Serine/threonine kinase
|
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30024442 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 11Note: Hover over icons to view figure legend
Homology
BLAST of Serine/threonine kinase vs. Ensembl Human
Match: CDC42BPA (CDC42 binding protein kinase alpha [Source:HGNC Symbol;Acc:HGNC:1737]) HSP 1 Score: 675.241 bits (1741), Expect = 0.000e+0 Identity = 501/1606 (31.20%), Postives = 803/1606 (50.00%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSV-PDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLS-HDNEIEQLKISV-------AEEQSR----------ILASNTQLKSQVKSLSEENVELRSSLQEISN--KNMKFHFRLKTILDKEIVKTSENSELLTELDREV-ELLKTLCVDNDG-----------DQKAQGERQDNNGNES----WRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQK---------------------SEICDISKQLEKYKQD-----VNEKDNLIANLKSASQNLEPHVPKEIPSNPVTLSEFNSILSGSLDKTVVNCNQ--HVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGKGA---NLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHY-RMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
MS ++ L+Q +++F+L+ + ++E L+D L C Y EC + EKN+ ++++ K K++ +R+ R DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL + WIT LHYAFQD+ LY VMD+Y GGD+LTLLSKF DRLPE++ +FY+AE+V++ID VH+L Y+HRDIKPDN+L+D GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ P + DVS+ A+DLI++LIC +E RLG GI+DFK HPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N+ PP + F G HLP +GFT+T + ++ + SL ++ L+ N + ++ + Q K+ +L ++L E T +VQ + V L K+ + + LR++ + L + N R EL QI ++ I+ L+ E+ N+L+ +A+ + K +E+ +H S Q ++ ++ + + + E+ Q + K++ LE+ ++IF +EE+ + I N+ KNLK HD+E +QL ++ E++R Q + + L+EEN +L S L +++ +N+ H L++E+ ++ E + + ++ E+++ + + D ++ + R + G + W++R+ K D L L +E RA+ ++++L + K SEI + K E+ + + + + + +A L + + L+ + + S P+++ G T + H F +F P KC CTS M+G QG C+ C FSCH C+ N C KG + + GIGT YE +++PKP G+++GW+R +CD KLF +D+ EG IS +VID++ EF V V +V+HA +KD+ I +++ + S+ I +L ++ + K + V+ E +KK+ R ++ K ++ + Q +AAIID + G EEGL + VT ++G+ K ++ IE + QLVAVI + R ++L LDG + + + K C T GK + + +C A K V Y L TRH K ++I +V + I EQL +G Y L G+P + L D +I +++ VEIS EYL+ F GI+ + R++R +L WP P+ Y APYL ++E A + +++ +S +Q LPL+ +PL+ G + ++ I LIY A +++ + +T D + +I NKR+ S+ P + RD P ++ N+ IS P NF H++HMGP Q++
Sbjct: 1 MSGEVRLRQ-----LEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---DNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKL---ELSRKLQES-TQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIK-TLQQEREDLNKLEVHTEAL-----------AAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSI--EHQQEITKLK-------TDLEK--KSIF-YEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIH---NQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTPTDALDQF--ETVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCV-NKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVIS----QVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQ--AAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPND--QLVAVISGRNRHVRLFPMSALDG-RETDFYKLSETKGCQTVTSGKV--------------------------RHGALTCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAI--FSEQLCVGFQSGFLRYPLNGEGNP----YSMLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENA-VDIFDV--NSMEWIQTLPLKKVRPLNNEGSLNLLG---LETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNIN---NKRRYSFRV--------------PEEERMQQRREMLRD-PEMR-NKLISNPTNFNHIAHMGPGDGIQIL 1498
BLAST of Serine/threonine kinase vs. Ensembl Human
Match: CDC42BPB (CDC42 binding protein kinase beta [Source:HGNC Symbol;Acc:HGNC:1738]) HSP 1 Score: 629.017 bits (1621), Expect = 0.000e+0 Identity = 502/1703 (29.48%), Postives = 823/1703 (48.33%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD--FNANHEGPPLS-SNFKGCHLPCIGFTFTKDFIFNEMGSEES-------------------SVRLKSLMENI-------------------------GAPALLNGNHNESNSDALLEEVNQLK---ITCSQLEKQLNEC------RTNSVQRIFS----HPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNRL-------LNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXH--------------LSIQKN--------QSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQL-----------KISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKF-HFRLKTILDKEIVKTSENSE-----LLTELDREVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARA--------------DLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIANLK---------------------------SASQNLEPHVPKEIPSNPVTLSEFNSILS--------------GSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGK---GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHYRMIFTEKSCLNNLDISMNY-RQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRP-DLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGK-TIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQ-LIDL 4618
MS K+ LK+ +++ LL+ ++++E L+D L C Y EC + +K VA+F++ K ++ +++ R DF+ I+VIGRGAFG+V+VV+ K IYAMK L+K+++LK+ + ACF+EERDVL WIT LHYAFQDE +LY VMD+Y GGD+LTLLSKF D+LPE++ +FYI E+V++ID +H+L Y+HRDIKPDN+LLD GHI LADFGSC+K+ +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN E FQ P+ DVS+EA+DLI++LIC +E RLG GI+DFK H FF ++W+N+R+ AP+IP+VSS DTSNF+ DD PP S + F G HLP IGFTFT + F++ GS +S S+++++ I G+ L+ ++ + L EE+ +LK ++LE+QL + R +S QR+ H V +Q +KE+L Q L+ + +++ D + +L LN+ EL + + ++ ++ +D EE+++V T+ + ++ + + + LE +LD + KE++ +H L +++ + Q +I K E+ +L E + L+ N+ + S+ +++EI LK+ EK+ + H NE+E+ + + +E ++ A N +L S V L+ +N +L LQ+++ K H+ + + V +++ L +++ E+E L++ + G R + W++R+ K D L L++E RA+ LE KL +++ ++ +++E K+ + EK LK ++ Q + P+ PS V SE ++ +L H FS +F+ P +C +CTS M+G QG C+ CSF+CH C C K G +++ GIGT Y+ +KVPKP G+++GW+R + +CD KLF +D+ EG + TQ I+ +V+DL+ EF V V +V+HA ++D+ I +++ + S + +L E+ + K + ++E +S + K+ + L D S+ + IL+AAI+D + G EEGL ++VT + + K V+ IE ++ ++V ++ + + L LDGA I + K C ++A +T S + + A K + Y + H K +I+ SV L + ++L +G + S+ G P + D + ++ Q +F+++ VE+ EYL+ F G++++ R+ R +L WP P + ++ ++E G+ +++ + VQ + LR +PL+ G L N + LIY + K S + TS ++ + + +KR+ + P + RD P L+S + IS P NF H++HMGP Q L+DL
Sbjct: 1 MSAKVRLKK-----LEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNG---DCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALSNSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVVRQ---EKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRDKEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQGGRGAGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQLALQKEILMLKDKL---EKSKRERH-NEMEEAVGTIKDKYERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELEALRSSSL---------GSR---TLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNTAPLAHDLTFRTSSASEQETQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPTTQALALAGPKPKAHQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGA-PQVCPIPPEQSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKS-TQPGVIA---SQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTENENEKRKWVGILEGLQSILHKNRLRNQVV--HVPLEAYDSSLPLIKAILTAAIVDADRIAVGLEEGLYVIEVTRDVIVRAADCKKVHQIELAPRE--KIVILLCGRNHHVHLYPWSSLDGAEGSFDIKLPETKGC---------------------QLMATATLKRNSGT-----CLFVAVKRLILCYEIQRTKPFHRKFNEIVAPGSVQCLAVL--RDRLCVGYPSGFCLLSIQGDGQP----LNLVNPNDPSLAFLSQQSFDALCAVELESEEYLLCFSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVYSEY-GVDVFDV--RTMEWVQTIGLRRIRPLNSEG-TLNLLN--CEPPRLIYF------KSKFSGAVLNVPDTSDNSKKQMLRTRSKRRFVFKV--------------PEEERLQQRREMLRD-PELRS-KMISNPTNFNHVAHMGPGDGMQVLMDL 1607
BLAST of Serine/threonine kinase vs. Ensembl Human
Match: CDC42BPA (CDC42 binding protein kinase alpha [Source:HGNC Symbol;Acc:HGNC:1737]) HSP 1 Score: 464.537 bits (1194), Expect = 6.784e-135 Identity = 247/578 (42.73%), Postives = 362/578 (62.63%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSV-PDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKE--------------KLLTQCQNYDYSLREK---EQKMDDLI-------ETNRLLNKERDELTSDRLQILQKKQDIEEDLK 1678
MS ++ L+Q +++F+L+ + ++E L+D L C Y EC + EKN+ ++++ K K++ +R+ R DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL + WIT LHYAFQD+ LY VMD+Y GGD+LTLLSKF DRLPE++ +FY+AE+V++ID VH+L Y+HRDIKPDN+L+D GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ P + DVS+ A+DLI++LIC +E RLG GI+DFK HPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N+ PP + F G HLP +GFT+T + ++ + SL ++ L+ N + ++ + Q K+ +L ++L E T +VQ + V L K+ K +T+ + + L E Q++DD + + L +ER++L + +Q ++ ++ ++LK
Sbjct: 1 MSGEVRLRQ-----LEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---DNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKL---ELSRKLQES-TQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELK 566 HSP 2 Score: 243.817 bits (621), Expect = 4.379e-64 Identity = 245/946 (25.90%), Postives = 419/946 (44.29%), Query Frame = 2
Query: 1931 SNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLS-HDNEIEQLKISV-------AEEQSR----------ILASNTQLKSQVKSLSEENVELRSSLQEISN--KNMKFHFRLKTILDKEIVKTSENSELLTELDREV-ELLKTLCVDNDG-----------DQKAQGERQDNNGNES----WRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSE----ICDISKQLEKYKQDVNEKDNLIANLKSASQNLEPHVPKEIPSNPVTLSEFNSILSGSLDKTVVNCNQ--HVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGKGA---NLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHY-RMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
+ L LE+ ++IF +EE+ + I N+ KNLK HD+E +QL ++ E++R Q + + L+EEN +L S L +++ +N+ H L++E+ ++ E + + ++ E+++ + + D ++ + R + G + W++R+ K D L L +E RA+ ++++L + K+ C + +K + ++E + LI + + + + S P+++ G T + H F +F P KC CTS M+G QG C+ C FSCH C+ N C KG + + GIGT YE +++PKP G+++GW+R +CD KLF +D+ EG IS +VID++ EF V V +V+HA +KD+ I +++ + S+ I +L ++ + K + V+ E +KK+ R ++ K ++ + Q +AAIID + G EEGL + VT ++G+ K ++ IE + QLVAVI + R ++L LDG + + + K C T GK V G + +C A K V Y L TRH K ++I +V + I EQL +G Y L G+P + L D +I +++ VEIS EYL+ F GI+ + R++R +L WP P+ Y APYL ++E A + +++ +S +Q LPL+ +PL+ G + ++ I LIY A +++ + +T D + +I NKR+ S+ P + RD P ++ N+ IS P NF H++HMGP Q++
Sbjct: 687 TKLKTDLEK--KSIF-YEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIH---NQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKASKGRRTVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCV-NKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVIS----QVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQ--AAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPND--QLVAVISGRNRHVRLFPMSALDG-RETDFYKLSETKGCQTVTSGK--VRHGA------------------------LTCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAI--FSEQLCVGFQSGFLRYPLNGEGNP----YSMLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENA-VDIFDV--NSMEWIQTLPLKKVRPLNNEGSLNLLG---LETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNIN---NKRRYSFRV--------------PEEERMQQRREMLRD-PEMR-NKLISNPTNFNHIAHMGPGDGIQIL 1559
BLAST of Serine/threonine kinase vs. Ensembl Human
Match: CDC42BPA (CDC42 binding protein kinase alpha [Source:HGNC Symbol;Acc:HGNC:1737]) HSP 1 Score: 464.151 bits (1193), Expect = 1.047e-134 Identity = 247/578 (42.73%), Postives = 362/578 (62.63%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSV-PDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKE--------------KLLTQCQNYDYSLREK---EQKMDDLI-------ETNRLLNKERDELTSDRLQILQKKQDIEEDLK 1678
MS ++ L+Q +++F+L+ + ++E L+D L C Y EC + EKN+ ++++ K K++ +R+ R DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL + WIT LHYAFQD+ LY VMD+Y GGD+LTLLSKF DRLPE++ +FY+AE+V++ID VH+L Y+HRDIKPDN+L+D GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ P + DVS+ A+DLI++LIC +E RLG GI+DFK HPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N+ PP + F G HLP +GFT+T + ++ + SL ++ L+ N + ++ + Q K+ +L ++L E T +VQ + V L K+ K +T+ + + L E Q++DD + + L +ER++L + +Q ++ ++ ++LK
Sbjct: 1 MSGEVRLRQ-----LEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---DNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKL---ELSRKLQES-TQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELK 566 HSP 2 Score: 237.654 bits (605), Expect = 4.049e-62 Identity = 188/647 (29.06%), Postives = 295/647 (45.60%), Query Frame = 2
Query: 2702 HVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGKGA---NLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHY-RMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
H F +F P KC CTS M+G QG C+ C FSCH C+ N C KG + + GIGT YE +++PKP G+++GW+R +CD KLF +D+ EG IS +VID++ EF V V +V+HA +KD+ I +++ + S+ I +L ++ + K + V+ E +KK+ R ++ K ++ + Q +AAIID + G EEGL + VT ++G+ K ++ IE + QLVAVI + R ++L LDG + + + K C T GK V G + +C A K V Y L TRH K ++I +V + I EQL +G Y L G+P + L D +I +++ VEIS EYL+ F GI+ + R++R +L WP P+ Y APYL ++E A + +++ +S +Q LPL+ +PL+ G + ++ I LIY A +++ + +T D + +I NKR+ S+ P + RD P ++ N+ IS P NF H++HMGP Q++
Sbjct: 1000 HQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCV-NKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVIS----QVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQ--AAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPND--QLVAVISGRNRHVRLFPMSALDG-RETDFYKLSETKGCQTVTSGK--VRHGA------------------------LTCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAI--FSEQLCVGFQSGFLRYPLNGEGNP----YSMLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENA-VDIFDV--NSMEWIQTLPLKKVRPLNNEGSLNLLG---LETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNIN---NKRRYSFRV--------------PEEERMQQRREMLRD-PEMR-NKLISNPTNFNHIAHMGPGDGIQIL 1579
BLAST of Serine/threonine kinase vs. Ensembl Human
Match: CDC42BPA (CDC42 binding protein kinase alpha [Source:HGNC Symbol;Acc:HGNC:1737]) HSP 1 Score: 464.151 bits (1193), Expect = 1.453e-134 Identity = 247/578 (42.73%), Postives = 362/578 (62.63%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSV-PDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKE--------------KLLTQCQNYDYSLREK---EQKMDDLI-------ETNRLLNKERDELTSDRLQILQKKQDIEEDLK 1678
MS ++ L+Q +++F+L+ + ++E L+D L C Y EC + EKN+ ++++ K K++ +R+ R DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL + WIT LHYAFQD+ LY VMD+Y GGD+LTLLSKF DRLPE++ +FY+AE+V++ID VH+L Y+HRDIKPDN+L+D GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ P + DVS+ A+DLI++LIC +E RLG GI+DFK HPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N+ PP + F G HLP +GFT+T + ++ + SL ++ L+ N + ++ + Q K+ +L ++L E T +VQ + V L K+ K +T+ + + L E Q++DD + + L +ER++L + +Q ++ ++ ++LK
Sbjct: 1 MSGEVRLRQ-----LEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---DNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKL---ELSRKLQES-TQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELK 566 HSP 2 Score: 237.269 bits (604), Expect = 5.431e-62 Identity = 188/647 (29.06%), Postives = 295/647 (45.60%), Query Frame = 2
Query: 2702 HVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGKGA---NLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHY-RMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
H F +F P KC CTS M+G QG C+ C FSCH C+ N C KG + + GIGT YE +++PKP G+++GW+R +CD KLF +D+ EG IS +VID++ EF V V +V+HA +KD+ I +++ + S+ I +L ++ + K + V+ E +KK+ R ++ K ++ + Q +AAIID + G EEGL + VT ++G+ K ++ IE + QLVAVI + R ++L LDG + + + K C T GK V G + +C A K V Y L TRH K ++I +V + I EQL +G Y L G+P + L D +I +++ VEIS EYL+ F GI+ + R++R +L WP P+ Y APYL ++E A + +++ +S +Q LPL+ +PL+ G + ++ I LIY A +++ + +T D + +I NKR+ S+ P + RD P ++ N+ IS P NF H++HMGP Q++
Sbjct: 1013 HQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCV-NKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVIS----QVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQ--AAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPND--QLVAVISGRNRHVRLFPMSALDG-RETDFYKLSETKGCQTVTSGK--VRHGA------------------------LTCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAI--FSEQLCVGFQSGFLRYPLNGEGNP----YSMLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENA-VDIFDV--NSMEWIQTLPLKKVRPLNNEGSLNLLG---LETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNIN---NKRRYSFRV--------------PEEERMQQRREMLRD-PEMR-NKLISNPTNFNHIAHMGPGDGIQIL 1592
BLAST of Serine/threonine kinase vs. Ensembl Celegans
Match: mrck-1 (Serine/threonine-protein kinase mrck-1 [Source:UniProtKB/Swiss-Prot;Acc:O01583]) HSP 1 Score: 626.32 bits (1614), Expect = 0.000e+0 Identity = 488/1629 (29.96%), Postives = 806/1629 (49.48%), Query Frame = 2
Query: 74 IKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDD--VSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFD----DFNANHEGPP-LSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNY---------DYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQP----------DIQVEK----QRFEEVMLQLRS--ENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQ--------LKSQVKSLSEENVEL-RSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKT---LCVDN--DGDQKAQGERQDNN--GNESWRLRKCVKAD-------KIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQL-------EKYKQDVNEKDNLIANLKSASQNLEPHVPKEIPSNPVTLSEFNSIL-----------------------SGSLDKTVVNCNQ--HVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGK--GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIEN-------SSTMLPIYVLF--ESVDNKEDCIKVIEEARSYIKKDPHY-RMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFG-TEEGLLKVTDS-------GYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLW-----ETGSPXXXXXXXXXXXXXN-----FQYI-FQTNFESMLIVEI--SFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTE-MAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGP 4591
++ ++ S P++++ E LIDSL C Y EC + EK +A+F++S+K + K + LR+ R DF+ ++VIG+GAFG+V+VVR + GEIYAMK L+K++++K+ + ACF+EERDVL + WIT LHYAFQDE LYFVMD+Y GGDMLTLLSKF D +PE + KFYIAE+V++ID +H+LGY+HRD+KPDN+LLD GHI LADFGSC+++ +G+ + AVGTPDYISPEILR+ E G G YG ECDWWSLGI ++EMLYG PFY+E +TY +IM+ + P + D VS+EA+DLI+QLIC + R G G+ DF+ HPFF IDW+ +R N P++PEVSS EDTSNF+ D DF PP + + F G HLP +GF++T + ++ S +R ++ + A L E + D + E+ K ++L ++L E +T Q + +P ++ + E + Q ++ D +L +++QK D I K+ EL Q++ +K +I+ +L + ++ +Q+ + +++D ++ EL + + EK+ +K L + +++ +I+ EK ++ EEV ++ R E D L + + N SL+ +++ + EIK LK+ + + + E++QL+ E ++L N + L+ +++ LS++ L R L E + H + + +E E L ++ EVE LK L N G R+ NN + L++ ++A+ K E+ N + D EK++ E+ + +Q + + D +I+ + + +E+ S T S N+IL SG ++ + H F P KC +CTS ++G QG+ C+ C ++CH C V + C + + G + G+GT YE +K P+ GG+R+GW+ ++ +CD KL+ +D +M D+ V+D++ +F V VS +V+HA K D+ I +++ S+ Y LF E+ + K + + E ++ +++ R F K + + + R AIID+S ++ G ++ GL + S G K +++ V +E + ++L ++ V +K R ++++ S LDG D + I V + K C VG + +PG + +A AFK SV ++ ++ RH+K + + + S+ I +L +G S +SL GS +N Q++ QT++E+ LIV + S +EYL++F G+++N R++R P++ +P + F Y PYL F+E +F + E VQ + LRS+KPL G IL+T + I+V L + +++ SI ++ S S + + +RK ++ ++ G R +S+ QIS P +F H+ HMGP
Sbjct: 17 LENIYMDGPSKKPEALSFETLIDSLICLYDECCNSTLRKEKCIAEFVESVKTVISKAKKLRLSRDDFEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDR---RWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPESMAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMEDGRGRYGKECDWWSLGICMYEMLYGTTPFYSERLVDTYGKIMSHQDMLDFPDDEIDWVVSEEAKDLIRQLICSSDVRFGRNGLSDFQLHPFFEGIDWNTIRDSNPPYVPEVSSPEDTSNFDVDVCEDDFTPCETQPPRVLAAFTGNHLPFVGFSYTHGSLLSDARSLTDEIR--AIAQRCQGDAELM----EKSVDGFMVELENEK---AELVQKLKEAQTIIAQHVAENPRSEE-DRNYESTIAQLKDEIQILNKRLEDEALAQQQQKPKDEIVAES--EKKLKELKERNKQLVMEKSEIQRELDNINDHLDQVLVEKATVVQQRDDMQAELADVGDSLLTEKDSVKRLQDEAEKAKKQVADFEEKLKEIETEKIALIKKQEEVTIEARKSVETDDHLSEEVVAAKNTIASLQATNE---ERETEIKKLKQRMDEERASHTAQSEQEMKQLEAHY-ERAQKMLQDNVEQMNVENRGLRDEIEKLSQQMAALPRGGLNE-----QQLH-EIFNWVSEEKATREEMENLTRKITGEVESLKNNSPLTTSNYIQNTPSGWGSRRMNNVARKDGLDLQRQLQAEIDAKLKLKAELKNSQEQYLTSAARLDDTEKRMASLMREVAMLKQQKNIENSSDSAFSSTMGRGDLMISMNNDYEMSNSSLMRQEMISRQSTPSYENAILLHDHQVPKRVDDLRYKQKPMKTASGIFSPVSISAMERGHNFERMKIKTPTKCGHCTSILIGLDRQGLFCQSCQYACHVSCAERV-SQSCPVPEEERRPLGIDPTRGVGTAYEGLVKTPRAGGVRKGWQTAYVVVCDFKLYLYDCTVDRQ-NKMQDVKNEIRLVLDMRDPDFTVCGVSEADVIHAQKGDIPKIFRVTTTQILNSSSEYSSSSKFYTLFMAETEEEKRKWVVALSELKTLLRRSKLADRKAFLVKEVFDVTTLP-SIRVAQCCAIIDRSKIVIGFSDHGLYCIEISRQLLIPVGGEKENKQRCVETVEYDEAEQLLMMIVGPAKDRHVRIVPSAALDG-RDLKWIKVNDTKGCHLLAVGTN--NPGGRAGFFA-----------------------VAFKKSVTIFQIDRSEKRHKKWKDLAMPGTPQSIAI--FNGRLYVGFSHSFRSWSLVGVDSSPVGSGDASGAVLQHISLVNMEDTSLQFLNQQTSYEAKLIVNVPGSPDEYLLVFNMIGLYVNEMGRRSRLPEVMFPTQAKYFAYHEPYLCVFSENEVDIFNVTLAE----WVQTINLRSAKPLSGDG-ILSTC---LCNDSPIFVLLQNVLQDQDSIEVPVNLASGSTD---GRKVTRRKFTF----------------------RTIGKDDRSASERRSHIQISTPSDFMHIVHMGP 1556
BLAST of Serine/threonine kinase vs. Ensembl Celegans
Match: mrck-1 (Serine/threonine-protein kinase mrck-1 [Source:UniProtKB/Swiss-Prot;Acc:O01583]) HSP 1 Score: 626.32 bits (1614), Expect = 0.000e+0 Identity = 488/1629 (29.96%), Postives = 806/1629 (49.48%), Query Frame = 2
Query: 74 IKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDD--VSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFD----DFNANHEGPP-LSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNY---------DYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQP----------DIQVEK----QRFEEVMLQLRS--ENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQ--------LKSQVKSLSEENVEL-RSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKT---LCVDN--DGDQKAQGERQDNN--GNESWRLRKCVKAD-------KIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQL-------EKYKQDVNEKDNLIANLKSASQNLEPHVPKEIPSNPVTLSEFNSIL-----------------------SGSLDKTVVNCNQ--HVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGK--GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIEN-------SSTMLPIYVLF--ESVDNKEDCIKVIEEARSYIKKDPHY-RMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFG-TEEGLLKVTDS-------GYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLW-----ETGSPXXXXXXXXXXXXXN-----FQYI-FQTNFESMLIVEI--SFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTE-MAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGP 4591
++ ++ S P++++ E LIDSL C Y EC + EK +A+F++S+K + K + LR+ R DF+ ++VIG+GAFG+V+VVR + GEIYAMK L+K++++K+ + ACF+EERDVL + WIT LHYAFQDE LYFVMD+Y GGDMLTLLSKF D +PE + KFYIAE+V++ID +H+LGY+HRD+KPDN+LLD GHI LADFGSC+++ +G+ + AVGTPDYISPEILR+ E G G YG ECDWWSLGI ++EMLYG PFY+E +TY +IM+ + P + D VS+EA+DLI+QLIC + R G G+ DF+ HPFF IDW+ +R N P++PEVSS EDTSNF+ D DF PP + + F G HLP +GF++T + ++ S +R ++ + A L E + D + E+ K ++L ++L E +T Q + +P ++ + E + Q ++ D +L +++QK D I K+ EL Q++ +K +I+ +L + ++ +Q+ + +++D ++ EL + + EK+ +K L + +++ +I+ EK ++ EEV ++ R E D L + + N SL+ +++ + EIK LK+ + + + E++QL+ E ++L N + L+ +++ LS++ L R L E + H + + +E E L ++ EVE LK L N G R+ NN + L++ ++A+ K E+ N + D EK++ E+ + +Q + + D +I+ + + +E+ S T S N+IL SG ++ + H F P KC +CTS ++G QG+ C+ C ++CH C V + C + + G + G+GT YE +K P+ GG+R+GW+ ++ +CD KL+ +D +M D+ V+D++ +F V VS +V+HA K D+ I +++ S+ Y LF E+ + K + + E ++ +++ R F K + + + R AIID+S ++ G ++ GL + S G K +++ V +E + ++L ++ V +K R ++++ S LDG D + I V + K C VG + +PG + +A AFK SV ++ ++ RH+K + + + S+ I +L +G S +SL GS +N Q++ QT++E+ LIV + S +EYL++F G+++N R++R P++ +P + F Y PYL F+E +F + E VQ + LRS+KPL G IL+T + I+V L + +++ SI ++ S S + + +RK ++ ++ G R +S+ QIS P +F H+ HMGP
Sbjct: 17 LENIYMDGPSKKPEALSFETLIDSLICLYDECCNSTLRKEKCIAEFVESVKTVISKAKKLRLSRDDFEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDR---RWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPESMAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMEDGRGRYGKECDWWSLGICMYEMLYGTTPFYSERLVDTYGKIMSHQDMLDFPDDEIDWVVSEEAKDLIRQLICSSDVRFGRNGLSDFQLHPFFEGIDWNTIRDSNPPYVPEVSSPEDTSNFDVDVCEDDFTPCETQPPRVLAAFTGNHLPFVGFSYTHGSLLSDARSLTDEIR--AIAQRCQGDAELM----EKSVDGFMVELENEK---AELVQKLKEAQTIIAQHVAENPRSEE-DRNYESTIAQLKDEIQILNKRLEDEALAQQQQKPKDEIVAES--EKKLKELKERNKQLVMEKSEIQRELDNINDHLDQVLVEKATVVQQRDDMQAELADVGDSLLTEKDSVKRLQDEAEKAKKQVADFEEKLKEIETEKIALIKKQEEVTIEARKSVETDDHLSEEVVAAKNTIASLQATNE---ERETEIKKLKQRMDEERASHTAQSEQEMKQLEAHY-ERAQKMLQDNVEQMNVENRGLRDEIEKLSQQMAALPRGGLNE-----QQLH-EIFNWVSEEKATREEMENLTRKITGEVESLKNNSPLTTSNYIQNTPSGWGSRRMNNVARKDGLDLQRQLQAEIDAKLKLKAELKNSQEQYLTSAARLDDTEKRMASLMREVAMLKQQKNIENSSDSAFSSTMGRGDLMISMNNDYEMSNSSLMRQEMISRQSTPSYENAILLHDHQVPKRVDDLRYKQKPMKTASGIFSPVSISAMERGHNFERMKIKTPTKCGHCTSILIGLDRQGLFCQSCQYACHVSCAERV-SQSCPVPEEERRPLGIDPTRGVGTAYEGLVKTPRAGGVRKGWQTAYVVVCDFKLYLYDCTVDRQ-NKMQDVKNEIRLVLDMRDPDFTVCGVSEADVIHAQKGDIPKIFRVTTTQILNSSSEYSSSSKFYTLFMAETEEEKRKWVVALSELKTLLRRSKLADRKAFLVKEVFDVTTLP-SIRVAQCCAIIDRSKIVIGFSDHGLYCIEISRQLLIPVGGEKENKQRCVETVEYDEAEQLLMMIVGPAKDRHVRIVPSAALDG-RDLKWIKVNDTKGCHLLAVGTN--NPGGRAGFFA-----------------------VAFKKSVTIFQIDRSEKRHKKWKDLAMPGTPQSIAI--FNGRLYVGFSHSFRSWSLVGVDSSPVGSGDASGAVLQHISLVNMEDTSLQFLNQQTSYEAKLIVNVPGSPDEYLLVFNMIGLYVNEMGRRSRLPEVMFPTQAKYFAYHEPYLCVFSENEVDIFNVTLAE----WVQTINLRSAKPLSGDG-ILSTC---LCNDSPIFVLLQNVLQDQDSIEVPVNLASGSTD---GRKVTRRKFTF----------------------RTIGKDDRSASERRSHIQISTPSDFMHIVHMGP 1556
BLAST of Serine/threonine kinase vs. Ensembl Celegans
Match: mrck-1 (Serine/threonine-protein kinase mrck-1 [Source:UniProtKB/Swiss-Prot;Acc:O01583]) HSP 1 Score: 623.239 bits (1606), Expect = 0.000e+0 Identity = 487/1631 (29.86%), Postives = 806/1631 (49.42%), Query Frame = 2
Query: 74 IKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDD--VSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFD----DFNA---NHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNY---------DYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQP----------DIQVEK----QRFEEVMLQLRS--ENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQ--------LKSQVKSLSEENVEL-RSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKT---LCVDN--DGDQKAQGERQDNN--GNESWRLRKCVKAD-------KIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQL-------EKYKQDVNEKDNLIANLKSASQNLEPHVPKEIPSNPVTLSEFNSIL-----------------------SGSLDKTVVNCNQ--HVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGK--GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIEN-------SSTMLPIYVLF--ESVDNKEDCIKVIEEARSYIKKDPHY-RMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFG-TEEGLLKVTDS-------GYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLW-----ETGSPXXXXXXXXXXXXXN-----FQYI-FQTNFESMLIVEI--SFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTE-MAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGP 4591
++ ++ S P++++ E LIDSL C Y EC + EK +A+F++S+K + K + LR+ R DF+ ++VIG+GAFG+V+VVR + GEIYAMK L+K++++K+ + ACF+EERDVL + WIT LHYAFQDE LYFVMD+Y GGDMLTLLSKF D +PE + KFYIAE+V++ID +H+LGY+HRD+KPDN+LLD GHI LADFGSC+++ +G+ + AVGTPDYISPEILR+ E G G YG ECDWWSLGI ++EMLYG PFY+E +TY +IM+ + P + D VS+EA+DLI+QLIC + R G G+ DF+ HPFF IDW+ +R N P++PEVSS EDTSNF+ D DF + P + + F G HLP +GF++T + ++ S +R ++ + A L E + D + E+ K ++L ++L E +T Q + +P ++ + E + Q ++ D +L +++QK D I K+ EL Q++ +K +I+ +L + ++ +Q+ + +++D ++ EL + + EK+ +K L + +++ +I+ EK ++ EEV ++ R E D L + + N SL+ +++ + EIK LK+ + + + E++QL+ E ++L N + L+ +++ LS++ L R L E + H + + +E E L ++ EVE LK L N G R+ NN + L++ ++A+ K E+ N + D EK++ E+ + +Q + + D +I+ + + +E+ S T S N+IL SG ++ + H F P KC +CTS ++G QG+ C+ C ++CH C V + C + + G + G+GT YE +K P+ GG+R+GW+ ++ +CD KL+ +D +M D+ V+D++ +F V VS +V+HA K D+ I +++ S+ Y LF E+ + K + + E ++ +++ R F K + + + R AIID+S ++ G ++ GL + S G K +++ V +E + ++L ++ V +K R ++++ S LDG D + I V + K C VG + +PG + +A AFK SV ++ ++ RH+K + + + S+ I +L +G S +SL GS +N Q++ QT++E+ LIV + S +EYL++F G+++N R++R P++ +P + F Y PYL F+E +F + E VQ + LRS+KPL G IL+T + I+V L + +++ SI ++ S S + + +RK ++ ++ G R +S+ QIS P +F H+ HMGP
Sbjct: 17 LENIYMDGPSKKPEALSFETLIDSLICLYDECCNSTLRKEKCIAEFVESVKTVISKAKKLRLSRDDFEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDR---RWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPESMAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMEDGRGRYGKECDWWSLGICMYEMLYGTTPFYSERLVDTYGKIMSHQDMLDFPDDEIDWVVSEEAKDLIRQLICSSDVRFGRNGLSDFQLHPFFEGIDWNTIRDSNPPYVPEVSSPEDTSNFDVDVCEDDFTPCLQETQPPRVLAAFTGNHLPFVGFSYTHGSLLSDARSLTDEIR--AIAQRCQGDAELM----EKSVDGFMVELENEK---AELVQKLKEAQTIIAQHVAENPRSEE-DRNYESTIAQLKDEIQILNKRLEDEALAQQQQKPKDEIVAES--EKKLKELKERNKQLVMEKSEIQRELDNINDHLDQVLVEKATVVQQRDDMQAELADVGDSLLTEKDSVKRLQDEAEKAKKQVADFEEKLKEIETEKIALIKKQEEVTIEARKSVETDDHLSEEVVAAKNTIASLQATNE---ERETEIKKLKQRMDEERASHTAQSEQEMKQLEAHY-ERAQKMLQDNVEQMNVENRGLRDEIEKLSQQMAALPRGGLNE-----QQLH-EIFNWVSEEKATREEMENLTRKITGEVESLKNNSPLTTSNYIQNTPSGWGSRRMNNVARKDGLDLQRQLQAEIDAKLKLKAELKNSQEQYLTSAARLDDTEKRMASLMREVAMLKQQKNIENSSDSAFSSTMGRGDLMISMNNDYEMSNSSLMRQEMISRQSTPSYENAILLHDHQVPKRVDDLRYKQKPMKTASGIFSPVSISAMERGHNFERMKIKTPTKCGHCTSILIGLDRQGLFCQSCQYACHVSCAERV-SQSCPVPEEERRPLGIDPTRGVGTAYEGLVKTPRAGGVRKGWQTAYVVVCDFKLYLYDCTVDRQ-NKMQDVKNEIRLVLDMRDPDFTVCGVSEADVIHAQKGDIPKIFRVTTTQILNSSSEYSSSSKFYTLFMAETEEEKRKWVVALSELKTLLRRSKLADRKAFLVKEVFDVTTLP-SIRVAQCCAIIDRSKIVIGFSDHGLYCIEISRQLLIPVGGEKENKQRCVETVEYDEAEQLLMMIVGPAKDRHVRIVPSAALDG-RDLKWIKVNDTKGCHLLAVGTN--NPGGRAGFFA-----------------------VAFKKSVTIFQIDRSEKRHKKWKDLAMPGTPQSIAI--FNGRLYVGFSHSFRSWSLVGVDSSPVGSGDASGAVLQHISLVNMEDTSLQFLNQQTSYEAKLIVNVPGSPDEYLLVFNMIGLYVNEMGRRSRLPEVMFPTQAKYFAYHEPYLCVFSENEVDIFNVTLAE----WVQTINLRSAKPLSGDG-ILSTC---LCNDSPIFVLLQNVLQDQDSIEVPVNLASGSTD---GRKVTRRKFTF----------------------RTIGKDDRSASERRSHIQISTPSDFMHIVHMGP 1558
BLAST of Serine/threonine kinase vs. Ensembl Celegans
Match: mrck-1 (Serine/threonine-protein kinase mrck-1 [Source:UniProtKB/Swiss-Prot;Acc:O01583]) HSP 1 Score: 623.239 bits (1606), Expect = 0.000e+0 Identity = 487/1631 (29.86%), Postives = 806/1631 (49.42%), Query Frame = 2
Query: 74 IKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDD--VSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFD----DFNA---NHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNY---------DYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQP----------DIQVEK----QRFEEVMLQLRS--ENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQ--------LKSQVKSLSEENVEL-RSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKT---LCVDN--DGDQKAQGERQDNN--GNESWRLRKCVKAD-------KIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQL-------EKYKQDVNEKDNLIANLKSASQNLEPHVPKEIPSNPVTLSEFNSIL-----------------------SGSLDKTVVNCNQ--HVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGK--GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIEN-------SSTMLPIYVLF--ESVDNKEDCIKVIEEARSYIKKDPHY-RMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFG-TEEGLLKVTDS-------GYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLW-----ETGSPXXXXXXXXXXXXXN-----FQYI-FQTNFESMLIVEI--SFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTE-MAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGP 4591
++ ++ S P++++ E LIDSL C Y EC + EK +A+F++S+K + K + LR+ R DF+ ++VIG+GAFG+V+VVR + GEIYAMK L+K++++K+ + ACF+EERDVL + WIT LHYAFQDE LYFVMD+Y GGDMLTLLSKF D +PE + KFYIAE+V++ID +H+LGY+HRD+KPDN+LLD GHI LADFGSC+++ +G+ + AVGTPDYISPEILR+ E G G YG ECDWWSLGI ++EMLYG PFY+E +TY +IM+ + P + D VS+EA+DLI+QLIC + R G G+ DF+ HPFF IDW+ +R N P++PEVSS EDTSNF+ D DF + P + + F G HLP +GF++T + ++ S +R ++ + A L E + D + E+ K ++L ++L E +T Q + +P ++ + E + Q ++ D +L +++QK D I K+ EL Q++ +K +I+ +L + ++ +Q+ + +++D ++ EL + + EK+ +K L + +++ +I+ EK ++ EEV ++ R E D L + + N SL+ +++ + EIK LK+ + + + E++QL+ E ++L N + L+ +++ LS++ L R L E + H + + +E E L ++ EVE LK L N G R+ NN + L++ ++A+ K E+ N + D EK++ E+ + +Q + + D +I+ + + +E+ S T S N+IL SG ++ + H F P KC +CTS ++G QG+ C+ C ++CH C V + C + + G + G+GT YE +K P+ GG+R+GW+ ++ +CD KL+ +D +M D+ V+D++ +F V VS +V+HA K D+ I +++ S+ Y LF E+ + K + + E ++ +++ R F K + + + R AIID+S ++ G ++ GL + S G K +++ V +E + ++L ++ V +K R ++++ S LDG D + I V + K C VG + +PG + +A AFK SV ++ ++ RH+K + + + S+ I +L +G S +SL GS +N Q++ QT++E+ LIV + S +EYL++F G+++N R++R P++ +P + F Y PYL F+E +F + E VQ + LRS+KPL G IL+T + I+V L + +++ SI ++ S S + + +RK ++ ++ G R +S+ QIS P +F H+ HMGP
Sbjct: 17 LENIYMDGPSKKPEALSFETLIDSLICLYDECCNSTLRKEKCIAEFVESVKTVISKAKKLRLSRDDFEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDR---RWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPESMAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMEDGRGRYGKECDWWSLGICMYEMLYGTTPFYSERLVDTYGKIMSHQDMLDFPDDEIDWVVSEEAKDLIRQLICSSDVRFGRNGLSDFQLHPFFEGIDWNTIRDSNPPYVPEVSSPEDTSNFDVDVCEDDFTPCLQETQPPRVLAAFTGNHLPFVGFSYTHGSLLSDARSLTDEIR--AIAQRCQGDAELM----EKSVDGFMVELENEK---AELVQKLKEAQTIIAQHVAENPRSEE-DRNYESTIAQLKDEIQILNKRLEDEALAQQQQKPKDEIVAES--EKKLKELKERNKQLVMEKSEIQRELDNINDHLDQVLVEKATVVQQRDDMQAELADVGDSLLTEKDSVKRLQDEAEKAKKQVADFEEKLKEIETEKIALIKKQEEVTIEARKSVETDDHLSEEVVAAKNTIASLQATNE---ERETEIKKLKQRMDEERASHTAQSEQEMKQLEAHY-ERAQKMLQDNVEQMNVENRGLRDEIEKLSQQMAALPRGGLNE-----QQLH-EIFNWVSEEKATREEMENLTRKITGEVESLKNNSPLTTSNYIQNTPSGWGSRRMNNVARKDGLDLQRQLQAEIDAKLKLKAELKNSQEQYLTSAARLDDTEKRMASLMREVAMLKQQKNIENSSDSAFSSTMGRGDLMISMNNDYEMSNSSLMRQEMISRQSTPSYENAILLHDHQVPKRVDDLRYKQKPMKTASGIFSPVSISAMERGHNFERMKIKTPTKCGHCTSILIGLDRQGLFCQSCQYACHVSCAERV-SQSCPVPEEERRPLGIDPTRGVGTAYEGLVKTPRAGGVRKGWQTAYVVVCDFKLYLYDCTVDRQ-NKMQDVKNEIRLVLDMRDPDFTVCGVSEADVIHAQKGDIPKIFRVTTTQILNSSSEYSSSSKFYTLFMAETEEEKRKWVVALSELKTLLRRSKLADRKAFLVKEVFDVTTLP-SIRVAQCCAIIDRSKIVIGFSDHGLYCIEISRQLLIPVGGEKENKQRCVETVEYDEAEQLLMMIVGPAKDRHVRIVPSAALDG-RDLKWIKVNDTKGCHLLAVGTN--NPGGRAGFFA-----------------------VAFKKSVTIFQIDRSEKRHKKWKDLAMPGTPQSIAI--FNGRLYVGFSHSFRSWSLVGVDSSPVGSGDASGAVLQHISLVNMEDTSLQFLNQQTSYEAKLIVNVPGSPDEYLLVFNMIGLYVNEMGRRSRLPEVMFPTQAKYFAYHEPYLCVFSENEVDIFNVTLAE----WVQTINLRSAKPLSGDG-ILSTC---LCNDSPIFVLLQNVLQDQDSIEVPVNLASGSTD---GRKVTRRKFTF----------------------RTIGKDDRSASERRSHIQISTPSDFMHIVHMGP 1558
BLAST of Serine/threonine kinase vs. Ensembl Celegans
Match: let-502 (Rho-associated protein kinase let-502 [Source:UniProtKB/Swiss-Prot;Acc:P92199]) HSP 1 Score: 344.739 bits (883), Expect = 7.598e-98 Identity = 169/415 (40.72%), Postives = 254/415 (61.20%), Query Frame = 2
Query: 119 VTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWD--NLRSYNAPFIPEVSSAEDTSNF-EFDDFNANHEGP-PLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNG 1351
+ +E L+D++ +C++P K+V FI + V+ + +LR++ +DF ++VIGRGAFG+V +VR +YAMK L+K D++K+ D+A F EERD++ A S WI RL YAFQD +LY VM++ GGD++ L++ + + E+ T+FY AE+V ++ +H +GY+HRD+KPDN+L+ GHI LADFG+CVK+ NG AVGTPDYISPE+LR+ +G E DWWS+G+ I+EML GE PFY E TY IMN +T + P E +S +A+D+IK+ + RLG +DD +NH FF +W LR + P IP + S +DT++F E + + ++ G L F G LP IGFT++ ++ +K+L++ GA + NG
Sbjct: 17 INIESLLDTITALVNDCKIPVLMRMKSVDNFISRYERVVESLAALRMKAADFRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFWEERDIMAHA---NSEWIVRLQYAFQDPRHLYMVMEYMPGGDLVNLMTSYE--VSEKWTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHIKLADFGTCVKMNANGVVRCSTAVGTPDYISPEVLRNQGQDAEFGKEVDWWSVGVFIYEMLVGETPFYAEALVSTYTNIMNHKTSLKFPDE-PLISTQAKDIIKKFLSAAPDRLGRNSVDDIRNHKFFVNDEWTFATLREASPPVIPSLKSDDDTTHFEEIETRDRDNAGDFQLPKTFNGNQLPFIGFTYSNEY-----------SPVKNLLKGHGAGSKQNG 414
BLAST of Serine/threonine kinase vs. Ensembl Fly
Match: gek (gene:FBgn0023081 transcript:FBtr0072287) HSP 1 Score: 616.305 bits (1588), Expect = 0.000e+0 Identity = 495/1619 (30.57%), Postives = 799/1619 (49.35%), Query Frame = 2
Query: 122 TLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYD---DVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDFNAN-HEGPPLSSN--FKGCHLPCIGFTFTKDFIFNEMGSE-ESSVRLKSLMENIGAP--ALLNGNHNESNSD-----ALLEEVNQLKITCSQLEKQLNEC-----------RTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIK--SLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQ-VKSLSEEN----VELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKTLC------VDNDGDQKAQGERQDNNG--NESWRLRKCVKADKI---EISNLNLTLQSERRARADLEKK-------LTQQKSEICDISKQLEKYKQDVNEK--------------------------------DNLIANL--------------KSASQNLEPHVP-KEIPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGK---GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVE--FIIKISIENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKD--PHYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGLLKVTDSGYN--KIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEI------SFNEYLILFECAGIFINRNHRQTRP-DLQWPDKPTRFTYRAPYLLCFTEM-AGLFAYEITEHSCNLVQALPLRSSKPLDRSGH-ILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRK-PSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQ---LIDL 4618
+L++L+D+ Y EC + EK V+ F+K K V + LR+ R DFD +++IGRGAFG+V VV+ ++YAMK L+K+++LK+ + ACF+EERDVL + WIT LHYAFQD LY VMD+Y GGD+LTLLSKF D+LPE++ KFYI E++++I+ +H++ Y+HRDIKPDN+LLD GH+ LADFGSC++L +GT + AVGTPDYISPEILR+ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + CF +P++ VS+ ++DL+ +LIC E RLG GI DF +HP+F IDW N+R AP++PEVSS DTSNF+ DD + + P S+N F G HLP IGFTF+ + +SS ++ I +P A+L N++E+ D AL +++ LK ++L KQ NE + QR + Y ++ +L Q Q +R+KE+++D ++ N L E L+K +L++ E+ + K + + +L ++ E LSI S +I+ + +F E + ++ ++ LE +R + S L N+ + + +E +K ++ I + E L+L +++E K S EE+ R L+S LKS+ +K L E+ ELR + I+ + ++ + D++ + + L T++ E+E LK + VDN + + ++ D N L++ ++A + E+S L S ++ D +K+ ++++E+ D+ K +Y + K DN N K A +N + H KE + ++ E + ++ S K N H F TF+ P KC++CTS M+G QGV C+ C F+CH C V C K G + GIGT YE ++KVPK G I+RGW RQF+ +CD KLF +D+ +P +S + +V+D++ EF V V +V+HA KKDV F IK ++ + L +L ++ K + + E +K++ P+ IF L+N +S+ R L + II + +L GTE+GL + Y +IGE K + + ++++ Q++ ++ KQR L+LL L+ A D E I V K+C + G P ++ + +K P+N + VY +N TRH+K + LQI +L++ Y L + + L+H + + ++ + +++ ++EI +F EYL++F+ I+++ R++R ++ +P PT T+ +LL F++ +F + E VQ++ L+ S PL+ G+ +L++ N+ + L +H + L ++ N++ PS ++ + N I + + ++ IS P NF H+SHMGP Q L+DL
Sbjct: 50 SLDYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDR---QWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNFDVDDNDVRLTDSIPPSANPAFSGFHLPFIGFTFSLTSSSTLDSKKNQSSGFGDDTLDTISSPQLAILPSNNSETPVDSVQLKALNDQLAALKQEKAELSKQHNEVFERLKTQDSELQDAISQRNIAMMEYSEVTEKLSELRNQKQKLSRQVRDKEEELDGAMQKNDSLRNE-----------LRKSDKTRRELELHIEDAVIEAAKEKKLREHAEDCCRQLQMELRKGSSSVETTMPLSISSEMSSYEIERLELQFSEKLSHQQTRHNMELEALREQFSELENANLALTKELQQTQERLKYTQMESITDSAETLLELKKQHDLE--KSSWFEEKQR-LSSEVNLKSKSLKELQAEDDEIFKELRMKREAITLWERQMAEIIQWVSDEKDARGYLQA-LATKMTEELEYLKHVGTFNNNGVDNKNWRNRRSQKLDKMELLNLQSALQREIQAKNMISDELSQTRSDLISTQKEVRDYKKRYDSILHDFQKKETELRDLQKGGLEYSESFLNKSTHHGLSSAFFRDMSKNSEIIDSAESFGNESGDNFTPNFFQSGNSGMLFNYEPKYAGKNNKDHSSMKEASVSDLSREESDQLVKESQKKVPGNTAIHQFLVRTFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHTICCQKVPT-TCPVPMDQTKRPLGIDPTRGIGTAYEGYVKVPKSGVIKRGWIRQFVVVCDFKLFLYDISPDRCA--LPSVSVS--QVLDMRDPEFSVGSVRESDVIHAAKKDVPCIFKIKTALIDGGLSLNTLMLADNESEKSKWVIALGELHRILKRNSLPN-TAIFKVNEILDNT-LSL-IRNALCSVIIYPNQILLGTEDGLFYINLDQYEIARIGESKKILQLWYIEEE--QILVILCGKQRNLRLLPIRALE-ASDVEWIKVVESKNCISACTGIIRRFP---------NIVYSFIIALKRPNN----------HTQIVVYEINRTRTRHQKTCEFTIGYMAQHLQILSD-MRLVVAHQSGFTAYFLRGEATAMSLVHPENQLCA----FLNYSGVDAVRVIEILCPSGGNFGEYLLVFQTLAIYVDLQGRKSRDREIMYPAFPTYITFCDGHLLVFSDTHLDIFNTQTAE----WVQSIGLKQSLPLNNLGNVVLSSVNDTPLIVYLSNIH--------------------TKGLLQYRDGNRKGLPSIKRRFSIREINKTIKSD-------------------RRSKMISAPTNFNHISHMGPGDGIQNQRLLDL 1572
BLAST of Serine/threonine kinase vs. Ensembl Fly
Match: Rok (gene:FBgn0026181 transcript:FBtr0074286) HSP 1 Score: 368.237 bits (944), Expect = 2.172e-104 Identity = 212/567 (37.39%), Postives = 331/567 (58.38%), Query Frame = 2
Query: 110 PDSV-TLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDW--DNLRSYNAPFIPEVSSAEDTSNFE-FDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSL-MENIGAPALLNGNHNE-----SNSDAL--LEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPV-YQQLVTDKEK-LLTQCQNYDYSLREKEQKMD-------DLIETNRLLNKE-----RDELTSDRLQILQKK-QDIEEDLKVMTENFNQLKSTNKAIN 1729
P S+ ++ L+D++ +C + KN+ Q+ K +I LR+ DF I++IG GAFG+V +VR K ++YAMK L K++++K+ D+A F EER ++ A S WI +LH+AFQD YLY VMDF GGD+++L+ ++ +PE+ FY EVV+++D +H +G++HRD+KPDN+LLDS GH+ LADFG+C+++ NG ++ AVGTPDYISPE+L+S YG ECDWWS+GI ++EML+GE PFY + TY +IM+ + P E ++S++A+ LI+ + + RLG GI+D K HPFFR W DN+R P +PE+SS +DT NFE + E P+ F G HLP IGFT+T D+ + S+ K + N GA + +G+ + SNS+ L LE + + + S+ +Q + ++ I Q++ ++ EK L + NY ++++ EQ+++ L+ET R L E RD +D++ L+K+ ++E+ K TEN +LK N ++
Sbjct: 32 PTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHA---NSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD--IPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEV-EISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVFPVPKGFDGNHLPFIGFTYTGDYQL--LSSDTVDAESKEANVANSGAASNNHGHGHNHRHRPSNSNELKRLEALLERERGRSEALEQQDAGLRQQIELITKREAELQRIASEYEKDLALRQHNYKVAMQKVEQEIELRKKTEALLVETQRNLENEQKTRARDLNINDKVVSLEKQLLEMEQSYKTETENTQKLKKHNAELD 590
BLAST of Serine/threonine kinase vs. Ensembl Fly
Match: Rok (gene:FBgn0026181 transcript:FBtr0340152) HSP 1 Score: 367.851 bits (943), Expect = 2.297e-104 Identity = 212/567 (37.39%), Postives = 331/567 (58.38%), Query Frame = 2
Query: 110 PDSV-TLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDW--DNLRSYNAPFIPEVSSAEDTSNFE-FDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSL-MENIGAPALLNGNHNE-----SNSDAL--LEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPV-YQQLVTDKEK-LLTQCQNYDYSLREKEQKMD-------DLIETNRLLNKE-----RDELTSDRLQILQKK-QDIEEDLKVMTENFNQLKSTNKAIN 1729
P S+ ++ L+D++ +C + KN+ Q+ K +I LR+ DF I++IG GAFG+V +VR K ++YAMK L K++++K+ D+A F EER ++ A S WI +LH+AFQD YLY VMDF GGD+++L+ ++ +PE+ FY EVV+++D +H +G++HRD+KPDN+LLDS GH+ LADFG+C+++ NG ++ AVGTPDYISPE+L+S YG ECDWWS+GI ++EML+GE PFY + TY +IM+ + P E ++S++A+ LI+ + + RLG GI+D K HPFFR W DN+R P +PE+SS +DT NFE + E P+ F G HLP IGFT+T D+ + S+ K + N GA + +G+ + SNS+ L LE + + + S+ +Q + ++ I Q++ ++ EK L + NY ++++ EQ+++ L+ET R L E RD +D++ L+K+ ++E+ K TEN +LK N ++
Sbjct: 32 PTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHA---NSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD--IPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEV-EISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVFPVPKGFDGNHLPFIGFTYTGDYQL--LSSDTVDAESKEANVANSGAASNNHGHGHNHRHRPSNSNELKRLEALLERERGRSEALEQQDAGLRQQIELITKREAELQRIASEYEKDLALRQHNYKVAMQKVEQEIELRKKTEALLVETQRNLENEQKTRARDLNINDKVVSLEKQLLEMEQSYKTETENTQKLKKHNAELD 590
BLAST of Serine/threonine kinase vs. Ensembl Fly
Match: Rok (gene:FBgn0026181 transcript:FBtr0340153) HSP 1 Score: 367.851 bits (943), Expect = 2.630e-104 Identity = 212/567 (37.39%), Postives = 331/567 (58.38%), Query Frame = 2
Query: 110 PDSV-TLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDW--DNLRSYNAPFIPEVSSAEDTSNFE-FDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSL-MENIGAPALLNGNHNE-----SNSDAL--LEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPV-YQQLVTDKEK-LLTQCQNYDYSLREKEQKMD-------DLIETNRLLNKE-----RDELTSDRLQILQKK-QDIEEDLKVMTENFNQLKSTNKAIN 1729
P S+ ++ L+D++ +C + KN+ Q+ K +I LR+ DF I++IG GAFG+V +VR K ++YAMK L K++++K+ D+A F EER ++ A S WI +LH+AFQD YLY VMDF GGD+++L+ ++ +PE+ FY EVV+++D +H +G++HRD+KPDN+LLDS GH+ LADFG+C+++ NG ++ AVGTPDYISPE+L+S YG ECDWWS+GI ++EML+GE PFY + TY +IM+ + P E ++S++A+ LI+ + + RLG GI+D K HPFFR W DN+R P +PE+SS +DT NFE + E P+ F G HLP IGFT+T D+ + S+ K + N GA + +G+ + SNS+ L LE + + + S+ +Q + ++ I Q++ ++ EK L + NY ++++ EQ+++ L+ET R L E RD +D++ L+K+ ++E+ K TEN +LK N ++
Sbjct: 23 PTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHA---NSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD--IPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEV-EISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVFPVPKGFDGNHLPFIGFTYTGDYQL--LSSDTVDAESKEANVANSGAASNNHGHGHNHRHRPSNSNELKRLEALLERERGRSEALEQQDAGLRQQIELITKREAELQRIASEYEKDLALRQHNYKVAMQKVEQEIELRKKTEALLVETQRNLENEQKTRARDLNINDKVVSLEKQLLEMEQSYKTETENTQKLKKHNAELD 581
BLAST of Serine/threonine kinase vs. Ensembl Fly
Match: Rok (gene:FBgn0026181 transcript:FBtr0340151) HSP 1 Score: 367.081 bits (941), Expect = 5.729e-104 Identity = 212/567 (37.39%), Postives = 331/567 (58.38%), Query Frame = 2
Query: 110 PDSV-TLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDW--DNLRSYNAPFIPEVSSAEDTSNFE-FDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSL-MENIGAPALLNGNHNE-----SNSDAL--LEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPV-YQQLVTDKEK-LLTQCQNYDYSLREKEQKMD-------DLIETNRLLNKE-----RDELTSDRLQILQKK-QDIEEDLKVMTENFNQLKSTNKAIN 1729
P S+ ++ L+D++ +C + KN+ Q+ K +I LR+ DF I++IG GAFG+V +VR K ++YAMK L K++++K+ D+A F EER ++ A S WI +LH+AFQD YLY VMDF GGD+++L+ ++ +PE+ FY EVV+++D +H +G++HRD+KPDN+LLDS GH+ LADFG+C+++ NG ++ AVGTPDYISPE+L+S YG ECDWWS+GI ++EML+GE PFY + TY +IM+ + P E ++S++A+ LI+ + + RLG GI+D K HPFFR W DN+R P +PE+SS +DT NFE + E P+ F G HLP IGFT+T D+ + S+ K + N GA + +G+ + SNS+ L LE + + + S+ +Q + ++ I Q++ ++ EK L + NY ++++ EQ+++ L+ET R L E RD +D++ L+K+ ++E+ K TEN +LK N ++
Sbjct: 32 PTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHA---NSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD--IPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEV-EISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVFPVPKGFDGNHLPFIGFTYTGDYQL--LSSDTVDAESKEANVANSGAASNNHGHGHNHRHRPSNSNELKRLEALLERERGRSEALEQQDAGLRQQIELITKREAELQRIASEYEKDLALRQHNYKVAMQKVEQEIELRKKTEALLVETQRNLENEQKTRARDLNINDKVVSLEKQLLEMEQSYKTETENTQKLKKHNAELD 590
BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Match: cdc42bpaa (CDC42 binding protein kinase alpha (DMPK-like) a [Source:ZFIN;Acc:ZDB-GENE-120727-12]) HSP 1 Score: 478.404 bits (1230), Expect = 6.122e-140 Identity = 321/915 (35.08%), Postives = 490/915 (53.55%), Query Frame = 2
Query: 122 TLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSV---------------------------RL--------KSLMENIGAPALLNGNHNESNSDALLE-EVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDL-------IETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEK---QRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQS----------DQTIFNIKEEIKSLKEIFTNKEKNLK----------LSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDK------------EIVKTSENSE--------LLTELDREVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIANLKSASQNL 2596
++E L+D L C Y EC + EKNVA+F++ K K++ +R+ + DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL S WIT LHYAFQD+ +LY VMD+Y GGD+LTLLSKF DRLPE++ +FY+AE+V++ID VH+L Y+HRDIKPDN+L+D GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ P + DVS+ A+DLI++LIC +E RLG GI+DFK HPFF IDW N+R+ +AP+IPEVSS DTSNF+ DD N PP + F G HLP +GFT+T + ++ G S RL + L E+ A L + ++ + E E+ LK L+KQ+ + T V++ + + +D E Q ++ + L+ +Q+ DDL + ++ KE E S R +Q+ ++ E + + +L + E D L +++ L+ K + K + +Q + + Q EK +R E+ QL E D + +K + S T S EQ+ ++ + KEE+ +++ N+ K+LK LS EI LK + + + + +L+ + LSEEN +L S L ++S N + +++ + D+ EI++ + + L T++ E+E LK + G R + W++R+ K D L L +E +A+ ++ +L + K+ +LE+ ++ + I LK + NL
Sbjct: 27 SVESLLDVLICIYDECTNSPLRREKNVAEFLEWAKPFTSKVKQMRLHKEDFEILKVIGRGAFGEVAVVKVKSSDKVFAMKILNKWEMLKRAETACFREERDVLVNG---DSQWITTLHYAFQDDNFLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVLAIDSVHQLHYVHRDIKPDNILIDVNGHIRLADFGSCLKLTEDGTVQSSVAVGTPDYISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQMTDVSENAKDLIRRLICCREHRLGQNGIEDFKQHPFFSGIDWQNIRNCDAPYIPEVSSPSDTSNFDVDDDCLKNTETMPPPSHTAFSGHHLPFVGFTYTSNCTLSDRGCLRESAAPAQMDVCVQRGLEDSLATEAYERRIRRLEQEKLELGRKLQESTKAVQALQYSSSDGPVSSNREFEIRGLKEEIEMLKKQIAD--TGQVEQQLEQAISAR--SDMEDSSKQIRSLEKQLKSTKQERDDLQKRLQESSDKQKVQGKELKEADSQRKMAMQEFAEVSEKVTELRSLKQRLTRQLRDKEEELDSLNQKVEALRLDVRKAERAKKEMEVQAEEWSAEAQKEKKLRERSEQFSRQLEEELDSIKQK-HVGRSPSTGSSEQNQELSKLRADLEKKTVHFKEELSRIEQQHANELKSLKKELKESEGQQLSLKKEIMMLKDKLDKSRRESHSERDELEFERVLLSEENKKLSSELDKLSCSNKQLEEKIRVLADEKESVAHWEAQITEIIQWVSDEKDARGYLQALATKMTEELEGLKNASL---------GARATDM---PWKVRRLAKLDMSARLELQSALDAEIKAKQTIQDELNKVKASHMATECKLEESEKQNQDLQAEIQRLKQETDNL 921 HSP 2 Score: 234.572 bits (597), Expect = 2.171e-61 Identity = 192/650 (29.54%), Postives = 301/650 (46.31%), Query Frame = 2
Query: 2702 HVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGKGA---NLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIE----NSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDP-HYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRP-DLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYN--KQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
H F TFN P KC+ CTS M+G QG C+ C+FSCH C ++ C KG + + GIGT YE +KVPKP G+++GW+R +CD KLF +D+ EG P + N +VID++ EF V V +V+HA +KD+ I +++ +S+ I +L +S + + +++E +KK R ++ K + + Q SAAIID + G EEGL + VT K+G+ K V+ IE + + QL+AVI + ++L LD D E + K C T + G + G+ L +K P + V VY LN RH KLR+IL SV + + GE+L +G YSL G L D +I Q +S+ VEIS E L+ F GI+++ R++R +L WP PT Y APYL ++E A + +++ ++ +Q +PL+ PL+ G + ++ + LIY +A +++ + +T D + S +KR+ S+ ++E + + RD P ++ N+ IS P NF H+ HMGP Q++
Sbjct: 1034 HQFVVKTFNTPTKCNQCTSLMVGIIRQGCTCEVCNFSCHVTC-ADKAPAVCPIPPDQTKGPLGIDPQKGIGTAYEGHVKVPKPLGVKKGWQRAIAVVCDFKLFLYDLPEGKAA--QPGVVVN--QVIDMRDEEFSVSPVLASDVIHANRKDIPCIFRVTASQLCASSNKKCSILILADSDQERTKWVGLLKELHRLLKKSKLKERFVYVPKEAYDCALPLIKTTQ--SAAIIDHERIALGNEEGLYVIHVTKDEIIKVGDNKKVHQIELIPSE--QLIAVISGRNGHVRLYPMTALDD-RDVESYKIAETKGCQTLLSGT--IRHGS---------LTCLFVAMKKP-------------DKVIVYELNKSKARHRKLREILVPGSVQWMGL--QGEKLCVGFQSGFLRYSLQGDGG----TSSLLHPDDHTLGFIEQLGLDSLCAVEISSKELLLCFSSIGIYVDYQGRRSRQQELMWPATPTACRYNAPYLSVYSENA-VDVFDV--NTMEWIQTIPLKKVHPLNSDGSLNLLG---LETVRLIYFKNKTAEGDELVVPETSDNSRKQMVRST---ASKRRFSFRIPEEERVLQRREML----------------RD-PEIR-NKLISNPTNFNHVVHMGPGDGIQIL 1616
BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Match: cdc42bpb (CDC42 binding protein kinase beta (DMPK-like) [Source:ZFIN;Acc:ZDB-GENE-030131-3647]) HSP 1 Score: 471.47 bits (1212), Expect = 2.218e-137 Identity = 319/879 (36.29%), Postives = 494/879 (56.20%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD--FNANHEGPPLS-SNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLE-EVNQLKITCSQLEK-QLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREKE-QKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEV---MLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFT---------NKEKNLKLSH--------DNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELD----REVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIANL 2575
MS K+ LK+ +++ LL+ S+++E L+D L C Y EC K EK+V F++ +K ++ +R+ R DF+ ++VIGRGAFG+V+VV+ K +YAMK L+K+++LK+ + ACF+EER+VL WIT LHYAFQD+ YLY VMD+Y GGD+LTLLSKF DRLPE++ KFY+AE+V++I +H+ Y+HRDIKPDN+LLD GHI LADFGSC+K+ +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN E FQ P+ DVS++A+DLI++LIC +E RLG GI++F+ H FF IDW+N+R+ AP+IP+VSS DTSNF+ DD PP+S + F G HLP +GFT+T + F++ GS M + AL +G E D ++ E + +I C + EK +LN S Q + S L + R+KE +K+++ E +RL K D SDRL+ +EE + + ++F + KA++++ L+ E + + KQ ++ + +K + + + ++ Q F EV M +LRS+ ++ ++R K + +++ D +I++ K+ KE+ + +KE+ L+ H ++E+E LK+ ++ L + TQ +E +L+S E+ K + + + ++ +E T+E L EL +++ L K L + +KA+ ERQ L++ + ++ +S N L +E KLT Q ++ D ++L K+ V + IA +
Sbjct: 1 MSAKVRLKK-----LEQLLLDGHQKNDKSLSVETLLDILICLYNECSNSPLKREKHVTDFLEWVKPFTTTVKEMRLHRDDFEMLKVIGRGAFGEVAVVKMKHTERVYAMKILNKWEMLKRAETACFREERNVLVNG---DCQWITTLHYAFQDDNYLYLVMDYYVGGDLLTLLSKFEDRLPEDMAKFYVAEMVLAIHSIHQQRYVHRDIKPDNVLLDMNGHIRLADFGSCLKMMQDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHITDVSEDAKDLIQRLICSRERRLGQHGIEEFRKHAFFSGIDWENIRNMEAPYIPDVSSPSDTSNFDVDDDVLKNPDIAPPVSHTGFTGQHLPFVGFTYTTESCFSDGGS----------MRGV---ALSDGGTGEDLQDGGMQVEAFEKRIRCLEQEKLELNRKLQESTQAVQS-------------LHGSGRGAGTLGRDKEIKKLNE--EIDRLKKKLAD---SDRLE-----HQLEEAV-TLRQDFESSSTKLKALDKQVKALKLEKEDIHKQLVESLDRLKSQTKELKDAHQQRKLAMQEFSEVNERMAELRSQKQRLSRQLRDKEEEMEVVMQKIDAMRQDIRKTEKARKELESQLEDARAEASKERKLR-EHSEVYSKQLESELETLKVKQGAGRASGLGAETQ---------QELTKLKS---ELDKKGLYYE---EELVRREASHTTEMKNLRKELQDSEGQQLSLHKELLALKEKLEKAKRERQIEMEEAINALKEQYERERNLMSEDNRKLTAETDRLCSFVDKLTAQNRQLEDELQELASKKESVAHWEAQIAEI 818 HSP 2 Score: 201.83 bits (512), Expect = 1.942e-51 Identity = 172/659 (26.10%), Postives = 303/659 (45.98%), Query Frame = 2
Query: 2681 TVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGK---GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKI---SIENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDP-HYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRP-DLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSS--SNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQ-LIDL 4618
T H S TF+ P +C +CTS M+GQ QG C+ CSF CH C N C K G +++ GIGT Y+ F+++PKP G+++GW+R + +CD KLF ++V EG + + S +V+DL+ EF V V +V+HA KDV I ++ ++++S +P+ +L ES K + ++E +S + K+ R++ ++ ++ + LSAAI+D+ ++ GTE+GL +++T + + K V IE + ++ ++VA++ + R + L L+GA + + + C +G + PG P+ + A K V Y + H KL ++ V L I E++ +G A+ ++ SP + D + ++ Q +++ +E+ NE L+ F G++++ R++R +L WP P + + L +++ G+ +++ H+ VQ + LR +PL+ G + + I+ LIY S++ ++I +T D + T S KFL K P + RD P ++S + IS P NF H++HMGP Q L+DL
Sbjct: 1015 TAPKPKAHQLSIKTFSSPTQCTHCTSLMVGQMRQGYACEVCSFICHVSCKDNA-PQLCPIPPEQTKRPLGIDVQRGIGTAYKGFVRIPKPTGVKKGWQRAYAVVCDCKLFLYEVPEGKSTQPVVMAS----QVLDLRDEEFSVSSVLASDVIHANHKDVPCIFRVTSSALKSSIRPVPLLILAESEAEKRKWVGILEGLQSILAKNRLKNRVVHVLHEAYDSSLPAI--KTTLSAAIVDRERIVLGTEDGLFVVEITRDVIVRAADCKKVCQIELIPKE--KMVALLSGRNRHVHLYPWAALEGAEGGFDAKLTDTRGCQAMTIGN--LRPGG-------------------PA-----CLFAGVKRQVFCYEITRAKPHHRKLWEVQAPGVVQWLGII--RERICVGYPSGFALLAMQGESSP----VSLVSPGDPSLAFLAQQPLDALHAMEVGSNELLLCFSQLGVYVDATGRRSRTQELMWPSTPLACSSNSNCLTVYSDY-GVDVFDV--HTMEWVQTISLRKIRPLNVEGSLNLLS---IEQPHLIYFSNNSSDGCDLAIPETSDNSKKLMVRTRSKRKFLFK--------------------VPEEERLQQRREMLRD-PEMRS-KLISHPTNFNHVAHMGPGDGMQVLMDL 1604
BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Match: cdc42bpab (CDC42 binding protein kinase alpha (DMPK-like) b [Source:ZFIN;Acc:ZDB-GENE-080219-17]) HSP 1 Score: 469.159 bits (1206), Expect = 1.222e-136 Identity = 233/470 (49.57%), Postives = 315/470 (67.02%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEK 1429
MS+++ LK+ L K + S ++E L+D L C Y EC + EKNV +F+ K K++ +R+ + DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL WIT LHYAFQDE LY VMD+Y GGD+LTLLSKF DRLPE++ KFY+AE+V++ID VH+L Y+HRDIKPDN+L+D GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ P + DVS++A+DL+++LIC +E RLG GI+DFK HPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N PP + F G HLP +GFT+T ++ G L E++G PA ++ + S ++L E + +I + EK
Sbjct: 1 MSVEVRLKK----LEKLIMDGPSQSSGQCFSMETLLDILVCLYDECSSSPIRREKNVLEFLDWAKPFTSKVKQMRLHKEDFEILKVIGRGAFGEVAVVKVKNTDKVFAMKILNKWEMLKRAETACFREERDVLVNG---DCQWITTLHYAFQDENNLYLVMDYYVGGDLLTLLSKFEDRLPEDMAKFYLAEMVLAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPLQVTDVSEDAKDLVRRLICSREHRLGQNGIEDFKQHPFFTGIDWDNIRTCEAPYIPEVSSPTDTSNFDVDDDCLKNCETLPPPSHTAFSGHHLPFVGFTYTSKCTLSDRG---------CLRESVG-PAQVDAHVQRSLEESLASEAYERRIRRLEQEK 453 HSP 2 Score: 226.483 bits (576), Expect = 5.666e-59 Identity = 224/932 (24.03%), Postives = 407/932 (43.67%), Query Frame = 2
Query: 2003 KEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDK------------EIVKTSENSE--------LLTELDREVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARADL--------------EKKLTQQKSEICDISKQLEKYKQDVNE------------KDNLIANLKSASQNLEP-----HVPKEIPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLND-KCYTRKSAGK-GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIENSSTMLP----IYVLFESVDNKEDCIKVIEEARSYIKKDP-HYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYN-KQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
KEI K+K K ++++E+ + V E + + L + K LS E +L +++S+ + + ++ + DK EI++ + + L T++ E+E L+ + G + W++R+ K D L L +E RA+ + E KL + +S ++ ++E+ +++ E +++ +A L + + L+ H + + + P S + GSL + H FS +FN P KC+ CTS M+G QG C+ CSFSCH C + ++ GK G + + GIGT YE ++VPKP G+++GW+R + +CD KLF +++ EG G Q P + N +VID++ EF V +V+HA +KD+ I +++ S I +L ++ + + + E ++K+ R ++ K ++ + Q +AAIID + G EEGL + VT ++G+ K V+ +E + + ++AVI + R + L+ LDG + + V + K+C V G ++ N T C A K + + +N +RH L I +V + + +QL +G YSL+ P L D +I N +++ VEIS E L+ F ++++ + R++R +L WP PT Y APYL ++E A + +++ +S +Q +PL+ +PL+ G + ++ + LIY +A +++ + + D + S+ NKR+ S+ +E+ + +P + N+ IS P NF H++HMGP Q++
Sbjct: 733 KEILVLKDKLEKTRRESQVEREEF-VCEYKQKYEREKAHLTDENKKLSAEVEKLNGQFEQLSSSHRQLEEEMRELADKKESVAHWEAQITEIIQWVSDEKDARGYLQALATKMTEELEGLRNTSLGARGT------------DMPWKMRRFAKLDMSARLELQSALDTEIRAKQSIQDELNKVKATNIATECKLQESESRNQELLGEIERLRKETEELRLRRGVKHQDSQNSFLAFLNAPTSALDQFDLIDHTSRSLQT-PTGRSGY-----GSLGHSSPKPKAHQFSVKSFNVPTKCNQCTSLMVGLIRQGCTCEACSFSCHVTCADKAPSVCPVAPDQTRGKLGIDTQRGIGTAYEGHLRVPKPTGVKKGWQRVWAVVCDFKLFLYELGEGK-GAQ-PGVVVN--QVIDMRDEEFSASSVLESDVIHANRKDIPCIFRVTASQLSASSSQKTCILILADNEQERTKWVCALNELHRILRKNKLKERFVYVPKEAYDSTLPLIKTTQ--TAAIIDHERVALGNEEGLFVIHVTKDEIIRVGDVKKVHHVELMPTE--HILAVISGRNRQVCLVSMAGLDG-REVDKNKVADTKNCQLLVSG----------------VVRNVT------------CFCLAIKRQISCFEINKSKSRHSHLVDIQAPGTVQWMAL--FNQQLCVGYPSGFMRYSLYGETPP----ASLLHPDDPTLAFIKTDNLDALCAVEISNKELLLCFSKIAVYVDTHGRRSRQQELMWPAAPTACCYNAPYLSVYSENA-VDVFDV--NSTEWIQTIPLKKVRPLNMDGSLNLLG---LETVRLIYFRNKTAEGDELVVPEVCDNSRKQMVRSMS---NKRRFSFRIPEEERLQQRREMLKDPE-----------------RRNKLISNPTNFNHVAHMGPGDGMQIL 1576
BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Match: CU929346.1 (pep chromosome:GRCz11:10:360237:373575:-1 gene:ENSDARG00000074914.4 transcript:ENSDART00000114487.4 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:CU929346.1) HSP 1 Score: 368.237 bits (944), Expect = 1.568e-113 Identity = 183/388 (47.16%), Postives = 260/388 (67.01%), Query Frame = 2
Query: 119 VTLEFLIDSLFCTYYE-CRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDFNANHEGP---PLSSNFK----GCHLPCIGFTFTK 1258
V L+ L+D L Y E C P + EK+V +F++ + V +++ RI R DF ++VIGRG F +V++ R + ++YA+K ++K+D+LK+ + AC+QEER+VL +K WIT LHYAFQD+ YLY VM +Y GGD+LTLLSKFND LPEE+ +FY+AE+VM+ID VH LGY+HRDIKPDN+LL + GH L DFGSC++L +G + AVGTPDY+SPE+LR+ E G YG +CDWW+LG+ +EML G PFY E SETY +I++F+ ++P VS+ A + L+CK+ RLG+ G DF++HPFF +DW +L + P+ P+VS+A DTSNF+ D + P LS + G HL +G+++T
Sbjct: 28 VGLQTLLDLLVGVYQEFCSSPLRR-EKHVQRFLQWAEPLVRQVKKTRISREDFHILKVIGRGTFSEVALARMRNTQQVYAVKIMNKWDMLKRGEMACYQEEREVL---LKGDRRWITELHYAFQDDDYLYLVMHYYVGGDLLTLLSKFNDGLPEEMAQFYLAEMVMAIDSVHLLGYVHRDIKPDNILLTADGHARLGDFGSCLRLEDDGLVHSAVAVGTPDYLSPELLRAVEAGGGYGSDCDWWALGVCAYEMLLGTTPFYAESISETYAKIIHFKLILELPLVGVQVSEPA----RALVCKRSERLGSGGSADFRSHPFFSGLDWSSLHLHPPPYRPDVSNATDTSNFDVLDDCLSETVPQPETLSDVMERAPVGVHLAFVGYSYTA 407
BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Match: rock1 (Rho-associated, coiled-coil containing protein kinase 1 [Source:ZFIN;Acc:ZDB-GENE-100712-2]) HSP 1 Score: 378.252 bits (970), Expect = 9.345e-108 Identity = 187/445 (42.02%), Postives = 280/445 (62.92%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFR--EIDWDNLRSYNAPFIPEVSSAEDTSNF-EFDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRL----------KSLMENI 1327
MSI +L R E I L + KS V + L+DSL Y+ P + K++ F+K K T+ KI LR++ D++ ++VIGRGAFG+V +VR K ++YAMK L K++++K+ D+A F EERD++ A S W+ +L YAFQD+ YLY VM++ GGD++ L+S ++ +PE+ +FY AEVV+++D +H +G++HRD+KPDN+LLD GH+ LADFG+C+K+ +G + AVGTPDYISPE+L+S G G YG ECDWWS+G+ ++EML G+ PFY + TY +IMN + P E D+S +A+ LI + +E RLG G+D+ K H FF+ + W+N+R AP +PE+S DTSNF + ++ E P+ F G LP +GFT+ + +F S+ES+++ KSL+EN+
Sbjct: 3 MSIGESLTARFEK-IDAMLKDPKSEV----NTDCLLDSLDALVYDLDFPALRKNKSIDDFLKRYKDTISKIRELRMKAEDYEVVKVIGRGAFGEVQLVRHKATRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA---NSNWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDGIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKDGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNALTFP-EDSDISKDAKSLICAFLTDREVRLGRNGVDEIKRHGFFKNDQWTWENIRETAAPVVPELSCDTDTSNFDDIEEDRGEEETFPIPKAFVGNQLPFVGFTYYSNNLF----SQESTIKTSDKRSSTKEDKSLLENL 432
BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Match: CDC42BPA (CDC42 binding protein kinase alpha [Source:NCBI gene;Acc:100497067]) HSP 1 Score: 677.167 bits (1746), Expect = 0.000e+0 Identity = 527/1648 (31.98%), Postives = 805/1648 (48.85%), Query Frame = 2
Query: 116 SVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPAL-LNGNHNESNSDALLEE-----VNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVT--------------DKEKLLTQCQ----------------NYDYSLR-----------EKEQKMDDLIETNRLL---NKERDELTSDRLQILQKKQDIEE---DLKVMTENF-NQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKE-KNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKE-IVKTSENSELLTELDREVELLKTLCVDND---------GDQK----------------------AQG----------ERQDNNGNES---------WRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEIC--------------DISKQLEKYKQDVNE------------KDNLIANLKSASQNLEPHVPKEIPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKC--YTRKSAGK-GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDP-HYRMIFTEKSCLNN-LDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRF--TYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
S+++E L+DSL C Y EC + +K++ +I+ K K++ +R+ + DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL S WIT LHYAFQD+ LY VMD+Y GGD+LTLLSKF DRLPE++++FY+AE+V++ID VH+L Y+HRDIKPDN+LLD GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ PT+ DVS+ A+DLI++LIC +E RLG GI+DFKNHPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N PP + F G HLP +GFT+T + + S+ SS+R S G P+ L+ N S D+L E + +L+ +L ++L E T +VQ H VT DK K L Q + +R EKE DL+E+N + KE E S R Q LQ+ ++ E +L+ + F QL+ + + LE L++ +KE + +++ D ++ +++ E+ QL SE + + K + ++NS Q Q I +K +++ K +F +E + H EI+ LK + + +S+ L N ++ L + E +S +E F +K D+E ++ EN +L +ELD+ + + L V+N D+K A+G E D N S W++R+ K D L L +E RA+ ++++L + K+ I D++ ++EK K + +E +++ +A L + + L+ H + SNP + + H F TFN P KC+ CTS M+G QG C+ C FSCH C ++ C T ++ G G + + GIGT YE +KVPKP G+++GW+R +CD KLF +++ EG + +S +VID++ EF V V +V+HA +KD+ I +++ + SS I +L +S K + V+ E +KK+ R ++ K ++ L + N + SAAI+D + G EEGL + VT ++G+ K V+ +E + + QL+AVI + R ++L LDG +VE K C V G+ V G + +C + K V Y LN TRH+K+++I +V + I E+L +G Y L GSP + L D +I Q +++ VEIS EYL+ F G++++ R++R +L WP P Y PY + + +PL+ G + ++ I LIY A +++ + +T D +S + NKR+ S+ P + RD P ++ N+ IS P NF H++HMGP Q++
Sbjct: 23 SLSVESLLDSLLCLYDECSASPLRRDKHINDYIQWAKPFALKVKQMRLHKEDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---DSQWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMSRFYLAEMVLAIDSVHQLHYVHRDIKPDNILLDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQLADVSENAKDLIRRLICSREHRLGQNGIEDFKNHPFFVGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNCETMPPPTHTGFSGHHLPFVGFTYTSNCVL----SDRSSLRDAS-----GTPSTDLDANVQRSLEDSLATEAYERRIRRLEQEKVELTRKLQES-TQAVQ-ALQHSAVDGPVTASKDLEIKSLKEELDKLKTLGANQLTQQLDKSGLARPDFEEFSRQIRVFEKQVKVLKQEKEDLNKDLVESNEKMKTQTKELKEAQSQRKQALQEMAELNERLTELRSQKQKFVRQLRDKEEEMEAVAQKLEGLRQDLRRVERAKKELEAQMDSAASEASKDRKL-REKSEQYTKQLESELEGLKLKQVGRPLGVSNSEHQ--QEIAKLKTDLEK-KSVFYEEEFAKREALHAGEIKNLKKELRDAESQQLNLNKEILVLKDKLDKTRRESQSEREE-------FEAEMKQKFDRERLLLMEENKKLSSELDKLSAMFEKLSVNNRHLEEEMRDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELDTLRNSSLGAKPTDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKAKAAIIATECKLQESDKKNQDLTTEIEKLKWETDELRSEKGVKHQESQNSFLAFLNAPTSVLD-HFERSPSSNPASKGRRVRGCLALCAPPFLPPKAHQFVVKTFNAPTKCNQCTSLMVGLIRQGCTCEVCGFSCHVTC-ADKAPAVCPIPTDQTKGPLGIDPQKGIGTAYEGHVKVPKPAGVKKGWQRAMAVVCDFKLFLYEIAEGKSSQTSCVVS----QVIDMRDEEFAVSSVLASDVIHANRKDIPCIFRVTASQLSASSNKCSILLLADSESEKGKWVGVLNELHRILKKNKLKDRSVYVPKEAYDSTLPLIKNTQ---SAAILDHERIALGNEEGLFVVHVTKDEIIRVGDNKKVHQVELIPSE--QLIAVISGRNRHVRLYPMISLDGRETEFYKLVET-KGCQGIVSGQ--VRHGA------------------------LTCLCVSMKRQVLCYELNQSKTRHKKIKEIQVPGNVQWMAI--FNERLCVGYQSGFMRYPLHADGSP----YSLLHSDDHTLSFITQQATDAICAVEISNKEYLLCFSSVGVYVDCQGRRSRQQELMWPAGPLSCCKGYIIPYPHIYHHV------------------------RPLNSEGSLNILG---LETIRLIYFKNKMAEGDELVVPETSD---NSRKQMVRNMNNKRRYSFRV--------------PEEERMQQRREMLRD-PEMR-NKLISNPTNFNHIAHMGPGDGIQIL 1555
BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Match: CDC42BPA (CDC42 binding protein kinase alpha [Source:NCBI gene;Acc:100497067]) HSP 1 Score: 677.167 bits (1746), Expect = 0.000e+0 Identity = 529/1646 (32.14%), Postives = 803/1646 (48.78%), Query Frame = 2
Query: 116 SVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPAL-LNGNHNESNSDALLEE-----VNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVT--------------DKEKLLTQCQ----------------NYDYSLR-----------EKEQKMDDLIETNRLL---NKERDELTSDRLQILQKKQDIEE---DLKVMTENF-NQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKE-KNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKE-IVKTSENSELLTELDREVELLKTLCVDND---------GDQK----------------------AQG----------ERQDNNGNES---------WRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEIC--------------DISKQLEKYKQDVNE------------KDNLIANLKSASQNLEPHVPKEIPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKC--YTRKSAGK-GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDP-HYRMIFTEKSCLNN-LDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
S+++E L+DSL C Y EC + +K++ +I+ K K++ +R+ + DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL S WIT LHYAFQD+ LY VMD+Y GGD+LTLLSKF DRLPE++++FY+AE+V++ID VH+L Y+HRDIKPDN+LLD GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ PT+ DVS+ A+DLI++LIC +E RLG GI+DFKNHPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N PP + F G HLP +GFT+T + + S+ SS+R S G P+ L+ N S D+L E + +L+ +L ++L E T +VQ H VT DK K L Q + +R EKE DL+E+N + KE E S R Q LQ+ ++ E +L+ + F QL+ + + LE L++ +KE + +++ D ++ +++ E+ QL SE + + K + ++NS Q Q I +K +++ K +F +E + H EI+ LK + + +S+ L N ++ L + E +S +E F +K D+E ++ EN +L +ELD+ + + L V+N D+K A+G E D N S W++R+ K D L L +E RA+ ++++L + K+ I D++ ++EK K + +E +++ +A L + + L+ H + SNP + + H F TFN P KC+ CTS M+G QG C+ C FSCH C ++ C T ++ G G + + GIGT YE +KVPKP G+++GW+R +CD KLF +++ EG + +S +VID++ EF V V +V+HA +KD+ I +++ + SS I +L +S K + V+ E +KK+ R ++ K ++ L + N + SAAI+D + G EEGL + VT ++G+ K V+ +E + + QL+AVI + R ++L LDG +VE K C V G+ V G + +C + K V Y LN TRH+K+++I +V + I E+L +G Y L GSP + L D +I Q +++ VEIS EYL+ F G++++ R++R +L WP P L C C PL S L+ G ++ I LIY A +++ + +T D +S + NKR+ S+ P + RD P ++ N+ IS P NF H++HMGP Q++
Sbjct: 23 SLSVESLLDSLLCLYDECSASPLRRDKHINDYIQWAKPFALKVKQMRLHKEDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---DSQWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMSRFYLAEMVLAIDSVHQLHYVHRDIKPDNILLDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQLADVSENAKDLIRRLICSREHRLGQNGIEDFKNHPFFVGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNCETMPPPTHTGFSGHHLPFVGFTYTSNCVL----SDRSSLRDAS-----GTPSTDLDANVQRSLEDSLATEAYERRIRRLEQEKVELTRKLQES-TQAVQ-ALQHSAVDGPVTASKDLEIKSLKEELDKLKTLGANQLTQQLDKSGLARPDFEEFSRQIRVFEKQVKVLKQEKEDLNKDLVESNEKMKTQTKELKEAQSQRKQALQEMAELNERLTELRSQKQKFVRQLRDKEEEMEAVAQKLEGLRQDLRRVERAKKELEAQMDSAASEASKDRKL-REKSEQYTKQLESELEGLKLKQVGRPLGVSNSEHQ--QEIAKLKTDLEK-KSVFYEEEFAKREALHAGEIKNLKKELRDAESQQLNLNKEILVLKDKLDKTRRESQSEREE-------FEAEMKQKFDRERLLLMEENKKLSSELDKLSAMFEKLSVNNRHLEEEMRDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELDTLRNSSLGAKPTDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKAKAAIIATECKLQESDKKNQDLTTEIEKLKWETDELRSEKGVKHQESQNSFLAFLNAPTSVLD-HFERSPSSNPASKGRRVRGCLALCAPPFLPPKAHQFVVKTFNAPTKCNQCTSLMVGLIRQGCTCEVCGFSCHVTC-ADKAPAVCPIPTDQTKGPLGIDPQKGIGTAYEGHVKVPKPAGVKKGWQRAMAVVCDFKLFLYEIAEGKSSQTSCVVS----QVIDMRDEEFAVSSVLASDVIHANRKDIPCIFRVTASQLSASSNKCSILLLADSESEKGKWVGVLNELHRILKKNKLKDRSVYVPKEAYDSTLPLIKNTQ---SAAILDHERIALGNEEGLFVVHVTKDEIIRVGDNKKVHQVELIPSE--QLIAVISGRNRHVRLYPMISLDGRETEFYKLVET-KGCQGIVSGQ--VRHGA------------------------LTCLCVSMKRQVLCYELNQSKTRHKKIKEIQVPGNVQWMAI--FNERLCVGYQSGFMRYPLHADGSP----YSLLHSDDHTLSFITQQATDAICAVEISNKEYLLCFSSVGVYVDCQGRRSRQQELMWPAGP---------LSC----------------CKCPAVRPLNSEGSLNILG---------LETIRLIYFKNKMAEGDELVVPETSD---NSRKQMVRNMNNKRRYSFRV--------------PEEERMQQRREMLRD-PEMR-NKLISNPTNFNHIAHMGPGDGIQIL 1546
BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Match: CDC42BPA (CDC42 binding protein kinase alpha [Source:NCBI gene;Acc:100497067]) HSP 1 Score: 673.315 bits (1736), Expect = 0.000e+0 Identity = 528/1645 (32.10%), Postives = 807/1645 (49.06%), Query Frame = 2
Query: 116 SVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPAL-LNGNHNESNSDALLEE-----VNQLKITCSQLEKQLNECRTNSVQRI----FSHPV--------------------------YQQL------VTDKEKLLTQCQNYDYSLR----EKEQKMDDLIETNRLL---NKERDELTSDRLQILQKKQDIEE---DLKVMTENF-NQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKE-KNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKE-IVKTSENSELLTELDREVELLKTLCVDND---------GDQK----------------------AQG----------ERQDNNGNES---------WRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEIC--------------DISKQLEKYKQDVNE------------KDNLIANLKSASQNLEPHVPKEIPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKC--YTRKSAGK-GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDP-HYRMIFTEKSCLNN-LDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
S+++E L+DSL C Y EC + +K++ +I+ K K++ +R+ + DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL S WIT LHYAFQD+ LY VMD+Y GGD+LTLLSKF DRLPE++++FY+AE+V++ID VH+L Y+HRDIKPDN+LLD GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ PT+ DVS+ A+DLI++LIC +E RLG GI+DFKNHPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N PP + F G HLP +GFT+T + + S+ SS+R S G P+ L+ N S D+L E + +L+ +L ++L E T +VQ + PV QQL D E+ Q + ++ ++ EKE DL+E+N + KE E S R Q LQ+ ++ E +L+ + F QL+ + + LE L++ +KE + +++ D ++ +++ E+ QL SE + + K + ++NS Q Q I +K +++ K +F +E + H EI+ LK + + +S+ L N ++ L + E +S +E F +K D+E ++ EN +L +ELD+ + + L V+N D+K A+G E D N S W++R+ K D L L +E RA+ ++++L + K+ I D++ ++EK K + +E +++ +A L + + L+ H + P + +S L H F TFN P KC+ CTS M+G QG C+ C FSCH C ++ C T ++ G G + + GIGT YE +KVPKP G+++GW+R +CD KLF +++ EG + +S +VID++ EF V V +V+HA +KD+ I +++ + SS I +L +S K + V+ E +KK+ R ++ K ++ L + N + SAAI+D + G EEGL + VT ++G+ K V+ +E + + QL+AVI + R ++L LDG +VE K C V G+ V G + +C + K V Y LN TRH+K+++I +V + I E+L +G Y L GSP + L D +I Q +++ VEIS EYL+ F G++++ R++R +L WP P L C C PL S L+ G ++ I LIY A +++ + +T D +S + NKR+ S+ P + RD P ++ N+ IS P NF H++HMGP Q++
Sbjct: 23 SLSVESLLDSLLCLYDECSASPLRRDKHINDYIQWAKPFALKVKQMRLHKEDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---DSQWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMSRFYLAEMVLAIDSVHQLHYVHRDIKPDNILLDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQLADVSENAKDLIRRLICSREHRLGQNGIEDFKNHPFFVGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNCETMPPPTHTGFSGHHLPFVGFTYTSNCVL----SDRSSLRDAS-----GTPSTDLDANVQRSLEDSLATEAYERRIRRLEQEKVELTRKLQES-TQAVQALQHSAVDGPVTASKDLEIKSLKEELDKLKTLGANQLTQQLDKSGLARPDFEEFSRQIRVFEKQVKVLKQEKEDLNKDLVESNEKMKTQTKELKEAQSQRKQALQEMAELNERLTELRSQKQKFVRQLRDKEEEMEAVAQKLEGLRQDLRRVERAKKELEAQMDSAASEASKDRKL-REKSEQYTKQLESELEGLKLKQVGRPLGVSNSEHQ--QEIAKLKTDLEK-KSVFYEEEFAKREALHAGEIKNLKKELRDAESQQLNLNKEILVLKDKLDKTRRESQSEREE-------FEAEMKQKFDRERLLLMEENKKLSSELDKLSAMFEKLSVNNRHLEEEMRDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELDTLRNSSLGAKPTDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKAKAAIIATECKLQESDKKNQDLTTEIEKLKWETDELRSEKGVKHQESQNSFLAFLNAPTSVLD-HFEVKTWFLPACSNTADSETCPLLVAVGAVPKAHQFVVKTFNAPTKCNQCTSLMVGLIRQGCTCEVCGFSCHVTC-ADKAPAVCPIPTDQTKGPLGIDPQKGIGTAYEGHVKVPKPAGVKKGWQRAMAVVCDFKLFLYEIAEGKSSQTSCVVS----QVIDMRDEEFAVSSVLASDVIHANRKDIPCIFRVTASQLSASSNKCSILLLADSESEKGKWVGVLNELHRILKKNKLKDRSVYVPKEAYDSTLPLIKNTQ---SAAILDHERIALGNEEGLFVVHVTKDEIIRVGDNKKVHQVELIPSE--QLIAVISGRNRHVRLYPMISLDGRETEFYKLVET-KGCQGIVSGQ--VRHGA------------------------LTCLCVSMKRQVLCYELNQSKTRHKKIKEIQVPGNVQWMAI--FNERLCVGYQSGFMRYPLHADGSP----YSLLHSDDHTLSFITQQATDAICAVEISNKEYLLCFSSVGVYVDCQGRRSRQQELMWPAGP---------LSC----------------CKCPAVRPLNSEGSLNILG---------LETIRLIYFKNKMAEGDELVVPETSD---NSRKQMVRNMNNKRRYSFRV--------------PEEERMQQRREMLRD-PEMR-NKLISNPTNFNHIAHMGPGDGIQIL 1546
BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Match: CDC42BPA (CDC42 binding protein kinase alpha [Source:NCBI gene;Acc:100497067]) HSP 1 Score: 671.774 bits (1732), Expect = 0.000e+0 Identity = 530/1670 (31.74%), Postives = 812/1670 (48.62%), Query Frame = 2
Query: 116 SVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPAL-LNGNHNESNSDALLEE-----VNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVT--------------DKEKLLTQCQ----------------NYDYSLR-----------EKEQKMDDLIETNRLL---NKERDELTSDRLQILQKKQDIEE---DLKVMTENF-NQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKE-KNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKE-IVKTSENSELLTELDREVELLKTLCVDND---------GDQK----------------------AQG----------ERQDNNGNES---------WRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEIC--------------DISKQLEKYKQDVNE------------KDNLIANLKSASQNLE---------------PHVPKEIPS-------NPVTLSEFN--SILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKC--YTRKSAGK-GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDP-HYRMIFTEKSCLNN-LDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
S+++E L+DSL C Y EC + +K++ +I+ K K++ +R+ + DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL S WIT LHYAFQD+ LY VMD+Y GGD+LTLLSKF DRLPE++++FY+AE+V++ID VH+L Y+HRDIKPDN+LLD GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ PT+ DVS+ A+DLI++LIC +E RLG GI+DFKNHPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N PP + F G HLP +GFT+T + + S+ SS+R S G P+ L+ N S D+L E + +L+ +L ++L E T +VQ H VT DK K L Q + +R EKE DL+E+N + KE E S R Q LQ+ ++ E +L+ + F QL+ + + LE L++ +KE + +++ D ++ +++ E+ QL SE + + K + ++NS Q Q I +K +++ K +F +E + H EI+ LK + + +S+ L N ++ L + E +S +E F +K D+E ++ EN +L +ELD+ + + L V+N D+K A+G E D N S W++R+ K D L L +E RA+ ++++L + K+ I D++ ++EK K + +E +++ +A L + + L+ P +++ S +P T+S+ + + ++ + H F TFN P KC+ CTS M+G QG C+ C FSCH C ++ C T ++ G G + + GIGT YE +KVPKP G+++GW+R +CD KLF +++ EG + +S +VID++ EF V V +V+HA +KD+ I +++ + SS I +L +S K + V+ E +KK+ R ++ K ++ L + N + SAAI+D + G EEGL + VT ++G+ K V+ +E + + QL+AVI + R ++L LDG +VE K C V G+ V G + +C + K V Y LN TRH+K+++I +V + I E+L +G Y L GSP + L D +I Q +++ VEIS EYL+ F G++++ R++R +L WP P L C C PL S L+ G ++ I LIY A +++ + +T D +S + NKR+ S+ P + RD P ++ N+ IS P NF H++HMGP Q++
Sbjct: 23 SLSVESLLDSLLCLYDECSASPLRRDKHINDYIQWAKPFALKVKQMRLHKEDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---DSQWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMSRFYLAEMVLAIDSVHQLHYVHRDIKPDNILLDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQLADVSENAKDLIRRLICSREHRLGQNGIEDFKNHPFFVGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNCETMPPPTHTGFSGHHLPFVGFTYTSNCVL----SDRSSLRDAS-----GTPSTDLDANVQRSLEDSLATEAYERRIRRLEQEKVELTRKLQES-TQAVQ-ALQHSAVDGPVTASKDLEIKSLKEELDKLKTLGANQLTQQLDKSGLARPDFEEFSRQIRVFEKQVKVLKQEKEDLNKDLVESNEKMKTQTKELKEAQSQRKQALQEMAELNERLTELRSQKQKFVRQLRDKEEEMEAVAQKLEGLRQDLRRVERAKKELEAQMDSAASEASKDRKL-REKSEQYTKQLESELEGLKLKQVGRPLGVSNSEHQ--QEIAKLKTDLEK-KSVFYEEEFAKREALHAGEIKNLKKELRDAESQQLNLNKEILVLKDKLDKTRRESQSEREE-------FEAEMKQKFDRERLLLMEENKKLSSELDKLSAMFEKLSVNNRHLEEEMRDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELDTLRNSSLGAKPTDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKAKAAIIATECKLQESDKKNQDLTTEIEKLKWETDELRSEKGVKHQESQNSFLAFLNAPTSVLDHFEMDSVDNFTLSNTPSRDEDVKSQGPSRSRSPSTMSDIEPPEVPAPTIGIELCTPKAHQFVVKTFNAPTKCNQCTSLMVGLIRQGCTCEVCGFSCHVTC-ADKAPAVCPIPTDQTKGPLGIDPQKGIGTAYEGHVKVPKPAGVKKGWQRAMAVVCDFKLFLYEIAEGKSSQTSCVVS----QVIDMRDEEFAVSSVLASDVIHANRKDIPCIFRVTASQLSASSNKCSILLLADSESEKGKWVGVLNELHRILKKNKLKDRSVYVPKEAYDSTLPLIKNTQ---SAAILDHERIALGNEEGLFVVHVTKDEIIRVGDNKKVHQVELIPSE--QLIAVISGRNRHVRLYPMISLDGRETEFYKLVET-KGCQGIVSGQ--VRHGA------------------------LTCLCVSMKRQVLCYELNQSKTRHKKIKEIQVPGNVQWMAI--FNERLCVGYQSGFMRYPLHADGSP----YSLLHSDDHTLSFITQQATDAICAVEISNKEYLLCFSSVGVYVDCQGRRSRQQELMWPAGP---------LSC----------------CKCPAVRPLNSEGSLNILG---------LETIRLIYFKNKMAEGDELVVPETSD---NSRKQMVRNMNNKRRYSFRV--------------PEEERMQQRREMLRD-PEMR-NKLISNPTNFNHIAHMGPGDGIQIL 1571
BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Match: CDC42BPA (CDC42 binding protein kinase alpha [Source:NCBI gene;Acc:100497067]) HSP 1 Score: 669.848 bits (1727), Expect = 0.000e+0 Identity = 525/1627 (32.27%), Postives = 806/1627 (49.54%), Query Frame = 2
Query: 116 SVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPAL-LNGNHNESNSDALLEEVNQLKITCSQLEK-QLNECRTNSVQRIF-----SHPVYQQL------VTDKEKLLTQCQNYDYSLR----EKEQKMDDLIETNRLL---NKERDELTSDRLQILQKKQDIEE---DLKVMTENF-NQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKE-KNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKE-IVKTSENSELLTELDREVELLKTLCVDND---------GDQK----------------------AQG----------ERQDNNGNES---------WRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEIC--------------DISKQLEKYKQDVNEKDN------LIANLKSASQNLE-----------------PHVPKEIPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKC--YTRKSAGK-GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDP-HYRMIFTEKSCLNN-LDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
S+++E L+DSL C Y EC + +K++ +I+ K K++ +R+ + DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL S WIT LHYAFQD+ LY VMD+Y GGD+LTLLSKF DRLPE++++FY+AE+V++ID VH+L Y+HRDIKPDN+LLD GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ PT+ DVS+ A+DLI++LIC +E RLG GI+DFKNHPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N PP + F G HLP +GFT+T + + S+ SS+R S G P+ L+ N S D+L E + +I + EK +L V F ++ + QQL D E+ Q + ++ ++ EKE DL+E+N + KE E S R Q LQ+ ++ E +L+ + F QL+ + + LE L++ +KE + +++ D ++ +++ E+ QL SE + + K + ++NS Q Q I +K +++ K +F +E + H EI+ LK + + +S+ L N ++ L + E +S +E F +K D+E ++ EN +L +ELD+ + + L V+N D+K A+G E D N S W++R+ K D L L +E RA+ ++++L + K+ I D++ ++EK K + +E + ++ S + +IP +P + N +G K H F TFN P KC+ CTS M+G QG C+ C FSCH C ++ C T ++ G G + + GIGT YE +KVPKP G+++GW+R +CD KLF +++ EG + +S +VID++ EF V V +V+HA +KD+ I +++ + SS I +L +S K + V+ E +KK+ R ++ K ++ L + N + SAAI+D + G EEGL + VT ++G+ K V+ +E + + QL+AVI + R ++L LDG +VE K C V G+ V G + +C + K V Y LN TRH+K+++I +V + I E+L +G Y L GSP + L D +I Q +++ VEIS EYL+ F G++++ R++R +L WP P L C +I E S + +PL+ G + ++ I LIY + K+ + +TS ++ + + +N NK+ SF P + RD P ++ N+ IS P NF H++HMGP Q++
Sbjct: 23 SLSVESLLDSLLCLYDECSASPLRRDKHINDYIQWAKPFALKVKQMRLHKEDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---DSQWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMSRFYLAEMVLAIDSVHQLHYVHRDIKPDNILLDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQLADVSENAKDLIRRLICSREHRLGQNGIEDFKNHPFFVGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNCETMPPPTHTGFSGHHLPFVGFTYTSNCVL----SDRSSLRDAS-----GTPSTDLDANVQRSLEDSLATEAYERRIRRLEQEKVELTRKLQGLVTDFFFCSVGANQLTQQLDKSGLARPDFEEFSRQIRVFEKQVKVLKQEKEDLNKDLVESNEKMKTQTKELKEAQSQRKQALQEMAELNERLTELRSQKQKFVRQLRDKEEEMEAVAQKLEGLRQDLRRVERAKKELEAQMDSAASEASKDRKL-REKSEQYTKQLESELEGLKLKQVGRPLGVSNSEHQ--QEIAKLKTDLEK-KSVFYEEEFAKREALHAGEIKNLKKELRDAESQQLNLNKEILVLKDKLDKTRRESQSEREE-------FEAEMKQKFDRERLLLMEENKKLSSELDKLSAMFEKLSVNNRHLEEEMRDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELDTLRNSSLGAKPTDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKAKAAIIATECKLQESDKKNQDLTTEIEKLKWETDELRSEKGIWPIMWGFSSQHSKIWGGNVYILCGVTVTLYCCAASWSDIPPSPPAADQQN---NGKGPKA------HQFVVKTFNAPTKCNQCTSLMVGLIRQGCTCEVCGFSCHVTC-ADKAPAVCPIPTDQTKGPLGIDPQKGIGTAYEGHVKVPKPAGVKKGWQRAMAVVCDFKLFLYEIAEGKSSQTSCVVS----QVIDMRDEEFAVSSVLASDVIHANRKDIPCIFRVTASQLSASSNKCSILLLADSESEKGKWVGVLNELHRILKKNKLKDRSVYVPKEAYDSTLPLIKNTQ---SAAILDHERIALGNEEGLFVVHVTKDEIIRVGDNKKVHQVELIPSE--QLIAVISGRNRHVRLYPMISLDGRETEFYKLVET-KGCQGIVSGQ--VRHGA------------------------LTCLCVSMKRQVLCYELNQSKTRHKKIKEIQVPGNVQWMAI--FNERLCVGYQSGFMRYPLHADGSP----YSLLHSDDHTLSFITQQATDAICAVEISNKEYLLCFSSVGVYVDCQGRRSRQQELMWPAGP---------LSC----CKCPGQDIRETSWTV---------RPLNSEGSLNILG---LETIRLIYF------KNKMGDELVVPETSDNSRKQMVRNMN------NKRRYSFRV-------PEEERMQQRREMLRD-PEMR-NKLISNPTNFNHIAHMGPGDGIQIL 1528
BLAST of Serine/threonine kinase vs. Ensembl Mouse
Match: Cdc42bpa (CDC42 binding protein kinase alpha [Source:MGI Symbol;Acc:MGI:2441841]) HSP 1 Score: 687.182 bits (1772), Expect = 0.000e+0 Identity = 517/1644 (31.45%), Postives = 809/1644 (49.21%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSV-PDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREK-------EQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAI-----NRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEK--------QRFE----------EVMLQLRSENDQMLEKMRLKCSNLTNSLE----------------QSDQTIFNIKEEIKSLKEIFTNKEKNLKLS-HDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKTLCVDND---------GDQK---AQGERQ------------DNNG-----------------NES---------WRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNL-----IANLKSASQNLEPHVPKEIPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGKGA---NLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHY-RMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
MS ++ L+Q +++F+L+ + ++E L+D L C Y EC + EKN+ ++++ K K++ +R+ R DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL S WIT LHYAFQD+ LY VMD+Y GGD+LTLLSKF DRLPEE+ +FY+AE+V++ID VH+L Y+HRDIKPDN+L+D GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ P + DVS+ A+DLI++LIC +E RLG GI+DFK HPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N+ PP + F G HLP +GFT+T + ++ + SL ++ L+ N + ++ + Q K+ +L ++L E T +VQ + V L K+ + + LR++ EQ++++ R L+ ++ + QI +Q+ EE K + + +LK+ +K + R+ + EF + + +++ ++ + + D+ ++K +R E E ++ S++ ++ E+ L N LE + Q I +K +++ K IF +E + + H +EI+ LK + + + + LA N ++ L + E +S +E N+ + + R K +L T EN +L +ELD+ L ++L + N D+K A E Q D G N S W++R+ K D L L +E RA+ ++++L + K+ S L + K +EK NL I L ++ L E + + F + + +LD+ H F +F P KC CTS M+G QG C+ C FSCH C+ N C KG + + G+GT YE +++PKP G+++GW+R +CD KLF +D+ EG IS +VID++ EF V V +V+HA +KD+ I +++ + S I +L +S + + + V+ E +KK+ R ++ K ++ + Q +AAIID + G EEGL + VT ++G+ K ++ IE + QLVAVI + R ++L LDG + + + K C T GK V G + +C A K V Y L TRH K ++I +V + I E L +G Y L G P L D +I +++ VEIS EYL+ F GI+ + R++R +L WP P+ Y APYL ++E A + +++ +S +Q LPL+ +PL+ G + ++ I LIY A +++ + +T D + +I NKR+ S+ P + RD P ++ N+ IS P NF H++HMGP Q++
Sbjct: 1 MSGEVRLRQ-----LEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---DSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVSVQRTLDNNLATEAYERRIKRLEQEKL---ELTRKLQES-TQTVQALQYSTVDGPLTASKDLEIKSLKEEIEKLRKQVAEVNHLEQQLEEANSVRRELDDAFRQIKASEKQIKTLQQEREELNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKAESLRQELRRAERAKKELEVHTEALIAEASKDKKLREQSEHYSKQLENELEGLKQKQISYSPGICSIEHQQEITKLKTDLEK-KSIFYEEEISKREGIHASEIKNLKKELHDSEGQQLALNKEILVLKDKLEKTRRESQSEREEFENEFKQQYEREKVLL------TEENKKLTSELDKLTSLYESLSLRNQHLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKA-----SNILTECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTPTDALDQ--FERKTHQFFVKSFTAPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCV-NKAPTVCPVPPEQTKGPLGIDPQKGVGTAYEGHVRIPKPAGVKKGWQRALAVVCDFKLFLYDIAEGKASQPTSVIS----QVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSAPSNKCSILMLADSENERSKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQ--AAAIIDHERIALGNEEGLFVVHVTKDEIVRVGDNKKIHQIELIPSD--QLVAVISGRNRHVRLFPMSALDG-RETDFYKLAETKGCQTIAAGK--VRHGA------------------------LSCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPCNVQWMAI--FSEHLCVGFQSGFLRYPLNGEGGP----CNMLHSNDHTLSFISHQPMDALCAVEISNKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENA-VDIFDV--NSMEWIQTLPLKKVRPLNTEGSLNLLG---LETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNIN---NKRRYSFRV--------------PEEERMQQRREMLRD-PEMR-NKLISNPTNFNHIAHMGPGDGIQIL 1551
BLAST of Serine/threonine kinase vs. Ensembl Mouse
Match: Cdc42bpa (CDC42 binding protein kinase alpha [Source:MGI Symbol;Acc:MGI:2441841]) HSP 1 Score: 681.404 bits (1757), Expect = 0.000e+0 Identity = 504/1595 (31.60%), Postives = 794/1595 (49.78%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSV-PDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREK-------EQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEE--DLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIF--TNKE-KNLKLSHDNEIEQL----KISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKF-HFRLKTILDKEIVKTSENSE-----LLTELDREVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNL-----IANLKSASQNLEPHVPKEIPSNPVTLSEFNSILSGSLDK-TVVNC-------------------------NQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGKGA---NLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHY-RMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
MS ++ L+Q +++F+L+ + ++E L+D L C Y EC + EKN+ ++++ K K++ +R+ R DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL S WIT LHYAFQD+ LY VMD+Y GGD+LTLLSKF DRLPEE+ +FY+AE+V++ID VH+L Y+HRDIKPDN+L+D GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ P + DVS+ A+DLI++LIC +E RLG GI+DFK HPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N+ PP + F G HLP +GFT+T + ++ + SL ++ L+ N + ++ + Q K+ +L ++L E T +VQ + V L K+ + + LR++ EQ++++ R L+ ++ + QI +Q+ EE L+V TE S +K + RE+ + + + + +K+K+ I + Q +I K E+ + E + + NL L S+ + +EI LK+ T +E ++ + +NE +Q K+ + EE ++ + +L S +SLS N L ++++++K H+ + + V +++ L +++ E+E L+ + G R + W++R+ K D L L +E RA+ ++++L + K+ S L + K +EK NL I L ++ L E + + F + + +LD+ + +C H F +F P KC CTS M+G QG C+ C FSCH C+ N C KG + + G+GT YE +++PKP G+++GW+R +CD KLF +D+ EG IS +VID++ EF V V +V+HA +KD+ I +++ + S I +L +S + + + V+ E +KK+ R ++ K ++ + Q +AAIID + G EEGL + VT ++G+ K ++ IE + QLVAVI + R ++L LDG + + + K C T GK + + +C A K V Y L TRH K ++I +V + I E L +G Y L G P L D +I +++ VEIS EYL+ F GI+ + R++R +L WP P+ Y APYL ++E A + +++ +S +Q LPL+ +PL+ G + ++ I LIY A +++ + +T D + +I NKR+ S+ P + RD P ++ N+ IS P NF H++HMGP Q++
Sbjct: 1 MSGEVRLRQ-----LEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---DSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVSVQRTLDNNLATEAYERRIKRLEQEKL---ELTRKLQES-TQTVQALQYSTVDGPLTASKDLEIKSLKEEIEKLRKQVAEVNHLEQQLEEANSVRRELDDAFRQIKASEKQIKTLQQEREELNKLEVHTEALIAEASKDKKL-REQSEHYSKQLENELEGLKQKQISYSPGICSIEHQQEITKLKTDLEKKSIFYEEEISKREGIHASEIKNLKKELHDSEGQQLALNKEILVLKDKLEKTRRESQSEREEFENEFKQQYEREKVLLTEENKKLTSELDKLTSLYESLSLRNQHLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRN---------SSLGTRATDM---PWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKA-----SNILTECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTPTDALDQFEIADCAPLPAHTPTLRKKGCPASTGFPPKRKTHQFFVKSFTAPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCV-NKAPTVCPVPPEQTKGPLGIDPQKGVGTAYEGHVRIPKPAGVKKGWQRALAVVCDFKLFLYDIAEGKASQPTSVIS----QVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSAPSNKCSILMLADSENERSKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQ--AAAIIDHERIALGNEEGLFVVHVTKDEIVRVGDNKKIHQIELIPSD--QLVAVISGRNRHVRLFPMSALDG-RETDFYKLAETKGCQTIAAGKV--------------------------RHGALSCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPCNVQWMAI--FSEHLCVGFQSGFLRYPLNGEGGP----CNMLHSNDHTLSFISHQPMDALCAVEISNKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENA-VDIFDV--NSMEWIQTLPLKKVRPLNTEGSLNLLG---LETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNIN---NKRRYSFRV--------------PEEERMQQRREMLRD-PEMR-NKLISNPTNFNHIAHMGPGDGIQIL 1498
BLAST of Serine/threonine kinase vs. Ensembl Mouse
Match: Cdc42bpa (CDC42 binding protein kinase alpha [Source:MGI Symbol;Acc:MGI:2441841]) HSP 1 Score: 680.248 bits (1754), Expect = 0.000e+0 Identity = 516/1670 (30.90%), Postives = 811/1670 (48.56%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSV-PDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREK-------EQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAI-----NRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEK--------QRFE----------EVMLQLRSENDQMLEKMRLKCSNLTNSLE----------------QSDQTIFNIKEEIKSLKEIFTNKEKNLKLS-HDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKTLCVDND---------GDQK---AQGERQ------------DNNG--------------------------NESWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNL-----IANLKSASQNLEPHVPKEIPSNPVTLSEFNSILSGSLDK-TVVNC-------------------------NQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGKGA---NLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHY-RMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
MS ++ L+Q +++F+L+ + ++E L+D L C Y EC + EKN+ ++++ K K++ +R+ R DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL S WIT LHYAFQD+ LY VMD+Y GGD+LTLLSKF DRLPEE+ +FY+AE+V++ID VH+L Y+HRDIKPDN+L+D GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ P + DVS+ A+DLI++LIC +E RLG GI+DFK HPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N+ PP + F G HLP +GFT+T + ++ + SL ++ L+ N + ++ + Q K+ +L ++L E T +VQ + V L K+ + + LR++ EQ++++ R L+ ++ + QI +Q+ EE K + + +LK+ +K + R+ + EF + + +++ ++ + + D+ ++K +R E E ++ S++ ++ E+ L N LE + Q I +K +++ K IF +E + + H +EI+ LK + + + + LA N ++ L + E +S +E N+ + + R K +L T EN +L +ELD+ L ++L + N D+K A E Q D G + W++R+ K D L L +E RA+ ++++L + K+ S L + K +EK NL I L ++ L E + + F + + +LD+ + +C H F +F P KC CTS M+G QG C+ C FSCH C+ N C KG + + G+GT YE +++PKP G+++GW+R +CD KLF +D+ EG IS +VID++ EF V V +V+HA +KD+ I +++ + S I +L +S + + + V+ E +KK+ R ++ K ++ + Q +AAIID + G EEGL + VT ++G+ K ++ IE + QLVAVI + R ++L LDG + + + K C T GK V G + +C A K V Y L TRH K ++I +V + I E L +G Y L G P L D +I +++ VEIS EYL+ F GI+ + R++R +L WP P+ Y APYL ++E A + +++ +S +Q LPL+ +PL+ G + ++ I LIY A +++ + +T D + +I NKR+ S+ P + RD P ++ N+ IS P NF H++HMGP Q++
Sbjct: 1 MSGEVRLRQ-----LEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---DSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVSVQRTLDNNLATEAYERRIKRLEQEKL---ELTRKLQES-TQTVQALQYSTVDGPLTASKDLEIKSLKEEIEKLRKQVAEVNHLEQQLEEANSVRRELDDAFRQIKASEKQIKTLQQEREELNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKAESLRQELRRAERAKKELEVHTEALIAEASKDKKLREQSEHYSKQLENELEGLKQKQISYSPGICSIEHQQEITKLKTDLEK-KSIFYEEEISKREGIHASEIKNLKKELHDSEGQQLALNKEILVLKDKLEKTRRESQSEREEFENEFKQQYEREKVLL------TEENKKLTSELDKLTSLYESLSLRNQHLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKA-----SNILTECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTPTDALDQFEIADCAPLPAHTPTLRKKGCPASTGFPPKRKTHQFFVKSFTAPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCV-NKAPTVCPVPPEQTKGPLGIDPQKGVGTAYEGHVRIPKPAGVKKGWQRALAVVCDFKLFLYDIAEGKASQPTSVIS----QVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSAPSNKCSILMLADSENERSKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQ--AAAIIDHERIALGNEEGLFVVHVTKDEIVRVGDNKKIHQIELIPSD--QLVAVISGRNRHVRLFPMSALDG-RETDFYKLAETKGCQTIAAGK--VRHGA------------------------LSCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPCNVQWMAI--FSEHLCVGFQSGFLRYPLNGEGGP----CNMLHSNDHTLSFISHQPMDALCAVEISNKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENA-VDIFDV--NSMEWIQTLPLKKVRPLNTEGSLNLLG---LETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNIN---NKRRYSFRV--------------PEEERMQQRREMLRD-PEMR-NKLISNPTNFNHIAHMGPGDGIQIL 1579
BLAST of Serine/threonine kinase vs. Ensembl Mouse
Match: Cdc42bpa (CDC42 binding protein kinase alpha [Source:MGI Symbol;Acc:MGI:2441841]) HSP 1 Score: 649.432 bits (1674), Expect = 0.000e+0 Identity = 506/1679 (30.14%), Postives = 805/1679 (47.95%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSV-PDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREK-------EQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAI-----NRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEK--------QRFE----------EVMLQLRSENDQMLEKMRLKCSNLTNSLE----------------QSDQTIFNIKEEIKSLKEIFTNKEKNLKLS-HDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKTLCVDND---------GDQK---AQGERQ------------DNNG--------------------------NESWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSE----ICDISKQLEKYKQDVNEKDNLIANL------KSASQNLEPHVPKEIPSNPV-TLSEFN---SILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTS---------HMLGQYYQGVKCKECS-----------------FSCHHYCLSNVLNDKCYTRKSAGKGA---NLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHY-RMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
MS ++ L+Q +++F+L+ + ++E L+D L C Y EC + EKN+ ++++ K K++ +R+ R DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL S WIT LHYAFQD+ LY VMD+Y GGD+LTLLSKF DRLPEE+ +FY+AE+V++ID VH+L Y+HRDIKPDN+L+D GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ P + DVS+ A+DLI++LIC +E RLG GI+DFK HPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N+ PP + F G HLP +GFT+T + ++ + SL ++ L+ N + ++ + Q K+ +L ++L E T +VQ + V L K+ + + LR++ EQ++++ R L+ ++ + QI +Q+ EE K + + +LK+ +K + R+ + EF + + +++ ++ + + D+ ++K +R E E ++ S++ ++ E+ L N LE + Q I +K +++ K IF +E + + H +EI+ LK + + + + LA N ++ L + E +S +E N+ + + R K +L T EN +L +ELD+ L ++L + N D+K A E Q D G + W++R+ K D L L +E RA+ ++++L + K+ C + +K + ++E + LI + K H + P L +F S S + + +C + +H+ R C T + + KC +C+ FSCH C+ N C KG + + G+GT YE +++PKP G+++GW+R +CD KLF +D+ EG IS +VID++ EF V V +V+HA +KD+ I +++ + S I +L +S + + + V+ E +KK+ R ++ K ++ + Q +AAIID + G EEGL + VT ++G+ K ++ IE + QLVAVI + R ++L LDG + + + K C T GK V G + +C A K V Y L TRH K ++I +V + I E L +G Y L G P L D +I +++ VEIS EYL+ F GI+ + R++R +L WP P+ Y APYL ++E A + +++ +S +Q LPL+ +PL+ G + ++ I LIY A +++ + +T D + +I NKR+ S+ P + RD P ++ N+ IS P NF H++HMGP Q++
Sbjct: 1 MSGEVRLRQ-----LEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---DSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVSVQRTLDNNLATEAYERRIKRLEQEKL---ELTRKLQES-TQTVQALQYSTVDGPLTASKDLEIKSLKEEIEKLRKQVAEVNHLEQQLEEANSVRRELDDAFRQIKASEKQIKTLQQEREELNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKAESLRQELRRAERAKKELEVHTEALIAEASKDKKLREQSEHYSKQLENELEGLKQKQISYSPGICSIEHQQEITKLKTDLEK-KSIFYEEEISKREGIHASEIKNLKKELHDSEGQQLALNKEILVLKDKLEKTRRESQSEREEFENEFKQQYEREKVLL------TEENKKLTSELDKLTSLYESLSLRNQHLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNILTECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTPTDALDQFERSPSCTPASKGRRIADCAP-LPAHTPTLRKKGCPASTGFPPKRKTHQFFVKSFTAPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCV-NKAPTVCPVPPEQTKGPLGIDPQKGVGTAYEGHVRIPKPAGVKKGWQRALAVVCDFKLFLYDIAEGKASQPTSVIS----QVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSAPSNKCSILMLADSENERSKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQ--AAAIIDHERIALGNEEGLFVVHVTKDEIVRVGDNKKIHQIELIPSD--QLVAVISGRNRHVRLFPMSALDG-RETDFYKLAETKGCQTIAAGK--VRHGA------------------------LSCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPCNVQWMAI--FSEHLCVGFQSGFLRYPLNGEGGP----CNMLHSNDHTLSFISHQPMDALCAVEISNKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENA-VDIFDV--NSMEWIQTLPLKKVRPLNTEGSLNLLG---LETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNIN---NKRRYSFRV--------------PEEERMQQRREMLRD-PEMR-NKLISNPTNFNHIAHMGPGDGIQIL 1592
BLAST of Serine/threonine kinase vs. Ensembl Mouse
Match: Cdc42bpb (CDC42 binding protein kinase beta [Source:MGI Symbol;Acc:MGI:2136459]) HSP 1 Score: 593.964 bits (1530), Expect = 0.000e+0 Identity = 452/1539 (29.37%), Postives = 770/1539 (50.03%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSL---------MENI-----------------------------------GAPALLNGNHNESNSDALLEEVNQLK---ITCSQLEKQLNECRT------NSVQRIFS------------HPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXH--------------LSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQML-----EKMR------LKCSNLTNSLEQSDQTIFNIKEEIKSLKEIF--TNKEKNLKLSH-----DNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKF-HFRLKTILDKEIVKTSENSE-----LLTELDREVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQK---------------------SEICDISKQLE-KYKQDVNEK------------------DNLIANLKSAS--------QNLEPHV--------------PKEIPSNPVTLSEFNSI-LSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGK---GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHYRMI--FTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTR-PDLQW 4105
MS K+ LK+ +++ LL+ ++++E L+D L C Y EC + +K VA+F++ K ++ +++ R DF+ I+VIGRGAFG+V+VV+ K IYAMK L+K+++LK+ + ACF+EERDVL WIT LHYAFQDE YLY VMD+Y GGD+LTLLSKF D+LPE++ +FYI E+V++ID +H+L Y+HRDIKPDN+LLD GHI LADFGSC+K+ +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN E FQ P+ DVS+EA+DLI++LIC +E RLG GI+DFK H FF ++W+N+R+ AP+IP+VSS DTSNF+ DD N P + F G HLP IGFTFT + F++ GS +S + +L +EN G+ L ++ + L EE+ ++K ++LE+QL + T +S R+ +++QLV E+L +Q + + +++++ + + E LN+ EL S + ++ ++ +D EE+++V + + ++ + + + LE L+ + KE++ +H L +++ P E Q + + ++RSE ++ + E +R L+ N+ + S+ +++E+ LK+ + +E++ ++ ++ E+ + + +E ++ A N +L S V L+ +N +L LQ++++K H+ + + V +++ L +++ E+E L++ + G R + W++R+ K D L L++E RA+ ++++L + K E+ + K++E K++ D K +L SAS +L P V P++ PS PV L ++ ++G K H FS +F P +C +CTS M+G QG C+ C+FSCH C + C K G +++ GIGT Y+ ++KVPKP G+++GW+R + +CD KLF +D+ EG + TQ P + + +V+DL+ EF V V +V+HA ++D+ I +++ + + S + +L E+ + K + ++E ++ + K+ + +++ ++L + + +L+AAI+D + G EEGL +++T + + K VY IE + K+++ +LL G H + P +G + F + K + G Q ++A T S + + A K + Y + H K +++ V + + ++L +G ++ S+ G P + D + ++ Q +F+++ VE+ EYL+ F G++++ R++R +L W
Sbjct: 1 MSAKVRLKK-----LEQLLLDGPWRNDSALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKDMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNG---DCQWITALHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDMLRNIEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSMTQSNTLTKDEDVQRDLENSLQIEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSTRALGNSNRDKEIKRLNEELERMKSKMADSNRLERQLEDTVTLRQEHEDSTHRLKGLEKQYRLARQEKEELHKQLVEASERLKSQTKELKDAHQQRKRALQEFSE----LNERMSELRSLKQKVSRQLRDKEEEMEVAMQKIDSMRQDLRKSEKSRKELEARLEDAAAEASKERKLREHSESFCKQMERELEALKVKQGGRGPGAASEHQ---QEISKIRSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQLALQKEVLMLKDKLEKSKRERHSEMEEAIGTVKDKYERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDELQDLASKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELETLRSSSL---------GSR---TLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEELRKVKDSSLAFESKLKESEAKNRELLEEMQSLRKRMEEKFRADTGLKLPDFQDSIFEYFNTAPLAHDLTFRTSSASDQETQASKMDLSPSVSVATSTEQQEDMARPQQRPS-PVPLPSTQALAMAGPKPKA------HQFSIKSFPSPTQCSHCTSLMVGLIRQGYACEVCAFSCHVSC-KDSAPQVCPIPPEQSKRPLGVDVQRGIGTAYKGYVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKS-TQ-PGVVAS--QVLDLRDEEFAVSSVLASDVIHATRRDIPCIFRVTASLLGSPSKTSSLLILTENENEKRKWVGILEGLQAILHKNRLKSQVVHVAQEAYDSSLPL---IKAVLAAAIVDGDRIAVGLEEGLYVIELTRDVIVRAADCKKVYQIE------------LAPKEKI-AILLCGRNHHVHLY-PWSSFDGAEASNFDI-KLPETKGCQ-------LIATGTLRKSSST-----CLFVAVKRLILCYEIQRTKPFHRKFSELVAPGHVQWMAV--FKDRLCVGYPSGFSLLSIQGDGPP----LDLVNPTDPSLAFLSQQSFDALCAVELKSEEYLLCFSHMGLYVDPQGRRSRMQELMW 1464
BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q3UU96|MRCKA_MOUSE (Serine/threonine-protein kinase MRCK alpha OS=Mus musculus OX=10090 GN=Cdc42bpa PE=1 SV=2) HSP 1 Score: 680.248 bits (1754), Expect = 0.000e+0 Identity = 516/1670 (30.90%), Postives = 811/1670 (48.56%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSV-PDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREK-------EQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAI-----NRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEK--------QRFE----------EVMLQLRSENDQMLEKMRLKCSNLTNSLE----------------QSDQTIFNIKEEIKSLKEIFTNKEKNLKLS-HDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKTLCVDND---------GDQK---AQGERQ------------DNNG--------------------------NESWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNL-----IANLKSASQNLEPHVPKEIPSNPVTLSEFNSILSGSLDK-TVVNC-------------------------NQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGKGA---NLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHY-RMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
MS ++ L+Q +++F+L+ + ++E L+D L C Y EC + EKN+ ++++ K K++ +R+ R DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL S WIT LHYAFQD+ LY VMD+Y GGD+LTLLSKF DRLPEE+ +FY+AE+V++ID VH+L Y+HRDIKPDN+L+D GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ P + DVS+ A+DLI++LIC +E RLG GI+DFK HPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N+ PP + F G HLP +GFT+T + ++ + SL ++ L+ N + ++ + Q K+ +L ++L E T +VQ + V L K+ + + LR++ EQ++++ R L+ ++ + QI +Q+ EE K + + +LK+ +K + R+ + EF + + +++ ++ + + D+ ++K +R E E ++ S++ ++ E+ L N LE + Q I +K +++ K IF +E + + H +EI+ LK + + + + LA N ++ L + E +S +E N+ + + R K +L T EN +L +ELD+ L ++L + N D+K A E Q D G + W++R+ K D L L +E RA+ ++++L + K+ S L + K +EK NL I L ++ L E + + F + + +LD+ + +C H F +F P KC CTS M+G QG C+ C FSCH C+ N C KG + + G+GT YE +++PKP G+++GW+R +CD KLF +D+ EG IS +VID++ EF V V +V+HA +KD+ I +++ + S I +L +S + + + V+ E +KK+ R ++ K ++ + Q +AAIID + G EEGL + VT ++G+ K ++ IE + QLVAVI + R ++L LDG + + + K C T GK V G + +C A K V Y L TRH K ++I +V + I E L +G Y L G P L D +I +++ VEIS EYL+ F GI+ + R++R +L WP P+ Y APYL ++E A + +++ +S +Q LPL+ +PL+ G + ++ I LIY A +++ + +T D + +I NKR+ S+ P + RD P ++ N+ IS P NF H++HMGP Q++
Sbjct: 1 MSGEVRLRQ-----LEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---DSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVSVQRTLDNNLATEAYERRIKRLEQEKL---ELTRKLQES-TQTVQALQYSTVDGPLTASKDLEIKSLKEEIEKLRKQVAEVNHLEQQLEEANSVRRELDDAFRQIKASEKQIKTLQQEREELNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKAESLRQELRRAERAKKELEVHTEALIAEASKDKKLREQSEHYSKQLENELEGLKQKQISYSPGICSIEHQQEITKLKTDLEK-KSIFYEEEISKREGIHASEIKNLKKELHDSEGQQLALNKEILVLKDKLEKTRRESQSEREEFENEFKQQYEREKVLL------TEENKKLTSELDKLTSLYESLSLRNQHLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKA-----SNILTECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTPTDALDQFEIADCAPLPAHTPTLRKKGCPASTGFPPKRKTHQFFVKSFTAPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCV-NKAPTVCPVPPEQTKGPLGIDPQKGVGTAYEGHVRIPKPAGVKKGWQRALAVVCDFKLFLYDIAEGKASQPTSVIS----QVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSAPSNKCSILMLADSENERSKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQ--AAAIIDHERIALGNEEGLFVVHVTKDEIVRVGDNKKIHQIELIPSD--QLVAVISGRNRHVRLFPMSALDG-RETDFYKLAETKGCQTIAAGK--VRHGA------------------------LSCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPCNVQWMAI--FSEHLCVGFQSGFLRYPLNGEGGP----CNMLHSNDHTLSFISHQPMDALCAVEISNKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENA-VDIFDV--NSMEWIQTLPLKKVRPLNTEGSLNLLG---LETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNIN---NKRRYSFRV--------------PEEERMQQRREMLRD-PEMR-NKLISNPTNFNHIAHMGPGDGIQIL 1579
BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q9Y5S2|MRCKB_HUMAN (Serine/threonine-protein kinase MRCK beta OS=Homo sapiens OX=9606 GN=CDC42BPB PE=1 SV=2) HSP 1 Score: 629.017 bits (1621), Expect = 0.000e+0 Identity = 502/1703 (29.48%), Postives = 823/1703 (48.33%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD--FNANHEGPPLS-SNFKGCHLPCIGFTFTKDFIFNEMGSEES-------------------SVRLKSLMENI-------------------------GAPALLNGNHNESNSDALLEEVNQLK---ITCSQLEKQLNEC------RTNSVQRIFS----HPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNRL-------LNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXH--------------LSIQKN--------QSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQL-----------KISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKF-HFRLKTILDKEIVKTSENSE-----LLTELDREVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARA--------------DLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIANLK---------------------------SASQNLEPHVPKEIPSNPVTLSEFNSILS--------------GSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGK---GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHYRMIFTEKSCLNNLDISMNY-RQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRP-DLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGK-TIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQ-LIDL 4618
MS K+ LK+ +++ LL+ ++++E L+D L C Y EC + +K VA+F++ K ++ +++ R DF+ I+VIGRGAFG+V+VV+ K IYAMK L+K+++LK+ + ACF+EERDVL WIT LHYAFQDE +LY VMD+Y GGD+LTLLSKF D+LPE++ +FYI E+V++ID +H+L Y+HRDIKPDN+LLD GHI LADFGSC+K+ +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN E FQ P+ DVS+EA+DLI++LIC +E RLG GI+DFK H FF ++W+N+R+ AP+IP+VSS DTSNF+ DD PP S + F G HLP IGFTFT + F++ GS +S S+++++ I G+ L+ ++ + L EE+ +LK ++LE+QL + R +S QR+ H V +Q +KE+L Q L+ + +++ D + +L LN+ EL + + ++ ++ +D EE+++V T+ + ++ + + + LE +LD + KE++ +H L +++ + Q +I K E+ +L E + L+ N+ + S+ +++EI LK+ EK+ + H NE+E+ + + +E ++ A N +L S V L+ +N +L LQ+++ K H+ + + V +++ L +++ E+E L++ + G R + W++R+ K D L L++E RA+ LE KL +++ ++ +++E K+ + EK LK ++ Q + P+ PS V SE ++ +L H FS +F+ P +C +CTS M+G QG C+ CSF+CH C C K G +++ GIGT Y+ +KVPKP G+++GW+R + +CD KLF +D+ EG + TQ I+ +V+DL+ EF V V +V+HA ++D+ I +++ + S + +L E+ + K + ++E +S + K+ + L D S+ + IL+AAI+D + G EEGL ++VT + + K V+ IE ++ ++V ++ + + L LDGA I + K C ++A +T S + + A K + Y + H K +I+ SV L + ++L +G + S+ G P + D + ++ Q +F+++ VE+ EYL+ F G++++ R+ R +L WP P + ++ ++E G+ +++ + VQ + LR +PL+ G L N + LIY + K S + TS ++ + + +KR+ + P + RD P L+S + IS P NF H++HMGP Q L+DL
Sbjct: 1 MSAKVRLKK-----LEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNG---DCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALSNSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVVRQ---EKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRDKEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQGGRGAGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQLALQKEILMLKDKL---EKSKRERH-NEMEEAVGTIKDKYERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELEALRSSSL---------GSR---TLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNTAPLAHDLTFRTSSASEQETQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPTTQALALAGPKPKAHQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGA-PQVCPIPPEQSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKS-TQPGVIA---SQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTENENEKRKWVGILEGLQSILHKNRLRNQVV--HVPLEAYDSSLPLIKAILTAAIVDADRIAVGLEEGLYVIEVTRDVIVRAADCKKVHQIELAPRE--KIVILLCGRNHHVHLYPWSSLDGAEGSFDIKLPETKGC---------------------QLMATATLKRNSGT-----CLFVAVKRLILCYEIQRTKPFHRKFNEIVAPGSVQCLAVL--RDRLCVGYPSGFCLLSIQGDGQP----LNLVNPNDPSLAFLSQQSFDALCAVELESEEYLLCFSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVYSEY-GVDVFDV--RTMEWVQTIGLRRIRPLNSEG-TLNLLN--CEPPRLIYF------KSKFSGAVLNVPDTSDNSKKQMLRTRSKRRFVFKV--------------PEEERLQQRREMLRD-PELRS-KMISNPTNFNHVAHMGPGDGMQVLMDL 1607
BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Match: sp|O01583|MRCK_CAEEL (Serine/threonine-protein kinase mrck-1 OS=Caenorhabditis elegans OX=6239 GN=mrck-1 PE=2 SV=3) HSP 1 Score: 623.239 bits (1606), Expect = 0.000e+0 Identity = 487/1631 (29.86%), Postives = 806/1631 (49.42%), Query Frame = 2
Query: 74 IKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDD--VSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFD----DFNA---NHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNY---------DYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQP----------DIQVEK----QRFEEVMLQLRS--ENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQ--------LKSQVKSLSEENVEL-RSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKT---LCVDN--DGDQKAQGERQDNN--GNESWRLRKCVKAD-------KIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQL-------EKYKQDVNEKDNLIANLKSASQNLEPHVPKEIPSNPVTLSEFNSIL-----------------------SGSLDKTVVNCNQ--HVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGK--GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIEN-------SSTMLPIYVLF--ESVDNKEDCIKVIEEARSYIKKDPHY-RMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFG-TEEGLLKVTDS-------GYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLW-----ETGSPXXXXXXXXXXXXXN-----FQYI-FQTNFESMLIVEI--SFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTE-MAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGP 4591
++ ++ S P++++ E LIDSL C Y EC + EK +A+F++S+K + K + LR+ R DF+ ++VIG+GAFG+V+VVR + GEIYAMK L+K++++K+ + ACF+EERDVL + WIT LHYAFQDE LYFVMD+Y GGDMLTLLSKF D +PE + KFYIAE+V++ID +H+LGY+HRD+KPDN+LLD GHI LADFGSC+++ +G+ + AVGTPDYISPEILR+ E G G YG ECDWWSLGI ++EMLYG PFY+E +TY +IM+ + P + D VS+EA+DLI+QLIC + R G G+ DF+ HPFF IDW+ +R N P++PEVSS EDTSNF+ D DF + P + + F G HLP +GF++T + ++ S +R ++ + A L E + D + E+ K ++L ++L E +T Q + +P ++ + E + Q ++ D +L +++QK D I K+ EL Q++ +K +I+ +L + ++ +Q+ + +++D ++ EL + + EK+ +K L + +++ +I+ EK ++ EEV ++ R E D L + + N SL+ +++ + EIK LK+ + + + E++QL+ E ++L N + L+ +++ LS++ L R L E + H + + +E E L ++ EVE LK L N G R+ NN + L++ ++A+ K E+ N + D EK++ E+ + +Q + + D +I+ + + +E+ S T S N+IL SG ++ + H F P KC +CTS ++G QG+ C+ C ++CH C V + C + + G + G+GT YE +K P+ GG+R+GW+ ++ +CD KL+ +D +M D+ V+D++ +F V VS +V+HA K D+ I +++ S+ Y LF E+ + K + + E ++ +++ R F K + + + R AIID+S ++ G ++ GL + S G K +++ V +E + ++L ++ V +K R ++++ S LDG D + I V + K C VG + +PG + +A AFK SV ++ ++ RH+K + + + S+ I +L +G S +SL GS +N Q++ QT++E+ LIV + S +EYL++F G+++N R++R P++ +P + F Y PYL F+E +F + E VQ + LRS+KPL G IL+T + I+V L + +++ SI ++ S S + + +RK ++ ++ G R +S+ QIS P +F H+ HMGP
Sbjct: 17 LENIYMDGPSKKPEALSFETLIDSLICLYDECCNSTLRKEKCIAEFVESVKTVISKAKKLRLSRDDFEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDR---RWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPESMAKFYIAEMVLAIDSLHRLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMEDGRGRYGKECDWWSLGICMYEMLYGTTPFYSERLVDTYGKIMSHQDMLDFPDDEIDWVVSEEAKDLIRQLICSSDVRFGRNGLSDFQLHPFFEGIDWNTIRDSNPPYVPEVSSPEDTSNFDVDVCEDDFTPCLQETQPPRVLAAFTGNHLPFVGFSYTHGSLLSDARSLTDEIR--AIAQRCQGDAELM----EKSVDGFMVELENEK---AELVQKLKEAQTIIAQHVAENPRSEE-DRNYESTIAQLKDEIQILNKRLEDEALAQQQQKPKDEIVAES--EKKLKELKERNKQLVMEKSEIQRELDNINDHLDQVLVEKATVVQQRDDMQAELADVGDSLLTEKDSVKRLQDEAEKAKKQVADFEEKLKEIETEKIALIKKQEEVTIEARKSVETDDHLSEEVVAAKNTIASLQATNE---ERETEIKKLKQRMDEERASHTAQSEQEMKQLEAHY-ERAQKMLQDNVEQMNVENRGLRDEIEKLSQQMAALPRGGLNE-----QQLH-EIFNWVSEEKATREEMENLTRKITGEVESLKNNSPLTTSNYIQNTPSGWGSRRMNNVARKDGLDLQRQLQAEIDAKLKLKAELKNSQEQYLTSAARLDDTEKRMASLMREVAMLKQQKNIENSSDSAFSSTMGRGDLMISMNNDYEMSNSSLMRQEMISRQSTPSYENAILLHDHQVPKRVDDLRYKQKPMKTASGIFSPVSISAMERGHNFERMKIKTPTKCGHCTSILIGLDRQGLFCQSCQYACHVSCAERV-SQSCPVPEEERRPLGIDPTRGVGTAYEGLVKTPRAGGVRKGWQTAYVVVCDFKLYLYDCTVDRQ-NKMQDVKNEIRLVLDMRDPDFTVCGVSEADVIHAQKGDIPKIFRVTTTQILNSSSEYSSSSKFYTLFMAETEEEKRKWVVALSELKTLLRRSKLADRKAFLVKEVFDVTTLP-SIRVAQCCAIIDRSKIVIGFSDHGLYCIEISRQLLIPVGGEKENKQRCVETVEYDEAEQLLMMIVGPAKDRHVRIVPSAALDG-RDLKWIKVNDTKGCHLLAVGTN--NPGGRAGFFA-----------------------VAFKKSVTIFQIDRSEKRHKKWKDLAMPGTPQSIAI--FNGRLYVGFSHSFRSWSLVGVDSSPVGSGDASGAVLQHISLVNMEDTSLQFLNQQTSYEAKLIVNVPGSPDEYLLVFNMIGLYVNEMGRRSRLPEVMFPTQAKYFAYHEPYLCVFSENEVDIFNVTLAE----WVQTINLRSAKPLSGDG-ILSTC---LCNDSPIFVLLQNVLQDQDSIEVPVNLASGSTD---GRKVTRRKFTF----------------------RTIGKDDRSASERRSHIQISTPSDFMHIVHMGP 1558
BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q9W1B0|GEK_DROME (Serine/threonine-protein kinase Genghis Khan OS=Drosophila melanogaster OX=7227 GN=gek PE=1 SV=1) HSP 1 Score: 616.305 bits (1588), Expect = 0.000e+0 Identity = 495/1619 (30.57%), Postives = 799/1619 (49.35%), Query Frame = 2
Query: 122 TLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYD---DVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDFNAN-HEGPPLSSN--FKGCHLPCIGFTFTKDFIFNEMGSE-ESSVRLKSLMENIGAP--ALLNGNHNESNSD-----ALLEEVNQLKITCSQLEKQLNEC-----------RTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIK--SLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQ-VKSLSEEN----VELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKTLC------VDNDGDQKAQGERQDNNG--NESWRLRKCVKADKI---EISNLNLTLQSERRARADLEKK-------LTQQKSEICDISKQLEKYKQDVNEK--------------------------------DNLIANL--------------KSASQNLEPHVP-KEIPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGK---GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVE--FIIKISIENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKD--PHYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGLLKVTDSGYN--KIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEI------SFNEYLILFECAGIFINRNHRQTRP-DLQWPDKPTRFTYRAPYLLCFTEM-AGLFAYEITEHSCNLVQALPLRSSKPLDRSGH-ILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRK-PSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQ---LIDL 4618
+L++L+D+ Y EC + EK V+ F+K K V + LR+ R DFD +++IGRGAFG+V VV+ ++YAMK L+K+++LK+ + ACF+EERDVL + WIT LHYAFQD LY VMD+Y GGD+LTLLSKF D+LPE++ KFYI E++++I+ +H++ Y+HRDIKPDN+LLD GH+ LADFGSC++L +GT + AVGTPDYISPEILR+ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + CF +P++ VS+ ++DL+ +LIC E RLG GI DF +HP+F IDW N+R AP++PEVSS DTSNF+ DD + + P S+N F G HLP IGFTF+ + +SS ++ I +P A+L N++E+ D AL +++ LK ++L KQ NE + QR + Y ++ +L Q Q +R+KE+++D ++ N L E L+K +L++ E+ + K + + +L ++ E LSI S +I+ + +F E + ++ ++ LE +R + S L N+ + + +E +K ++ I + E L+L +++E K S EE+ R L+S LKS+ +K L E+ ELR + I+ + ++ + D++ + + L T++ E+E LK + VDN + + ++ D N L++ ++A + E+S L S ++ D +K+ ++++E+ D+ K +Y + K DN N K A +N + H KE + ++ E + ++ S K N H F TF+ P KC++CTS M+G QGV C+ C F+CH C V C K G + GIGT YE ++KVPK G I+RGW RQF+ +CD KLF +D+ +P +S + +V+D++ EF V V +V+HA KKDV F IK ++ + L +L ++ K + + E +K++ P+ IF L+N +S+ R L + II + +L GTE+GL + Y +IGE K + + ++++ Q++ ++ KQR L+LL L+ A D E I V K+C + G P ++ + +K P+N + VY +N TRH+K + LQI +L++ Y L + + L+H + + ++ + +++ ++EI +F EYL++F+ I+++ R++R ++ +P PT T+ +LL F++ +F + E VQ++ L+ S PL+ G+ +L++ N+ + L +H + L ++ N++ PS ++ + N I + + ++ IS P NF H+SHMGP Q L+DL
Sbjct: 50 SLDYLLDTFIVLYDECSNSSLRREKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDR---QWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGIDWKNIRQGPAPYVPEVSSPTDTSNFDVDDNDVRLTDSIPPSANPAFSGFHLPFIGFTFSLTSSSTLDSKKNQSSGFGDDTLDTISSPQLAILPSNNSETPVDSVQLKALNDQLAALKQEKAELSKQHNEVFERLKTQDSELQDAISQRNIAMMEYSEVTEKLSELRNQKQKLSRQVRDKEEELDGAMQKNDSLRNE-----------LRKSDKTRRELELHIEDAVIEAAKEKKLREHAEDCCRQLQMELRKGSSSVETTMPLSISSEMSSYEIERLELQFSEKLSHQQTRHNMELEALREQFSELENANLALTKELQQTQERLKYTQMESITDSAETLLELKKQHDLE--KSSWFEEKQR-LSSEVNLKSKSLKELQAEDDEIFKELRMKREAITLWERQMAEIIQWVSDEKDARGYLQA-LATKMTEELEYLKHVGTFNNNGVDNKNWRNRRSQKLDKMELLNLQSALQREIQAKNMISDELSQTRSDLISTQKEVRDYKKRYDSILHDFQKKETELRDLQKGGLEYSESFLNKSTHHGLSSAFFRDMSKNSEIIDSAESFGNESGDNFTPNFFQSGNSGMLFNYEPKYAGKNNKDHSSMKEASVSDLSREESDQLVKESQKKVPGNTAIHQFLVRTFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHTICCQKVPT-TCPVPMDQTKRPLGIDPTRGIGTAYEGYVKVPKSGVIKRGWIRQFVVVCDFKLFLYDISPDRCA--LPSVSVS--QVLDMRDPEFSVGSVRESDVIHAAKKDVPCIFKIKTALIDGGLSLNTLMLADNESEKSKWVIALGELHRILKRNSLPN-TAIFKVNEILDNT-LSL-IRNALCSVIIYPNQILLGTEDGLFYINLDQYEIARIGESKKILQLWYIEEE--QILVILCGKQRNLRLLPIRALE-ASDVEWIKVVESKNCISACTGIIRRFP---------NIVYSFIIALKRPNN----------HTQIVVYEINRTRTRHQKTCEFTIGYMAQHLQILSD-MRLVVAHQSGFTAYFLRGEATAMSLVHPENQLCA----FLNYSGVDAVRVIEILCPSGGNFGEYLLVFQTLAIYVDLQGRKSRDREIMYPAFPTYITFCDGHLLVFSDTHLDIFNTQTAE----WVQSIGLKQSLPLNNLGNVVLSSVNDTPLIVYLSNIH--------------------TKGLLQYRDGNRKGLPSIKRRFSIREINKTIKSD-------------------RRSKMISAPTNFNHISHMGPGDGIQNQRLLDL 1572
BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Match: sp|Q7TT49|MRCKB_RAT (Serine/threonine-protein kinase MRCK beta OS=Rattus norvegicus OX=10116 GN=Cdc42bpb PE=1 SV=1) HSP 1 Score: 598.971 bits (1543), Expect = 0.000e+0 Identity = 452/1530 (29.54%), Postives = 766/1530 (50.07%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSL---------MENI-----------------------------------GAPALLNGNHNESNSDALLEEVNQLK---ITCSQLEKQLNECRT------NSVQRIFS------------HPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXH--------------LSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQML-----EKMR------LKCSNLTNSLEQSDQTIFNIKEEIKSLKEIF--TNKEKNLKL-----SHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEI-SNKNMKFHFRLKTILDKEIVKTSENSE-----LLTELDREVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARA--------------DLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIANLK-------------------------SASQNLEPHVPKEIPSNPVTLS-----EFNSILSGSLDKTVVNCN------------QHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGK---GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRP-DLQW 4105
MS K+ LK+ +++ LL+ S+++E L+D L C Y EC + +K VA+F++ K ++ +++ R DF+ I+VIGRGAFG+V+VV+ K IYAMK L+K+++LK+ + ACF+EERDVL WIT LHYAFQDE YLY VMD+Y GGD+LTLLSKF D+LPE++ +FYI E+V++ID +H+L Y+HRDIKPDN+LLD GHI LADFGSC+K+ +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN E FQ P+ DVS+EA+DLI++LIC +E RLG GI+DFK H FF ++W+N+R+ AP+IP+VSS DTSNF+ DD N P + F G HLP IGFTFT + F++ GS +S ++ +L +EN G+ L ++ + L EE+ ++K ++LE+QL + T +S QR+ +++QLV E+L +Q + + +++++ + + E LN+ EL S + ++ ++ +D EE+++V + + ++ + + + LE L+ + KE++ +H L +++ P +E Q + + ++RSE ++ + E +R L+ N+ + +S+ +++E+ LK+ + +E++ ++ + ++ E+ + + +E ++ A N +L S V L+ +N +L LQ++ S K H+ + + V +++ L +++ E+E L++ + G R + W++R+ K D L L++E RA+ E KL + +++ ++ ++++ K+ + EK LK S++ + E K S V+++ + ++ S TV N H FS +F P +C +CTS M+G QG C+ C+FSCH C + C K G +++ GIGT Y+ ++KVPKP G+++GW+R + +CD KLF +D+ EG + TQ I+ +V+DL+ EF V V +V+HA ++D+ I +++ + + S + +L E+ + K + ++E ++ + K+ + + + + + +L+AAI+D + G EEGL +++T + + K VY IE + K++++ LLL G H + P +G + F + K + G Q ++A T S + + A K V Y + H K +I+ V +A ++L +G ++ S+ G P + D + ++ Q +F+++ VE+ EYL+ F G++++ R++R +L W
Sbjct: 1 MSAKVRLKK-----LEQLLLDGPWRNESSLSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKDMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNG---DCQWITALHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNIEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSMIQSNTLTKDEDVQRDLENSLQIEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSTRALGNSNRDKEIKRLNEELERMKSKMADSNRLERQLEDTVTLRQEHEDSTQRLKGLEKQYRLARQEKEELHKQLVEASERLKSQTKELKDAHQQRKRALQEFSE----LNERMAELRSQKQKVSRQLRDKEEEMEVAMQKIDSMRQDIRKSEKSRKELEARLEDAVAEASKERKLREHSESFSKQMERELETLKVKQGGRGPGATLEHQ---QEISKIRSELEKKVLFYEEELVRREASHVLEVKNVKKEVHESESHQLALQKEVLMLKDKLEKSKRERHSEMEEAIGAMKDKYERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDELQDLASKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELETLRSSSL---------GSR---TLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVHEELRKVKDTSLAFESKLKESEAKNRELLEEMQSLKKRMEEKFRADTGLKLPDFQDPIFEYFNTAPLAHDLTFRTSSASDQETQASKLDLSPSVSVATSTEQQEDAARSQQRPSTVPLPNTQALAMAGPKPKAHQFSIKSFPSPTQCSHCTSLMVGLIRQGYACEVCAFSCHVSC-KDSAPQVCPIPPEQSKRPLGVDVQRGIGTAYKGYVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKS-TQPGVIA---SQVLDLRDDEFAVSSVLASDVIHATRRDIPCIFRVTASLLGSPSKTSSLLILTENENEKRKWVGILEGLQAILHKNRLRSQVVHVAQEAYDSSLPL-IKTVLAAAIVDGDRIAVGLEEGLYVIELTRDVIVRAADCKKVYQIE------------LAPKEKLI-LLLCGRNHHVHLY-PWTSFDGAEASNFDI-KLPETKGCQ-------LIATGTLRKSSST-----CLFVAVKRLVLCYEIQRTKPFHRKFNEIVAPGHVQ--WMAMFKDRLCVGYPSGFSLLSIQGDGQP----LDLVNPADPSLAFLSQQSFDALCAVELKSEEYLLCFSHMGLYVDPQGRRSRTQELMW 1464
BLAST of Serine/threonine kinase vs. TrEMBL
Match: A0A4S2MD18 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_000895 PE=3 SV=1) HSP 1 Score: 792.341 bits (2045), Expect = 0.000e+0 Identity = 534/1556 (34.32%), Postives = 830/1556 (53.34%), Query Frame = 2
Query: 47 TLKQRHENLIKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLM--------------------ENIGAPAL---LNGNHNESNSDALLEEVNQLKITCSQLEKQLNEC-RTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNRLLNKE----RDELTSDR---LQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRS-ENDQMLEKM----RLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKTLCVDNDGDQKAQGERQ-----------DNNGNES-------------------WRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIAN-----LKSASQ---------------NLEPH-------------VPKEIP---------SNPVTLSEFNSILSGSLDKT-VVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCL-SNVLNDKCYTRKSAGKGANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVK-----EGSTGTQMPD-----------------------ISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHYRMIFTEKSCLNNLDI----SMNYRQILSAAIIDQSTLLFGTEEGLLKVTDSGYNKI---GEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRPD-LQWPDK---PTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHI 4264
+L++R L K + S P V++E+L+D++ C YECRLP K E+N A+F+ ++K V+KIES I R++F+TIR+IG GAFG+VSVVR++ G +YA+KSLHK+D+LK+ D ACFQEERDV+ +A+ KSPWI +LH+AFQD+ +LYF+MDFYNGGDMLT+LSKF+DR+PE I +FYIAE+V++I+ +H LGY+HRDIKPDN+L++S GH+VLADFGSC+KL NG AVGTPDYISPEILR+ E GHG YGVECD+WSLG+VIHE+L+GE PFY+E+ ETY QIMNFE F++P + DVS+ A DLI++LIC ++ RLG G +FK HPFF EI WD +R P+IPEV EDTSNF+ HEGPPL F+GC + CIGFTFT NE+ S +SLM E+ PA+ ++ H++ N ++ L+ V QL+ C + E ++ + +T SV + Q E L TQ + L K + L +NR + R ELT + ++L +D EE+ +V+ + +S + ++ E+ L +L L+ + + ++ + + + + I+ + + F L + E+ Q + RL + +L +++ + K+E++S+K +++ ++ +QL+ ++ + + + ++ +L EL +S I N + + LK D E V + + E+E L+ C+ + A E +N NE+ WR RK K +K+E SNL + L +E RAR E +L + ++++ +++ QL+ + + E++ ++ L+ ++Q +L PH + +P S P S ++ SGS+ + + + H F+ +F P KC CTS +LGQ +QGV+C+ C FSCH C S + + G + G G + E+ +++PK G I+RGW R +M L D++LF FDV GS G+ P S NP RVIDL+ F V +V +V+HA + ++ I+KI+++N P+++LF++ + +K I++A I+++ R I + C+ D+ ++ +QI A ++D+ +L G++EG L V D + I G+KKPV+ IE+L+ +ELQLV VIQ K R LKLLL ++G E I V + K+C+ FV G S ++ + ++CAA + SV VY + +RH ++R+ILC +V ++ I G+ L +G A+Y +W G L+ DL D+D F + Q F++ L V++ NE+L++FE GI++N + ++TR D L WP K + F + PYL FTE+ GL + IT S V +L R +PL H+
Sbjct: 7 SLEERVAELTKLYSPGSSCSEP-VVSIEYLLDTIVCLAYECRLPQLKSERNCAKFLSAVKQCVEKIESCWINRNEFETIRLIGSGAFGEVSVVRWRADGGVYALKSLHKFDMLKRSDRACFQEERDVMVKALVHKSPWIAKLHHAFQDDKFLYFLMDFYNGGDMLTMLSKFDDRIPENIARFYIAEMVLAINALHDLGYVHRDIKPDNVLIESSGHVVLADFGSCLKLGANGLVQNNTAVGTPDYISPEILRATEDGHGTYGVECDFWSLGVVIHELLFGETPFYSENLVETYSQIMNFEEHFRMPDDCPDVSENARDLIRRLICDRKRRLGRGGAHEFKEHPFFSEIRWDTIRQETPPYIPEVRCPEDTSNFDIAQTPRTHEGPPLGPMFRGCQVACIGFTFTNGSPLNELASASPVTTAQSLMDSCTVSKMITSTRPDFVESEESTEKPAVQSTMDSEHSK-NLESQLQLVEQLRSQCREYELRIQQLEKTCSVSDVAHEDNSTQDSLYSETLKTQLADLQCQLDSLNDKYEQLGVSNRKAEETIIQLRTELTEQQETNCKLLANLRDFEEENEVLCKRAADAQSALRQLDAEQQELLSDLASLRAERVAHRQYGHNTEYESSGALIPIKNDSKAFSSTPASLDNVEHGQTSSHLSAYDRLHETETHYNL--ANERLATAKQELQSMKAARQAEQREWSRERESLGQQLQSAMVDRANAL--------RELHALQANYSELEAS---ILNWERRL-YELKQWADDERVAKDKLHVFTCRVVSELEALRLACLGPEASLPAAEENMHYDYQPVCNGTNNVTNETISFGMDSPAASVTGDGTLDWRQRKSCKVNKMERSNLQVALNNEVRAREQAELRLQEVETKLKEVTDQLKMKETKIEEQERMLEAFNDQLLQVSNQASLLHMQNGVTDDVLSLSPHHVSNAEQTCRATESRRSLPLLSLDNLQHSTPAHRSSLDN--SGSIAPSQYSSTSAHDFTLDSFTGPTKCRVCTSLILGQRFQGVRCQNCGFSCHQRCRHSAPVGCPAPLISAPNPGLDGIYGFGAVLESIVQMPKSGIIKRGWTRHYMFLTDMRLFVFDVTTENSVNGSFGSLSPSNPSFPWSRYPSPSNSVNNVSCVFTSNNPTRVIDLRSPGFSVTRVRDADVIHAKRNEISRILKITLDNRLPAAPLFLLFDTSHLCDRWLKAIDDAARLIQRN--LRKI-PDAECIQLQDVCDSSALLLKQIRCACVLDEHRVLIGSDEG-LHVVDVKHGTIIRRGDKKPVFQIEALN-EELQLVVVIQEKTRRLKLLLLATIEGISS-EQIKVVDPKTCSQFVCGMS--------------------------RSNTVCLLCAAGRRSVWVYEIARVRSRHRRVREILCPDNVQAVNIVRGGDWLCVGCPSYFALYHIWSEGPAQALLRTDLVDLDPTFAFFQQNAFDAYLGVQVDDNEFLLIFENCGIYVNTSRQRTRTDNLMWPAKLISTSPFAFTWPYLYVFTEV-GLVVFNIT--SGLWVASLCGRQVRPLSSDAHL 1509
BLAST of Serine/threonine kinase vs. TrEMBL
Match: A0A4S2MD13 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_000895 PE=3 SV=1) HSP 1 Score: 792.341 bits (2045), Expect = 0.000e+0 Identity = 534/1556 (34.32%), Postives = 831/1556 (53.41%), Query Frame = 2
Query: 47 TLKQRHENLIKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLM--------------------ENIGAPAL---LNGNHNESNSDALLEEVNQLKITCSQLEKQLNEC-RTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNR----LLNKERDELTSDR---LQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRS-ENDQMLEKM----RLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKTLCVDNDGDQKAQGERQ-----------DNNGNES-------------------WRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIAN-----LKSASQ---------------NLEPH-------------VPKEIP---------SNPVTLSEFNSILSGSLDKT-VVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCL-SNVLNDKCYTRKSAGKGANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVK-----EGSTGTQMPD-----------------------ISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHYRMIFTEKSCLNNLDI----SMNYRQILSAAIIDQSTLLFGTEEGLLKVTDSGYNKI---GEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRPD-LQWPDK---PTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHI 4264
+L++R L K + S P V++E+L+D++ C YECRLP K E+N A+F+ ++K V+KIES I R++F+TIR+IG GAFG+VSVVR++ G +YA+KSLHK+D+LK+ D ACFQEERDV+ +A+ KSPWI +LH+AFQD+ +LYF+MDFYNGGDMLT+LSKF+DR+PE I +FYIAE+V++I+ +H LGY+HRDIKPDN+L++S GH+VLADFGSC+KL NG AVGTPDYISPEILR+ E GHG YGVECD+WSLG+VIHE+L+GE PFY+E+ ETY QIMNFE F++P + DVS+ A DLI++LIC ++ RLG G +FK HPFF EI WD +R P+IPEV EDTSNF+ HEGPPL F+GC + CIGFTFT NE+ S +SLM E+ PA+ ++ H++ N ++ L+ V QL+ C + E ++ + +T SV + Q E L TQ + L K + L +NR + + R ELT + ++L +D EE+ +V+ + +S + ++ E+ L +L L+ + + ++ + + + + I+ + + F L + E+ Q + RL + +L +++ + K+E++S+K +++ ++ +QL+ ++ + + + ++ +L EL +S I N + + LK D E V + + E+E L+ C+ + A E +N NE+ WR RK K +K+E SNL + L +E RAR E +L + ++++ +++ QL+ + + E++ ++ L+ ++Q +L PH + +P S P S ++ SGS+ + + + H F+ +F P KC CTS +LGQ +QGV+C+ C FSCH C S + + G + G G + E+ +++PK G I+RGW R +M L D++LF FDV GS G+ P S NP RVIDL+ F V +V +V+HA + ++ I+KI+++N P+++LF++ + +K I++A I+++ R I + C+ D+ ++ +QI A ++D+ +L G++EG L V D + I G+KKPV+ IE+L+ +ELQLV VIQ K R LKLLL ++G E I V + K+C+ FV G S ++ + ++CAA + SV VY + +RH ++R+ILC +V ++ I G+ L +G A+Y +W G L+ DL D+D F + Q F++ L V++ NE+L++FE GI++N + ++TR D L WP K + F + PYL FTE+ GL + IT S V +L R +PL H+
Sbjct: 7 SLEERVAELTKLYSPGSSCSEP-VVSIEYLLDTIVCLAYECRLPQLKSERNCAKFLSAVKQCVEKIESCWINRNEFETIRLIGSGAFGEVSVVRWRADGGVYALKSLHKFDMLKRSDRACFQEERDVMVKALVHKSPWIAKLHHAFQDDKFLYFLMDFYNGGDMLTMLSKFDDRIPENIARFYIAEMVLAINALHDLGYVHRDIKPDNVLIESSGHVVLADFGSCLKLGANGLVQNNTAVGTPDYISPEILRATEDGHGTYGVECDFWSLGVVIHELLFGETPFYSENLVETYSQIMNFEEHFRMPDDCPDVSENARDLIRRLICDRKRRLGRGGAHEFKEHPFFSEIRWDTIRQETPPYIPEVRCPEDTSNFDIAQTPRTHEGPPLGPMFRGCQVACIGFTFTNGSPLNELASASPVTTAQSLMDSCTVSKMITSTRPDFVESEESTEKPAVQSTMDSEHSK-NLESQLQLVEQLRSQCREYELRIQQLEKTCSVSDVAHEDNSTQDSLYSETLKTQLADLQCQLDSLNDKYEQLGVSNRKAEETIIQLRTELTEQQETNCKLLANLRDFEEENEVLCKRAADAQSALRQLDAEQQELLSDLASLRAERVAHRQYGHNTEYESSGALIPIKNDSKAFSSTPASLDNVEHGQTSSHLSAYDRLHETETHYNL--ANERLATAKQELQSMKAARQAEQREWSRERESLGQQLQSAMVDRANAL--------RELHALQANYSELEAS---ILNWERRL-YELKQWADDERVAKDKLHVFTCRVVSELEALRLACLGPEASLPAAEENMHYDYQPVCNGTNNVTNETISFGMDSPAASVTGDGTLDWRQRKSCKVNKMERSNLQVALNNEVRAREQAELRLQEVETKLKEVTDQLKMKETKIEEQERMLEAFNDQLLQVSNQASLLHMQNGVTDDVLSLSPHHVSNAEQTCRATESRRSLPLLSLDNLQHSTPAHRSSLDN--SGSIAPSQYSSTSAHDFTLDSFTGPTKCRVCTSLILGQRFQGVRCQNCGFSCHQRCRHSAPVGCPAPLISAPNPGLDGIYGFGAVLESIVQMPKSGIIKRGWTRHYMFLTDMRLFVFDVTTENSVNGSFGSLSPSNPSFPWSRYPSPSNSVNNVSCVFTSNNPTRVIDLRSPGFSVTRVRDADVIHAKRNEISRILKITLDNRLPAAPLFLLFDTSHLCDRWLKAIDDAARLIQRN--LRKI-PDAECIQLQDVCDSSALLLKQIRCACVLDEHRVLIGSDEG-LHVVDVKHGTIIRRGDKKPVFQIEALN-EELQLVVVIQEKTRRLKLLLLATIEGISS-EQIKVVDPKTCSQFVCGMS--------------------------RSNTVCLLCAAGRRSVWVYEIARVRSRHRRVREILCPDNVQAVNIVRGGDWLCVGCPSYFALYHIWSEGPAQALLRTDLVDLDPTFAFFQQNAFDAYLGVQVDDNEFLLIFENCGIYVNTSRQRTRTDNLMWPAKLISTSPFAFTWPYLYVFTEV-GLVVFNIT--SGLWVASLCGRQVRPLSSDAHL 1509
BLAST of Serine/threonine kinase vs. TrEMBL
Match: A0A504YH18 (CDC42BPB protein OS=Fasciola gigantica OX=46835 GN=FGIG_05120 PE=3 SV=1) HSP 1 Score: 775.778 bits (2002), Expect = 0.000e+0 Identity = 528/1546 (34.15%), Postives = 812/1546 (52.52%), Query Frame = 2
Query: 65 ENLIKEFLLNYKSSVP----DSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMG-----SEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECR-----TNSVQRIFSHPVYQQLVT---DKEKLLTQC-----QNYDY------------SLREKEQKMD----DLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVM-----------TENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVE-KQRFEEVMLQLRSENDQM----LEKMRLKCSNLTNSLE-QSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKF-----HFRLKTILDKEI-------VKTSENSELLTELDREVEL------LKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIANLK-------SASQ---------NLEPHV--------------------------------PKEIPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGKGANLKN--GIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVK------------EGS-------------------TGTQMPD----ISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHYRMIFTEKSCLNNLDIS----MNYRQILSAAIIDQSTLLFGTEEGLLKVTDSGYNKI---GEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRPD-LQWPDK---PTRFTYRAPYLLCFTEMAGLFAYEIT 4192
E IKE + Y S P SV++E+L+D++ C YECRLP H+ E+N +F +S+K V++IE I R +F+TIR+IG GAFG+VSVVR+K G+IYA+KSLHK+D+LK+ D ACFQEERDV+ +AM KSPWI +LH+AFQDE +LYF+MDFYNGGDMLT+LSKF+D++PE+I +FYIAE+V++ID +H+LGY+HRDIKPDN+LL+ GHIVLADFGSC+KL NG AVGTPDYISPEILR+ E HG YGVECD+WSLG+V++EML+GE PFY+E+ ETY IMNFE F IP + +VS+ A DL+ +LIC ++ RLG G+ DFK HPFF++IDWD++R P+ PEV S +DTSNF+ + NHEGPPL F+GC + CIGFTFT NE+G S+ + + + +I P + + S +++ L E L+ C + E ++ + +NS + + + + D E L T+C QN DY +E QK+ D E N L K + S +Q+ ++ D+ DL + T + N L+S++ A + + ++ + +N D Q E +R ++ L+ D++ E LK + T E D+TI + L+ T++ LK E+ L+ E +S I +S++ LS+ + R++ ++ ++ RL ++ + + V T+ SE T + V+ +LC+D+ GE WRLRK K +K+E SNL + L +E R R E + + ++++ ++ Q++ + E++ +I +LK +A+Q NL+ + P P P T E +S SG + + + H F+ +TF P KC CTS MLG +QGV+C++C F CH C C + G + G GT+ E +++PK GGI+RGW R ++ L D++LF +D+ GS G+ M +S +P R++D++ F V +VS +V+HA + D+ I+K+ ++N +++LF++ + + ++ ++++ +++ H R I + CL ++ + +QIL A ++D+ +L G ++G L V D + I G+KKPV+ +E+L ++LQ+V +IQ KQR LKLLL G ++G ++PI + K+C+ FV G +S GN +I ++CAA + SV VY + RH +LR+I C V S+Q A G+ L IG A+Y+LW L+ DL D+D + + Q + L V++ +E+L++FE G+++N + ++TRPD L WP K F + PYL FTE AGL YE+T
Sbjct: 9 EERIKELVSLYTESSPFFDHGSVSIEYLLDTIVCLSYECRLPQHRSERNCLKFSESVKPYVERIERCWISRDEFETIRLIGSGAFGEVSVVRWKNDGQIYALKSLHKFDMLKRSDRACFQEERDVMVKAMVKKSPWIAKLHHAFQDEKFLYFLMDFYNGGDMLTMLSKFDDKIPEDIARFYIAEIVLAIDSLHQLGYVHRDIKPDNVLLECSGHIVLADFGSCLKLSENGLVKNSTAVGTPDYISPEILRATEDDHGTYGVECDFWSLGVVMYEMLFGETPFYSENLIETYGHIMNFEEHFTIPDDGTEVSEPARDLMCRLICDRKRRLGRNGLSDFKTHPFFKKIDWDHIREQTPPYKPEVKSPDDTSNFDIEQSTRNHEGPPLGPIFRGCQVACIGFTFTNGSPLNELGTRHTKSDHNPDGTVTELASIKMPTTSGPDVSTSEAESSLIE---LQARCREYELRIQQLESSLPISNSTDSVITTALPNSVAAVEKDLEALSTRCQQLEAQNGDYFESITTLKAELLEQQEANQKLSAELRDFEEENESLCKRASDAQSTIMQLETERTDLLSDLSRLRAELAAHRQYSTTSSNLLRSSDFADSELLHNSSSVTGRNEQTKGFSSTPALLDNGAENHDT-DTQFELYERIRDLETTLKVTTDRLNCNKQEFHALKAARQTEQKEWDQDRTILE-----QRLQNALTDQSSTLK-----ELNDLQAKYTELESSI----GNWESKLYELSQWADDERAAKDKLHAFTVRVVSELEALRLASLGPEGMMTNHDNNVTTTSTSEYQTAWNGAVQPSASTNETASLCMDSPA-MSMTGE-----STLDWRLRKSSKMNKMERSNLQVALNNEVRVREQAELRSQEAEAKLKELFDQVKMKDMKIQEQERIIESLKDQLLEASAANQSRLLRINNGNLDDSICLNQRVSKLDANGSLNETTERPLQAMELSALHPTSTPLAPHTSWEPSS-RSGQTNHST---SAHKFTLTTFTDPTKCHACTSLMLGLRWQGVRCQDCGFQCHQRC-RQTATSACPAPSATLLGNSFDGGCGFGTVLEGVVQMPKAGGIKRGWTRHYLFLSDMRLFVYDITVDPSSHTCDNNVNGSIHSVSQTTSLFPWSRLHSPNGSMMSVSSTFLSNSPNRIVDMRSPGFSVSRVSDMDVIHAKRNDIPKILKVILDNRLPSACLFLLFDNQNLADRWLRAMDDSARLVQR--HMRKI-PDDECLRMQEVCDPGFLMVKQILCACVLDEDRILLGADDG-LHVADIKHGTIVRRGDKKPVFQVEAL-AEDLQVVVIIQEKQRRLKLLLLGTIEGMQ-FDPIKLSEPKTCSQFVCG---MSRGN-----------------------KISLLCAAGRRSVWVYEIARVRGRHRRLREITCPDMVQSIQFARGGDWLCIGCPSFFALYNLWTDAPAQALLRTDLVDLDPSLSFFQQVACNAHLSVQVDDDEFLLVFESCGVYVNTHRQRTRPDHLMWPAKLLAGNPFGFMWPYLYVFTE-AGLVVYEVT 1492
BLAST of Serine/threonine kinase vs. TrEMBL
Match: A0A3Q0KR06 (Serine/threonine kinase OS=Schistosoma mansoni OX=6183 PE=3 SV=1) HSP 1 Score: 759.599 bits (1960), Expect = 0.000e+0 Identity = 556/1754 (31.70%), Postives = 843/1754 (48.06%), Query Frame = 2
Query: 74 IKEFLLNYKSSVP----DSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLME------------NIGAPALLNGNHNESNSD---------ALLEEVNQLKITCSQLEKQLNEC-------RTNSVQRIFSHPVYQQLVTDKEK-------------LLTQCQNYDYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQ--LRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDN------EIEQLKISVAEEQSRILASNTQLKSQVK-SLSEENVELRSSLQEISNKNMKFH----------FRLKTILDKEIVKTSENSELLTELDREVELLKTLCVDNDGDQKA------QGERQDNNGNE----------------SWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIANLKSA--------------------SQNLEPHVPKE---------IP----SNPVTLSEFNSILSGSLDKTVVNCNQ---HVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNV------LNDKCYTRKSAGKGANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKE--------GSTGTQMPDI--------------------------SRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHYRMIFT--EKSCLNNLDISMN-----YRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRPD-LQWPDK---PTRFTYRAPYLLCFTEMAGLFAYEI-------TEHSCNLVQALPLRSSKPL-----------------------DRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSN--------------TLSIFKFLNKRKPS-----YNKQEDSFD-TNDAISPNPAGN------------STKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVP-CQLIDL 4618
I E + Y S P +S+++E+L+D++ C YEC+LP HK+E+N +F ++K VDKIES I +S+F+TIR+IG GAFG VSVV++K G+IYA+KSLHKYD+LK+ D ACFQEERDV+ +AM KS W+ +LH+ FQDE +LYF+MDFYNGGDMLT+LSKF+D++PE I +FY++E+V++ID +H+LGY+HRDIKPDN+LL S GHIVLADFGSC+KL NG AVGTPDYISPEILR++E GHG YGVECD+WSLG+V++EML+GE PFY+E+ ETY IMNFE F IPT+ +S+ A DLI+ LIC ++ R G GID+ K H FF IDW+++ P+IPEV+S +DTSNF+ + + NHEGPPL F+GC + CIGFTFT + NE+G + K +E +I P+ +G + SN+ AL+E + LK C E Q+ E R + ++ P + D K + Q + L+E E + + T LL E E R ++ + Q EE EN K + A + L + L + E H + D+ + E L+ +++ N + +NL N + S N L+E E LK +N E + K+ EQ + L+ ++K S+ ++ V L + L + N + F L +D E + L E++ L+ + D +Q Q + NN N WR RK K +K+E + + L +E +AR E L + ++ + ++ Q+ + + E+D +I +L S + N P E +P S+P T + + + +LD + + H F+ TF +P KC C S +LGQ +QGV+C++C CHH C +V LN C G G +E+ +K+PK GGI+RGW + + L D +LFF+DV G +G + S +P R++DL+ + F V V+ +V+HA ++D+ I+K+ +++ P+++LFES E K+I++ ++ R I T E CL D+S++ +QI A+++D+ L GT+EGL + + + +IG +KPVY +E+L +ELQL IQ KQR LKL+L G +G + +PI + K CT F S N+ + ++C A S+ ++ + RH++L++I C V S+ G+ + +G + A++S+W G +L+ DL D+D + + + E+ V++ +E+L+ FE G+++N N ++TRPD L WP K T ++ PYL FTE AGL + T SC VQ L + + L +G + T + ++ DL+ I + +T D S SIF + + S Y+ EDS T+ ISP N S +ST T + + IS P +FRH+SHMGP + L+DL
Sbjct: 8 INELVSLYTKSSPLLEDNSLSVEYLLDTIVCLSYECKLPQHKNERNCIKFYNAVKKYVDKIESCWISKSEFETIRLIGSGAFGDVSVVKWKNDGKIYALKSLHKYDMLKRSDRACFQEERDVMVKAMVSKSLWLAKLHHTFQDEKFLYFLMDFYNGGDMLTMLSKFDDKIPENIVQFYVSEMVLAIDSLHQLGYVHRDIKPDNVLLQSSGHIVLADFGSCLKLGENGLVKNNTAVGTPDYISPEILRASEDGHGTYGVECDYWSLGVVMYEMLFGETPFYSENLIETYSHIMNFEKHFTIPTDCVKISESACDLIRHLICDRKRRFGRNGIDELKGHAFFNGIDWEHIHEQIPPYIPEVTSPDDTSNFDIEQSSRNHEGPPLGPIFRGCQVACIGFTFTNNSPLNELGPTHYRMTSKDKLECPEEISKPEGSDDISPPSDDSGILDPSNASKFSSGTREPALIELIKALKTKCENYEMQITELKDTLSCYRESKGDQVSVKPELDPITIDLGKQDVSSGDSSTVNTITRQVEILSQKLKESEAQNQLISATVDLLKNELSEQHEIREKLQSEVQAFEE------ENETLCKRASDAQLAIRLLESEHSELLSEIARLRGELASHREYDNRTALNDVHDLLHKNESRSLENGVKNHNISISSSSSSSSTNLVNGTQHSH---INNHSSDSDLRERLYESETKLKRVMENLIAVRHEAQSFKLGWESEQKEWMKERELLEEKIKISVDQKTVALENELTTLKENNAELENNIGNWERHLFELNQWVDDEREAKEKLHNFTMRLVSELDTLRASGLVQDYNQNGVCPNGYQSSWRANNVNSLAYDSPAQSVIVDSTLDWRQRKSTKLNKMERWSHEVALNNEVKAREQAELLLQEVEARLKEMYDQINQKDLKIKEQDRIIEHLNSQLLEASNQARLCRMNNDSVNDAANFMPKATSEKNAMDNRRSLPSLDISSPYTSTPGQNSWT-TLDASGTSQTSTLTHKFTFVTFLQPTKCHVCGSLILGQKWQGVQCQDCQLKCHHRCRMSVHIVCTALNSNCIDGSP---------GFGADFESDVKMPKLGGIKRGWMKYRVFLSDKRLFFYDVVSESSNIAALGGSGNSLSPTFQNFHLSNSHNVSLSSLNTSTNSMFQSNSPSRIVDLRSSGFSVSYVTASDVIHAKQQDIPKILKVVVDDYLPSAPLFLLFESSALCECWFKLIQDVLKLVQ-----RHISTDNESQCLQVRDVSVSSVSVILKQINCASVLDEYRFLAGTDEGLYIVDIRQNINTRIGARKPVYQVEAL-AEELQLAVAIQGKQRFLKLILVGSFEGM-NLKPIKITEPKLCTRFTCSMS--------------------------RNNTVCLICVASNRSLFIFEIARVQGRHKRLKEISCPYIVQSINFVRDGDWICVGSSNYFAMFSIWTDGPAQVLLRGDLIDLDSSLAFFQHSPSEAHCAVQLGNDEFLLAFENCGVYMNSNRKKTRPDNLMWPAKLISGTAVSFSYPYLYVFTE-AGLVVFNAVTSCWVSTLSSCR-VQPLSMDAHLCLAHLSSASVSNSSSRKSAIGSIIDSSTGSVATPSPPYVSPNDLVSSQQQQQLLRLIHLPQTSDSKEMSKQQVSALRSRRLQMPQFSIFGVTGRMRKSSRFNLYSLVEDSLSGTSHGISPERVRNFRSQSQHRTPQSSVQSTVSLNPTSGTSRISNLISGPSDFRHISHMGPQITGAPLLDL 1707
BLAST of Serine/threonine kinase vs. TrEMBL
Match: A0A074ZJE8 (Kinase domain protein OS=Opisthorchis viverrini OX=6198 GN=T265_08652 PE=4 SV=1) HSP 1 Score: 731.095 bits (1886), Expect = 0.000e+0 Identity = 515/1555 (33.12%), Postives = 807/1555 (51.90%), Query Frame = 2
Query: 35 SIKLTLKQRHENLIKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDFNANHEGPPLSSNFKGCHLPCIG-------------FTFTKDFIFNEMGSEESSVRLKSLMEN---IGAPAL---LNGNHNESNSDALLEEVNQLKITCSQLEKQLNEC-RTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNRLLNKE----RDELTSDR---LQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRS-ENDQMLEKM----RLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKTLCVDNDGDQKAQGERQ------------------------------DNNGNESWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNL----------IANLKSASQ----------NLEPH-------------VPKEIP---------SNPVTLSEFNSILSGSLDKTV-VNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGKGANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVK-----EGSTGTQMPD-----------------------ISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHYRMIFTEKSCLNNLDI----SMNYRQILSAAIIDQSTLLFGTEEGLLKVTDSGYNKI---GEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRPD-LQWPDK---PTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHI 4264
S L++R L K + S P V++E+L+D++ C YECRLP K E+N A+F+ ++K V KIES I R++F+TIR+IG GAFG+VSVVR+K G +YA+KSLHK+D+LK+ D ACFQEERDV+ +A+ KSPWI +LH+AFQD+ +LYF+MDFYNGGDMLT+LSKF+DR+PE I +FYIAE+V++I+ +H LGY+HRDIKPDN+L++S GH+VLADFGSC+KL NG AVGTPDYISPEILR+ E GHG YGVECD+WSLG+VIHE+L+GE PFY+E+ ETY QIMNFE F +P + DVS+ A DLI++LIC ++ RLG G +FK HPFF EI WD +R P EDTSNF+ HEGPPL F+GC + CIG FT D + M S+ ++ +E+ PA+ ++ H++ ++ L+ V QL+ C + E ++ + +T SV + Q E L TQ + L K + L ++R+ + R ELT + ++L +D EE+ +V+ + +S + ++ E+ L +L L+ + + ++ + + + + I+ + + F L + E+ Q ++ RL+ + +L +++ + K+E++S+K +++ ++ +QL+ ++ + + + ++ +L EL +S I N + + LK D E V + + E+E L+ C+ + A E +G WR RK K +K+E SNL + L +E RAR E +L + ++++ +++ QL+ + + E++ + ++N S S +L PH + +P S P S ++ SGS+ + + + H F+ +F P KC C+S +LGQ +QGV+C+ C FSCH C +V +PK G I+RGW R +M L D++LF FDV GS G+ P S NP RV+DL+ F V +V +V+HA + ++ I+KI+++N P+++LF++ + +K I++A I+++ R I + C+ D+ ++ +QI A ++D+ +L G++EGL V D + I G+KKPV+ IE+L++ ELQLV VIQ K R LKLLL ++G E I V + K+C+ FV G S ++ + ++CAA + SV VY + +RH ++R+IL +V ++ I G L +G A+Y +W G L+ DL D+D F + Q F++ + +++ NE+L++FE GI++N + ++TR D L WP K + F + PYL FTE+ GL + IT S V +L R +PL H+
Sbjct: 3 SAPRALEERVAELTKLYSPGSLCSEP-VVSIEYLLDTIVCLAYECRLPQLKSERNCAKFLNAVKECVAKIESCWINRNEFETIRLIGSGAFGEVSVVRWKADGGVYALKSLHKFDMLKRSDRACFQEERDVMVKALVHKSPWIAKLHHAFQDDKFLYFLMDFYNGGDMLTMLSKFDDRIPENIARFYIAEMVLAINALHDLGYVHRDIKPDNVLIESSGHVVLADFGSCLKLGANGLVQNNTAVGTPDYISPEILRATEDGHGTYGVECDFWSLGVVIHELLFGETPFYSENLVETYSQIMNFEEHFHMPDDCPDVSENARDLIRRLICDRKRRLGRGGPHEFKEHPFFNEIRWDTIRQVRCP--------EDTSNFDIAQTPRTHEGPPLGPMFRGCQVACIGFTFTNGSPLNELAFTGPLDTAQSTMDSKMTTSTRPDFVESEESTEKPAVQSTIDIKHSK-RLESQLQLVEQLRSQCREYELRIQQLEKTCSVSDVTHEDNSTQDSLYSETLKTQLSDLQCQLDSLNDKYEQLGVSSRIAEETIIQLRTELTEQQETNCKLLANLRDFEEENEVLCKRAADAQSALRQLDAEQQELLSDLASLRAERVAHRQYGHNTDYESSGALIPIKNDSKAFSSTPASLDNVEHGQTGSELSAYDRLRETETHYNL--ANERLATAKQELQSMKAARQAEQREWSRERESLGQQLQNAMVDRANAL--------RELHALQANYSELEAS---ILNWERRL-YELKQWADDERVAKDKLHVFTCRVVSELEALRLACLGPEASLPAAEENMHYDYQPVCNGTNNVTNETVSFGMDSPAASITGDGTLDWRQRKSSKVNKMERSNLQVALNNEVRAREQAELRLQEVETKLKEVTDQLKLKETKIEEQERMLEAFNDQLLQVSNQASLSHVQNGVADDALSLSPHHVLNAEQTCRGTESRRSLPLLSLDNLQHSTPAHRSSLDN--SGSIAPSQHSSTSAHDFTLDSFTGPTKCRVCSSLILGQRFQGVRCQNCGFSCHQRCRHSV-----------------------------PMPKGGIIKRGWTRHYMFLTDMRLFVFDVTTENSVNGSFGSLSPSNPSFPWSRYPSPSNSVNNVSCVFTSNNPTRVVDLRSPGFSVTRVRDADVIHAKRNEIPRILKITLDNRLPAAPLFLLFDTSHLCDRWLKAIDDAARLIQRN--LRKI-PDAECIQLQDVCDSSALLLKQIRCACVLDEHRVLIGSDEGL-HVVDVKHGTIIRRGDKKPVFQIEALNE-ELQLVVVIQEKTRRLKLLLLATIEGISS-EQIKVADPKTCSQFVCGMS--------------------------RSNTVCLLCAAGRRSVWVYEIARVRSRHRRVREILFPDNVQAVSIVRGGNWLCVGCPSYFALYHIWSEGPAQALLRTDLVDLDPTFAFFQQNAFDAYMGIQVDDNEFLLIFENCGIYVNTSRQRTRTDNLMWPAKLISTSPFAFTWPYLYVFTEV-GLVVFNIT--SGLWVASLCGRQVRPLSSDAHL 1467
BLAST of Serine/threonine kinase vs. Ensembl Cavefish
Match: cdc42bpaa (CDC42 binding protein kinase alpha (DMPK-like) a [Source:ZFIN;Acc:ZDB-GENE-120727-12]) HSP 1 Score: 672.929 bits (1735), Expect = 0.000e+0 Identity = 501/1604 (31.23%), Postives = 801/1604 (49.94%), Query Frame = 2
Query: 122 TLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD--FNANHEGPPLS-SNFKGCHLPCIGFTFTKDFIFNE-----------------------MGSEESSVRLKSL-----------------MENIGAP-ALLNGNHN-ESNSDALLEEVNQLK---ITCSQLEKQLNECRT------NSVQRIFS------------HPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQ-VEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLE--------QSDQTIFNIKEEIKSL--------KEIFTNKEKNLKLSHDNEIEQLKISV----AEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILD-KEIVKTSEN--SELLTELDREVELLKTL-CVDNDGDQKAQGERQDNNGNES----WRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIANLKSASQNLEPHVPKEIPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGKGA---NLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIENSST----MLPIYVLFESVDNKEDCIKVIEEARSYIKKDP-HYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
++E L+D L C + EC + EKN+A+F++ K K++ +R+ R DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL S WIT LHYAFQD+ +LY VMD+Y GGD+LTLLSKF DRLPE++++FY+AE+V++ID VH+L Y+HRDIKPDN+LLD GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ P + +VS+ A+DLI++LIC +E RLG GI DFK HPFF IDWDN+R+ +AP+IPEVSS DTSNF+ +D ++ PP S + F G HLP +GFT+T + + + +E R++ L ++N+ P A +G+ N E L EE+ L+ QLE+ L + T S + I S +++L+ EKL Q + + +++ M + E ++++ +L S + ++ ++ +D EE++ + + L+ + R + +E + ++ + KEK+ + Q + +++ V++++ SE Q L K+R T E Q + N+++E++ KE+ K+K K +++ E+ + E+ RIL L + K LS E L +S +++S N + ++ + D KE V E +E++ + E + L + ++ +G R + G S W++R+ K D L L +E RA+ ++ +L + K+ S + K +EK N NL+ L+ + S +LS F+S+ H F +FN P KC+ CTS M+G QG C+ C+FSCH C ++ C + KG + + GIGT+YE ++VPKP G+++GW++ +CD KLF +D+ EG +S +VID++ +F V V +V+HA +KD+ I +++ S I VL ES K + V+ E +KK+ R ++ K ++ + Q SAAIID + G EEGL + VT K+G+ K ++ I+ + + QL+AVI + R ++L LD D + + K C T V G + + + +C A K V Y LN TRH +L+++ V + + G++L +G Y+L G P L D +I Q +++ VEIS E L+ F G++++ R++R +L WP PT Y APYL ++E A + +++ ++ +Q +PL+ PL+ G + ++ + LIY +A +++ + +T D +S + +KR+ S+ P + RD P ++ N+ IS P NF H+ HMGP Q++
Sbjct: 27 SVEALLDVLVCLFDECNNSPLRREKNIAEFLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKVKNSDKVFAMKILNKWEMLKRAETACFREERDVLVNG---DSQWITTLHYAFQDDNFLYLVMDYYVGGDLLTLLSKFEDRLPEDMSRFYLAEMVLAIDSVHQLHYVHRDIKPDNILLDVNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPVQITEVSENAKDLIRRLICSREHRLGQNGIHDFKQHPFFTGIDWDNIRNCDAPYIPEVSSPSDTSNFDVEDDCLKSSETMPPPSIAAFSGHHLPFVGFTYTSHILSDRGCLRESTAPVPMDVCVQRSLEESLATEAYERRIRRLEQEKLELSRKLQESTKTVQNLQYPSAEGSGSANREFEIRGLKEEIETLRKQIADSGQLEQHLEQASTAHRDFEESTKHIRSLEKQLKSIKQEKEDTHKELLQSGEKLKAQAKELKEADSQRKLAMHEFSE----MSEKMTDLRSQKQRLSRQLRDKEEEMDAVNQKLEALRLEIRKAERARKEMETQAEERAAEAQKEKKLRERSEQYSRQLEEELEGVKQKQVGRSPAAGASEQHQELSKLRADLEKKTLFYEEELSRRDVQHANELKNLRKELRDAEAQQVSLKKEVMMLKDKLDKTRRESQTEREEFETDYKQKYERERIL-----LTEENKKLSSELDNLTASYEKLSCSNKQLEEEMRELADKKESVAHWEAQITEIIQWVSDEKDARGYLQALATKMTEELEGLRNTSLGARSTDMPWKMRRLAKLDMSARLELQSALDAEIRAKQTIQDELNKVKA-----SNMATECKLQESEKKN--QNLQGEIDGLKRDMDDLRTSRGTSLS-FHSLPKA-----------HQFVVKSFNTPTKCNQCTSLMVGLIRQGCTCEVCNFSCHVTC-ADKAPAVCPIPQDQMKGPLGIDPQKGIGTVYEGQVRVPKPAGVKKGWQKAHAVVCDFKLFLYDLAEGKAAQPSVVVS----QVIDMRDEDFSVSSVLASDVIHANRKDIPCIFRVTASQLSASGNKKCSILVLAESDQEKNKWVTVLNELHRLLKKNKLKERFVYVPKEAYDSTLPLIKTTQ--SAAIIDHERIALGNEEGLYVIHVTKDEIIKVGDSKKIHHIDLIPSE--QLLAVISGRNRHVRLFPMAALDD-RDTDFYKLPETKGCQTLVSG--------------------------TIRHGALTCLCVAMKRQVICYELNKSKTRHRRLKELQVPGVVQWMYL--QGDKLCVGYQAGFLRYNLQGDGPP----ANLLHPEDHTLAFIGQLGLDALCAVEISSKELLLCFSSIGVYVDCQGRRSRQQELMWPAVPTACCYNAPYLSVYSETA-VDVFDV--NTMEWIQTIPLKKVHPLNTDGSLNLLG---LETVRLIYFKNKTAEGDELVVPETSD---NSRKQMVRSMTSKRRFSFRV--------------PEEERLQQRREMLRD-PEMR-NKLISNPTNFNHVVHMGPGDGIQIL 1532
BLAST of Serine/threonine kinase vs. Ensembl Cavefish
Match: cdc42bpb (CDC42 binding protein kinase beta (DMPK-like) [Source:ZFIN;Acc:ZDB-GENE-030131-3647]) HSP 1 Score: 624.394 bits (1609), Expect = 0.000e+0 Identity = 480/1601 (29.98%), Postives = 778/1601 (48.59%), Query Frame = 2
Query: 242 IESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD--FNANHEGPPLS-SNFKGCHLPCIGFTFTKDFIFNEMG------------------SEESSVRLKS------------------LMENIGAPALLNGNHNESNS-------DALLEEVNQLKITCS---QLEKQLNECRT-------NSVQ-----------RIFSHPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKM-----------------RLKC-----SNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQ-------VKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKTLC--VDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARA--------------DLEKKLTQQKSEICDISKQLEKYKQDVNE--------------KDNLIA--NLKSASQNLEPHVPKEIPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGK---GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIENSST---MLPIYVLFESVDNKEDCIKVIEEARSYIKKDP-HYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRP-DLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSS--SNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQ-LIDL 4618
++ +R+ R DF+ ++VIGRGAFG+V+VV+ K +YAMK L+K+++LK+ + ACF+EERDVL WIT LHYAFQD+ YLY VMD+Y GGD+LTLLSKF DRLPE+++KFY+AE+V++I +H+ Y+HRDIKPDN+LLD GHI LADFGSC+++ +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN E FQ P+ DVS++A+DLI++LIC +E RLG GI +FK H FF IDW+N+RS AP+IP+VSS DTSNF+ DD PP+S + F G HLP +GFT+T + F++ G SE+ ++L++ L E+ A L G+ + + L EE+++LK + +LE QL E T +S + R +++QLV E+L +Q + + ++++ M + E LN+ EL S + ++ ++ +D EE++ V+ + + ++ + + + LE +L+ + + KE++ +H + Q + +++ K R +E Q L K+ R C NL L S+ ++ +E+ LK+ ++ + D + LK E++ + N +L S+ V L+ +N +L LQ++++K +++ E + +E + +++ L+ L + + + + + W++R+ K D L L +E RA+ E KL S D+ +QLE K+D+ E +D++ N + +L V P L F + H S TF+ P +C +CTS M+G QG C+ CSF CH C N C K G +++ GIGT Y+ F+++PKP G+++GW+R + +CD KLF ++V EG + TQ ++ +V+DL+ EF V V +V+HA +KDV I +++ S+ + + VL ES K + ++E +S + K+ R++ +N ++ + LSAAI+D+ + GTEEGL +++T + + K V+ I+ + ++ ++V ++ + R + L G L+GA + + K C G + PG P+ + AA K V Y + H K+ ++ V L + E+L +G A+ +L SP + D + ++ Q +++ +E+ NE L+ F GI+++ R++R +L WP P + + YL +++ G+ +++ H+ VQ + LR +PL+ G + E + LIY SA + ++I +T D + T S KFL K P + RD P ++S + IS P NF H++HMGP Q L+DL
Sbjct: 2 VKEMRLHRDDFEMLKVIGRGAFGEVAVVKMKNTERVYAMKILNKWEMLKRAETACFREERDVLVNG---DCQWITTLHYAFQDDNYLYLVMDYYVGGDLLTLLSKFEDRLPEDMSKFYVAEMVLAIHSIHQQHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMMQDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHITDVSEDAKDLIQRLICSRERRLGQNGIQEFKKHAFFTGIDWENIRSTEAPYIPDVSSPSDTSNFDVDDDVLKNPDIAPPMSHTGFTGQHLPFVGFTYTTESCFSDRGRLRLAALADGGLGEGLRSSEDGGLQLEAFERRIRSLEQEKQELNRKLQESTQAAQSLYGSGRGTGTLGRDKEIKKLNEEIDRLKKKLADSDRLEHQLEEAVTLRQDYESSSTKLKALDKQVKALRQEKEDIHKQLVESLERLKSQTKELKDAHQQRKLAMQEFSE----LNERMAELRSQKQRLSRQLRDKEEEMDVVMQKIDAMRQDFRKTEKARKELEAQLEDARAEASKERKLREHSEVYSKQLEGELETLKVRGSGRASGASAETQQELTKVKSELDKKVLFYEEELVRREACHSTELKNLRKELHDSESQQLSLHKELLVLKDKLEKAKRERQTEMDEAVGTLKDKYERERNLLTEENRKLTSETDRLCTFVDKLTAQNRQLEDELQDLASKK-------ESVAHWE-AQIAEIIQWVSDEKDARGYLQALASKMTEELESLRSSSLGSRHLDPLWKVRRSQKLDMSARLELQSALDAEIRAKQLVQEELRKVKAANISFESKLKDADSRNRDLEEQLEGMKKDLEESRSRTDRGLKLPDFQDSIFEYFNTSPLAHDLTFRVSVHHGEYPSILKHFGCLFP--------QPKAHQLSIKTFSSPTQCTHCTSLMVGLIRQGYACEVCSFICHVSCKDNA-PQVCPIPPEQAKRPLGIDVQRGIGTAYKGFVRIPKPTGVKKGWQRAYAVVCDCKLFLYEVPEGKS-TQPVVVA---SQVLDLRDEEFSVSSVLASDVIHATRKDVPCIFRVTSSTLSSPVRAVSLLVLAESEAEKRKWVGILEGLQSILAKNRLKNRVVHVLHEAYDNSLPAI--KTTLSAAIVDRERIALGTEEGLFVVEITRDIIVRAADCKKVHQIDLIPKE--KMVVLLCGRNRHVHLHPWGALEGAEAAFDVKLTETKGCQALTTG--VLRPGG-------------------PA-----CLLAAIKRQVLCYEITRAKPHHRKMWEVQAPGVVQWLGMV--RERLCVGYPSGFALLALQGESSP----VSLVSPGDPSLAFLAQQPLDALHAMEVGANELLLCFSQLGIYVDAQGRRSRTQELMWPATPLACSSNSTYLTVYSDY-GVDVFDV--HTTEWVQTISLRKIRPLNVEGSLNLLGTEQPR---LIYFSNNSAGYD-LAIPETSDNSKKLMVRTRSKRKFLFK--------------------VPEEERIQQRREMLRD-PEMRS-KLISNPTNFNHVAHMGPGDGMQVLMDL 1509
BLAST of Serine/threonine kinase vs. Ensembl Cavefish
Match: cdc42bpb (CDC42 binding protein kinase beta (DMPK-like) [Source:ZFIN;Acc:ZDB-GENE-030131-3647]) HSP 1 Score: 616.69 bits (1589), Expect = 0.000e+0 Identity = 490/1630 (30.06%), Postives = 793/1630 (48.65%), Query Frame = 2
Query: 251 LRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD--FNANHEGPPLS-SNFKGCHLPCIGFTFTKDFIFNEMG------------------SEESSVRLKS------------------LMENIGAPALLNGNHNESNS-------DALLEEVNQLKITCS---QLEKQLNECRT-------NSVQ-----------RIFSHPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEK---------QRFEEVMLQLRSENDQML----EKM--RLKC-----SNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQ-------VKSLSEENVELRSSLQEI-SNKNMKFHFRLKTILDKEIVKTSENSE--LLTELDREVELLKTLCVDNDGDQKAQGERQDNNGNES------------WRLRKCVKADKIEISNLNLTLQSERRARA--------------DLEKKLTQQKSEICDISKQLEKYKQDVNE--------------KDNLIA--NLKSASQNL--------------------EPHVPKEIPSNPVTLSEF--NSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGK--GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIENSST---MLPIYVLFESVDNKEDCIKVIEEARSYIKKDP-HYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRP-DLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSS--SNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQ-LIDL 4618
+R+ R DF+ ++VIGRGAFG+V+VV+ K +YAMK L+K+++LK+ + ACF+EERDVL WIT LHYAFQD+ YLY VMD+Y GGD+LTLLSKF DRLPE+++KFY+AE+V++I +H+ Y+HRDIKPDN+LLD GHI LADFGSC+++ +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN E FQ P+ DVS++A+DLI++LIC +E RLG GI +FK H FF IDW+N+RS AP+IP+VSS DTSNF+ DD PP+S + F G HLP +GFT+T + F++ G SE+ ++L++ L E+ A L G+ + + L EE+++LK + +LE QL E T +S + R +++QLV E+L +Q + + ++++ M + E LN+ EL S + ++ ++ +D EE++ V+ + + ++ + + + LE +L+ + + KE++ +H + Q + +++ K ++ + +++SE D+ + E++ R C NL L S+ ++ +E+ LK+ ++ + D + LK E++ + N +L S+ V L+ +N +L LQ++ S K H+ + + V +++ L + E L++L + G + QG +S W++R+ K D L L +E RA+ E KL S D+ +QLE K+D+ E +D++ N + +L EP P + PV S +S+L+ K H S TF+ P +C +CTS M+G QG C+ CSF CH C N + A + G +++ GIGT Y+ F+++PKP G+++GW+R + +CD KLF ++V EG + TQ ++ +V+DL+ EF V V +V+HA +KDV I +++ S+ + + VL ES K + ++E +S + K+ R++ +N ++ + LSAAI+D+ + GTEEGL +++T + + K V+ I+ + ++ ++V ++ + R + L G L+GA + + K C G + PG P+ + AA K V Y + H K+ ++ V L + E+L +G A+ +L SP + D + ++ Q +++ +E+ NE L+ F GI+++ R++R +L WP P + + YL +++ G+ +++ H+ VQ + LR +PL+ G + E + LIY SA ++I +T D + T S KFL K P + RD P ++S + IS P NF H++HMGP Q L+DL
Sbjct: 1 MRLHRDDFEMLKVIGRGAFGEVAVVKMKNTERVYAMKILNKWEMLKRAETACFREERDVLVNG---DCQWITTLHYAFQDDNYLYLVMDYYVGGDLLTLLSKFEDRLPEDMSKFYVAEMVLAIHSIHQQHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMMQDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHITDVSEDAKDLIQRLICSRERRLGQNGIQEFKKHAFFTGIDWENIRSTEAPYIPDVSSPSDTSNFDVDDDVLKNPDIAPPMSHTGFTGQHLPFVGFTYTTESCFSDRGRLRLAALADGGLGEGLRSSEDGGLQLEAFERRIRSLEQEKQELNRKLQESTQAAQSLYGSGRGTGTLGRDKEIKKLNEEIDRLKKKLADSDRLEHQLEEAVTLRQDYESSSTKLKALDKQVKALRQEKEDIHKQLVESLERLKSQTKELKDAHQQRKLAMQEFSE----LNERMAELRSQKQRLSRQLRDKEEEMDVVMQKIDAMRQDFRKTEKARKELEAQLEDARAEASKERKLREHSEVYSKQLEGELETLKGSGRASGASAETQQELTKVKSELDKKVLFYEEELVRREACHSTELKNLRKELHDSESQQLSLHKELLVLKDKLEKAKRERQTEMDEAVGTLKDKYERERNLLTEENRKLTSETDRLCTFVDKLTAQNRQLEDELQDLASKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELESLRSSSLGSRHLQGSGMSTPTQKSLVAFRSTKRDPLWKVRRSQKLDMSARLELQSALDAEIRAKQLVQEELRKVKAANISFESKLKDADSRNRDLEEQLEGMKKDLEESRSRTDRGLKLPDFQDSIFEYFNTSPLAHDLTFRDSVSSSSASSLLAFWDEEPAKPP--ATTPVAPSPVYQSSLLTEPKPKA------HQLSIKTFSSPTQCTHCTSLMVGLIRQGYACEVCSFICHVSCKDNAPQVCPIPPEQAKRPLGIDVQRGIGTAYKGFVRIPKPTGVKKGWQRAYAVVCDCKLFLYEVPEGKS-TQPVVVA---SQVLDLRDEEFSVSSVLASDVIHATRKDVPCIFRVTSSTLSSPVRAVSLLVLAESEAEKRKWVGILEGLQSILAKNRLKNRVVHVLHEAYDNSLPAI--KTTLSAAIVDRERIALGTEEGLFVVEITRDIIVRAADCKKVHQIDLIPKE--KMVVLLCGRNRHVHLHPWGALEGAEAAFDVKLTETKGCQALTTG--VLRPGG-------------------PA-----CLLAAIKRQVLCYEITRAKPHHRKMWEVQAPGVVQWLGMV--RERLCVGYPSGFALLALQGESSP----VSLVSPGDPSLAFLAQQPLDALHAMEVGANELLLCFSQLGIYVDAQGRRSRTQELMWPATPLACSSNSTYLTVYSDY-GVDVFDV--HTTEWVQTISLRKIRPLNVEGSLNLLGTEQPR---LIYFSNNSAEGYDLAIPETSDNSKKLMVRTRSKRKFLFK--------------------VPEEERIQQRREMLRD-PEMRS-KLISNPTNFNHVAHMGPGDGMQVLMDL 1547
BLAST of Serine/threonine kinase vs. Ensembl Cavefish
Match: cdc42bpb (CDC42 binding protein kinase beta (DMPK-like) [Source:ZFIN;Acc:ZDB-GENE-030131-3647]) HSP 1 Score: 446.047 bits (1146), Expect = 5.003e-129 Identity = 293/800 (36.62%), Postives = 439/800 (54.87%), Query Frame = 2
Query: 251 LRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD--FNANHEGPPLS-SNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIF-SHPVYQQLVTDKE--KLLTQCQNYDYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQK-----KQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSL------SEENVELRSSLQEI-SNKNMKFHFRLKTILDKEIVKTSENSELLTEL----DREVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIANLKS 2581
+R+ R DF+ ++VIGRGAFG+V+VV+ K +YAMK L+K+++LK+ + ACF+EERDVL WIT LHYAFQD+ YLY VMD+Y GGD+LTLLSKF DRLPE+++KFY+AE+V++I +H+ Y+HRDIKPDN+LLD GHI LADFGSC+++ +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN E FQ P+ DVS++A+DLI++LIC +E RLG GI +FK H FF IDW+N+RS AP+IP+VSS DTSNF+ DD PP+S + F G HLP +GFT+T + F++ G +RL +L + L + +A + L+ +L ++L E T + Q ++ S L DKE KL + L + ++ L E L ++ E +S +L+ L K +Q+ E+ K + E+ +LKS K + + + + L++Q E E M +LRS+ ++ ++R K + +++ D + ++ K+ KE+ E D E K E S + + QL+ ++++L S + E + L ++ S + K F + ++ +E ++E L EL +++ L K L V D +KA+ ERQ L+ + ++ ++ N L SE KLT Q ++QLE QD+ K +A+ ++
Sbjct: 1 MRLHRDDFEMLKVIGRGAFGEVAVVKMKNTERVYAMKILNKWEMLKRAETACFREERDVLVNG---DCQWITTLHYAFQDDNYLYLVMDYYVGGDLLTLLSKFEDRLPEDMSKFYVAEMVLAIHSIHQQHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMMQDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHITDVSEDAKDLIQRLICSRERRLGQNGIQEFKKHAFFTGIDWENIRSTEAPYIPDVSSPSDTSNFDVDDDVLKNPDIAPPMSHTGFTGQHLPFVGFTYTTESCFSDRG----RLRLAALADGGLGEGLRSSEDGGLQLEAFERRIRSLEQEKQELNRKLQES-TQAAQSLYGSGRGTGTLGRDKEIKKLNEEIDRLKKKLADSDRLEHQLEEAVTL--RQDYESSSTKLKALDKQVKALRQEKEDIHKQLVESLERLKSQTKELK-------------------DAHQQRKLAMQ----------EFSELNERMAELRSQKQRLSRQLRDKEEEMDVVMQKIDAMRQDFRKTEKARKELEAQLE-------DARAEASKERKLREHSEVYSK--QLEGELETLKGSGRASGASAETQQELTKVKSELDKKVLFYEEELVRREACHSTELKNLRKELHDSESQQLSLHKELLVLKDKLEKAKRERQTEMDEAVGTLKDKYERERNLLTEENRKLTSETDRLCTFVDKLTAQ-------NRQLEDELQDLASKKESVAHWEA 745 HSP 2 Score: 207.994 bits (528), Expect = 2.073e-53 Identity = 176/651 (27.04%), Postives = 301/651 (46.24%), Query Frame = 2
Query: 2702 HVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGK--GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIENSST---MLPIYVLFESVDNKEDCIKVIEEARSYIKKDP-HYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRP-DLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSS--SNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQ-LIDL 4618
H S TF+ P +C +CTS M+G QG C+ CSF CH C N + A + G +++ GIGT Y+ F+++PKP G+++GW+R + +CD KLF ++V EG + TQ ++ +V+DL+ EF V V +V+HA +KDV I +++ S+ + + VL ES K + ++E +S + K+ R++ +N ++ + LSAAI+D+ + GTEEGL +++T + + K V+ I+ + ++ ++V ++ + R + L G L+GA + + K C G + PG P+ + AA K V Y + H K+ ++ V L + E+L +G A+ +L SP + D + ++ Q +++ +E+ NE L+ F GI+++ R++R +L WP P + + YL +++ G+ +++ H+ VQ + LR +PL+ G + E + LIY SA ++I +T D + T S KFL K P + RD P ++S + IS P NF H++HMGP Q L+DL
Sbjct: 955 HQLSIKTFSSPTQCTHCTSLMVGLIRQGYACEVCSFICHVSCKDNAPQVCPIPPEQAKRPLGIDVQRGIGTAYKGFVRIPKPTGVKKGWQRAYAVVCDCKLFLYEVPEGKS-TQPVVVA---SQVLDLRDEEFSVSSVLASDVIHATRKDVPCIFRVTSSTLSSPVRAVSLLVLAESEAEKRKWVGILEGLQSILAKNRLKNRVVHVLHEAYDNSLPAI--KTTLSAAIVDRERIALGTEEGLFVVEITRDIIVRAADCKKVHQIDLIPKE--KMVVLLCGRNRHVHLHPWGALEGAEAAFDVKLTETKGCQALTTG--VLRPGG-------------------PA-----CLLAAIKRQVLCYEITRAKPHHRKMWEVQAPGVVQWLGMV--RERLCVGYPSGFALLALQGESSP----VSLVSPGDPSLAFLAQQPLDALHAMEVGANELLLCFSQLGIYVDAQGRRSRTQELMWPATPLACSSNSTYLTVYSDY-GVDVFDV--HTTEWVQTISLRKIRPLNVEGSLNLLGTEQPR---LIYFSNNSAEGYDLAIPETSDNSKKLMVRTRSKRKFLFK--------------------VPEEERIQQRREMLRD-PEMRS-KLISNPTNFNHVAHMGPGDGMQVLMDL 1537
BLAST of Serine/threonine kinase vs. Ensembl Cavefish
Match: cdc42bpb (CDC42 binding protein kinase beta (DMPK-like) [Source:ZFIN;Acc:ZDB-GENE-030131-3647]) HSP 1 Score: 446.047 bits (1146), Expect = 6.313e-129 Identity = 292/798 (36.59%), Postives = 437/798 (54.76%), Query Frame = 2
Query: 251 LRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD--FNANHEGPPLS-SNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIF-SHPVYQQLVTDKE--KLLTQCQNYDYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQK-----KQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSL------SEENVELRSSLQEI-SNKNMKFHFRLKTILDKEIVKTSENSELLTEL----DREVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIANL 2575
+R+ R DF+ ++VIGRGAFG+V+VV+ K +YAMK L+K+++LK+ + ACF+EERDVL WIT LHYAFQD+ YLY VMD+Y GGD+LTLLSKF DRLPE+++KFY+AE+V++I +H+ Y+HRDIKPDN+LLD GHI LADFGSC+++ +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN E FQ P+ DVS++A+DLI++LIC +E RLG GI +FK H FF IDW+N+RS AP+IP+VSS DTSNF+ DD PP+S + F G HLP +GFT+T + F++ G +RL +L + L + +A + L+ +L ++L E T + Q ++ S L DKE KL + L + ++ L E L ++ E +S +L+ L K +Q+ E+ K + E+ +LKS K + + + + L++Q E E M +LRS+ ++ ++R K + +++ D + ++ K+ KE+ E D E K E S + + QL+ ++++L S + E + L ++ S + K F + ++ +E ++E L EL +++ L K L V D +KA+ ERQ L+ + ++ ++ N L SE KLT Q ++ D + L K+ V + IA +
Sbjct: 1 MRLHRDDFEMLKVIGRGAFGEVAVVKMKNTERVYAMKILNKWEMLKRAETACFREERDVLVNG---DCQWITTLHYAFQDDNYLYLVMDYYVGGDLLTLLSKFEDRLPEDMSKFYVAEMVLAIHSIHQQHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMMQDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHITDVSEDAKDLIQRLICSRERRLGQNGIQEFKKHAFFTGIDWENIRSTEAPYIPDVSSPSDTSNFDVDDDVLKNPDIAPPMSHTGFTGQHLPFVGFTYTTESCFSDRG----RLRLAALADGGLGEGLRSSEDGGLQLEAFERRIRSLEQEKQELNRKLQES-TQAAQSLYGSGRGTGTLGRDKEIKKLNEEIDRLKKKLADSDRLEHQLEEAVTL--RQDYESSSTKLKALDKQVKALRQEKEDIHKQLVESLERLKSQTKELK-------------------DAHQQRKLAMQ----------EFSELNERMAELRSQKQRLSRQLRDKEEEMDVVMQKIDAMRQDFRKTEKARKELEAQLE-------DARAEASKERKLREHSEVYSK--QLEGELETLKGSGRASGASAETQQELTKVKSELDKKVLFYEEELVRREACHSTELKNLRKELHDSESQQLSLHKELLVLKDKLEKAKRERQTEMDEAVGTLKDKYERERNLLTEENRKLTSETDRLCTFVDKLTAQNRQLEDELQDLASKKESVAHWEAQIAEI 750 HSP 2 Score: 207.994 bits (528), Expect = 2.583e-53 Identity = 177/652 (27.15%), Postives = 300/652 (46.01%), Query Frame = 2
Query: 2702 HVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGK---GANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIENSST---MLPIYVLFESVDNKEDCIKVIEEARSYIKKDP-HYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRP-DLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSS--SNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQ-LIDL 4618
H S TF+ P +C +CTS M+G QG C+ CSF CH C N C K G +++ GIGT Y+ F+++PKP G+++GW+R + +CD KLF ++V EG + TQ ++ +V+DL+ EF V V +V+HA +KDV I +++ S+ + + VL ES K + ++E +S + K+ R++ +N ++ + LSAAI+D+ + GTEEGL +++T + + K V+ I+ + ++ ++V ++ + R + L G L+GA + + K C G + PG P+ + AA K V Y + H K+ ++ V L + E+L +G A+ +L SP + D + ++ Q +++ +E+ NE L+ F GI+++ R++R +L WP P + + YL +++ G+ +++ H+ VQ + LR +PL+ G + E + LIY SA ++I +T D + T S KFL K P + RD P ++S + IS P NF H++HMGP Q L+DL
Sbjct: 976 HQLSIKTFSSPTQCTHCTSLMVGLIRQGYACEVCSFICHVSCKDNA-PQVCPIPPEQAKRPLGIDVQRGIGTAYKGFVRIPKPTGVKKGWQRAYAVVCDCKLFLYEVPEGKS-TQPVVVA---SQVLDLRDEEFSVSSVLASDVIHATRKDVPCIFRVTSSTLSSPVRAVSLLVLAESEAEKRKWVGILEGLQSILAKNRLKNRVVHVLHEAYDNSLPAI--KTTLSAAIVDRERIALGTEEGLFVVEITRDIIVRAADCKKVHQIDLIPKE--KMVVLLCGRNRHVHLHPWGALEGAEAAFDVKLTETKGCQALTTG--VLRPGG-------------------PA-----CLLAAIKRQVLCYEITRAKPHHRKMWEVQAPGVVQWLGMV--RERLCVGYPSGFALLALQGESSP----VSLVSPGDPSLAFLAQQPLDALHAMEVGANELLLCFSQLGIYVDAQGRRSRTQELMWPATPLACSSNSTYLTVYSDY-GVDVFDV--HTTEWVQTISLRKIRPLNVEGSLNLLGTEQPR---LIYFSNNSAEGYDLAIPETSDNSKKLMVRTRSKRKFLFK--------------------VPEEERIQQRREMLRD-PEMRS-KLISNPTNFNHVAHMGPGDGMQVLMDL 1558
BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004595.1 (pep scaffold:Pmarinus_7.0:GL477044:11103:63873:-1 gene:ENSPMAG00000004137.1 transcript:ENSPMAT00000004595.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 372.089 bits (954), Expect = 2.553e-106 Identity = 206/543 (37.94%), Postives = 316/543 (58.20%), Query Frame = 2
Query: 134 LIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFR--EIDWDNLRSYNAPFIPEVSSAEDTSNF-EFDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQL-----------NECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNK 1720
L D L+ + P + KNV F++ V K+ LR+R D+D+++VIGRGAFG+V +VR K +YAMK L+K +++K+ D+A F EERD++ A SPWI +L Y+FQD+ YLY VM++ GGD++ L+S ++ +PE+ +FY AEVV+++D +H +GY+HRD+KPDN+LLD GH+ LADFG+C+KL +G + AVGTPDYISPE+LRS G G YG ECDWWS+G+ + EML G+ PFY E TY +IM+ + P + D+S A+ LI + +++ RLG G + K H FF+ + W+N+R +AP +PE+SS DTSNF E ++ + E P F G LP +GFT+ KD +L S G PA+ GN+ E + +E +++KI LE+Q+ +CR N+ R+ ++L+ D E+ +N + LR+ E+ L++ + + R + SD KK+ ++ ++ + E +LK N+
Sbjct: 1 LQDGLYALVLDLDFPALRKNKNVESFLQRYGEAVGKVRDLRMRADDYDSVKVIGRGAFGEVQLVRHKVTKSVYAMKLLNKLEMIKRSDSAFFWEERDIMAFA---NSPWIVQLFYSFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLAVDAIHSMGYIHRDVKPDNMLLDKSGHLKLADFGTCMKLNKDGMVRCDTAVGTPDYISPEVLRSQGGQGYYGRECDWWSVGVFLFEMLVGDTPFYAESLVGTYGKIMDHKKSLTFPVDL-DISKNAKSLICAFLTERDVRLGKNGFAEIKCHDFFKNDQWTWENIRETSAPVVPELSSDTDTSNFDEIENDKSADETFPQPKAFVGNQLPFVGFTYYKDH------------QLLS-----GVPAVA-GNNEEPLKSSQVEISHKMKI--EMLERQMKNAVQVKDEAEQKCR-NANSRL------EKLLKDLEEECVSRKNLEAQLRQMERD-KALVQHKMVEQQRRADAESD------KKRHLDGEVNSLKEQLEELKKKNQ 503
BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003561.1 (pep scaffold:Pmarinus_7.0:GL478057:5187:43749:1 gene:ENSPMAG00000003167.1 transcript:ENSPMAT00000003561.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 368.622 bits (945), Expect = 4.196e-105 Identity = 174/407 (42.75%), Postives = 260/407 (63.88%), Query Frame = 2
Query: 194 KNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFR--EIDWDNLRSYNAPFIPEVSSAEDTSNF-EFDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDF-IFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQL 1402
KN+ F+ + V K+ LR+R +D+D ++VIGRGAFG+V +VR K ++YAMK L K+++ K+ D+A F EERD++ A SPW+ +L YAFQD YLY VM++ GGD++ L+S ++ +PE+ +FY AEVV+++D +H +G++HRD+KPDN+LLD GH+ LADFG+C+K+ G + AVGTPDYISPE+L+S G G YG ECDWWS+G+ ++EML G+ PFY + TY +IM+ + P + D+S +A++LI + +E R+G G+ + K HPFF+ + W+N+R AP +PE+ S DTSNF E ++ A E P+ F G LP +GFT+ D+ +F+ G+E + AL+N S D L ++V QL
Sbjct: 50 KNIDNFLNRYEKAVGKVRDLRMRANDYDVVKVIGRGAFGEVQLVRHKATKKVYAMKLLSKFEMTKRSDSAFFWEERDIMAFA---NSPWVVQLFYAFQDHRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKNGHLKLADFGTCMKMDTEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNALNFPDDV-DISKDAKNLICAFLIDREVRVGRNGVGEIKRHPFFKNDQWTWENIRETAAPVVPELVSDTDTSNFDEIEEDKAEDETFPVPKAFSGNQLPFVGFTYYSDYQLFSVNGTEVNR-------------ALMNQPRQSSVVDKLHQKVYQL 437
BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006413.1 (pep scaffold:Pmarinus_7.0:GL485553:3974:11158:-1 gene:ENSPMAG00000005799.1 transcript:ENSPMAT00000006413.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 289.656 bits (740), Expect = 6.492e-88 Identity = 154/347 (44.38%), Postives = 217/347 (62.54%), Query Frame = 2
Query: 230 TVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFR--EIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDFN----ANHEGPPLSSNFKGCHLPCIGFTF 1252
V K+ LR+ DF+ ++VIGRGAFG V +VR K+ ++AMK L+K ++LK+ D+A F EERD++ A S WI +L AFQDE YLY VM++ GGD+++L+S ++ +PE+ +FY AEVV+++D +H +G++HRDIKPDN+LLD LGH+ LADFG+C+K+ G + AVGTPDYISPE+L+S G G YG+ + +G + G+ PFY E TY +IM+ P + VS EA LI + +E RLG G+D+ K HPFFR + W N+R AP +PE++S D S FDD + A E + F G LP IGFT+
Sbjct: 3 AVGKVHDLRMNVHDFELLKVIGRGAFGVVQLVRHKQTRRVHAMKRLNKGEMLKRSDSAFFWEERDIMAFA---NSSWIIQLFSAFQDERYLYMVMEYMPGGDLVSLMSNYD--VPEKWARFYTAEVVLALDAIHSMGFIHRDIKPDNMLLDRLGHLKLADFGTCMKMDAEGMVRSNTAVGTPDYISPEVLKSQGGDGYYGLH-EPPEIGNHLVAAHAGDTPFYAESLVGTYSKIMDHRNSLCFPDDA-SVSKEARSLICAFLTDREVRLGRTGVDEIKRHPFFRNDQWTWQNIRETVAPVVPELASDADASC--FDDISEQEKAEEEAFSVPKAFLGNQLPFIGFTY 340
BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Match: stk38l (serine/threonine kinase 38 like [Source:ZFIN;Acc:ZDB-GENE-040426-798]) HSP 1 Score: 239.58 bits (610), Expect = 3.530e-70 Identity = 128/320 (40.00%), Postives = 183/320 (57.19%), Query Frame = 2
Query: 314 VSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKL------------------------------------RPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFE 1165
V +V+ K+ G IYAMK L K D+L+K A + ERD+L +A + W+ ++ Y+FQD LY +M+F GGDM+TLL K D L EE T+FYIAE +++ID +H+LG++HRDIKPDNLLLDS GH+ L+DFG C L + N + VGTPDYI+PE+ Y CDWWSLG+++ EML G PF +E ETY ++M++ P E +S+++ DLI + C+ E R+G G+++ K H FF +DW+++R A E+ S +DTSNF+
Sbjct: 1 VRLVQKKDTGHIYAMKVLRKADMLEKEQVAHIRAERDILVEADNL---WVVKMFYSFQDPKNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAESILAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRDLTQAQPSDFSTSSKPMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFLQTG----YNKLCDWWSLGVIMFEMLIGYPPFCSESPQETYRKVMHWRETLVFPPEV-PISEKSRDLILRFCCEAENRVGANGVEEIKTHAFFEGVDWEHMRERPAAIPIEIKSIDDTSNFD 311
BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000997.1 (pep scaffold:Pmarinus_7.0:GL485486:573:10798:1 gene:ENSPMAG00000000902.1 transcript:ENSPMAT00000000997.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 227.639 bits (579), Expect = 2.143e-62 Identity = 191/664 (28.77%), Postives = 302/664 (45.48%), Query Frame = 2
Query: 2702 HVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYC------LSNVLNDKCYTRKSAGKGANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDP-HYRMIFTEKSCLNNLDISMNY-RQILSAAIIDQSTLLFGTEEG--LLKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHL--NLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESML-IVEI-----SFNEYLILFECAGIFINRNHRQTR-PDLQWPDKPTRFTYRAPYLLCFTE-MAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDS-FDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQ-LIDL 4618
H TF+ P KC C+S MLG QG C+ C FSCH C + + D+ TR+ G + + G GT YE +++VPKP G+++GW+R + +CDLKL FD+ EG T +P++ + VID++ EF V V +V+HA +KDV I +++ + T L +L ++ KE + V+ E + +K++ R ++ + + + Y + LSAA+ID + G E+G +L+VT+ ++ + K V IE + E QLVAVI + R L+L L L+G + EP V K+C G+ P + ++ ++C A K + Y L TRH ++R+ L + G + +G AIY+ +D ++F L VEI EYL+ F C GI+++R R++R +L WP PT Y PYL ++E +F E +Q LPL+ KPL+ G + +E ++ LIY A E + + +T D + + + ++R SY +D + I RD P L+S + IS P NF H++HMGP Q L+DL
Sbjct: 3 HSLVVRTFSSPTKCSQCSSLMLGLVRQGCACEVCGFSCHVTCAEKAPQVCPIPADQ--TRRPLG--IDPQRGTGTAYEGYVRVPKPAGVKKGWQRAYAVVCDLKLVLFDIPEGKTA--LPNVGVS--HVIDMRDEEFSVSSVLASDVIHANRKDVPSIFRVTATQLTTPRTRLSTLILADTETEKERWVGVLSELQRLLKRNKLKDRAVYQAREAFES---GLPYIKTTLSAAVIDHDRIALGAEDGFYVLEVTNDVIVRVDDCKKVTQIELIP--EAQLVAVITGRNRQLRLYLWKALEGM-EHEPYKVPEAKNCQAIAAGR----------PSGLSAAGSA-------------LLCLAMKRQLVCYELMGGAARTRHRRIREYQLPNVAQWLAVLSEG--ICVGYQSGFAIYATGAGEEGSGHCLVQAEDPSLSFLAAGGGAPADALCCVEIVGGPGPAREYLLCFSCVGIYVDRQGRRSRQQELMWPAPPTACCYNPPYLSVYSENTVDIFNIITME----WIQTLPLKKIKPLNPQGTLNLLPSEPVR---LIYFQNKQAEGEDLHVPETSDNSRK----QLIRMRSRRHFSYRVPDDEKISLREMI---------------IRD-PELRS-KLISGPTNFNHVAHMGPGDGMQMLMDL 599
BLAST of Serine/threonine kinase vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649]) HSP 1 Score: 211.075 bits (536), Expect = 3.459e-60 Identity = 123/319 (38.56%), Postives = 185/319 (57.99%), Query Frame = 2
Query: 266 SDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKEC-RLGN--KGIDDFKNHPFFREIDWDNL--RSYNAPFIPEVSSAE-DTSNFEF---DDFNANHEG 1195
SDF +R +G G+FG+V ++R G YA+K+L K+ I+K +ER +L + P+I R+ FQD ++ VMD+ GG++ +LL K + R P + KFY AEV ++++ +H ++RD+KP+N+LLD GHI + DFG K P+ +T GTPDYI+PE++ + PY DWWS G++I+EML G PFYN + +TY I+N E F P + D A+DL+K+LI + RLGN G +D KNHP+F E+ W+ L R P+ P + + DTS F+ ++FN +G
Sbjct: 86 SDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRML---SIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRK-SQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFG-FAKYVPD---VTYTLCGTPDYIAPEVVSTK----PYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNAELKFP-PFFHPD----AQDLLKKLITRDLSERLGNLQNGSEDVKNHPWFNEVIWEKLLARYIETPYEPPIQQGQGDTSQFDRYPEEEFNYGIQG 387
BLAST of Serine/threonine kinase vs. Ensembl Yeast
Match: TPK1 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication [Source:SGD;Acc:S000003700]) HSP 1 Score: 206.838 bits (525), Expect = 9.441e-59 Identity = 123/332 (37.05%), Postives = 192/332 (57.83%), Query Frame = 2
Query: 188 DEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKK-ECRLGN--KGIDDFKNHPFFREIDWDNLRSYN--APFIPEVSSAE-DTSNFE 1165
+E+ QFI + T K SL+ DF +R +G G+FG+V ++R + G YAMK L K +++ +ER +L + P+I R+ FQD ++ +MD+ GG++ +LL K + R P + KFY AEV ++++ +H ++RD+KP+N+LLD GHI + DFG K P+ +T GTPDYI+PE++ + PY DWWS GI+I+EML G PFY+ + +TY +I+N E F P ++ ++ +DL+ +LI + RLGN G +D KNHP+F+E+ W+ L S N P+ P + + DTS F+
Sbjct: 64 NEEQYKQFIAQARVTSGKY-SLQ----DFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLML---SIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRK-SQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFG-FAKYVPD---VTYTLCGTPDYIAPEVVSTK----PYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRF--PPFFN---EDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFD 373
BLAST of Serine/threonine kinase vs. Ensembl Yeast
Match: YPK1 (S/T protein kinase; phosphorylates, downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p by phosphorylation in response to compromised sphingolipid synthesis; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; human homolog SGK1 can complement a null mutant; human homolog SGK2 can complement a ypk1 ypk2 double mutant [Source:SGD;Acc:S000001609]) HSP 1 Score: 213.772 bits (543), Expect = 1.924e-58 Identity = 121/302 (40.07%), Postives = 182/302 (60.26%), Query Frame = 2
Query: 269 DFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKEC-RLGNKGIDDFKNHPFFREIDWDNL--RSYNAPFIPEVSSAEDTSNFE 1165
DFD ++VIG+G+FGKV VR K+ ++YA+K++ K I+ K + ER VL ++ P+I L ++FQ LYFV+ F NGG++ L K R +FY AE++ ++D +HKL ++RD+KP+N+LLD GHI L DFG C KL T+ GTP+Y++PE+L G G Y DWW+LG++++EML G P+Y+ED + Y +I+ F P +D +A+DL+ L+ + RLG G D+ +NHPFF ++ W L + Y P+ P VS++ DTSNF+
Sbjct: 346 DFDLLKVIGKGSFGKVMQVRKKDTQKVYALKAIRKSYIVSKSEVTHTLAERTVL---ARVDCPFIVPLKFSFQSPEKLYFVLAFINGGELFYHLQK-EGRFDLSRARFYTAELLCALDNLHKLDVVYRDLKPENILLDYQGHIALCDFGLC-KLNMKDDDKTDTFCGTPEYLAPELLL---GLG-YTKAVDWWTLGVLLYEMLTGLPPYYDEDVPKMYKKILQEPLVF--PDGFD---RDAKDLLIGLLSRDPTRRLGYNGADEIRNHPFFSQLSWKRLLMKGYIPPYKPAVSNSMDTSNFD 633
BLAST of Serine/threonine kinase vs. Ensembl Yeast
Match: YPK2 (Protein kinase similar to S/T protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); human homolog SGK2 can complement a ypk1 ypk2 double mutant [Source:SGD;Acc:S000004710]) HSP 1 Score: 212.616 bits (540), Expect = 5.355e-58 Identity = 122/302 (40.40%), Postives = 180/302 (59.60%), Query Frame = 2
Query: 269 DFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKEC-RLGNKGIDDFKNHPFFREIDWDN--LRSYNAPFIPEVSSAEDTSNFE 1165
DFD ++VIG+G+FGKV VR K+ +IYA+K+L K I+ K + ER VL ++ P+I L ++FQ LY V+ F NGG++ L + R ++FYIAE++ ++D +HKL ++RD+KP+N+LLD GHI L DFG C KL T+ GTP+Y++PEIL G G Y DWW+LGI+++EM+ G P+Y+E+ Y +I+ F P +D A+DL+ L+ + RLG G D+ +NHPFF++I W L+ Y P+ P V S DT+NF+
Sbjct: 343 DFDLLKVIGKGSFGKVMQVRKKDTQKIYALKALRKAYIVSKCEVTHTLAERTVL---ARVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFYHL-QHEGRFSLARSRFYIAELLCALDSLHKLDVIYRDLKPENILLDYQGHIALCDFGLC-KLNMKDNDKTDTFCGTPEYLAPEILL---GQG-YTKTVDWWTLGILLYEMMTGLPPYYDENVPVMYKKILQQPLLF--PDGFDPA---AKDLLIGLLSRDPSRRLGVNGTDEIRNHPFFKDISWKKLLLKGYIPPYKPIVKSEIDTANFD 630
BLAST of Serine/threonine kinase vs. Ensembl Yeast
Match: TPK2 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000006124]) HSP 1 Score: 194.897 bits (494), Expect = 8.203e-55 Identity = 110/304 (36.18%), Postives = 174/304 (57.24%), Query Frame = 2
Query: 269 DFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGN--KGIDDFKNHPFFREIDWDNL--RSYNAPFIPEVSSA-EDTSNFE 1165
DF +R +G G+FG+V +VR G YA+K L K ++K +ER +L ++ P++ R+ FQD ++ VMD+ GG++ +LL K + R P + KFY AEV+++++ +H ++RD+KP+N+LLD GHI + DFG +++ T+T GTPDYI+PE++ + PY DWWSLG++I+EML G PFY+ +TY +I+ + + P + DV D LI + + R+GN G D K HP+F E+ W+ L + P+ P ++S DTS F+
Sbjct: 69 DFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRML---KLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRK-SQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQ----TVTWTLCGTPDYIAPEVITTK----PYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQGKVVYP-PYFHPDVVDLLSKLITADLTR---RIGNLQSGSRDIKAHPWFSEVVWERLLAKDIETPYEPPITSGIGDTSLFD 356
BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Match: EDO37677 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SF23]) HSP 1 Score: 320.472 bits (820), Expect = 2.232e-97 Identity = 165/395 (41.77%), Postives = 252/395 (63.80%), Query Frame = 2
Query: 119 VTLEFLIDSLFCTYYECRLP-FHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGH-GPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNF-EFD------------DFNANHEGPPLSSNFKGCHLPCIGFTFTK 1258
V+ E L+D+ + EC K +KN+A F+K + ++++ L + ++DF+ + IGRG FG+V VV+ K G++YAMK+L K L + A F+EER+++ A +PWIT L YAFQD LY VMD++ GGD+L+LLSK++D E++ +FY+AE+VM+I +H +G++HRD+KPDN+L+D GHI LADFGS +L + ++ VGTP+YI+PE+L S +G G YGVECDWWSLG+V +EML+G+ PF + TY +IMNF++ + P+E +S++A++LI L+ E R+G +G+ H FF I+W+ L++ P++P + +DTSNF EF+ F + +G FKG LP +GF+F K
Sbjct: 30 VSREALLDAFTVLFEECSSDHMKKKDKNIATFVKKYQPMINELRRLSLSKNDFNVVNTIGRGHFGEVQVVKDKATGDVYAMKTLKKSQTLSEEAVAFFEEEREIMATA---NNPWITSLQYAFQDSHSLYLVMDYHPGGDLLSLLSKYDDIFEEDMARFYLAEIVMAIHSLHTMGFVHRDVKPDNVLIDRTGHIKLADFGSSARLSADKKVFSKMPVGTPEYIAPEVLTSMDGSGGAYGVECDWWSLGVVAYEMLFGQTPFEADSVVVTYSKIMNFKSSLRFPSE-PKISEDAKELIHNLLTSSEGRIGYEGLG---CHKFFNGIEWNKLQNTLPPYVPTLDGTDDTSNFDEFEPDSDEMDQLKKYSFCSEEKG------FKGKDLPFVGFSFIK 411
BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Match: EDO32008 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SW88]) HSP 1 Score: 271.937 bits (694), Expect = 2.338e-82 Identity = 123/263 (46.77%), Postives = 183/263 (69.58%), Query Frame = 2
Query: 134 LIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETY 922
L+D + +C P + KNV F++ + I++ R+ DF T++VIGRGAFG+V +VR ++YAMK L K++++K+ D+A F EER+++ + S WI +LHYAFQDE YLY VMD+ +GGD++ L+S + +PE+ KFY AEVV+++D +H +G++HRD+KPDN+LLD GH+ LADFG+C+++ +G ++ AVGTPDYISPE+L+S G G YG ECDWWS+G+ ++EML G+ PFY + TY
Sbjct: 21 LLDGIEALVNDCNFPQLRRNKNVENFLQRYEQPTRVIQTHRLNNDDFKTLKVIGRGAFGEVQLVRHTHTKKVYAMKLLSKFEMIKRSDSAFFWEEREIMAHS---NSNWIVKLHYAFQDEKYLYMVMDYMSGGDLVNLMSNYE--IPEKWAKFYCAEVVLALDAIHTMGFVHRDVKPDNMLLDGEGHLKLADFGTCMRMDRDGMVRSDTAVGTPDYISPEVLKSQGGEGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTY 278
BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Match: EDO42700 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0M7]) HSP 1 Score: 263.848 bits (673), Expect = 3.728e-77 Identity = 152/379 (40.11%), Postives = 221/379 (58.31%), Query Frame = 2
Query: 239 KIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLR-------------------PNGTTITER----------------AVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIF 1270
+++ RI + DFD+++VIGRGAFG+V +V+ ++ G +YAMK L K D+L+K A + ERD+L +A ++ W+ +++Y+FQD++YL+ VM+F GGD++TLL K D EE T+FYIAE +++ID +H+LG++HRDIKPDNLLLDS GHI LADFG C L+ NG + + VGTPDYI+PE+ +G Y CD+WSLG++++EML G PF +E ETY ++MN+ P E +S A DLI + RL N I+D + PFF+ +DW+NLR A +V S +DTSN FD+F S++ C T +KD++F
Sbjct: 83 RLKRSRIGKEDFDSLKVIGRGAFGEVRLVQKQDTGHVYAMKILRKADMLEKEQVAHARAERDILAEA---ENQWVVKMYYSFQDDYYLFLVMEFLPGGDLMTLLMK-KDTFTEEETRFYIAEALLAIDSIHQLGFIHRDIKPDNLLLDSRGHIKLADFGLCTGLKKAHRTEFYRDISPADIKDFSNGDPLDSKRRAATWKRNRRQLAYSTVGTPDYIAPEVF-IQQG---YTKSCDFWSLGVIMYEMLIGYPPFCSESPQETYKKVMNWRETLVFPPEM-PISPNARDLISRQ------RLSN--IEDIRAQPFFKYVDWENLRDRPAALPIQVKSIDDTSN--FDEFPETDLDTSKSNSLLLC-------THSKDWVF 435
BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Match: EDO36034 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJR1]) HSP 1 Score: 243.432 bits (620), Expect = 1.721e-70 Identity = 139/382 (36.39%), Postives = 209/382 (54.71%), Query Frame = 2
Query: 191 EKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCV---------------KLRPNGTTITERA-----------------------------------------VGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNL-RSYNAPFIPEVSSAEDTSNFE 1165
+ + Q +K + +++ ++ S F+ IR IG GAFG+V +VR + +YAMK L K ++ ++ AA + ERD+L +A + W+ +L+Y+FQD+ LYFVMD+ GGD+++LL KF PE+ KFYIAE+V++ID VH++G++HRDIKPDN+L+D GHI L DFG C +R + ERA VGTP+YI+PE+L Y CDWWS+G++++EML G+ PF +ET +I+N+ET +IP + +S EA+DLI +L + RLG+ G + K HPFF +DW L + AP+ P + DT+NF+
Sbjct: 11 QSQMRQLLKQKETNYIRLKRTKMDISMFEKIRTIGIGAFGEVWLVRKTDTSMLYAMKILRKSEVFRRNQAAHVKAERDILAEA---DNEWVVKLYYSFQDQENLYFVMDYVPGGDLMSLLIKFGI-FPEDYAKFYIAELVLAIDSVHRMGFVHRDIKPDNILIDKDGHIKLTDFGLCTGFRWTHDSKYYEKGQHMRQDSMEPDERAWEEMRATCHCGDISIDKPYSEMKPLERRHFRKHMRCQAHSLVGTPNYIAPEVLLRIG----YRQSCDWWSVGVILYEMLVGQPPFLAPTPAETQLKIINWETELRIPHQA-RLSREAKDLILRLCTNADMRLGSNGASEIKAHPFFACVDWAYLAKRVQAPYTPVIRFPTDTANFD 383
BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Match: EDO37800 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEW2]) HSP 1 Score: 207.223 bits (526), Expect = 2.955e-58 Identity = 121/310 (39.03%), Postives = 184/310 (59.35%), Query Frame = 2
Query: 254 RIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVK-LRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICK-KECRLGNKGID--DFKNHPFFREIDWDNL--RSYNAPFIPEVSSAEDTSNFE 1165
+ + SDF ++VIG+G+FGKV + + K++ + YA+K L+K I K+ +A ER+VL Q + P++ LHY+FQ + LYFV+D+ NGG++ L + PE +FY AE+ +I +H L ++RD+KP+N+LLDS GHIVL DFG C + + +GTT T GTP+Y++PE+LR + Y DWW LG V++EM+YG PFY+ D +E Y I++ + ++S A +++ L+ K K RLG+ D D + H FFR I+W L R P+ P VS D +F+
Sbjct: 68 KAKPSDFLFLKVIGKGSFGKVFLSKNKQEDKFYAIKVLNKSAIRKRNEAKHIMAERNVLVQ--NVTHPFLVGLHYSFQTKDKLYFVLDYVNGGELFFHLQR-ERYFPESRARFYAAEIASAIGYLHGLQIIYRDLKPENILLDSKGHIVLTDFGLCKEGIDRSGTTST--FCGTPEYLAPEVLRKQD----YDKSVDWWCLGAVLYEMMYGLPPFYSRDTAEMYDNILHKPLRLRT-----NISQSARHILEGLLQKDKTKRLGSGEGDFEDIRTHSFFRSINWQQLVARGIEPPYNPNVSGQLDLKHFD 363
BLAST of Serine/threonine kinase vs. Ensembl Medaka
Match: cdc42bpab (CDC42 binding protein kinase alpha [Source:NCBI gene;Acc:101159789]) HSP 1 Score: 669.078 bits (1725), Expect = 0.000e+0 Identity = 490/1634 (29.99%), Postives = 798/1634 (48.84%), Query Frame = 2
Query: 119 VTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPA--LLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREK---EQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXX---XXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLR----SENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSH-DNEIEQLKISVAEEQSRILASN-TQLK----------SQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSEL---LTELDREVEL-----------LKTLC-------------------VDNDGDQKA-------------QGERQDNNGNES----WRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIANLKSASQNLE--------------------PHVPKEIPSNPVTLSEFNSILSGS------------LDKTVVNCNQ---------HVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGKGA---NLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIEN----SSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDP-HYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIG------MHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFIN-RNHRQTRPDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
+++E L+D L C Y EC + EKN+ +F+ K K++ +R+ + DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL WIT LHYAFQD+ LY VMD+Y GGD+LTLLSKF DRLPE++ KFY+AE+V++ID VH+L Y+HRDIKPDN+LLD GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ P + DVS+EA+DLI++LIC +E RLG GI+DFK HPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N+ PP + F G HLP +GFT+T F++ G L+ L G ++ + D+L E + +I ++L + +T +++ P+ + L T+ + + E E+K++D+ + R L + + Q+ Q+ +E K + E ++LKS +K + + + +L + + L+ Q + +++ + Q+ E + L++R ++ + + E+ + E+++Q ++EE++ LK + K ++ H E+E+ + EE +R A + T+LK SQ +L +E + L+ L + M++ + +T + ++ T EN +L L +L R E +K L V ++ D + +G + + G + W++R+ K D L L +E +A+ ++ +LTQ K++ +L+ + E I +LK ++ L H P+ + + + + S+ S + C H F +F+ P KC+ CTS M+G QG C+ C+FSCH C ++ C + KG+ + + GIGT YE +++VPKP G+++GW+R +CD KLF +++ EG +S +VID++ EF V V +V+HA +KD+ I +++ + SS I +L +S + + ++ E +KK+ R ++ K ++ + Q SAAIID + G EEGL + VT ++G+ K VY I+ + Q+ L+AVI K R ++L+ LDG +VE K C G N + +C A K + Y + + +LR + ++ + + G++L +G + D++A+ SL D +I Q N E++ VEIS E L+ F G++++ HR + +L WP P Y APYL ++E A + +++ ++ +Q +PL+ +PL+ G + ++ + LIY A +++ + +T D++ S + NK+ SF P + RD P ++ N+ IS P NF H++HMGP Q++
Sbjct: 26 LSVETLLDILVCLYDECNNSPLRREKNILEFLDWAKPFTSKVKQMRLHKEDFEILKVIGRGAFGEVAVVKVKNTDKVFAMKILNKWEMLKRAETACFREERDVLVNG---DCQWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMAKFYLAEMVLAIDSVHQLHYVHRDIKPDNILLDKKGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPQQLTDVSEEAKDLIRRLICSREHRLGQNGIEDFKQHPFFSGIDWDNIRTCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPSHTAFSGHHLPFVGFTYTSKCTFSDRGC------LRQLSGERGQTGEDQVDLDVKRRLEDSLATEAYERRI------RRLEQEKTELSRKLHESPLSSTKEVEIRSLKTEIEILKKQIAESGQLEKKLEDVTSSRRDLEDSSKHVRTLEKQLKSLTQERDEMQKDLVEASDRLKSQSKELKEAHSQRKLAMQEFSELNSTLTDLRSAKQRLARQLRDKEEEMETQSQKVEALRLEVRKAERAKKEVLAEEHAAEAQKEKKIRERNEQYSRQLEEELEGLK-VQVASLKTQEVGHLRGEMERKTLLYEEELARREAQHSTELKTLRKELRDAESQQLTLQKEILMLKDKLDQARQIEMEYKQKYET---ERVLLTEENKKLSNDLDKLSRMFEKVSSSHQHLEDEMKELADKKESVAHWEAQITEIIQWVSDEKDARGYLQALATKMTEELEGLKNTSLGARATDMPWKMRRLAKLDMSARLELQSALDAEIKAKQAIQDELTQVKADCFSTEGKLQDMESKNKELLAEIEHLKKETEELRLRRESNICVINQLTLFLQLIDHQPRSVQTPTMRSGGYGSMGRCSPKVSFPPKRRSLFASVPIVCESGVCRLQPKAHQFVVKSFSAPTKCNQCTSLMVGLIRQGCMCEVCNFSCHVTC-ADKAPAVCPVPQDQTKGSLGIDPQRGIGTAYEGYVRVPKPTGVKKGWQRAMAVVCDFKLFLYELGEGKAAQPSVIVS----QVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASHLSASSSQKTSILMLADSDQERNKWVGLLGELHRILKKNKLKDRFVYVPKEAYDSTLPLIKGTQ--SAAIIDHERVALGNEEGLFVIHVTKDEIIRVGDNKKVYQIDPIPQE--HLLAVISGKNRHVRLVPIMALDGRETDCQKLVET-KGCQRIASGPV--------------------------RNGSLMCLCVAMKTKIICYEVRKSHPHYRRLRDVQAPAAIQWMGL--FGDRLYVGYQSGFVIPDNMAMVSLLHP-------------EDHTLAFIPQQNLEALCAVEISSKELLLCFSSIGVYVDSHGHRSRQQELMWPATPNAACYNAPYLSVYSENA-VDVFDV--NTMEWIQTIPLKKVRPLNVDGSLNLLG---LETVRLIYFRNKMAEGDELVVPETSDQSRKQMVRS----------NNNKRRFSFRV-------PEEERLQQRREMLRD-PEMR-NKLISNPTNFNHVAHMGPGDGIQIL 1564
BLAST of Serine/threonine kinase vs. Ensembl Medaka
Match: cdc42bpb (CDC42 binding protein kinase beta [Source:NCBI gene;Acc:101168010]) HSP 1 Score: 640.188 bits (1650), Expect = 0.000e+0 Identity = 491/1649 (29.78%), Postives = 813/1649 (49.30%), Query Frame = 2
Query: 119 VTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD--FNANHEGPPLS-SNFKGCHLPCIGFTFTKDFIFNEMGS----------EESSV----------RLKSLMEN--------------IGAPALLNGNHNESNSDALLEEVNQLKITCS---QLEKQLNECRT------NSVQRIFS-HPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQ-------DIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKC----------------------SNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQ-------VKSLSEENVELRSSLQEISNKNMKF-HFRLKTILDKEIVKTSENSE-----LLTELDREVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARA--------------DLEKKLTQQKSEICDISKQLEKYKQDVNEKDN-----------------------LIANLKSASQNLEPHVPK--EIP-SNPVTLSEFNSILSG--------SLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSN--VLNDKCYTRKSAGKGANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHYRMIFTEKSCLNNLDISMNY-RQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRP-DLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGK-TIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQ-LIDL 4618
+++E L+D L C Y EC K EK+V F++ +K ++ +R+ R DF+ ++VIGRGAFG+V+VV+ K +YAMK L+K+++LK+ + ACF+EERDVL +K S WITRLHYAFQD+ +LY VMD+Y GGD+LTLLSKF DRLPE++ +FY+AE+V+++ +H+ Y+HRDIKPDN+LLD GHI LADFGSC+ + +G + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EML+GE PFY E ETY +IMN E FQ P+ DVS++A DLI++LIC +E RLG GI DFK+H FF+ IDWDN+RS AP+IP+VSS DTSNF+ DD GPP+S S F G HLP +GFTFT D F++ S +E V R++ L + + AP+ + L EE+++LK + +LE QL E T +S ++ + + L +KE + Q + +R +++ D +L +E EL+ ++ KQ D EE+ V+ + + ++ + +++ + LE +LD+ K + KE++ ++ + Q + ++Q K + + +E+ Q L +++ + N+ L++S+ +E+ L+E +K ++ D+ + LK E+S + N +L ++ V L+ +N +L LQ++S+K H+ + + V +++ L T++ E+E L++ + G R + W++R+ K D L L++E RA+ +LE KL + + + +Q+E K++V E + L +L + +++P K P S+P L E + L S T N H S TF+ P +C +C+S M+G QG C+ CSF CH C + ++ + +G +++ GIGT Y ++++PKP G+++GW+R F + D KLF +DV EG + TQ ++ V+DL+ + V V +V+HA +KD+ I K++ + + + + + VL ES K+ ++++E +S + K+ L D S+ + LSAA++D+ + GTE+GL +++T + + K V+ ++ + ++ +++AV+ + R + L G+L+GA + I + K C G P+ + AA K V+ Y + ++K ++ +V L + ++L +G A+ +L SP + D ++ Q +++ +E+ +E L+ F GI+++ R++R +L WP P + +L ++E G+ +++T + VQ + L KPL+ G + ++E A LIY S S G TI +T+ + ++ + +KRK + P + LK P L+S R IS P NF H++HMGP Q L+DL
Sbjct: 23 LSVEALLDLLVCLYTECSSCPLKREKHVTDFLQWVKPFTTAVKDMRLHRDDFEMLKVIGRGAFGEVAVVKMKNTERVYAMKILNKWEMLKRAETACFREERDVL---VKGDSQWITRLHYAFQDDNFLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYVAEMVLAVHSIHQQHYVHRDIKPDNILLDVNGHIRLADFGSCLHMMEDGMVQSSVAVGTPDYISPEILQAMEDGMGRYGPECDWWSLGVCMYEMLFGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEDARDLIQRLICSRERRLGLNGISDFKSHSFFKGIDWDNIRSMEAPYIPDVSSPTDTSNFDVDDDVLKNPDIGPPVSHSGFSGQHLPFVGFTFTTDSCFSDRCSISKAALGVLQKEGEVKGRDVEAFERRIRCLEQEKQDLNRQLQESTLALQAPSRGGTLSRDKEIKKLNEEIDRLKKKLADSDRLEHQLEEAVTLRQDYESSASKLKALERQVKALRQEKEDVHKQLSDSLERMRSLTKELKDAHSQRKLALQEYSELSERMAELRSSKQKLSRQLRDKEEEADVLLQKMDAMRLEMRKMDKNRKELEAQLDEAKAEASKERKLRENSEVYSKQLETELQGLKSQQGQGSAAAGAESQQELSRLKAELDKKVLFYEQELLQRDLSHSTEMKNMRKDLQESEGAQLAANKELLQLREKLDKAKKERQIEMDDAVAALKEKYEREKSLLTEENRKLSAETDKLCSFVDDLTAQNRQLEDDLQDLSSKKESVAHWEAQIAEIIQWVSDEKDARGYLQALATKMTEELETLRSSSL---------GSR---PLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLLQEELRKVKAANINLESKLRESEDRSREAVEQMENLKKEVEESRSHPEKSLKLQDFQDSIFEYFNTSPLAPDLTFRTSDIDPMPLKADATPSSSPSELEEGRAALGPISPSPSFYSSTITAPNPKAHQLSIKTFSSPTQCTHCSSLMVGLIRQGYACEVCSFICHVSCKDHAPLICPIPAEQAKRPQGIDVQRGIGTAYRGYVRIPKPSGVKKGWQRAFAIVSDCKLFLYDVPEGKS-TQAGVVA---SLVLDLRDEDLSVSSVMASDVIHATRKDIPCIFKVASSQLMSQLSSVSLLVLAESEAEKKKWVRMLESLQSILSKNQLKSQQV--HRLLEAYDASLPLIKTTLSAAVLDRERIALGTEDGLFVVELTRDVIVRAADCKKVHQVDLVPKE--KIIAVLCGRNRHVHLHPWGVLEGAESFFDIKLAETKGCQALCTG---------------------VLRQGGPA-----YLLAAVKRQVQCYEITRAKPHYKKHWEVQAPGTVQWLGMV--RDRLCVGYPSGFALLTLQGESSP----ISLVSPADPTLAFLAQQPLDALHALEVGSSEVLLCFSQLGIYVDGQGRRSRAQELMWPATPLACCSNSSHLTVYSEY-GVDVFDVT--TMEWVQTISLCKIKPLNVEGTLNLLSSE---APRLIYFSNAS------SAGDLTIPETTEHSRKAMVRTRSKRKFLFK------------VPEEERLQQRREMLK---DPELRS-RMISNPTNFNHVAHMGPGDGMQVLMDL 1588
BLAST of Serine/threonine kinase vs. Ensembl Medaka
Match: cdc42bpb (CDC42 binding protein kinase beta [Source:NCBI gene;Acc:101168010]) HSP 1 Score: 638.262 bits (1645), Expect = 0.000e+0 Identity = 490/1654 (29.63%), Postives = 814/1654 (49.21%), Query Frame = 2
Query: 119 VTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD--FNANHEGPPLS-SNFKGCHLPCIGFTFTKDFIFNEMGS----------EESSV----------RLKSLMEN--------------IGAPALLNGNHNESNSDALLEEVNQLKITCS---QLEKQLNECRT------NSVQRIFS-HPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQ-------DIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKC----------------------SNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQ-------VKSLSEENVELRSSLQEISNKNMKF-HFRLKTILDKEIVKTSENSE-----LLTELDREVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARA--------------DLEKKLTQQKSEICDISKQLEKYKQDVNEKDN-----------------------LIANLKSASQNLEP------HVPKEIPS----------NPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSN--VLNDKCYTRKSAGKGANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKIS---IENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHYRMIFTEKSCLNNLDISMNY-RQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRP-DLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGK-TIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQ-LIDL 4618
+++E L+D L C Y EC K EK+V F++ +K ++ +R+ R DF+ ++VIGRGAFG+V+VV+ K +YAMK L+K+++LK+ + ACF+EERDVL +K S WITRLHYAFQD+ +LY VMD+Y GGD+LTLLSKF DRLPE++ +FY+AE+V+++ +H+ Y+HRDIKPDN+LLD GHI LADFGSC+ + +G + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EML+GE PFY E ETY +IMN E FQ P+ DVS++A DLI++LIC +E RLG GI DFK+H FF+ IDWDN+RS AP+IP+VSS DTSNF+ DD GPP+S S F G HLP +GFTFT D F++ S +E V R++ L + + AP+ + L EE+++LK + +LE QL E T +S ++ + + L +KE + Q + +R +++ D +L +E EL+ ++ KQ D EE+ V+ + + ++ + +++ + LE +LD+ K + KE++ ++ + Q + ++Q K + + +E+ Q L +++ + N+ L++S+ +E+ L+E +K ++ D+ + LK E+S + N +L ++ V L+ +N +L LQ++S+K H+ + + V +++ L T++ E+E L++ + G R + W++R+ K D L L++E RA+ +LE KL + + + +Q+E K++V E + L +L + +++P P PS P++ S S S ++ T N H S TF+ P +C +C+S M+G QG C+ CSF CH C + ++ + +G +++ GIGT Y ++++PKP G+++GW+R F + D KLF +DV EG + TQ ++ V+DL+ + V V +V+HA +KD+ I K++ + + + + + VL ES K+ ++++E +S + K+ L D S+ + LSAA++D+ + GTE+GL +++T + + K V+ ++ + ++ +++AV+ + R + L G+L+GA + I + K C G P+ + AA K V+ Y + ++K ++ +V L + ++L +G A+ +L SP + D ++ Q +++ +E+ +E L+ F GI+++ R++R +L WP P + +L ++E G+ +++T + VQ + L KPL+ G + ++E A LIY S S G TI +T+ + ++ + +KRK + P + LK P L+S R IS P NF H++HMGP Q L+DL
Sbjct: 23 LSVEALLDLLVCLYTECSSCPLKREKHVTDFLQWVKPFTTAVKDMRLHRDDFEMLKVIGRGAFGEVAVVKMKNTERVYAMKILNKWEMLKRAETACFREERDVL---VKGDSQWITRLHYAFQDDNFLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYVAEMVLAVHSIHQQHYVHRDIKPDNILLDVNGHIRLADFGSCLHMMEDGMVQSSVAVGTPDYISPEILQAMEDGMGRYGPECDWWSLGVCMYEMLFGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEDARDLIQRLICSRERRLGLNGISDFKSHSFFKGIDWDNIRSMEAPYIPDVSSPTDTSNFDVDDDVLKNPDIGPPVSHSGFSGQHLPFVGFTFTTDSCFSDRCSISKAALGVLQKEGEVKGRDVEAFERRIRCLEQEKQDLNRQLQESTLALQAPSRGGTLSRDKEIKKLNEEIDRLKKKLADSDRLEHQLEEAVTLRQDYESSASKLKALERQVKALRQEKEDVHKQLSDSLERMRSLTKELKDAHSQRKLALQEYSELSERMAELRSSKQKLSRQLRDKEEEADVLLQKMDAMRLEMRKMDKNRKELEAQLDEAKAEASKERKLRENSEVYSKQLETELQGLKSQQGQGSAAAGAESQQELSRLKAELDKKVLFYEQELLQRDLSHSTEMKNMRKDLQESEGAQLAANKELLQLREKLDKAKKERQIEMDDAVAALKEKYEREKSLLTEENRKLSAETDKLCSFVDDLTAQNRQLEDDLQDLSSKKESVAHWEAQIAEIIQWVSDEKDARGYLQALATKMTEELETLRSSSL---------GSR---PLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLLQEELRKVKAANINLESKLRESEDRSREAVEQMENLKKEVEESRSHPEKSLKLQDFQDSIFEYFNTSPLAPDLTFRTSDIDPMPLKADATPSSSPSELEQEGRAALGPISPS--PSFYSSTI--TAPNPKAHQLSIKTFSSPTQCTHCSSLMVGLIRQGYACEVCSFICHVSCKDHAPLICPIPAEQAKRPQGIDVQRGIGTAYRGYVRIPKPSGVKKGWQRAFAIVSDCKLFLYDVPEGKS-TQAGVVA---SLVLDLRDEDLSVSSVMASDVIHATRKDIPCIFKVASSQLMSQLSSVSLLVLAESEAEKKKWVRMLESLQSILSKNQLKSQQV--HRLLEAYDASLPLIKTTLSAAVLDRERIALGTEDGLFVVELTRDVIVRAADCKKVHQVDLVPKE--KIIAVLCGRNRHVHLHPWGVLEGAESFFDIKLAETKGCQALCTG---------------------VLRQGGPA-----YLLAAVKRQVQCYEITRAKPHYKKHWEVQAPGTVQWLGMV--RDRLCVGYPSGFALLTLQGESSP----ISLVSPADPTLAFLAQQPLDALHALEVGSSEVLLCFSQLGIYVDGQGRRSRAQELMWPATPLACCSNSSHLTVYSEY-GVDVFDVT--TMEWVQTISLCKIKPLNVEGTLNLLSSE---APRLIYFSNAS------SAGDLTIPETTEHSRKAMVRTRSKRKFLFK------------VPEEERLQQRREMLK---DPELRS-RMISNPTNFNHVAHMGPGDGMQVLMDL 1589
BLAST of Serine/threonine kinase vs. Ensembl Medaka
Match: cdc42bpab (CDC42 binding protein kinase alpha [Source:NCBI gene;Acc:101159789]) HSP 1 Score: 473.011 bits (1216), Expect = 9.632e-138 Identity = 287/775 (37.03%), Postives = 445/775 (57.42%), Query Frame = 2
Query: 119 VTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPA--LLNGNHNESNSDALLEE-----VNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREK--------EQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXX---XXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLR------SENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNK-------EKNLKLSH-DNEIEQLKISVAEEQSRILASN-TQLKSQVKSLSEENVELRSSLQEISNKNMKF-HFRLKTILDKE--------------IVKTSENSELLTELDR 2287
+++E L+D L C Y EC + EKN+ +F+ K K++ +R+ + DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL WIT LHYAFQD+ LY VMD+Y GGD+LTLLSKF DRLPE++ KFY+AE+V++ID VH+L Y+HRDIKPDN+LLD GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ P + DVS+EA+DLI++LIC +E RLG GI+DFK HPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N+ PP + F G HLP +GFT+T F++ G L+ L G ++ + D+L E + +L+ ++L ++L+E T +VQ HP + ++ +++ + + + +K E+K++D+ + R L + + Q+ Q+ +E K + E ++LKS +K + + + +L + + L+ Q + +++ + Q+ E + L++R E + + E+ + E+++Q ++EE++ LK + ++ ++ H E+E+ + EE +R A + T+LK+ K L + + + +EI K R ++I+D+E ++ T EN +L +LD+
Sbjct: 26 LSVETLLDILVCLYDECNNSPLRREKNILEFLDWAKPFTSKVKQMRLHKEDFEILKVIGRGAFGEVAVVKVKNTDKVFAMKILNKWEMLKRAETACFREERDVLVNG---DCQWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMAKFYLAEMVLAIDSVHQLHYVHRDIKPDNILLDKKGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPQQLTDVSEEAKDLIRRLICSREHRLGQNGIEDFKQHPFFSGIDWDNIRTCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPSHTAFSGHHLPFVGFTYTSKCTFSDRGC------LRQLSGERGQTGEDQVDLDVKRRLEDSLATEAYERRIRRLEQEKTELSRKLHES-TQTVQ-ALQHPTTESPLSSTKEVEIRSLKTEIEILKKQIAESGQLEKKLEDVTSSRRDLEDSSKHVRTLEKQLKSLTQERDEMQKDLVEASDRLKSQSKELKEAHSQRKLAMQEFSELNSTLTDLRSAKQRLARQLRDKEEEMETQSQKVEALRLEVRKAERAKKEVEVLAEEHAAEAQKEKKIRERNEQYSRQLEEELEGLKSKQSGSSVTPAAADQTQEVGHLRGEMERKTLLYEEELARREAQHSTELKTLRKELRDAESQQLTLQKEILMLKDKLDQARRRSIIDREEIEMEYKQKYETERVLLTEENKKLSNDLDK 789 HSP 2 Score: 232.646 bits (592), Expect = 6.233e-61 Identity = 183/694 (26.37%), Postives = 316/694 (45.53%), Query Frame = 2
Query: 2579 SASQNLEP-----HVPKEIPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGKGA---NLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIEN----SSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDP-HYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFIN-RNHRQTRPDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
S + ++EP H P+ + + + + GS+ + H F +F+ P KC+ CTS M+G QG C+ C+FSCH C ++ C + KG+ + + GIGT YE +++VPKP G+++GW+R +CD KLF +++ EG +S +VID++ EF V V +V+HA +KD+ I +++ + SS I +L +S + + ++ E +KK+ R ++ K ++ + Q SAAIID + G EEGL + VT ++G+ K VY I+ + Q+ L+AVI K R ++L+ LDG +VE K C G N + +C A K + Y +N + +LR + ++ + + G++L +G YS+ + + + L D +I Q N E++ VEIS E L+ F G++++ HR + +L WP P Y APYL ++E A + +++ ++ +Q +PL+ +PL+ G + ++ + LIY A +++ + +T D++ S + NK+ SF P + RD P ++ N+ IS P NF H++HMGP Q++
Sbjct: 1016 SMASDMEPIELIDHQPRSVQTPTMRSGGY-----GSMGRCSPKPKAHQFVVKSFSAPTKCNQCTSLMVGLIRQGCMCEVCNFSCHVTC-ADKAPAVCPVPQDQTKGSLGIDPQRGIGTAYEGYVRVPKPTGVKKGWQRAMAVVCDFKLFLYELGEGKAAQPSVIVS----QVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASHLSASSSQKTSILMLADSDQERNKWVGLLGELHRILKKNKLKDRFVYVPKEAYDSTLPLIKGTQ--SAAIIDHERVALGNEEGLFVIHVTKDEIIRVGDNKKVYQIDPIPQE--HLLAVISGKNRHVRLVPIMALDGRETDCQKLVET-KGCQRIASGPV--------------------------RNGSLMCLCVAMKTKIICYEVNRSKAHYRRLRDVQAPAAIQWMGL--FGDRLYVGYQSGFVRYSIPDN----MAMVSLLHPEDHTLAFIPQQNLEALCAVEISSKELLLCFSSIGVYVDSHGHRSRQQELMWPATPNAACYNAPYLSVYSENA-VDVFDV--NTMEWIQTIPLKKVRPLNVDGSLNLLG---LETVRLIYFRNKMAEGDELVVPETSDQSRKQMVRS----------NNNKRRFSFRV-------PEEERLQQRREMLRD-PEMR-NKLISNPTNFNHVAHMGPGDGIQIL 1637
BLAST of Serine/threonine kinase vs. Ensembl Medaka
Match: cdc42bpab (CDC42 binding protein kinase alpha [Source:NCBI gene;Acc:101159789]) HSP 1 Score: 473.011 bits (1216), Expect = 1.069e-137 Identity = 287/775 (37.03%), Postives = 445/775 (57.42%), Query Frame = 2
Query: 119 VTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAE-GHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDD---FNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPA--LLNGNHNESNSDALLEE-----VNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREK--------EQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXX---XXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLR------SENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNK-------EKNLKLSH-DNEIEQLKISVAEEQSRILASN-TQLKSQVKSLSEENVELRSSLQEISNKNMKF-HFRLKTILDKE--------------IVKTSENSELLTELDR 2287
+++E L+D L C Y EC + EKN+ +F+ K K++ +R+ + DF+ ++VIGRGAFG+V+VV+ K +++AMK L+K+++LK+ + ACF+EERDVL WIT LHYAFQD+ LY VMD+Y GGD+LTLLSKF DRLPE++ KFY+AE+V++ID VH+L Y+HRDIKPDN+LLD GHI LADFGSC+KL +GT + AVGTPDYISPEIL++ E G G YG ECDWWSLG+ ++EMLYGE PFY E ETY +IMN + FQ P + DVS+EA+DLI++LIC +E RLG GI+DFK HPFF IDWDN+R+ AP+IPEVSS DTSNF+ DD N+ PP + F G HLP +GFT+T F++ G L+ L G ++ + D+L E + +L+ ++L ++L+E T +VQ HP + ++ +++ + + + +K E+K++D+ + R L + + Q+ Q+ +E K + E ++LKS +K + + + +L + + L+ Q + +++ + Q+ E + L++R E + + E+ + E+++Q ++EE++ LK + ++ ++ H E+E+ + EE +R A + T+LK+ K L + + + +EI K R ++I+D+E ++ T EN +L +LD+
Sbjct: 26 LSVETLLDILVCLYDECNNSPLRREKNILEFLDWAKPFTSKVKQMRLHKEDFEILKVIGRGAFGEVAVVKVKNTDKVFAMKILNKWEMLKRAETACFREERDVLVNG---DCQWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMAKFYLAEMVLAIDSVHQLHYVHRDIKPDNILLDKKGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPQQLTDVSEEAKDLIRRLICSREHRLGQNGIEDFKQHPFFSGIDWDNIRTCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPSHTAFSGHHLPFVGFTYTSKCTFSDRGC------LRQLSGERGQTGEDQVDLDVKRRLEDSLATEAYERRIRRLEQEKTELSRKLHES-TQTVQ-ALQHPTTESPLSSTKEVEIRSLKTEIEILKKQIAESGQLEKKLEDVTSSRRDLEDSSKHVRTLEKQLKSLTQERDEMQKDLVEASDRLKSQSKELKEAHSQRKLAMQEFSELNSTLTDLRSAKQRLARQLRDKEEEMETQSQKVEALRLEVRKAERAKKEVEVLAEEHAAEAQKEKKIRERNEQYSRQLEEELEGLKSKQSGSSVTPAAADQTQEVGHLRGEMERKTLLYEEELARREAQHSTELKTLRKELRDAESQQLTLQKEILMLKDKLDQARRRSIIDREEIEMEYKQKYETERVLLTEENKKLSNDLDK 789 HSP 2 Score: 232.646 bits (592), Expect = 7.152e-61 Identity = 183/694 (26.37%), Postives = 316/694 (45.53%), Query Frame = 2
Query: 2579 SASQNLEP-----HVPKEIPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGKGA---NLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIEN----SSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDP-HYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGL--LKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFIN-RNHRQTRPDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLI 4612
S + ++EP H P+ + + + + GS+ + H F +F+ P KC+ CTS M+G QG C+ C+FSCH C ++ C + KG+ + + GIGT YE +++VPKP G+++GW+R +CD KLF +++ EG +S +VID++ EF V V +V+HA +KD+ I +++ + SS I +L +S + + ++ E +KK+ R ++ K ++ + Q SAAIID + G EEGL + VT ++G+ K VY I+ + Q+ L+AVI K R ++L+ LDG +VE K C G N + +C A K + Y +N + +LR + ++ + + G++L +G YS+ + + + L D +I Q N E++ VEIS E L+ F G++++ HR + +L WP P Y APYL ++E A + +++ ++ +Q +PL+ +PL+ G + ++ + LIY A +++ + +T D++ S + NK+ SF P + RD P ++ N+ IS P NF H++HMGP Q++
Sbjct: 1003 SMASDMEPIELIDHQPRSVQTPTMRSGGY-----GSMGRCSPKPKAHQFVVKSFSAPTKCNQCTSLMVGLIRQGCMCEVCNFSCHVTC-ADKAPAVCPVPQDQTKGSLGIDPQRGIGTAYEGYVRVPKPTGVKKGWQRAMAVVCDFKLFLYELGEGKAAQPSVIVS----QVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASHLSASSSQKTSILMLADSDQERNKWVGLLGELHRILKKNKLKDRFVYVPKEAYDSTLPLIKGTQ--SAAIIDHERVALGNEEGLFVIHVTKDEIIRVGDNKKVYQIDPIPQE--HLLAVISGKNRHVRLVPIMALDGRETDCQKLVET-KGCQRIASGPV--------------------------RNGSLMCLCVAMKTKIICYEVNRSKAHYRRLRDVQAPAAIQWMGL--FGDRLYVGYQSGFVRYSIPDN----MAMVSLLHPEDHTLAFIPQQNLEALCAVEISSKELLLCFSSIGVYVDSHGHRSRQQELMWPATPNAACYNAPYLSVYSENA-VDVFDV--NTMEWIQTIPLKKVRPLNVDGSLNLLG---LETVRLIYFRNKMAEGDELVVPETSDQSRKQMVRS----------NNNKRRFSFRV-------PEEERLQQRREMLRD-PEMR-NKLISNPTNFNHVAHMGPGDGIQIL 1624
BLAST of Serine/threonine kinase vs. Planmine SMEST
Match: SMESG000049701.1 (SMESG000049701.1) HSP 1 Score: 3165.17 bits (8205), Expect = 0.000e+0 Identity = 1637/1641 (99.76%), Postives = 1640/1641 (99.94%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIANLKSASQNLEPHVPKEIPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGKGANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGLLKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRPDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLIDLXXXXXXXXXXXXXXIYLKDVRAQVNQLELDSNSIMTKXXXXXXXXXXXXXXXXXXGRXXXXXXXXXXXXXXXXXXXXXXXXXXXXEQIMADFQLIQSSTINCTPGRSTNANN 4954
MSIKLTLKQRHENLIKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREKEQK+DDLIETNRLLNK+RDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINREKDLLEFELDKLKKQWMKEKEEMKHLS QKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIANLKSASQNLEPHVPKEIPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLS+VLNDKCYTRKSAGKGANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGLLKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPLLLIHKDLKDIDINFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRPDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLIDLKPKESMKMSDKEKSIYLKDVRAQVNQLELDSNSIMTKSNISQTSQSSMSQALSHSGRSSPSQSVTIPASSSASSDLFLSTSPSFSEQIMADFQLIQSSTINCTPGRSTNANN
Sbjct: 1 MSIKLTLKQRHENLIKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREKEQKIDDLIETNRLLNKDRDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINREKDLLEFELDKLKKQWMKEKEEMKHLSTQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIANLKSASQNLEPHVPKEIPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSHVLNDKCYTRKSAGKGANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGLLKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPLLLIHKDLKDIDINFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRPDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLIDLKPKESMKMSDKEKSIYLKDVRAQVNQLELDSNSIMTKSNISQTSQSSMSQALSHSGRSSPSQSVTIPASSSASSDLFLSTSPSFSEQIMADFQLIQSSTINCTPGRSTNANN 1641
BLAST of Serine/threonine kinase vs. Planmine SMEST
Match: SMESG000049701.1 (SMESG000049701.1) HSP 1 Score: 3147.84 bits (8160), Expect = 0.000e+0 Identity = 1632/1641 (99.45%), Postives = 1635/1641 (99.63%), Query Frame = 2
Query: 32 MSIKLTLKQRHENLIKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREKEQKMDDLIETNRLLNKERDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINRXXXXXXXXXXXXXXXXXXXXXXXXHLSIQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIANLKSASQNLEPHVPKEIPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSNVLNDKCYTRKSAGKGANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGLLKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPXXXXXXXXXXXXXNFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRPDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLIDLXXXXXXXXXXXXXXIYLKDVRAQVNQLELDSNSIMTKXXXXXXXXXXXXXXXXXXGRXXXXXXXXXXXXXXXXXXXXXXXXXXXXEQIMADFQLIQSSTINCTPGRSTNANN 4954
MSIKLTLKQRHENLIKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREKEQK+DDLIETNRLLNK+RDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINREKDLLEFELDKLKKQWMKEKEEMKHLS QKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIANLKSASQNLEP IPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLS+VLNDKCYTRKSAGKGANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGLLKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPLLLIHKDLKDIDINFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRPDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLIDLKPKESMKMSDKEKSIYLKDVRAQVNQLELDSNSIMTKSNISQTSQSSMSQALSHSGRSSPSQSVTIPASSSASSDLFLSTSPSFSEQIMADFQLIQSSTINCTPGRSTNANN
Sbjct: 1 MSIKLTLKQRHENLIKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNKGIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDFNANHEGPPLSSNFKGCHLPCIGFTFTKDFIFNEMGSEESSVRLKSLMENIGAPALLNGNHNESNSDALLEEVNQLKITCSQLEKQLNECRTNSVQRIFSHPVYQQLVTDKEKLLTQCQNYDYSLREKEQKIDDLIETNRLLNKDRDELTSDRLQILQKKQDIEEDLKVMTENFNQLKSTNKAINREKDLLEFELDKLKKQWMKEKEEMKHLSTQKNQSQPDIQVEKQRFEEVMLQLRSENDQMLEKMRLKCSNLTNSLEQSDQTIFNIKEEIKSLKEIFTNKEKNLKLSHDNEIEQLKISVAEEQSRILASNTQLKSQVKSLSEENVELRSSLQEISNKNMKFHFRLKTILDKEIVKTSENSELLTELDREVELLKTLCVDNDGDQKAQGERQDNNGNESWRLRKCVKADKIEISNLNLTLQSERRARADLEKKLTQQKSEICDISKQLEKYKQDVNEKDNLIANLKSASQNLEP-----IPSNPVTLSEFNSILSGSLDKTVVNCNQHVFSHSTFNRPIKCDYCTSHMLGQYYQGVKCKECSFSCHHYCLSHVLNDKCYTRKSAGKGANLKNGIGTMYENFIKVPKPGGIRRGWKRQFMALCDLKLFFFDVKEGSTGTQMPDISRNPCRVIDLKYTEFKVVKVSRDEVMHAPKKDVEFIIKISIENSSTMLPIYVLFESVDNKEDCIKVIEEARSYIKKDPHYRMIFTEKSCLNNLDISMNYRQILSAAIIDQSTLLFGTEEGLLKVTDSGYNKIGEKKPVYIIESLDQQELQLVAVIQSKQRVLKLLLSGILDGAHDWEPIIVENGKSCTTFVVGKSYVSPGNQFAPYADTMLANSTFHIKSPSNDRIWIMCAAFKNSVEVYHLNLKLTRHEKLRQILCNTSVTSLQIAGHGEQLLIGMHDSVAIYSLWETGSPLLLIHKDLKDIDINFQYIFQTNFESMLIVEISFNEYLILFECAGIFINRNHRQTRPDLQWPDKPTRFTYRAPYLLCFTEMAGLFAYEITEHSCNLVQALPLRSSKPLDRSGHILTTANEFIQAIDLIYVHLVSANEEKISIGKTIDKTSSSNTLSIFKFLNKRKPSYNKQEDSFDTNDAISPNPAGNSTKSTGLKYRDKPTLKSNRQISVPQNFRHLSHMGPDVPCQLIDLKPKESMKMSDKEKSIYLKDVRAQVNQLELDSNSIMTKSNISQTSQSSMSQALSHSGRSSPSQSVTIPASSSASSDLFLSTSPSFSEQIMADFQLIQSSTINCTPGRSTNANN 1636
BLAST of Serine/threonine kinase vs. Planmine SMEST
Match: SMESG000041847.1 (SMESG000041847.1) HSP 1 Score: 315.849 bits (808), Expect = 6.562e-88 Identity = 168/409 (41.08%), Postives = 255/409 (62.35%), Query Frame = 2
Query: 92 NYKSSVPD---SVTLEFLIDSLFCTYYECR----LPFHKDEKNVAQFIKSIKGTVDKIESLRIRRSDFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTTIT-ERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLG-NKGIDDFKNHPFF----REIDWDNLRSYNAPFIPEVSSAEDTSNFEF--DDFNAN-----HEGPPLSSNFKGCHLPCIGFTFTK 1258
N+++ V D +++L+ L DS + +C+ LP +K N F K K +K+ R++ SDF+ +++IG+GAFG+V +VR K+ G+++A+K L+K ++ +QEERD++ MKI S WI +LHYAFQD LY VMD+ GG+++ +SK L +++ FY AE+V++I+ +H G++HRDIKPDN+L+D GHI LADFGSCVK+ P + RA+GTPDYISPE+L S + YG E DWW+LG++++E+ YGE PFY+++ TY +IM E P + D+VS A D +K+LIC + RLG K D K+H FF RE WD ++ +PFIP + + DTS F+F DD + N ++G S+ F G ++ GF++ +
Sbjct: 13 NFQNVVSDDKENISLDLLFDSFQNLFLDCKSVSNLPTNKYFTN---FYKQHKKVYEKLVDFRMKYSDFNLLKIIGQGAFGQVQLVRHKQTGDLFALKILNKSQVVTCEGTLFWQEERDIM---MKIDSRWIVKLHYAFQDPKRLYMVMDYLPGGNLVNWMSKVEVLLEKDVC-FYAAEIVLAINGLHNFGFVHRDIKPDNILIDIKGHIKLADFGSCVKMDPVTKYVNCNRAIGTPDYISPEVLLSQSDNTKYGKEVDWWALGVMLYEIFYGEPPFYSDNLINTYGKIMTHEQSLSFPPD-DEVSGMALDFMKKLICDRSVRLGQTKDASDIKSHIFFNNSSREWTWDTIQDSTSPFIPVLENDLDTSYFDFGEDDVDTNFLNQSNQGLK-STTFIGENIQFSGFSYIR 412
BLAST of Serine/threonine kinase vs. Planmine SMEST
Match: SMESG000015619.1 (SMESG000015619.1) HSP 1 Score: 267.7 bits (683), Expect = 3.402e-78 Identity = 145/355 (40.85%), Postives = 212/355 (59.72%), Query Frame = 2
Query: 230 TVDKIESLRIRRS-----DFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTT---------------------------------ITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNK-GIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDF 1177
T+ + E LR++R+ DF ++VIGRGAFG+V++V+ K+ G IYAMK L K ++++K A + ERD+L K+ +PW+ ++ Y+FQD +LY VM+F GGD++ LL K D EE T+FYI+E +++ID +HKLG++HRDIKPDNLLLDS GHI L+DFG C L+ + T + VGTPDYI+PE+ + Y CDWWSLG+++ EML G PF +E ETY +++++ P E +S +A +I L C+ E RLG+K G+DDF++ FF+ IDW+++R A ++ S +D SN FDDF
Sbjct: 102 TLKESEYLRLKRAKLNFNDFQIVKVIGRGAFGEVALVQKKDNGYIYAMKILRKCNMIEKDQIAHVRAERDIL---TKVNNPWVVKMFYSFQDSHFLYLVMEFLPGGDLMNLLIKM-DTFTEEQTQFYISETILAIDSIHKLGFIHRDIKPDNLLLDSKGHIKLSDFGLCTGLKKSHRTEFYKDLSKAKPCDFTNSIQSKKKVESWKKTRRKLAYSTVGTPDYIAPEVFQRI----GYTNACDWWSLGVIMFEMLIGYPPFCSESPGETYLKVISWRESLIFPAEM-PISSQACSVINLLCCEHENRLGSKHGVDDFRSLEFFKNIDWEHIRERPAAIHVKIRSIDDVSN--FDDF 445
BLAST of Serine/threonine kinase vs. Planmine SMEST
Match: SMESG000015619.1 (SMESG000015619.1) HSP 1 Score: 267.314 bits (682), Expect = 6.023e-78 Identity = 145/355 (40.85%), Postives = 212/355 (59.72%), Query Frame = 2
Query: 230 TVDKIESLRIRRS-----DFDTIRVIGRGAFGKVSVVRFKEKGEIYAMKSLHKYDILKKIDAACFQEERDVLFQAMKIKSPWITRLHYAFQDEFYLYFVMDFYNGGDMLTLLSKFNDRLPEEITKFYIAEVVMSIDVVHKLGYLHRDIKPDNLLLDSLGHIVLADFGSCVKLRPNGTT---------------------------------ITERAVGTPDYISPEILRSAEGHGPYGVECDWWSLGIVIHEMLYGELPFYNEDFSETYWQIMNFETCFQIPTEYDDVSDEAEDLIKQLICKKECRLGNK-GIDDFKNHPFFREIDWDNLRSYNAPFIPEVSSAEDTSNFEFDDF 1177
T+ + E LR++R+ DF ++VIGRGAFG+V++V+ K+ G IYAMK L K ++++K A + ERD+L K+ +PW+ ++ Y+FQD +LY VM+F GGD++ LL K D EE T+FYI+E +++ID +HKLG++HRDIKPDNLLLDS GHI L+DFG C L+ + T + VGTPDYI+PE+ + Y CDWWSLG+++ EML G PF +E ETY +++++ P E +S +A +I L C+ E RLG+K G+DDF++ FF+ IDW+++R A ++ S +D SN FDDF
Sbjct: 106 TLKESEYLRLKRAKLNFNDFQIVKVIGRGAFGEVALVQKKDNGYIYAMKILRKCNMIEKDQIAHVRAERDIL---TKVNNPWVVKMFYSFQDSHFLYLVMEFLPGGDLMNLLIKM-DTFTEEQTQFYISETILAIDSIHKLGFIHRDIKPDNLLLDSKGHIKLSDFGLCTGLKKSHRTEFYKDLSKAKPCDFTNSIQSKKKVESWKKTRRKLAYSTVGTPDYIAPEVFQRI----GYTNACDWWSLGVIMFEMLIGYPPFCSESPGETYLKVISWRESLIFPAEM-PISSQACSVINLLCCEHENRLGSKHGVDDFRSLEFFKNIDWEHIRERPAAIHVKIRSIDDVSN--FDDF 449 The following BLAST results are available for this feature:
BLAST of Serine/threonine kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Serine/threonine kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Serine/threonine kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Serine/threonine kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30024442 ID=SMED30024442|Name=Serine/threonine kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=5530bpback to top protein sequence of SMED30024442-orf-1 >SMED30024442-orf-1 ID=SMED30024442-orf-1|Name=SMED30024442-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1642bp MSIKLTLKQRHENLIKEFLLNYKSSVPDSVTLEFLIDSLFCTYYECRLPFback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|
