Isocitrate dehydrogenase [NADP]

Overview
NameIsocitrate dehydrogenase [NADP]
Smed IDSMED30024309
Length (bp)1665
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Isocitrate dehydrogenase [NADP] (SMED30024309) t-SNE clustered cells

Violin plots show distribution of expression levels for Isocitrate dehydrogenase [NADP] (SMED30024309) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Isocitrate dehydrogenase [NADP] (SMED30024309) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Isocitrate dehydrogenase [NADP] (SMED30024309) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30024309

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 19

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
Smed sexual biotypeSMED30024309h1SMcG0016468 Contig48698uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30024309h1SMcG0016468 Contig48698newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30024309h1SMcG0016468 Contig34093newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30024309h1SMcG0016468 Contig34093uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30024309h1SMcG0016468 Contig24991newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30024309h1SMcG0016468 Contig24991uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
pharynxSMED30024309h1SMcG0016468 dd_Smed_v4_449_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30024309h1SMcG0016468 dd_Smed_v4_449_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30024309h1SMcG0016468 dd_Smed_v4_449_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30024309h1SMcG0016468 dd_Smed_v4_449_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30024309h1SMcG0016468 dd_Smed_v4_449_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30024309h1SMcG0016468 dd_Smed_v4_449_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30024309h1SMcG0016468 dd_Smed_v4_449_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30024309h1SMcG0016468 dd_Smed_v4_449_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30024309h1SMcG0016468 dd_Smed_v4_449_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30024309h1SMcG0016468 dd_Smed_v4_449_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Category 2 cellSMED30024309h1SMcG0016468 dd_Smed_v6_449_0dd_Smed_v6PMID:29674432
Plass et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30024309h1SMcG0016468 dd_Smed_v6_449_0dd_Smed_v6PMID:29674432
Plass et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30024309h1SMcG0016468 dd_Smed_v4_449_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Human
Match: IDH2 (isocitrate dehydrogenase (NADP(+)) 2 [Source:HGNC Symbol;Acc:HGNC:5383])

HSP 1 Score: 672.159 bits (1733), Expect = 0.000e+0
Identity = 316/411 (76.89%), Postives = 354/411 (86.13%), Query Frame = 1 
Query:   76 RFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVK-PEHYLNTMDFLEAIAENFE 1305
            R Y+  RI VA PVVE+DGDEMTRIIW+ IKE+LI P+V++  KY+DLGLP+RDQT+DQVTIDSA A  KY+V +KCATITPDE RV+EFKLKKMW SPNGTIRNILGGTVFREPIICK IPRLV GW + I IGRHAHGDQYKATD+VA + G  ++VFTP D S      V+ F   GGVGM MYNTDESI GFAHSCFQYAI KKWPLY+STKNTILK YDGRFKDIFQEI+D+ YK +FDK KIWYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLDGN++LI++  ++EK CV+TV+SG MTKDLAGCIHGL NVK  EH+LNT DFL+ I  N +
Sbjct:   37 RHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPA-GGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLD 446
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Human
Match: IDH2 (isocitrate dehydrogenase (NADP(+)) 2 [Source:HGNC Symbol;Acc:HGNC:5383])

HSP 1 Score: 651.744 bits (1680), Expect = 0.000e+0
Identity = 306/395 (77.47%), Postives = 343/395 (86.84%), Query Frame = 1 
Query:  124 LDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVK-PEHYLNTMDFLEAIAENFE 1305
            +DGDEMTRIIW+ IKE+LI P+V++  KY+DLGLP+RDQT+DQVTIDSA A  KY+V +KCATITPDE RV+EFKLKKMW SPNGTIRNILGGTVFREPIICK IPRLV GW + I IGRHAHGDQYKATD+VA + G  ++VFTP D S      V+ F   GGVGM MYNTDESI GFAHSCFQYAI KKWPLY+STKNTILK YDGRFKDIFQEI+D+ YK +FDK KIWYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLDGN++LI++  ++EK CV+TV+SG MTKDLAGCIHGL NVK  EH+LNT DFL+ I  N +
Sbjct:    1 MDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFP-AGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLD 394
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Human
Match: IDH1 (isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC Symbol;Acc:HGNC:5382])

HSP 1 Score: 610.142 bits (1572), Expect = 0.000e+0
Identity = 281/397 (70.78%), Postives = 332/397 (83.63%), Query Frame = 1 
Query:  115 VVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFE 1305
            VVE+ GDEMTRIIWE IKE+LIFPYV +D   YDLG+ +RD TNDQVT D+AEAI K+NVG+KCATITPDE+RV+EFKLK+MW SPNGTIRNILGGTVFRE IICK IPRLV GW + I+IGRHA+GDQY+ATD+V   PGK+E+ +TP D +   T  V  F+  GGV M MYN D+SIE FAHS FQ A++K WPLYLSTKNTILK+YDGRFKDIFQEIYD+QYK++F+  KIWYEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAHGTVTRHYR +QKG+ TSTNPIASIFAWTRGL HR KLD NKEL  + + +E+  ++T+++G MTKDLA CI GL NV+   YLNT +F++ + EN +
Sbjct:   10 VVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLK 406
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Human
Match: IDH1 (isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC Symbol;Acc:HGNC:5382])

HSP 1 Score: 610.142 bits (1572), Expect = 0.000e+0
Identity = 281/397 (70.78%), Postives = 332/397 (83.63%), Query Frame = 1 
Query:  115 VVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFE 1305
            VVE+ GDEMTRIIWE IKE+LIFPYV +D   YDLG+ +RD TNDQVT D+AEAI K+NVG+KCATITPDE+RV+EFKLK+MW SPNGTIRNILGGTVFRE IICK IPRLV GW + I+IGRHA+GDQY+ATD+V   PGK+E+ +TP D +   T  V  F+  GGV M MYN D+SIE FAHS FQ A++K WPLYLSTKNTILK+YDGRFKDIFQEIYD+QYK++F+  KIWYEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAHGTVTRHYR +QKG+ TSTNPIASIFAWTRGL HR KLD NKEL  + + +E+  ++T+++G MTKDLA CI GL NV+   YLNT +F++ + EN +
Sbjct:   10 VVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLK 406
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Human
Match: IDH1 (isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC Symbol;Acc:HGNC:5382])

HSP 1 Score: 610.142 bits (1572), Expect = 0.000e+0
Identity = 281/397 (70.78%), Postives = 332/397 (83.63%), Query Frame = 1 
Query:  115 VVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFE 1305
            VVE+ GDEMTRIIWE IKE+LIFPYV +D   YDLG+ +RD TNDQVT D+AEAI K+NVG+KCATITPDE+RV+EFKLK+MW SPNGTIRNILGGTVFRE IICK IPRLV GW + I+IGRHA+GDQY+ATD+V   PGK+E+ +TP D +   T  V  F+  GGV M MYN D+SIE FAHS FQ A++K WPLYLSTKNTILK+YDGRFKDIFQEIYD+QYK++F+  KIWYEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAHGTVTRHYR +QKG+ TSTNPIASIFAWTRGL HR KLD NKEL  + + +E+  ++T+++G MTKDLA CI GL NV+   YLNT +F++ + EN +
Sbjct:   10 VVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLK 406
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Celegans
Match: idh-2 (Isocitrate dehydrogenase [NADP] [Source:UniProtKB/TrEMBL;Acc:O17643])

HSP 1 Score: 622.854 bits (1605), Expect = 0.000e+0
Identity = 302/425 (71.06%), Postives = 345/425 (81.18%), Query Frame = 1 
Query:   40 MLSRISLRLICARFYSAT-------RISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGL-KNVKPEHYLNTMDFLEAI 1290
            MLSR++ R +      AT       +I V NPVV+LDGDEMTRIIW++IK +LI PY+++D KYYDLGL +RD+TNDQVTID+A AIL+++VGIKCATITPDE R+KEF LKKMWLSPNGTIRNILGGTVFREPI+CK IPRLV GW + I IGRHA GDQYK TD V      L+L+    D S  D   V+ FK  GGVG+AMYNTDESI+GFAHSCFQYA+ K+WPLYLSTKNTILK+YDGRFKDIFQ+IY+++Y+A+F   KIWYEHRLIDD VAQALKSSGGFVW CKNYDGDVQSDIVAQGYGSLGLM+SVLMCPDGKTIEAEAAHGTVTRHYREHQKG  TSTNPIASIFAWTRGL HRG LD N+ L  +   +EK+C+DTV+ GKMTKDL+ CIHG  K  +   YL T DFL AI
Sbjct:    1 MLSRLTSRNVLLARNVATAATQERQKIKVDNPVVDLDGDEMTRIIWKEIKNKLILPYLDLDIKYYDLGLEYRDETNDQVTIDAAHAILEHSVGIKCATITPDEARIKEFNLKKMWLSPNGTIRNILGGTVFREPILCKNIPRLVPGWTQPITIGRHAFGDQYKCTDLVIPSGSTLQLLVNKPDGSK-DVHNVYDFKKSGGVGLAMYNTDESIKGFAHSCFQYALMKQWPLYLSTKNTILKKYDGRFKDIFQDIYEKKYEADFKNNKIWYEHRLIDDQVAQALKSSGGFVWACKNYDGDVQSDIVAQGYGSLGLMSSVLMCPDGKTIEAEAAHGTVTRHYREHQKGNSTSTNPIASIFAWTRGLHHRGVLDNNEALKTFSLTLEKACIDTVEEGKMTKDLSICIHGTKKGTEKGAYLITEDFLSAI 424
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Celegans
Match: idh-2 (Isocitrate dehydrogenase [NADP] [Source:UniProtKB/TrEMBL;Acc:O17643])

HSP 1 Score: 622.854 bits (1605), Expect = 0.000e+0
Identity = 302/425 (71.06%), Postives = 345/425 (81.18%), Query Frame = 1 
Query:   40 MLSRISLRLICARFYSAT-------RISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGL-KNVKPEHYLNTMDFLEAI 1290
            MLSR++ R +      AT       +I V NPVV+LDGDEMTRIIW++IK +LI PY+++D KYYDLGL +RD+TNDQVTID+A AIL+++VGIKCATITPDE R+KEF LKKMWLSPNGTIRNILGGTVFREPI+CK IPRLV GW + I IGRHA GDQYK TD V      L+L+    D S  D   V+ FK  GGVG+AMYNTDESI+GFAHSCFQYA+ K+WPLYLSTKNTILK+YDGRFKDIFQ+IY+++Y+A+F   KIWYEHRLIDD VAQALKSSGGFVW CKNYDGDVQSDIVAQGYGSLGLM+SVLMCPDGKTIEAEAAHGTVTRHYREHQKG  TSTNPIASIFAWTRGL HRG LD N+ L  +   +EK+C+DTV+ GKMTKDL+ CIHG  K  +   YL T DFL AI
Sbjct:    1 MLSRLTSRNVLLARNVATAATQERQKIKVDNPVVDLDGDEMTRIIWKEIKNKLILPYLDLDIKYYDLGLEYRDETNDQVTIDAAHAILEHSVGIKCATITPDEARIKEFNLKKMWLSPNGTIRNILGGTVFREPILCKNIPRLVPGWTQPITIGRHAFGDQYKCTDLVIPSGSTLQLLVNKPDGSK-DVHNVYDFKKSGGVGLAMYNTDESIKGFAHSCFQYALMKQWPLYLSTKNTILKKYDGRFKDIFQDIYEKKYEADFKNNKIWYEHRLIDDQVAQALKSSGGFVWACKNYDGDVQSDIVAQGYGSLGLMSSVLMCPDGKTIEAEAAHGTVTRHYREHQKGNSTSTNPIASIFAWTRGLHHRGVLDNNEALKTFSLTLEKACIDTVEEGKMTKDLSICIHGTKKGTEKGAYLITEDFLSAI 424
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Celegans
Match: idh-2 (Isocitrate dehydrogenase [NADP] [Source:UniProtKB/TrEMBL;Acc:O17643])

HSP 1 Score: 622.854 bits (1605), Expect = 0.000e+0
Identity = 302/425 (71.06%), Postives = 345/425 (81.18%), Query Frame = 1 
Query:   40 MLSRISLRLICARFYSAT-------RISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGL-KNVKPEHYLNTMDFLEAI 1290
            MLSR++ R +      AT       +I V NPVV+LDGDEMTRIIW++IK +LI PY+++D KYYDLGL +RD+TNDQVTID+A AIL+++VGIKCATITPDE R+KEF LKKMWLSPNGTIRNILGGTVFREPI+CK IPRLV GW + I IGRHA GDQYK TD V      L+L+    D S  D   V+ FK  GGVG+AMYNTDESI+GFAHSCFQYA+ K+WPLYLSTKNTILK+YDGRFKDIFQ+IY+++Y+A+F   KIWYEHRLIDD VAQALKSSGGFVW CKNYDGDVQSDIVAQGYGSLGLM+SVLMCPDGKTIEAEAAHGTVTRHYREHQKG  TSTNPIASIFAWTRGL HRG LD N+ L  +   +EK+C+DTV+ GKMTKDL+ CIHG  K  +   YL T DFL AI
Sbjct:    1 MLSRLTSRNVLLARNVATAATQERQKIKVDNPVVDLDGDEMTRIIWKEIKNKLILPYLDLDIKYYDLGLEYRDETNDQVTIDAAHAILEHSVGIKCATITPDEARIKEFNLKKMWLSPNGTIRNILGGTVFREPILCKNIPRLVPGWTQPITIGRHAFGDQYKCTDLVIPSGSTLQLLVNKPDGSK-DVHNVYDFKKSGGVGLAMYNTDESIKGFAHSCFQYALMKQWPLYLSTKNTILKKYDGRFKDIFQDIYEKKYEADFKNNKIWYEHRLIDDQVAQALKSSGGFVWACKNYDGDVQSDIVAQGYGSLGLMSSVLMCPDGKTIEAEAAHGTVTRHYREHQKGNSTSTNPIASIFAWTRGLHHRGVLDNNEALKTFSLTLEKACIDTVEEGKMTKDLSICIHGTKKGTEKGAYLITEDFLSAI 424
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Celegans
Match: idh-1 (Isocitrate dehydrogenase [NADP] [Source:UniProtKB/TrEMBL;Acc:H9G2T4])

HSP 1 Score: 568.155 bits (1463), Expect = 0.000e+0
Identity = 269/402 (66.92%), Postives = 319/402 (79.35%), Query Frame = 1 
Query:  115 VVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHG--LKNVKPEHYLNTMDFLEAIAENFESQH 1314
            +VE+ GDEMTRIIW+ IKE+LI PYV+++  ++DLG+ HRD T+DQVTID+A A LKYNV +KCATITPDE RV+EFKLKKMW SPNGTIRNILGGTVFREPII K +PRLV  W + I+IGRHAH DQYKATD+V    GKLE+ F   D + T   TVF FK   GV ++MYNTD+SI  FAH+ F+YA+ +K+PLYLSTKNTILK+YDGRFKDIF EIY  +Y+AEF    IWYEHRLIDDMVAQA+KS GGFVW CKNYDGDVQSD VAQGYGSLGLMTSVL+CPDGKT+EAEAAHGTVTRHYR HQKG+ TSTNPIASIFAW+RGL HR  LD N  L  + + +E  C++T+++G +TKDLA C+ G     V    YLNT +FL+ +AEN   + 
Sbjct:   34 IVEMQGDEMTRIIWDLIKEKLILPYVDLNVHFFDLGIEHRDATDDQVTIDAANATLKYNVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRLVNTWSKPIIIGRHAHADQYKATDFVVPGAGKLEIKFVSADGTQTIQETVFDFKGP-GVSLSMYNTDDSIRDFAHASFKYALQRKFPLYLSTKNTILKKYDGRFKDIFAEIYP-EYEAEFKAAGIWYEHRLIDDMVAQAMKSDGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLVCPDGKTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRATLDKNSALETFANNLEAVCIETMEAGFLTKDLAICVKGGNASAVTRTDYLNTFEFLDKLAENLAKKQ 433
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Celegans
Match: idh-1 (Isocitrate dehydrogenase [NADP] [Source:UniProtKB/TrEMBL;Acc:H9G2T4])

HSP 1 Score: 567.77 bits (1462), Expect = 0.000e+0
Identity = 269/402 (66.92%), Postives = 319/402 (79.35%), Query Frame = 1 
Query:  115 VVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHG--LKNVKPEHYLNTMDFLEAIAENFESQH 1314
            +VE+ GDEMTRIIW+ IKE+LI PYV+++  ++DLG+ HRD T+DQVTID+A A LKYNV +KCATITPDE RV+EFKLKKMW SPNGTIRNILGGTVFREPII K +PRLV  W + I+IGRHAH DQYKATD+V    GKLE+ F   D + T   TVF FK   GV ++MYNTD+SI  FAH+ F+YA+ +K+PLYLSTKNTILK+YDGRFKDIF EIY  +Y+AEF    IWYEHRLIDDMVAQA+KS GGFVW CKNYDGDVQSD VAQGYGSLGLMTSVL+CPDGKT+EAEAAHGTVTRHYR HQKG+ TSTNPIASIFAW+RGL HR  LD N  L  + + +E  C++T+++G +TKDLA C+ G     V    YLNT +FL+ +AEN   + 
Sbjct:   11 IVEMQGDEMTRIIWDLIKEKLILPYVDLNVHFFDLGIEHRDATDDQVTIDAANATLKYNVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRLVNTWSKPIIIGRHAHADQYKATDFVVPGAGKLEIKFVSADGTQTIQETVFDFKGP-GVSLSMYNTDDSIRDFAHASFKYALQRKFPLYLSTKNTILKKYDGRFKDIFAEIYP-EYEAEFKAAGIWYEHRLIDDMVAQAMKSDGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLVCPDGKTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRATLDKNSALETFANNLEAVCIETMEAGFLTKDLAICVKGGNASAVTRTDYLNTFEFLDKLAENLAKKQ 410
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Fly
Match: Idh (gene:FBgn0001248 transcript:FBtr0333058)

HSP 1 Score: 562.377 bits (1448), Expect = 0.000e+0
Identity = 271/433 (62.59%), Postives = 335/433 (77.37%), Query Frame = 1 
Query:   16 HNSKLFLEMLSRIS--LRLICARFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHG-LKNVKPEHYLNTMDFLEAIAENFE 1305
            H   +  E +S +S    ++C+    A +I  A PVV++ GDEMTRIIW+ IK +LI P+++++   YDLG+ +RD+T DQVTID AEAI KYNVGIKCATITPDE+RV+EF LKKMW SPNGTIRNILGGTVFRE IICK +PRLV GW++ IVIGRHAH DQYKA DYV   PGKL L +   D    D + +  FK   G+ + M+NTD+SI  FAH+ F+YA+++K PLY+STKNTILK+YDGRFKDIF+++Y++QYK E++   IWYEHRLIDDMVA A+KS GGFVW CKNYDGDVQSD VAQGYGSLGLMTSVL+CPDGKT+EAEAAHGTVTRH+R +Q+GK TSTNPIASIFAWTRGL HR KLD N+ L ++   +E+ C+DT++SG MTKDLA CI G +  V    Y  T +F+  +A+N E
Sbjct:   39 HKISMDNERMSAVSEHSSVVCSPEQMAQKIK-AGPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPIVIGRHAHADQYKAVDYVVPGPGKLTLTWKGTDGQVIDEV-INDFKG-PGIALGMFNTDDSIVDFAHASFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCIDTIESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLE 468
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Fly
Match: Idh (gene:FBgn0001248 transcript:FBtr0076671)

HSP 1 Score: 560.066 bits (1442), Expect = 0.000e+0
Identity = 270/426 (63.38%), Postives = 333/426 (78.17%), Query Frame = 1 
Query:   37 EMLSRIS--LRLICARFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHG-LKNVKPEHYLNTMDFLEAIAENFE 1305
            E +S +S    ++C+    A +I  A PVV++ GDEMTRIIW+ IK +LI P+++++   YDLG+ +RD+T DQVTID AEAI KYNVGIKCATITPDE+RV+EF LKKMW SPNGTIRNILGGTVFRE IICK +PRLV GW++ IVIGRHAH DQYKA DYV   PGKL L +   D    D + +  FK  G + + M+NTD+SI  FAH+ F+YA+++K PLY+STKNTILK+YDGRFKDIF+++Y++QYK E++   IWYEHRLIDDMVA A+KS GGFVW CKNYDGDVQSD VAQGYGSLGLMTSVL+CPDGKT+EAEAAHGTVTRH+R +Q+GK TSTNPIASIFAWTRGL HR KLD N+ L ++   +E+ C+DT++SG MTKDLA CI G +  V    Y  T +F+  +A+N E
Sbjct:    4 ERMSAVSEHSSVVCSPEQMAQKIK-AGPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPIVIGRHAHADQYKAVDYVVPGPGKLTLTWKGTDGQVIDEV-INDFKGPG-IALGMFNTDDSIVDFAHASFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCIDTIESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLE 426
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Fly
Match: Idh (gene:FBgn0001248 transcript:FBtr0076670)

HSP 1 Score: 560.066 bits (1442), Expect = 0.000e+0
Identity = 264/401 (65.84%), Postives = 321/401 (80.05%), Query Frame = 1 
Query:  106 ANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHG-LKNVKPEHYLNTMDFLEAIAENFE 1305
            A PVV++ GDEMTRIIW+ IK +LI P+++++   YDLG+ +RD+T DQVTID AEAI KYNVGIKCATITPDE+RV+EF LKKMW SPNGTIRNILGGTVFRE IICK +PRLV GW++ IVIGRHAH DQYKA DYV   PGKL L +   D    D + +  FK   G+ + M+NTD+SI  FAH+ F+YA+++K PLY+STKNTILK+YDGRFKDIF+++Y++QYK E++   IWYEHRLIDDMVA A+KS GGFVW CKNYDGDVQSD VAQGYGSLGLMTSVL+CPDGKT+EAEAAHGTVTRH+R +Q+GK TSTNPIASIFAWTRGL HR KLD N+ L ++   +E+ C+DT++SG MTKDLA CI G +  V    Y  T +F+  +A+N E
Sbjct:   60 AGPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPIVIGRHAHADQYKAVDYVVPGPGKLTLTWKGTDGQVIDEV-INDFKG-PGIALGMFNTDDSIVDFAHASFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCIDTIESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLE 458
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Fly
Match: Idh (gene:FBgn0001248 transcript:FBtr0114548)

HSP 1 Score: 559.296 bits (1440), Expect = 0.000e+0
Identity = 264/401 (65.84%), Postives = 321/401 (80.05%), Query Frame = 1 
Query:  106 ANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHG-LKNVKPEHYLNTMDFLEAIAENFE 1305
            A PVV++ GDEMTRIIW+ IK +LI P+++++   YDLG+ +RD+T DQVTID AEAI KYNVGIKCATITPDE+RV+EF LKKMW SPNGTIRNILGGTVFRE IICK +PRLV GW++ IVIGRHAH DQYKA DYV   PGKL L +   D    D + +  FK  G + + M+NTD+SI  FAH+ F+YA+++K PLY+STKNTILK+YDGRFKDIF+++Y++QYK E++   IWYEHRLIDDMVA A+KS GGFVW CKNYDGDVQSD VAQGYGSLGLMTSVL+CPDGKT+EAEAAHGTVTRH+R +Q+GK TSTNPIASIFAWTRGL HR KLD N+ L ++   +E+ C+DT++SG MTKDLA CI G +  V    Y  T +F+  +A+N E
Sbjct:   41 AGPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPIVIGRHAHADQYKAVDYVVPGPGKLTLTWKGTDGQVIDEV-INDFKGPG-IALGMFNTDDSIVDFAHASFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCIDTIESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLE 439
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Fly
Match: Idh (gene:FBgn0001248 transcript:FBtr0114549)

HSP 1 Score: 559.296 bits (1440), Expect = 0.000e+0
Identity = 264/401 (65.84%), Postives = 321/401 (80.05%), Query Frame = 1 
Query:  106 ANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHG-LKNVKPEHYLNTMDFLEAIAENFE 1305
            A PVV++ GDEMTRIIW+ IK +LI P+++++   YDLG+ +RD+T DQVTID AEAI KYNVGIKCATITPDE+RV+EF LKKMW SPNGTIRNILGGTVFRE IICK +PRLV GW++ IVIGRHAH DQYKA DYV   PGKL L +   D    D + +  FK  G + + M+NTD+SI  FAH+ F+YA+++K PLY+STKNTILK+YDGRFKDIF+++Y++QYK E++   IWYEHRLIDDMVA A+KS GGFVW CKNYDGDVQSD VAQGYGSLGLMTSVL+CPDGKT+EAEAAHGTVTRH+R +Q+GK TSTNPIASIFAWTRGL HR KLD N+ L ++   +E+ C+DT++SG MTKDLA CI G +  V    Y  T +F+  +A+N E
Sbjct:   41 AGPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPIVIGRHAHADQYKAVDYVVPGPGKLTLTWKGTDGQVIDEV-INDFKGPG-IALGMFNTDDSIVDFAHASFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCIDTIESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLE 439
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Zebrafish
Match: idh1 (isocitrate dehydrogenase (NADP(+)) 1 [Source:ZFIN;Acc:ZDB-GENE-031006-1])

HSP 1 Score: 595.89 bits (1535), Expect = 0.000e+0
Identity = 275/411 (66.91%), Postives = 333/411 (81.02%), Query Frame = 1 
Query:   73 ARFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFE 1305
            +RF  + +I  A  VVE+ GDEMTR+IWE IKE+LIFPY+ +D   YDLG+ +RD T+D+VT+++AEA+ +YNVGIKCATITPDE+RV+EFKLK+MW SPNGTIRNILGGTVFRE IICK IPRLV GW + I+IGRHAHGDQYKATD+V   PG +E+ + P +   T    V  F+  GGV + MYNTD+SI  FAHS FQ  +NK WP+YLSTKNTILK+YDGRFKDIFQEIYD++YKA+++ + IWYEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDG+T+EAEAAHGTVTRHYR HQ+GK TSTNPIASIFAWTRGL HR +LD N EL  +   +E  CV+T+++G MTKDLA CI G+  V    YLNT +FL+ +AEN +
Sbjct:    4 SRFKMSQKIK-AGSVVEMQGDEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKVTVEAAEAVRRYNVGIKCATITPDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNIPRLVPGWIKPIIIGRHAHGDQYKATDFVVPGPGTVEMTYKPKNGGETLKFVVHDFEGTGGVALGMYNTDKSIRDFAHSSFQMGLNKGWPMYLSTKNTILKKYDGRFKDIFQEIYDKEYKAKYEAMGIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGRTVEAEAAHGTVTRHYRMHQQGKETSTNPIASIFAWTRGLLHRAELDKNAELRVFAEALEVVCVETIEAGFMTKDLAICIKGMSGVTRSDYLNTFEFLDKLAENLK 413
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Zebrafish
Match: idh1 (isocitrate dehydrogenase (NADP(+)) 1 [Source:ZFIN;Acc:ZDB-GENE-031006-1])

HSP 1 Score: 595.119 bits (1533), Expect = 0.000e+0
Identity = 272/400 (68.00%), Postives = 327/400 (81.75%), Query Frame = 1 
Query:  106 ANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFE 1305
            A  VVE+ GDEMTR+IWE IKE+LIFPY+ +D   YDLG+ +RD T+D+VT+++AEA+ +YNVGIKCATITPDE+RV+EFKLK+MW SPNGTIRNILGGTVFRE IICK IPRLV GW + I+IGRHAHGDQYKATD+V   PG +E+ + P +   T    V  F+  GGV + MYNTD+SI  FAHS FQ  +NK WP+YLSTKNTILK+YDGRFKDIFQEIYD++YKA+++ + IWYEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDG+T+EAEAAHGTVTRHYR HQ+GK TSTNPIASIFAWTRGL HR +LD N EL  +   +E  CV+T+++G MTKDLA CI G+  V    YLNT +FL+ +AEN +
Sbjct:   21 AGSVVEMQGDEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKVTVEAAEAVRRYNVGIKCATITPDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNIPRLVPGWIKPIIIGRHAHGDQYKATDFVVPGPGTVEMTYKPKNGGETLKFVVHDFEGTGGVALGMYNTDKSIRDFAHSSFQMGLNKGWPMYLSTKNTILKKYDGRFKDIFQEIYDKEYKAKYEAMGIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGRTVEAEAAHGTVTRHYRMHQQGKETSTNPIASIFAWTRGLLHRAELDKNAELRVFAEALEVVCVETIEAGFMTKDLAICIKGMSGVTRSDYLNTFEFLDKLAENLK 420
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Zebrafish
Match: idh1 (isocitrate dehydrogenase (NADP(+)) 1 [Source:ZFIN;Acc:ZDB-GENE-031006-1])

HSP 1 Score: 593.964 bits (1530), Expect = 0.000e+0
Identity = 274/416 (65.87%), Postives = 334/416 (80.29%), Query Frame = 1 
Query:   58 LRLICARFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFE 1305
            LR    +++  ++   A  VVE+ GDEMTR+IWE IKE+LIFPY+ +D   YDLG+ +RD T+D+VT+++AEA+ +YNVGIKCATITPDE+RV+EFKLK+MW SPNGTIRNILGGTVFRE IICK IPRLV GW + I+IGRHAHGDQYKATD+V   PG +E+ + P +   T    V  F+  GGV + MYNTD+SI  FAHS FQ  +NK WP+YLSTKNTILK+YDGRFKDIFQEIYD++YKA+++ + IWYEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDG+T+EAEAAHGTVTRHYR HQ+GK TSTNPIASIFAWTRGL HR +LD N EL  +   +E  CV+T+++G MTKDLA CI G+  V    YLNT +FL+ +AEN +
Sbjct:    2 LRHPFYQWFKMSQKIKAGSVVEMQGDEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKVTVEAAEAVRRYNVGIKCATITPDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNIPRLVPGWIKPIIIGRHAHGDQYKATDFVVPGPGTVEMTYKPKNGGETLKFVVHDFEGTGGVALGMYNTDKSIRDFAHSSFQMGLNKGWPMYLSTKNTILKKYDGRFKDIFQEIYDKEYKAKYEAMGIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGRTVEAEAAHGTVTRHYRMHQQGKETSTNPIASIFAWTRGLLHRAELDKNAELRVFAEALEVVCVETIEAGFMTKDLAICIKGMSGVTRSDYLNTFEFLDKLAENLK 417
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Zebrafish
Match: idh1 (isocitrate dehydrogenase (NADP(+)) 1 [Source:ZFIN;Acc:ZDB-GENE-031006-1])

HSP 1 Score: 577.015 bits (1486), Expect = 0.000e+0
Identity = 269/411 (65.45%), Postives = 327/411 (79.56%), Query Frame = 1 
Query:   73 ARFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFE 1305
            +RF  + +I  A  VVE+ GDEMTR+IWE IKE+LIFPY+ +D   YDLG+ +RD T+D+VT+++AEA+ +YNVGIKCATITPDE+RV+EFKLK+MW SPNGTIRNIL      E IICK IPRLV GW + I+IGRHAHGDQYKATD+V   PG +E+ + P +   T    V  F+  GGV + MYNTD+SI  FAHS FQ  +NK WP+YLSTKNTILK+YDGRFKDIFQEIYD++YKA+++ + IWYEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDG+T+EAEAAHGTVTRHYR HQ+GK TSTNPIASIFAWTRGL HR +LD N EL  +   +E  CV+T+++G MTKDLA CI G+  V    YLNT +FL+ +AEN +
Sbjct:    4 SRFKMSQKIK-AGSVVEMQGDEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKVTVEAAEAVRRYNVGIKCATITPDEKRVEEFKLKQMWRSPNGTIRNIL------EAIICKNIPRLVPGWIKPIIIGRHAHGDQYKATDFVVPGPGTVEMTYKPKNGGETLKFVVHDFEGTGGVALGMYNTDKSIRDFAHSSFQMGLNKGWPMYLSTKNTILKKYDGRFKDIFQEIYDKEYKAKYEAMGIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGRTVEAEAAHGTVTRHYRMHQQGKETSTNPIASIFAWTRGLLHRAELDKNAELRVFAEALEVVCVETIEAGFMTKDLAICIKGMSGVTRSDYLNTFEFLDKLAENLK 407
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Zebrafish
Match: idh1 (isocitrate dehydrogenase (NADP(+)) 1 [Source:ZFIN;Acc:ZDB-GENE-031006-1])

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 268/416 (64.42%), Postives = 328/416 (78.85%), Query Frame = 1 
Query:   58 LRLICARFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFE 1305
            LR    +++  ++   A  VVE+ GDEMTR+IWE IKE+LIFPY+ +D   YDLG+ +RD T+D+VT+++AEA+ +YNVGIKCATITPDE+RV+EFKLK+MW SPNGTIRNIL      E IICK IPRLV GW + I+IGRHAHGDQYKATD+V   PG +E+ + P +   T    V  F+  GGV + MYNTD+SI  FAHS FQ  +NK WP+YLSTKNTILK+YDGRFKDIFQEIYD++YKA+++ + IWYEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDG+T+EAEAAHGTVTRHYR HQ+GK TSTNPIASIFAWTRGL HR +LD N EL  +   +E  CV+T+++G MTKDLA CI G+  V    YLNT +FL+ +AEN +
Sbjct:    2 LRHPFYQWFKMSQKIKAGSVVEMQGDEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKVTVEAAEAVRRYNVGIKCATITPDEKRVEEFKLKQMWRSPNGTIRNIL------EAIICKNIPRLVPGWIKPIIIGRHAHGDQYKATDFVVPGPGTVEMTYKPKNGGETLKFVVHDFEGTGGVALGMYNTDKSIRDFAHSSFQMGLNKGWPMYLSTKNTILKKYDGRFKDIFQEIYDKEYKAKYEAMGIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGRTVEAEAAHGTVTRHYRMHQQGKETSTNPIASIFAWTRGLLHRAELDKNAELRVFAEALEVVCVETIEAGFMTKDLAICIKGMSGVTRSDYLNTFEFLDKLAENLK 411
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Xenopus
Match: pdk4 (pyruvate dehydrogenase kinase 4 [Source:Xenbase;Acc:XB-GENE-491645])

HSP 1 Score: 669.078 bits (1725), Expect = 0.000e+0
Identity = 318/412 (77.18%), Postives = 355/412 (86.17%), Query Frame = 1 
Query:   76 RFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIH-GLKNVK-PEHYLNTMDFLEAIAENFE 1305
            R Y+  RI VANPVVE+DGDEMTRIIWE IKE+LI   V+V+ KY+DLGLP+RDQTNDQVTIDSA A LKYNV +KCATITPDE RV+EFKLKKMW SPNGTIRNILGGTVFR+PIICK IPRLV GW +AI IGRHAHGDQYKATD+V  + G  +LVF P + + T    VF F   GGVGM MYNTDESI GFAHSCFQY+I KKWPLYLSTKNTILK YDGRFKDIFQ+I+++ YK EFDKLKIWYEHRLIDDMVAQ LKS+GGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLDGN++LI +   +EK CV+TV+SG MTKDLAGCIH G+ NV+  EHY+NT DFL+AI  N +
Sbjct:   39 RNYADKRIKVANPVVEMDGDEMTRIIWEFIKEKLILSNVDVELKYFDLGLPYRDQTNDQVTIDSALATLKYNVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFRDPIICKNIPRLVPGWTQAITIGRHAHGDQYKATDFVVDQAGTFKLVFAPANGTATKEWEVFNFP-AGGVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQDIFEKHYKPEFDKLKIWYEHRLIDDMVAQVLKSTGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLINFSLTLEKVCVETVESGIMTKDLAGCIHGGMSNVRLNEHYVNTTDFLDAIKNNLD 449
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Xenopus
Match: pdk4 (pyruvate dehydrogenase kinase 4 [Source:Xenbase;Acc:XB-GENE-491645])

HSP 1 Score: 668.307 bits (1723), Expect = 0.000e+0
Identity = 319/416 (76.68%), Postives = 357/416 (85.82%), Query Frame = 1 
Query:   67 ICARF-YSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIH-GLKNVK-PEHYLNTMDFLEAIAENFE 1305
            +C R  Y+  RI VANPVVE+DGDEMTRIIWE IKE+LI   V+V+ KY+DLGLP+RDQTNDQVTIDSA A LKYNV +KCATITPDE RV+EFKLKKMW SPNGTIRNILGGTVFR+PIICK IPRLV GW +AI IGRHAHGDQYKATD+V  + G  +LVF P + + T    VF F   GGVGM MYNTDESI GFAHSCFQY+I KKWPLYLSTKNTILK YDGRFKDIFQ+I+++ YK EFDKLKIWYEHRLIDDMVAQ LKS+GGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLDGN++LI +   +EK CV+TV+SG MTKDLAGCIH G+ NV+  EHY+NT DFL+AI  N +
Sbjct:    5 VCGRMKYADKRIKVANPVVEMDGDEMTRIIWEFIKEKLILSNVDVELKYFDLGLPYRDQTNDQVTIDSALATLKYNVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFRDPIICKNIPRLVPGWTQAITIGRHAHGDQYKATDFVVDQAGTFKLVFAPANGTATKEWEVFNFP-AGGVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQDIFEKHYKPEFDKLKIWYEHRLIDDMVAQVLKSTGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLINFSLTLEKVCVETVESGIMTKDLAGCIHGGMSNVRLNEHYVNTTDFLDAIKNNLD 419
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Xenopus
Match: pdk4 (pyruvate dehydrogenase kinase 4 [Source:Xenbase;Acc:XB-GENE-491645])

HSP 1 Score: 667.922 bits (1722), Expect = 0.000e+0
Identity = 320/426 (75.12%), Postives = 359/426 (84.27%), Query Frame = 1 
Query:   43 LSRISLRLICARFYS---ATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIH-GLKNVK-PEHYLNTMDFLEAIAENFE 1305
            L ++     C+ F      TRI VANPVVE+DGDEMTRIIWE IKE+LI   V+V+ KY+DLGLP+RDQTNDQVTIDSA A LKYNV +KCATITPDE RV+EFKLKKMW SPNGTIRNILGGTVFR+PIICK IPRLV GW +AI IGRHAHGDQYKATD+V  + G  +LVF P + + T    VF F   GGVGM MYNTDESI GFAHSCFQY+I KKWPLYLSTKNTILK YDGRFKDIFQ+I+++ YK EFDKLKIWYEHRLIDDMVAQ LKS+GGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLDGN++LI +   +EK CV+TV+SG MTKDLAGCIH G+ NV+  EHY+NT DFL+AI  N +
Sbjct:    6 LRKVPFACSCSTFLDPPRTTRIKVANPVVEMDGDEMTRIIWEFIKEKLILSNVDVELKYFDLGLPYRDQTNDQVTIDSALATLKYNVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFRDPIICKNIPRLVPGWTQAITIGRHAHGDQYKATDFVVDQAGTFKLVFAPANGTATKEWEVFNFP-AGGVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQDIFEKHYKPEFDKLKIWYEHRLIDDMVAQVLKSTGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLINFSLTLEKVCVETVESGIMTKDLAGCIHGGMSNVRLNEHYVNTTDFLDAIKNNLD 430
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Xenopus
Match: pdk4 (pyruvate dehydrogenase kinase 4 [Source:Xenbase;Acc:XB-GENE-491645])

HSP 1 Score: 667.152 bits (1720), Expect = 0.000e+0
Identity = 317/411 (77.13%), Postives = 354/411 (86.13%), Query Frame = 1 
Query:   79 FYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIH-GLKNVK-PEHYLNTMDFLEAIAENFE 1305
             Y+  RI VANPVVE+DGDEMTRIIWE IKE+LI   V+V+ KY+DLGLP+RDQTNDQVTIDSA A LKYNV +KCATITPDE RV+EFKLKKMW SPNGTIRNILGGTVFR+PIICK IPRLV GW +AI IGRHAHGDQYKATD+V  + G  +LVF P + + T    VF F   GGVGM MYNTDESI GFAHSCFQY+I KKWPLYLSTKNTILK YDGRFKDIFQ+I+++ YK EFDKLKIWYEHRLIDDMVAQ LKS+GGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLDGN++LI +   +EK CV+TV+SG MTKDLAGCIH G+ NV+  EHY+NT DFL+AI  N +
Sbjct:   68 LYADKRIKVANPVVEMDGDEMTRIIWEFIKEKLILSNVDVELKYFDLGLPYRDQTNDQVTIDSALATLKYNVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFRDPIICKNIPRLVPGWTQAITIGRHAHGDQYKATDFVVDQAGTFKLVFAPANGTATKEWEVFNFP-AGGVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQDIFEKHYKPEFDKLKIWYEHRLIDDMVAQVLKSTGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLINFSLTLEKVCVETVESGIMTKDLAGCIHGGMSNVRLNEHYVNTTDFLDAIKNNLD 477
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Xenopus
Match: pdk4 (pyruvate dehydrogenase kinase 4 [Source:Xenbase;Acc:XB-GENE-491645])

HSP 1 Score: 666.381 bits (1718), Expect = 0.000e+0
Identity = 317/410 (77.32%), Postives = 354/410 (86.34%), Query Frame = 1 
Query:   82 YSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIH-GLKNVK-PEHYLNTMDFLEAIAENFE 1305
            Y+  RI VANPVVE+DGDEMTRIIWE IKE+LI   V+V+ KY+DLGLP+RDQTNDQVTIDSA A LKYNV +KCATITPDE RV+EFKLKKMW SPNGTIRNILGGTVFR+PIICK IPRLV GW +AI IGRHAHGDQYKATD+V  + G  +LVF P + + T    VF F   GGVGM MYNTDESI GFAHSCFQY+I KKWPLYLSTKNTILK YDGRFKDIFQ+I+++ YK EFDKLKIWYEHRLIDDMVAQ LKS+GGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLDGN++LI +   +EK CV+TV+SG MTKDLAGCIH G+ NV+  EHY+NT DFL+AI  N +
Sbjct:   15 YADKRIKVANPVVEMDGDEMTRIIWEFIKEKLILSNVDVELKYFDLGLPYRDQTNDQVTIDSALATLKYNVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFRDPIICKNIPRLVPGWTQAITIGRHAHGDQYKATDFVVDQAGTFKLVFAPANGTATKEWEVFNFP-AGGVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQDIFEKHYKPEFDKLKIWYEHRLIDDMVAQVLKSTGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLINFSLTLEKVCVETVESGIMTKDLAGCIHGGMSNVRLNEHYVNTTDFLDAIKNNLD 423
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Mouse
Match: Idh2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial [Source:MGI Symbol;Acc:MGI:96414])

HSP 1 Score: 670.233 bits (1728), Expect = 0.000e+0
Identity = 317/411 (77.13%), Postives = 350/411 (85.16%), Query Frame = 1 
Query:   76 RFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVK-PEHYLNTMDFLEAIAENFE 1305
            R Y+  RI V  PVVE+DGDEMTRIIW+ IKE+LI P+V+V  KY+DLGLP+RDQTNDQVTIDSA A  KY+V +KCATITPDE RV+EFKLKKMW SPNGTIRNILGGTVFREPIICK IPRLV GW + I IGRHAHGDQYKATD+V  + G  +LVFTP D S      V+ F   GGVGM MYNTDESI GFAHSCFQY+I KKWPLYLSTKNTILK YDGRFKDIFQEI+D+ YK +FDK KIWYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLDGN++LI++   +EK CV TV+SG MTKDLAGCIHGL NVK  EH+LNT DFL+ I  N +
Sbjct:   37 RHYAEKRIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPA-GGVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLD 446
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Mouse
Match: Idh1 (isocitrate dehydrogenase 1 (NADP+), soluble [Source:MGI Symbol;Acc:MGI:96413])

HSP 1 Score: 601.282 bits (1549), Expect = 0.000e+0
Identity = 278/399 (69.67%), Postives = 330/399 (82.71%), Query Frame = 1 
Query:  115 VVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFESQ 1311
            VVE+ GDEMTRIIWE IKE+LI PYV +D   YDLG+ +RD TNDQVT D+AEAI KYNVG+KCATITPDE+RV+EFKLK+MW SPNGTIRNILGGTVFRE IICK IPRLV GW + I+IGRHA+GDQY+ATD+V   PGK+E+ +TP D +   T  V  F+  GGV M MYN D+SIE FAHS FQ A++K WPLYLSTKNTILK+YDGRFKDIFQEIYD++YK++F+  KI YEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAHGTVTRHYR +QKG+ TSTNPIASIFAW+RGL HR KLD N EL  +   +E  C++T+++G MTKDLA CI GL NV+   YLNT +F++ + EN +++
Sbjct:   10 VVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFEAQKICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALEDVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAK 408
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Mouse
Match: Idh1 (isocitrate dehydrogenase 1 (NADP+), soluble [Source:MGI Symbol;Acc:MGI:96413])

HSP 1 Score: 601.282 bits (1549), Expect = 0.000e+0
Identity = 278/399 (69.67%), Postives = 330/399 (82.71%), Query Frame = 1 
Query:  115 VVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFESQ 1311
            VVE+ GDEMTRIIWE IKE+LI PYV +D   YDLG+ +RD TNDQVT D+AEAI KYNVG+KCATITPDE+RV+EFKLK+MW SPNGTIRNILGGTVFRE IICK IPRLV GW + I+IGRHA+GDQY+ATD+V   PGK+E+ +TP D +   T  V  F+  GGV M MYN D+SIE FAHS FQ A++K WPLYLSTKNTILK+YDGRFKDIFQEIYD++YK++F+  KI YEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAHGTVTRHYR +QKG+ TSTNPIASIFAW+RGL HR KLD N EL  +   +E  C++T+++G MTKDLA CI GL NV+   YLNT +F++ + EN +++
Sbjct:   10 VVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFEAQKICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALEDVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAK 408
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Mouse
Match: Idh1 (isocitrate dehydrogenase 1 (NADP+), soluble [Source:MGI Symbol;Acc:MGI:96413])

HSP 1 Score: 281.182 bits (718), Expect = 6.506e-92
Identity = 132/193 (68.39%), Postives = 155/193 (80.31%), Query Frame = 1 
Query:  115 VVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAIN 693
            VVE+ GDEMTRIIWE IKE+LI PYV +D   YDLG+ +RD TNDQVT D+AEAI KYNVG+KCATITPDE+RV+EFKLK+MW SPNGTIRNILGGTVFRE IICK IPRLV GW + I+IGRHA+GDQY+ATD+V   PGK+E+ +TP D +   T  V  F+  GGV M MYN D+SIE FAHS FQ A++
Sbjct:   10 VVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAMGMYNQDKSIEDFAHSSFQMALS 202
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Mouse
Match: Idh2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial [Source:MGI Symbol;Acc:MGI:96414])

HSP 1 Score: 284.263 bits (726), Expect = 1.010e-91
Identity = 136/191 (71.20%), Postives = 152/191 (79.58%), Query Frame = 1 
Query:   76 RFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDE 648
            R Y+  RI V  PVVE+DGDEMTRIIW+ IKE+LI P+V+V  KY+DLGLP+RDQTNDQVTIDSA A  KY+V +KCATITPDE RV+EFKLKKMW SPNGTIRNILGGTVFREPIICK IPRLV GW + I IGRHAHGDQYKATD+V  + G  +LVFTP D S      V+ F   GGVGM MYNTDE
Sbjct:   37 RHYAEKRIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPA-GGVGMGMYNTDE 226
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. UniProt/SwissProt
Match: sp|P33198|IDHP_PIG (Isocitrate dehydrogenase [NADP], mitochondrial (Fragment) OS=Sus scrofa OX=9823 GN=IDH2 PE=1 SV=1)

HSP 1 Score: 672.929 bits (1735), Expect = 0.000e+0
Identity = 317/413 (76.76%), Postives = 353/413 (85.47%), Query Frame = 1 
Query:   70 CARFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVK-PEHYLNTMDFLEAIAENFE 1305
             AR Y+  RI VA PVVE+DGDEMTRIIW+ IKE+LI P+V+V  KY+DLGLP+RDQTNDQVTIDSA A  KY+V +KCATITPDE RV+EFKLKKMW SPNGTIRNILGGTVFREPIICK IPRLV GW + I IGRHAHGDQYKATD+V  + G  ++VFTP D S      V+ F   GGVGM MYNTDESI GFAHSCFQYAI KKWPLY+STKNTILK YDGRFKDIFQEI+++ YK +FDK KIWYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLDGN++LI++   +EK CV+TV+SG MTKDLAGCIHGL NVK  EH+LNT DFL+ I  N +
Sbjct:    4 AARHYADQRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKIVFTPKDGSSAKQWEVYNFPA-GGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFDKYKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLD 415
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. UniProt/SwissProt
Match: sp|P48735|IDHP_HUMAN (Isocitrate dehydrogenase [NADP], mitochondrial OS=Homo sapiens OX=9606 GN=IDH2 PE=1 SV=2)

HSP 1 Score: 672.159 bits (1733), Expect = 0.000e+0
Identity = 316/411 (76.89%), Postives = 354/411 (86.13%), Query Frame = 1 
Query:   76 RFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVK-PEHYLNTMDFLEAIAENFE 1305
            R Y+  RI VA PVVE+DGDEMTRIIW+ IKE+LI P+V++  KY+DLGLP+RDQT+DQVTIDSA A  KY+V +KCATITPDE RV+EFKLKKMW SPNGTIRNILGGTVFREPIICK IPRLV GW + I IGRHAHGDQYKATD+VA + G  ++VFTP D S      V+ F   GGVGM MYNTDESI GFAHSCFQYAI KKWPLY+STKNTILK YDGRFKDIFQEI+D+ YK +FDK KIWYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLDGN++LI++  ++EK CV+TV+SG MTKDLAGCIHGL NVK  EH+LNT DFL+ I  N +
Sbjct:   37 RHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPA-GGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLD 446
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. UniProt/SwissProt
Match: sp|Q4R502|IDHP_MACFA (Isocitrate dehydrogenase [NADP], mitochondrial OS=Macaca fascicularis OX=9541 GN=IDH2 PE=2 SV=1)

HSP 1 Score: 671.389 bits (1731), Expect = 0.000e+0
Identity = 316/411 (76.89%), Postives = 353/411 (85.89%), Query Frame = 1 
Query:   76 RFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVK-PEHYLNTMDFLEAIAENFE 1305
            R Y+  RI VA PVVE+DGDEMTRIIW+ IKE+LI P+V++  KY+DLGLP+RDQT+DQVTIDSA A  KY+V +KCATITPDE RV+EFKLKKMW SPNGTIRNILGGTVFREPIICK IPRLV GW + I IGRHAHGDQYKATD+VA + G  ++VFTP D S      V+ F   GGVGM MYNTDESI GFAHSCFQYAI KKWPLY+STKNTILK YDGRFKDIFQEI+D+ YK +FDK KIWYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLDGN++LI++   +EK CV+TV+SG MTKDLAGCIHGL NVK  EH+LNT DFL+ I  N +
Sbjct:   37 RHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPA-GGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLD 446
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. UniProt/SwissProt
Match: sp|P54071|IDHP_MOUSE (Isocitrate dehydrogenase [NADP], mitochondrial OS=Mus musculus OX=10090 GN=Idh2 PE=1 SV=3)

HSP 1 Score: 670.233 bits (1728), Expect = 0.000e+0
Identity = 317/411 (77.13%), Postives = 350/411 (85.16%), Query Frame = 1 
Query:   76 RFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVK-PEHYLNTMDFLEAIAENFE 1305
            R Y+  RI V  PVVE+DGDEMTRIIW+ IKE+LI P+V+V  KY+DLGLP+RDQTNDQVTIDSA A  KY+V +KCATITPDE RV+EFKLKKMW SPNGTIRNILGGTVFREPIICK IPRLV GW + I IGRHAHGDQYKATD+V  + G  +LVFTP D S      V+ F   GGVGM MYNTDESI GFAHSCFQY+I KKWPLYLSTKNTILK YDGRFKDIFQEI+D+ YK +FDK KIWYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLDGN++LI++   +EK CV TV+SG MTKDLAGCIHGL NVK  EH+LNT DFL+ I  N +
Sbjct:   37 RHYAEKRIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPA-GGVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLD 446
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. UniProt/SwissProt
Match: sp|P56574|IDHP_RAT (Isocitrate dehydrogenase [NADP], mitochondrial OS=Rattus norvegicus OX=10116 GN=Idh2 PE=1 SV=2)

HSP 1 Score: 668.307 bits (1723), Expect = 0.000e+0
Identity = 316/411 (76.89%), Postives = 350/411 (85.16%), Query Frame = 1 
Query:   76 RFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVK-PEHYLNTMDFLEAIAENFE 1305
            R Y+  RI V  PVVE+DGDEMTRIIW+ IKE+LI P+V+V  KY+DLGLP+RDQTNDQVTIDSA A  KY+V +KCATITPDE RV+EFKLKKMW SPNGTIRNILGGTVFREPIICK IPRLV GW + I IGRHAHGDQYKATD+V  + G  +LVFTP D S      V+ F   GGVGM MYNTDESI GFAHSCFQY+I KKWPLYLSTKNTI+K YDGRFKDIFQEI+D+ YK +FDK KIWYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLDGN++LI++   +EK CV TV+SG MTKDLAGCIHGL NVK  EH+LNT DFL+ I  N +
Sbjct:   37 RHYAEKRIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVDRAGMFKLVFTPKDGSGAKEWEVYNFPA-GGVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTIMKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLD 446
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. TrEMBL
Match: A0A2T7PFS0 (Isocitrate dehydrogenase [NADP] OS=Pomacea canaliculata OX=400727 GN=C0Q70_07706 PE=3 SV=1)

HSP 1 Score: 736.873 bits (1901), Expect = 0.000e+0
Identity = 349/406 (85.96%), Postives = 368/406 (90.64%), Query Frame = 1 
Query:   94 RISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFESQ 1311
            RI VANPVVELDGDEMTRIIWEKIKERLIFPYV+VDCKYYDLGLP+RDQTNDQVTIDSAEAI KYNVGIKCATITPDEERVKEF LKKMWLSPNGTIRNILGGTVFREPIICKTIPRLV GW + IVIGRHAHGDQYKATD V   PG LELVFTP        L VFQFK+ GGVGMAMYNTDESI GFAH+ FQYA+ K WPLY+STKNTILKRYDGRFKDIFQEIYD+QYK +F+K  IWYEHRLIDDMVAQALKSSGGFVW CKNYDGDVQSDIVAQGYGSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASI+AWTRGLEHRGKLDGN EL ++  LMEK+CVD VDSGKMTKDLAGCI+GLKNVKPEH+L TMDFL+AI E FE +
Sbjct:   43 RIKVANPVVELDGDEMTRIIWEKIKERLIFPYVDVDCKYYDLGLPYRDQTNDQVTIDSAEAIKKYNVGIKCATITPDEERVKEFNLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVPGWTQPIVIGRHAHGDQYKATDAVYQGPGTLELVFTPASGGQQQKLQVFQFKSGGGVGMAMYNTDESITGFAHASFQYALMKNWPLYMSTKNTILKRYDGRFKDIFQEIYDKQYKPQFEKQGIWYEHRLIDDMVAQALKSSGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIYAWTRGLEHRGKLDGNNELQRFAQLMEKACVDCVDSGKMTKDLAGCIYGLKNVKPEHFLFTMDFLDAIGEEFERK 448
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BLAST of Isocitrate dehydrogenase [NADP] vs. TrEMBL
Match: V3ZNV5 (Isocitrate dehydrogenase [NADP] OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_220933 PE=3 SV=1)

HSP 1 Score: 719.153 bits (1855), Expect = 0.000e+0
Identity = 336/406 (82.76%), Postives = 371/406 (91.38%), Query Frame = 1 
Query:   94 RISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFESQ 1311
            RI V  PVVELDGDEMTRIIWEKIKE+LIFPY+++DCKYYDLGLP+RDQTNDQVTIDSAEAI KYNVGIKCATITPDEERV+EFKLKKMWLSPNGTIRNILGGTVFREPIIC+ IPRLV GW + IVIGRHA GDQY+ATD+VA  PGKLE+++TP+   P + +TV+ FK+ GGV + MYNTDESI  FAH+CFQYAI KKWPLY+STKNTILKRYDGRFKDIF+EI+ +QYK++FD+LKIWYEHRLIDDMVAQ LKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG  TSTNPIASI+AWTRGLEHRGKLDGN++L ++  LMEK+CVDTVDSGKMTKDLAGCIHGLKNV P HYLNTMDFL AI+E FE Q
Sbjct:   41 RIKVDKPVVELDGDEMTRIIWEKIKEQLIFPYLDLDCKYYDLGLPYRDQTNDQVTIDSAEAIKKYNVGIKCATITPDEERVEEFKLKKMWLSPNGTIRNILGGTVFREPIICQKIPRLVPGWTQPIVIGRHAFGDQYRATDFVAPGPGKLEMIYTPNGGQP-NKMTVYDFKDGGGVALCMYNTDESITNFAHACFQYAIMKKWPLYMSTKNTILKRYDGRFKDIFEEIFAKQYKSKFDELKIWYEHRLIDDMVAQCLKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGNQTSTNPIASIYAWTRGLEHRGKLDGNQDLQRWAQLMEKACVDTVDSGKMTKDLAGCIHGLKNVTPSHYLNTMDFLSAISEEFERQ 445
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BLAST of Isocitrate dehydrogenase [NADP] vs. TrEMBL
Match: A0A0L8H5J4 (Isocitrate dehydrogenase [NADP] OS=Octopus bimaculoides OX=37653 GN=OCBIM_22021866mg PE=3 SV=1)

HSP 1 Score: 717.613 bits (1851), Expect = 0.000e+0
Identity = 339/435 (77.93%), Postives = 375/435 (86.21%), Query Frame = 1 
Query:    7 LTIHNSKLFLEMLSRISLRLICARFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFESQ 1311
            L  H S     +++  +L +   R Y+  RI VANPVVELDGDEMTRIIWEKIKERLIFPYV VDCKY+DLGLPHRD T+DQVTIDSA AI+KYNVGIKCATITPDE RV+EF LKKMWLSPNGTIRNILGGTVFREPIICKTIPRLV GW +AI IGRHAHGDQYKATD V   PGKLE+VFTP++      +T+F FK  GGVGM MYNTD+SI  FAH+ FQYA+ KKWPLY+STKNTILKRYDGRFKDIF+EIY  +Y  +FD L IWYEHRLIDDMVAQALKSSGGFVW CKNYDGDVQSDIVAQGYGSLGLMTSVL+CPDGKTIEAEAAHGTVTRH+REHQKG PTSTNPIASIFAWTRGLEHRGKLD N+ LI++ +++E +CV+TVD+GKMTKDLAGCIHGLKNVKPEHYL TMDFLEAIAE  ++ 
Sbjct:   13 LVRHTSSSLHNLVAPATLTVQQKRNYAKKRIEVANPVVELDGDEMTRIIWEKIKERLIFPYVKVDCKYFDLGLPHRDATDDQVTIDSAHAIMKYNVGIKCATITPDEARVEEFNLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVPGWTQAITIGRHAHGDQYKATDLVIPGPGKLEMVFTPEN-GQEQRMTIFNFK-AGGVGMGMYNTDQSIRDFAHASFQYALMKKWPLYMSTKNTILKRYDGRFKDIFEEIYQAEYAKKFDDLGIWYEHRLIDDMVAQALKSSGGFVWSCKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHFREHQKGNPTSTNPIASIFAWTRGLEHRGKLDNNQNLIRFANVLEAACVETVDAGKMTKDLAGCIHGLKNVKPEHYLITMDFLEAIAETVDNH 445
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BLAST of Isocitrate dehydrogenase [NADP] vs. TrEMBL
Match: A0A0B7AME1 (Iso_dh domain-containing protein (Fragment) OS=Arion vulgaris OX=1028688 GN=ORF124277 PE=4 SV=1)

HSP 1 Score: 714.146 bits (1842), Expect = 0.000e+0
Identity = 341/415 (82.17%), Postives = 367/415 (88.43%), Query Frame = 1 
Query:   76 RFYS--ATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFESQH 1314
            R YS  + RI VANPVVELDGDEMTRIIWEKIKERLIFPYV+VDCKYYDLGLP+RDQTNDQVTIDSAEAI KYNVGIKCATITPDE+RV+EFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLV GW   IVIGRHAHGDQYKATDYV    G L+LVFTP        L VF FK  GGVG+AMYNTDESI GFAH+CFQYA+ K WPLY+STKNTILK+YDGRFKDIFQEIY+++Y  EF+K  IWYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDIVAQGYGSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG PTSTNPIASI+AWTRGL+HRGKLDGN EL ++   +EK+CVD VD GKMTKDLAGCI+GLKNVK EHYL TMDFL+AIAE ++SQ 
Sbjct:   52 RNYSRGSKRIKVANPVVELDGDEMTRIIWEKIKERLIFPYVDVDCKYYDLGLPYRDQTNDQVTIDSAEAIKKYNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVPGWTRPIVIGRHAHGDQYKATDYVIQGEGTLDLVFTPAKGGQPVKLPVFNFKKGGGVGLAMYNTDESITGFAHACFQYALMKGWPLYMSTKNTILKKYDGRFKDIFQEIYEKEYTGEFEKKGIWYEHRLIDDMVAQCLKSSGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGNPTSTNPIASIYAWTRGLDHRGKLDGNSELQQFATKLEKACVDCVDKGKMTKDLAGCIYGLKNVKTEHYLYTMDFLDAIAEEYDSQQ 466
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BLAST of Isocitrate dehydrogenase [NADP] vs. TrEMBL
Match: C3YQ59 (Isocitrate dehydrogenase [NADP] OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_115608 PE=3 SV=1)

HSP 1 Score: 712.605 bits (1838), Expect = 0.000e+0
Identity = 332/419 (79.24%), Postives = 367/419 (87.59%), Query Frame = 1 
Query:   67 ICARFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIH-GLKNVKPEHYLNTMDFLEAIAENFESQHKN 1320
            I + + S  RI VANPVVELDGDEMTRIIW+ IK++LIFPY+NVDCKYYDLGLP+RDQT+DQVTID AEAI KYNVGIKCATITPDEERV EF LK+MW SPNGTIRNILGGTVFREPIICKT+PRLV GW +AIVIGRHAHGDQYKATD+VA K GK E++FTP D S    + VF FKN GG GM MYNTDESI GFAHSC QYAINK WPLY+STKNTILKRYDGRFKDIF++IY + YK +F+  KIWYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSD+VAQGYGSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG PTSTNPIASIFAWTRGLEHRGKLDGN++L+K+C  +E++CVDTVDSGKMTKDLAGC++ G+ NVKP  YL TMDFLEAI E  + +  N
Sbjct:   41 IMSTYASGKRIEVANPVVELDGDEMTRIIWDMIKQKLIFPYINVDCKYYDLGLPYRDQTDDQVTIDCAEAIKKYNVGIKCATITPDEERVIEFNLKQMWRSPNGTIRNILGGTVFREPIICKTVPRLVPGWTQAIVIGRHAHGDQYKATDFVAEKEGKFEMMFTPADGSEPTRMEVFDFKNGGGCGMGMYNTDESITGFAHSCMQYAINKNWPLYMSTKNTILKRYDGRFKDIFEDIYQKHYKKDFESRKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDVVAQGYGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGNPTSTNPIASIFAWTRGLEHRGKLDGNQDLVKFCQTLEQACVDTVDSGKMTKDLAGCVYGGMANVKPGQYLYTMDFLEAIEEELKRKMGN 459
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Cavefish
Match: idh2 (isocitrate dehydrogenase (NADP(+)) 2 [Source:NCBI gene;Acc:103037962])

HSP 1 Score: 664.07 bits (1712), Expect = 0.000e+0
Identity = 317/423 (74.94%), Postives = 353/423 (83.45%), Query Frame = 1 
Query:   40 MLSRISLRLICARFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVK-PEHYLNTMDFLEAIAENFE 1305
            +L+  + + +  R Y+  RI VA PVVE+DGDEMTRIIWE IKE+LI   V+VD KYYDLGLP+RDQT+DQVTIDSA A  KY+V +KCATITPDE RV+EF LKKMW SPNGTIRNILGGTVFREPIICK IPRLV GW + I IGRHA GDQY+ATD+V  KPGK  + F P D S      V+ F   GG GM MYNTDESI GFAHSCFQYAI KKWPLY+STKNTILK YDGRFKDIFQEI+++ YK EFDKLKIWYEHRLIDDMVAQ LKSSG FVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLDGN +LI++   +EK CVDTV+SG MTKDLAGCIHGL NVK  EH++NT DFL+AI  N +
Sbjct:   24 VLAPATCQSLQQRNYADKRIKVAQPVVEMDGDEMTRIIWEFIKEKLILSNVDVDLKYYDLGLPYRDQTDDQVTIDSALATKKYHVAVKCATITPDEARVEEFNLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTQPITIGRHAFGDQYRATDFVINKPGKFMINFIPSDGSKGQQWEVYDFP-AGGCGMGMYNTDESITGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKNYKPEFDKLKIWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNPDLIRFSQTLEKVCVDTVESGVMTKDLAGCIHGLSNVKLNEHFVNTTDFLDAIKTNLD 445
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Cavefish
Match: idh2 (isocitrate dehydrogenase (NADP(+)) 2 [Source:NCBI gene;Acc:103037962])

HSP 1 Score: 663.685 bits (1711), Expect = 0.000e+0
Identity = 317/423 (74.94%), Postives = 353/423 (83.45%), Query Frame = 1 
Query:   40 MLSRISLRLICARFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVK-PEHYLNTMDFLEAIAENFE 1305
            +L+  + + +  R Y+  RI VA PVVE+DGDEMTRIIWE IKE+LI   V+VD KYYDLGLP+RDQT+DQVTIDSA A  KY+V +KCATITPDE RV+EF LKKMW SPNGTIRNILGGTVFREPIICK IPRLV GW + I IGRHA GDQY+ATD+V  KPGK  + F P D S      V+ F   GG GM MYNTDESI GFAHSCFQYAI KKWPLY+STKNTILK YDGRFKDIFQEI+++ YK EFDKLKIWYEHRLIDDMVAQ LKSSG FVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLDGN +LI++   +EK CVDTV+SG MTKDLAGCIHGL NVK  EH++NT DFL+AI  N +
Sbjct:   24 VLAPATCQSLQQRNYADKRIKVAQPVVEMDGDEMTRIIWEFIKEKLILSNVDVDLKYYDLGLPYRDQTDDQVTIDSALATKKYHVAVKCATITPDEARVEEFNLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTQPITIGRHAFGDQYRATDFVINKPGKFMINFIPSDGSKGQQWEVYDFP-AGGCGMGMYNTDESITGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKNYKPEFDKLKIWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNPDLIRFSQTLEKVCVDTVESGVMTKDLAGCIHGLSNVKLNEHFVNTTDFLDAIKTNLD 445
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Cavefish
Match: idh1 (isocitrate dehydrogenase (NADP(+)) 1 [Source:NCBI gene;Acc:103035389])

HSP 1 Score: 597.045 bits (1538), Expect = 0.000e+0
Identity = 272/400 (68.00%), Postives = 331/400 (82.75%), Query Frame = 1 
Query:  106 ANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFE 1305
            A  VVE+ GDEMTR+IWE IKE+LIFPY+ +D   YDLG+ +RD T+D+VT+++AEA+ +YNVGIKCATITPDE RV+EFKLK+MW SPNGTIRNILGGTVFRE IICK IPRLV GW + I+IGRHAHGDQYKATD+V   PG++E+ +TP D        V  F+  GGV M MYNTD+SI  FAHS FQ A++K  PL+LSTKNTILK+YDGRFKDIFQEIYD++YKA+F+  KI+YEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDG+T+EAEAAHGTVTRHYR+HQ+GK TSTNPIASIFAWTRGL HR +LD N+EL  +   +E  C++T+++G MTKDLA CI G+ +V+   YLNT +FL+ +A+N +
Sbjct:    7 AGSVVEMQGDEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDRVTVEAAEAVRRYNVGIKCATITPDENRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNIPRLVPGWVKPIIIGRHAHGDQYKATDFVVPGPGRVEMTYTPKDGGQALKFVVHDFEGTGGVAMGMYNTDQSIRDFAHSSFQMALSKVCPLFLSTKNTILKKYDGRFKDIFQEIYDKEYKAQFEAKKIYYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGRTVEAEAAHGTVTRHYRQHQQGKETSTNPIASIFAWTRGLLHRAQLDKNRELRVFAEALEAVCIETIEAGFMTKDLAICIKGMADVQRSDYLNTFEFLDKLADNLK 406
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Sea Lamprey
Match: idh1 (isocitrate dehydrogenase (NADP(+)) 1 [Source:ZFIN;Acc:ZDB-GENE-031006-1])

HSP 1 Score: 583.178 bits (1502), Expect = 0.000e+0
Identity = 272/402 (67.66%), Postives = 323/402 (80.35%), Query Frame = 1 
Query:  106 ANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPI--ASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFE 1305
            A PVVE+ GDEMTR+IW+ IKE+LI PY+ +D   YDLG+ +RD T DQVT+D+AEAI +YNVGIKCATITPDE+RV+EF LK MW SPNGTIRNILGGTVFRE IIC  IPRLV GW + IVIGRHA+GDQYKATD+V   PGK+++ FTP +     T TV +FK+ GGV M M+NTD SI  FA S  Q  ++K WPLYLSTKNTILK+YDGRFKDIFQ+IY++ YKA+++   IWYEHRLIDDMVA A+KS GGFVW CKNYDGDVQSD +AQGYGSLG+MTSVL+CPDGKT+EAEAAHGTVTRHYR +Q+GK TSTNPI  AS+FAWTRGL HR KLD N EL  +C  +E  CV+T+++G MTKDLA CI GL NVK   YL T  F++ +A+N +
Sbjct:   21 AGPVVEMQGDEMTRVIWDLIKEKLILPYIQMDLHTYDLGMENRDATGDQVTVDAAEAIKRYNVGIKCATITPDEKRVEEFNLKTMWKSPNGTIRNILGGTVFREAIICSNIPRLVTGWVKPIVIGRHAYGDQYKATDFVVPGPGKVDITFTPKNGGVPVTYTVHEFKDGGGVTMGMFNTDASIADFARSSLQMGLDKGWPLYLSTKNTILKKYDGRFKDIFQDIYEKDYKAKYEAKNIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSIAQGYGSLGMMTSVLLCPDGKTVEAEAAHGTVTRHYRMYQQGKETSTNPIDLASVFAWTRGLAHRAKLDNNVELTHFCSALEAVCVETIEAGFMTKDLAACIKGLPNVKQGDYLETYAFMDKLADNLK 422
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Sea Lamprey
Match: idh3a (isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha [Source:ZFIN;Acc:ZDB-GENE-040426-1007])

HSP 1 Score: 47.7506 bits (112), Expect = 4.446e-6
Identity = 53/197 (26.90%), Postives = 83/197 (42.13%), Query Frame = 1 
Query:  640 TDESIEGFAHSCFQYA-INKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGF-VWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGK-MTKDLAG 1221
            TD +    A   F+YA  NK+  +    K  I++  DG F    +E+ +     EF ++        +D +    ++    F V    N  GD+ SD+ A   G LG+  S  +   G  I  E+ HGT          GK  + NP A + +    L H        +L ++   +E +C DT+  GK +T DL G
Sbjct:  159 TDTASRRIAEYAFEYARANKRSTVTAVHKANIMRMSDGLFLRKCREVAENYRDIEFTEM-------FLDTVCLNMVQDPTKFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGTGGVAI-FESVHGTA-----PDIAGKDLA-NPTALLLSAVLMLRH-------MQLQEFARRIEAACFDTIRDGKVVTGDLGG 334
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Yeast
Match: IDP1 (Mitochondrial NADP-specific isocitrate dehydrogenase; catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes [Source:SGD;Acc:S000002224])

HSP 1 Score: 550.821 bits (1418), Expect = 0.000e+0
Identity = 272/431 (63.11%), Postives = 334/431 (77.49%), Query Frame = 1 
Query:   43 LSRISLRLIC-ARFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTD--TLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDS-GKMTKDLA-GCIHGLKNVKPEHYLNTMDFLEAIAENFESQHKN 1320
            +S +S RL   +R  + ++I V  PVVELDGDEMTRIIW+KIK++LI PY++VD KYYDL +  RD T+D++T D+AEAI KY VGIKCATITPDE RVKEF L KMW SPNGTIRNILGGTVFREPI+   IPRLV  W++ I+IGRHAHGDQYKATD +   PG LELV+ P D +     TL V+ +K   GV MAMYNTDESIEGFAHS F+ AI+KK  L+LSTKNTILK+YDGRFKDIFQE+Y+ QYK++F++L I YEHRLIDDMVAQ +KS GGF+   KNYDGDVQSDIVAQG+GSLGLMTS+L+ PDGKT E+EAAHGTVTRHYR++QKG+ TSTN IASIFAW+RGL  RG+LD    L K+ +++E + ++TV   G MTKDLA  C     N +   Y+ T +FL+A+ +  + + K+
Sbjct:    1 MSMLSRRLFSTSRLAAFSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKG-SGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALAC----GNNERSAYVTTEEFLDAVEKRLQKEIKS 426
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Yeast
Match: IDP2 (Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication [Source:SGD;Acc:S000004164])

HSP 1 Score: 531.946 bits (1369), Expect = 0.000e+0
Identity = 251/408 (61.52%), Postives = 313/408 (76.72%), Query Frame = 1 
Query:   91 TRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTV-DSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFESQ 1311
            T+I VANP+VE+DGDE TRIIW  I+++L+ PY++VD KYYDL + +RDQTNDQVT+DSA A LKY V +KCATITPDE RV+EF LKKMW SPNGTIRNILGGTVFREPII   IPRLV  W++ I+IGRHA GDQYKATD +  + G+L LV+     +    L VF +   GGV M MYNT +SIEGFA + F+ AI +K PLY +TKNTILK+YDG+FKD+F+ +Y R YK +F+ L IWYEHRLIDDMVAQ LKS GG++   KNYDGDV+SDIVAQG+GSLGLMTSVL+ PDGKT E+EAAHGTVTRH+R+HQ+GK TSTN IASIFAWTRG+  RGKLD   +++K+  ++E + V+TV + G MTKDLA     L   +   Y+ T +F++A+    + +
Sbjct:    2 TKIKVANPIVEMDGDEQTRIIWHLIRDKLVLPYLDVDLKYYDLSVEYRDQTNDQVTVDSATATLKYGVAVKCATITPDEARVEEFHLKKMWKSPNGTIRNILGGTVFREPIIIPRIPRLVPQWEKPIIIGRHAFGDQYKATDVIVPEEGELRLVYKSKSGTHDVDLKVFDYPEHGGVAMMMYNTTDSIEGFAKASFELAIERKLPLYSTTKNTILKKYDGKFKDVFEAMYARSYKEKFESLGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLITPDGKTFESEAAHGTVTRHFRQHQQGKETSTNSIASIFAWTRGIIQRGKLDNTPDVVKFGQILESATVNTVQEDGIMTKDLALI---LGKSERSAYVTTEEFIDAVESRLKKE 406
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Yeast
Match: IDP3 (Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication [Source:SGD;Acc:S000004954])

HSP 1 Score: 525.013 bits (1351), Expect = 0.000e+0
Identity = 247/407 (60.69%), Postives = 312/407 (76.66%), Query Frame = 1 
Query:   91 TRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVD-SGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFES 1308
            ++I V +P+VE+DGDE TR+IW+ IKE+LI PY++VD KYYDL +  RD+TNDQVT DS+ A LKY V +KCATITPDE R+KEF LK+MW SPNGTIRNILGGTVFREPII   IPRLV  W++ I+IGRHA GDQY+ATD    K GKL L F+ DD      L V++F   GG+ MAM+NT++SI+GFA + F+ A+ +K PL+ +TKNTILK YD +FK IF  ++D++YK +F  LKI YEHRLIDDMVAQ LKS GGF+   KNYDGDVQSDIVAQG+GSLGLMTS+L+ PDGKT E+EAAHGTVTRH+R+HQ+G+ TSTN IASIFAWTR +  RGKLD   ++IK+ +L+EK+ +DTV   GKMTKDLA     L       Y+ T +F++ +A+  ++
Sbjct:    2 SKIKVVHPIVEMDGDEQTRVIWKLIKEKLILPYLDVDLKYYDLSIQERDRTNDQVTKDSSYATLKYGVAVKCATITPDEARMKEFNLKEMWKSPNGTIRNILGGTVFREPIIIPKIPRLVPHWEKPIIIGRHAFGDQYRATDIKIKKAGKLRLQFSSDDGKENIDLKVYEFPKSGGIAMAMFNTNDSIKGFAKASFELALKRKLPLFFTTKNTILKNYDNQFKQIFDNLFDKEYKEKFQALKITYEHRLIDDMVAQMLKSKGGFIIAMKNYDGDVQSDIVAQGFGSLGLMTSILITPDGKTFESEAAHGTVTRHFRKHQRGEETSTNSIASIFAWTRAIIQRGKLDNTDDVIKFGNLLEKATLDTVQVGGKMTKDLALM---LGKTNRSSYVTTEEFIDEVAKRLQN 405
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Yeast
Match: LYS12 (Homo-isocitrate dehydrogenase; an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate [Source:SGD;Acc:S000001356])

HSP 1 Score: 51.2174 bits (121), Expect = 2.368e-7
Identity = 46/166 (27.71%), Postives = 82/166 (49.40%), Query Frame = 1 
Query:  706 LYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGF-VWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHL-MEKSCVDTVDSG 1197
            L ++ K+ +L + DG F++I +E+Y+   K ++ ++K  Y  +++D MV +  +    F V    N  GD+ SD  A   GSLG++ S  + P+   +  E  HG+          GK  + NPIA+I +    LE  G  +  +++ K     + +  + T D G
Sbjct:  201 LTVTHKSNVLSQSDGLFREICKEVYESN-KDKYGQIK--YNEQIVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPE--IVIGEPCHGSA-----PDIAGKGIA-NPIATIRSTALMLEFLGHNEAAQDIYKAVDANLREGSIKTPDLG 355
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Nematostella
Match: EDO41840 (Isocitrate dehydrogenase [NADP] [Source:UniProtKB/TrEMBL;Acc:A7S378])

HSP 1 Score: 604.749 bits (1558), Expect = 0.000e+0
Identity = 281/399 (70.43%), Postives = 333/399 (83.46%), Query Frame = 1 
Query:  106 ANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENF 1302
            A PVVE+ GDEMTRIIWE IKE+LIFPYV+++ K YDL + +RD TNDQVTID+A AI + +VGIKCATITPDE+RV+EFKLKKMW SPNGTIRNILGGTVFRE IICK IPRLV  W + I+IGRHAH DQYKATD+V   PGK+E+V++P D       TV +FK+ GGV M M+NTD SI  FAHS FQYA++KK+PLY+STKNTILK+YDGRFKDIFQEIY+++YK++F++  IWYEHRLIDDMVA ALK+ GGF+W CKNYDGDVQSD VAQG+GSLG+MTSVL+CPDGKT+E+EAAHGTVTRHYR HQ+GK TSTNP+ASIFAWTRGL HR KLD N  L+ YC  +E  C++T++SG MTKDLAGCI G+ NV    YLNT +FL+ IAEN 
Sbjct:    6 AGPVVEMQGDEMTRIIWELIKEKLIFPYVDMELKSYDLSIENRDATNDQVTIDAAAAIKQCHVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVSPWTKPIIIGRHAHADQYKATDFVVPGPGKVEIVYSPADGGEPIKYTVNEFKDGGGVTMGMFNTDVSIRAFAHSSFQYALDKKYPLYMSTKNTILKKYDGRFKDIFQEIYEQEYKSKFEESNIWYEHRLIDDMVAFALKTEGGFIWACKNYDGDVQSDSVAQGFGSLGMMTSVLVCPDGKTVESEAAHGTVTRHYRMHQQGKETSTNPVASIFAWTRGLMHRAKLDDNAALLDYCKNLEAVCIETIESGAMTKDLAGCIKGISNVTRPDYLNTFEFLDKIAENL 404
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Nematostella
Match: EDO42142 (Isocitrate dehydrogenase [NADP] [Source:UniProtKB/TrEMBL;Acc:A7S2F7])

HSP 1 Score: 601.668 bits (1550), Expect = 0.000e+0
Identity = 279/389 (71.72%), Postives = 328/389 (84.32%), Query Frame = 1 
Query:  139 MTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFE 1305
            MTRIIW+ IK +LI PY+++D KY+DLGL HRD TND+VT+++AEAI K++VGIKCATITPDE RV+EFKLKKMW SPNGTIRNILGGTVFR PIICKT+PRLV GW++ IVIGRHA GDQY+A D+    PG  E+ FTP+      T  VF+F   GGV M MYNTDE+I  FAHSC QYAI+K+ PLY+STKNTILK+YDGRFKDIFQ+IY+R+Y+++F +L IWYEHRLIDDMVA ALKS GGFVW  KNYDGDVQSD +AQG+GSLGLMTSVL+CPDGKTIE+EAAHGTVTRHYREHQKG  TSTNPIASIFAWT+GL HR KLDGN EL K+C  +EK+CVDTVD GKMTKDLA CI+GL NVK + YL+T+++ +A+ EN E
Sbjct:    1 MTRIIWQMIKNKLISPYLDLDIKYFDLGLEHRDATNDKVTVEAAEAIRKHHVGIKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFRAPIICKTVPRLVPGWEKPIVIGRHAFGDQYRARDFAVNGPGSFEISFTPESGGKL-TTEVFEFTGTGGVMMGMYNTDEAIRDFAHSCMQYAIHKQVPLYMSTKNTILKKYDGRFKDIFQDIYEREYESQFKELGIWYEHRLIDDMVAYALKSEGGFVWAAKNYDGDVQSDTLAQGFGSLGLMTSVLVCPDGKTIESEAAHGTVTRHYREHQKGNETSTNPIASIFAWTQGLSHRAKLDGNPELKKFCKALEKACVDTVDQGKMTKDLAACIYGLANVKRDQYLSTVEYFDAVVENLE 388
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Medaka
Match: idh2 (isocitrate dehydrogenase [NADP], mitochondrial [Source:NCBI gene;Acc:101171328])

HSP 1 Score: 668.692 bits (1724), Expect = 0.000e+0
Identity = 316/411 (76.89%), Postives = 351/411 (85.40%), Query Frame = 1 
Query:   76 RFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVK-PEHYLNTMDFLEAIAENFE 1305
            R Y+  RI VA PVVE+DGDEMTRIIWE IKE+LI   V+V+ KYYDLGLP+RDQT+DQVTIDSA A LKY+V +KCATITPDE RV+EF LKKMW SPNGTIRNILGGTVFREPIICK IPRLV GW + I IGRHA GDQY+ATD+V  +PGK +++F+P D S      VF F   GG GM MYNTDESI GFAHSCFQYAI KKWPLY+STKNTILK YDGRFKDIFQ+I+++ YK EFDKLKIWYEHRLIDDMVAQ LKSSG FVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLDGN +LIK+   +E+ CV+TV+SG MTKDLAGCIHGL NVK  EHY+NT DFL+AI  N E
Sbjct:   92 RNYADRRIKVAQPVVEMDGDEMTRIIWEFIKEKLILSNVDVELKYYDLGLPYRDQTDDQVTIDSALATLKYHVAVKCATITPDEARVEEFSLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTQPITIGRHAFGDQYRATDFVVDQPGKFKMIFSPSDGSTPKEWEVFDFPA-GGCGMGMYNTDESITGFAHSCFQYAIAKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKNYKPEFDKLKIWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLICPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNPDLIKFAQTLERVCVETVESGTMTKDLAGCIHGLSNVKLNEHYVNTTDFLDAIKTNLE 501
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Medaka
Match: ENSORLT00000015782.2 (isocitrate dehydrogenase [NADP], mitochondrial [Source:NCBI gene;Acc:101166704])

HSP 1 Score: 655.21 bits (1689), Expect = 0.000e+0
Identity = 308/411 (74.94%), Postives = 349/411 (84.91%), Query Frame = 1 
Query:   76 RFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVK-PEHYLNTMDFLEAIAENFE 1305
            R Y+  RI V  PVVE+D DEMTRIIWE IK++LI P V+V+ KY+DLGLP+RDQTNDQVTID+A A  KYNV +KCATITPDE RV+E+KLK MW SPNGTIRNILGGTVFREPI+CK IPRLV GW   I IGRHA GDQY+ATD+V  KPGK ++VF+P D S      V+ F   GG GM MYNTDESI GFAHSCFQYAI K+WPLY+STKNTILK YDGRFKDIFQ+I+++ YK EFDKLKIWYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRH+REHQ+GKPTSTNPIASIFAWTRGLEHRGKLDGN +LIK+   +EK CV+TV++G MTKDLAGCIHGL N K  EHY+NT+DF++AI  N +
Sbjct:   38 RNYATKRIKVDQPVVEMDRDEMTRIIWEFIKDKLILPNVDVELKYFDLGLPYRDQTNDQVTIDAALATKKYNVAVKCATITPDEARVEEYKLKNMWKSPNGTIRNILGGTVFREPILCKNIPRLVPGWTLPITIGRHAFGDQYRATDFVVEKPGKFKMVFSPADGSKQQEWEVYNF-TAGGCGMGMYNTDESISGFAHSCFQYAIQKRWPLYMSTKNTILKAYDGRFKDIFQDIFEKNYKPEFDKLKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHFREHQRGKPTSTNPIASIFAWTRGLEHRGKLDGNPDLIKFSQTLEKVCVETVENGVMTKDLAGCIHGLANCKLNEHYVNTLDFMDAIRTNLD 447
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BLAST of Isocitrate dehydrogenase [NADP] vs. Planmine SMEST
Match: SMESG000049154.1 (SMESG000049154.1)

HSP 1 Score: 895.96 bits (2314), Expect = 0.000e+0
Identity = 427/427 (100.00%), Postives = 427/427 (100.00%), Query Frame = 1 
Query:   40 MLSRISLRLICARFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFESQHKN 1320
            MLSRISLRLICARFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFESQHKN
Sbjct:    1 MLSRISLRLICARFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENFESQHKN 427
[Close]
BLAST of Isocitrate dehydrogenase [NADP] vs. Planmine SMEST
Match: SMESG000035181.1 (SMESG000035181.1)

HSP 1 Score: 562.377 bits (1448), Expect = 0.000e+0
Identity = 261/398 (65.58%), Postives = 323/398 (81.16%), Query Frame = 1 
Query:  112 PVVELDGDEMTRIIWEKIKERLIFPYVNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVKEFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHAHGDQYKATDYVATKPGKLELVF-TPDDKSPTDTLTVFQFKNRGGVGMAMYNTDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLKNVKPEHYLNTMDFLEAIAENF 1302
            P+VE+ GDEMTRIIW+ IKE+LI P++  +   +DL + +RD+T+DQ+T++ A AI  Y+VGIKCATITPDE R++EFKLKKM+ SPNGTIRNILGGTVFRE IICK IPRLV GW ++I+IGRHAHGDQYKATD+V    G+L + + + D K  +    V+ F+  GGV MAMYNTD+SI  FAHS FQ+A++K W LYLSTKNTILK+YDGRFKDIFQ++Y+  YK +F+   IWYEHRLIDDMVA A+KS GGFVW CKNYDGDVQSD +AQG+GSLG+MTSVL+CPDGKT+EAEAAHGTVTRHYR HQKG  TSTNPIASIFAWTRGL HR KLD N +L  +C ++EK C++T++SGKMTKDLA CI G+ +V+   +LNT +F+E ++ N 
Sbjct:    7 PIVEIQGDEMTRIIWDLIKEKLILPFIEPEIHLFDLSIQNRDKTDDQITVECANAIKLYSVGIKCATITPDENRMEEFKLKKMYRSPNGTIRNILGGTVFREAIICKNIPRLVPGWNKSIIIGRHAHGDQYKATDFVVPGAGELTISWKSADSKIESIFYKVYNFEESGGVAMAMYNTDKSIFDFAHSSFQFALDKGWVLYLSTKNTILKKYDGRFKDIFQQVYNDHYKDQFEAKNIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSIAQGFGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRIHQKGGETSTNPIASIFAWTRGLAHRAKLDENVKLEHFCKVLEKVCIETIESGKMTKDLAICIKGMNDVQRGDFLNTFEFIELLSVNL 404
The following BLAST results are available for this feature:
BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
IDH20.000e+076.89isocitrate dehydrogenase (NADP(+)) 2 [Source:HGNC ... [more]
IDH20.000e+077.47isocitrate dehydrogenase (NADP(+)) 2 [Source:HGNC ... [more]
IDH10.000e+070.78isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC ... [more]
IDH10.000e+070.78isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC ... [more]
IDH10.000e+070.78isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC ... [more]
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
idh-20.000e+071.06Isocitrate dehydrogenase [NADP] [Source:UniProtKB... [more]
idh-20.000e+071.06Isocitrate dehydrogenase [NADP] [Source:UniProtKB... [more]
idh-20.000e+071.06Isocitrate dehydrogenase [NADP] [Source:UniProtKB... [more]
idh-10.000e+066.92Isocitrate dehydrogenase [NADP] [Source:UniProtKB... [more]
idh-10.000e+066.92Isocitrate dehydrogenase [NADP] [Source:UniProtKB... [more]
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Idh0.000e+062.59gene:FBgn0001248 transcript:FBtr0333058[more]
Idh0.000e+063.38gene:FBgn0001248 transcript:FBtr0076671[more]
Idh0.000e+065.84gene:FBgn0001248 transcript:FBtr0076670[more]
Idh0.000e+065.84gene:FBgn0001248 transcript:FBtr0114548[more]
Idh0.000e+065.84gene:FBgn0001248 transcript:FBtr0114549[more]
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
idh10.000e+066.91isocitrate dehydrogenase (NADP(+)) 1 [Source:ZFIN;... [more]
idh10.000e+068.00isocitrate dehydrogenase (NADP(+)) 1 [Source:ZFIN;... [more]
idh10.000e+065.87isocitrate dehydrogenase (NADP(+)) 1 [Source:ZFIN;... [more]
idh10.000e+065.45isocitrate dehydrogenase (NADP(+)) 1 [Source:ZFIN;... [more]
idh10.000e+064.42isocitrate dehydrogenase (NADP(+)) 1 [Source:ZFIN;... [more]
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pdk40.000e+077.18pyruvate dehydrogenase kinase 4 [Source:Xenbase;Ac... [more]
pdk40.000e+076.68pyruvate dehydrogenase kinase 4 [Source:Xenbase;Ac... [more]
pdk40.000e+075.12pyruvate dehydrogenase kinase 4 [Source:Xenbase;Ac... [more]
pdk40.000e+077.13pyruvate dehydrogenase kinase 4 [Source:Xenbase;Ac... [more]
pdk40.000e+077.32pyruvate dehydrogenase kinase 4 [Source:Xenbase;Ac... [more]
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Idh20.000e+077.13isocitrate dehydrogenase 2 (NADP+), mitochondrial ... [more]
Idh10.000e+069.67isocitrate dehydrogenase 1 (NADP+), soluble [Sourc... [more]
Idh10.000e+069.67isocitrate dehydrogenase 1 (NADP+), soluble [Sourc... [more]
Idh16.506e-9268.39isocitrate dehydrogenase 1 (NADP+), soluble [Sourc... [more]
Idh21.010e-9171.20isocitrate dehydrogenase 2 (NADP+), mitochondrial ... [more]
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BLAST of Isocitrate dehydrogenase [NADP] vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P33198|IDHP_PIG0.000e+076.76Isocitrate dehydrogenase [NADP], mitochondrial (Fr... [more]
sp|P48735|IDHP_HUMAN0.000e+076.89Isocitrate dehydrogenase [NADP], mitochondrial OS=... [more]
sp|Q4R502|IDHP_MACFA0.000e+076.89Isocitrate dehydrogenase [NADP], mitochondrial OS=... [more]
sp|P54071|IDHP_MOUSE0.000e+077.13Isocitrate dehydrogenase [NADP], mitochondrial OS=... [more]
sp|P56574|IDHP_RAT0.000e+076.89Isocitrate dehydrogenase [NADP], mitochondrial OS=... [more]
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BLAST of Isocitrate dehydrogenase [NADP] vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2T7PFS00.000e+085.96Isocitrate dehydrogenase [NADP] OS=Pomacea canalic... [more]
V3ZNV50.000e+082.76Isocitrate dehydrogenase [NADP] OS=Lottia gigantea... [more]
A0A0L8H5J40.000e+077.93Isocitrate dehydrogenase [NADP] OS=Octopus bimacul... [more]
A0A0B7AME10.000e+082.17Iso_dh domain-containing protein (Fragment) OS=Ari... [more]
C3YQ590.000e+079.24Isocitrate dehydrogenase [NADP] OS=Branchiostoma f... [more]
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
idh20.000e+074.94isocitrate dehydrogenase (NADP(+)) 2 [Source:NCBI ... [more]
idh20.000e+074.94isocitrate dehydrogenase (NADP(+)) 2 [Source:NCBI ... [more]
idh10.000e+068.00isocitrate dehydrogenase (NADP(+)) 1 [Source:NCBI ... [more]
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
idh10.000e+067.66isocitrate dehydrogenase (NADP(+)) 1 [Source:ZFIN;... [more]
idh3a4.446e-626.90isocitrate dehydrogenase (NAD(+)) 3 catalytic subu... [more]
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 4
Match NameE-valueIdentityDescription
IDP10.000e+063.11Mitochondrial NADP-specific isocitrate dehydrogena... [more]
IDP20.000e+061.52Cytosolic NADP-specific isocitrate dehydrogenase; ... [more]
IDP30.000e+060.69Peroxisomal NADP-dependent isocitrate dehydrogenas... [more]
LYS122.368e-727.71Homo-isocitrate dehydrogenase; an NAD-linked mitoc... [more]
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO418400.000e+070.43Isocitrate dehydrogenase [NADP] [Source:UniProtKB... [more]
EDO421420.000e+071.72Isocitrate dehydrogenase [NADP] [Source:UniProtKB... [more]
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BLAST of Isocitrate dehydrogenase [NADP] vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
idh20.000e+076.89isocitrate dehydrogenase [NADP], mitochondrial [So... [more]
ENSORLT00000015782.20.000e+074.94isocitrate dehydrogenase [NADP], mitochondrial [So... [more]
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BLAST of Isocitrate dehydrogenase [NADP] vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000049154.10.000e+0100.00SMESG000049154.1[more]
SMESG000035181.10.000e+065.58SMESG000035181.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30024309 ID=SMED30024309|Name=Isocitrate dehydrogenase [NADP]|organism=Schmidtea mediterranea sexual|type=transcript|length=1665bp
TTTTAATTAACAATTCACAATTCAAAATTATTTTTGGAAATGTTGTCTAG
AATAAGTTTAAGGCTTATCTGTGCCCGATTTTACTCTGCCACAAGGATTT
CAGTTGCAAATCCAGTAGTAGAATTAGATGGGGATGAAATGACTAGAATC
ATTTGGGAAAAGATTAAAGAAAGACTTATTTTCCCATATGTGAATGTTGA
TTGCAAATACTACGATCTCGGATTACCTCATCGGGATCAAACAAATGACC
AAGTAACAATTGACAGCGCAGAAGCCATATTGAAATATAATGTCGGTATA
AAATGCGCCACAATAACCCCAGACGAGGAACGTGTCAAAGAGTTCAAACT
AAAAAAAATGTGGTTATCTCCTAATGGAACAATTAGAAACATTCTTGGTG
GAACAGTTTTCCGGGAGCCGATTATTTGCAAAACAATTCCCCGATTAGTT
GAAGGTTGGAAAGAAGCAATTGTCATTGGCCGTCATGCTCACGGCGATCA
GTACAAGGCCACAGATTACGTTGCCACAAAGCCGGGTAAATTGGAACTTG
TGTTCACACCGGATGACAAATCGCCAACGGACACACTGACAGTGTTCCAA
TTCAAAAATCGTGGCGGTGTCGGAATGGCAATGTACAACACCGATGAAAG
CATCGAAGGATTTGCCCACAGCTGTTTTCAGTACGCTATCAACAAGAAAT
GGCCGCTTTACCTGAGCACTAAGAATACAATTCTCAAACGTTATGATGGC
CGGTTTAAGGATATTTTCCAGGAGATTTATGACAGGCAATACAAAGCGGA
ATTCGACAAGCTGAAAATCTGGTACGAGCACCGATTAATCGATGATATGG
TTGCACAGGCCCTGAAATCGTCGGGAGGATTTGTGTGGGGTTGCAAGAAT
TACGACGGCGATGTACAAAGTGATATTGTTGCTCAGGGCTACGGCTCGCT
GGGACTGATGACCTCAGTCCTGATGTGCCCCGACGGCAAGACCATTGAGG
CAGAGGCAGCTCATGGAACCGTGACGCGACATTACAGGGAGCACCAGAAA
GGCAAGCCAACTAGTACCAATCCTATTGCCAGTATCTTTGCATGGACTCG
AGGGCTGGAGCACCGCGGCAAACTTGATGGCAACAAGGAATTGATTAAGT
ATTGCCATCTGATGGAGAAATCATGTGTCGACACTGTCGACAGCGGCAAG
ATGACAAAGGATCTCGCCGGGTGCATCCACGGCCTCAAGAACGTCAAGCC
AGAGCACTATCTCAACACAATGGATTTCCTAGAGGCTATTGCTGAGAATT
TCGAGAGTCAACACAAGAATTAAAACTGCCGTATTTCTGGTTACTTGCCA
TATTTATTTATAGGATTTTGTAATAAATTGACTAACTTTTCTGATTGGTT
GCGCTGAGTGTTGGATGTGATTGGTTAATGATTGTAATGATAATATTAAT
GGGTAATTGCTCGACATCGGGGCCTGCACCCCGAACGAGATAGTGCTGCT
GCAAGGAACAATGATTAATTACAATTTGTGCATATCTTATTGGATATCAG
GTGAATTTGAATTACATGTATAAATTAGTAACCATGCATATGAAATAAGT
AGTAGAATAACAGATCATGTTTTGTAATTGCTTTTAACGTTTTAATTAAA
AAATATCTTCAGTGG
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protein sequence of SMED30024309-orf-1

>SMED30024309-orf-1 ID=SMED30024309-orf-1|Name=SMED30024309-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=428bp
MLSRISLRLICARFYSATRISVANPVVELDGDEMTRIIWEKIKERLIFPY
VNVDCKYYDLGLPHRDQTNDQVTIDSAEAILKYNVGIKCATITPDEERVK
EFKLKKMWLSPNGTIRNILGGTVFREPIICKTIPRLVEGWKEAIVIGRHA
HGDQYKATDYVATKPGKLELVFTPDDKSPTDTLTVFQFKNRGGVGMAMYN
TDESIEGFAHSCFQYAINKKWPLYLSTKNTILKRYDGRFKDIFQEIYDRQ
YKAEFDKLKIWYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQG
YGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTNPIASIF
AWTRGLEHRGKLDGNKELIKYCHLMEKSCVDTVDSGKMTKDLAGCIHGLK
NVKPEHYLNTMDFLEAIAENFESQHKN*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000028Category 2 cell
PLANA:0000034epidermis
PLANA:0000429neoblast
Vocabulary: INTERPRO
TermDefinition
IPR024084IsoPropMal-DH-like_dom
IPR004790Isocitrate_DH_NADP
IPR019818IsoCit/isopropylmalate_DH_CS
Vocabulary: biological process
TermDefinition
GO:0055114oxidation-reduction process
GO:0006102isocitrate metabolic process
GO:0006099tricarboxylic acid cycle
Vocabulary: molecular function
TermDefinition
GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0004450isocitrate dehydrogenase (NADP+) activity
GO:0051287NAD binding
GO:0000287magnesium ion binding
GO:0016491oxidoreductase activity
GO:0046872metal ion binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR024084Isopropylmalate dehydrogenase-like domainSMARTSM01329Iso_dh_2coord: 25..417
e-value: 1.1E-135
score: 466.7
IPR024084Isopropylmalate dehydrogenase-like domainPFAMPF00180Iso_dhcoord: 22..417
e-value: 3.5E-77
score: 259.9
IPR004790Isocitrate dehydrogenase NADP-dependentTIGRFAMTIGR00127TIGR00127coord: 19..424
e-value: 3.5E-225
score: 745.1
IPR004790Isocitrate dehydrogenase NADP-dependentPIRSFPIRSF000108IDH_NADPcoord: 2..427
e-value: 1.6E-233
score: 772.2
IPR004790Isocitrate dehydrogenase NADP-dependentPANTHERPTHR11822NADP-SPECIFIC ISOCITRATE DEHYDROGENASEcoord: 13..425
NoneNo IPR availableGENE3DG3DSA:3.40.718.10coord: 17..427
e-value: 7.0E-230
score: 764.4
NoneNo IPR availablePANTHERPTHR11822:SF11ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIALcoord: 13..425
NoneNo IPR availableSUPERFAMILYSSF53659Isocitrate/Isopropylmalate dehydrogenase-likecoord: 18..424
IPR019818Isocitrate/isopropylmalate dehydrogenase, conserved sitePROSITEPS00470IDH_IMDHcoord: 287..306