Tousled-like kinase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30024332 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of Tousled-like kinase vs. Ensembl Human
Match: TLK2 (tousled like kinase 2 [Source:HGNC Symbol;Acc:HGNC:11842]) HSP 1 Score: 418.698 bits (1075), Expect = 7.756e-139 Identity = 227/452 (50.22%), Postives = 306/452 (67.70%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG------------DRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIF-PDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ I Q+E+ E++RK L K KP R N L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + + PIIH+DLKP NIL+V+ G+IK+TDFGLSKI DS + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRKPFGH+Q+Q DIL NTI A V F P P V+ AK FI +CL Y ++DR + QL YL P +
Sbjct: 123 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 574
BLAST of Tousled-like kinase vs. Ensembl Human
Match: TLK2 (tousled like kinase 2 [Source:HGNC Symbol;Acc:HGNC:11842]) HSP 1 Score: 419.468 bits (1077), Expect = 1.245e-137 Identity = 227/452 (50.22%), Postives = 306/452 (67.70%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG------------DRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIF-PDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ I Q+E+ E++RK L K KP R N L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + + PIIH+DLKP NIL+V+ G+IK+TDFGLSKI DS + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRKPFGH+Q+Q DIL NTI A V F P P V+ AK FI +CL Y ++DR + QL YL P +
Sbjct: 240 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 691
BLAST of Tousled-like kinase vs. Ensembl Human
Match: TLK2 (tousled like kinase 2 [Source:HGNC Symbol;Acc:HGNC:11842]) HSP 1 Score: 418.698 bits (1075), Expect = 6.810e-137 Identity = 227/452 (50.22%), Postives = 306/452 (67.70%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG------------DRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIF-PDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ I Q+E+ E++RK L K KP R N L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + + PIIH+DLKP NIL+V+ G+IK+TDFGLSKI DS + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRKPFGH+Q+Q DIL NTI A V F P P V+ AK FI +CL Y ++DR + QL YL P +
Sbjct: 272 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 723
BLAST of Tousled-like kinase vs. Ensembl Human
Match: TLK1 (tousled like kinase 1 [Source:HGNC Symbol;Acc:HGNC:11841]) HSP 1 Score: 411.379 bits (1056), Expect = 4.996e-135 Identity = 224/463 (48.38%), Postives = 308/463 (66.52%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKP-VGDRGKLGKPRANP-----------ELDPY------------EFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S +E+ ++ K +RL+LG + TVRHG + +++ G F + +++ + +Q+ED E++RK L K KP + + + P E DP+ E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLNERY++L LLG+GGFSEVYKAFDL +QR+ A K H+LN++W +EKK++Y +H RE +I K L+HPRIV ++D F++D+DTF VLEYC+GNDLDFYLKQ+K + E++ + ++ Q+V+A++YL + + PIIH+DLKP NIL+VD G+IK+TDFGLSKI D DG++LTSQGAGTYWYLPPECFV P I +KVDVWS+GV F+QCLYGRKPFGH+Q+Q DIL NTI A V F P VS AK FI +CL Y ++DR + QL YL P +
Sbjct: 180 KLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHM 642
BLAST of Tousled-like kinase vs. Ensembl Human
Match: TLK1 (tousled like kinase 1 [Source:HGNC Symbol;Acc:HGNC:11841]) HSP 1 Score: 412.149 bits (1058), Expect = 8.309e-135 Identity = 224/463 (48.38%), Postives = 308/463 (66.52%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKP-VGDRGKLGKPRANP-----------ELDPY------------EFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S +E+ ++ K +RL+LG + TVRHG + +++ G F + +++ + +Q+ED E++RK L K KP + + + P E DP+ E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLNERY++L LLG+GGFSEVYKAFDL +QR+ A K H+LN++W +EKK++Y +H RE +I K L+HPRIV ++D F++D+DTF VLEYC+GNDLDFYLKQ+K + E++ + ++ Q+V+A++YL + + PIIH+DLKP NIL+VD G+IK+TDFGLSKI D DG++LTSQGAGTYWYLPPECFV P I +KVDVWS+GV F+QCLYGRKPFGH+Q+Q DIL NTI A V F P VS AK FI +CL Y ++DR + QL YL P +
Sbjct: 228 KLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHM 690
BLAST of Tousled-like kinase vs. Ensembl Celegans
Match: tlk-1 (Serine/threonine-protein kinase tousled-like 1 [Source:UniProtKB/Swiss-Prot;Acc:P34314]) HSP 1 Score: 382.489 bits (981), Expect = 6.494e-122 Identity = 214/496 (43.15%), Postives = 299/496 (60.28%), Query Frame = 1
Query: 454 RLMIQRLEKENRELSDHQKIEKENLIKSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGKPRA--------------------------NPELDPYEFFIQS--EKIEINKVRXXXXXXXXXXXXXXXTR---AKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILI----VDGDIKVTDFGLSKIFP-DSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPK 1833
R I+ L +N + KE + + LI+ +Q ER + K + ++G + T R G + ++V G F E++ K + I ++ + L K KP+G + +P+A PE +P E Q E EI K+R KE + R K H+RE+KR NE AS+FND L++RY++L+LLGKGGFSEV+KAFD+++ R+VACK H +N++W EKK +Y++H +RE I KSL+H RIV +D+ +D+ +F VLEY GNDLDFYLKQN+ + E++ + +I Q+VSA+ YL ++ TPIIH+DLKP+NIL+ G IK+TDFGLSKI +SD GIELTSQ AGTYWYLPPE F+ P I KVDVWSIGV FYQC+YG+KPFG+D TQ IL NTI A+ V+F P+VS AA++FI +CL Y ++DR +F+L H+ RP+
Sbjct: 358 RRQIEELNSKNSLERRKNEASKETIKRLLIDKNQIERKALRDKTAADSPRIGCFKTTRTGDSFRDQWVDGWAFAEMDKKTEQINAERNEIASASALLKKRKPLGIGKEPKRPQAVNSQNDSNGMQPSTSSNTNGDDAIFRRPE-EPKEIQYQEYIELDEIYKLRREHLRKEETDLSMEKERLEKEKQHHVRELKRASNESASQFNDHRLLHKRYLMLNLLGKGGFSEVWKAFDIEENRYVACKIHHVNKDWKEEKKANYVKHAMREKDIHKSLDHCRIVKQYDLLTIDNHSFCTVLEYVPGNDLDFYLKQNRSISEKEARSIIMQVVSALVYLNEKSTPIIHYDLKPANILLESGNTSGAIKITDFGLSKIMEGESDDHDLGIELTSQFAGTYWYLPPETFIVP--PPKITCKVDVWSIGVIFYQCIYGKKPFGNDLTQQKILEYNTIINAREVSFPSKPQVSSAAQDFIRRCLQYRKEDRADVFELAKHELFRPR 850
BLAST of Tousled-like kinase vs. Ensembl Celegans
Match: tlk-1 (Serine/threonine-protein kinase tousled-like 1 [Source:UniProtKB/Swiss-Prot;Acc:P34314]) HSP 1 Score: 381.719 bits (979), Expect = 1.477e-121 Identity = 214/496 (43.15%), Postives = 299/496 (60.28%), Query Frame = 1
Query: 454 RLMIQRLEKENRELSDHQKIEKENLIKSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGKPRA--------------------------NPELDPYEFFIQS--EKIEINKVRXXXXXXXXXXXXXXXTR---AKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILI----VDGDIKVTDFGLSKIFP-DSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPK 1833
R I+ L +N + KE + + LI+ +Q ER + K + ++G + T R G + ++V G F E++ K + I ++ + L K KP+G + +P+A PE +P E Q E EI K+R KE + R K H+RE+KR NE AS+FND L++RY++L+LLGKGGFSEV+KAFD+++ R+VACK H +N++W EKK +Y++H +RE I KSL+H RIV +D+ +D+ +F VLEY GNDLDFYLKQN+ + E++ + +I Q+VSA+ YL ++ TPIIH+DLKP+NIL+ G IK+TDFGLSKI +SD GIELTSQ AGTYWYLPPE F+ P I KVDVWSIGV FYQC+YG+KPFG+D TQ IL NTI A+ V+F P+VS AA++FI +CL Y ++DR +F+L H+ RP+
Sbjct: 372 RRQIEELNSKNSLERRKNEASKETIKRLLIDKNQIERKALRDKTAADSPRIGCFKTTRTGDSFRDQWVDGWAFAEMDKKTEQINAERNEIASASALLKKRKPLGIGKEPKRPQAVNSQNDSNGMQPSTSSNTNGDDAIFRRPE-EPKEIQYQEYIELDEIYKLRREHLRKEETDLSMEKERLEKEKQHHVRELKRASNESASQFNDHRLLHKRYLMLNLLGKGGFSEVWKAFDIEENRYVACKIHHVNKDWKEEKKANYVKHAMREKDIHKSLDHCRIVKQYDLLTIDNHSFCTVLEYVPGNDLDFYLKQNRSISEKEARSIIMQVVSALVYLNEKSTPIIHYDLKPANILLESGNTSGAIKITDFGLSKIMEGESDDHDLGIELTSQFAGTYWYLPPETFIVP--PPKITCKVDVWSIGVIFYQCIYGKKPFGNDLTQQKILEYNTIINAREVSFPSKPQVSSAAQDFIRRCLQYRKEDRADVFELAKHELFRPR 864
BLAST of Tousled-like kinase vs. Ensembl Celegans
Match: tlk-1 (Serine/threonine-protein kinase tousled-like 1 [Source:UniProtKB/Swiss-Prot;Acc:P34314]) HSP 1 Score: 382.489 bits (981), Expect = 3.470e-121 Identity = 214/496 (43.15%), Postives = 299/496 (60.28%), Query Frame = 1
Query: 454 RLMIQRLEKENRELSDHQKIEKENLIKSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGKPRA--------------------------NPELDPYEFFIQS--EKIEINKVRXXXXXXXXXXXXXXXTR---AKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILI----VDGDIKVTDFGLSKIFP-DSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPK 1833
R I+ L +N + KE + + LI+ +Q ER + K + ++G + T R G + ++V G F E++ K + I ++ + L K KP+G + +P+A PE +P E Q E EI K+R KE + R K H+RE+KR NE AS+FND L++RY++L+LLGKGGFSEV+KAFD+++ R+VACK H +N++W EKK +Y++H +RE I KSL+H RIV +D+ +D+ +F VLEY GNDLDFYLKQN+ + E++ + +I Q+VSA+ YL ++ TPIIH+DLKP+NIL+ G IK+TDFGLSKI +SD GIELTSQ AGTYWYLPPE F+ P I KVDVWSIGV FYQC+YG+KPFG+D TQ IL NTI A+ V+F P+VS AA++FI +CL Y ++DR +F+L H+ RP+
Sbjct: 439 RRQIEELNSKNSLERRKNEASKETIKRLLIDKNQIERKALRDKTAADSPRIGCFKTTRTGDSFRDQWVDGWAFAEMDKKTEQINAERNEIASASALLKKRKPLGIGKEPKRPQAVNSQNDSNGMQPSTSSNTNGDDAIFRRPE-EPKEIQYQEYIELDEIYKLRREHLRKEETDLSMEKERLEKEKQHHVRELKRASNESASQFNDHRLLHKRYLMLNLLGKGGFSEVWKAFDIEENRYVACKIHHVNKDWKEEKKANYVKHAMREKDIHKSLDHCRIVKQYDLLTIDNHSFCTVLEYVPGNDLDFYLKQNRSISEKEARSIIMQVVSALVYLNEKSTPIIHYDLKPANILLESGNTSGAIKITDFGLSKIMEGESDDHDLGIELTSQFAGTYWYLPPETFIVP--PPKITCKVDVWSIGVIFYQCIYGKKPFGNDLTQQKILEYNTIINAREVSFPSKPQVSSAAQDFIRRCLQYRKEDRADVFELAKHELFRPR 931
BLAST of Tousled-like kinase vs. Ensembl Celegans
Match: tlk-1 (Serine/threonine-protein kinase tousled-like 1 [Source:UniProtKB/Swiss-Prot;Acc:P34314]) HSP 1 Score: 382.489 bits (981), Expect = 3.550e-121 Identity = 214/496 (43.15%), Postives = 299/496 (60.28%), Query Frame = 1
Query: 454 RLMIQRLEKENRELSDHQKIEKENLIKSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGKPRA--------------------------NPELDPYEFFIQS--EKIEINKVRXXXXXXXXXXXXXXXTR---AKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILI----VDGDIKVTDFGLSKIFP-DSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPK 1833
R I+ L +N + KE + + LI+ +Q ER + K + ++G + T R G + ++V G F E++ K + I ++ + L K KP+G + +P+A PE +P E Q E EI K+R KE + R K H+RE+KR NE AS+FND L++RY++L+LLGKGGFSEV+KAFD+++ R+VACK H +N++W EKK +Y++H +RE I KSL+H RIV +D+ +D+ +F VLEY GNDLDFYLKQN+ + E++ + +I Q+VSA+ YL ++ TPIIH+DLKP+NIL+ G IK+TDFGLSKI +SD GIELTSQ AGTYWYLPPE F+ P I KVDVWSIGV FYQC+YG+KPFG+D TQ IL NTI A+ V+F P+VS AA++FI +CL Y ++DR +F+L H+ RP+
Sbjct: 439 RRQIEELNSKNSLERRKNEASKETIKRLLIDKNQIERKALRDKTAADSPRIGCFKTTRTGDSFRDQWVDGWAFAEMDKKTEQINAERNEIASASALLKKRKPLGIGKEPKRPQAVNSQNDSNGMQPSTSSNTNGDDAIFRRPE-EPKEIQYQEYIELDEIYKLRREHLRKEETDLSMEKERLEKEKQHHVRELKRASNESASQFNDHRLLHKRYLMLNLLGKGGFSEVWKAFDIEENRYVACKIHHVNKDWKEEKKANYVKHAMREKDIHKSLDHCRIVKQYDLLTIDNHSFCTVLEYVPGNDLDFYLKQNRSISEKEARSIIMQVVSALVYLNEKSTPIIHYDLKPANILLESGNTSGAIKITDFGLSKIMEGESDDHDLGIELTSQFAGTYWYLPPETFIVP--PPKITCKVDVWSIGVIFYQCIYGKKPFGNDLTQQKILEYNTIINAREVSFPSKPQVSSAAQDFIRRCLQYRKEDRADVFELAKHELFRPR 931
BLAST of Tousled-like kinase vs. Ensembl Celegans
Match: unc-82 (pep chromosome:WBcel235:IV:7425729:7444660:1 gene:WBGene00006814.1 transcript:B0496.3h.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:unc-82) HSP 1 Score: 122.865 bits (307), Expect = 1.163e-28 Identity = 94/285 (32.98%), Postives = 140/285 (49.12%), Query Frame = 1
Query: 982 PTLNE--RYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILI-VDGDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPF-GHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYL 1824
PT E R+ + LG G + +V A+D + R VA K L + E K +R REI+I +LNHP I+ +++VF + D ++V+EY G +L Y+ + LPE + + + Q+ SAV Y R + H DLK NIL+ + + K+ DFGLS F D + L + G+ Y PE + +G P +VD WS+G+ Y +YG PF G D N +R K A+ P+ A I L N + R TIF + +H +L
Sbjct: 50 PTKKEKHRFEITKKLGSGTYGKVSLAYDHKFDREVAVK---LIKKSAIESKADLVRI-RREIRIMSALNHPNIIQIYEVFE-NKDKIILVMEYSSGGELYDYVSRCGSLPEAEARRIFRQITSAVLYCHKHR--VAHRDLKLENILLDQNNNAKIADFGLSNYFADKN-------LLTTFCGSPLYASPE--IINGTP-YKGPEVDCWSLGILLYTLVYGSMPFDGRD-------FNRMVRQIKRGAYF-EPETPSTASMLIRNMLRVNPERRATIFDIASHWWL 309
BLAST of Tousled-like kinase vs. Ensembl Fly
Match: Tlk (gene:FBgn0283657 transcript:FBtr0299579) HSP 1 Score: 390.963 bits (1003), Expect = 6.071e-122 Identity = 182/314 (57.96%), Postives = 242/314 (77.07%), Query Frame = 1
Query: 910 RAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTAD-GIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
R +N H+RE+KR+ NE+ SRFN+ P LN+RY++L LLGKGGFSEV+KAFDL++QR+VACK H+LN++W +KK +YI+H LRE I K+L+HPR+V ++DVF +D+++F VLEYCDG+DLDFYLKQ+K +PER+ + +I Q+VSA+KYL + + P+IH+DLKP NIL+ + G+IK+TDFGLSK+ D + D G++LTSQGAGTYWYLPPECFV P I SKVDVWS+GV FYQCLYG+KPFGH+Q+Q IL NTI A V F P VS+ AK FI CL Y ++DR +F L H+Y++P +
Sbjct: 886 RERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPI 1199
BLAST of Tousled-like kinase vs. Ensembl Fly
Match: Tlk (gene:FBgn0283657 transcript:FBtr0333753) HSP 1 Score: 390.578 bits (1002), Expect = 6.480e-122 Identity = 182/314 (57.96%), Postives = 242/314 (77.07%), Query Frame = 1
Query: 910 RAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTAD-GIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
R +N H+RE+KR+ NE+ SRFN+ P LN+RY++L LLGKGGFSEV+KAFDL++QR+VACK H+LN++W +KK +YI+H LRE I K+L+HPR+V ++DVF +D+++F VLEYCDG+DLDFYLKQ+K +PER+ + +I Q+VSA+KYL + + P+IH+DLKP NIL+ + G+IK+TDFGLSK+ D + D G++LTSQGAGTYWYLPPECFV P I SKVDVWS+GV FYQCLYG+KPFGH+Q+Q IL NTI A V F P VS+ AK FI CL Y ++DR +F L H+Y++P +
Sbjct: 873 RERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPI 1186
BLAST of Tousled-like kinase vs. Ensembl Fly
Match: Tlk (gene:FBgn0283657 transcript:FBtr0345319) HSP 1 Score: 390.578 bits (1002), Expect = 6.480e-122 Identity = 182/314 (57.96%), Postives = 242/314 (77.07%), Query Frame = 1
Query: 910 RAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTAD-GIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
R +N H+RE+KR+ NE+ SRFN+ P LN+RY++L LLGKGGFSEV+KAFDL++QR+VACK H+LN++W +KK +YI+H LRE I K+L+HPR+V ++DVF +D+++F VLEYCDG+DLDFYLKQ+K +PER+ + +I Q+VSA+KYL + + P+IH+DLKP NIL+ + G+IK+TDFGLSK+ D + D G++LTSQGAGTYWYLPPECFV P I SKVDVWS+GV FYQCLYG+KPFGH+Q+Q IL NTI A V F P VS+ AK FI CL Y ++DR +F L H+Y++P +
Sbjct: 873 RERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPI 1186
BLAST of Tousled-like kinase vs. Ensembl Fly
Match: Tlk (gene:FBgn0283657 transcript:FBtr0299583) HSP 1 Score: 390.578 bits (1002), Expect = 6.480e-122 Identity = 182/314 (57.96%), Postives = 242/314 (77.07%), Query Frame = 1
Query: 910 RAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTAD-GIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
R +N H+RE+KR+ NE+ SRFN+ P LN+RY++L LLGKGGFSEV+KAFDL++QR+VACK H+LN++W +KK +YI+H LRE I K+L+HPR+V ++DVF +D+++F VLEYCDG+DLDFYLKQ+K +PER+ + +I Q+VSA+KYL + + P+IH+DLKP NIL+ + G+IK+TDFGLSK+ D + D G++LTSQGAGTYWYLPPECFV P I SKVDVWS+GV FYQCLYG+KPFGH+Q+Q IL NTI A V F P VS+ AK FI CL Y ++DR +F L H+Y++P +
Sbjct: 873 RERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPI 1186
BLAST of Tousled-like kinase vs. Ensembl Fly
Match: Tlk (gene:FBgn0283657 transcript:FBtr0070596) HSP 1 Score: 390.963 bits (1003), Expect = 6.838e-122 Identity = 182/314 (57.96%), Postives = 242/314 (77.07%), Query Frame = 1
Query: 910 RAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTAD-GIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
R +N H+RE+KR+ NE+ SRFN+ P LN+RY++L LLGKGGFSEV+KAFDL++QR+VACK H+LN++W +KK +YI+H LRE I K+L+HPR+V ++DVF +D+++F VLEYCDG+DLDFYLKQ+K +PER+ + +I Q+VSA+KYL + + P+IH+DLKP NIL+ + G+IK+TDFGLSK+ D + D G++LTSQGAGTYWYLPPECFV P I SKVDVWS+GV FYQCLYG+KPFGH+Q+Q IL NTI A V F P VS+ AK FI CL Y ++DR +F L H+Y++P +
Sbjct: 885 RERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPI 1198
BLAST of Tousled-like kinase vs. Ensembl Zebrafish
Match: tlk2 (tousled-like kinase 2 [Source:NCBI gene;Acc:407732]) HSP 1 Score: 421.779 bits (1083), Expect = 5.183e-139 Identity = 226/451 (50.11%), Postives = 306/451 (67.85%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG------------DRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ + Q+E+ E++RK L K KP R N L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + R PIIH+DLKP NIL+V+ G+IK+TDFGLSKI D + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYG+KPFGH+Q+Q DIL NTI A V F P P VS AK FI +CL Y ++DR + QL + YL P +
Sbjct: 220 KLLIEKSKQEKIACREKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLVKQQERVNGQREEIERQRKLLMKKKPPSASQTPPPNLEPNKRKSKSNGAENEMLSLAEYHEQEEIFKLRLGHLKKEEAEIQVELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQVVNALKYLNEIRPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDNYGVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGKKPFGHNQSQQDILQENTILKATEVQFPPKPGVSPEAKAFIRRCLVYRKEDRIDVHQLASDPYLLPHI 670
BLAST of Tousled-like kinase vs. Ensembl Zebrafish
Match: tlk2 (tousled-like kinase 2 [Source:NCBI gene;Acc:407732]) HSP 1 Score: 421.394 bits (1082), Expect = 7.968e-139 Identity = 226/451 (50.11%), Postives = 306/451 (67.85%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG------------DRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ + Q+E+ E++RK L K KP R N L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + R PIIH+DLKP NIL+V+ G+IK+TDFGLSKI D + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYG+KPFGH+Q+Q DIL NTI A V F P P VS AK FI +CL Y ++DR + QL + YL P +
Sbjct: 220 KLLIEKSKQEKIACREKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLVKQQERVNGQREEIERQRKLLIKKKPPSASQTPPPNLEPNKRKSKSNGAENEMLSLAEYHEQEEIFKLRLGHLKKEEAEIQVELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQVVNALKYLNEIRPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDNYGVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGKKPFGHNQSQQDILQENTILKATEVQFPPKPGVSPEAKAFIRRCLVYRKEDRIDVHQLASDPYLLPHI 670
BLAST of Tousled-like kinase vs. Ensembl Zebrafish
Match: tlk2 (tousled-like kinase 2 [Source:NCBI gene;Acc:407732]) HSP 1 Score: 421.394 bits (1082), Expect = 7.968e-139 Identity = 226/451 (50.11%), Postives = 306/451 (67.85%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG------------DRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ + Q+E+ E++RK L K KP R N L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + R PIIH+DLKP NIL+V+ G+IK+TDFGLSKI D + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYG+KPFGH+Q+Q DIL NTI A V F P P VS AK FI +CL Y ++DR + QL + YL P +
Sbjct: 220 KLLIEKSKQEKIACREKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLVKQQERVNGQREEIERQRKLLIKKKPPSASQTPPPNLEPNKRKSKSNGAENEMLSLAEYHEQEEIFKLRLGHLKKEEAEIQVELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQVVNALKYLNEIRPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDNYGVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGKKPFGHNQSQQDILQENTILKATEVQFPPKPGVSPEAKAFIRRCLVYRKEDRIDVHQLASDPYLLPHI 670
BLAST of Tousled-like kinase vs. Ensembl Zebrafish
Match: tlk1a (tousled-like kinase 1a [Source:ZFIN;Acc:ZDB-GENE-071008-2]) HSP 1 Score: 411.764 bits (1057), Expect = 1.236e-134 Identity = 224/463 (48.38%), Postives = 308/463 (66.52%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGD------------RGKLGKPRANPELDPY------------EFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S +E+ + K +RL+LG + TVRHG + +++ G F + +++ I +Q+E+ E++RK L K KP + + K E DP+ E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE++S+F D PTLNERY++L LLG+GGFSEVYKAFDL +QR+ A K H+LN+NW EKK++Y +H RE +I K L+HPRIV ++D F++D+DTF VLEYC+GNDLDFYLKQ+K + E++ + ++ Q+V+A++YL + + PIIH+DLKP NIL+VD G+IK+TDFGLSKI D + DG++LTSQGAGTYWYLPPECFV P I +KVDVWS+GV F+QCLYGRKPFGH+Q+Q DIL NTI A V F P S+ AK FI +CL Y ++DR + QL + YL P +
Sbjct: 252 KLLIEKSTQEKQACREKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLVKQQEWIIQQREEIERQRKLLAKRKPPSASSSQSPSTNSEPKQRKTKAVNGSENDPFLKPSLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDSSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLIEQRYAAVKIHQLNKNWREEKKENYHKHACREYRIHKQLDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMTEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDNYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPSKPVASNEAKAFIRRCLAYRKEDRFDVHQLGSDSYLLPHI 714
BLAST of Tousled-like kinase vs. Ensembl Zebrafish
Match: tlk1b (tousled-like kinase 1b [Source:NCBI gene;Acc:326734]) HSP 1 Score: 412.535 bits (1059), Expect = 1.246e-134 Identity = 224/462 (48.48%), Postives = 304/462 (65.80%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPV-----------------------GDRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S +E+ + K +RL+LG + TVRHG Y +++ G F + +++ I +Q+E+ E++RK L K KP D KP L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE++S+F D PTLNERY++L LLG+GGFSEVYKAFDL +QR+ A K H+LN+NW EKK++Y +H RE +I K L+HPRIV ++D F++D+DTF VLE+C+GNDLDFYLKQ+K + E++ + ++ Q+V+A++YL + + PIIH+DLKP NIL+VD G+IK+TDFGLSKI D DG++LTSQGAGTYWYLPPECFV P I +KVDVWS+GV F+QCLYGRKPFGH+Q+Q DIL NTI A V F P S+ AK FI +CL Y ++DR + QL + YL P +
Sbjct: 271 KLLIEKSTQEKQSCREKSMQDRLRLGHFTTVRHGASYSEQWTDGYAFQNLVKQQEWINQQREEIERQRKLLAKRKPPSTPSSQSPTPNESKQRKTKAVNGADNDPFLKPSLPTLLTVAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDSSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLFEQRYAAVKIHQLNKNWREEKKENYHKHACREYRIHKQLDHPRIVKLYDYFSLDTDTFCTVLEFCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPAKPVASNEAKAFIRRCLAYRKEDRFDVHQLGSDSYLLPHM 732
BLAST of Tousled-like kinase vs. Ensembl Xenopus
Match: ccdc89 (coiled-coil domain containing 89 [Source:Xenbase;Acc:XB-GENE-5853491]) HSP 1 Score: 419.468 bits (1077), Expect = 4.993e-139 Identity = 225/456 (49.34%), Postives = 307/456 (67.32%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGKPRAN-----------------PELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S +E+ ++ K +RL+LG + TVRHG + +++ G F + +++ + +Q+ED E++RK L K KP P AN P + P E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLNERY++L LLG+GGFSEVYKAFDL +QR+ A K H+LN++W +EKK++Y +H RE +I K L+HPRIV ++D F++D+DTF VLEYC+GNDLDFYLKQ+K + E++ + ++ Q+V+A++YL + + PIIH+DLKP NIL+VD G+IK+TDFGLSKI D DG++LTSQGAGTYWYLPPECFV P I +KVDVWS+GV F+QCLYGRKPFGH+Q+Q DIL NTI A V F P VS+ AK FI +CL Y ++DR + QL YL P +
Sbjct: 129 KLLIEKSTQEKLASREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKQLAKRKPPSSNSS-QTPSANSEPKQRKNKAVNGAENDPFVKPTEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSNEAKAFIRRCLAYRKEDRFDVHQLANDAYLLPHM 583
BLAST of Tousled-like kinase vs. Ensembl Xenopus
Match: cbfb (core-binding factor subunit beta [Source:Xenbase;Acc:XB-GENE-1016003]) HSP 1 Score: 417.927 bits (1073), Expect = 5.912e-139 Identity = 230/456 (50.44%), Postives = 311/456 (68.20%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGK-PRANPE---------------LDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIF-PDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ I Q+E+ E++RK L K KP +G+ P AN E L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + + PIIH+DLKP NIL+V+ G+IK+TDFGLSKI DS + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRKPFGH+Q+Q DIL NTI A V F P P V+ AK FI +CL Y ++DR + QL YL P +
Sbjct: 96 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINTQREEIERQRKMLAKRKPPA----MGQTPPANNEQKQRKNKTNGAENEALTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMTEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 547
BLAST of Tousled-like kinase vs. Ensembl Xenopus
Match: cbfb (core-binding factor subunit beta [Source:Xenbase;Acc:XB-GENE-1016003]) HSP 1 Score: 417.927 bits (1073), Expect = 1.420e-138 Identity = 230/456 (50.44%), Postives = 311/456 (68.20%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGK-PRANPE---------------LDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIF-PDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ I Q+E+ E++RK L K KP +G+ P AN E L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + + PIIH+DLKP NIL+V+ G+IK+TDFGLSKI DS + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRKPFGH+Q+Q DIL NTI A V F P P V+ AK FI +CL Y ++DR + QL YL P +
Sbjct: 122 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINTQREEIERQRKMLAKRKPPA----MGQTPPANNEQKQRKNKTNGAENEALTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMTEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 573
BLAST of Tousled-like kinase vs. Ensembl Xenopus
Match: cbfb (core-binding factor subunit beta [Source:Xenbase;Acc:XB-GENE-1016003]) HSP 1 Score: 418.698 bits (1075), Expect = 2.286e-138 Identity = 230/456 (50.44%), Postives = 311/456 (68.20%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGK-PRANPE---------------LDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIF-PDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ I Q+E+ E++RK L K KP +G+ P AN E L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + + PIIH+DLKP NIL+V+ G+IK+TDFGLSKI DS + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRKPFGH+Q+Q DIL NTI A V F P P V+ AK FI +CL Y ++DR + QL YL P +
Sbjct: 161 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINTQREEIERQRKMLAKRKPPA----MGQTPPANNEQKQRKNKTNGAENEALTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMTEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 612
BLAST of Tousled-like kinase vs. Ensembl Xenopus
Match: ccdc89 (coiled-coil domain containing 89 [Source:Xenbase;Acc:XB-GENE-5853491]) HSP 1 Score: 419.083 bits (1076), Expect = 2.540e-138 Identity = 225/456 (49.34%), Postives = 307/456 (67.32%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGKPRAN-----------------PELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S +E+ ++ K +RL+LG + TVRHG + +++ G F + +++ + +Q+ED E++RK L K KP P AN P + P E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLNERY++L LLG+GGFSEVYKAFDL +QR+ A K H+LN++W +EKK++Y +H RE +I K L+HPRIV ++D F++D+DTF VLEYC+GNDLDFYLKQ+K + E++ + ++ Q+V+A++YL + + PIIH+DLKP NIL+VD G+IK+TDFGLSKI D DG++LTSQGAGTYWYLPPECFV P I +KVDVWS+GV F+QCLYGRKPFGH+Q+Q DIL NTI A V F P VS+ AK FI +CL Y ++DR + QL YL P +
Sbjct: 178 KLLIEKSTQEKLASREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKQLAKRKPPSSNSS-QTPSANSEPKQRKNKAVNGAENDPFVKPTEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSNEAKAFIRRCLAYRKEDRFDVHQLANDAYLLPHM 632
BLAST of Tousled-like kinase vs. Ensembl Mouse
Match: Tlk2 (tousled-like kinase 2 (Arabidopsis) [Source:MGI Symbol;Acc:MGI:1346023]) HSP 1 Score: 419.083 bits (1076), Expect = 1.094e-137 Identity = 227/452 (50.22%), Postives = 306/452 (67.70%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG------------DRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIF-PDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ I Q+E+ E++RK L K KP R N L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + + PIIH+DLKP NIL+V+ G+IK+TDFGLSKI DS + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRKPFGH+Q+Q DIL NTI A V F P P V+ AK FI +CL Y ++DR + QL YL P +
Sbjct: 240 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 691
BLAST of Tousled-like kinase vs. Ensembl Mouse
Match: Tlk2 (tousled-like kinase 2 (Arabidopsis) [Source:MGI Symbol;Acc:MGI:1346023]) HSP 1 Score: 419.083 bits (1076), Expect = 1.094e-137 Identity = 227/452 (50.22%), Postives = 306/452 (67.70%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG------------DRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIF-PDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ I Q+E+ E++RK L K KP R N L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + + PIIH+DLKP NIL+V+ G+IK+TDFGLSKI DS + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRKPFGH+Q+Q DIL NTI A V F P P V+ AK FI +CL Y ++DR + QL YL P +
Sbjct: 240 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 691
BLAST of Tousled-like kinase vs. Ensembl Mouse
Match: Tlk2 (tousled-like kinase 2 (Arabidopsis) [Source:MGI Symbol;Acc:MGI:1346023]) HSP 1 Score: 419.083 bits (1076), Expect = 2.649e-137 Identity = 227/452 (50.22%), Postives = 306/452 (67.70%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG------------DRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIF-PDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ I Q+E+ E++RK L K KP R N L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + + PIIH+DLKP NIL+V+ G+IK+TDFGLSKI DS + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRKPFGH+Q+Q DIL NTI A V F P P V+ AK FI +CL Y ++DR + QL YL P +
Sbjct: 272 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 723
BLAST of Tousled-like kinase vs. Ensembl Mouse
Match: Tlk1 (tousled-like kinase 1 [Source:MGI Symbol;Acc:MGI:2441683]) HSP 1 Score: 415.231 bits (1066), Expect = 1.380e-135 Identity = 233/488 (47.75%), Postives = 318/488 (65.16%), Query Frame = 1
Query: 487 RELSDHQKI---EKENLIKS-------LIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKP----------VGDRGKLGKPRA--NPELDPY------------EFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
R++ D QK+ KE L K LIE S +E+ ++ K +RL+LG + TVRHG + +++ G F + +++ + +Q+ED E++RK L K KP K K +A E DP+ E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLNERY++L LLG+GGFSEVYKAFDL +QR+ A K H+LN++W +EKK++Y +H RE +I K L+HPRIV ++D F++D+DTF VLEYC+GNDLDFYLKQ+K + E++ + ++ Q+V+A++YL + + PIIH+DLKP NIL+VD G+IK+TDFGLSKI D DG++LTSQGAGTYWYLPPECFV P I +KVDVWS+GV F+QCLYGRKPFGH+Q+Q DIL NTI A V F P VS AK FI +CL Y ++DR + QL YL P +
Sbjct: 251 RQIDDQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLGKRKPPTANNSQAPATNSEAKQRKTKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHM 738
BLAST of Tousled-like kinase vs. Ensembl Mouse
Match: Tlk2 (tousled-like kinase 2 (Arabidopsis) [Source:MGI Symbol;Acc:MGI:1346023]) HSP 1 Score: 355.14 bits (910), Expect = 6.762e-114 Identity = 195/386 (50.52%), Postives = 266/386 (68.91%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG------------DRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIF-PDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRK 1638
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ I Q+E+ E++RK L K KP R N L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + + PIIH+DLKP NIL+V+ G+IK+TDFGLSKI DS + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRK
Sbjct: 208 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRK 593
BLAST of Tousled-like kinase vs. UniProt/SwissProt
Match: sp|Q1ECX4|TLK2_DANRE (Serine/threonine-protein kinase tousled-like 2 OS=Danio rerio OX=7955 GN=tlk2 PE=2 SV=2) HSP 1 Score: 421.394 bits (1082), Expect = 6.015e-138 Identity = 226/451 (50.11%), Postives = 306/451 (67.85%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG------------DRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ + Q+E+ E++RK L K KP R N L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + R PIIH+DLKP NIL+V+ G+IK+TDFGLSKI D + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYG+KPFGH+Q+Q DIL NTI A V F P P VS AK FI +CL Y ++DR + QL + YL P +
Sbjct: 220 KLLIEKSKQEKIACREKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLVKQQERVNGQREEIERQRKLLIKKKPPSASQTPPPNLEPNKRKSKSNGAENEMLSLAEYHEQEEIFKLRLGHLKKEEAEIQVELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQVVNALKYLNEIRPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDNYGVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGKKPFGHNQSQQDILQENTILKATEVQFPPKPGVSPEAKAFIRRCLVYRKEDRIDVHQLASDPYLLPHI 670
BLAST of Tousled-like kinase vs. UniProt/SwissProt
Match: sp|O55047|TLK2_MOUSE (Serine/threonine-protein kinase tousled-like 2 OS=Mus musculus OX=10090 GN=Tlk2 PE=1 SV=2) HSP 1 Score: 419.083 bits (1076), Expect = 7.652e-137 Identity = 227/452 (50.22%), Postives = 306/452 (67.70%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG------------DRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIF-PDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ I Q+E+ E++RK L K KP R N L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + + PIIH+DLKP NIL+V+ G+IK+TDFGLSKI DS + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRKPFGH+Q+Q DIL NTI A V F P P V+ AK FI +CL Y ++DR + QL YL P +
Sbjct: 240 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 691
BLAST of Tousled-like kinase vs. UniProt/SwissProt
Match: sp|Q08CW1|TLK2_XENTR (Serine/threonine-protein kinase tousled-like 2 OS=Xenopus tropicalis OX=8364 GN=tlk2 PE=2 SV=1) HSP 1 Score: 417.542 bits (1072), Expect = 1.664e-136 Identity = 230/456 (50.44%), Postives = 311/456 (68.20%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGK-PRANPE---------------LDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIF-PDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ I Q+E+ E++RK L K KP +G+ P AN E L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + + PIIH+DLKP NIL+V+ G+IK+TDFGLSKI DS + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRKPFGH+Q+Q DIL NTI A V F P P V+ AK FI +CL Y ++DR + QL YL P +
Sbjct: 219 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINTQREEIERQRKMLAKRKPPA----MGQTPPANNEQKQRKNKTNGAENEALTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMTEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHI 670
BLAST of Tousled-like kinase vs. UniProt/SwissProt
Match: sp|Q8C0V0|TLK1_MOUSE (Serine/threonine-protein kinase tousled-like 1 OS=Mus musculus OX=10090 GN=Tlk1 PE=1 SV=2) HSP 1 Score: 415.231 bits (1066), Expect = 9.655e-135 Identity = 233/488 (47.75%), Postives = 318/488 (65.16%), Query Frame = 1
Query: 487 RELSDHQKI---EKENLIKS-------LIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKP----------VGDRGKLGKPRA--NPELDPY------------EFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
R++ D QK+ KE L K LIE S +E+ ++ K +RL+LG + TVRHG + +++ G F + +++ + +Q+ED E++RK L K KP K K +A E DP+ E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLNERY++L LLG+GGFSEVYKAFDL +QR+ A K H+LN++W +EKK++Y +H RE +I K L+HPRIV ++D F++D+DTF VLEYC+GNDLDFYLKQ+K + E++ + ++ Q+V+A++YL + + PIIH+DLKP NIL+VD G+IK+TDFGLSKI D DG++LTSQGAGTYWYLPPECFV P I +KVDVWS+GV F+QCLYGRKPFGH+Q+Q DIL NTI A V F P VS AK FI +CL Y ++DR + QL YL P +
Sbjct: 251 RQIDDQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLGKRKPPTANNSQAPATNSEAKQRKTKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHM 738
BLAST of Tousled-like kinase vs. UniProt/SwissProt
Match: sp|Q9UKI8|TLK1_HUMAN (Serine/threonine-protein kinase tousled-like 1 OS=Homo sapiens OX=9606 GN=TLK1 PE=1 SV=2) HSP 1 Score: 412.535 bits (1059), Expect = 1.195e-133 Identity = 224/463 (48.38%), Postives = 308/463 (66.52%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKP-VGDRGKLGKPRANP-----------ELDPY------------EFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S +E+ ++ K +RL+LG + TVRHG + +++ G F + +++ + +Q+ED E++RK L K KP + + + P E DP+ E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLNERY++L LLG+GGFSEVYKAFDL +QR+ A K H+LN++W +EKK++Y +H RE +I K L+HPRIV ++D F++D+DTF VLEYC+GNDLDFYLKQ+K + E++ + ++ Q+V+A++YL + + PIIH+DLKP NIL+VD G+IK+TDFGLSKI D DG++LTSQGAGTYWYLPPECFV P I +KVDVWS+GV F+QCLYGRKPFGH+Q+Q DIL NTI A V F P VS AK FI +CL Y ++DR + QL YL P +
Sbjct: 276 KLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHM 738
BLAST of Tousled-like kinase vs. TrEMBL
Match: A0A158QHF1 (Protein kinase domain-containing protein OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS7311 PE=4 SV=1) HSP 1 Score: 475.322 bits (1222), Expect = 2.777e-153 Identity = 261/506 (51.58%), Postives = 353/506 (69.76%), Query Frame = 1
Query: 391 PTSKL--DGLVTSTIKSGSSVADRLMIQRLEKENRELSDHQKIEKENLIKS--------------LIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILI----VDGDIKVTDFGLSKIFPDSDTTAD-GIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV*LK 1845
PT+ + GL I SVA ++ L + +L + +++L ++ LIE S ER + KV N+RL+LG++VT R GVH+E+K+V G++F E++ +RK IE+ KE+ E+KRK NK KP D K + R + E+ EF+ Q E ++ K L KEDKE+ +ELE L R +N H+RE+KR+ NE+ASRF D P LN+RY++L+LLGKGGFSEV+K FDLQ+ R+VACK H+LN W +KKD+YI+H LREI+I K+LNH RIV V DVF++D D F V EYC+GNDLDF+LKQNK +PER+ K +I Q++SA+KYL +R+ P+IH+DLKP NIL+ + G+IK+TDFGLSK+ + T D G++LTSQGAGTYWYLPPECF T P I SKVD+WS+G+ F+QCLYGRKPFGH+ +Q DIL+ NTI A+ + F +PKVSDAAK+FI +C TY ++ RP +FQL DYL+PK LK
Sbjct: 382 PTTPVVPSGLALQQIPGSPSVAPLSLVDSLNRRLADLEMENEFNRKSLQEATDVSVRSRQIIRDLLIEKSVLERKTTRQKVMNDRLRLGQFVTQRQGVHFEEKWVEGNRFKELDQRRKQIEEVKEEIERKRKQWNKRKPGADNRKNSRARCD-EVSVDEFYEQMEIYDLRKQLLLKEDKEITSELERLDRERNLHIREIKRIANEDASRFKDHPLLNDRYLLLNLLGKGGFSEVHKGFDLQENRYVACKIHQLNATWPKDKKDNYIKHALREIEIHKTLNHQRIVKVFDVFDIDHDAFCTVQEYCEGNDLDFFLKQNKVIPEREAKSIICQVISALKYLNERKPPVIHYDLKPGNILLGSGEMSGEIKITDFGLSKLMTEDLYTPDIGMDLTSQGAGTYWYLPPECFETGREPPKISSKVDIWSVGIIFFQCLYGRKPFGHNMSQADILHQNTILHARQIIFPTSPKVSDAAKDFIRRCCTYQKELRPDVFQLCNDDYLKPKAQLK 886
BLAST of Tousled-like kinase vs. TrEMBL
Match: A0A564YFW3 (Protein kinase domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS5482 PE=4 SV=1) HSP 1 Score: 474.552 bits (1220), Expect = 7.399e-153 Identity = 258/498 (51.81%), Postives = 349/498 (70.08%), Query Frame = 1
Query: 409 GLVTSTIKSGSSVADRLMIQRLEKENRELSDHQKIEKENLIKS--------------LIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILI----VDGDIKVTDFGLSKIFPDSDTTAD-GIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV*LK 1845
GL I S+A ++ L + +L + +++L ++ LIE S ER + KV N+RL+LG++VT R GVH+E+K+V G++F E++ +RK IE+ KE+ E+KRK NK KP D K + R + E+ EF+ Q E ++ K L KEDKE+ +ELE L R +N H+RE+KR+ NE+ASRF D P LN+RY++L+LLGKGGFSEV+K FDLQ+ R+VACK H+LN W +KKD+YI+H LREI+I K+LNH RIV V DVF++D D F V EYC+GNDLDF+LKQNK +PER+ K +I Q++SA+KYL +R+ P+IH+DLKP NIL+ + G+IK+TDFGLSK+ + T D G++LTSQGAGTYWYLPPECF T P I SKVD+WS+G+ F+QCLYGRKPFGH+ +Q DIL+ NTI A+ + F +PKVSDAAK+FI +C TY ++ RP +FQL DYL+PK LK
Sbjct: 394 GLTLQQIPGSPSIAPLNLVDSLNRRIADLEVENEFNRKSLQEAAEASVRSRQIIRDLLIEKSVLERKTTRQKVMNDRLRLGQFVTQRQGVHFEEKWVEGNRFKELDQRRKQIEEVKEEIERKRKQWNKRKPGADNRKNSRARCD-EVSVDEFYEQMEIYDLRKQLLLKEDKEITSELERLDRERNLHIREIKRIANEDASRFKDHPLLNDRYLLLNLLGKGGFSEVHKGFDLQENRYVACKIHQLNATWPKDKKDNYIKHALREIEIHKTLNHQRIVKVFDVFDIDHDAFCTVQEYCEGNDLDFFLKQNKVIPEREAKSIICQVISALKYLNERKPPVIHYDLKPGNILLGSGEMSGEIKITDFGLSKLMTEDLYTPDIGMDLTSQGAGTYWYLPPECFETGREPPKISSKVDIWSVGIIFFQCLYGRKPFGHNMSQADILHQNTILHARQIIFPTSPKVSDAAKDFIRRCCTYQKELRPDVFQLCNDDYLKPKAQLK 890
BLAST of Tousled-like kinase vs. TrEMBL
Match: A0A0R3X460 (Protein kinase domain-containing protein OS=Hydatigena taeniaeformis OX=6205 GN=TTAC_LOCUS8166 PE=4 SV=1) HSP 1 Score: 473.396 bits (1217), Expect = 3.452e-152 Identity = 264/507 (52.07%), Postives = 352/507 (69.43%), Query Frame = 1
Query: 394 TSKLDGLVTSTIK-------SGSSVADRLMIQR----LEKENRELSDHQKIEKENLIKS-------LIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILI----VDGDIKVTDFGLSKIFPDSDTTAD-GIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV*LK 1845
TS ++TST+ SGSS+ +QR LE EN + E+ +KS LIE S ER + KV ++RL+LG+++T R GVH+E+K+V G +F E++ +RK IE +E+ E+KRK NK KP + K K R E+ EF+ Q E ++ K L KEDKE+ +ELE L R +N H+RE+KR+ NE+ASRF D P LNERY++L+LLGKGGFSEV+K FDLQ+ R+VACK H+LN W +KKD+YI+H LREI+I K+LNH RIV V DVF++D D F + EYC+GNDLDF+LKQNK +PER+ K +I Q++SA+KYL R+ P+IH+DLKP NIL+ + G+IK+TDFGLSK+ + D G++LTSQGAGTYWYLPPECF T P I SKVD+WS+G+ F+QCL+G+KPFGH+ +Q DIL+ NTI A+S+AF PKVSD AKEFI +C TY ++ RP +FQL+ DYL+PK LK
Sbjct: 405 TSSAPAMLTSTMPLQQASTVSGSSINLVESLQRRISELELENCAQKQTIALANEHSLKSRQIIQDLLIEKSLLERKTTRQKVMDDRLRLGQFITQRQGVHFEEKWVEGYRFKELDARRKNIEGIREEIERKRKQWNKRKPGSENKKNSKARWE-EVSVDEFYEQIEIYDLRKQMLAKEDKEIQSELERLDRERNLHIREIKRIANEDASRFKDHPLLNERYLLLNLLGKGGFSEVHKGFDLQENRYVACKIHQLNPAWPKDKKDNYIKHALREIEIHKTLNHQRIVKVFDVFDIDHDAFCTIQEYCEGNDLDFFLKQNKVIPEREAKSIICQVISALKYLNQRKPPVIHYDLKPGNILLGSGEISGEIKITDFGLSKLMTEDLYNPDTGMDLTSQGAGTYWYLPPECFETGHEPPKISSKVDIWSVGIIFFQCLFGKKPFGHNMSQADILHQNTILHARSIAFPSTPKVSDGAKEFIRKCCTYQKELRPNVFQLYNDDYLKPKAQLK 910
BLAST of Tousled-like kinase vs. TrEMBL
Match: A0A5K3F4P7 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1) HSP 1 Score: 466.463 bits (1199), Expect = 9.627e-152 Identity = 255/473 (53.91%), Postives = 337/473 (71.25%), Query Frame = 1
Query: 463 IQRLEKENRELSDHQKIEKENLIKS-------LIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILI----VDGDIKVTDFGLSKIFPDSDTTAD-GIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV*LK 1845
I LE EN + +E+ +KS LIE S ER + KV +NRL+LG++VT R GVH+E+K++ G +F E++ +RK IE +E+ E+K+K NK KP + K K R E+ EF+ Q E ++ K L KEDKE+ +ELE L R +N H+RE+KR+ NE+ASRF D P LNERY++L+LLGKGGFSEV+K FDLQ+ R+VACK H+LN W +KKD+YI+H LREI+I K+LNH RIV V DVF++D D F V EYC+GNDLDF+LKQNK +PER+ K +I Q++SA+KYL R+ P+IH+DLKP NIL+ + G+IK+TDFGLSK+ + D G++LTSQGAGTYWYLPPECF T P I SKVD+WS+G+ F+QCL+G+KPFGH+ +Q DIL+ NTI A+S+ F PKVSDAAKEFI +C TY ++ RP +FQL DYL+PK LK
Sbjct: 253 IAELEVENTAQRQAIALAQEHSLKSRQLIQDLLIEKSLLERKTTRQKVMDNRLRLGQFVTQRQGVHFEEKWIEGYRFKELDARRKNIESIREEIERKKKQWNKRKPGSESRKNSKTRWE-EVSVDEFYEQIEIYDLRKQMLVKEDKEIQSELERLDRERNLHIREIKRIANEDASRFKDHPLLNERYLLLNLLGKGGFSEVHKGFDLQENRYVACKIHQLNPAWPKDKKDNYIKHALREIEIHKTLNHQRIVKVFDVFDIDHDAFCTVQEYCEGNDLDFFLKQNKIIPEREAKSIICQVISALKYLNQRKPPVIHYDLKPGNILLGSGELSGEIKITDFGLSKLMTEDLYNPDTGMDLTSQGAGTYWYLPPECFETGREPPKISSKVDIWSVGIIFFQCLFGKKPFGHNMSQADILHQNTILHARSIVFPSVPKVSDAAKEFIRKCCTYQKELRPDVFQLFNDDYLKPKAQLK 724
BLAST of Tousled-like kinase vs. TrEMBL
Match: A0A0R3WEC1 (Protein kinase domain-containing protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS9157 PE=4 SV=1) HSP 1 Score: 472.241 bits (1214), Expect = 9.900e-152 Identity = 261/494 (52.83%), Postives = 346/494 (70.04%), Query Frame = 1
Query: 412 LVTSTIKSGSSVADRLMIQR----LEKENRELSDHQKIEKENLIKS-------LIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILI----VDGDIKVTDFGLSKIFPDSDTTAD-GIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV*LK 1845
L S SGSS+ +QR LE EN + E+ +KS LIE S ER + KV ++RL+LG+++T R GVH+E+K+V G +F E++ +RK IE +E+ E+KRK NK KP + K K R E+ EF+ Q E ++ K L KEDKE+ +ELE L R +N H+RE+KR+ NE+ASRF D P LNERY++L+LLGKGGFSEV+K FDLQ+ R+VACK H+LN W +KKD+YI+H LREI+I K+LNH RIV V DVF++D D F + EYC+GNDLDF+LKQNK +PER+ K +I Q++SA+KYL R+ P+IH+DLKP NIL+ + G+IK+TDFGLSK+ + D G++LTSQGAGTYWYLPPECF T P I SKVD+WS+G+ F+QCL+G+KPFGH+ +Q DIL+ NTI A+S+AF PKVSD AKEFI +C TY ++ RP +FQL+ DYL+PK LK
Sbjct: 417 LQQSATVSGSSINLVESLQRRISELELENCAQKQTIALANEHSLKSRQIIQDLLIEKSLLERKTTRQKVMDDRLRLGQFITQRQGVHFEEKWVEGYRFKELDARRKNIEGIREEIERKRKQWNKRKPGSENKKNSKARWE-EVSVDEFYEQIEIYDLRKQMLAKEDKEIQSELERLDRERNLHIREIKRIANEDASRFKDHPLLNERYLLLNLLGKGGFSEVHKGFDLQENRYVACKIHQLNPAWPKDKKDNYIKHALREIEIHKTLNHQRIVKVFDVFDIDHDAFCTIQEYCEGNDLDFFLKQNKVIPEREAKSIICQVISALKYLNQRKPPVIHYDLKPGNILLGSGEISGEIKITDFGLSKLMTEDLYNPDTGMDLTSQGAGTYWYLPPECFETGHEPPKISSKVDIWSVGIIFFQCLFGKKPFGHNMSQADILHQNTILHARSIAFPSTPKVSDGAKEFIRKCCTYQKELRPNVFQLYNDDYLKPKAQLK 909
BLAST of Tousled-like kinase vs. Ensembl Cavefish
Match: tlk2 (tousled like kinase 2 [Source:NCBI gene;Acc:103043685]) HSP 1 Score: 419.083 bits (1076), Expect = 9.416e-140 Identity = 226/451 (50.11%), Postives = 306/451 (67.85%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG------------DRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ + Q+ED E++RK L K KP R N L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + R PIIH+DLKP NIL+V+ G+IK+TDFGLSKI D + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYG+KPFGH+Q+Q DIL NTI A V F P P VS AK FI +CL Y ++DR + QL + +L P +
Sbjct: 89 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWSDGYAFQNLIKQQERVNSQREDIERQRKLLAKKKPPSASQTPPPSLEPNKRKNKSNGAENEMLSLAEYHEQEEIFKLRLGHLKKEEAEIQVELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEGRSIIMQVVNALKYLNEIRPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDNYGVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGKKPFGHNQSQQDILQENTILKATEVQFPPKPGVSPEAKAFIRRCLVYRKEDRIDVHQLASDPFLLPHI 539
BLAST of Tousled-like kinase vs. Ensembl Cavefish
Match: tlk2 (tousled like kinase 2 [Source:NCBI gene;Acc:103043685]) HSP 1 Score: 420.239 bits (1079), Expect = 7.501e-139 Identity = 226/451 (50.11%), Postives = 306/451 (67.85%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG------------DRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ + Q+ED E++RK L K KP R N L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + R PIIH+DLKP NIL+V+ G+IK+TDFGLSKI D + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYG+KPFGH+Q+Q DIL NTI A V F P P VS AK FI +CL Y ++DR + QL + +L P +
Sbjct: 187 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWSDGYAFQNLIKQQERVNSQREDIERQRKLLAKKKPPSASQTPPPSLEPNKRKNKSNGAENEMLSLAEYHEQEEIFKLRLGHLKKEEAEIQVELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEGRSIIMQVVNALKYLNEIRPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDNYGVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGKKPFGHNQSQQDILQENTILKATEVQFPPKPGVSPEAKAFIRRCLVYRKEDRIDVHQLASDPFLLPHI 637
BLAST of Tousled-like kinase vs. Ensembl Cavefish
Match: tlk2 (tousled like kinase 2 [Source:NCBI gene;Acc:103043685]) HSP 1 Score: 420.624 bits (1080), Expect = 1.464e-138 Identity = 226/451 (50.11%), Postives = 306/451 (67.85%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG------------DRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ + Q+ED E++RK L K KP R N L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + R PIIH+DLKP NIL+V+ G+IK+TDFGLSKI D + DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYG+KPFGH+Q+Q DIL NTI A V F P P VS AK FI +CL Y ++DR + QL + +L P +
Sbjct: 220 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWSDGYAFQNLIKQQERVNSQREDIERQRKLLAKKKPPSASQTPPPSLEPNKRKNKSNGAENEMLSLAEYHEQEEIFKLRLGHLKKEEAEIQVELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEGRSIIMQVVNALKYLNEIRPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDNYGVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGKKPFGHNQSQQDILQENTILKATEVQFPPKPGVSPEAKAFIRRCLVYRKEDRIDVHQLASDPFLLPHI 670
BLAST of Tousled-like kinase vs. Ensembl Cavefish
Match: tlk1a (tousled like kinase 1 [Source:NCBI gene;Acc:103028257]) HSP 1 Score: 418.698 bits (1075), Expect = 5.379e-137 Identity = 227/464 (48.92%), Postives = 309/464 (66.59%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGKPRANPEL-------------DPY------------EFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S +E+ + K +RL+LG++ TVRHG + +++ G F + +++ I +Q+ED E++RK L K KP P AN E DP+ E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE++S+F D PTLNERY++L LLG+GGFSEVYKAFDL +QR+ A K H+LN+NW EKK++Y +H RE +I K L+HPRIV ++D F++D+DTF VLEYC+GNDLDFYLKQ+K + E++ + ++ Q+V+A++YL + + PIIH+DLKP NIL+VD G+IK+TDFGLSKI D + DG++LTSQGAGTYWYLPPECFV P I +KVDVWS+GV F+QCLYGRKPFGH+Q+Q DIL NTI A V F P S+ AK FI +CL Y ++DR + QL + YL P +
Sbjct: 286 KLLIEKSTQEKQACREKSMQDRLRLGQFATVRHGASFTEQWTDGYAFQNLIKQQESINQQREDIERQRKLLAKRKPPSASNS-QTPNANSEPKQRKTKAVNGAENDPFLKPSLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDSSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLIEQRYAAVKIHQLNKNWREEKKENYHKHACREYRIHKQLDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDNYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVASNEAKAFIRRCLAYRKEDRFDVHQLGSDSYLLPHM 748
BLAST of Tousled-like kinase vs. Ensembl Cavefish
Match: tlk1a (tousled like kinase 1 [Source:NCBI gene;Acc:103028257]) HSP 1 Score: 417.927 bits (1073), Expect = 7.611e-137 Identity = 227/464 (48.92%), Postives = 309/464 (66.59%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGKPRANPEL-------------DPY------------EFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S +E+ + K +RL+LG++ TVRHG + +++ G F + +++ I +Q+ED E++RK L K KP P AN E DP+ E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE++S+F D PTLNERY++L LLG+GGFSEVYKAFDL +QR+ A K H+LN+NW EKK++Y +H RE +I K L+HPRIV ++D F++D+DTF VLEYC+GNDLDFYLKQ+K + E++ + ++ Q+V+A++YL + + PIIH+DLKP NIL+VD G+IK+TDFGLSKI D + DG++LTSQGAGTYWYLPPECFV P I +KVDVWS+GV F+QCLYGRKPFGH+Q+Q DIL NTI A V F P S+ AK FI +CL Y ++DR + QL + YL P +
Sbjct: 267 KLLIEKSTQEKQACREKSMQDRLRLGQFATVRHGASFTEQWTDGYAFQNLIKQQESINQQREDIERQRKLLAKRKPPSASNS-QTPNANSEPKQRKTKAVNGAENDPFLKPSLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDSSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLIEQRYAAVKIHQLNKNWREEKKENYHKHACREYRIHKQLDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDNYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVASNEAKAFIRRCLAYRKEDRFDVHQLGSDSYLLPHM 729
BLAST of Tousled-like kinase vs. Ensembl Sea Lamprey
Match: TLK1 (tousled like kinase 1 [Source:HGNC Symbol;Acc:HGNC:11841]) HSP 1 Score: 426.017 bits (1094), Expect = 5.255e-141 Identity = 233/454 (51.32%), Postives = 313/454 (68.94%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKP-----------VGDRGKLGKPRANPELDPYEFFIQSEKIEINKVRX---XXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTA-DGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG +VTVRHG + +++ GS F + +++ I +Q+ED E++RK L K KP G++ + N ++ E+ EI K+RL KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLNERY++L LLG+GGFSEVYKAFDLQ+QR+VA K H+LN+NW +EKK++Y +H RE +I K LNHPRIV ++D F++D+D+F VLEY +GNDLDFYLKQ+K + E++ + +I Q+VSA+KYL + + PIIH+DLKP NIL+VD G+IK+TDFGLSKI D + A DG++LTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRKPFGH+Q+Q DIL TI A V F P VS+ AK FI +CL Y ++DR + QL YL P +
Sbjct: 243 KLLIEKSEQEKQACREKSMQDRLRLGHFVTVRHGATFTEQWTDGSAFQNLIKQQEWINQQREDIERQRKLLAKRKPPTAGHSASPMPAGEQKQRKTKAVNGAVNRLTVAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLQEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELNHPRIVKLYDYFSLDTDSFCTVLEYIEGNDLDFYLKQHKLMSEKEARSIIMQIVSALKYLNEIKPPIIHYDLKPGNILLVDGKSCGEIKITDFGLSKIMDDDNYNAVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQEKTILRATEVQFPVKPVVSNEAKAFIRRCLAYRKEDRIDVHQLAGDLYLMPHI 696
BLAST of Tousled-like kinase vs. Ensembl Sea Lamprey
Match: TLK1 (tousled like kinase 1 [Source:HGNC Symbol;Acc:HGNC:11841]) HSP 1 Score: 421.009 bits (1081), Expect = 4.323e-139 Identity = 229/463 (49.46%), Postives = 310/463 (66.95%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPV-----------------------GDRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTA-DGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K L+E S++E+ + K +RL+LG +VTVRHG + +++ GS F + +++ + +Q+ED E++RK L K KP G KP P L E+ Q E +++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDLQ+QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEY GNDLDFYLKQ+K + E++ + +I Q+VSA+KYL + + PIIH+DLKP NIL+VD G+IK+TDFGLSKI D + A DG++LTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRKPFGH+Q+Q DIL TI A V F P S+ AK FI +CL Y ++DR + QL + YL P +
Sbjct: 237 KLLVEKSEQEKQACREKSMQDRLRLGHFVTVRHGATFTEQWTDGSAFQNLIKQQEWVNQQREDIERQRKLLAKRKPPMAAHMTSPASAAEQKQRKNKAVNGADDNFVKPSVPPTLTVAEYHEQEEILKLRLGHLKKEEAEIQAELERLERTRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLQEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYIHGNDLDFYLKQHKLMSEKEARSIIMQIVSALKYLNEIKPPIIHYDLKPGNILLVDGKSCGEIKITDFGLSKIMDDENYNAVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQEKTILRATEVQFPVKPVASNEAKAFIRRCLAYRKEDRIHVQQLASDLYLMPHI 699
BLAST of Tousled-like kinase vs. Ensembl Sea Lamprey
Match: TLK1 (tousled like kinase 1 [Source:HGNC Symbol;Acc:HGNC:11841]) HSP 1 Score: 421.394 bits (1082), Expect = 7.768e-139 Identity = 237/472 (50.21%), Postives = 314/472 (66.53%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPV------------------------GDRGKLGKPRANPELDPY--------EFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTA-DGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG +VTVRHG + +++ GS F + +++ I +Q+ED E++RK L K KP D G L KP A P+L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLNERY++L LLG+GGFSEVYKAFDLQ+QR+VA K H+LN+NW +EKK++Y +H RE +I K LNHPRIV ++D F++D+D+F VLEY +GNDLDFYLKQ+K + E++ + +I Q+VSA+KYL + + PIIH+DLKP NIL+VD G+IK+TDFGLSKI D + A DG++LTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRKPFGH+Q+Q DIL TI A V F P VS+ AK FI +CL Y ++DR + QL YL P +
Sbjct: 264 KLLIEKSEQEKQACREKSMQDRLRLGHFVTVRHGATFTEQWTDGSAFQNLIKQQEWINQQREDIERQRKLLAKRKPPTAGHSASPMPAGEQKQRKTKAVNGADEGFL-KP-ATPQLSHVSLNRLTVAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLQEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELNHPRIVKLYDYFSLDTDSFCTVLEYIEGNDLDFYLKQHKLMSEKEARSIIMQIVSALKYLNEIKPPIIHYDLKPGNILLVDGKSCGEIKITDFGLSKIMDDDNYNAVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQEKTILRATEVQFPVKPVVSNEAKAFIRRCLAYRKEDRIDVHQLAGDLYLMPHI 733
BLAST of Tousled-like kinase vs. Ensembl Sea Lamprey
Match: plk3 (polo-like kinase 3 (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-030131-6134]) HSP 1 Score: 108.227 bits (269), Expect = 6.437e-25 Identity = 82/273 (30.04%), Postives = 129/273 (47.25%), Query Frame = 1
Query: 1015 LLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVDG-DIKVTDFGLSKIFPDSDTTADGIELTSQG-AGTYWYLPPECFVTDG-GPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYL 1824
LLGKGGF+ Y L + + C F +K + +EI + + L+H IV F D + ++LE C+G L L+ K L E + K + QL+S ++YL + ++H DLK N + D ++K+ D GL+ TT + E+ + GT YL PE G GP+ D+WS+G + L GR PF + +D+ NT +S F P +S AA++ +T LT + R ++ L +H +L
Sbjct: 32 LLGKGGFARCY----LVTEEYTGCHFAAKIITKQRVEKPGHRAKIEQEISLHRKLHHRHIVQFISSFK-DENFIYIILELCNGQSLAHMLRSRKVLTETEVKYYLRQLISGLRYL--HQCGVVHRDLKLGNFFVTDSMEVKIGDLGLA-------TTLEPPEMRKRTVCGTPNYLAPEVLNKRGHGPE-----ADIWSLGCAVFTMLAGRPPF----STSDL--ANTYACIRSGRFNFPPSLSHAARDLLTSALTPDPDLRASLLDLQSHPFL 279
BLAST of Tousled-like kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001278.1 (pep scaffold:Pmarinus_7.0:GL476529:253165:339525:-1 gene:ENSPMAG00000001147.1 transcript:ENSPMAT00000001278.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 99.7525 bits (247), Expect = 1.515e-23 Identity = 69/233 (29.61%), Postives = 117/233 (50.21%), Query Frame = 1
Query: 1153 REIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD-----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYN-RQDRPTIFQLHAHDYLRPK 1833
RE+ I + L HP I+ +H+V+ D+D ++LE G +L +L + L E + + Q++ V YL RR I HFDLKP NI++++ +K+ DFGL++ + DG+E GT ++ PE + + P + + D+WSIGV Y L G PF D + + N + + + + S AK FI + L + ++R + + H +++PK
Sbjct: 45 REVSILRELRHPNIISLHEVYENDTDV-TLILELVSGGELFDFLAHKESLSEDEATEFLKQILDGVSYLHCRR--IAHFDLKPENIMLLENRAPKAHVKIIDFGLAQ------SIVDGVEF-RHIFGTPEFVVPE--IVNYEP--LGVQADMWSIGVMTYILLSGASPFLGDTKEETLSNISAVEYKFDEEYF--KQTSALAKNFIQRLLLKSPNRERMNVEEAIHHPWIKPK 261
BLAST of Tousled-like kinase vs. Ensembl Yeast
Match: CDC5 (Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants [Source:SGD;Acc:S000004603]) HSP 1 Score: 108.997 bits (271), Expect = 2.453e-25 Identity = 81/273 (29.67%), Postives = 131/273 (47.99%), Query Frame = 1
Query: 1015 LLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILI-VDGDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRL-AKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLR 1827
LG+GGF+ ++ D + F A + + K + + L EIQI KS++HP IV D F DS+ +++ LE C L LK+ K L E + + Q+ A+KY+ RR +IH DLK NI + ++K+ DFGL+ + A+ E GT Y+ PE + + VD+WS+GV Y L G+ PF Q +N R+ + +F + +SD K I L+ + +RP++ ++ + + R
Sbjct: 87 FLGEGGFARCFQIKDDSGEIFAAKTVAK-----ASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYIL-LEICPNGSLMELLKRRKVLTEPEVRFFTTQICGAIKYMHSRR--VIHRDLKLGNIFFDSNYNLKIGDFGLAAVL------ANESERKYTICGTPNYIAPEVLMGKHSGHSFE--VDIWSLGVMLYALLIGKPPF-----QARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIMDYVWFR 338
BLAST of Tousled-like kinase vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931]) HSP 1 Score: 104.76 bits (260), Expect = 2.317e-24 Identity = 86/281 (30.60%), Postives = 130/281 (46.26%), Query Frame = 1
Query: 1000 YVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKC--LPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILI-VDGDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPE--CFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLR 1827
Y + S +G+G F +VYKA D Q VA K L E D I +EI L P I D ++ V+EYC G LK++ LPE +I ++ +KYL ++R IH D+K +NIL+ +G +K+ DFG+S S D GT +++ PE C DG + K D+WS+G+ Y+ L G P ++ D + T + L P SDAAK+F+ CL DRP+ + L + ++++
Sbjct: 18 YSIQSCIGRGNFGDVYKAVDRVTQEIVAIKVVNL------EHSDEDIELLAQEIFFLAELKSPLITNYIATMLEDVSMWI-VMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQRK--IHRDIKAANILLNEEGMVKLGDFGVSGHI-RSTLKRDTF------VGTPYWMAPEVVCCEVDG----YNEKADIWSLGITTYELLKGLPPL----SKYDPMKVMTNLPKRKPPKLQGP-FSDAAKDFVAGCLVKTPADRPSAYNLLSFEFVK 273
BLAST of Tousled-like kinase vs. Ensembl Yeast
Match: SNF1 (AMP-activated S/T protein kinase; forms a complex with Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; regulates nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth and acts as a non-canonical GEF, activating Arf3p during invasive growth; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ub ligase [Source:SGD;Acc:S000002885]) HSP 1 Score: 100.138 bits (248), Expect = 1.410e-22 Identity = 87/277 (31.41%), Postives = 131/277 (47.29%), Query Frame = 1
Query: 1000 YVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVDG-DIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLR 1827
Y ++ LG+G F +V A+ + VA K +N+ K D R REI + L HP I+ ++DV D +MV+EY GN+L Y+ Q + E++ + Q++SAV+Y R I+H DLKP N+L+ + ++K+ DFGLS I D + G+ Y PE G +VDVWS GV Y L R PF D +L N ++ V LP +S A I + L N +R +I ++ D+ +
Sbjct: 55 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKI--INKK-VLAKSDMQGRIE-REISYLRLLRHPHIIKLYDVIK-SKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEYC--HRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGN-------FLKTSCGSPNYAAPEVI---SGKLYAGPEVDVWSCGVILYVMLCRRLPF--DDESIPVLFKN---ISNGVYTLPK-FLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFK 307
BLAST of Tousled-like kinase vs. Ensembl Yeast
Match: RAD53 (DNA damage response protein kinase; required for cell-cycle arrest, regulation of copper genes in response to DNA damage; phosphorylates nuclear pores to counteract gene gating, preventing aberrant transitions at forks approaching transcribed genes; activates downstream kinase Dun1p; differentially senses mtDNA depletion, mitochondrial ROS; relocalizes to cytosol under hypoxia; human homolog CHEK2 implicated in breast cancer can complement yeast null mutant [Source:SGD;Acc:S000006074]) HSP 1 Score: 100.138 bits (248), Expect = 2.406e-22 Identity = 84/299 (28.09%), Postives = 139/299 (46.49%), Query Frame = 1
Query: 970 FNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVDGD---IKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFV---TDGGPQIID------SKVDVWSIGVNFYQCLYGRKPF-GHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLR 1827
F DF ++E ++G+G F+ V KA + + A K + K + RE+++ + LNHPRIV + + D++++ MV+E+ G DL ++ + + E + + Q+++A+KY+ I H DLKP NILI D +K+TDFGL+K+ + GT Y+ PE T P + S VD+WS+G Y L G PF G Q Q L R + L + ++S+ A++FI L + +R T + H +++
Sbjct: 194 FKDFSIIDE------VVGQGAFATVKKAIERTTGKTFAVKI------ISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFYE-DTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYI--HSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNG-------SFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQ---LYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIK 467
BLAST of Tousled-like kinase vs. Ensembl Yeast
Match: YPL150W_mRNA (Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study [Source:SGD;Acc:S000006071]) HSP 1 Score: 99.7525 bits (247), Expect = 3.122e-22 Identity = 85/284 (29.93%), Postives = 135/284 (47.54%), Query Frame = 1
Query: 1000 YVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILI-VDGDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECF---VTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHD---QTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRP 1830
Y +L +G+G F +VY A R V K T++K D I +RE+ + + P I +++V +S + M LEYC G +L +L + + +C L AQ+ AV Y +H DLK NIL+ +G+ K+TDFG ++ + TT + + GT Y+ PE DG K+D+WS+GV Y + G PF D +T+ I+N AK + D A++ I++ L N +RP++ Q+ H +L+P
Sbjct: 41 YKILKQIGEGSFGKVYLALHRPTHRKVCLK--------TSDKNDPNI---VREVFYHRQFDFPYITKLYEVIVTESKVW-MALEYCPGKELYDHLLSLRRISLLECGELFAQISGAVYYAHSMH--CVHRDLKLENILLDKNGNAKLTDFGFTRECM-TKTTLETV------CGTTVYMAPELIERRTYDG------FKIDIWSLGVILYTLITGYLPFDDDDEAKTKWKIVNEEPKYDAKVIP--------DDARDLISRLLAKNPGERPSLSQVLRHPFLQP 289
BLAST of Tousled-like kinase vs. Ensembl Nematostella
Match: EDO37283 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SG68]) HSP 1 Score: 382.874 bits (982), Expect = 1.732e-127 Identity = 215/436 (49.31%), Postives = 287/436 (65.83%), Query Frame = 1
Query: 592 NRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKED------------------NEKKRKALNKCKPVGDRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIV-----DGDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRP 1830
NRL+LG++V VR G + + G F E+ +++ I +++E+ +KK + + K D G+ +P +P L P E++ + E +++ L KE+ EL EL+ L R ++ H+RE+KR+++E+ SRF + P LN +Y++LSLLGKGGFSEVYK +DL R+VACK H+L + W +KK +YI+H LRE I KSLNHPRIV ++DVF +D ++F VLEYCDGNDLDF LKQ+K +PER+ K ++ Q V A+KYL + + P+IH+DLKP NIL+V G+ K+TDFGLSKIF +SD D +ELTSQGAGTYWYLPPECFV P I SKVDVWS+GV FYQ LYGRKPFGHDQTQ IL N TI A+ V F P VS AK FI +CL Y + DR + L YL+P
Sbjct: 16 NRLRLGQFVPVRQGAQFVDSWSEGYAFKELNKQQEKINQKREELEKQKKLLVKKKPSSGATGKKKMRFIYKKGKSSD-GEFTRP-LSPVLSPMEYYEKEEILKLRAAALKKEETELQLELDKLDRERSLHIREIKRLQHEDNSRFKNHPKLNNQYLLLSLLGKGGFSEVYKGYDLVNHRYVACKIHQLIKEWKEDKKANYIKHALREYNIHKSLNHPRIVQLYDVFEIDVESFCTVLEYCDGNDLDFLLKQHKTVPEREAKCIVMQTVRALKYLNEIKPPVIHYDLKPGNILLVGTGAFSGETKITDFGLSKIF-ESDED-DSMELTSQGAGTYWYLPPECFVVGKEPPKISSKVDVWSVGVIFYQMLYGRKPFGHDQTQASILENRTILKAREVEFPAKPVVSSEAKNFIRRCLAYRKDDRADVLTLCDDVYLKP 447
BLAST of Tousled-like kinase vs. Ensembl Nematostella
Match: EDO28073 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T7H8]) HSP 1 Score: 139.428 bits (350), Expect = 4.004e-39 Identity = 76/124 (61.29%), Postives = 84/124 (67.74%), Query Frame = 1
Query: 1402 SNILIV-----DGDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRK----PFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAK 1746
NIL+V G+ K+TDFGLSKIF +SD D +ELTSQGAGTYWYLPPECFV P I SKVDVWS+GV FYQ LYGR+ PFGHDQTQ IL N TI A+ V F P VS AK
Sbjct: 1 GNILLVGTGAFSGETKITDFGLSKIF-ESDED-DSMELTSQGAGTYWYLPPECFVVGKEPPKISSKVDVWSVGVIFYQMLYGRRYGQYPFGHDQTQASILENRTILKAREVEFPAKPVVSSEAK 122
BLAST of Tousled-like kinase vs. Ensembl Nematostella
Match: EDO41399 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4I8]) HSP 1 Score: 118.627 bits (296), Expect = 1.597e-29 Identity = 80/285 (28.07%), Postives = 140/285 (49.12%), Query Frame = 1
Query: 982 PTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIV---DGDIKVTDFGLS-KIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYL 1824
P +N +VV LG+G ++ VYKAF R V + + ++ L EI++ ++L H IV + D F D + +++EYC G DL ++ + LPER + + QL A++Y+ R + H DLKP N+L+ + +K+ DFG + K+ P+S+ S G+ Y+ PE Q D+ VD+WS+GV Y+ L+G PF +++T + +R ++ + P P+VS ++ + L + + R + H ++
Sbjct: 12 PKIN-NFVVAEKLGQGSYATVYKAFKKGDNRDVVAIKCIKKKTLSKAATENL----LTEIELLRNLEHEHIVQLKD-FQWDENHIFLIMEYCGGGDLSRFIHSKRALPERMARKFLRQLACALQYM--RSYDVAHMDLKPQNLLLSSRHNPVLKIADFGFAQKLHPNSE--------ASNIRGSPLYMAPEMICC----QSYDASVDLWSVGVILYETLFGEPPF---KSKTFVELEAKLRSSEPIKLPPGPRVSADCRDLLIALLQRDPKQRISFEAFFTHPFI 273
BLAST of Tousled-like kinase vs. Ensembl Nematostella
Match: EDO44613 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVB0]) HSP 1 Score: 119.783 bits (299), Expect = 1.203e-28 Identity = 103/316 (32.59%), Postives = 145/316 (45.89%), Query Frame = 1
Query: 907 TRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVDGD----IKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPK-----VSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLR 1827
T+ K +E+ + + E A+ DF ++Y + LLG+G F EV AF A K Q + + I+ E+ I K+LNHP I+ + DVF D +VLE +G +L + K E KLL Q+V AV+YL + I H DLKP NIL+ +K+TDFG+SK+ + L GT YL PE + G VD WS+G Y CL G PF + D+ N + LA F PK VSD A + I + LT + R TI Q+ H +++
Sbjct: 165 TKNKAYIFQELGKSQEEVANIPEDF---RKKYTLSKLLGRGAFGEVRLAFTKGTCHKFAVKLISKRQFSVSPVSHASIKD---EVNILKALNHPCIIEIADVFE-SPDMLYIVLELVEGGELFDRVVSVKRFEESVAKLLFYQMVVAVEYLHSKG--ITHRDLKPENILLCSDKNETLLKITDFGVSKMVGEQS-------LMKTLCGTPSYLAPE-VLRSAGLGGYSKAVDCWSLGCMLYICLGGYAPFSDEVEPYDV---NKLILAGKYTF---PKQHWKCVSDEAIDLIKKLLTVDPSKRLTIQQVLEHPWIK 457
BLAST of Tousled-like kinase vs. Ensembl Nematostella
Match: EDO33022 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STC5]) HSP 1 Score: 112.849 bits (281), Expect = 1.058e-27 Identity = 88/285 (30.88%), Postives = 140/285 (49.12%), Query Frame = 1
Query: 1000 YVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVDGD-------IKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNP---KVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYL 1824
Y + +GKG F +V K +LQ + A K E++ + + E K + E +I L+HP IV + DVF ++VLEY G DL + E+D + Q++ A++YLT R IIH DLKP N+L+ + IK+TDFG++K +G G+ YL PE + +G + VD+W+ GV Y L G PF ++QT+ +L+ + +S P+P VS+ AK+ I + L + +DR T + H+++
Sbjct: 7 YEITDFIGKGAFGQVSKCVNLQTREVFAVK--EIDFSGSEEDK----KKAQNEAKICGLLDHPSIVHLEDVF-FTPRRMLLVLEYLPGGDLFDGVVTRTQFSEKDACACVRQVLKALRYLT--RKGIIHRDLKPENLLLSERPSDHRPPIIKLTDFGIAKQL--------------KGNGSPLYLAPETILEEG----LTYAVDIWACGVILYLLLVGYPPFWNEQTEFLLLS-----ILQSNYTFPSPYWDTVSEPAKDLIRKMLVVDPRDRITAVEALKHEWV 259
BLAST of Tousled-like kinase vs. Ensembl Medaka
Match: tlk2 (tousled like kinase 2 [Source:NCBI gene;Acc:101158767]) HSP 1 Score: 418.313 bits (1074), Expect = 4.975e-138 Identity = 229/452 (50.66%), Postives = 309/452 (68.36%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG-----------DRGKLGKPRANPE-LDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTA-DGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ I Q+ED E++RK L K KP ++ K A E L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + R PIIH+DLKP NIL+V+ G+IK+TDFGLSKI D A DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRKPFGH+Q+Q DIL NTI A V F P P V+ AK FI +CL Y ++DR + QL + +L P +
Sbjct: 188 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREDIERQRKLLAKRKPPSMAQTPPPSLEQNKRKSKTNGAESETLSQAEYHEQEEIFKLRLGYLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEGRSIIMQIVNALKYLNEIRPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNAVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATDVQFPPKPVVTPEAKAFIRRCLVYRKEDRIDVHQLASDPFLMPHI 639
BLAST of Tousled-like kinase vs. Ensembl Medaka
Match: tlk2 (tousled like kinase 2 [Source:NCBI gene;Acc:101158767]) HSP 1 Score: 416.772 bits (1070), Expect = 2.067e-137 Identity = 229/452 (50.66%), Postives = 309/452 (68.36%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG-----------DRGKLGKPRANPE-LDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTA-DGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ I Q+ED E++RK L K KP ++ K A E L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + R PIIH+DLKP NIL+V+ G+IK+TDFGLSKI D A DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRKPFGH+Q+Q DIL NTI A V F P P V+ AK FI +CL Y ++DR + QL + +L P +
Sbjct: 190 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREDIERQRKLLAKRKPPSMAQTPPPSLEQNKRKSKTNGAESETLSQAEYHEQEEIFKLRLGYLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEGRSIIMQIVNALKYLNEIRPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNAVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATDVQFPPKPVVTPEAKAFIRRCLVYRKEDRIDVHQLASDPFLMPHI 641
BLAST of Tousled-like kinase vs. Ensembl Medaka
Match: tlk2 (tousled like kinase 2 [Source:NCBI gene;Acc:101158767]) HSP 1 Score: 417.157 bits (1071), Expect = 2.864e-137 Identity = 229/452 (50.66%), Postives = 309/452 (68.36%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVG-----------DRGKLGKPRANPE-LDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTA-DGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S++E+ + K +RL+LG + TVRHG + +++ G F + +++ I Q+ED E++RK L K KP ++ K A E L E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE+ S+F D PTLN+RY++L LLG+GGFSEVYKAFDL +QR+VA K H+LN+NW +EKK++Y +H RE +I K L+HPRIV ++D F++D+D+F VLEYC+GNDLDFYLKQ+K + E++ + +I Q+V+A+KYL + R PIIH+DLKP NIL+V+ G+IK+TDFGLSKI D A DG+ELTSQGAGTYWYLPPECFV P I +KVDVWS+GV FYQCLYGRKPFGH+Q+Q DIL NTI A V F P P V+ AK FI +CL Y ++DR + QL + +L P +
Sbjct: 221 KLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREDIERQRKLLAKRKPPSMAQTPPPSLEQNKRKSKTNGAESETLSQAEYHEQEEIFKLRLGYLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEGRSIIMQIVNALKYLNEIRPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNAVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATDVQFPPKPVVTPEAKAFIRRCLVYRKEDRIDVHQLASDPFLMPHI 672
BLAST of Tousled-like kinase vs. Ensembl Medaka
Match: tlk1b (serine/threonine-protein kinase tousled-like 1-B [Source:NCBI gene;Acc:101169144]) HSP 1 Score: 418.698 bits (1075), Expect = 3.063e-137 Identity = 227/464 (48.92%), Postives = 308/464 (66.38%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRG------KLGKPR-----------ANPELDP--------YEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S +E+ + K +RL+LG + TVRHG Y +++ G F + +++ I +Q+ED E++RK L K KP +P+ ++P L P E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE++S F D PTLNERY++L LLG+GGFSEVYKAFDL +QR+ A K H+LN+NW EKK++Y +H RE +I K L+HPRIV ++D F++D+DTF VLE+C+GNDLDFYLKQNK + E++ + ++ Q+VSA++YL + + PIIH+DLKP NIL+VD G+IK+TDFGLSKI D + DG++LTSQGAGTYWYLPPECFV P I +KVDVWS+GV F+QCLYGRKPFGH+Q+Q DIL NTI A V F P+ S AK FI +CL Y ++DR + QL + YL P +
Sbjct: 264 KLLIEKSNQEKLSCREKSMQDRLRLGHFTTVRHGASYTEQWTDGYAFQNLIKQQESINQQREDIERQRKLLAKRKPPNPAAPSLSVASTSEPKQRKAKVVNGNDSDPFLKPSLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDSSAFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLFEQRYAAVKIHQLNKNWREEKKENYHKHACREYRIHKQLDHPRIVKLYDYFSLDTDTFCTVLEFCEGNDLDFYLKQNKLMSEKEARSIVMQIVSALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDNYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPAKPQASTEAKAFIRRCLAYRKEDRYDVHQLCSDSYLLPHM 727
BLAST of Tousled-like kinase vs. Ensembl Medaka
Match: tlk1a (tousled like kinase 1 [Source:NCBI gene;Acc:101159625]) HSP 1 Score: 417.542 bits (1072), Expect = 3.099e-137 Identity = 226/463 (48.81%), Postives = 310/463 (66.95%), Query Frame = 1
Query: 532 KSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCK----------PVGDRGKLGKPRA--NPELDPY------------EFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD----GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
K LIE S +E+ + K +RL+LG + TVRHG + +++ G F +I +++ I +Q+ED E++RK L K K K K +A E DP+ E+ Q E ++ L KE+ E+ ELE L R +N H+RE+KR+ NE++S+F D PTLNERY++L LLG+GGFSEVYKAFDL +QR+ A K H+LN+NW EKK++Y +H RE +I K L+HPRIV ++D F++D+DTF V+E+C+GNDLDFYLKQ+K + E++ + ++ Q+V+A+KYL + + PIIH+DLKP NIL+VD G+IK+TDFGLSKI D + DG++LTSQGAGTYWYLPPECFV P I +KVDVWS+G+ F+QCLYGRKPFGH+Q+Q DIL NTI A V F P VS+ AK FI +CL Y ++DR + QL + YL P +
Sbjct: 227 KLLIEKSTQEKQACREKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQKIVKQQEWINQQREDIERQRKLLAKRKPPSSSSSQAPATNSESKQRKTKAVNGAESDPFLKPSLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDSSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLIEQRYAAVKIHQLNKNWREEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVMEFCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALKYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDNYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGIIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSNEAKAFIRRCLAYRKEDRSDVHQLGSDLYLLPHI 689
BLAST of Tousled-like kinase vs. Planmine SMEST
Match: SMESG000026492.1 (SMESG000026492.1) HSP 1 Score: 1214.91 bits (3142), Expect = 0.000e+0 Identity = 602/604 (99.67%), Postives = 604/604 (100.00%), Query Frame = 1
Query: 25 MESTNNEHKNDEICGPDINANQSDSTNELSGLFPIFANIRENSISTEKSASNFGNEPVACQALVSYNLSKQSNHRLLTNKEMSSPNRKIIRKRRAVSISHQSKLICKRAEKPIDEIYKSHQQPTSKLDGLVTSTIKSGSSVADRLMIQRLEKENRELSDHQKIEKENLIKSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVDGDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
MESTNNEHKNDEICGPDINANQSDSTNELSGLFPIFANIRENSISTEKSASNFGNEPVACQALVSYNLSKQSNHRLLTNKEMSSPNRKIIRKRRAVSISHQSKLICKRAEKPIDEIYKSHQQPTSKLDGLVTSTIKSGS+VADRLMIQRLEKENRELSDHQKIEKENLIKSLIENSQRER+VNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGKPRANPELDPYEFFIQSEKIEINKVRLNKEDKELDNELELLTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVDGDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV
Sbjct: 1 MESTNNEHKNDEICGPDINANQSDSTNELSGLFPIFANIRENSISTEKSASNFGNEPVACQALVSYNLSKQSNHRLLTNKEMSSPNRKIIRKRRAVSISHQSKLICKRAEKPIDEIYKSHQQPTSKLDGLVTSTIKSGSTVADRLMIQRLEKENRELSDHQKIEKENLIKSLIENSQREREVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGKLGKPRANPELDPYEFFIQSEKIEINKVRLNKEDKELDNELELLTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVDGDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 604
BLAST of Tousled-like kinase vs. Planmine SMEST
Match: SMESG000026488.1 (SMESG000026488.1) HSP 1 Score: 567.77 bits (1462), Expect = 0.000e+0 Identity = 276/458 (60.26%), Postives = 358/458 (78.17%), Query Frame = 1
Query: 478 KENRELSDHQKIEKENLIKSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGK-LGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIV-DGDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV*LK 1845
KEN +L D+++ +E LIK+L++ S+ ER + +V+NN+L LG++ + R G HYE+K+ G K+ ++E KRK IE+Q+++NEK++K NK KP ++ K GK + +PEL+P EF+ Q+E +I KV +NKE+K+L E E L R +N H+RE+KR++NEEASRF DFP LN+RY++LSLLGKGGFSEV+K FDL+Q FVACK HELN +W +KKDSYI+H LREI I K L+H RIV VHDVFN+D+D F VLEYC+GNDLDFYLKQNKC+PERD K LI QLVSA++YL DR+ PIIH+DLKP NIL+ +G+IK+TDFGLSKIFPD +G+ELTSQGAGTYWYLPPECFVT+ GP I SKVDVWS+GV FYQ LYG+KPFG++ TQTDIL+NNTI A+++ F PK+SD AK+FI +C TY ++ RP +FQL DYL+PK LK
Sbjct: 328 KENEQLKDYRRKAREVLIKTLMQQSELERRATRERVNNNKLHLGQFKSFRQGAHYEEKWSEGLKYQDLEKKRKWIEEQRDENEKRKKMWNKRKPASEKTKQTGKQKGSPELEPNEFYWQAEIHDIRKVNINKEEKDLQAETERLDRERNLHIREIKRIDNEEASRFRDFPILNDRYLILSLLGKGGFSEVHKGFDLEQLCFVACKIHELNPSWPQDKKDSYIKHALREISIHKRLDHRRIVRVHDVFNIDNDAFCTVLEYCEGNDLDFYLKQNKCIPERDAKSLICQLVSALRYLNDRKNPIIHYDLKPGNILLCNNGEIKITDFGLSKIFPDDHHNPEGMELTSQGAGTYWYLPPECFVTENGPPTISSKVDVWSVGVIFYQSLYGKKPFGNNMTQTDILHNNTILQARNINFPSFPKISDGAKDFIRRCCTYRKELRPDVFQLCNDDYLKPKAQLK 785
BLAST of Tousled-like kinase vs. Planmine SMEST
Match: SMESG000026488.1 (SMESG000026488.1) HSP 1 Score: 567.385 bits (1461), Expect = 0.000e+0 Identity = 276/458 (60.26%), Postives = 358/458 (78.17%), Query Frame = 1
Query: 478 KENRELSDHQKIEKENLIKSLIENSQRERDVNKLKVHNNRLQLGEYVTVRHGVHYEQKFVPGSKFVEIEWKRKLIEKQKEDNEKKRKALNKCKPVGDRGK-LGKPRANPELDPYEFFIQSEKIEINKVRXXXXXXXXXXXXXXXTRAKNSHLREMKRVENEEASRFNDFPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIV-DGDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV*LK 1845
KEN +L D+++ +E LIK+L++ S+ ER + +V+NN+L LG++ + R G HYE+K+ G K+ ++E KRK IE+Q+++NEK++K NK KP ++ K GK + +PEL+P EF+ Q+E +I KV +NKE+K+L E E L R +N H+RE+KR++NEEASRF DFP LN+RY++LSLLGKGGFSEV+K FDL+Q FVACK HELN +W +KKDSYI+H LREI I K L+H RIV VHDVFN+D+D F VLEYC+GNDLDFYLKQNKC+PERD K LI QLVSA++YL DR+ PIIH+DLKP NIL+ +G+IK+TDFGLSKIFPD +G+ELTSQGAGTYWYLPPECFVT+ GP I SKVDVWS+GV FYQ LYG+KPFG++ TQTDIL+NNTI A+++ F PK+SD AK+FI +C TY ++ RP +FQL DYL+PK LK
Sbjct: 326 KENEQLKDYRRKAREVLIKTLMQQSELERRATRERVNNNKLHLGQFKSFRQGAHYEEKWSEGLKYQDLEKKRKWIEEQRDENEKRKKMWNKRKPASEKTKQTGKQKGSPELEPNEFYWQAEIHDIRKVNINKEEKDLQAETERLDRERNLHIREIKRIDNEEASRFRDFPILNDRYLILSLLGKGGFSEVHKGFDLEQLCFVACKIHELNPSWPQDKKDSYIKHALREISIHKRLDHRRIVRVHDVFNIDNDAFCTVLEYCEGNDLDFYLKQNKCIPERDAKSLICQLVSALRYLNDRKNPIIHYDLKPGNILLCNNGEIKITDFGLSKIFPDDHHNPEGMELTSQGAGTYWYLPPECFVTENGPPTISSKVDVWSVGVIFYQSLYGKKPFGNNMTQTDILHNNTILQARNINFPSFPKISDGAKDFIRRCCTYRKELRPDVFQLCNDDYLKPKAQLK 783
BLAST of Tousled-like kinase vs. Planmine SMEST
Match: SMESG000027403.1 (SMESG000027403.1) HSP 1 Score: 118.242 bits (295), Expect = 7.773e-29 Identity = 93/297 (31.31%), Postives = 147/297 (49.49%), Query Frame = 1
Query: 979 FPTLNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACKFHE-----LNQNWTNEKKDSYI-RHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILI----VDGDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDI-LNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYLRPKV 1836
FP N RY ++ LGKGGF EV K D++ FVA K + ++ + +++D I R LRE ++ +SLNH I+ + +V ++ F+ +++ +G DL + K ERD L+ Q++SAV+++ + +H DLKP NIL D I +TDFGLS+ + E GT Y PE + + +VD+WSIGV Y L G PF + T+ D + + IR + +S AK+F+T L DR T+ + H +L+ ++
Sbjct: 11 FPE-NSRYKIIEELGKGGFCEVLKGRDVKNDFFVAIKRVDKTKPFFSKASSPQERDKKIKRMMLREARVMQSLNHVNIIKLIEVIEDKNEVFI-IMDLAEGGDLFDRIISMKRFAERDAAKLLEQILSAVQHM--HQCGFVHRDLKPENILFKSRDKDSSILLTDFGLSR---------EASEFMMTNCGTLDYSAPELLLNRRDRKGYGPEVDIWSIGVMAYILLCGFAPF-YSTTRDDTEIRSKIIRGDYKFSSPTWDTISHTAKDFVTYLLKVRPGDRMTLDKAIKHLWLKEQL 293
BLAST of Tousled-like kinase vs. Planmine SMEST
Match: SMESG000078361.1 (SMESG000078361.1) HSP 1 Score: 114.39 bits (285), Expect = 1.454e-27 Identity = 89/290 (30.69%), Postives = 137/290 (47.24%), Query Frame = 1
Query: 988 LNERYVVLSLLGKGGFSEVYKAFDLQQQRFVACK--------FHELNQNWTNEKKDSYIRHGLREIQIQKSLNHPRIVGVHDVFNVDSDTFVMVLEYCDGNDLDFYLKQNKCLPERDCKLLIAQLVSAVKYLTDRRTPIIHFDLKPSNILIVD---GDIKVTDFGLSKIFPDSDTTADGIELTSQGAGTYWYLPPECFVTDGGPQIIDSKVDVWSIGVNFYQCLYGRKPFGHDQTQTDILNNNTIRLAKSVAFLPNPKVSDAAKEFITQCLTYNRQDRPTIFQLHAHDYL 1824
+ +RYVV LLG+GGF V+KA+D + VA K + + N N EK + + RE + ++L+H I+ + D + D +VLEY DG +L+ L + K PE +I+Q+++ VKY+ D + +H D+K NIL D + +TDFGLSK ++G+ T+ GT Y PE D +D W+IG+ Y + GR PF Q + L S + S AK FI + L N ++R ++ H +L
Sbjct: 12 IAQRYVVDKLLGEGGFCVVFKAYDKETGVKVAIKRMDKTKPLYRKFNTNKAMEKLNKLM---YREADVMRALDHKNIIRLLDFID-DGHHIYLVLEYADGGELNSRLIKMKRFPENYVICIISQVINGVKYMHD--SGYVHRDIKAENILFKDRTNSVVLITDFGLSKF-------SEGVLYTN--CGTLVYSAPELLKNKKFKSGYDKMIDNWAIGILTYLLMCGRLPFEDLQQNENKLIQKICVGRVSFPYSEWTNASSIAKRFILKLLETNPENRMSLRDALEHRFL 286 The following BLAST results are available for this feature:
BLAST of Tousled-like kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Tousled-like kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Tousled-like kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Tousled-like kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Tousled-like kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Tousled-like kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Tousled-like kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Tousled-like kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Tousled-like kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Tousled-like kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Tousled-like kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Tousled-like kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Tousled-like kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Tousled-like kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30024332 ID=SMED30024332|Name=Tousled-like kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=1848bpback to top protein sequence of SMED30024332-orf-1 >SMED30024332-orf-1 ID=SMED30024332-orf-1|Name=SMED30024332-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=605bp MESTNNEHKNDEICGPDINANQSDSTNELSGLFPIFANIRENSISTEKSAback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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