ AV+C    +   F  +               +++G++    L  + SF       F    D L+     ++ES R    +  L++H           P++    N NS         KIN      L++   +E      T   KL   Q    S   P D S  + C + +   +L V+C    V+A ++ +      +L  FI +  +  +Y  K R     M+ +   L+ +   + +D  ++  +H++     G GAFG VYGGEAL     + AVA KT+   S+  EK+DF  EA++M++ +H NIV+L+GVC   E    + IMELM+ GDL+ YLLSRR     AI   + +       RL   A D A+GL Y+     +HRD+ACRNCL+     IK+GDFG+TR   P   +  Y+F     LPVRWM PE +  G+F+  SDIWS+G+LL+E++TFG  PYQ  S+ Q ++ +     N +S+      +    ++  ++  C ++ +++RP+ ++ I+ + + N   ++P L + P          +L M++P
Sbjct:   39 EVLGYEKVEIRSGFNSINSTEALNRISHCDGCNASTFIPDVMINLEVWSPAGFNMEPWIMRDLLVDAGPLGPTGRFGWFVPTEIVEQTWLTEHHVIDHWRALTVDHVTDRFTLEDRMNYIRNHLSKPRSFESEETYCKCNRGILDENGCLGNHLPGGDVENCALLLSSYPGRCDQLREQIMSLNLDVAVSW-IGPHLPKFITDRTERHEPTLFFNWIPNTLTATGNYTRIYFPSCKTGGVVLNDAGGPAGGCDFEVNQLSKFIWVRMKTHTPEAYHVITSMEFTQEEYEKLLRLNLELNPKYVDNSTYYDETACAWVKSNREKWTQWMPQNLSSKTKIYLGGMFPETGPYWRQPGIAPGAKMAVEAVNSDENIL--QDYEIVLLQKDTQCKADLVMKQFIYYV----ENETHPVVGILGPGCSETAAPIAGVSKHYNTIIVSYGAESLQLANR----EIFPL--FFRTMPPNTQFGSVYIEIFKRLEWTQVALLAEHGQEFPEYQSFLKDKFLSNKMSVAYDRKMPRQVTFEEAKKFLEEIADINARIIILTSYEKAARAVICQAYLMKMTPKQGFVWFLPAWFTRN------WWDTDNIQRSVKEEVPCSSQQMRQAVDCHFVLNIMHFGPLNQRIVGNMTVDEWLKRYMGRVSEQDLSFHASFAYDAVWVFALGLDKLLTADPSSLESIRTDRTTASLMTHLNNTQFDGASGPVRFTGANRNSIIEITQYSIKINDGIPIGLYQPNKNE------TERLKLNISQIIWPSGEKPVDGSEVKQCSIEAFRALLGVSCDRAIVVANVIGISAFGLCMLACFIVVEKLSCRYDRKVRDTRERMEEL--GLMAEPAWLSLDQWEVARDHVVLNRKLGEGAFGTVYGGEALIEEAWV-AVAVKTLKIGSSTEEKMDFLGEAEMMKRFEHENIVKLLGVCTRGEP--AYTIMELMLHGDLKTYLLSRRQMVGQAIPESDDITP----ERLTLMALDAAKGLKYLSDLKYIHRDLACRNCLVHVTKRIKIGDFGMTR---PMYDSDYYRFNKRGMLPVRWMAPESLTLGMFTPHSDIWSYGVLLYEIMTFGSFPYQGLSNKQVLEFVK--VGNTISV-----PAGCSELLGDVLKACWAFTADSRPD-IQDIVDLFEDNPCLLKPCL-DAPSAAVAIDTTGDLEMDMP 1175

[Close]

BLAST of receptor tyrosine kinase-1 vs. TrEMBL
Match: A0A2H1CG47 (Guanylate cyclase OS=Fasciola hepatica OX=6192 GN=D915_06263 PE=3 SV=1)

HSP 1 Score: 328.176 bits (840), Expect = 1.039e-90
Identity = 179/384 (46.61%), Postives = 254/384 (66.15%), Query Frame = 1

Query: 2269 NPPKDASL-NEDCWVGSLTKILHVNCVIAEMLVLMTISXXXXXXXXXXXXXXYKYKTRKIYYPMKTVFHELVQXXXXXXXXXXXXXXNHIIGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELR-NRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSNNSCIRPYLTEDPPK 3414
            +PP D S  NE C +  L+  L + C  A + V + +     +  I + L  Y+ K R+     +  F EL  +L D+DI   +++LN  IG+GAFG+V+GGEA   +G  EAVA K  +  + +  K DF +EAK+MR LKH N+V LIGV L +++NL +LIMELM+ GDL+ YLLSRR    I+ + S E  ++R + L S + DIA+G++Y+HS+ + HRDIACRNCL+  D  +K+GDFGLTR      + G YKF  N  LP+RWM PE +QFGIFS++SDIWS+GI L+E++TFGV PY D     +V++++R+KR   SI ++LP +A D+VV  LI QCC +   +RP +MEQ++  LKS+  CIRP+LT+DPPK
Sbjct:  416 HPPHDGSATNEVCALYFLSDTLRMGCTGATVFVAVMVCAVFFIPVILLSLH-YRRKLREAEQLTRKPFEELCAELADLDIPPDRIVLNRQIGQGAFGLVFGGEA-KTNGKWEAVAVKVTNVKATYEGKTDFLSEAKLMRSLKHGNVVRLIGVSLGSKDNL-YLIMELMLLGDLKTYLLSRR----IFAQRSPEHEDIRPSTLTSMSIDIAQGVSYLHSKHLRHRDIACRNCLVGSDHVVKIGDFGLTREAAKNSAEGYYKFTRNCELPIRWMSPEALQFGIFSVQSDIWSYGITLYEIITFGVFPYNDM---DDVEVVERVKRRECSITEFLPHTAVDTVVWHLIRQCCQHDWKSRPSSMEQVLDTLKSHPECIRPFLTDDPPK 789

[Close]

BLAST of receptor tyrosine kinase-1 vs. TrEMBL
Match: A0A0V0J4S3 (Guanylate cyclase OS=Schistocephalus solidus OX=70667 GN=TR114599 PE=3 SV=1)

HSP 1 Score: 331.643 bits (849), Expect = 1.658e-89
Identity = 171/389 (43.96%), Postives = 260/389 (66.84%), Query Frame = 1

Query: 2266 WNP----PKDASLNE-DCWVGSLTKILHVNCVIAEMLVLMTISXXXXXXXXXXXXXXYKYKTRKIYYPMKTVFHELVQXXXXXXXXXXXXXXNHIIGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELR-NRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSNNSCIRPYLTEDPPK 3414
            W P    P D ++ + DC  G L++ L V CV+A  +    +    LL    +++IFY+ K ++     +  + +L  +L DI++ S+ ++LN  +G+GAFG+VYGGEA    G  EAVA K I+  + +  K+DF +EAK+MR L H N+V L+G+CL  + N I+L+MELM+ GDL+ YLL+RR    +  ++  +  ++R + L + A DIAEG+ Y+H++ ++HRDIACRNCL+  D  +K+GDFGLTR        G Y+F  N  LP+RWM PE +QFGIFS+KSD+WS+GI+L+E++TFGV PY+      +V++++R+KR   SI D+LP +AKD+ V RLI  CC ++  +RPE+M Q+I+ L++N  CIRP+LT++PPK
Sbjct:  941 WYPNGVRPGDGTITDADCAFGFLSRWLGVGCVVATWIFSAVMVACGLLPIFLLVVIFYRRKLKEAENLTRKPYEDLCAELADINMPSTDIVLNRRVGQGAFGLVYGGEAKRL-GRWEAVAVKVITNKTTYEGKMDFLSEAKLMRGLDHKNVVRLVGICLHQQENDIYLVMELMLLGDLKTYLLARR----VLAQSDPDHEDIRPSTLTNMAIDIAEGMAYLHNKRLIHRDIACRNCLVGRDRVVKIGDFGLTREAKSNSPDGYYRFTRNCELPIRWMSPEAVQFGIFSVKSDLWSYGIVLYEMITFGVFPYEGLC---DVEVVERVKRMEFSITDFLPIAAKDTPVWRLIDSCCQHHWQHRPESMNQVIEALRANKDCIRPFLTDEPPK 1321

HSP 2 Score: 180.644 bits (457), Expect = 8.175e-42
Identity = 148/585 (25.30%), Postives = 255/585 (43.59%), Query Frame = 1

Query:  268 ERLGY-KTSIRDADWDNVTAAISRLACNKKSCESSKPESHINMEIWMPAGFTNSEWVNRDLIIDCGPLGPIAKTGIFYFNHENKNYPLDDWRRLQETTRQNFPKT--------YHDKSVFRHFMIFGNCN-----DSTSSLCRTQFAIDSKLPNRHAHVLNNLYKNWSIGSVLSDEFTKFYFT--------------------WYPNAITTQYKMSRILFPDC---------KYTDSNFPDSYCDDSINQLAKIVWFGIKTKAPLIYNLVDSFQLTQEDLVGFLKEV-----NISSGNIEQE-------YFKIACNWVLNYKAAWKPFTVGWNTTKELYIIILLPNTDS-NISQDEKNALKSALRYLNNNFSYFGSRQYKVLVKYTNVTCEQSDIIQEYLKLVSPASEEEHHHEVGIISGLSTYCMNEIYKLTNAQRKIMVSFRHEIYPILARHGKNQILNISYIYQTMPSKEAYYFILEKLITTYDWKYVTIITDTDDY--RSGLNASFIHKERVYQNKKIDKALFDQFLRQ----NIEKLSARIFLLDFNEADIFQILCTAGKLKMTLENGFVWIINRYFVNQ 1836
            ERLGY K     ++W++    +SR+ C K       P  H+N+E+W+  G   + + +   +   GPLGPI ++G+F      K++P      +Q  T+     T         +         I GN N     D   +L R    +DS        V ++   +  IG  L  E +   ++                    WYP+ +T   ++ R+  PDC            D +  +  C   +NQL KI W  +   APLI  LV+  Q+ Q D V  L++V     N ++     E       Y  IAC W+   +  WK +T GW+  KEL I  +        +S  EKNA+ SAL  LN N +YF   +Y V ++  NVTC Q  ++ ++ + +  A  +     VG+I+GL +  +  + +L N ++ I++S   E    L     N      Y ++T+PS     FIL +L   + W+ + +    D +  R    A+ I   ++  + ++++A       Q     +++ + RI ++++  +    ILC A  L+M+ + G+VW +N +  ++
Sbjct:   78 ERLGYNKIRFVHSNWESTAETVSRVNCAKHGTCQRPPPVHVNLEVWLAPGENIASYASPSHVSYHGPLGPITRSGLFVQADPLKDWPSAGHEIIQRQTQNPLTHTNDISQAASTNQSQAAPGTRIKGNYNVRLLYDYEDALKRLNALLDSD--GSRLAVQSDFRTSDDIGRFLRKEESSVRWSSARGSNGTSVPQQQQFVLLNWYPSPLTLNDQLVRVGLPDCISLRARNLRAQGDGSEHNQLCHFEVNQLVKIAWAKLGEAAPLIAKLVERMQILQSDYVQLLEDVDNNFLNYTAARQRGEERRFRAMYRDIACFWLRMNRPTWKEWTPGWDVKKELVIGGMFTFYGKWVLSGLEKNAV-SALDVLNGNPAYFADSEYVVKLQIRNVTCSQDVVLDDFYRFL--AERDNSETMVGLIAGLCSDSIEAMVELANIRKVIVISPTVESARFLVHRQFN------YFFRTVPSMSTASFILIRLFRLWGWRRIAMFRKDDHFFDRKAFEANDI---KIVGDFEVEEAALTYTSAQKNLMTLKQNNGRIVIVEYFASATAIILCAAYHLEMSHKTGYVWFLNPWLSDK 648

[Close]

BLAST of receptor tyrosine kinase-1 vs. TrEMBL
Match: Q8WSM2 (Guanylate cyclase OS=Schistosoma mansoni OX=6183 PE=2 SV=1)

HSP 1 Score: 329.331 bits (843), Expect = 4.696e-89
Identity = 179/419 (42.72%), Postives = 266/419 (63.48%), Query Frame = 1

Query: 2269 NPPKDAS-LNEDCWVGSLTKILHVNCVIAEMLVLMTISXXXXXXXXXXXXXXYKYKTRKIYYPMKTVFHELVQXXXXXXXXXXXXXXNHIIGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSNNSCIRPYLTEDPPKFEGDKNLDNLSMNLPGIVIEDDEVTFTS--PSEMHL 3516
             PP D S  ++DC  G +++I  VNC  + ++  ++I  F+ ++   + +++Y+ K +K    ++  +  L  +L DIDI  + ++LN  +G+GAFGMVYGGEA   +G  EAVA K I   S +  K DF +EAK+MR L H N+V L+G+CL  + N ++LIME M+ GDL+ YLLSRR  A    ++          L   A DIAEGL Y+H + ++HRDIACRNCL+  D  +K+GDFGLTR +    + G Y+F  N  LP+RWM PE +QFGIFS+ SDIWS+GI+L+E++TFGV PY   S   +V++++R+KR   SII +LP +A+++ + RLI QCC +   +RP +++QII IL+ N  C+RP LT +PPK   +  +D L  NL  + +   ++ F S  PS  +L
Sbjct:  912 GPPDDGSEHDDDCVFGFVSRIFGVNCTGSTVIATISIVVFVTVLCFILFIVYYRRKLKKTQLKIRQPYENLCNELKDIDIPPADIVLNRRVGQGAFGMVYGGEA-KRNGRWEAVAVKVIGNKSTYEGKTDFLSEAKLMRSLDHRNVVRLVGICLYPKENHLYLIMEFMLNGDLKTYLLSRRVLAQQVPDHDGVCPAT---LTGMAIDIAEGLAYLHRKNLIHRDIACRNCLVGSDGIVKIGDFGLTREMNSSENEGYYRFTRNCELPIRWMSPEAVQFGIFSVHSDIWSYGIVLYEIITFGVFPYDGLS---DVEIVERVKRKDFSIIQFLPLAARNTTISRLIYQCCQHQWQHRPASLDQIIAILRKNPDCVRPSLTNEPPK--PNSTIDALVFNLVLVHVSCRKILFASGDPSPSNL 1321

HSP 2 Score: 166.007 bits (419), Expect = 1.955e-37
Identity = 141/573 (24.61%), Postives = 237/573 (41.36%), Query Frame = 1

Query:  268 ERLGYK-TSIRDADWDNVTAAISRLACNKKSCESSKPESHINMEIWMPAGFTNSEWVNRDLIIDCGPLGPIAKTGIFYFNHENKNYPLDDWRRLQETTRQNFPKTYHDKSVFRHFMIFGNCNDSTSSLCRTQFAIDSKLPNRHAHVLNNLYKNWSIGS-VLSDEFTKF-----------YFTWYPN---------------------------AITTQYKMSRILFPDCKYTDSNFPDSYCDDSINQLAKIVWFGIKTKAPLIYNLVDSFQLTQEDLVGFLKEVNI----SSGNIEQEYFKIACNWVLNYKAAWKPFTVGWNTTKELYIIILLPNTDSNISQDEKNALKSALRYLNNNFSYFGSRQYKVLVKYTNVTCEQSDIIQEYLKLVSPASEEEHHHEVGIISGLSTYCMNEIYKLTNAQRKIMVSFRHEIYPILARHGKNQILNISYIYQTMPSKEAYYFILEKLITTYDWKYVTIITDTDDY-------RSGLN--ASFIHKERVYQNKKIDKALFDQFLRQNIEKLSARIFLLDFNEADIFQILCTAGKLKMTLENGFVWIINRYF 1827
            ERLGY+       D D+ T AISRL C   +C    P+ HIN+E+W+  G   S WV  + +ID GPLGP  +  I      ++   +     L ET          DK    H  I          L +T    +  L   +A    N +  +  GS +LS EF  F              WYP+                           A+   Y  SR       +  ++   S+C     Q  K+ W  +K+  PLIY LVD    +Q +    LK  N     S  ++  +Y  IAC W+      W  +T GWN    L +  L       +  +  +  + A+ ++N+N  YF + +Y + +   N+TC Q  ++ +Y  L++ +   +    +G+I+ L +  +  + ++ N +R+I+VS   E      R+         Y ++T+PS      IL +L +++ W+ V +    D +        +G++  A F+ KE       + +AL      + +   ++RIF++++       ILC A  L M  + G+VW +N + 
Sbjct:   78 ERLGYQFIEFVKQDTDHPTLAISRLDCKDSNCYK-LPDVHINLELWLSLGTITSSWVPHNRVIDNGPLGPTNRWAI-----SSREEFMSQVSALTETQ-----SDCRDKHRPTHSQI---------PLSQTAVQSECDLDICYASEFRNEFIRYFTGSEILSKEFAHFPNLHSSSPVMSIINWYPHGLGSFPLPSGLHFLGKKNHLNSTVIKTALDKIYHCSRQYSGTLSHIQNSKKSSFCQFESQQATKLSWAKLKSTVPLIYQLVDRMHFSQSEYEDLLKSANHLDPNSGQDLRSQYRDIACKWLRLSPTRWVSWTKGWNKKLNLTVAGLFAFYGKWVVSNLDHVAEQAINFVNHNPDYFSNTEYALTLDVRNLTCSQDVVLNDYFDLLTASKNRK---IIGVIAALCSDSIEPVVEVANMRRQIVVSPTVESVRFAKRY------QYPYFFRTVPSMTHVSLILIRLFSSWGWRRVAVFRGDDHFFDPLIFQSNGIDLIADFVMKENQLTYVTVLQAL------KLMNDRTSRIFMVEYFAKGTAIILCAAYHLGMHFDAGYVWFLNPWL 615

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Cavefish
Match: igf1ra (insulin-like growth factor 1 receptor [Source:NCBI gene;Acc:103037538])

HSP 1 Score: 182.57 bits (462), Expect = 5.250e-46
Identity = 104/280 (37.14%), Postives = 164/280 (58.57%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            +G+G+FGMVY G    A G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S RSK        L S++   ++   A +I++G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  Y    RP  +E I  I
Sbjct:  998 LGQGSFGMVYEG---IAKGVVKDEPETKVAIKTVNESASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRSKQQGSCSQPLPSLK---KMIQMAGEISDGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFV--MEGGLLDKPDNCPD-----MLFELMRMCWQYNPKMRPSFLEIISSI 1259

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Cavefish
Match: igf1rb (insulin-like growth factor 1 receptor [Source:NCBI gene;Acc:103045439])

HSP 1 Score: 180.259 bits (456), Expect = 2.644e-45
Identity = 105/280 (37.50%), Postives = 166/280 (59.29%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQI 3360
            +G+G+FGMVY G    A G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL + RSK +    +SL    L+ ++   A +IA+G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P      ++  L+  C  Y    RP  +E I  I
Sbjct: 1000 LGQGSFGMVYEG---IAKGVVKDEPETRVAIKTVNESASMHERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRTLRSKEST---SSLPLPPLK-KMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTMSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFV--MEGGLLDKPDNCPD-----MLFELMRMCWQYNPKMRPSFLEIISSI 1260

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Cavefish
Match: igf1ra (insulin-like growth factor 1 receptor [Source:NCBI gene;Acc:103037538])

HSP 1 Score: 179.489 bits (454), Expect = 4.094e-45
Identity = 100/262 (38.17%), Postives = 156/262 (59.54%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQC 3306
            +G+G+FGMVY G    A G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S RSK        L S++   ++   A +I++G+ Y+++   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL   D  P       V R   QC
Sbjct:  998 LGQGSFGMVYEG---IAKGVVKDEPETKVAIKTVNESASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRSKQQGSCSQPLPSLK---KMIQMAGEISDGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFV--MEGGLLDKPDNCPDMLCRYYVSRCAWQC 1246

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Cavefish
Match: insrb (insulin receptor b [Source:ZFIN;Acc:ZDB-GENE-020503-4])

HSP 1 Score: 177.178 bits (448), Expect = 2.018e-44
Identity = 104/281 (37.01%), Postives = 162/281 (57.65%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALN-AHGMLEA-VAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSN 3372
            +G+G+FGMVY G A +   G  E  VA KT++ES++  E+I+F  EA VM+     ++V L+GV  + +  L+  +MELM  GDL++YL S R  A     N          +   A +IA+G+ Y++++  VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD WSFG++L+E+ T    PYQ  S+ Q +  +  +    L      P+S  +  ++ L+  C  Y    RP T  +II++LK +
Sbjct:  897 LGQGSFGMVYEGIAKDIVKGEPETRVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLGVVSKGQPTLV--VMELMTHGDLKSYLRSLRPDA---ENNPGRPPPTLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDGWSFGVVLWEISTLAEQPYQGLSNEQVLKFV--MDGGYLD----RPESCAER-INNLMQMCWQYNPKMRP-TFNEIIEMLKDD 1161

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BLAST of receptor tyrosine kinase-1 vs. Ensembl Cavefish
Match: insra (insulin receptor [Source:NCBI gene;Acc:103039445])

HSP 1 Score: 176.792 bits (447), Expect = 2.893e-44
Identity = 102/279 (36.56%), Postives = 161/279 (57.71%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALN-AHGMLEA-VAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILK 3366
            +G+G+FGMVY G A +   G  +  VA KT++ES++  E+I+F  EA VM+     ++V L+GV  + +  L+  +MELM  GDL++YL   R ++     N          +   A +IA+G+ Y++++  VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD WSFG++L+E+ T    PYQ  S+ Q +  +  +    L      P +  D  +H L+  C  Y    RP T ++II++LK
Sbjct:  956 LGQGSFGMVYEGIAKDIVKGEPQTHVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLGVVSKGQPTLV--VMELMTHGDLKSYLRCLRPES---ENNPGRPPPTLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLAEQPYQGLSNEQVLKFV--MDGGYLD----RPDNCADR-LHNLMQMCWHYNPKMRP-TFQEIIEMLK 1218

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BLAST of receptor tyrosine kinase-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009485.1 (pep scaffold:Pmarinus_7.0:GL477866:1219:4704:1 gene:ENSPMAG00000008570.1 transcript:ENSPMAT00000009485.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 176.022 bits (445), Expect = 4.335e-49
Identity = 102/281 (36.30%), Postives = 159/281 (56.58%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLEA-----VAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYREN-SLESIELRN-----RLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETME 3345
            +G+G FGMVY G    A G+++      VA KT++E++   E+ +F  EA VM+     ++V L+GV   ++   I +IMELM  GDL++YL S R  A  + E   LE    R       +   A +IA+G+ Y++++  VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  +   LL +    P+  ++     LI +C  Y    RP  +E
Sbjct:   19 LGQGTFGMVYEG---LARGIVKGEDETRVAIKTVNETATMRERYEFLNEASVMKSFNCHHVVRLLGVV--SQAQPILVIMELMTRGDLKSYLRSLRPDAEDFTETIVLEKKPTRPPSSLPEMLQMAGEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATQAEQPYQGLSNEQVLKFV--MDGGLLVLPPACPERLQE-----LIRKCWQYNPRMRPTFLE 284

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BLAST of receptor tyrosine kinase-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009481.1 (pep scaffold:Pmarinus_7.0:GL477866:614:5163:1 gene:ENSPMAG00000008570.1 transcript:ENSPMAT00000009481.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 175.252 bits (443), Expect = 5.439e-47
Identity = 99/275 (36.00%), Postives = 155/275 (56.36%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLEA-----VAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETME 3345
            +G+G FGMVY G    A G+++      VA KT++E++   E+ +F  EA VM+     ++V L+GV   ++   I +IMELM  GDL++YL S R  A         S+     +   A +IA+G+ Y++++  VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  +   LL +    P+      +  LI +C  Y    RP  +E
Sbjct:   67 LGQGTFGMVYEG---LARGIVKGEDETRVAIKTVNETATMRERYEFLNEASVMKSFNCHHVVRLLGVV--SQAQPILVIMELMTRGDLKSYLRSLRPDAEKKPTRPPSSLP---EMLQMAGEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATQAEQPYQGLSNEQVLKFV--MDGGLLVLPPACPER-----LQELIRKCWQYNPRMRPTFLE 323

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BLAST of receptor tyrosine kinase-1 vs. Ensembl Sea Lamprey
Match: NTRK2 (neurotrophic receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:8032])

HSP 1 Score: 156.762 bits (395), Expect = 6.710e-42
Identity = 86/231 (37.23%), Postives = 132/231 (57.14%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGE--ALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIEL--RNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLI 3216
            +G GAFG VY  E  +L+       VAAKT+ + S+   K DF+ EA+++  L+H +IV   GVC+E E   + ++ E M  GDL  +L  R   A    +       L  + ++ +    IA G+ Y+ SQ  VHRD+A RNCL+     +K+GDFG++R +    ST  Y+  G+  LP+RWMPPE I +  F+  SD+WS G++L+E+ T+G  P+   S+ + +D I
Sbjct:   82 LGEGAFGKVYLAECSSLDVGQEPMLVAAKTLKDLSDGARK-DFYREAELLTNLQHEHIVRFYGVCVEGEP--LIMVFEYMKNGDLNKFLRLRGPDAVFMGDAPQAEPRLLSQAQMLNMGSQIAAGMAYLASQHFVHRDLATRNCLVGAGLVVKIGDFGMSRDVY---STDYYRVGGHTMLPIRWMPPESIMYRKFTADSDVWSLGVVLWEIFTYGKQPWYQLSNTEVIDCI 306

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BLAST of receptor tyrosine kinase-1 vs. Ensembl Sea Lamprey
Match: ltk (leukocyte receptor tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-030616-115])

HSP 1 Score: 164.466 bits (415), Expect = 9.574e-42
Identity = 107/307 (34.85%), Postives = 160/307 (52.12%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKA--AIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISH---DFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPE---TMEQIIQILKSNNSCIRPYLTE--DPPKFEGD 3426
            +G GAFG VY G           VA KT+ E  +  +++DF  EA ++ K  H NIV  +GV L+      F+++ELM  GD++ YL   R +A  A  R++ L+       L + A+DIA G  Y+     +HRDIA RNCL++    D   K+GDFG+ R +  R S   Y+  G   LPV+WMPPE    GIF+ K+D WSFG+LL+E+ + G  PY   S+ + ++ +    R     +D  P       V+R+++QC  +   +RP     +E+I    +  +    P  TE   PP  EG+
Sbjct:  459 LGHGAFGEVYEGRVTGIEPSPLKVAVKTLPEICSEQDELDFLMEALIISKFNHHNIVRCVGVSLQTLPR--FILLELMAGGDMKTYLREERPRAVCAGPRKSMLD-------LLTMAKDIACG-QYLEDNHFIHRDIAARNCLLTSKGSDRIAKIGDFGMARDIYSRAS--YYRKGGRAMLPVKWMPPEAFLEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVMEFVTSGGR-----MD--PPKNCPVPVYRIMTQCWQHRPEDRPNFSTILERITYCTQDPDVVQTPLPTEYMPPPDDEGN 746

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BLAST of receptor tyrosine kinase-1 vs. Ensembl Sea Lamprey
Match: frk (fyn-related Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-110411-7])

HSP 1 Score: 149.443 bits (376), Expect = 1.693e-38
Identity = 85/232 (36.64%), Postives = 132/232 (56.90%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKR 3231
            +G G FG V+ G   N+      VA KT+   +  ++K +F  EA++M++L+H+N+++L  VC + E   I++I ELM  G L +YL     K        L++ EL +     AR IA G+ Y+ SQ  +HRD+A RN L+      K+ DFGL R +  R     Y+ +    +P++W  PE + F  FS+KSD+WSFGILL+EL+T+G  PY +  + + +  +DR  R
Sbjct:  195 LGAGMFGEVWQGLWNNS----TLVAVKTLKPGA--MKKEEFIGEAQIMKQLRHANLIQLYAVCSQEEP--IYIITELMRHGSLLDYLRGPLGK-------QLKAPELVD----MARQIAAGMAYLESQNYIHRDLAARNILVGEGKVCKVADFGLARIIKVRYEDE-YEGKAGAKVPIKWTAPEAVNFHRFSVKSDVWSFGILLYELITYGRMPYPEMGNMEVLKQLDRGYR 406

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072])

HSP 1 Score: 88.5817 bits (218), Expect = 4.211e-18
Identity = 66/221 (29.86%), Postives = 108/221 (48.87%), Query Frame = 1

Query: 2530 HIIGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFS 3192
             +IGRG++G+VY  +A+N H   + VA K +   ++  E  D   E  +++ L H+NIV+  G   ++    +++++E    G LR  L+SR S      E+            ++      GL Y+H + ++HRDI   N L+S D  +KL DFG+        ST +      L+  + WM PE +     S  SDIWS G  + E++T    PY + +
Sbjct:   29 QVIGRGSYGVVY--KAINKHTD-QVVAIKEVVYENDE-ELNDIMAEISLLKNLNHNNIVKYHGFIRKSYE--LYILLEYCANGSLRR-LISRSSTGLSENES-----------KTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGV--------STIVNSSALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKN-PPYHNLT 222

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BLAST of receptor tyrosine kinase-1 vs. Ensembl Yeast
Match: ATG1 (Protein serine/threonine kinase; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p; essential for cell cycle progression from G2/M to G1 under nitrogen starvation [Source:SGD;Acc:S000003148])

HSP 1 Score: 84.7297 bits (208), Expect = 4.955e-17
Identity = 78/268 (29.10%), Postives = 127/268 (47.39%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKI--DFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESI--------ELRNRLN-----SFARDIAEGLNYMHSQFMVHRDIACRNCLIS------HD---FH------------IKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKR 3231
            IG+G+F  VY G   +     + VA K +S +    +K+  +   E  +++K+KH +IV LI    E  +   +LIME    GDL  +LL RR K  +     L ++        E  N L+     S+ + +A  L ++ S+ +VHRDI  +N L+S      HD   FH            +K+ DFG  R+L P  S         L     +M PE + +  ++ K+D+WS G ++FE+     C    F ++ +++L  +IKR
Sbjct:   30 IGKGSFATVYRGHLTSDKS--QHVAIKEVSRAKLKNKKLLENLEIEIAILKKIKHPHIVGLIDC--ERTSTDFYLIMEYCALGDL-TFLLKRR-KELMENHPLLRTVFEKYPPPSENHNGLHRAFVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYNLPILKIADFGFARFL-PNTS-----LAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVVFEM----CCGTPPFRASNHLELFKKIKR 281

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BLAST of receptor tyrosine kinase-1 vs. Ensembl Yeast
Match: MKK1 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication [Source:SGD;Acc:S000005757])

HSP 1 Score: 82.0333 bits (201), Expect = 1.716e-16
Identity = 58/210 (27.62%), Postives = 99/210 (47.14%), Query Frame = 1

Query: 2533 IIGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNR-LNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELV 3159
            I+G GA G V   +  N   +       T++    + ++I  F E +  R  +   IV   G+  ++EN+ I++ ME M            RS  AIY+        +  + L   A  +  GL+Y+H + ++HRDI  +N L++ +  +KL DFG++   +   +T    F G       +M PE IQ   +S+ SD+WS G+ + E+ 
Sbjct:  226 ILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQI--FRELQFNRSFQSEYIVRYYGMFTDDENSSIYIAMEYM----------GGRSLDAIYKNLLERGGRISEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLAT---TFTGT----SFYMAPERIQGQPYSVTSDVWSLGLTILEVA 416

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BLAST of receptor tyrosine kinase-1 vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144])

HSP 1 Score: 82.8037 bits (203), Expect = 2.500e-16
Identity = 69/235 (29.36%), Postives = 111/235 (47.23%), Query Frame = 1

Query: 2530 HIIGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKH-SNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGI-FSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIK 3228
             +IGRG FG+VY G  +   G + A+    +   S+ +E  D   E + +  LK  SNI    G  L++ +  +++IME    G LR+ L          R   ++       +    R++   L  +H   ++HRDI   N LI+++ ++KL DFG+      + +    + Q     P  WM PE I  G+ +  K DIWS GI  +E+ T G  PY D  + + + LI + K
Sbjct:   27 EVIGRGKFGVVYKGYNVKT-GRVYAIKVLNLDSDSDEVE--DVQREIQFLASLKQISNITRYYGSYLKDTS--LWIIMEHCAGGSLRSLL----------RPGKID----EKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAA----QVNQTSLRRQTMAGTPY-WMAPEVIMEGVYYDTKVDIWSLGITTYEIAT-GNPPYCDVEALRAMQLIIKSK 236

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Yeast
Match: CDC5 (Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants [Source:SGD;Acc:S000004603])

HSP 1 Score: 80.8777 bits (198), Expect = 7.394e-16
Identity = 71/239 (29.71%), Postives = 116/239 (48.54%), Query Frame = 1

Query: 2527 NHIIGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKI--DFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPE---GIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIK 3228
             H +G G F   +  +  +  G  E  AAKT++++S   EK      +E ++ + + H NIV+ I  C E+++N +++++E+   G L   LL RR          L   E+R     F   I   + YMHS+ ++HRD+   N     ++++K+GDFGL   L    S   Y   G  +    ++ PE   G   G  S + DIWS G++L+ L+  G  P+Q    N    + +RIK
Sbjct:   85 GHFLGEGGFARCF--QIKDDSG--EIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFID-CFEDDSN-VYILLEICPNGSLME-LLKRR--------KVLTEPEVR----FFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANE-SERKYTICGTPN----YIAPEVLMGKHSG-HSFEVDIWSLGVMLYALL-IGKPPFQARDVNT---IYERIK 294

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BLAST of receptor tyrosine kinase-1 vs. Ensembl Nematostella
Match: EDO47652 (Tyrosine-protein kinase receptor [Source:UniProtKB/TrEMBL;Acc:A7RLS3])

HSP 1 Score: 166.392 bits (420), Expect = 1.198e-45
Identity = 92/283 (32.51%), Postives = 164/283 (57.95%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALN--AHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSNNS 3378
            +G G+FGMVY GEA +   +     VA KT+SE+++  ++I+F  EA +M+  + +++V L+GV  + +  L+  +MELM  GDL+N+L S R +  +  +    +++   ++   A +IA+G+ Y+ ++  VHRD+A RNC+++ +  +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++++E+ T    PY   S+ + +  +  +   ++   D  P    D     L++ C  +    RP T   II +++ + S
Sbjct:   24 LGNGSFGMVYEGEATDIVPNKPKCKVAVKTVSENASIRDRIEFLQEASIMKAFQCNHVVRLLGVVSDGQPTLV--VMELMDNGDLKNFLRSHRPEVTMESDEPPPTLQ---QMLQMAGEIADGMAYLAARKFVHRDLAARNCMVNANLTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMAPESLKDGVFTSPSDVWSFGVVMWEMATLASQPYPGKSNEEVLKYV--VDGGVMPKPDDCPDRLFD-----LMTLCWQFSPKARP-TFLSIISLIEEDLS 290

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Nematostella
Match: EDO47195 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN18])

HSP 1 Score: 153.295 bits (386), Expect = 3.125e-41
Identity = 94/285 (32.98%), Postives = 148/285 (51.93%), Query Frame = 1

Query: 2530 HIIGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRP---ETMEQIIQILKSNN 3375
            H +G G +G VY G     +   + VA KT+ E +  +E  +F  EA VM+ +KH N+V+L+GVC        ++I E M+ G+L +YL S + K        L+++ L       A  +   ++Y+ S   +HRD+A RNCL+  +  +K+ DFGL+R +    S  IY        P++W  PE +    FSIKSD+W+FGILL+EL T+G+ PY     +Q  D +D   R  +   +  P       V+ L+  C  +  N+RP   E  E++  +  S+N
Sbjct:   18 HKLGGGQYGEVYEGTWKKYN---KTVAVKTLREETMEVE--EFLKEASVMKGIKHQNLVQLLGVCTREPP--FYIITEFMMNGNLLDYLRSPKGK-------DLDAVTLM----YMATQVGSAMSYLESMNFIHRDLAARNCLVGDNNLVKVADFGLSRLV----SEDIYTAHQGAKFPIKWTAPEALAHNTFSIKSDVWAFGILLWELATYGMSPYPGIDLSQVYDKLDGGYR--MPCPEGCPPE-----VYSLMQTCWCWDPNSRPSFKEIHEKLNTMFPSSN 273

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Nematostella
Match: EDO45490 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RSX1])

HSP 1 Score: 137.887 bits (346), Expect = 1.069e-36
Identity = 71/206 (34.47%), Postives = 117/206 (56.80%), Query Frame = 1

Query: 2605 VAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDR 3222
            VA KT+ +  +   K  F  E  +M  L H NIVEL+ V  E E     +I E M +GDL  Y+  +R   ++  E SL     +  L S +  ++ G+ ++ S   VHRD+A RNCL+     +K+ DFG++R +    ++  YK +G   +P+RWMPPE + +G F+++SD++SFG+LL+E+  F + PY  +++ +    I +
Sbjct:    4 VAVKTLKQGCSNEMKTSFLQEVTLMAVLHHPNIVELLAVSTEEEP--YGMIFEFMSQGDLNQYM-RKRGPYSLEEEKSLT----QEDLLSISLQVSSGMEHLQSMRFVHRDLATRNCLVGDGLVVKIADFGMSRDVY---ASDYYKVEGQAVMPIRWMPPEALLYGRFTVESDVYSFGVLLWEVYAFALQPYYGYTNEEVCGFIKK 199

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Nematostella
Match: EDO44269 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RW90])

HSP 1 Score: 138.272 bits (347), Expect = 1.698e-36
Identity = 72/190 (37.89%), Postives = 112/190 (58.95%), Query Frame = 1

Query: 2647 KIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELR-NRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGV-CPYQDFSSNQNVD 3210
            K DFF E K+M  ++H N+V L+GVC   +++ + +I+E M  GDL  +L  R   +     NS +  ++    L   A  +A G+ Y+ S   VHRD+A RNCL+ H F +K+ DFG++R+L    S   Y+ QG + LP+RWM PE I  G F+  SD+W+FG+ L+E++T     PY D +  + ++
Sbjct:   11 KQDFFKEVKIMAGVRHENVVRLLGVC---KDDPMCMIVEYMENGDLNQFLKQRELASG----NSADPNKVTYQALLYMALQLAAGMKYIASHQFVHRDLATRNCLVGHSFTVKIADFGMSRHLY---SKHYYRIQGRVILPIRWMAPECILQGKFTSASDVWAFGVTLWEILTLAAEYPYGDLTDEKVIE 190

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Nematostella
Match: EDO49126 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGW8])

HSP 1 Score: 140.198 bits (352), Expect = 3.275e-36
Identity = 89/235 (37.87%), Postives = 131/235 (55.74%), Query Frame = 1

Query: 2527 NHIIGRGAFGMVYGGEALNAHGMLE----AVAAKTISESSNWIEKIDFFTEAKVMRKL-KHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESI----EL-RNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQ 3201
              ++G GAFG V     +   G  E     VA K ++  +   ++ +F +E ++M++L KH NIV ++G C+ +   L  LI E    GDLRNYL + R K +    +SL       EL +N L SFAR IA G+ Y+  +  VHRD+A RN LI  D  +K+ DFGLTR +    S+  +K      LP++WM PE I   + + KSD+W+FG++L+E+VT G  PY   S  +
Sbjct:   21 GEVVGSGAFGKVTKATIVGLPGGPENKETVVAVKKLNAMATMEDRRNFLSEIEMMKQLGKHLNIVSILG-CVTHAGQLC-LITEYCPYGDLRNYLRAIRDKVST--RDSLAGRAPGRELTQNDLLSFARQIAVGMEYLSQKMFVHRDLAARNILICEDNLVKISDFGLTRDVYE--SSEYHKMHNTGKLPLKWMAPEAIFQNVHTTKSDVWAFGVVLWEIVTLGGSPYPGQSGKE 249

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Medaka
Match: igf1rb (insulin-like growth factor 1 receptor [Source:NCBI gene;Acc:101163560])

HSP 1 Score: 183.726 bits (465), Expect = 2.537e-46
Identity = 105/277 (37.91%), Postives = 164/277 (59.21%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQI 3351
            +G+G+FGMVY G A    G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S R K   +   SL  ++   ++   A  IA+G+ Y++S   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL      PQ+  D ++  L+  C  Y    RP  +E I
Sbjct: 1007 LGQGSFGMVYEGVA---KGVVKDEPETKVAVKTVNESASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRPKEQQWSSLSLPPLK---KMLQMAGQIADGMAYLNSNKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV--MEGGLLE----KPQNCPD-MLFELMRMCWQYNPKMRPSFVEII 1265

[Close]

Query: 2536 IGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQI 3351
            +G+G+FGMVY G A    G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S R K   +   SL  ++   ++   A  IA+G+ Y++S   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL      PQ+  D ++  L+  C  Y    RP  +E I
Sbjct: 1007 LGQGSFGMVYEGVA---KGVVKDEPETKVAVKTVNESASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRPKEQQWSSLSLPPLK---KMLQMAGQIADGMAYLNSNKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV--MEGGLLE----KPQNCPD-MLFELMRMCWQYNPKMRPSFVEII 1265

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Medaka
Match: igf1rb (insulin-like growth factor 1 receptor [Source:NCBI gene;Acc:101163560])

HSP 1 Score: 183.341 bits (464), Expect = 2.992e-46
Identity = 105/277 (37.91%), Postives = 164/277 (59.21%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQI 3351
            +G+G+FGMVY G A    G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S R K   +   SL  ++   ++   A  IA+G+ Y++S   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL      PQ+  D ++  L+  C  Y    RP  +E I
Sbjct: 1007 LGQGSFGMVYEGVA---KGVVKDEPETKVAVKTVNESASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRPKEQQWSSLSLPPLK---KMLQMAGQIADGMAYLNSNKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV--MEGGLLE----KPQNCPD-MLFELMRMCWQYNPKMRPSFVEII 1265

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Medaka
Match: igf1rb (insulin-like growth factor 1 receptor [Source:NCBI gene;Acc:101163560])

HSP 1 Score: 183.341 bits (464), Expect = 3.311e-46
Identity = 105/277 (37.91%), Postives = 164/277 (59.21%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQI 3351
            +G+G+FGMVY G A    G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S R K   +   SL  ++   ++   A  IA+G+ Y++S   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL      PQ+  D ++  L+  C  Y    RP  +E I
Sbjct: 1007 LGQGSFGMVYEGVA---KGVVKDEPETKVAVKTVNESASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRPKEQQWSSLSLPPLK---KMLQMAGQIADGMAYLNSNKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV--MEGGLLE----KPQNCPD-MLFELMRMCWQYNPKMRPSFVEII 1265

[Close]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Medaka
Match: igf1rb (insulin-like growth factor 1 receptor [Source:NCBI gene;Acc:101163560])

HSP 1 Score: 182.956 bits (463), Expect = 3.501e-46
Identity = 105/277 (37.91%), Postives = 164/277 (59.21%), Query Frame = 1

Query: 2536 IGRGAFGMVYGGEALNAHGMLE-----AVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQI 3351
            +G+G+FGMVY G A    G+++      VA KT++ES++  E+I+F  EA VM++    ++V L+GV  + +  L+  IMELM  GDL++YL S R K   +   SL  ++   ++   A  IA+G+ Y++S   VHRD+A RNC+++ DF +K+GDFG+TR +     T  Y+  G   LPVRWM PE ++ G+F+  SD+WSFG++L+E+ T    PYQ  S+ Q +  +  ++  LL      PQ+  D ++  L+  C  Y    RP  +E I
Sbjct: 1007 LGQGSFGMVYEGVA---KGVVKDEPETKVAVKTVNESASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV--IMELMTRGDLKSYLRSLRPKEQQWSSLSLPPLK---KMLQMAGQIADGMAYLNSNKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY---ETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV--MEGGLLE----KPQNCPD-MLFELMRMCWQYNPKMRPSFVEII 1265

[Close]

BLAST of receptor tyrosine kinase-1 vs. Planmine SMEST
Match: SMESG000025275.1 (SMESG000025275.1)

HSP 1 Score: 2499.16 bits (6476), Expect = 0.000e+0
Identity = 1261/1261 (100.00%), Postives = 1261/1261 (100.00%), Query Frame = 1

Query:   67 LGLFICFFQLIVAIQLQILGDYGLCLPEKDRVNISRNIFEGIDSIFIEXXXXXXXXXXXXXXXXXXXERLGYKTSIRDADWDNVTAAISRLACNKKSCESSKPESHINMEIWMPAGFTNSEWVNRDLIIDCGPLGPIAKTGIFYFNHENKNYPLDDWRRLQETTRQNFPKTYHDKSVFRHFMIFGNCNDSTSSLCRTQFAIDSKLPNRHAHVLNNLYKNWSIGSVLSDEFTKFYFTWYPNAITTQYKMSRILFPDCKYTDSNFPDSYCDDSINQLAKIVWFGIKTKAPLIYNLVDSFQLTQEDLVGFLKEVNISSGNIEQEYFKIACNWVLNYKAAWKPFTVGWNTTKELYIIILLPNTDSNISQDEKNALKSALRYLNNNFSYFGSRQYKVLVKYTNVTCEQSDIIQEYLKLVSPASEEEHHHEVGIISGLSTYCMNEIYKLTNAQRKIMVSFRHEIYPILARHGKNQILNISYIYQTMPSKEAYYFILEKLITTYDWKYVTIITDTDDYRSGLNASFIHKERVYQNKKIDKALFDQFLRQNIEKLSARIFLLDFNEADIFQILCTAGKLKMTLENGFVWIINRYFVNQSIINSFLWCKSEIESITSNYLYLSPYIKPAVECSDFYSNNLFRAVKFLGKMVYFALKKNPSFFEFNSDILMNYSRNVESREYFCSGKLISHSPIKMNENSFFWKVWSLYKINGSKTTTLFEFTLSEKFHILDTYEYKLKKIQSWNPPKDASLNEDCWVGSLTKILHVNCVIAEMLVLMTISXXXXXXXXXXXXXXYKYKTRKIYYPMKTVFHELVQXXXXXXXXXXXXXXNHIIGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSNNSCIRPYLTEDPPKFEGDKNLDNLSMNLPGIVIEDDEVTFTSPSEMHLDSSQKRINIINRAFGIKSVSVKEKTDFPVRQLRPCQSSVFISRNQLSEENIDSMRMKKPLDIFVSSIPTDLCYNTGFPKKPRTSTRSMSNFLKISPKTSNFKLKILSKDFQ 3849
            LGLFICFFQLIVAIQLQILGDYGLCLPEKDRVNISRNIFEGIDSIFIESTRRSSHRIVSHIISILIRERLGYKTSIRDADWDNVTAAISRLACNKKSCESSKPESHINMEIWMPAGFTNSEWVNRDLIIDCGPLGPIAKTGIFYFNHENKNYPLDDWRRLQETTRQNFPKTYHDKSVFRHFMIFGNCNDSTSSLCRTQFAIDSKLPNRHAHVLNNLYKNWSIGSVLSDEFTKFYFTWYPNAITTQYKMSRILFPDCKYTDSNFPDSYCDDSINQLAKIVWFGIKTKAPLIYNLVDSFQLTQEDLVGFLKEVNISSGNIEQEYFKIACNWVLNYKAAWKPFTVGWNTTKELYIIILLPNTDSNISQDEKNALKSALRYLNNNFSYFGSRQYKVLVKYTNVTCEQSDIIQEYLKLVSPASEEEHHHEVGIISGLSTYCMNEIYKLTNAQRKIMVSFRHEIYPILARHGKNQILNISYIYQTMPSKEAYYFILEKLITTYDWKYVTIITDTDDYRSGLNASFIHKERVYQNKKIDKALFDQFLRQNIEKLSARIFLLDFNEADIFQILCTAGKLKMTLENGFVWIINRYFVNQSIINSFLWCKSEIESITSNYLYLSPYIKPAVECSDFYSNNLFRAVKFLGKMVYFALKKNPSFFEFNSDILMNYSRNVESREYFCSGKLISHSPIKMNENSFFWKVWSLYKINGSKTTTLFEFTLSEKFHILDTYEYKLKKIQSWNPPKDASLNEDCWVGSLTKILHVNCVIAEMLVLMTISFFILLVFIFIILIFYKYKTRKIYYPMKTVFHELVQDLLDIDIDSSKLILNHIIGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSNNSCIRPYLTEDPPKFEGDKNLDNLSMNLPGIVIEDDEVTFTSPSEMHLDSSQKRINIINRAFGIKSVSVKEKTDFPVRQLRPCQSSVFISRNQLSEENIDSMRMKKPLDIFVSSIPTDLCYNTGFPKKPRTSTRSMSNFLKISPKTSNFKLKILSKDFQ
Sbjct:    4 LGLFICFFQLIVAIQLQILGDYGLCLPEKDRVNISRNIFEGIDSIFIESTRRSSHRIVSHIISILIRERLGYKTSIRDADWDNVTAAISRLACNKKSCESSKPESHINMEIWMPAGFTNSEWVNRDLIIDCGPLGPIAKTGIFYFNHENKNYPLDDWRRLQETTRQNFPKTYHDKSVFRHFMIFGNCNDSTSSLCRTQFAIDSKLPNRHAHVLNNLYKNWSIGSVLSDEFTKFYFTWYPNAITTQYKMSRILFPDCKYTDSNFPDSYCDDSINQLAKIVWFGIKTKAPLIYNLVDSFQLTQEDLVGFLKEVNISSGNIEQEYFKIACNWVLNYKAAWKPFTVGWNTTKELYIIILLPNTDSNISQDEKNALKSALRYLNNNFSYFGSRQYKVLVKYTNVTCEQSDIIQEYLKLVSPASEEEHHHEVGIISGLSTYCMNEIYKLTNAQRKIMVSFRHEIYPILARHGKNQILNISYIYQTMPSKEAYYFILEKLITTYDWKYVTIITDTDDYRSGLNASFIHKERVYQNKKIDKALFDQFLRQNIEKLSARIFLLDFNEADIFQILCTAGKLKMTLENGFVWIINRYFVNQSIINSFLWCKSEIESITSNYLYLSPYIKPAVECSDFYSNNLFRAVKFLGKMVYFALKKNPSFFEFNSDILMNYSRNVESREYFCSGKLISHSPIKMNENSFFWKVWSLYKINGSKTTTLFEFTLSEKFHILDTYEYKLKKIQSWNPPKDASLNEDCWVGSLTKILHVNCVIAEMLVLMTISFFILLVFIFIILIFYKYKTRKIYYPMKTVFHELVQDLLDIDIDSSKLILNHIIGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSNNSCIRPYLTEDPPKFEGDKNLDNLSMNLPGIVIEDDEVTFTSPSEMHLDSSQKRINIINRAFGIKSVSVKEKTDFPVRQLRPCQSSVFISRNQLSEENIDSMRMKKPLDIFVSSIPTDLCYNTGFPKKPRTSTRSMSNFLKISPKTSNFKLKILSKDFQ 1264

[Close]

BLAST of receptor tyrosine kinase-1 vs. Planmine SMEST
Match: SMESG000057226.1 (SMESG000057226.1)

HSP 1 Score: 480.33 bits (1235), Expect = 9.861e-147
Identity = 337/1092 (30.86%), Postives = 554/1092 (50.73%), Query Frame = 1

Query:  268 ERLGYKTSIRDADWDNVTAAISRLACNKKSCESSKPESHINMEIWMPAGFTNSEWVNRDLIIDCGPLGPIAKTGIFYFNHENKNY------PLDDWRRLQETTRQNFPKTYHDKSVFRHFMIFGNCNDSTSSLCRTQFAIDSKLPNRHAHVLNNLYKNWSIG-----SVLSDEFTKFYFTWYPNAITTQYKMSRILFPDCKYTDSNFPDSYCDDSINQLAKIVWFGIKTKAPLIYNLVDSFQLTQEDLVGFLKEVNISSGNIEQEYFKIACNWVLNYKAAWKPFTVGWNTTKELYIIILLPNTDSNISQDEKNALKSALRYLNNNFSYFGSRQYKVLVKYTNVTCEQSDIIQEYLKLVSPASEEEHHHEVGIISGLSTYCMNEIYKLTNAQRKIMVSFRHEIYPILARHGKNQILNISYIYQTMPSKEAYYFILEKLITTYDWKYVTIITDTDDY-----RSGLNASFIHKERVYQNKKIDKALFDQFLRQNIEKLSARIFLLDFNEADIFQILCTAGKLKMTLENGFVWIINRYFVNQSIINSFL-WCKSEIESITSNYLYL---------SPYIKPAVECSDFYSNNLFRAVKFLGKMVYFALKKN---------PSFFEFNSDILMNYSRNVESREYFCSGKLISHSPIKMNENSFFWKVWSLYKI-----NGSKTTTLFEFTLSEKFHI---LDTYEYKLKKIQSWNPPKDASLNEDCWVGSLTKILHVNCVIAEMLVLMTISXXXXXXXXXXXXXXYKYKTRKIYYPMKTVFHELVQXXXXXXXXXXXXXXNHIIGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLSLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQILKSNNSCIRPYLTEDPPK 3414
            ERLGYK +    +WD     I R +C    C    P SHIN+E+W   G+T ++  ++  ++DCGPLGPI + G+F  ++E +N        +D W+ L++   Q  P+                 + S  S+ +  F    ++      +  +L+++  I       +++   T  +  WYPN +T +   +R+LFPDC        DS C+  +NQ+ K+VW  +K  A   + L+  F L Q++ V  LK VN  S N   EYF++AC+WV N +  W  +T GWN  + +YI +L+ +     + +  N+    ++ +N N   F +  Y V+     + C+   I+ +YL +     E+     +G I  L     + + KLT+ Q +I++S        +       I   S+ + T PS   Y  +L  L+    W  V I+ +  ++      +  N + + K  V ++K      + +FL        A IF++D+       ++C AG L MTL+N + +I+N +       NS +  CK     I+  Y  +           YIK      ++ +     A+ ++GK     L++          P   E   DIL+N+ +++   +     K+ +    K + N     +W  ++I     N   T  LF + +S +  +   ++  +  +   +  N   D +   +C V SL KIL+ +C    +L+ +     I+++F   +L +Y  ++ +I    K  F +L  +L +IDI S+ +I+N  +G+GAFG+VYGGEA   +   E+VA K I + +++  KIDF TEAK+MR L H NIV+LIG+CL     +I+L+MEL+V GDL ++LLS R  A    ++S+  +     L  F +DIA G +Y+H   ++HRD+ACRNC IS D+ IK+GDFGLTR++        Y+   +  LP RWMPPE +QFG FSI+SDIWS G+++FE+ TF   PY + S ++  +L   +KRN + +I YLP++ K S V++LI +CC Y  + RP++M+ II  L  N  CI+PYLT DPP+
Sbjct:   71 ERLGYKVNFTYQNWDPTNDVIRRFSCQYNQCHDGSPISHINLEVWKSPGYTFND-DDKQHVVDCGPLGPIVRKGLFVNSNEVENIFYKEKKVIDHWKFLKKNA-QFCPQK----------------SQSCFSIYKPNFP---EMEKEFNDISKDLFQDTIISYMSNFPIINQSHTDIFLDWYPNVLTVKRNFTRLLFPDCS---DPIIDSACNFEVNQVNKVVWRHVKDHADRAFELIRDFMLDQDEYVNLLKNVNEDSDN---EYFRVACDWVNNNRQKWYEWTTGWNVKENMYIPVLISDYGLWKATEAHNSSIYGIKNINKNL--FNNTYYHVVPIIHELPCDVDTILNDYLNITEKYGEK----ILGFIVCLCPQTFSNVIKLTDLQNQIIISSS------IDSTNNGNISKYSHFFNTFPSMVNYNLVLINLLQKLHWNRVVILANDMNFVDIHLLTKGNITILDKRYVDESKLTYNDTY-KFLENAKRVHKASIFIIDYYNYGTQIVMCAAGHLGMTLDNSYAFILNPFVDPHWWENSTITQCKKNTAFISKEYFVIIHDTAAAHRDNYIKHKTMKFNYLAQLTHDAILYMGKSFRNLLQETASAYLSWHEPDVSEKYIDILLNHEQDIIGLKNLYKQKIFNR---KHDRNG----IWQFHQIASFSRNIIITMPLFSWEISFETGLPIRMNKTKTSIYYGKFQNSLPDYNQESNCPVESLRKILNWSCTATLLLINLLSILLIIIIFTGALLFYYFRQSVQIEDRNKKPFEDLCAELTEIDIRSTDVIINLQVGKGAFGIVYGGEA-KQNNHWESVAIKLIKKEADFQGKIDFLTEAKLMRNLDHPNIVKLIGICLNPPKPVIYLVMELLVNGDLEDHLLSHRITA---HKDSMNKLVCPMLLTRFVKDIASGADYLHQNNLLHRDLACRNCFISEDYMIKIGDFGLTRHISDSQENQYYRVSRHFVLPARWMPPEAVQFGYFSIQSDIWSLGVIIFEIATFCSRPYYNVSDDEVPEL---VKRNTMPLITYLPENCKGSHVYKLIEKCCQYKRDERPDSMKNIITYLDQNPECIKPYLTVDPPQ 1108

[Close]

BLAST of receptor tyrosine kinase-1 vs. Planmine SMEST
Match: SMESG000023258.1 (SMESG000023258.1)

HSP 1 Score: 323.939 bits (829), Expect = 2.911e-91
Identity = 283/983 (28.79%), Postives = 469/983 (47.71%), Query Frame = 1

Query:  373 PESHINMEIWMPAGFTNSEWVNRDLIIDCGPLGPIAKTGIF--------YFNHENKNYPLDDWRRLQETTRQ-NFPKTYHDKSVFRHFMIFGNCN----DSTSSLCRTQFAIDSKLPNRHAHVLNNLYKN-----------------WSIGSVLSDEFTK----FYFTWYPNAITTQYKMSRILFPDCKYTDSNFPDSYCDDSINQLAKIVWFGIKTKAPLIYNLVDSFQLTQEDLVGFLKEVNISSGNIEQEYFKIACNWVLNYKAAWKPFTVGWNTTKELYIIIL-------LPNTDSNISQDEKNALKSALRYLNNNFSYFGSRQYKVLVKYTNVTCEQSDIIQEYLKLVSPASEEEHHHEVGIISGLSTYCMNEIYKLTNAQRKIMVSFRHEIYPILARHGKNQILNISYIYQTMPSKEAYYFILEKLITTYDWKYVTIITDTDDYRSGLNASFIHKE--RVYQNKKIDKALFD-----QFLRQNIEKLSARIFLLDFNEADIFQILCTAGKLKMTLENGFVWIINRYFVNQ-SIINSFLWCKSEIESITSNYLYLSP--------------YIKPAVECSDFYSNNL----FRAVKFLGKMVYFALKKNPS-------------FFEFNSDILMNYSRNVESREYFCSGKLISHSPIKMNENSFFWKVWSLYKINGSKTTTLFEFTLSEKFHILDTYEYKLKKIQ-SWNPPKDASLN---EDCWVGSLTKILHVNCVIAEMLVLMTISXXXXXXXXXXXXXXYKYKTRKIYYP--MKTVFHELVQXXXXXXXXXXXXXXNHIIGRGAFGMVYGGEAL-NAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIP---RCSTGIYKFQG 3051
            PE+HIN+E+W P GF    WVN+ L++DCGPLGPIA+ GIF         FN  N++  +D W+      +  N+   Y   +V + ++     +    D    +      +   L N  + V N    N                 W + +   D+       F++ WYPN +T   + +R+LFPDC     N     CD  +NQ++K++W  +K+ + L+Y LV+ F++ + DLV  LKEV   + N ++  F+IACNW L     W+ +  GWN   +L I  L       +P+   N S  E   L         N  +F +  Y++++   N++C +  +++EYL+    A   +    V  ++ + +  +    K++  Q +I+V+   +  P      K Q     Y Y+T+PS      +L  +   Y WK ++I+     +    ++ F      +V ++ KID ++       Q L++   K + RIF++++       I+C A KL M+LENGFVW +N +  N    + +      EI++IT NY  ++               Y  P +   +++ N+       A++ +G+ ++  L +NP+             F  F S+  +N  +N+   E    G  +  + +  N  S   K +   +      T L +  +++   I   +  K+   +  + PP D S+     +C  G    IL ++C  A +LV   I    +L+ I I   F+  + RK      +K  F  L Q+L+D+DI    +++N  +G+G FG+VYGGEA  N H +L  VA K IS+  ++  K +F +EAK+M  L H NIV+L+G+ L   N +I+LIME +  GDL+ +L+ RR K    +E+          L  FARDIA GL Y+H    +HRD+ACRNCL++ D+ IK+GDFGL R +     +  TG Y+F G
Sbjct:  103 PETHINLELWQPPGFNVEAWVNKGLVLDCGPLGPIARQGIFTPSDTVDTVFNKFNES--IDHWKVFDYMPKNWNYSDLYIWLTVNKSWVTVDGFSPKYVDKIPIILIDNKDLKKPLQNLFSSVFNQKISNVILMINTTGSLKQTIDDWFVFAASRDDLAVKSPLFFYDWYPNIVTVNQRFNRVLFPDCYGIKEN---PLCDFEVNQMSKMIWSKLKSVSSLVYQLVNQFKIPESDLVELLKEVKSENDN-DESLFQIACNW-LKKDNKWESWIKGWNVKHKLVIPGLFSLYGKWVPDCLLNDSLREVQEL---------NRKHFNNTSYELVLDVRNLSCIEDLVLKEYLQY--SARHNDSATTVAYLAAVCSDSLESTLKVSTFQHRIIVTSTAD-SPKFG--NKTQ---YKYFYRTIPSMNVQKSLLLSIFQHYKWKRISILRKDSMF---FDSEFFENNGIKVLEDPKIDDSILTFNLAYQTLKRIRYKKNGRIFIVEYFAEATRVIMCAAYKLGMSLENGFVWFLNPWMNNHWDRVKTDNCTIEEIQNITHNYFQVAHRNLYTFTDKRMIDNYNNPDI--GEYHQNSFSVFTIEALRKIGQAIFKLLSENPNVLSVFHKEEVAKKFISFISNTHLNNKKNLGVSE----GTWLMVASVG-NTKSPLLKWYFNSRSVERNLTGLIKVPITQI--IGSEFNNKIWYAKYGFRPPGDGSVKSVVSECVFG-FNVILGLSC-WATVLVTNAIILTPILILILICFWFFFRRLRKTQEEEGLKKPFEFLCQELVDLDISGKDVVINRTVGKGNFGIVYGGEARQNNHWVL--VAIKAISKKLDYRFKYEFLSEAKLMSNLNHENIVKLVGISLNPNNEMIYLIMEHVTGGDLKKFLIKRRVKV---KEDPKNDRINPKSLTKFARDIASGLYYLHENHYLHRDVACRNCLVNSDYGIKVGDFGLARRITKFNRKGGTGYYRFSG 1042

[Close]

BLAST of receptor tyrosine kinase-1 vs. Planmine SMEST
Match: SMESG000023258.1 (SMESG000023258.1)

HSP 1 Score: 323.553 bits (828), Expect = 3.914e-91
Identity = 283/983 (28.79%), Postives = 469/983 (47.71%), Query Frame = 1

Query:  373 PESHINMEIWMPAGFTNSEWVNRDLIIDCGPLGPIAKTGIF--------YFNHENKNYPLDDWRRLQETTRQ-NFPKTYHDKSVFRHFMIFGNCN----DSTSSLCRTQFAIDSKLPNRHAHVLNNLYKN-----------------WSIGSVLSDEFTK----FYFTWYPNAITTQYKMSRILFPDCKYTDSNFPDSYCDDSINQLAKIVWFGIKTKAPLIYNLVDSFQLTQEDLVGFLKEVNISSGNIEQEYFKIACNWVLNYKAAWKPFTVGWNTTKELYIIIL-------LPNTDSNISQDEKNALKSALRYLNNNFSYFGSRQYKVLVKYTNVTCEQSDIIQEYLKLVSPASEEEHHHEVGIISGLSTYCMNEIYKLTNAQRKIMVSFRHEIYPILARHGKNQILNISYIYQTMPSKEAYYFILEKLITTYDWKYVTIITDTDDYRSGLNASFIHKE--RVYQNKKIDKALFD-----QFLRQNIEKLSARIFLLDFNEADIFQILCTAGKLKMTLENGFVWIINRYFVNQ-SIINSFLWCKSEIESITSNYLYLSP--------------YIKPAVECSDFYSNNL----FRAVKFLGKMVYFALKKNPS-------------FFEFNSDILMNYSRNVESREYFCSGKLISHSPIKMNENSFFWKVWSLYKINGSKTTTLFEFTLSEKFHILDTYEYKLKKIQ-SWNPPKDASLN---EDCWVGSLTKILHVNCVIAEMLVLMTISXXXXXXXXXXXXXXYKYKTRKIYYP--MKTVFHELVQXXXXXXXXXXXXXXNHIIGRGAFGMVYGGEAL-NAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIP---RCSTGIYKFQG 3051
            PE+HIN+E+W P GF    WVN+ L++DCGPLGPIA+ GIF         FN  N++  +D W+      +  N+   Y   +V + ++     +    D    +      +   L N  + V N    N                 W + +   D+       F++ WYPN +T   + +R+LFPDC     N     CD  +NQ++K++W  +K+ + L+Y LV+ F++ + DLV  LKEV   + N ++  F+IACNW L     W+ +  GWN   +L I  L       +P+   N S  E   L         N  +F +  Y++++   N++C +  +++EYL+    A   +    V  ++ + +  +    K++  Q +I+V+   +  P      K Q     Y Y+T+PS      +L  +   Y WK ++I+     +    ++ F      +V ++ KID ++       Q L++   K + RIF++++       I+C A KL M+LENGFVW +N +  N    + +      EI++IT NY  ++               Y  P +   +++ N+       A++ +G+ ++  L +NP+             F  F S+  +N  +N+   E    G  +  + +  N  S   K +   +      T L +  +++   I   +  K+   +  + PP D S+     +C  G    IL ++C  A +LV   I    +L+ I I   F+  + RK      +K  F  L Q+L+D+DI    +++N  +G+G FG+VYGGEA  N H +L  VA K IS+  ++  K +F +EAK+M  L H NIV+L+G+ L   N +I+LIME +  GDL+ +L+ RR K    +E+          L  FARDIA GL Y+H    +HRD+ACRNCL++ D+ IK+GDFGL R +     +  TG Y+F G
Sbjct:   95 PETHINLELWQPPGFNVEAWVNKGLVLDCGPLGPIARQGIFTPSDTVDTVFNKFNES--IDHWKVFDYMPKNWNYSDLYIWLTVNKSWVTVDGFSPKYVDKIPIILIDNKDLKKPLQNLFSSVFNQKISNVILMINTTGSLKQTIDDWFVFAASRDDLAVKSPLFFYDWYPNIVTVNQRFNRVLFPDCYGIKEN---PLCDFEVNQMSKMIWSKLKSVSSLVYQLVNQFKIPESDLVELLKEVKSENDN-DESLFQIACNW-LKKDNKWESWIKGWNVKHKLVIPGLFSLYGKWVPDCLLNDSLREVQEL---------NRKHFNNTSYELVLDVRNLSCIEDLVLKEYLQY--SARHNDSATTVAYLAAVCSDSLESTLKVSTFQHRIIVTSTAD-SPKFG--NKTQ---YKYFYRTIPSMNVQKSLLLSIFQHYKWKRISILRKDSMF---FDSEFFENNGIKVLEDPKIDDSILTFNLAYQTLKRIRYKKNGRIFIVEYFAEATRVIMCAAYKLGMSLENGFVWFLNPWMNNHWDRVKTDNCTIEEIQNITHNYFQVAHRNLYTFTDKRMIDNYNNPDI--GEYHQNSFSVFTIEALRKIGQAIFKLLSENPNVLSVFHKEEVAKKFISFISNTHLNNKKNLGVSE----GTWLMVASVG-NTKSPLLKWYFNSRSVERNLTGLIKVPITQI--IGSEFNNKIWYAKYGFRPPGDGSVKSVVSECVFG-FNVILGLSC-WATVLVTNAIILTPILILILICFWFFFRRLRKTQEEEGLKKPFEFLCQELVDLDISGKDVVINRTVGKGNFGIVYGGEARQNNHWVL--VAIKAISKKLDYRFKYEFLSEAKLMSNLNHENIVKLVGISLNPNNEMIYLIMEHVTGGDLKKFLIKRRVKV---KEDPKNDRINPKSLTKFARDIASGLYYLHENHYLHRDVACRNCLVNSDYGIKVGDFGLARRITKFNRKGGTGYYRFSG 1034

[Close]

BLAST of receptor tyrosine kinase-1 vs. Planmine SMEST
Match: SMESG000015831.1 (SMESG000015831.1)

HSP 1 Score: 155.992 bits (393), Expect = 8.278e-40
Identity = 91/235 (38.72%), Postives = 131/235 (55.74%), Query Frame = 1

Query: 2533 IIGRGAFGMVYGGEALNAHGMLEAVAAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLIMELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNYMHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNLS-LPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNVDLIDRIKRN 3234
            ++G+G FG V+  +A         VA K I   S+ +    F TEAKVM KL+H  IVEL+GVC + EN  I++I E M  GDL + L S+  ++  ++           +L      I+EG+ Y+ S+  VHRD+   N L+  +F +K+ DFGL R L     +    +  N S  PVRW  PE + +G FS KSD+WSFGIL++E+VT+G  PY   S+ + +D I   KRN
Sbjct:  233 VLGKGCFGEVW--QAKWGERGSHVVAIKVIQ--SDMMSNEQFLTEAKVMHKLRHPKIVELLGVCTQPENQPIYIITEFMCNGDLLSLLKSQIGRSFDFK-----------KLIDIIAQISEGMAYLESKLYVHRDLRAANILVDANFMVKVADFGLARVLQQDEES----YTANESKFPVRWTAPEAV-YGTFSTKSDVWSFGILIYEIVTYGAMPYSTMSTKEVLDEI--TKRN 445

The following BLAST results are available for this feature:

BLAST of receptor tyrosine kinase-1 vs. Ensembl Human
BLAST of receptor tyrosine kinase-1 vs. Ensembl Celegans
BLAST of receptor tyrosine kinase-1 vs. Ensembl Fly
BLAST of receptor tyrosine kinase-1 vs. Ensembl Zebrafish
BLAST of receptor tyrosine kinase-1 vs. Ensembl Xenopus
BLAST of receptor tyrosine kinase-1 vs. Ensembl Mouse
BLAST of receptor tyrosine kinase-1 vs. UniProt/SwissProt
BLAST of receptor tyrosine kinase-1 vs. TrEMBL
BLAST of receptor tyrosine kinase-1 vs. Ensembl Cavefish
BLAST of receptor tyrosine kinase-1 vs. Ensembl Sea Lamprey
BLAST of receptor tyrosine kinase-1 vs. Ensembl Yeast
BLAST of receptor tyrosine kinase-1 vs. Ensembl Nematostella
BLAST of receptor tyrosine kinase-1 vs. Ensembl Medaka
BLAST of receptor tyrosine kinase-1 vs. Planmine SMEST

BLAST of receptor tyrosine kinase-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
INSR	6.864e-46	36.65	insulin receptor [Source:HGNC Symbol;Acc:HGNC:6091...	[more]
INSR	7.775e-46	36.65	insulin receptor [Source:HGNC Symbol;Acc:HGNC:6091...	[more]
IGF1R	5.415e-44	36.07	insulin like growth factor 1 receptor [Source:HGNC...	[more]
IGF1R	5.804e-44	36.07	insulin like growth factor 1 receptor [Source:HGNC...	[more]
FER	1.712e-43	34.07	FER tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:3...	[more]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
svh-2	1.040e-39	40.27	Tyrosine-protein kinase receptor svh-2 [Source:Un...	[more]
svh-2	1.228e-39	40.27	Tyrosine-protein kinase receptor svh-2 [Source:Un...	[more]
svh-2	1.228e-39	40.27	Tyrosine-protein kinase receptor svh-2 [Source:Un...	[more]
svh-2	1.397e-39	40.27	Tyrosine-protein kinase receptor svh-2 [Source:Un...	[more]
daf-2	2.757e-36	31.47	Insulin-like receptor Insulin-like receptor subuni...	[more]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
InR	2.407e-42	33.22	gene:FBgn0283499 transcript:FBtr0290232	[more]
InR	2.407e-42	33.22	gene:FBgn0283499 transcript:FBtr0290230	[more]
InR	2.407e-42	33.22	gene:FBgn0283499 transcript:FBtr0084121	[more]
InR	2.407e-42	33.22	gene:FBgn0283499 transcript:FBtr0290231	[more]
Ror	1.319e-41	36.09	gene:FBgn0010407 transcript:FBtr0079978	[more]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
igf1ra	6.069e-46	37.14	insulin-like growth factor 1a receptor [Source:ZFI...	[more]
igf1ra	6.404e-46	37.14	insulin-like growth factor 1a receptor [Source:ZFI...	[more]
igf1ra	7.156e-46	37.14	insulin-like growth factor 1a receptor [Source:ZFI...	[more]
igf1ra	8.225e-46	37.14	insulin-like growth factor 1a receptor [Source:ZFI...	[more]
igf1ra	9.093e-46	37.14	insulin-like growth factor 1a receptor [Source:ZFI...	[more]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
IGF1R	4.273e-45	36.75	insulin like growth factor 1 receptor [Source:NCBI...	[more]
IGF1R	4.534e-45	36.75	insulin like growth factor 1 receptor [Source:NCBI...	[more]
IGF1R	4.685e-45	36.75	insulin like growth factor 1 receptor [Source:NCBI...	[more]
IGF1R	4.762e-45	36.75	insulin like growth factor 1 receptor [Source:NCBI...	[more]
IGF1R	5.563e-45	36.75	insulin like growth factor 1 receptor [Source:NCBI...	[more]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Insr	1.484e-44	35.94	insulin receptor [Source:MGI Symbol;Acc:MGI:96575]	[more]
Igf1r	1.598e-44	36.62	insulin-like growth factor I receptor [Source:MGI ...	[more]
Insrr	1.318e-43	41.56	insulin receptor-related receptor [Source:MGI Symb...	[more]
Insrr	1.318e-43	41.56	insulin receptor-related receptor [Source:MGI Symb...	[more]
Fer	6.780e-43	33.33	fer (fms/fps related) protein kinase [Source:MGI S...	[more]

BLAST of receptor tyrosine kinase-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q05688\|IGF1R_BOVIN	2.234e-45	35.71	Insulin-like growth factor 1 receptor (Fragment) O...	[more]
sp\|P06213\|INSR_HUMAN	3.296e-45	36.65	Insulin receptor OS=Homo sapiens OX=9606 GN=INSR P...	[more]
sp\|P15127\|INSR_RAT	5.200e-44	35.94	Insulin receptor OS=Rattus norvegicus OX=10116 GN=...	[more]
sp\|P24062\|IGF1R_RAT	5.404e-44	36.97	Insulin-like growth factor 1 receptor OS=Rattus no...	[more]
sp\|O73798\|IGF1R_XENLA	5.916e-44	36.04	Insulin-like growth factor 1 receptor OS=Xenopus l...	[more]

BLAST of receptor tyrosine kinase-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
I1ZIG2	0.000e+0	100.00	Receptor tyrosine kinase-1 (Fragment) OS=Schmidtea...	[more]
R7US23	5.927e-93	26.46	Guanylate cyclase (Fragment) OS=Capitella teleta O...	[more]
A0A2H1CG47	1.039e-90	46.61	Guanylate cyclase OS=Fasciola hepatica OX=6192 GN=...	[more]
A0A0V0J4S3	1.658e-89	43.96	Guanylate cyclase OS=Schistocephalus solidus OX=70...	[more]
Q8WSM2	4.696e-89	42.72	Guanylate cyclase OS=Schistosoma mansoni OX=6183 P...	[more]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
igf1ra	5.250e-46	37.14	insulin-like growth factor 1 receptor [Source:NCBI...	[more]
igf1rb	2.644e-45	37.50	insulin-like growth factor 1 receptor [Source:NCBI...	[more]
igf1ra	4.094e-45	38.17	insulin-like growth factor 1 receptor [Source:NCBI...	[more]
insrb	2.018e-44	37.01	insulin receptor b [Source:ZFIN;Acc:ZDB-GENE-02050...	[more]
insra	2.893e-44	36.56	insulin receptor [Source:NCBI gene;Acc:103039445]	[more]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000009485.1	4.335e-49	36.30	pep scaffold:Pmarinus_7.0:GL477866:1219:4704:1 gen...	[more]
ENSPMAT00000009481.1	5.439e-47	36.00	pep scaffold:Pmarinus_7.0:GL477866:614:5163:1 gene...	[more]
NTRK2	6.710e-42	37.23	neurotrophic receptor tyrosine kinase 2 [Source:HG...	[more]
ltk	9.574e-42	34.85	leukocyte receptor tyrosine kinase [Source:ZFIN;Ac...	[more]
frk	1.693e-38	36.64	fyn-related Src family tyrosine kinase [Source:ZFI...	[more]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
CDC15	4.211e-18	29.86	Protein kinase of the Mitotic Exit Network; locali...	[more]
ATG1	4.955e-17	29.10	Protein serine/threonine kinase; required for vesi...	[more]
MKK1	1.716e-16	27.62	MAPKK involved in the protein kinase C signaling p...	[more]
KIC1	2.500e-16	29.36	Protein kinase of the PAK/Ste20 family, required f...	[more]
CDC5	7.394e-16	29.71	Polo-like kinase; controls targeting and activatio...	[more]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO47652	1.198e-45	32.51	Tyrosine-protein kinase receptor [Source:UniProtK...	[more]
EDO47195	3.125e-41	32.98	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO45490	1.069e-36	34.47	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO44269	1.698e-36	37.89	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49126	3.275e-36	37.87	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of receptor tyrosine kinase-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
igf1rb	2.537e-46	37.91	insulin-like growth factor 1 receptor [Source:NCBI...	[more]
igf1rb	2.537e-46	37.91	insulin-like growth factor 1 receptor [Source:NCBI...	[more]
igf1rb	2.992e-46	37.91	insulin-like growth factor 1 receptor [Source:NCBI...	[more]
igf1rb	3.311e-46	37.91	insulin-like growth factor 1 receptor [Source:NCBI...	[more]
igf1rb	3.501e-46	37.91	insulin-like growth factor 1 receptor [Source:NCBI...	[more]

BLAST of receptor tyrosine kinase-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000025275.1	0.000e+0	100.00	SMESG000025275.1	[more]
SMESG000057226.1	9.861e-147	30.86	SMESG000057226.1	[more]
SMESG000023258.1	2.911e-91	28.79	SMESG000023258.1	[more]
SMESG000023258.1	3.914e-91	28.79	SMESG000023258.1	[more]
SMESG000015831.1	8.278e-40	38.72	SMESG000015831.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30024446
GenBank	AFJ24816.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30024446 ID=SMED30024446|Name=receptor tyrosine kinase-1|organism=Schmidtea mediterranea sexual|type=transcript|length=3876bp
AAGGTTTTCAAATTGGATGAATTTTAATTTACAAATTTTATAATATTTAA
AAATATTATGAATTTTTTGGGGTTATTTATATGTTTTTTTCAATTAATCG
TTGCTATTCAATTGCAAATACTCGGAGACTATGGTTTATGTCTTCCTGAA
AAAGACAGAGTAAATATCAGTAGAAATATTTTTGAAGGAATCGATTCTAT
TTTTATAGAGTCAACGAGAAGATCTTCGCATAGAATTGTATCACATATTA
TATCGATTTTAATAAGAGAACGCCTGGGTTATAAAACATCTATACGGGAT
GCAGATTGGGATAATGTCACGGCAGCCATTAGTAGATTGGCATGTAATAA
AAAATCTTGCGAAAGCAGTAAACCAGAATCACATATCAATATGGAAATTT
GGATGCCTGCAGGATTTACAAATTCTGAATGGGTGAATCGTGATTTAATC
ATTGATTGTGGGCCCCTAGGACCAATTGCTAAAACTGGAATATTTTATTT
TAACCACGAAAACAAAAACTATCCCCTTGATGATTGGCGTAGGCTTCAAG
AAACTACTCGACAAAACTTTCCCAAAACTTATCATGACAAATCGGTATTT
AGGCATTTTATGATTTTCGGTAATTGCAATGATTCAACCTCTTCATTGTG
CAGAACTCAATTCGCAATTGATTCAAAACTGCCCAATCGCCATGCCCATG
TTCTGAATAATTTATATAAAAATTGGAGTATTGGATCTGTGTTATCCGAT
GAATTTACCAAGTTCTACTTCACCTGGTACCCTAATGCTATTACAACTCA
ATATAAAATGTCTCGAATTTTATTTCCTGACTGCAAATACACTGATTCAA
ACTTCCCTGACTCCTATTGTGACGACTCGATTAACCAGCTAGCAAAGATC
GTGTGGTTTGGAATCAAAACTAAAGCACCACTAATATACAATTTGGTAGA
TTCATTTCAGTTAACTCAGGAAGATTTAGTTGGATTTTTGAAAGAGGTTA
ATATTTCATCTGGCAATATAGAACAAGAATATTTTAAAATAGCTTGTAAT
TGGGTACTCAACTATAAAGCTGCCTGGAAACCATTTACGGTTGGTTGGAA
TACCACAAAAGAGCTATACATAATTATTCTTTTGCCTAACACGGACTCTA
ATATTTCACAGGATGAAAAAAATGCGTTAAAATCGGCATTGCGATATTTG
AACAACAATTTTTCATATTTTGGTAGCCGTCAGTATAAGGTGCTAGTAAA
ATACACTAACGTTACTTGTGAGCAATCCGATATTATCCAAGAATATCTAA
AACTAGTTAGCCCTGCATCTGAAGAAGAGCATCATCATGAAGTGGGAATT
ATATCTGGCTTGTCTACTTATTGTATGAATGAAATCTATAAGTTAACGAA
TGCACAAAGAAAAATCATGGTGAGTTTTCGACATGAAATATATCCGATAT
TAGCTCGACATGGTAAAAATCAGATTTTGAATATTTCATATATCTATCAA
ACAATGCCATCAAAAGAAGCATATTATTTTATTTTGGAAAAATTAATCAC
GACTTATGATTGGAAATATGTGACAATCATTACAGACACTGATGACTATA
GGAGTGGTCTAAATGCCAGTTTTATTCACAAGGAACGGGTCTATCAAAAT
AAGAAAATAGACAAAGCCCTTTTTGATCAGTTTCTTCGGCAAAATATAGA
GAAATTAAGTGCGAGAATTTTCCTGTTGGATTTTAATGAAGCTGATATTT
TCCAAATATTATGCACAGCGGGGAAATTAAAAATGACACTAGAAAATGGA
TTTGTTTGGATCATAAATCGATATTTTGTAAATCAGTCAATAATAAACAG
TTTTTTATGGTGCAAATCTGAAATCGAATCAATTACTTCAAATTATTTAT
ATCTCAGTCCATATATCAAACCCGCTGTCGAGTGCAGTGACTTTTATTCA
AATAATTTATTTCGAGCTGTGAAATTTCTAGGAAAGATGGTCTATTTTGC
CCTTAAAAAAAATCCAAGTTTTTTTGAGTTCAATTCGGATATTCTGATGA
ATTATTCTCGCAATGTAGAATCCAGGGAATATTTTTGTTCAGGAAAATTG
ATATCCCATTCTCCTATCAAGATGAACGAAAATTCATTTTTCTGGAAAGT
TTGGAGTCTTTATAAAATTAATGGAAGTAAAACTACAACACTTTTTGAAT
TTACACTTTCTGAAAAATTTCATATTTTGGACACTTACGAATATAAGTTA
AAGAAAATCCAATCTTGGAATCCCCCGAAAGACGCCAGTTTAAATGAAGA
TTGTTGGGTTGGATCATTGACGAAAATTCTACACGTAAACTGTGTTATTG
CTGAAATGCTAGTTCTGATGACCATCTCATTTTTTATACTTTTGGTCTTC
ATATTTATCATTTTGATTTTCTACAAGTATAAGACCAGGAAAATATACTA
TCCTATGAAAACAGTTTTTCATGAGTTAGTTCAAGATTTGTTGGATATTG
ATATTGATAGTTCCAAACTTATTCTAAATCATATTATCGGAAGAGGTGCA
TTTGGAATGGTATATGGGGGTGAAGCTCTTAATGCGCACGGAATGCTTGA
AGCTGTTGCTGCTAAAACTATTAGCGAAAGCTCAAATTGGATTGAGAAAA
TTGACTTTTTCACAGAAGCCAAAGTCATGAGGAAATTAAAACATTCAAAT
ATTGTTGAATTAATTGGAGTTTGCCTAGAAAACGAAAATAATCTCATATT
TCTTATAATGGAATTAATGGTAGAAGGGGACTTAAGAAATTATCTTTTAA
GTCGTAGATCAAAAGCTGCTATTTATAGGGAAAACTCTCTAGAATCCATT
GAGTTACGTAATCGTCTGAACAGTTTTGCCAGGGATATAGCAGAAGGACT
TAATTATATGCATTCACAATTCATGGTTCATCGAGATATTGCCTGTCGTA
ATTGTTTGATTTCGCACGACTTTCATATCAAACTTGGTGATTTTGGCCTC
ACAAGATATTTAATACCTCGATGTAGTACAGGAATATATAAATTCCAAGG
AAACTTAAGTCTTCCTGTTCGGTGGATGCCACCAGAAGGAATCCAGTTTG
GAATATTTTCCATAAAGTCAGATATTTGGTCTTTCGGAATTTTATTGTTT
GAGCTTGTCACTTTTGGAGTTTGTCCTTACCAAGACTTCAGTAGTAATCA
AAATGTTGATCTTATTGATCGGATCAAAAGAAATTTATTGTCAATTATTG
ATTACCTTCCACAAAGTGCTAAAGATTCTGTTGTGCATCGATTAATCAGC
CAATGCTGTTCATATTATTCAAATAATCGCCCAGAAACAATGGAACAAAT
TATTCAAATCCTAAAATCAAATAATTCTTGTATTCGTCCTTATTTGACAG
AGGATCCACCAAAATTCGAAGGTGACAAAAATTTGGATAATTTATCAATG
AACCTTCCTGGTATTGTTATCGAAGATGATGAAGTGACGTTTACAAGTCC
TAGTGAAATGCACCTAGATTCTTCACAAAAGCGAATAAATATTATCAATC
GTGCATTCGGAATAAAATCGGTCAGTGTCAAGGAGAAAACAGATTTTCCT
GTCAGGCAACTTCGACCGTGTCAAAGTTCCGTATTTATATCCAGAAACCA
ACTTTCCGAAGAAAATATCGATTCAATGCGTATGAAAAAACCTTTGGATA
TTTTTGTCAGCTCAATTCCAACCGATCTATGCTATAACACGGGATTTCCA
AAGAAACCCAGAACCTCGACTAGATCAATGAGTAATTTTTTGAAGATATC
TCCAAAAACTTCAAATTTTAAATTAAAAATTCTTTCAAAAGATTTTCAAT
GACTTATTAAAATATATGTTATATTG

protein sequence of SMED30024446-orf-1

>SMED30024446-orf-1 ID=SMED30024446-orf-1|Name=SMED30024446-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1265bp
MNFLGLFICFFQLIVAIQLQILGDYGLCLPEKDRVNISRNIFEGIDSIFI
ESTRRSSHRIVSHIISILIRERLGYKTSIRDADWDNVTAAISRLACNKKS
CESSKPESHINMEIWMPAGFTNSEWVNRDLIIDCGPLGPIAKTGIFYFNH
ENKNYPLDDWRRLQETTRQNFPKTYHDKSVFRHFMIFGNCNDSTSSLCRT
QFAIDSKLPNRHAHVLNNLYKNWSIGSVLSDEFTKFYFTWYPNAITTQYK
MSRILFPDCKYTDSNFPDSYCDDSINQLAKIVWFGIKTKAPLIYNLVDSF
QLTQEDLVGFLKEVNISSGNIEQEYFKIACNWVLNYKAAWKPFTVGWNTT
KELYIIILLPNTDSNISQDEKNALKSALRYLNNNFSYFGSRQYKVLVKYT
NVTCEQSDIIQEYLKLVSPASEEEHHHEVGIISGLSTYCMNEIYKLTNAQ
RKIMVSFRHEIYPILARHGKNQILNISYIYQTMPSKEAYYFILEKLITTY
DWKYVTIITDTDDYRSGLNASFIHKERVYQNKKIDKALFDQFLRQNIEKL
SARIFLLDFNEADIFQILCTAGKLKMTLENGFVWIINRYFVNQSIINSFL
WCKSEIESITSNYLYLSPYIKPAVECSDFYSNNLFRAVKFLGKMVYFALK
KNPSFFEFNSDILMNYSRNVESREYFCSGKLISHSPIKMNENSFFWKVWS
LYKINGSKTTTLFEFTLSEKFHILDTYEYKLKKIQSWNPPKDASLNEDCW
VGSLTKILHVNCVIAEMLVLMTISFFILLVFIFIILIFYKYKTRKIYYPM
KTVFHELVQDLLDIDIDSSKLILNHIIGRGAFGMVYGGEALNAHGMLEAV
AAKTISESSNWIEKIDFFTEAKVMRKLKHSNIVELIGVCLENENNLIFLI
MELMVEGDLRNYLLSRRSKAAIYRENSLESIELRNRLNSFARDIAEGLNY
MHSQFMVHRDIACRNCLISHDFHIKLGDFGLTRYLIPRCSTGIYKFQGNL
SLPVRWMPPEGIQFGIFSIKSDIWSFGILLFELVTFGVCPYQDFSSNQNV
DLIDRIKRNLLSIIDYLPQSAKDSVVHRLISQCCSYYSNNRPETMEQIIQ
ILKSNNSCIRPYLTEDPPKFEGDKNLDNLSMNLPGIVIEDDEVTFTSPSE
MHLDSSQKRINIINRAFGIKSVSVKEKTDFPVRQLRPCQSSVFISRNQLS
EENIDSMRMKKPLDIFVSSIPTDLCYNTGFPKKPRTSTRSMSNFLKISPK
TSNFKLKILSKDFQ*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000101	muscle cell
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR001245	Ser-Thr/Tyr_kinase_cat_dom
IPR020635	Tyr_kinase_cat_dom
IPR001828	ANF_lig-bd_rcpt
IPR017441	Protein_kinase_ATP_BS
IPR008266	Tyr_kinase_AS
IPR000719	Prot_kinase_dom
IPR028082	Peripla_BP_I
IPR011009	Kinase-like_dom_sf

Vocabulary: **molecular function**
Term	Definition
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0000166	nucleotide binding
GO:0004383	guanylate cyclase activity
GO:0016301	kinase activity
GO:0016829	lyase activity

Vocabulary: **biological process**
Term	Definition
GO:0006468	protein phosphorylation
GO:0006182	cGMP biosynthetic process
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation

Vocabulary: **cellular component**
Term	Definition
GO:0016020	membrane
GO:0016021	integral component of membrane

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	PRINTS	PR00109	TYRKINASE	coord: 1002..1012 score: 53.58 coord: 1021..1043 score: 54.61 coord: 950..968 score: 46.25 coord: 901..914 score: 40.55
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	PFAM	PF07714	Pkinase_Tyr	coord: 823..1101 e-value: 4.7E-64 score: 216.2
IPR020635	Tyrosine-protein kinase, catalytic domain	SMART	SM00219	tyrkin_6	coord: 821..1102 e-value: 1.8E-83 score: 293.3
IPR001828	Receptor, ligand binding region	PFAM	PF01094	ANF_receptor	coord: 371..630 e-value: 5.8E-12 score: 45.4
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 903..1112 e-value: 2.2E-42 score: 146.6
None	No IPR available	GENE3D	G3DSA:3.40.50.2300		coord: 492..632 e-value: 3.5E-12 score: 48.2
None	No IPR available	GENE3D	G3DSA:3.30.200.20		coord: 788..902 e-value: 5.8E-23 score: 83.4
None	No IPR available	PANTHER	PTHR24416:SF489		coord: 738..1113
None	No IPR available	PANTHER	PTHR24416	TYROSINE-PROTEIN KINASE RECEPTOR	coord: 738..1113
None	No IPR available	CDD	cd00192	PTKc	coord: 826..1103 e-value: 1.72487E-90 score: 290.98
None	No IPR available	CDD	cd06269	PBP1_glutamate_receptors_like	coord: 355..586 e-value: 4.75703E-13 score: 69.0812
None	No IPR available	SIGNALP_EUK	SignalP-noTM	SignalP-noTM	coord: 1..16 score: 0.847
None	No IPR available	TMHMM	TMhelix		coord: 767..789
IPR017441	Protein kinase, ATP binding site	PROSITE	PS00107	PROTEIN_KINASE_ATP	coord: 827..853
IPR008266	Tyrosine-protein kinase, active site	PROSITE	PS00109	PROTEIN_KINASE_TYR	coord: 956..968
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 821..1113 score: 37.22
IPR028082	Periplasmic binding protein-like I	SUPERFAMILY	SSF53822	Periplasmic binding protein-like I	coord: 353..716
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 805..1109