RING-type domain-containing protein

Overview


Name	RING-type domain-containing protein
Smed ID	SMED30024395
Length (bp)	853

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of RING-type domain-containing protein (SMED30024395) t-SNE clustered cells

Violin plots show distribution of expression levels for RING-type domain-containing protein (SMED30024395) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of RING-type domain-containing protein (SMED30024395) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for RING-type domain-containing protein (SMED30024395) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30024395

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 8

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
neoblast	SMED30024395	h1SMcG0009919	dd_Smed_v4_1180_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30024395	h1SMcG0009919	dd_Smed_v4_1180_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30024395	h1SMcG0014086	Contig42679	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30024395	h1SMcG0014086	Contig42679	newmark_ests	PMID:29674431 Fincher et al., 2018
neoblast	SMED30024395	h1SMcG0014086	dd_Smed_v4_1180_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30024395	h1SMcG0014086	dd_Smed_v4_1180_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30024395	h1SMcG0009919	dd_Smed_v4_1180_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
epidermis	SMED30024395	h1SMcG0014086	dd_Smed_v4_1180_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: RNF126 (ring finger protein 126 [Source:HGNC Symbol;Acc:HGNC:21151])

HSP 1 Score: 116.316 bits (290), Expect = 3.407e-30
Identity = 69/248 (27.82%), Postives = 114/248 (45.97%), Query Frame = 3

Query:   33 ATINTDNYFCHKCNRD-VHISQDGKCVTCNDGFIERIESD----------NSMESDDDALNVFHIIRHI------------------------PSGSTTNETDGSFFITPRDHDNRNSVFGQLISNLF-----GGLLPLD-FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
            A+ +   YFCH C+ + V    D  C  C  GFIE +  +          ++  +D     + H+ +H+                        P G+  ++         RDH +R+ +  QL++ +        L P     S+P DY +     D  +T+++NQFE +GPPPA++  I+ L    +TE    +   C +C  DY +G+ V +LPC H +H  C+  WL +H +CP+CRK L+G +T
Sbjct:    4 ASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSTENGSAPSTAPTDQSRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPESRRERDHPSRHRIIQQLVNGIITPATIPSLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNT 251

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BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: RNF126 (ring finger protein 126 [Source:HGNC Symbol;Acc:HGNC:21151])

HSP 1 Score: 102.449 bits (254), Expect = 6.880e-25
Identity = 69/275 (25.09%), Postives = 114/275 (41.45%), Query Frame = 3

Query:   33 ATINTDNYFCHKCNRD-VHISQDGKCVTCNDGFIERIESD----------NSMESDDDALNVFHIIRHI------------------------PSGSTTNETDGSFFITPRDHDNRNSVFGQ-----------------------LISNLFGGLL---------PLD-FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
            A+ +   YFCH C+ + V    D  C  C  GFIE +  +          ++  +D     + H+ +H+                        P G+  ++         RDH +R+    +                       +I  L  G++         P     S+P DY +     D  +T+++NQFE +GPPPA++  I+ L    +TE    +   C +C  DY +G+ V +LPC H +H  C+  WL +H +CP+CRK L+G +T
Sbjct:    4 ASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSTENGSAPSTAPTDQSRPPLEHVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPESRRERDHPSRHRYGARQPRARLTTRRATGRHEGVPTLEGIIQQLVNGIITPATIPSLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNT 278

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BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: RNF115 (ring finger protein 115 [Source:HGNC Symbol;Acc:HGNC:18154])

HSP 1 Score: 98.5969 bits (244), Expect = 1.961e-23
Identity = 48/125 (38.40%), Postives = 68/125 (54.40%), Query Frame = 3

Query:  333 FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLESHDHIAQSS---SND 686
              S+P DY +     D  VT+++ Q E +GPPPA++  I  L    +T+        C +C  DY V +EV +LPC H +H  C+  WL  H TCP+CRK L+G D+  +S    A +S   SND
Sbjct:  171 LHSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLECPVCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQSQSTEASASNRFSND 295

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BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: RLIM (ring finger protein, LIM domain interacting [Source:HGNC Symbol;Acc:HGNC:13429])

HSP 1 Score: 69.707 bits (169), Expect = 9.036e-13
Identity = 31/84 (36.90%), Postives = 52/84 (61.90%), Query Frame = 3

Query:  396 IMNQFEQSGPPPANEADIEKLQVTKITE--ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDL--SGN 635
            ++N+ +   P    +  I+ L +    E  A  TCS+C+++Y  G+++ +LPC H+YHV C+  WL ++ TCPICR+ +  SGN
Sbjct:  536 LLNEDDDDQPRGLTKEQIDNLAMRSFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAVLASGN 619

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Query:  396 IMNQFEQSGPPPANEADIEKLQVTKITE--ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDL--SGN 635
            ++N+ +   P    +  I+ L +    E  A  TCS+C+++Y  G+++ +LPC H+YHV C+  WL ++ TCPICR+ +  SGN
Sbjct:  536 LLNEDDDDQPRGLTKEQIDNLAMRSFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAVLASGN 619

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BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: H10E21.5 (pep chromosome:WBcel235:III:20531:23962:-1 gene:WBGene00019185.1 transcript:H10E21.5.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:H10E21.5)

HSP 1 Score: 61.6178 bits (148), Expect = 1.645e-10
Identity = 21/50 (42.00%), Postives = 33/50 (66.00%), Query Frame = 3

Query:  477 EANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDL 626
            E    C++CL  Y++ D +  LPC+H YH  C+  WL++H TCP+C+ D+
Sbjct:  222 ELQSDCAVCLDPYQLQDVIRLLPCKHIYHKSCIDPWLLEHRTCPMCKNDI 271

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BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: C01G6.4 (pep chromosome:WBcel235:II:9271265:9273042:-1 gene:WBGene00007226.1 transcript:C01G6.4.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C01G6.4)

HSP 1 Score: 54.6842 bits (130), Expect = 5.523e-9
Identity = 19/44 (43.18%), Postives = 30/44 (68.18%), Query Frame = 3

Query:  483 NDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPIC 614
            ++ C+IC+ D+E G+ +  LPC H +H +C+  WL+K  TCP C
Sbjct:   92 SNECAICMIDFEPGERIRFLPCMHSFHQECVDEWLMKSFTCPSC 135

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BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: C18B12.4 (pep chromosome:WBcel235:X:15036662:15040602:-1 gene:WBGene00007666.1 transcript:C18B12.4.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C18B12.4)

HSP 1 Score: 56.225 bits (134), Expect = 8.060e-9
Identity = 27/88 (30.68%), Postives = 50/88 (56.82%), Query Frame = 3

Query:  435 NEADIEKLQVTKITEAND--TCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIK-HGTCPICRKDLSGNDTRLESHDHIAQSSSNDP 689
            ++ +++K+ V K    +D  TC+ICL  +  G+++  LPC+H +H  C+  WL +    CP+C++ + G D+  E   +   S+S  P
Sbjct:  226 SKRNLKKIPVKKYRLGDDPDTCAICLESFASGEKLRHLPCRHVFHCNCIDVWLTQTRKICPLCKRKI-GTDSDSECSTNDLASTSQGP 312

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BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: toe-4 (Target Of ERK kinase MPK-1 [Source:UniProtKB/TrEMBL;Acc:Q9XUM8])

HSP 1 Score: 55.8398 bits (133), Expect = 1.344e-8
Identity = 20/50 (40.00%), Postives = 34/50 (68.00%), Query Frame = 3

Query:  477 EANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDL 626
            E  DTC++CLS +E G+ + +L C H +H +C+  WL  +  CP+CR+++
Sbjct:  428 EDEDTCTVCLSSFEDGESIQKLRCNHVFHPECIYKWLDINKRCPMCREEI 477

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BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: plr-1 (Probable E3 ubiquitin-protein ligase plr-1 [Source:UniProtKB/Swiss-Prot;Acc:Q9U2B7])

HSP 1 Score: 53.1434 bits (126), Expect = 8.101e-8
Identity = 20/49 (40.82%), Postives = 31/49 (63.27%), Query Frame = 3

Query:  480 ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDL 626
            A + C ICL +YE G E+  L C H++H +C+  WL+    CP+C+ D+
Sbjct:  313 AQERCVICLEEYEEGTELRVLFCGHEFHPKCVDPWLLSKRRCPLCQFDV 361

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BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: Iru (gene:FBgn0037653 transcript:FBtr0081965)

HSP 1 Score: 95.9005 bits (237), Expect = 2.431e-22
Identity = 46/109 (42.20%), Postives = 63/109 (57.80%), Query Frame = 3

Query:  333 FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKIT--EANDT--CSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLS--GNDT 641
            F  +P DY +  +  D  VT+++NQ E SGPPP +   I ++   +I   E N    CSIC  D+++ + V +LPC H YH  C+  WL  H TCPICRK L+  GND 
Sbjct:  196 FMGNPGDYAWGREGLDTIVTQMLNQMETSGPPPLSAQRINEIPNVQINAEEVNRKIQCSICWDDFKIDETVRKLPCSHLYHENCIVPWLNLHSTCPICRKSLADDGNDA 304

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BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: CG7694 (gene:FBgn0038627 transcript:FBtr0290211)

HSP 1 Score: 59.3066 bits (142), Expect = 1.028e-10
Identity = 33/104 (31.73%), Postives = 54/104 (51.92%), Query Frame = 3

Query:  387 VTRIMNQFEQS-GPPPANEADIEKLQVTKITEAND----TCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLESHDHIAQSSSN 683
            V  IMN  +     P A++  I +L V +I ++++     CS+C    E G +   LPC+H++H +C+  WL K  +CP+CR +L  +D   E      Q  +N
Sbjct:   30 VLAIMNGIDMEIEVPEASKRAILELPVHEIVKSDEGGDLECSVCKEPAEEGQKYRILPCKHEFHEECILLWLKKTNSCPLCRYELETDDPVYEELRRFRQDEAN 133

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BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: CG7694 (gene:FBgn0038627 transcript:FBtr0083632)

HSP 1 Score: 59.3066 bits (142), Expect = 1.028e-10
Identity = 33/104 (31.73%), Postives = 54/104 (51.92%), Query Frame = 3

Query:  387 VTRIMNQFEQS-GPPPANEADIEKLQVTKITEAND----TCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLESHDHIAQSSSN 683
            V  IMN  +     P A++  I +L V +I ++++     CS+C    E G +   LPC+H++H +C+  WL K  +CP+CR +L  +D   E      Q  +N
Sbjct:   30 VLAIMNGIDMEIEVPEASKRAILELPVHEIVKSDEGGDLECSVCKEPAEEGQKYRILPCKHEFHEECILLWLKKTNSCPLCRYELETDDPVYEELRRFRQDEAN 133

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BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: CG7694 (gene:FBgn0038627 transcript:FBtr0344291)

HSP 1 Score: 59.3066 bits (142), Expect = 1.028e-10
Identity = 33/104 (31.73%), Postives = 54/104 (51.92%), Query Frame = 3

Query:  387 VTRIMNQFEQS-GPPPANEADIEKLQVTKITEAND----TCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLESHDHIAQSSSN 683
            V  IMN  +     P A++  I +L V +I ++++     CS+C    E G +   LPC+H++H +C+  WL K  +CP+CR +L  +D   E      Q  +N
Sbjct:   30 VLAIMNGIDMEIEVPEASKRAILELPVHEIVKSDEGGDLECSVCKEPAEEGQKYRILPCKHEFHEECILLWLKKTNSCPLCRYELETDDPVYEELRRFRQDEAN 133

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BLAST of RING-type domain-containing protein vs. Ensembl Fly
Match: gol (gene:FBgn0004919 transcript:FBtr0300179)

HSP 1 Score: 59.6918 bits (143), Expect = 8.225e-10
Identity = 21/48 (43.75%), Postives = 34/48 (70.83%), Query Frame = 3

Query:  483 NDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDL 626
            +D C+IC+  Y+  D +  LPC+H++H  C+  WLI+H TCP+C+ D+
Sbjct:  300 SDCCAICIEAYKPTDTIRILPCKHEFHKNCIDPWLIEHRTCPMCKLDV 347

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BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: rnf126 (ring finger protein 126 [Source:ZFIN;Acc:ZDB-GENE-070209-292])

HSP 1 Score: 102.834 bits (255), Expect = 3.312e-25
Identity = 44/107 (41.12%), Postives = 64/107 (59.81%), Query Frame = 3

Query:  333 FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
              S+P DY +     D  +T+++NQFE +GPPPA++  I+ L   +I +    A   C +C  DY  G+ V +LPC H +H  C+  WL +H TCP+CRK LSG +T
Sbjct:  169 LHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKDKIKSLPTVQIKQEHVGAGLECPVCKEDYSAGENVRQLPCNHLFHNDCIVPWLEQHDTCPVCRKSLSGQNT 275

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BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: rnf115 (ring finger protein 115 [Source:ZFIN;Acc:ZDB-GENE-061215-82])

HSP 1 Score: 100.523 bits (249), Expect = 2.524e-24
Identity = 49/137 (35.77%), Postives = 74/137 (54.01%), Query Frame = 3

Query:  282 VFGQLISNLFG-----GLLPLDF----RSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLES 653
            +  Q ++ LF      G  P+ +     S+P DY +     D  +T+++ QFE +GPPPA +  I  L    IT+     N  C +C  DY VG+ V +LPC H +H  C+  WL  H TCP+CRK L+G+++  +S
Sbjct:  155 IVQQFLAGLFANSGVPGSPPVSWTSMLHSNPGDYAWGQGGLDAVITQLLGQFENTGPPPAEKEKISSLPTVIITQEHTDCNMECPVCKEDYTVGEPVRQLPCNHFFHSDCIVPWLELHDTCPVCRKSLNGDESGTQS 291

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BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: si:ch211-81a5.1 (si:ch211-81a5.1 [Source:ZFIN;Acc:ZDB-GENE-060503-608])

HSP 1 Score: 92.8189 bits (229), Expect = 1.167e-21
Identity = 41/106 (38.68%), Postives = 56/106 (52.83%), Query Frame = 3

Query:  333 FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITEANDTC----SICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGND 638
              S+P DY +     D  VT+++ Q E SGPPPA +  I  L    I+     C     +C  ++ VG+ V +LPC H +H  C+  WL  H TCP+CRK L G D
Sbjct:  145 LHSNPGDYAWGQGGLDAVVTQLLGQSENSGPPPAEKEMISSLPTVSISSEQAACRLECPVCREEFSVGESVRQLPCLHYFHSSCIVPWLQLHDTCPVCRKSLDGED 250

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BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: si:ch211-81a5.1 (si:ch211-81a5.1 [Source:ZFIN;Acc:ZDB-GENE-060503-608])

HSP 1 Score: 92.8189 bits (229), Expect = 1.423e-21
Identity = 41/106 (38.68%), Postives = 56/106 (52.83%), Query Frame = 3

Query:  333 FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITEANDTC----SICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGND 638
              S+P DY +     D  VT+++ Q E SGPPPA +  I  L    I+     C     +C  ++ VG+ V +LPC H +H  C+  WL  H TCP+CRK L G D
Sbjct:  168 LHSNPGDYAWGQGGLDAVVTQLLGQSENSGPPPAEKEMISSLPTVSISSEQAACRLECPVCREEFSVGESVRQLPCLHYFHSSCIVPWLQLHDTCPVCRKSLDGED 273

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BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: si:ch211-59o9.10 (si:ch211-59o9.10 [Source:ZFIN;Acc:ZDB-GENE-101206-1])

HSP 1 Score: 69.707 bits (169), Expect = 4.649e-13
Identity = 33/98 (33.67%), Postives = 54/98 (55.10%), Query Frame = 3

Query:  357 IFSDQSFDNFVTRIMNQFEQSGPPPAN---EADIEKLQVTKI----TEANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLS 629
            +F+D   +N+   +  + +Q      N   +A+IE+L +       +     C IC S+Y+ G+ +  LPC H YHV+C+  WL ++ TCPICR D+S
Sbjct:  371 LFNDSQGNNYEALLAFEEQQGAVMAKNTLSKAEIERLPIKTYDPTHSAGKTDCQICFSEYKAGERLRMLPCLHDYHVKCIDRWLKENATCPICRADVS 468

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BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: rnf126 (ring finger protein 126 [Source:NCBI gene;Acc:448402])

HSP 1 Score: 108.612 bits (270), Expect = 4.780e-27
Identity = 50/119 (42.02%), Postives = 71/119 (59.66%), Query Frame = 3

Query:  297 ISNLFGGLLPLDFRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
            +  L GG+L     S+P DY +     D  +T+++NQFE +GPPPA+   I+ L   +ITE    +   C +C  DY VG+ V +LPC H +H  C+  WL +H TCP+CRK LSG +T
Sbjct:  180 VPTLEGGVL----HSNPMDYAWGANGLDTIITQLLNQFENTGPPPADTEKIQALPTIQITEEHVGSGLECPVCKEDYTVGESVRQLPCNHLFHNDCIIPWLEQHDTCPVCRKSLSGQNT 294

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: rnf126 (ring finger protein 126 [Source:NCBI gene;Acc:448402])

HSP 1 Score: 107.071 bits (266), Expect = 2.353e-26
Identity = 51/120 (42.50%), Postives = 72/120 (60.00%), Query Frame = 3

Query:  297 ISNLFGGLLPLD-FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
            +SNL  G+ P     S+P DY +     D  +T+++NQFE +GPPPA+   I+ L   +ITE    +   C +C  DY VG+ V +LPC H +H  C+  WL +H TCP+CRK LSG +T
Sbjct:  185 MSNL--GVGPWGVLHSNPMDYAWGANGLDTIITQLLNQFENTGPPPADTEKIQALPTIQITEEHVGSGLECPVCKEDYTVGESVRQLPCNHLFHNDCIIPWLEQHDTCPVCRKSLSGQNT 302

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: stxbp3 (syntaxin binding protein 3 [Source:Xenbase;Acc:XB-GENE-963836])

HSP 1 Score: 97.8265 bits (242), Expect = 1.632e-23
Identity = 49/156 (31.41%), Postives = 78/156 (50.00%), Query Frame = 3

Query:  270 NRNSVFGQLISNLFGGLL----------PLDF----RSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITEANDT----CSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLESHDHIAQSSSN 683
            +R+     +I  +F G+           PL +     S+P DY +     D+ VT+++ Q E +GPPPA++  I  L    +T         C +C  DY + ++V +LPC H +H  C+  WL  H TCP+CRK L+G D+  ++    A  S+N
Sbjct:  100 DRSPAIEGIIQQIFAGVFANPPFPGSPHPLSWSGMLHSNPGDYAWGQSGLDSIVTQLLGQLENTGPPPADKDKIVSLPTVTVTREQVAMGLECPVCKEDYAIEEQVRQLPCNHFFHGDCIVPWLELHDTCPVCRKSLNGEDSTRQAPSSEASGSNN 255

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BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: stxbp3 (syntaxin binding protein 3 [Source:Xenbase;Acc:XB-GENE-963836])

HSP 1 Score: 97.4413 bits (241), Expect = 3.007e-23
Identity = 49/156 (31.41%), Postives = 78/156 (50.00%), Query Frame = 3

Query:  270 NRNSVFGQLISNLFGGLL----------PLDF----RSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITEANDT----CSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLESHDHIAQSSSN 683
            +R+     +I  +F G+           PL +     S+P DY +     D+ VT+++ Q E +GPPPA++  I  L    +T         C +C  DY + ++V +LPC H +H  C+  WL  H TCP+CRK L+G D+  ++    A  S+N
Sbjct:  111 DRSPAIEGIIQQIFAGVFANPPFPGSPHPLSWSGMLHSNPGDYAWGQSGLDSIVTQLLGQLENTGPPPADKDKIVSLPTVTVTREQVAMGLECPVCKEDYAIEEQVRQLPCNHFFHGDCIVPWLELHDTCPVCRKSLNGEDSTRQAPSSEASGSNN 266

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: stxbp3 (syntaxin binding protein 3 [Source:Xenbase;Acc:XB-GENE-963836])

HSP 1 Score: 97.0561 bits (240), Expect = 5.005e-23
Identity = 49/156 (31.41%), Postives = 78/156 (50.00%), Query Frame = 3

Query:  270 NRNSVFGQLISNLFGGLL----------PLDF----RSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITEANDT----CSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLESHDHIAQSSSN 683
            +R+     +I  +F G+           PL +     S+P DY +     D+ VT+++ Q E +GPPPA++  I  L    +T         C +C  DY + ++V +LPC H +H  C+  WL  H TCP+CRK L+G D+  ++    A  S+N
Sbjct:  127 DRSPAIEGIIQQIFAGVFANPPFPGSPHPLSWSGMLHSNPGDYAWGQSGLDSIVTQLLGQLENTGPPPADKDKIVSLPTVTVTREQVAMGLECPVCKEDYAIEEQVRQLPCNHFFHGDCIVPWLELHDTCPVCRKSLNGEDSTRQAPSSEASGSNN 282

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BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Rnf126 (ring finger protein 126 [Source:MGI Symbol;Acc:MGI:1917544])

HSP 1 Score: 103.605 bits (257), Expect = 2.087e-25
Identity = 45/114 (39.47%), Postives = 68/114 (59.65%), Query Frame = 3

Query:  315 GLLPLD-FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
            GL P     S+P DY +     D  +T+++NQFE +GPPPA++  I+ L    +TE    +   C +C  DY +G+ V +LPC H +H  C+  WL +H +CP+CRK L+G +T
Sbjct:  167 GLGPWGVLHSNPMDYAWGANGLDTIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKEDYALGESVRQLPCNHLFHDSCIVPWLEQHDSCPVCRKSLTGQNT 280

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Rnf115 (ring finger protein 115 [Source:MGI Symbol;Acc:MGI:1915095])

HSP 1 Score: 97.8265 bits (242), Expect = 2.371e-23
Identity = 69/273 (25.27%), Postives = 106/273 (38.83%), Query Frame = 3

Query:   54 YFCHKCNRDVHIS-QDGKCVTCNDGFIERIESDNSMESDDDALNVFHIIRHIPSGSTTNETDGSFFI---------TPRDHDNRNSVFGQ-------------------------------------LISNLFGGLL----------PLDF----RSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLESHDHIAQSS 677
            +FCH C  +V+    +  C  C+ GFIE +  D+S      +        H       +  D + F+          P D DNR +  G                                      +I  +F G            P  +     S+P DY +     D  VT+++ Q E +GPPPA++  I  L    +T+        C +C  DY V ++V +LPC H +H  C+  WL  H TCP+CRK L+G D+  ++    A +S
Sbjct:   20 FFCHFCKGEVNPKLPEYICPRCDSGFIEEVTDDSSFLGGGGSRTDNSTATHF--AELWDHLDHTMFLQDFRPFLSSNPLDQDNRANERGHQTHTDFWGPSRPPRLPMTRRYRSRGSTRPDRSPAIEGIIQQIFAGFFANSAIPGSPHPFSWSGMLHSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVNTGLECPVCKEDYTVEEKVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQTQSSEASAS 290

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Rnf181 (ring finger protein 181 [Source:MGI Symbol;Acc:MGI:1913760])

HSP 1 Score: 72.0182 bits (175), Expect = 2.056e-15
Identity = 33/85 (38.82%), Postives = 48/85 (56.47%), Query Frame = 3

Query:  408 FEQSGPPPANEADIEKLQVTKITEAND--TCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLESH 656
            +E   PPPA +A +E L  T I+ A     C +CL ++E  + V E+PC H +H  C+  WL K  +CP+CR +L  +D   E H
Sbjct:   11 WEHHLPPPAAKAVVESLPRTVISSAKADLKCPVCLLEFEAEETVIEMPCHHLFHSNCILPWLSKTNSCPLCRHELPTDDDSYEEH 95

[Close]

Query:  408 FEQSGPPPANEADIEKLQVTKITEAND--TCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLESH 656
            +E   PPPA +A +E L  T I+ A     C +CL ++E  + V E+PC H +H  C+  WL K  +CP+CR +L  +D   E H
Sbjct:   11 WEHHLPPPAAKAVVESLPRTVISSAKADLKCPVCLLEFEAEETVIEMPCHHLFHSNCILPWLSKTNSCPLCRHELPTDDDSYEEH 95

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Rnf181 (ring finger protein 181 [Source:MGI Symbol;Acc:MGI:1913760])

HSP 1 Score: 72.0182 bits (175), Expect = 4.963e-15
Identity = 33/85 (38.82%), Postives = 48/85 (56.47%), Query Frame = 3

Query:  408 FEQSGPPPANEADIEKLQVTKITEAND--TCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLESH 656
            +E   PPPA +A +E L  T I+ A     C +CL ++E  + V E+PC H +H  C+  WL K  +CP+CR +L  +D   E H
Sbjct:   58 WEHHLPPPAAKAVVESLPRTVISSAKADLKCPVCLLEFEAEETVIEMPCHHLFHSNCILPWLSKTNSCPLCRHELPTDDDSYEEH 142

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6DIP3|RN126_XENTR (E3 ubiquitin-protein ligase RNF126 OS=Xenopus tropicalis OX=8364 GN=rnf126 PE=2 SV=1)

HSP 1 Score: 106.686 bits (265), Expect = 9.096e-26
Identity = 51/120 (42.50%), Postives = 72/120 (60.00%), Query Frame = 3

Query:  297 ISNLFGGLLPLD-FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
            +SNL  G+ P     S+P DY +     D  +T+++NQFE +GPPPA+   I+ L   +ITE    +   C +C  DY VG+ V +LPC H +H  C+  WL +H TCP+CRK LSG +T
Sbjct:  159 MSNL--GVGPWGVLHSNPMDYAWGANGLDTIITQLLNQFENTGPPPADTEKIQALPTIQITEEHVGSGLECPVCKEDYTVGESVRQLPCNHLFHNDCIIPWLEQHDTCPVCRKSLSGQNT 276

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6IRP0|R126B_XENLA (E3 ubiquitin-protein ligase RNF126-B OS=Xenopus laevis OX=8355 GN=rnf126-b PE=2 SV=1)

HSP 1 Score: 105.531 bits (262), Expect = 2.696e-25
Identity = 51/120 (42.50%), Postives = 72/120 (60.00%), Query Frame = 3

Query:  297 ISNLFGGLLPLD-FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITEAND----TCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
            +SNL  G+ P     S+P DY +     D  +T+++NQFE +GPPPA+   I+ L   +ITE +      C +C  DY VG+ V +LPC H +H  C+  WL +H TCP+CRK LSG +T
Sbjct:  160 MSNL--GVGPWGVLHSNPMDYAWGANGLDTIITQLLNQFENTGPPPADTDKIQALPTIQITEEHVGFGLECPVCKEDYTVGESVRQLPCNHLFHNDCIIPWLEQHDTCPVCRKSLSGQNT 277

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q7T0Q3|R126A_XENLA (E3 ubiquitin-protein ligase RNF126-A OS=Xenopus laevis OX=8355 GN=rnf126-a PE=2 SV=1)

HSP 1 Score: 105.531 bits (262), Expect = 3.113e-25
Identity = 51/120 (42.50%), Postives = 72/120 (60.00%), Query Frame = 3

Query:  297 ISNLFGGLLPLD-FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
            +SNL  G+ P     S+P DY +     D  +T+++NQFE +GPPPA+   I+ L   +ITE    +   C +C  DY VG+ V +LPC H +H  C+  WL +H TCP+CRK LSG +T
Sbjct:  160 MSNL--GVGPWGVLHSNPMDYAWGANGLDTIITQLLNQFENTGPPPADNEKIQALPTIQITEEHVGSGLECPVCKEDYTVGECVRQLPCNHLFHNDCIIPWLEQHDTCPVCRKSLSGQNT 277

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q91YL2|RN126_MOUSE (E3 ubiquitin-protein ligase RNF126 OS=Mus musculus OX=10090 GN=Rnf126 PE=1 SV=1)

HSP 1 Score: 103.605 bits (257), Expect = 1.459e-24
Identity = 45/114 (39.47%), Postives = 68/114 (59.65%), Query Frame = 3

Query:  315 GLLPLD-FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
            GL P     S+P DY +     D  +T+++NQFE +GPPPA++  I+ L    +TE    +   C +C  DY +G+ V +LPC H +H  C+  WL +H +CP+CRK L+G +T
Sbjct:  167 GLGPWGVLHSNPMDYAWGANGLDTIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKEDYALGESVRQLPCNHLFHDSCIVPWLEQHDSCPVCRKSLTGQNT 280

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q0II22|RN126_BOVIN (E3 ubiquitin-protein ligase RNF126 OS=Bos taurus OX=9913 GN=RNF126 PE=2 SV=1)

HSP 1 Score: 102.834 bits (255), Expect = 2.511e-24
Identity = 48/120 (40.00%), Postives = 71/120 (59.17%), Query Frame = 3

Query:  297 ISNLFGGLLPLD-FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
            I NL  GL P     S+P DY +     D  +T+++NQFE +GPPPA++  I+ L    +TE    +   C +C  DY +G+ V +LPC H +H  C+  WL +H +CP+CRK L+G +T
Sbjct:  164 IPNL--GLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYGLGEHVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNT 281

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: G4LWM6 (Zinc finger protein, putative OS=Schistosoma mansoni OX=6183 GN=Smp_049970.5 PE=4 SV=1)

HSP 1 Score: 123.635 bits (309), Expect = 7.199e-30
Identity = 82/256 (32.03%), Postives = 119/256 (46.48%), Query Frame = 3

Query:   30 MATINT-DNYFCHKCNRDVHIS-QDGKCVTCNDGFIERIESDNSMESDDDALNVFHIIRHIPSGSTTNETDGSFFITPRD----------------------------HDNRNSVFGQLI--SNLFGGLLPLD-----FR-----------SDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITEAN----DTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
            MAT ++ D+Y+CH C  +V  + QD  C  C+ GFIE I   + + S+   L+   +I  +  GS ++     +F  PRD                               R  V+ ++    + F   + L      FR            D  +++F+   FD F+T +MN+  Q GPPPA E+ I  L    +TE        CSIC  D++  + V  LPC H YH  C+ TWL +HGTCP+CRKDLSG+DT
Sbjct:    1 MATGSSGDSYYCHSCEAEVVPNLQDFTCSACHSGFIEAISPGSGLSSNPTELDAMQMIGQLFGGSLSDNF-VRYFAAPRDDLSSTDDESLERESLSRRSRRSTRNSNHRSTRERVYTRVPDGRHAFSTRIQLSSVDHPFRLPFLSNFGSADGDMQNFVFNRAMFDQFITVLMNEL-QVGPPPAPESAIADLPTISLTEEQALKLGICSICFDDFKESESVIRLPCAHTYHQTCVTTWLKQHGTCPVCRKDLSGHDT 254

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A2C9L8K4 (RING-type domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106065911 PE=4 SV=1)

HSP 1 Score: 121.709 bits (304), Expect = 3.262e-29
Identity = 80/240 (33.33%), Postives = 113/240 (47.08%), Query Frame = 3

Query:   48 DNYFCHKCNRDVHISQDG-KCVTCNDGFIERIE-----SDNSMESDDDALNVFHII---------RH---IPSGSTTNE----------------TDGSFFIT---PRDHDNRNSVFGQLISNLFGG--LLPLDFRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKI----TEANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGND 638
            + +FCH+C R V I+     C  CN GFIE +E     S  S+ + D A  +  +          RH    PS +  NE                 +  F  T   P  H   N V  +L ++L GG    P+    +P DY +     D  +++++N  E +G PPA    IE L+  +I     E    CSIC+ D+E+  EV +LPC H YH +C+  WL  HGTCP+CRKDL+G D
Sbjct:   11 NTFFCHQCMRVVVINIPAYTCSRCNSGFIEELERPQPSSSPSVHTSDTAAQISQVFPIFANVGTSRHRLNTPSVTRINEDFDVDLSDEDEIRSVGPNAVFHFTEPSPNLHGIINYVIQRLGTDLAGGGGRNPIILHGNPGDYAWGAGGLDAIISQLLNHLEGTGAPPAQREKIENLERVRINQTHIENTLQCSICMDDFELDLEVRKLPCDHLYHPECIIKWLEMHGTCPVCRKDLNGID 250

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: T1KM53 (RING-type domain-containing protein OS=Tetranychus urticae OX=32264 GN=107365553 PE=4 SV=1)

HSP 1 Score: 120.168 bits (300), Expect = 8.851e-29
Identity = 68/202 (33.66%), Postives = 107/202 (52.97%), Query Frame = 3

Query:   54 YFCHKCNRDVH-ISQDGKCVTCNDGFIERIESDNSME-SDDDALNVFHIIRHIPSGSTTNETDGSFFITPRDHDNRNSVFGQLISNLFGGLLPL--DFRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKI----TEANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGN 635
            YFCHKCN++++ +  + KC  C +GFIE + SD +++ S DD+ ++ +  R       T   +    +     D + +  G     +F   +P       +P DY +  Q  D  +T+++N  E +GPPP  + +IEKL    I     + N  C++C+ DY++ + V  LPC H YH  C+  WL  HGTCPICRK L+ N
Sbjct:   13 YFCHKCNQEINPVLPEFKCPGCREGFIEELTSDANLDISSDDSEHLENYERF----EDTRAGEILRVLQLFSGDQQANQRGNRGRGMFEMAIPYLQILHGNPGDYAWGSQGLDTIITQLLNTIENNGPPPMPKEEIEKLPTVNICQDNVDKNLQCTVCMEDYKLDEPVRVLPCNHVYHNDCIVPWLEMHGTCPICRKLLNEN 210

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: G4LWM7 (Zinc finger protein, putative OS=Schistosoma mansoni OX=6183 GN=Smp_049970.4 PE=4 SV=1)

HSP 1 Score: 120.168 bits (300), Expect = 1.218e-28
Identity = 83/256 (32.42%), Postives = 119/256 (46.48%), Query Frame = 3

Query:   30 MATINT-DNYFCHKCNRDVHIS-QDGKCVTCNDGFIERIESDNSMESDDDALNVFHIIRHIPSGSTTNETDGSFFITPRD----------------------------HDNRNSVFGQLI--SNLFGGLLPLD-----FR-----------SDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITEAN----DTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
            MAT ++ D+Y+CH C  +V  + QD  C  C+ GFIE I S   + S+   L+   +I  +  GS ++     +F  PRD                               R  V+ ++    + F   + L      FR            D  +++F+   FD F+T +MN+  Q GPPPA E+ I  L    +TE        CSIC  D++  + V  LPC H YH  C+ TWL +HGTCP+CRKDLSG+DT
Sbjct:    1 MATGSSGDSYYCHSCEAEVVPNLQDFTCSACHSGFIEAI-SPGGLSSNPTELDAMQMIGQLFGGSLSDNF-VRYFAAPRDDLSSTDDESLERESLSRRSRRSTRNSNHRSTRERVYTRVPDGRHAFSTRIQLSSVDHPFRLPFLSNFGSADGDMQNFVFNRAMFDQFITVLMNEL-QVGPPPAPESAIADLPTISLTEEQALKLGICSICFDDFKESESVIRLPCAHTYHQTCVTTWLKQHGTCPVCRKDLSGHDT 253

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A3R7FL85 (E3 ubiquitin-protein ligase OS=Clonorchis sinensis OX=79923 GN=RNF126 PE=4 SV=1)

HSP 1 Score: 117.087 bits (292), Expect = 2.032e-28
Identity = 53/110 (48.18%), Postives = 72/110 (65.45%), Query Frame = 3

Query:  333 FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITEAN----DTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLE 650
             + D  DY  +   F+N +  + NQ    GPPPA+EA I++L V K+TE +     TCSIC  DY+V +EV +LPCQH YH  C+ TWL +H TCP+CRKDL+G DT ++
Sbjct:   64 IQGDIRDYALNQGMFENLLALLTNQL-HVGPPPASEATIQQLPVQKLTEDSVAQYKTCSICFEDYQVSEEVMQLPCQHVYHTTCVTTWLKQHATCPVCRKDLNGRDTSMD 172

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: rnf126 (ring finger protein 126 [Source:ZFIN;Acc:ZDB-GENE-070209-292])

HSP 1 Score: 107.071 bits (266), Expect = 8.182e-27
Identity = 46/107 (42.99%), Postives = 64/107 (59.81%), Query Frame = 3

Query:  333 FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
              S+P DY +     D  +T+++NQFE +GPPPA+   I+ L   +ITE    A   C +C  DY  G+ V +LPC H +H  C+  WL +H TCP+CRK LSG +T
Sbjct:  166 LHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADREKIKSLPTVQITEEHVGAGLECPVCKEDYSAGESVRQLPCNHLFHNDCIVPWLEQHDTCPVCRKSLSGQNT 272

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: rnf126 (ring finger protein 126 [Source:ZFIN;Acc:ZDB-GENE-070209-292])

HSP 1 Score: 107.457 bits (267), Expect = 1.441e-26
Identity = 48/114 (42.11%), Postives = 67/114 (58.77%), Query Frame = 3

Query:  315 GLLPLD-FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
            G+ P     S+P DY +     D  +T+++NQFE +GPPPA+   I+ L   +ITE    A   C +C  DY  G+ V +LPC H +H  C+  WL +H TCP+CRK LSG +T
Sbjct:  226 GMGPWGMLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADREKIKSLPTVQITEEHVGAGLECPVCKEDYSAGESVRQLPCNHLFHNDCIVPWLEQHDTCPVCRKSLSGQNT 339

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: rnf126 (ring finger protein 126 [Source:ZFIN;Acc:ZDB-GENE-070209-292])

HSP 1 Score: 107.071 bits (266), Expect = 1.750e-26
Identity = 46/105 (43.81%), Postives = 64/105 (60.95%), Query Frame = 3

Query:  339 SDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
            S+P DY +     D  +T+++NQFE +GPPPA+   I+ L   +ITE    A   C +C  DY  G+ V +LPC H +H  C+  WL +H TCP+CRK LSG +T
Sbjct:  221 SNPMDYAWGANGLDAIITQLLNQFENTGPPPADREKIKSLPTVQITEEHVGAGLECPVCKEDYSAGESVRQLPCNHLFHNDCIVPWLEQHDTCPVCRKSLSGQNT 325

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: rnf115 (ring finger protein 115 [Source:NCBI gene;Acc:107197307])

HSP 1 Score: 100.138 bits (248), Expect = 2.818e-24
Identity = 48/133 (36.09%), Postives = 72/133 (54.14%), Query Frame = 3

Query:  282 VFGQLISNLFG-----GLLPLDF----RSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
            +  Q ++ LF      G  PL +     S+P DY +     D  +T+++ QFE +GPPPA +  I  L    +++    ++  C +C  DY VG+ V +LPC H +H  C+  WL  H TCP+CRK LSG D+
Sbjct:  155 IVQQFLAGLFANSGVPGSPPLSWTGMLHSNPGDYAWGQGGLDAVITQLLGQFENTGPPPAEKEKISSLPTVIVSQEQADSSMECPVCKEDYTVGEPVRQLPCNHFFHSDCIVPWLELHDTCPVCRKSLSGEDS 287

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: si:ch211-81a5.1 (si:ch211-81a5.1 [Source:ZFIN;Acc:ZDB-GENE-060503-608])

HSP 1 Score: 95.9005 bits (237), Expect = 7.535e-23
Identity = 43/122 (35.25%), Postives = 64/122 (52.46%), Query Frame = 3

Query:  324 PLDFRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITEANDTC----SICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLESHDHIAQSS 677
            P    S+P DY +    FD  +T+++ Q E +GPPPA +  I  L    ++     C     +C  +Y VG+ V +LPC H +H  C+  WL  H TCP+CRK L+G D   +S     ++S
Sbjct:  149 PGTLHSNPGDYAWGQGGFDAVITQLLGQSEIAGPPPAEKEMISSLPTVHVSSEQAACRLECPVCREEYSVGESVRQLPCLHCFHSDCIVPWLQLHDTCPVCRKSLNGEDHSFQSQPAPQETS 270

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: rnf126 (ring finger protein 126 [Source:ZFIN;Acc:ZDB-GENE-070209-292])

HSP 1 Score: 106.301 bits (264), Expect = 2.903e-27
Identity = 53/157 (33.76%), Postives = 82/157 (52.23%), Query Frame = 3

Query:  216 STTNETDGSFFITPRDHDNRNSVFGQLISNLFGGLLPLDF------RSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKIT----EANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLESH 656
            ST+ ++ G+ F+  + H+ R      +I +L G  L   F       SDP DY++     D  +T+++ Q + SGPPPA++  I  +    I+    E    CS+C  D++ G++  +LPC+H YH  C+  WL  H TCP+CR  LSG  T    H
Sbjct:  125 STSRDSAGNTFL--QTHNGRAPSVEGIIQHLLGSFLGRQFAPWGALHSDPGDYVWGVNGIDQIITQLLGQLDNSGPPPADKDKIMAIPTISISSEQVECGLECSVCKEDFDEGEKARQLPCKHIYHTDCIIPWLEMHDTCPVCRTSLSGESTATAQH 279

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: RNF115 (ring finger protein 115 [Source:HGNC Symbol;Acc:HGNC:18154])

HSP 1 Score: 92.8189 bits (229), Expect = 1.519e-22
Identity = 46/138 (33.33%), Postives = 69/138 (50.00%), Query Frame = 3

Query:  258 RDHDNRNSVFGQLISNLFGGL----------LPLD-FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITEANDTCS----ICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDL 626
            R    R+     +I  + GGL            LD   S P+DY++     D  +T+++ Q + +GPPPA++  I  L    I + +  CS    +C  DY VG+ V +LPC H +H  C+  WL  H +CP+CRK L
Sbjct:  111 RHRVERSPAIEGIIQQMLGGLWGPARSPFPPFTLDVLHSSPADYVWGAGGLDAIITQLLGQLDNTGPPPADKEKISSLPRITIAQEHLNCSMECAVCKEDYSVGESVRQLPCLHLFHSNCIVPWLEMHDSCPVCRKGL 248

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006942.1 (pep scaffold:Pmarinus_7.0:GL476534:934671:936845:1 gene:ENSPMAG00000006277.1 transcript:ENSPMAT00000006942.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 73.1738 bits (178), Expect = 6.997e-17
Identity = 34/89 (38.20%), Postives = 48/89 (53.93%), Query Frame = 3

Query:  333 FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWL 587
              SDP DY +     D  +T+++ Q + SGPPPA+ A I  L    IT+    A   CS+C  D+   + V +LPC+H YH  C+  WL
Sbjct:    3 LHSDPGDYAWGLNGLDRIITQLLEQLDTSGPPPADRARIHTLPNITITQQHVDAGLECSVCREDFAETEVVRQLPCKHMYHNDCIVPWL 91

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: si:ch1073-392o20.1 (ring finger protein 122 [Source:HGNC Symbol;Acc:HGNC:21147])

HSP 1 Score: 53.1434 bits (126), Expect = 5.423e-10
Identity = 19/47 (40.43%), Postives = 29/47 (61.70%), Query Frame = 3

Query:  489 TCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLS 629
            TC++CL D+   DE+   PC+H +H +CL  WL     CP+C K ++
Sbjct:   16 TCAVCLEDFREKDELAVCPCKHAFHRKCLVKWLEIRNACPMCNKPVA 62

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003771.1 (pep scaffold:Pmarinus_7.0:GL488469:4:5386:-1 gene:ENSPMAG00000003449.1 transcript:ENSPMAT00000003771.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 53.1434 bits (126), Expect = 1.305e-9
Identity = 23/60 (38.33%), Postives = 37/60 (61.67%), Query Frame = 3

Query:  486 DTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKH-GTCPICRKDL---SGNDTRLES 653
            D C+ICL +YE G+ +  LPC H +H +C+  WL +    CP+C++ +    G+D+  ES
Sbjct:    5 DVCAICLEEYEEGERLRVLPCAHAFHCKCVDPWLTQQRKNCPVCKRKVVRSHGSDSESES 64

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Yeast
Match: YBR062C_mRNA (Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway [Source:SGD;Acc:S000000266])

HSP 1 Score: 57.7658 bits (138), Expect = 1.125e-10
Identity = 31/83 (37.35%), Postives = 51/83 (61.45%), Query Frame = 3

Query:  399 MNQFEQSGPPPANEADIEKLQVTKITEANDTCSICLSDYEVGDE---VYELP-CQHKYHVQCLKTWLIKHGTCPICRKDLSGN 635
            M++ + +G P    A + ++   K+ +A D CSIC ++Y + DE   V ELP C HK+ ++CL  WL +  TCP+CR ++ G+
Sbjct:   79 MDKGKSAGCPDTFAASLPRINKKKL-KATDNCSICYTNY-LEDEYPLVVELPHCHHKFDLECLSVWLSRSTTCPLCRDNVMGH 159

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO32057 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SW71])

HSP 1 Score: 76.2554 bits (186), Expect = 7.077e-18
Identity = 32/91 (35.16%), Postives = 50/91 (54.95%), Query Frame = 3

Query:  327 LDFRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWL 587
            L    +P DY++     D+ +T+++NQ E +GPPPA    IE L   K+T+    +   C++C    ++ +EV  LPC H YH  C+  WL
Sbjct:    2 LQLHGNPGDYVWGTNGLDSIITQLLNQLEGAGPPPAENDKIENLPKVKVTQSLIDSRTECAVCQEQLKLHEEVLMLPCNHHYHKDCIIPWL 92

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO45479 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RSU5])

HSP 1 Score: 65.4698 bits (158), Expect = 1.178e-13
Identity = 28/81 (34.57%), Postives = 46/81 (56.79%), Query Frame = 3

Query:  426 PPANEADIEKLQVTKITE------ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLE 650
            PPA++  ++ L   K+T+      +  +C ICL DYE G+   ++PC H +H  C+  WL K  +CP+CR +L  ++   E
Sbjct:    1 PPASKEAVQALPAVKVTDKHLKELSTSSCPICLGDYEKGESTKQMPCDHLFHPGCILPWLEKTNSCPVCRHELPTDNEAYE 81

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO29210 (pep supercontig:ASM20922v1:NEMVEscaffold_1403:17060:20569:-1 gene:NEMVEDRAFT_v1g145359 transcript:EDO29210 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 62.3882 bits (150), Expect = 1.182e-12
Identity = 27/80 (33.75%), Postives = 45/80 (56.25%), Query Frame = 3

Query:  429 PANEADIEKLQVTKITE------ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLE 650
            PA++  ++ L   K+T+      +  +C ICL DYE G+   ++PC H +H  C+  WL K  +CP+CR +L  ++   E
Sbjct:    2 PASKEAVQALPAVKVTDKHLKELSTSSCPICLGDYEKGESTKQMPCDHLFHPGCILPWLEKTNSCPVCRHELPTDNEAYE 81

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO41758 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S3E3])

HSP 1 Score: 58.9214 bits (141), Expect = 3.869e-10
Identity = 21/50 (42.00%), Postives = 34/50 (68.00%), Query Frame = 3

Query:  477 EANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDL 626
            E  D+C +CL  Y+ G+ +  LPC H+YH  C+  WL++H TCP+C+ ++
Sbjct:  221 EEIDSCPVCLDGYKSGEVIRILPCNHEYHKLCIDPWLVEHRTCPMCKLNI 270

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO36379 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIX4])

HSP 1 Score: 55.4546 bits (132), Expect = 6.275e-9
Identity = 22/49 (44.90%), Postives = 33/49 (67.35%), Query Frame = 3

Query:  477 EANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIK-HGTCPICRK 620
            E  D C+ICL +Y+ GD++  LPC H YH +C+  WL +   TCP+C++
Sbjct:  261 EYYDVCAICLDEYKEGDKLRILPCDHAYHCKCVDPWLTEGKRTCPVCKR 309

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: rnf126 (E3 ubiquitin-protein ligase RNF126 [Source:NCBI gene;Acc:101164752])

HSP 1 Score: 105.145 bits (261), Expect = 8.914e-26
Identity = 74/269 (27.51%), Postives = 111/269 (41.26%), Query Frame = 3

Query:   54 YFCHKCNRDVHIS-QDGKCVTCNDGFIERI---------------ESDNSMESDDD----------------ALNVFH----IIRHIPS------------------GSTTNETDGSFFITPRDHDNRN---SVFGQLISNLFGGLLPLD------------FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
            +FCH+C+ +V     D  C  CN GFIE +                SD + +S +D                AL +F     +   +PS                    +  +  G +F  PR    R+        +I  L  G++                 S+P DY +     D  +T+++NQFE +GPPPA+   I+ L    IT+    A   C +C  DY + + V +LPC H +H  C+  WL +H TCP+CRK LSG +T
Sbjct:   56 FFCHRCSAEVTPRLPDYTCPRCNSGFIEELPEEISSENRSASTSSASDQNRQSFEDMDHQHFFTFPSGYGPFALGIFDDNFDVRARLPSEDNREAENRREREMASRQRYSARQPRGRYF--PRRQGTRHEGVPTLEGIIQQLVNGIIAPTAMPNIGMGSWGMLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADRERIKSLPTISITQEHISAGLECPVCKEDYSIDERVRQLPCNHLFHNDCIVPWLEQHDTCPVCRKSLSGQNT 322

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: RNF126 (ring finger protein 126 [Source:NCBI gene;Acc:101169433])

HSP 1 Score: 102.834 bits (255), Expect = 3.967e-25
Identity = 44/107 (41.12%), Postives = 65/107 (60.75%), Query Frame = 3

Query:  333 FRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE----ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDT 641
              S+P DY +     D  +T+++NQFE +GPPPA+   I+ L   ++T+    +   C +C  DY VG+ V +LPC H +H  C+  WL +H TCP+CRK LSG +T
Sbjct:  172 LHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADRDKIKSLPTVQVTDEHVASGLECPVCKEDYCVGENVRQLPCNHMFHNDCIVPWLEQHDTCPVCRKSLSGQNT 278

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: rnf115 (ring finger protein 115 [Source:NCBI gene;Acc:101158133])

HSP 1 Score: 94.7449 bits (234), Expect = 2.760e-22
Identity = 46/132 (34.85%), Postives = 67/132 (50.76%), Query Frame = 3

Query:  282 VFGQLISNLFG-----GLLPLDF----RSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITEAND----TCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGND 638
            +  Q ++ LF      G  PL +     S+P DY +     D  +T+++ Q E +GPPPA +  I  L    I++        C +C  D+ VG+ V +LPC H +H  C+  WL  H TCP+CR  LSG D
Sbjct:  160 IVQQFLAGLFANSGVPGSPPLSWTGMLHSNPGDYAWGQGGLDAVITQLLGQLENTGPPPAEKEKISSLPTVNISQEQADCCMECPVCKEDFTVGEPVRKLPCNHFFHSDCIVPWLEMHDTCPVCRMSLSGED 291

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: rlim (ring finger protein, LIM domain interacting [Source:NCBI gene;Acc:101168551])

HSP 1 Score: 68.1662 bits (165), Expect = 1.812e-12
Identity = 23/49 (46.94%), Postives = 38/49 (77.55%), Query Frame = 3

Query:  474 TEANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRK 620
            ++A  TCS+C+++Y  G+++ +LPC H+YHV C+  WL ++ TCPICR+
Sbjct:  591 SDALKTCSVCITEYAEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRR 639

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: rnf181 (ring finger protein 181 [Source:NCBI gene;Acc:101167798])

HSP 1 Score: 62.003 bits (149), Expect = 1.372e-11
Identity = 30/88 (34.09%), Postives = 51/88 (57.95%), Query Frame = 3

Query:  399 MNQFEQSGPPPANEADIEKLQVTKIT-EANDT---CSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLE 650
            ++ ++Q  PPPA +  ++ L V  I+ E  D    C +CL ++E  + V E+PC+H +H  C+  WL K  +CP+CR +L  ++   E
Sbjct:   45 LSDWDQRLPPPAAKTVVQSLTVVIISAEQADKGVKCPVCLLEFEEQETVREMPCKHLFHSGCILPWLGKTNSCPLCRLELPTDNPEYE 132

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000036540.1 (SMESG000036540.1)

HSP 1 Score: 457.988 bits (1177), Expect = 2.007e-165
Identity = 220/220 (100.00%), Postives = 220/220 (100.00%), Query Frame = 3

Query:   30 MATINTDNYFCHKCNRDVHISQDGKCVTCNDGFIERIESDNSMESDDDALNVFHIIRHIPSGSTTNETDGSFFITPRDHDNRNSVFGQLISNLFGGLLPLDFRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITEANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLESHDHIAQSSSNDP 689
            MATINTDNYFCHKCNRDVHISQDGKCVTCNDGFIERIESDNSMESDDDALNVFHIIRHIPSGSTTNETDGSFFITPRDHDNRNSVFGQLISNLFGGLLPLDFRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITEANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLESHDHIAQSSSNDP
Sbjct:    1 MATINTDNYFCHKCNRDVHISQDGKCVTCNDGFIERIESDNSMESDDDALNVFHIIRHIPSGSTTNETDGSFFITPRDHDNRNSVFGQLISNLFGGLLPLDFRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITEANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLSGNDTRLESHDHIAQSSSNDP 220

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000028227.1 (SMESG000028227.1)

HSP 1 Score: 60.4622 bits (145), Expect = 3.395e-10
Identity = 31/121 (25.62%), Postives = 62/121 (51.24%), Query Frame = 3

Query:  270 NRNSVFGQLISNLFGGLLPLDFRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQV--TKITEANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDL 626
            NR SV    IS +   ++ L + +    Y      + +   R+  +   +     N+  ++ L     +++   D C+IC+ +Y+VG+ +  LPC+H +H  C+ +WLI+  +CP+C+ D+
Sbjct:  191 NRTSVLFVSISFILLMIISLVWLTF---YYIQRFRYMHAKERLSRRLANAAKKALNKIPVKILSSDDKEVSYDYDQCAICIDNYQVGETIRILPCKHIFHKICIDSWLIEQRSCPMCKVDI 308

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000013169.1 (SMESG000013169.1)

HSP 1 Score: 59.6918 bits (143), Expect = 4.407e-10
Identity = 25/61 (40.98%), Postives = 38/61 (62.30%), Query Frame = 3

Query:  447 IEKLQVTKITEAND---TCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHG-TCPICR 617
            ++K+ + K  +  D   TC+ICL D++ GD++  LPC H YH  C+  WL+K    CPIC+
Sbjct:  172 LKKIPLKKFVKGRDPFETCAICLDDFKDGDKLRILPCNHAYHANCIDPWLLKQKRNCPICK 232

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000013169.1 (SMESG000013169.1)

HSP 1 Score: 60.077 bits (144), Expect = 4.434e-10
Identity = 25/61 (40.98%), Postives = 38/61 (62.30%), Query Frame = 3

Query:  447 IEKLQVTKITEAND---TCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHG-TCPICR 617
            ++K+ + K  +  D   TC+ICL D++ GD++  LPC H YH  C+  WL+K    CPIC+
Sbjct:  191 LKKIPLKKFVKGRDPFETCAICLDDFKDGDKLRILPCNHAYHANCIDPWLLKQKRNCPICK 251

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000013169.1 (SMESG000013169.1)

HSP 1 Score: 59.6918 bits (143), Expect = 4.927e-10
Identity = 25/61 (40.98%), Postives = 38/61 (62.30%), Query Frame = 3

Query:  447 IEKLQVTKITEAND---TCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHG-TCPICR 617
            ++K+ + K  +  D   TC+ICL D++ GD++  LPC H YH  C+  WL+K    CPIC+
Sbjct:  206 LKKIPLKKFVKGRDPFETCAICLDDFKDGDKLRILPCNHAYHANCIDPWLLKQKRNCPICK 266

The following BLAST results are available for this feature:

BLAST of RING-type domain-containing protein vs. Ensembl Human
BLAST of RING-type domain-containing protein vs. Ensembl Celegans
BLAST of RING-type domain-containing protein vs. Ensembl Fly
BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
BLAST of RING-type domain-containing protein vs. Ensembl Mouse
BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
BLAST of RING-type domain-containing protein vs. TrEMBL
BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
BLAST of RING-type domain-containing protein vs. Ensembl Yeast
BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
BLAST of RING-type domain-containing protein vs. Ensembl Medaka
BLAST of RING-type domain-containing protein vs. Planmine SMEST

BLAST of RING-type domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
RNF126	3.407e-30	27.82	ring finger protein 126 [Source:HGNC Symbol;Acc:HG...	[more]
RNF126	6.880e-25	25.09	ring finger protein 126 [Source:HGNC Symbol;Acc:HG...	[more]
RNF115	1.961e-23	38.40	ring finger protein 115 [Source:HGNC Symbol;Acc:HG...	[more]
RLIM	9.036e-13	36.90	ring finger protein, LIM domain interacting [Sourc...	[more]
RLIM	9.036e-13	36.90	ring finger protein, LIM domain interacting [Sourc...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
H10E21.5	1.645e-10	42.00	pep chromosome:WBcel235:III:20531:23962:-1 gene:WB...	[more]
C01G6.4	5.523e-9	43.18	pep chromosome:WBcel235:II:9271265:9273042:-1 gene...	[more]
C18B12.4	8.060e-9	30.68	pep chromosome:WBcel235:X:15036662:15040602:-1 gen...	[more]
toe-4	1.344e-8	40.00	Target Of ERK kinase MPK-1 [Source:UniProtKB/TrEM...	[more]
plr-1	8.101e-8	40.82	Probable E3 ubiquitin-protein ligase plr-1 [Sourc...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Iru	2.431e-22	42.20	gene:FBgn0037653 transcript:FBtr0081965	[more]
CG7694	1.028e-10	31.73	gene:FBgn0038627 transcript:FBtr0290211	[more]
CG7694	1.028e-10	31.73	gene:FBgn0038627 transcript:FBtr0083632	[more]
CG7694	1.028e-10	31.73	gene:FBgn0038627 transcript:FBtr0344291	[more]
gol	8.225e-10	43.75	gene:FBgn0004919 transcript:FBtr0300179	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rnf126	3.312e-25	41.12	ring finger protein 126 [Source:ZFIN;Acc:ZDB-GENE-...	[more]
rnf115	2.524e-24	35.77	ring finger protein 115 [Source:ZFIN;Acc:ZDB-GENE-...	[more]
si:ch211-81a5.1	1.167e-21	38.68	si:ch211-81a5.1 [Source:ZFIN;Acc:ZDB-GENE-060503-6...	[more]
si:ch211-81a5.1	1.423e-21	38.68	si:ch211-81a5.1 [Source:ZFIN;Acc:ZDB-GENE-060503-6...	[more]
si:ch211-59o9.10	4.649e-13	33.67	si:ch211-59o9.10 [Source:ZFIN;Acc:ZDB-GENE-101206-...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rnf126	4.780e-27	42.02	ring finger protein 126 [Source:NCBI gene;Acc:4484...	[more]
rnf126	2.353e-26	42.50	ring finger protein 126 [Source:NCBI gene;Acc:4484...	[more]
stxbp3	1.632e-23	31.41	syntaxin binding protein 3 [Source:Xenbase;Acc:XB-...	[more]
stxbp3	3.007e-23	31.41	syntaxin binding protein 3 [Source:Xenbase;Acc:XB-...	[more]
stxbp3	5.005e-23	31.41	syntaxin binding protein 3 [Source:Xenbase;Acc:XB-...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Rnf126	2.087e-25	39.47	ring finger protein 126 [Source:MGI Symbol;Acc:MGI...	[more]
Rnf115	2.371e-23	25.27	ring finger protein 115 [Source:MGI Symbol;Acc:MGI...	[more]
Rnf181	2.056e-15	38.82	ring finger protein 181 [Source:MGI Symbol;Acc:MGI...	[more]
Rnf181	2.056e-15	38.82	ring finger protein 181 [Source:MGI Symbol;Acc:MGI...	[more]
Rnf181	4.963e-15	38.82	ring finger protein 181 [Source:MGI Symbol;Acc:MGI...	[more]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q6DIP3\|RN126_XENTR	9.096e-26	42.50	E3 ubiquitin-protein ligase RNF126 OS=Xenopus trop...	[more]
sp\|Q6IRP0\|R126B_XENLA	2.696e-25	42.50	E3 ubiquitin-protein ligase RNF126-B OS=Xenopus la...	[more]
sp\|Q7T0Q3\|R126A_XENLA	3.113e-25	42.50	E3 ubiquitin-protein ligase RNF126-A OS=Xenopus la...	[more]
sp\|Q91YL2\|RN126_MOUSE	1.459e-24	39.47	E3 ubiquitin-protein ligase RNF126 OS=Mus musculus...	[more]
sp\|Q0II22\|RN126_BOVIN	2.511e-24	40.00	E3 ubiquitin-protein ligase RNF126 OS=Bos taurus O...	[more]

BLAST of RING-type domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
G4LWM6	7.199e-30	32.03	Zinc finger protein, putative OS=Schistosoma manso...	[more]
A0A2C9L8K4	3.262e-29	33.33	RING-type domain-containing protein OS=Biomphalari...	[more]
T1KM53	8.851e-29	33.66	RING-type domain-containing protein OS=Tetranychus...	[more]
G4LWM7	1.218e-28	32.42	Zinc finger protein, putative OS=Schistosoma manso...	[more]
A0A3R7FL85	2.032e-28	48.18	E3 ubiquitin-protein ligase OS=Clonorchis sinensis...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rnf126	8.182e-27	42.99	ring finger protein 126 [Source:ZFIN;Acc:ZDB-GENE-...	[more]
rnf126	1.441e-26	42.11	ring finger protein 126 [Source:ZFIN;Acc:ZDB-GENE-...	[more]
rnf126	1.750e-26	43.81	ring finger protein 126 [Source:ZFIN;Acc:ZDB-GENE-...	[more]
rnf115	2.818e-24	36.09	ring finger protein 115 [Source:NCBI gene;Acc:1071...	[more]
si:ch211-81a5.1	7.535e-23	35.25	si:ch211-81a5.1 [Source:ZFIN;Acc:ZDB-GENE-060503-6...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rnf126	2.903e-27	33.76	ring finger protein 126 [Source:ZFIN;Acc:ZDB-GENE-...	[more]
RNF115	1.519e-22	33.33	ring finger protein 115 [Source:HGNC Symbol;Acc:HG...	[more]
ENSPMAT00000006942.1	6.997e-17	38.20	pep scaffold:Pmarinus_7.0:GL476534:934671:936845:1...	[more]
si:ch1073-392o20.1	5.423e-10	40.43	ring finger protein 122 [Source:HGNC Symbol;Acc:HG...	[more]
ENSPMAT00000003771.1	1.305e-9	38.33	pep scaffold:Pmarinus_7.0:GL488469:4:5386:-1 gene:...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
YBR062C_mRNA	1.125e-10	37.35	Protein of unknown function that interacts with Ms...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO32057	7.077e-18	35.16	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO45479	1.178e-13	34.57	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO29210	1.182e-12	33.75	pep supercontig:ASM20922v1:NEMVEscaffold_1403:1706...	[more]
EDO41758	3.869e-10	42.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36379	6.275e-9	44.90	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rnf126	8.914e-26	27.51	E3 ubiquitin-protein ligase RNF126 [Source:NCBI ge...	[more]
RNF126	3.967e-25	41.12	ring finger protein 126 [Source:NCBI gene;Acc:1011...	[more]
rnf115	2.760e-22	34.85	ring finger protein 115 [Source:NCBI gene;Acc:1011...	[more]
rlim	1.812e-12	46.94	ring finger protein, LIM domain interacting [Sourc...	[more]
rnf181	1.372e-11	34.09	ring finger protein 181 [Source:NCBI gene;Acc:1011...	[more]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000036540.1	2.007e-165	100.00	SMESG000036540.1	[more]
SMESG000028227.1	3.395e-10	25.62	SMESG000028227.1	[more]
SMESG000013169.1	4.407e-10	40.98	SMESG000013169.1	[more]
SMESG000013169.1	4.434e-10	40.98	SMESG000013169.1	[more]
SMESG000013169.1	4.927e-10	40.98	SMESG000013169.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30024395 ID=SMED30024395|Name=RING-type domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=853bp
CTTAAATTAATTATTTTTAAATTTGTTTAATGGCTACGATTAATACAGAT
AATTACTTTTGTCATAAATGCAACAGGGACGTTCACATATCTCAGGATGG
TAAATGTGTAACGTGCAATGATGGATTTATTGAAAGAATTGAATCTGATA
ACTCAATGGAAAGTGATGATGATGCCTTGAATGTTTTTCACATTATTCGT
CATATACCAAGTGGGAGCACTACAAATGAAACTGATGGTTCTTTTTTTAT
TACTCCAAGAGATCATGATAACAGAAATAGTGTATTTGGCCAATTAATAT
CAAATTTATTTGGTGGATTGTTACCTCTAGATTTTAGATCAGATCCGTCA
GATTATATATTTTCAGATCAAAGTTTCGACAATTTTGTAACGAGAATTAT
GAATCAATTTGAACAGAGCGGTCCTCCACCAGCAAATGAGGCAGACATTG
AGAAGCTACAAGTCACTAAGATCACCGAAGCTAATGATACATGTTCCATT
TGTCTGTCAGATTATGAAGTGGGCGATGAAGTCTACGAGTTACCCTGTCA
GCATAAATATCACGTTCAGTGTCTAAAAACGTGGTTGATAAAACACGGAA
CTTGTCCGATTTGTCGAAAAGATTTATCAGGAAACGATACGCGATTAGAG
AGCCATGATCATATTGCACAAAGTTCATCGAATGATCCTTAGATTTGGTT
TCTTGCTCTTCGAGATATAATTGTTTATATCAGTCTATTTGTATGCTGAA
GTCAATGATAAAGAATAAAATTTATGACATCAATTTGTTGTTTACTTTAC
ATTTAAAATTATAGGTCACCCTTTTTTGTTTTAGAAATAATGTATTTTTA
TAC

protein sequence of SMED30024395-orf-1

>SMED30024395-orf-1 ID=SMED30024395-orf-1|Name=SMED30024395-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=221bp
MATINTDNYFCHKCNRDVHISQDGKCVTCNDGFIERIESDNSMESDDDAL
NVFHIIRHIPSGSTTNETDGSFFITPRDHDNRNSVFGQLISNLFGGLLPL
DFRSDPSDYIFSDQSFDNFVTRIMNQFEQSGPPPANEADIEKLQVTKITE
ANDTCSICLSDYEVGDEVYELPCQHKYHVQCLKTWLIKHGTCPICRKDLS
GNDTRLESHDHIAQSSSNDP*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **biological process**
Term	Definition
GO:0016567	protein ubiquitination

Vocabulary: **molecular function**
Term	Definition
GO:0061630	ubiquitin protein ligase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0000429	neoblast

Vocabulary: **INTERPRO**
Term	Definition
IPR039525	RNF126-like_zinc-ribbon
IPR001841	Znf_RING
IPR013083	Znf_RING/FYVE/PHD

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001841	Zinc finger, RING-type	SMART	SM00184	ring_2	coord: 155..195 e-value: 2.0E-6 score: 37.4
IPR001841	Zinc finger, RING-type	PFAM	PF13639	zf-RING_2	coord: 153..196 e-value: 2.3E-14 score: 53.4
IPR001841	Zinc finger, RING-type	PROSITE	PS50089	ZF_RING_2	coord: 155..196 score: 12.106
IPR039525	E3 ubiquitin-protein ligase RNF126-like, zinc-ribbon	PFAM	PF14369	zinc_ribbon_9	coord: 9..37 e-value: 1.5E-7 score: 31.5
IPR013083	Zinc finger, RING/FYVE/PHD-type	GENE3D	G3DSA:3.30.40.10		coord: 121..201 e-value: 1.2E-21 score: 78.1
None	No IPR available	PANTHER	PTHR15710	E3 UBIQUITIN-PROTEIN LIGASE PRAJA	coord: 100..211
None	No IPR available	PANTHER	PTHR15710:SF48		coord: 100..211
None	No IPR available	CDD	cd16454	RING-H2_PA-TM-RING	coord: 154..196 e-value: 2.52295E-18 score: 73.1049
None	No IPR available	SUPERFAMILY	SSF57850	RING/U-box	coord: 146..200