Potassium channel tetramerization domain containing 1
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30024416 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 10
Homology
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Human
Match: CRKL (CRK like proto-oncogene, adaptor protein [Source:HGNC Symbol;Acc:HGNC:2363]) HSP 1 Score: 75.485 bits (184), Expect = 7.601e-15 Identity = 70/284 (24.65%), Postives = 118/284 (41.55%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKD-GWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPK---------------------PFYRVLQTYHPKSDIE-LAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPV----NILKQSSNDK-----------TSLQQMVFKMQSRVPFKTL----------------------AIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WY G +SR EAQ + + G +L+RD + G YVL V E ++ + YII+ + +KIG+ EFD + +LL + + +TL PAP+ + R L + P +D E L + + + + K +E+ +G +PV +++ S + K + Q+ P + AI+ R P +DK+ L+++VGD + V + NG + + G+ GL PF V I D Sbjct: 14 WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDF-PGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVN-GRKGLFPFTHVKIFD 295
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Human
Match: CRKL (CRK like proto-oncogene, adaptor protein [Source:HGNC Symbol;Acc:HGNC:2363]) HSP 1 Score: 75.485 bits (184), Expect = 7.601e-15 Identity = 70/284 (24.65%), Postives = 118/284 (41.55%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKD-GWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPK---------------------PFYRVLQTYHPKSDIE-LAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPV----NILKQSSNDK-----------TSLQQMVFKMQSRVPFKTL----------------------AIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WY G +SR EAQ + + G +L+RD + G YVL V E ++ + YII+ + +KIG+ EFD + +LL + + +TL PAP+ + R L + P +D E L + + + + K +E+ +G +PV +++ S + K + Q+ P + AI+ R P +DK+ L+++VGD + V + NG + + G+ GL PF V I D Sbjct: 14 WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDF-PGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVN-GRKGLFPFTHVKIFD 295
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Human
Match: CRK (CRK proto-oncogene, adaptor protein [Source:HGNC Symbol;Acc:HGNC:2362]) HSP 1 Score: 64.6994 bits (156), Expect = 3.427e-11 Identity = 64/286 (22.38%), Postives = 111/286 (38.81%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYII--------------------SPYKDGWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKP--------------FYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQSSNDKTSLQQMVFKMQS----------------------------RVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WY+G LSR EA + + G +L+RD + G YVL V E ++ + YII SP + +IG+ EFDS+ +LL + + +TL P + + R L ++ + +L + +R K +E+ G +PV +++ S+ ++ Q P I+ R PN +DK+ L+++VG+ + V + +G + + GK G PF V + D Sbjct: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSR--LRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECN-GKRGHFPFTHVRLLD 295
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Human
Match: CRK (CRK proto-oncogene, adaptor protein [Source:HGNC Symbol;Acc:HGNC:2362]) HSP 1 Score: 53.9138 bits (128), Expect = 6.876e-8 Identity = 40/151 (26.49%), Postives = 64/151 (42.38%), Query Frame = 2 Query: 176 NLMQNHVKDWYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYII--------------------SPYKDGWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQTYHPKSDIELAVNECQFVRFVLKYD 568 N WY+G LSR EA + + G +L+RD + G YVL V E ++ + YII SP + +IG+ EFDS+ +LL + + +TL P + S + L E ++VR + ++ Sbjct: 4 NFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSR--LRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRS--------RQGSGVILRQEEAEYVRALFDFN 144
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Human
Match: CRK (CRK proto-oncogene, adaptor protein [Source:HGNC Symbol;Acc:HGNC:2362]) HSP 1 Score: 52.7582 bits (125), Expect = 2.161e-7 Identity = 34/110 (30.91%), Postives = 52/110 (47.27%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYII--------------------SPYKDGWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPK 472 WY+G LSR EA + + G +L+RD + G YVL V E ++ + YII SP + +IG+ EFDS+ +LL + + +TL P + Sbjct: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSR--LRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR 120
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Celegans
Match: ced-2 (Cell death abnormality protein 2 [Source:UniProtKB/Swiss-Prot;Acc:Q9NHC3]) HSP 1 Score: 73.1738 bits (178), Expect = 1.552e-14 Identity = 67/260 (25.77%), Postives = 116/260 (44.62%), Query Frame = 2 Query: 197 KDWYFGNLSRDEAQNSIFMEAD---GTYLIRDCNQILGGYVLLVKEKTQTNK---YIIS---PYKDGW-----KIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQ---TYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILK---QSSNDKTSLQQMV----------------------FKMQSRVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVP 850 + +YF +SR+EA + + E GT+L+RD ++ G Y L V+E + N Y+I P +DG KI N F I +LL+HF ++ +++L KP V+ + + + +L + + + + K ++ G +P N ++ + ND+TS ++Q R+P K DR PN +D +QL VK G +++V + NGM + + G+ G VP Sbjct: 12 RSFYFPGMSREEA-HKLLGEPQVSIGTFLMRDSSRP-GEYSLTVREADEGNAVCHYLIERGEPKEDGTAAAGVKIANQSFPDIPALLNHFKMRVLTEASLLAAYKKPIIEVVVGTFKFTGERETDLPFEQGERLEILSKTNQDWWEARNALGTTGLVPANYVQIQMEFHNDRTSKGASQSSIGSSGGGAERFSSASTSSDNIELQPRLPAKAKVTFDRVPNAYDPTQLRVKKGQTVLVTQKMSNGMYKAELD-GQIGSVP 268
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Celegans
Match: nck-1 (NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family [Source:UniProtKB/TrEMBL;Acc:Q95PX0]) HSP 1 Score: 46.9802 bits (110), Expect = 8.235e-6 Identity = 30/96 (31.25%), Postives = 49/96 (51.04%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDG-WKIGNTEFDSIESLLSHFSKVIIRQST-----LTNPAPK 472 WYFG +SR+ A++ + +G +L+RD G + ++ + NK+ DG KIGN F + +L++H++ I S LT P PK Sbjct: 192 WYFGRISRERAEDLLLHGREGEFLVRDSESNPGDLSISMR-GIERNKHFKVQNVDGLLKIGNRTFVDMNALINHYTTSPIFSSPTEKLFLTGPLPK 286
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Celegans
Match: nck-1 (NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family [Source:UniProtKB/TrEMBL;Acc:Q95PX0]) HSP 1 Score: 46.9802 bits (110), Expect = 8.235e-6 Identity = 30/96 (31.25%), Postives = 49/96 (51.04%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDG-WKIGNTEFDSIESLLSHFSKVIIRQST-----LTNPAPK 472 WYFG +SR+ A++ + +G +L+RD G + ++ + NK+ DG KIGN F + +L++H++ I S LT P PK Sbjct: 192 WYFGRISRERAEDLLLHGREGEFLVRDSESNPGDLSISMR-GIERNKHFKVQNVDGLLKIGNRTFVDMNALINHYTTSPIFSSPTEKLFLTGPLPK 286
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Celegans
Match: nck-1 (NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family [Source:UniProtKB/TrEMBL;Acc:Q95PX0]) HSP 1 Score: 46.9802 bits (110), Expect = 8.235e-6 Identity = 30/96 (31.25%), Postives = 49/96 (51.04%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDG-WKIGNTEFDSIESLLSHFSKVIIRQST-----LTNPAPK 472 WYFG +SR+ A++ + +G +L+RD G + ++ + NK+ DG KIGN F + +L++H++ I S LT P PK Sbjct: 192 WYFGRISRERAEDLLLHGREGEFLVRDSESNPGDLSISMR-GIERNKHFKVQNVDGLLKIGNRTFVDMNALINHYTTSPIFSSPTEKLFLTGPLPK 286
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Fly
Match: Crk (gene:FBgn0024811 transcript:FBtr0089113) HSP 1 Score: 83.5741 bits (205), Expect = 3.476e-18 Identity = 66/249 (26.51%), Postives = 116/249 (46.59%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEAD-GTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDG----WKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQTYH--PKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQSSN-------DKT----SLQQMVFK-------MQSRVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WYFG +SR +A + E + G +L+RD N I G YVL V+E T+ + YII+ + ++IG+ FD++ LL+ ++ + + L PA + +V+ + +L + + V K +++ + IG +PV ++Q + DK S VF+ + ++P + R PN +DK+ L +++GD + V NG + + GK+G PF V D Sbjct: 12 WYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQDQIVYRIGDQSFDNLPKLLTFYTLHYLDTTPLKRPACRRVEKVIGKFDFVGSDQDDLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQQYDDYMDEDAIDKNEPSISGSSNVFESTLKRTDLNRKLPAYARVKQSRVPNAYDKTALKLEIGDIIKVTKTNINGQWEGELN-GKNGHFPFTHVEFVD 259
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Fly
Match: Crk (gene:FBgn0024811 transcript:FBtr0089112) HSP 1 Score: 83.5741 bits (205), Expect = 3.476e-18 Identity = 66/249 (26.51%), Postives = 116/249 (46.59%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEAD-GTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDG----WKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQTYH--PKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQSSN-------DKT----SLQQMVFK-------MQSRVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WYFG +SR +A + E + G +L+RD N I G YVL V+E T+ + YII+ + ++IG+ FD++ LL+ ++ + + L PA + +V+ + +L + + V K +++ + IG +PV ++Q + DK S VF+ + ++P + R PN +DK+ L +++GD + V NG + + GK+G PF V D Sbjct: 12 WYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQDQIVYRIGDQSFDNLPKLLTFYTLHYLDTTPLKRPACRRVEKVIGKFDFVGSDQDDLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQQYDDYMDEDAIDKNEPSISGSSNVFESTLKRTDLNRKLPAYARVKQSRVPNAYDKTALKLEIGDIIKVTKTNINGQWEGELN-GKNGHFPFTHVEFVD 259
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Fly
Match: Crk (gene:FBgn0024811 transcript:FBtr0304871) HSP 1 Score: 68.9366 bits (167), Expect = 1.450e-13 Identity = 43/153 (28.10%), Postives = 78/153 (50.98%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEAD-GTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDG----WKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQTYH--PKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQS 640 WYFG +SR +A + E + G +L+RD N I G YVL V+E T+ + YII+ + ++IG+ FD++ LL+ ++ + + L PA + +V+ + +L + + V K +++ + IG +PV ++QS Sbjct: 12 WYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQDQIVYRIGDQSFDNLPKLLTFYTLHYLDTTPLKRPACRRVEKVIGKFDFVGSDQDDLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQQS 164
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Fly
Match: Crk (gene:FBgn0024811 transcript:FBtr0308256) HSP 1 Score: 69.707 bits (169), Expect = 2.133e-13 Identity = 61/243 (25.10%), Postives = 111/243 (45.68%), Query Frame = 2 Query: 221 SRDEAQNSIFMEAD-GTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDG----WKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQTYH--PKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQSSN-------DKT----SLQQMVFK-------MQSRVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 +R +A + E + G +L+RD N I G YVL V+E T+ + YII+ + ++IG+ FD++ LL+ ++ + + L PA + +V+ + +L + + V K +++ + IG +PV ++Q + DK S VF+ + ++P + R PN +DK+ L +++GD + V NG + + GK+G PF V D Sbjct: 10 NRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQDQIVYRIGDQSFDNLPKLLTFYTLHYLDTTPLKRPACRRVEKVIGKFDFVGSDQDDLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQQYDDYMDEDAIDKNEPSISGSSNVFESTLKRTDLNRKLPAYARVKQSRVPNAYDKTALKLEIGDIIKVTKTNINGQWEGELN-GKNGHFPFTHVEFVD 251
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Fly
Match: Crk (gene:FBgn0024811 transcript:FBtr0089114) HSP 1 Score: 67.3958 bits (163), Expect = 1.225e-12 Identity = 61/245 (24.90%), Postives = 108/245 (44.08%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEAD-GTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDGWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQTYH--PKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQSSN-------DKT----SLQQMVFK-------MQSRVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WYFG +SR +A + E + G +L+RD N I G YVL + I+ ++IG+ FD++ LL+ ++ + + L PA + +V+ + +L + + V K +++ + IG +PV ++Q + DK S VF+ + ++P + R PN +DK+ L +++GD + V NG + + GK+G PF V D Sbjct: 12 WYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCDQ--------IV------YRIGDQSFDNLPKLLTFYTLHYLDTTPLKRPACRRVEKVIGKFDFVGSDQDDLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQQYDDYMDEDAIDKNEPSISGSSNVFESTLKRTDLNRKLPAYARVKQSRVPNAYDKTALKLEIGDIIKVTKTNINGQWEGELN-GKNGHFPFTHVEFVD 241
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Zebrafish
Match: crk (v-crk avian sarcoma virus CT10 oncogene homolog [Source:ZFIN;Acc:ZDB-GENE-040801-148]) HSP 1 Score: 71.2478 bits (173), Expect = 1.506e-13 Identity = 71/291 (24.40%), Postives = 119/291 (40.89%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYII----SPYKDG-------WKIGNTEFDSIESLLSHFSKVIIRQSTLTNP------------------AP----KPFYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQ---------------------SSNDKTSLQQMVFKMQS-------------RVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WY+G LSR EA + + + G +L+RD I G YVL V E ++ + YII S + G ++IG+ EFD++ +LL + + +TL P AP + + R L + D +L + +R + K +E+ +G +PV +++ ++D S Q + P AI+ R PN +DK+ L+++VGD + V + NG + + + GK G PF V + D Sbjct: 13 WYWGRLSRQEAVSLLQGQRHGVFLVRDSITIPGDYVLSVSENSKVSHYIINSISSNRQSGPGLAPPRFRIGDQEFDALPALLEFYKIHYLDTTTLIEPISKSKHSSFISVNAGTGGAPPRLEEEYVRALFDFPGNDDEDLPFRKGDVLRVLEKPEEQWWNAQNSEGRVGMIPVPYVEKYRPASPTSGAPGVSVSGSGAHGNSDGHSTQSPPLLGEPGQYAQPTSLPNLQNGPVYARAIQKRVPNAYDKTALALEVGDMVKVTKINVNGQWEGECK-GKHGHFPFTHVRLLD 302
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Zebrafish
Match: crk (v-crk avian sarcoma virus CT10 oncogene homolog [Source:ZFIN;Acc:ZDB-GENE-040801-148]) HSP 1 Score: 71.2478 bits (173), Expect = 1.506e-13 Identity = 71/291 (24.40%), Postives = 119/291 (40.89%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYII----SPYKDG-------WKIGNTEFDSIESLLSHFSKVIIRQSTLTNP------------------AP----KPFYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQ---------------------SSNDKTSLQQMVFKMQS-------------RVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WY+G LSR EA + + + G +L+RD I G YVL V E ++ + YII S + G ++IG+ EFD++ +LL + + +TL P AP + + R L + D +L + +R + K +E+ +G +PV +++ ++D S Q + P AI+ R PN +DK+ L+++VGD + V + NG + + + GK G PF V + D Sbjct: 13 WYWGRLSRQEAVSLLQGQRHGVFLVRDSITIPGDYVLSVSENSKVSHYIINSISSNRQSGPGLAPPRFRIGDQEFDALPALLEFYKIHYLDTTTLIEPISKSKHSSFISVNAGTGGAPPRLEEEYVRALFDFPGNDDEDLPFRKGDVLRVLEKPEEQWWNAQNSEGRVGMIPVPYVEKYRPASPTSGAPGVSVSGSGAHGNSDGHSTQSPPLLGEPGQYAQPTSLPNLQNGPVYARAIQKRVPNAYDKTALALEVGDMVKVTKINVNGQWEGECK-GKHGHFPFTHVRLLD 302
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Zebrafish
Match: crk (v-crk avian sarcoma virus CT10 oncogene homolog [Source:ZFIN;Acc:ZDB-GENE-040801-148]) HSP 1 Score: 71.2478 bits (173), Expect = 1.506e-13 Identity = 71/291 (24.40%), Postives = 119/291 (40.89%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYII----SPYKDG-------WKIGNTEFDSIESLLSHFSKVIIRQSTLTNP------------------AP----KPFYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQ---------------------SSNDKTSLQQMVFKMQS-------------RVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WY+G LSR EA + + + G +L+RD I G YVL V E ++ + YII S + G ++IG+ EFD++ +LL + + +TL P AP + + R L + D +L + +R + K +E+ +G +PV +++ ++D S Q + P AI+ R PN +DK+ L+++VGD + V + NG + + + GK G PF V + D Sbjct: 13 WYWGRLSRQEAVSLLQGQRHGVFLVRDSITIPGDYVLSVSENSKVSHYIINSISSNRQSGPGLAPPRFRIGDQEFDALPALLEFYKIHYLDTTTLIEPISKSKHSSFISVNAGTGGAPPRLEEEYVRALFDFPGNDDEDLPFRKGDVLRVLEKPEEQWWNAQNSEGRVGMIPVPYVEKYRPASPTSGAPGVSVSGSGAHGNSDGHSTQSPPLLGEPGQYAQPTSLPNLQNGPVYARAIQKRVPNAYDKTALALEVGDMVKVTKINVNGQWEGECK-GKHGHFPFTHVRLLD 302
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Zebrafish
Match: crkl (v-crk avian sarcoma virus CT10 oncogene homolog-like [Source:ZFIN;Acc:ZDB-GENE-040426-2951]) HSP 1 Score: 71.2478 bits (173), Expect = 1.571e-13 Identity = 38/92 (41.30%), Postives = 56/92 (60.87%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIIS--PYKDGWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPK 472 WYFG +SR EAQN + + G +L+RD + G YVL V E ++ + YII+ P K +KIG+ EFD++ LL + + +TL PAP+ Sbjct: 14 WYFGPVSRQEAQNRLQGQRHGMFLVRDSSTCPGDYVLSVSENSKVSHYIINSLPSKR-FKIGDQEFDNLPGLLEFYKIHYLDTTTLIEPAPR 104
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Zebrafish
Match: pik3r1 (phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [Source:ZFIN;Acc:ZDB-GENE-030131-1280]) HSP 1 Score: 50.8322 bits (120), Expect = 1.408e-6 Identity = 31/94 (32.98%), Postives = 51/94 (54.26%), Query Frame = 2 Query: 200 DWYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDGWKIGNTE---FDSIESLLSHFSKVIIRQSTLTNPAPK 472 +WY+G++SR+E + ADGT+L+RD + + G L K NK I ++DG K G ++ F+S+ L++H+ R +L PK Sbjct: 55 EWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDG-KYGFSDPLTFNSVVELINHY-----RTESLAQYNPK 142
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Xenopus
Match: kctd1 (potassium channel tetramerization domain containing 1 [Source:Xenbase;Acc:XB-GENE-6076050]) HSP 1 Score: 77.7962 bits (190), Expect = 1.015e-15 Identity = 74/284 (26.06%), Postives = 125/284 (44.01%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIIS--PYKDGWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPK---------------------PFYRVLQTYHPKSDIE-LAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILK-------------QSSND---------------------KTSLQQMVFKMQS--RVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WYFG +SR EAQ+ + + G +L+RD + G +VL V E ++ + YII+ P + +KIG+ EFD++ +LL + + +TL PAP+ + R L + P +D E L + + + V K +E+ IG +PV ++ ++SN ++ ++ +QS P AI+ R P +DK+ L+++VGD + V + NG + + G+ GL PF V I D Sbjct: 14 WYFGPVSRQEAQSRLQGQRHGVFLVRDSSTCPGDHVLSVSENSRVSHYIINSLPGRR-YKIGDQEFDNLPALLDFYKIHYLDTTTLIEPAPRYPSPPVGTGTAPSVPVPEENLEYVRTLYDF-PGNDAEDLPFKKGEILVIVEKPEEQWWSARNKDGRIGMIPVPYVEKLSRLSLHGKMGNRNSNSYGIPEPAHAYAQPQTPSPLPASSTPPAVINPLQSTQNGPVYAKAIQKRVPCAYDKTALALEVGDLVKVTRMNINGQWEGEVN-GRKGLFPFTHVKIID 294
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Xenopus
Match: mvb12b (multivesicular body subunit 12B [Source:Xenbase;Acc:XB-GENE-945521]) HSP 1 Score: 73.1738 bits (178), Expect = 3.845e-14 Identity = 66/276 (23.91%), Postives = 112/276 (40.58%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDG-----------WKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKP-------------FYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQSSNDKTSLQQMVFKMQSRV----------------------------PFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WY+G L+R EA N + + G +L+RD I G YVL V E ++ + YII+ + ++IG+ EFDS+ SLL + + +TL P K + R L ++ D +L + +R K +E+ G +PV +++ ++ ++ Q P I+ R PN +DK+ L+++VGD + V + +G + + GK G PF V + D Sbjct: 13 WYWGKLNRQEAVNLLQGQRHGVFLVRDSTTIPGDYVLSVSENSKVSHYIINSVSNNRQSGTGMIQSRFRIGDQEFDSLPSLLEFYKIHYLDTTTLIEPVSKSKQSGVIQRQEEVEYVRALFDFNGNDDEDLPFKKGDILRIRDKPEEQWWNAEDNDGRRGMIPVPYVEKYRPPSSAGSALIGGNQENSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIFARVIQKRVPNAYDKTALALEVGDLVKVTKINVSGQWEGECN-GKYGHFPFTHVRLLD 287
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Xenopus
Match: mvb12b (multivesicular body subunit 12B [Source:Xenbase;Acc:XB-GENE-945521]) HSP 1 Score: 72.7886 bits (177), Expect = 6.070e-14 Identity = 69/277 (24.91%), Postives = 114/277 (41.16%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDG------------WKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKP-------------FYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQ------------SSNDKTSLQQMVFKMQS--------RVPFKTL--------AIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WY+G L+R EA N + + G +L+RD I G YVL V E ++ + YII+ + ++IG+ EFDS+ SLL + + +TL P K + R L ++ D +L + +R K +E+ G +PV +++ N + S Q + + P L I+ R PN +DK+ L+++VGD + V + +G + + GK G PF V + D Sbjct: 13 WYWGKLNRQEAVNLLQGQRHGVFLVRDSTTIPGDYVLSVSENSKVSHYIINSVSNNRQSGTEPAPSSRFRIGDQEFDSLPSLLEFYKIHYLDTTTLIEPVSKSKQSGVIQRQEEVEYVRALFDFNGNDDEDLPFKKGDILRIRDKPEEQWWNAEDNDGRRGMIPVPYVEKYRPPSSAGSALIGGNQENSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIFARVIQKRVPNAYDKTALALEVGDLVKVTKINVSGQWEGECN-GKYGHFPFTHVRLLD 288
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Xenopus
Match: PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1 [Source:NCBI gene;Acc:100486835]) HSP 1 Score: 53.5286 bits (127), Expect = 2.761e-7 Identity = 35/115 (30.43%), Postives = 59/115 (51.30%), Query Frame = 2 Query: 152 PKEYSILRNLMQNHV-----KDWYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDGWKIGNTE---FDSIESLLSHFSKVIIRQSTLTNPAPK 472 P + + + N NH+ +WY+G++SR+E + DGT+L+RD + I+ G L K NK I ++DG K G ++ F+S+ L++H+ R +L PK Sbjct: 51 PPKSTAVTNNGTNHIMSLQDAEWYWGDISREEVNEKLRDTTDGTFLVRDASTIMHGDYTLTLRKGGNNKLIKIFHRDG-KYGFSDPLTFNSVVELITHY-----RNESLAQYNPK 159
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Xenopus
Match: PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1 [Source:NCBI gene;Acc:100486835]) HSP 1 Score: 53.1434 bits (126), Expect = 3.139e-7 Identity = 35/115 (30.43%), Postives = 59/115 (51.30%), Query Frame = 2 Query: 152 PKEYSILRNLMQNHV-----KDWYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDGWKIGNTE---FDSIESLLSHFSKVIIRQSTLTNPAPK 472 P + + + N NH+ +WY+G++SR+E + DGT+L+RD + I+ G L K NK I ++DG K G ++ F+S+ L++H+ R +L PK Sbjct: 41 PPKSTAVTNNGTNHIMSLQDAEWYWGDISREEVNEKLRDTTDGTFLVRDASTIMHGDYTLTLRKGGNNKLIKIFHRDG-KYGFSDPLTFNSVVELITHY-----RNESLAQYNPK 149
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Mouse
Match: Crkl (v-crk avian sarcoma virus CT10 oncogene homolog-like [Source:MGI Symbol;Acc:MGI:104686]) HSP 1 Score: 76.6406 bits (187), Expect = 2.550e-15 Identity = 70/284 (24.65%), Postives = 119/284 (41.90%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKD-GWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPK---------------------PFYRVLQTYHPKSDIE-LAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPV----NILKQSSNDK-----------TSLQQMVFKMQSRVPFKTL----------------------AIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WY G ++R EAQ + + G +L+RD + G YVL V E ++ + YII+ + +KIG+ EFD + +LL + + +TL PAP+ + R L + P +D E L + + + + K +E+ +G +PV +++ S + K + Q+ P T+ AI+ R P +DK+ L+++VGD + V + NG + + G+ GL PF V I D Sbjct: 14 WYMGPVTRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPVGSVSAPNLPTAEENLEYVRTLYDF-PGNDAEDLPFKKGELLVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPTVASTPGAAINPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVN-GRKGLFPFTHVKIFD 295
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Mouse
Match: Crkl (v-crk avian sarcoma virus CT10 oncogene homolog-like [Source:MGI Symbol;Acc:MGI:104686]) HSP 1 Score: 65.0846 bits (157), Expect = 7.863e-13 Identity = 33/91 (36.26%), Postives = 53/91 (58.24%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKD-GWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPK 472 WY G ++R EAQ + + G +L+RD + G YVL V E ++ + YII+ + +KIG+ EFD + +LL + + +TL PAP+ Sbjct: 14 WYMGPVTRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPR 104
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Mouse
Match: Crkl (v-crk avian sarcoma virus CT10 oncogene homolog-like [Source:MGI Symbol;Acc:MGI:104686]) HSP 1 Score: 65.855 bits (159), Expect = 1.314e-12 Identity = 33/91 (36.26%), Postives = 53/91 (58.24%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKD-GWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPK 472 WY G ++R EAQ + + G +L+RD + G YVL V E ++ + YII+ + +KIG+ EFD + +LL + + +TL PAP+ Sbjct: 14 WYMGPVTRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPR 104
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Mouse
Match: Crk (v-crk avian sarcoma virus CT10 oncogene homolog [Source:MGI Symbol;Acc:MGI:88508]) HSP 1 Score: 65.0846 bits (157), Expect = 2.028e-11 Identity = 64/286 (22.38%), Postives = 111/286 (38.81%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYII--------------------SPYKDGWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKP--------------FYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQSSNDKTSLQQMVFKMQS----------------------------RVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WY+G LSR EA + + G +L+RD + G YVL V E ++ + YII SP + +IG+ EFDS+ +LL + + +TL P + + R L ++ + +L + +R K +E+ G +PV +++ S+ ++ Q P I+ R PN +DK+ L+++VG+ + V + +G + + GK G PF V + D Sbjct: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSR--LRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVARSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECN-GKRGHFPFTHVRLLD 295
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Mouse
Match: Crk (v-crk avian sarcoma virus CT10 oncogene homolog [Source:MGI Symbol;Acc:MGI:88508]) HSP 1 Score: 53.9138 bits (128), Expect = 3.984e-8 Identity = 40/151 (26.49%), Postives = 64/151 (42.38%), Query Frame = 2 Query: 176 NLMQNHVKDWYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYII--------------------SPYKDGWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQTYHPKSDIELAVNECQFVRFVLKYD 568 N WY+G LSR EA + + G +L+RD + G YVL V E ++ + YII SP + +IG+ EFDS+ +LL + + +TL P + S + L E ++VR + ++ Sbjct: 4 NFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSR--LRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVARS--------RQGSGVILRQEEAEYVRALFDFN 144
BLAST of Potassium channel tetramerization domain containing 1 vs. UniProt/SwissProt
Match: sp|Q9XYM0|CRK_DROME (Adapter molecule Crk OS=Drosophila melanogaster OX=7227 GN=Crk PE=1 SV=1) HSP 1 Score: 83.5741 bits (205), Expect = 3.485e-17 Identity = 66/249 (26.51%), Postives = 116/249 (46.59%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEAD-GTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDG----WKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQTYH--PKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQSSN-------DKT----SLQQMVFK-------MQSRVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WYFG +SR +A + E + G +L+RD N I G YVL V+E T+ + YII+ + ++IG+ FD++ LL+ ++ + + L PA + +V+ + +L + + V K +++ + IG +PV ++Q + DK S VF+ + ++P + R PN +DK+ L +++GD + V NG + + GK+G PF V D Sbjct: 12 WYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQDQIVYRIGDQSFDNLPKLLTFYTLHYLDTTPLKRPACRRVEKVIGKFDFVGSDQDDLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQQYDDYMDEDAIDKNEPSISGSSNVFESTLKRTDLNRKLPAYARVKQSRVPNAYDKTALKLEIGDIIKVTKTNINGQWEGELN-GKNGHFPFTHVEFVD 259
BLAST of Potassium channel tetramerization domain containing 1 vs. UniProt/SwissProt
Match: sp|Q5U2U2|CRKL_RAT (Crk-like protein OS=Rattus norvegicus OX=10116 GN=Crkl PE=1 SV=1) HSP 1 Score: 77.7962 bits (190), Expect = 6.588e-15 Identity = 71/284 (25.00%), Postives = 119/284 (41.90%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKD-GWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPK---------------------PFYRVLQTYHPKSDIE-LAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPV----NILKQSSNDK-----------TSLQQMVFKMQSRVPFKTL----------------------AIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WY G +SR EAQ + + G +L+RD + G YVL V E ++ + YII+ + +KIG+ EFD + +LL + + +TL PAP+ + R L + P +D E L + + + + K +E+ +G +PV +++ S + K + Q+ P T+ AI+ R P +DK+ L+++VGD + V + NG + + G+ GL PF V I D Sbjct: 14 WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPNPPMGSVSAPNLSTAEENLEYVRTLYDF-PGNDAEDLPFKKGELLVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPTVASTPGAAINPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVN-GRKGLFPFTHVKIFD 295
BLAST of Potassium channel tetramerization domain containing 1 vs. UniProt/SwissProt
Match: sp|P47941|CRKL_MOUSE (Crk-like protein OS=Mus musculus OX=10090 GN=Crkl PE=1 SV=2) HSP 1 Score: 76.6406 bits (187), Expect = 1.783e-14 Identity = 70/284 (24.65%), Postives = 119/284 (41.90%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKD-GWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPK---------------------PFYRVLQTYHPKSDIE-LAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPV----NILKQSSNDK-----------TSLQQMVFKMQSRVPFKTL----------------------AIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WY G ++R EAQ + + G +L+RD + G YVL V E ++ + YII+ + +KIG+ EFD + +LL + + +TL PAP+ + R L + P +D E L + + + + K +E+ +G +PV +++ S + K + Q+ P T+ AI+ R P +DK+ L+++VGD + V + NG + + G+ GL PF V I D Sbjct: 14 WYMGPVTRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPVGSVSAPNLPTAEENLEYVRTLYDF-PGNDAEDLPFKKGELLVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPTVASTPGAAINPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVN-GRKGLFPFTHVKIFD 295
BLAST of Potassium channel tetramerization domain containing 1 vs. UniProt/SwissProt
Match: sp|P46109|CRKL_HUMAN (Crk-like protein OS=Homo sapiens OX=9606 GN=CRKL PE=1 SV=1) HSP 1 Score: 75.485 bits (184), Expect = 3.650e-14 Identity = 70/284 (24.65%), Postives = 118/284 (41.55%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKD-GWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPK---------------------PFYRVLQTYHPKSDIE-LAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPV----NILKQSSNDK-----------TSLQQMVFKMQSRVPFKTL----------------------AIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WY G +SR EAQ + + G +L+RD + G YVL V E ++ + YII+ + +KIG+ EFD + +LL + + +TL PAP+ + R L + P +D E L + + + + K +E+ +G +PV +++ S + K + Q+ P + AI+ R P +DK+ L+++VGD + V + NG + + G+ GL PF V I D Sbjct: 14 WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDF-PGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVN-GRKGLFPFTHVKIFD 295
BLAST of Potassium channel tetramerization domain containing 1 vs. UniProt/SwissProt
Match: sp|Q9NHC3|CED2_CAEEL (Cell death abnormality protein 2 OS=Caenorhabditis elegans OX=6239 GN=ced-2 PE=1 SV=1) HSP 1 Score: 73.1738 bits (178), Expect = 1.974e-13 Identity = 67/260 (25.77%), Postives = 116/260 (44.62%), Query Frame = 2 Query: 197 KDWYFGNLSRDEAQNSIFMEAD---GTYLIRDCNQILGGYVLLVKEKTQTNK---YIIS---PYKDGW-----KIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQ---TYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILK---QSSNDKTSLQQMV----------------------FKMQSRVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVP 850 + +YF +SR+EA + + E GT+L+RD ++ G Y L V+E + N Y+I P +DG KI N F I +LL+HF ++ +++L KP V+ + + + +L + + + + K ++ G +P N ++ + ND+TS ++Q R+P K DR PN +D +QL VK G +++V + NGM + + G+ G VP Sbjct: 12 RSFYFPGMSREEA-HKLLGEPQVSIGTFLMRDSSRP-GEYSLTVREADEGNAVCHYLIERGEPKEDGTAAAGVKIANQSFPDIPALLNHFKMRVLTEASLLAAYKKPIIEVVVGTFKFTGERETDLPFEQGERLEILSKTNQDWWEARNALGTTGLVPANYVQIQMEFHNDRTSKGASQSSIGSSGGGAERFSSASTSSDNIELQPRLPAKAKVTFDRVPNAYDPTQLRVKKGQTVLVTQKMSNGMYKAELD-GQIGSVP 268
BLAST of Potassium channel tetramerization domain containing 1 vs. TrEMBL
Match: A0A267E300 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig006820g3 PE=4 SV=1) HSP 1 Score: 117.087 bits (292), Expect = 1.454e-26 Identity = 88/245 (35.92%), Postives = 127/245 (51.84%), Query Frame = 2 Query: 194 VKDWYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKY--IISPYK--DGWK--IGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQTYHPKSD---IELAVNEC-QFVRFVLKYDEKILCE--HQL---TKAIGWLPVNILKQSSNDKTSLQQMVFKMQSRVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGM-------LQTKNQFGKDGLVPFNIV 862 +DWYFG+++R++A + G YL+R G +VL V++ QTN Y ++ P K DG+K IG TEF I+ +L+++ K + STLT PAP+P YRV Y P SD I L NEC F+ K D E H L T +G +P + L+Q SN + +Q +PF ++ R PN+FD SQL ++ GD + V + N L+TK +G+ PFN V Sbjct: 13 TEDWYFGSINREQANEILLSGQVGMYLVRASKTERGSFVLSVRDTQQTNHYKIVVLPRKNSDGFKFRIGPTEFLFIQDILNYYKKNKLVDSTLTVPAPRPVYRVKIDYRPDSDASAIGLRRNECVLFLDVATKPDGAEDAEWWHVLKKNTGEVGCVPKSCLRQ-SNPGGEDGKFAVLLQLNLPFDVEVVRPRNPNIFDPSQLRMEPGDHIRVKKMDPNSPELWYGVNLRTK----AEGVFPFNYV 252
BLAST of Potassium channel tetramerization domain containing 1 vs. TrEMBL
Match: A0A267FM75 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig028588g1 PE=4 SV=1) HSP 1 Score: 116.701 bits (291), Expect = 1.611e-26 Identity = 88/245 (35.92%), Postives = 127/245 (51.84%), Query Frame = 2 Query: 194 VKDWYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKY--IISPYK--DGWK--IGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQTYHPKSD---IELAVNEC-QFVRFVLKYDEKILCE--HQL---TKAIGWLPVNILKQSSNDKTSLQQMVFKMQSRVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGM-------LQTKNQFGKDGLVPFNIV 862 +DWYFG+++R++A + G YL+R G +VL V++ QTN Y ++ P K DG+K IG TEF I+ +L+++ K + STLT PAP+P YRV Y P SD I L NEC F+ K D E H L T +G +P + L+Q SN + +Q +PF ++ R PN+FD SQL ++ GD + V + N L+TK +G+ PFN V Sbjct: 13 TEDWYFGSINREQANEILLSGQVGMYLVRASKTERGSFVLSVRDTQQTNHYKIVVLPRKNSDGFKFRIGPTEFLFIQDILNYYKKNKLVDSTLTVPAPRPVYRVKIDYRPDSDASAIGLRRNECVLFLDVATKPDGAEDAEWWHVLKKNTGEVGCVPKSCLRQ-SNPGGEDGKFAVLLQLNLPFDVEVVRPRNPNIFDTSQLRMEPGDHIRVKKMDPNSPELWYGVNLRTK----AEGVFPFNYV 252
BLAST of Potassium channel tetramerization domain containing 1 vs. TrEMBL
Match: A0A504Z2Q1 (Adapter molecule Crk OS=Fasciola gigantica OX=46835 GN=FGIG_03137 PE=4 SV=1) HSP 1 Score: 112.849 bits (281), Expect = 1.403e-25 Identity = 66/236 (27.97%), Postives = 117/236 (49.58%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIIS--PYKDGWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILK----------QSSNDKTSLQQMVFKMQSRVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQT-KNQFGKDGLVPFNIVNIN 871 WYFG +SR++ + + GT+L+RD + GY L VKE +Y+IS P+ ++ G++ +DS + L+ +++ L PAPK Y L Y + + +L+ N + F+ + + + C+ + T +GW+P+N L + D+ SL ++P I+DR P++F L V+VGD + + +L +G + + Q GLVP N + I+ Sbjct: 11 WYFGEISREKTNEILVDQPVGTFLVRD-STTKSGYALAVKEANGVKRYLISYIPHSKKFRFGDSLYDSFDDLIRQYTETKTSACRLKQPAPKAVYIGLHNYISQEESDLSFNRGDILHFIRQKKDWVFCKSE-TDRVGWVPLNYLVPFTPELASRLRGHTDQASLSHCRKADFVKLPAPGKVIRDRNPSIFLNGHLKVQVGDEVKINKILSDGFCEVLREQDHLSGLVPINCLEIH 244
BLAST of Potassium channel tetramerization domain containing 1 vs. TrEMBL
Match: A0A4E0RD41 (Adapter molecule Crk OS=Fasciola hepatica OX=6192 GN=D915_003771 PE=4 SV=1) HSP 1 Score: 112.849 bits (281), Expect = 1.403e-25 Identity = 66/236 (27.97%), Postives = 117/236 (49.58%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIIS--PYKDGWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILK----------QSSNDKTSLQQMVFKMQSRVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQT-KNQFGKDGLVPFNIVNIN 871 WYFG +SR++ + + GT+L+RD + GY L VKE +Y+IS P+ ++ G++ +DS + L+ +++ L PAPK Y L Y + + +L+ N + F+ + + + C+ + T +GW+P+N L + D+ SL ++P I+DR P++F L V+VGD + + +L +G + + Q GLVP N + I+ Sbjct: 11 WYFGEISREKTNEILVDQPVGTFLVRD-STTKSGYALAVKEANGVKRYLISYIPHSKKFRFGDSLYDSFDDLIRQYTETKTSACRLKQPAPKAVYIGLHNYISQEESDLSFNRGDILHFIRQKKDWVFCKSE-TDRVGWVPLNYLVPFTPELASRLRGHTDQASLSHCRKADFVKLPAPGKVIRDRNPSIFLNGHLKVQVGDEVKINKILSDGFCEVLREQDHLSGLVPINCLEIH 244
BLAST of Potassium channel tetramerization domain containing 1 vs. TrEMBL
Match: A0A1S8WWL6 (SH2 domain protein (Fragment) OS=Opisthorchis viverrini OX=6198 GN=X801_05231 PE=4 SV=1) HSP 1 Score: 109.768 bits (273), Expect = 1.834e-24 Identity = 70/242 (28.93%), Postives = 123/242 (50.83%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIIS--PYKDGWKIGNTEFDSIESLLSHF--SKVIIRQSTLTNPAPKPFYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQ-------------SSNDKTSLQQMVFKMQS-RVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WYFG LSR++ + + GT+L+RD + G+VL VKE +++I P ++ G + +DS++ L+ H+ SK +R LT PAPK Y L + K D E++ + + + F+ + + +LC+ + + IGW+PVN +++ ND+ + K + +P I+ R P+ F + L ++VG+ L V VL++G + + GLVP N + + D Sbjct: 1 WYFGELSREKTNELLLDQPVGTFLVRD-STTHSGFVLTVKESDGVKRFLIPFMPMSQKFRFGESLYDSLDDLIRHYMNSKSAMR---LTQPAPKDVYLGLYNFQAKDDTEVSFSRAERLYFIRQKGQWMLCKAESSGQIGWVPVNYVQEVGPFSPELHARLSGQNDQACVVSDCRKGKFLSLPKTGKVIRARNPSAFLEGHLKIQVGELLRVYKVLQDGFCEVWREDQVSGLVPINYLELLD 238
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Cavefish
Match: crk (CRK proto-oncogene, adaptor protein [Source:NCBI gene;Acc:103035530]) HSP 1 Score: 71.633 bits (174), Expect = 1.081e-13 Identity = 71/287 (24.74%), Postives = 118/287 (41.11%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYII----SPYKDG-------WKIGNTEFDSIESLLSHFSKVIIRQSTLTNP----------------APK----PFYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQ--------------------SSNDKTS------------LQQMVFKMQSRVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WY+G LSR EA + + + G +L+RD G YVL V E ++ + YII S + G ++IG+ EFD++ +LL + + +TL P AP+ + R L + D +L + +R + K +E+ +G +PV +++ +S+ S Q P AI+ R PN +DK+ L+++VGD +MV + NG + + + GK G PF V + D Sbjct: 13 WYWGRLSRQEAVSLLQGQRHGVFLVRDSITSPGDYVLSVSENSKVSHYIINSISSNRQSGPGLTTSRFRIGDQEFDALPALLEFYKIHYLDTTTLIEPINKAKHSSVINISAGGAPQRLEEEYVRALFDFPGNDDEDLPFRKGDVLRVLEKPEEQWWNAQNSEGRVGMIPVPYVEKFRPASPGSGTLGSGGTGTVGNSDGHNSQSPPLLGEPGQYAQPTSLPNLQNGPVLARAIQKRVPNAYDKTALALEVGDLVMVTKINVNGQWEGECK-GKRGHFPFTHVRLLD 298
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Cavefish
Match: crkl (v-crk avian sarcoma virus CT10 oncogene homolog-like [Source:ZFIN;Acc:ZDB-GENE-040426-2951]) HSP 1 Score: 67.781 bits (164), Expect = 2.159e-12 Identity = 36/92 (39.13%), Postives = 56/92 (60.87%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIIS--PYKDGWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPK 472 WYFG+LSR E Q+ + + G +L+RD + G YVL V E ++ + YII+ P K +KIG+ EF+ + +LL + + +TL PAP+ Sbjct: 21 WYFGSLSRQETQSRLQGQRHGMFLVRDSSTCPGDYVLSVSENSKVSHYIINSLPSKR-FKIGDQEFEHLPALLEFYKIHYLDTTTLIEPAPR 111
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Cavefish
Match: CRK (adapter molecule crk-like [Source:NCBI gene;Acc:103038949]) HSP 1 Score: 65.855 bits (159), Expect = 1.019e-11 Identity = 67/294 (22.79%), Postives = 114/294 (38.78%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDG-----------WKIGNTEFDSIESLLSHFSKVIIRQSTLTNP-----------------APK-----PFYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEH--------------------QLTKAIGWLPVNILKQSSNDKTSLQQMVFKMQSRV-----------------PFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WY+G ++R EA + + G +L+RD I G YVL V E ++ + YII+ + ++IG+ EFD++ LL + + +TL P AP+ + R L + D +L + +R + K +E+ T +G PV + SL + +++ P AI+ R PN +DK+ L+++VGD + V + NG + + + GK G PF V + D Sbjct: 13 WYWGKINRKEAVTLLQGQRHGVFLVRDSTTIRGDYVLSVSENSKVSHYIINSISNNRQSGSGLMSSRFRIGDQEFDTLPGLLEFYKIHYLDTTTLIEPINRSKHASFISTAAPAGAPQRSEDAEYVRALFDFPGNDDEDLPFRKGDVLRVLEKPEEQWWNAQNSEGRSGMIPVPYVEKYRPSSPTSQLGGAPVGQTGLGTPSVGSLDGNGGPVPTKLDYAQPVVNTPLPNLQNGPVYARAIQKRVPNAYDKTALALEVGDMVTVTKINVNGQWEGECK-GKKGHFPFTHVRLLD 305
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Cavefish
Match: CRK (adapter molecule crk-like [Source:NCBI gene;Acc:103038949]) HSP 1 Score: 65.0846 bits (157), Expect = 1.611e-11 Identity = 67/296 (22.64%), Postives = 114/296 (38.51%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDG-------------WKIGNTEFDSIESLLSHFSKVIIRQSTLTNP-----------------APK-----PFYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEH--------------------QLTKAIGWLPVNILKQSSNDKTSLQQMVFKMQSRV-----------------PFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WY+G ++R EA + + G +L+RD I G YVL V E ++ + YII+ + ++IG+ EFD++ LL + + +TL P AP+ + R L + D +L + +R + K +E+ T +G PV + SL + +++ P AI+ R PN +DK+ L+++VGD + V + NG + + + GK G PF V + D Sbjct: 13 WYWGKINRKEAVTLLQGQRHGVFLVRDSTTIRGDYVLSVSENSKVSHYIINSISNNRPCTFCPSLMSSRFRIGDQEFDTLPGLLEFYKIHYLDTTTLIEPINRSKHASFISTAAPAGAPQRSEDAEYVRALFDFPGNDDEDLPFRKGDVLRVLEKPEEQWWNAQNSEGRSGMIPVPYVEKYRPSSPTSQLGGAPVGQTGLGTPSVGSLDGNGGPVPTKLDYAQPVVNTPLPNLQNGPVYARAIQKRVPNAYDKTALALEVGDMVTVTKINVNGQWEGECK-GKKGHFPFTHVRLLD 307
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Cavefish
Match: pik3r1 (phosphoinositide-3-kinase regulatory subunit 1 [Source:NCBI gene;Acc:103046618]) HSP 1 Score: 54.299 bits (129), Expect = 1.069e-7 Identity = 36/121 (29.75%), Postives = 60/121 (49.59%), Query Frame = 2 Query: 170 LRNLMQNHVKDWYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDGWKIGNTE---FDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQTYHPKSDIEL 523 + N M H +WY+G++SR+E + ADGT+L+RD + + G L K NK I ++DG K G ++ F+S+ L++H+ + L Y+PK D++L Sbjct: 324 MNNNMALHDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDG-KYGFSDPLTFNSVVELINHYR-----------------HESLAQYNPKLDVKL 426
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Sea Lamprey
Match: crkl (v-crk avian sarcoma virus CT10 oncogene homolog-like [Source:ZFIN;Acc:ZDB-GENE-040426-2951]) HSP 1 Score: 79.337 bits (194), Expect = 4.077e-17 Identity = 69/287 (24.04%), Postives = 117/287 (40.77%), Query Frame = 2 Query: 191 HVKD-WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDGWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPA---PKP--------------------------FYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQSSNDKT-----------------------------SLQQMVFKMQSRVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 H +D WYFG LSR E Q + + GT+++RD G YVL V E ++ + YI++ D +KIG+ EF + +LL + + +TL PA P P F R L + + +L + + V K +E+ G +PV ++++S + ++ Q + +Q+ P I+ R PN +DK+ L++ +G+ + V + NG + + G+ G PF V I D Sbjct: 9 HDRDSWYFGPLSRVETQRRLQGQRHGTFVVRDSTTCPGDYVLSVSENSKVSHYIVNNLADRFKIGDQEFRDLPALLEFYRIHYLDTTTLIEPAGQSPSPPASKKHQQGGGGGGGSGGGGVDESVEFVRALFDFPGNDEEDLPFKRGEILTIVAKPEEQWWSARNKEGRTGMVPVPYVEKASRPLSYAASSMAPGNRNSYGSGQGGDQGPYAHPLAIGQQLPNLQNG-PVLATVIQKRVPNAYDKTALALDIGEVVTVTKMHVNGQWEGEVN-GRRGHFPFTHVRIID 293
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Sea Lamprey
Match: pik3r1 (phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [Source:ZFIN;Acc:ZDB-GENE-030131-1280]) HSP 1 Score: 49.6766 bits (117), Expect = 5.100e-7 Identity = 31/94 (32.98%), Postives = 49/94 (52.13%), Query Frame = 2 Query: 200 DWYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDGWKIGNTE---FDSIESLLSHFSKVIIRQSTLTNPAPK 472 +WY+G++SR+E + DGTYL+RD + + G L K NK I ++D K G +E F+S+ L++H+ R +L PK Sbjct: 68 EWYWGDISREEVNEKLRNTPDGTYLVRDASTKMQGDYTLTLRKGGNNKLIKIFHRDS-KYGFSEPLTFNSVVELITHY-----RHESLAQYNPK 155
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Nematostella
Match: EDO38500 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCW1]) HSP 1 Score: 51.6026 bits (122), Expect = 1.459e-7 Identity = 28/89 (31.46%), Postives = 44/89 (49.44%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDGWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAP 469 WY G L R E + + + G +L+RD I G YVL V E + + YII+ + IG+ F + S++ + K + +TL P Sbjct: 9 WYHGVLKRVETEGILNGKPPGVWLVRDSTTIPGDYVLSVSESGKVSHYIINNKGTMYTIGDQTFPDLPSIIEFYKKHFLDTTTLKEHVP 97
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Medaka
Match: crkl (CRK like proto-oncogene, adaptor protein [Source:NCBI gene;Acc:101164077]) HSP 1 Score: 66.6254 bits (161), Expect = 4.702e-12 Identity = 36/90 (40.00%), Postives = 55/90 (61.11%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIIS--PYKDGWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPA 466 WYFG +SR EAQN + + G +L+RD + G YVL V E ++ + YII+ P K +KIG+ EF+++ +LL + + +TL PA Sbjct: 14 WYFGPVSRQEAQNRLQGQRHGMFLVRDSSTCPGDYVLSVSENSKVSHYIINSLPSKR-FKIGDQEFENLPALLEFYKIHYLDTTTLIEPA 102
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Medaka
Match: crk (CRK proto-oncogene, adaptor protein [Source:NCBI gene;Acc:101157634]) HSP 1 Score: 66.2402 bits (160), Expect = 6.334e-12 Identity = 69/295 (23.39%), Postives = 117/295 (39.66%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDG-----------WKIGNTEFDSIESLLSHFSKVIIRQSTLTNP-----------------APK----PFYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQ-------------------------SSNDKTSLQQMV------FKMQSRVPFKTL--------AIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNIND 874 WY+G LSR EA + + + G +L+RD G YVL V E ++ + YII+ + ++IG+ EFD++ +LL + + +TL P AP F R L + + +L + +R + K +E+ G +PV +++ ++D + Q V + P L AI+ R PN +DK+ L+++VGD + V + NG + + + GK G PF V + D Sbjct: 13 WYWGRLSRQEAVSLLQGQRHGVFLVRDSITSPGDYVLSVSENSKVSHYIINSISNNRQSGPGLSHPRFRIGDQEFDALPALLEFYKIHYLDTTTLIEPINKSKHPSGMSVAHGGGAPPRLEDEFVRALFDFPGNDEEDLPFRKGDILRVLEKPEEQWWNAQNSEGRTGMIPVPYVEKYRPSSPSSAAGPGMAGGAPGVLPLHGNSDGSGAQPGVPLLGDPSQYAQPTPLPNLQNGPVYARAIQKRVPNAYDKTALALEVGDMVKVTKINVNGQWEGECK-GKRGHFPFTHVKLLD 306
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Medaka
Match: ENSORLT00000045629.1 (adapter molecule crk [Source:NCBI gene;Acc:110016423]) HSP 1 Score: 64.6994 bits (156), Expect = 2.086e-11 Identity = 67/292 (22.95%), Postives = 113/292 (38.70%), Query Frame = 2 Query: 203 WYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDG-----------WKIGNTEFDSIESLLSHFSKVIIRQSTL-------------TNPAPKP------FYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPV------------------------------------NILKQSSNDKTSLQQMVFKMQ----SRVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNI 868 WY+G LSR +A + + + G +L+RD G YVL V E ++ + YII+ + ++IG+ EF+++ +LL + + +TL + PA P F R L + + +L + +R + K +E+ IG +PV + L + Q V Q P AI+ R PN +DK+ L+++VGD + V + NG + + + GK G PF V + Sbjct: 13 WYWGRLSRQDAVSFLQGQRHGVFLVRDSITSPGDYVLSVSENSKVSHYIINSVSNNRQSGPVLAPSRFRIGDQEFEALPALLEFYKIHYLDTTTLIEPVSKARNANSNSTPAGAPQQVEEEFVRALFDFPGNDEEDLPFRKGDILRVLEKPEEQWWNAANQEGQIGMIPVPYVEKYRPGSPTTACPGTPGATPGQGGPAGGTDGIGSPLGNPLGEPGPYAQPVVSAQLPNLQNGPVYARAIQKRVPNAYDKTALALEVGDMVKVTKINVNGQWEGECK-GKQGHFPFTHVRL 303
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Medaka
Match: pik3r3b (phosphoinositide-3-kinase regulatory subunit 3 [Source:NCBI gene;Acc:101170665]) HSP 1 Score: 50.8322 bits (120), Expect = 1.276e-6 Identity = 29/85 (34.12%), Postives = 48/85 (56.47%), Query Frame = 2 Query: 200 DWYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDGWKIGNTE---FDSIESLLSHFSKVIIRQ 445 +WY+G++SR+E + + DGT+L+RD + + G L K NK I ++DG K G +E F+S+ L+SH+ + Q Sbjct: 296 EWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG-KYGFSEPLTFNSVVDLISHYRHESLAQ 379
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Medaka
Match: pik3r1 (phosphoinositide-3-kinase regulatory subunit 1 [Source:NCBI gene;Acc:101171597]) HSP 1 Score: 50.447 bits (119), Expect = 1.307e-6 Identity = 34/109 (31.19%), Postives = 56/109 (51.38%), Query Frame = 2 Query: 167 ILRNLMQNHVK----DWYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDGWKIGNTE---FDSIESLLSHFSKVIIRQSTLTNPAPK 472 ++ N M N++ +WY+G +SR+E + ADGT+L+RD + + G L K NK I ++DG K G ++ F S+ L++H+ R +L PK Sbjct: 27 VINNGMNNNMALQDAEWYWGEISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDG-KYGFSDPLTFSSVVELINHY-----RNESLAQYNPK 129
BLAST of Potassium channel tetramerization domain containing 1 vs. Planmine SMEST
Match: SMESG000067417.1 (SMESG000067417.1) HSP 1 Score: 506.138 bits (1302), Expect = 0.000e+0 Identity = 244/246 (99.19%), Postives = 245/246 (99.59%), Query Frame = 2 Query: 146 MNPKEYSILRNLMQNHVKDWYFGNLSRDEAQNSIFMEADGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDGWKIGNTEFDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQSSNDKTSLQQMVFKMQSRVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNINDLEV 883 MNPKEYSILRNLMQNHVKDWYFGNLSRDEAQNSIFME DGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDGWKIGN+EFDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQSSNDKTSLQQMVFKMQSRVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNINDLEV Sbjct: 1 MNPKEYSILRNLMQNHVKDWYFGNLSRDEAQNSIFMEGDGTYLIRDCNQILGGYVLLVKEKTQTNKYIISPYKDGWKIGNSEFDSIESLLSHFSKVIIRQSTLTNPAPKPFYRVLQTYHPKSDIELAVNECQFVRFVLKYDEKILCEHQLTKAIGWLPVNILKQSSNDKTSLQQMVFKMQSRVPFKTLAIKDRYPNVFDKSQLSVKVGDSLMVIDVLENGMLQTKNQFGKDGLVPFNIVNINDLEV 246 The following BLAST results are available for this feature:
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 4
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Potassium channel tetramerization domain containing 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Potassium channel tetramerization domain containing 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 2
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of Potassium channel tetramerization domain containing 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Potassium channel tetramerization domain containing 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30024416 ID=SMED30024416|Name=Potassium channel tetramerization domain containing 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1035bpback to top protein sequence of SMED30024416-orf-1 >SMED30024416-orf-1 ID=SMED30024416-orf-1|Name=SMED30024416-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=247bp MNPKEYSILRNLMQNHVKDWYFGNLSRDEAQNSIFMEADGTYLIRDCNQIback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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