Cysteine-rich venom protein

Overview


Name	Cysteine-rich venom protein
Smed ID	SMED30024253
Length (bp)	698

Neoblast Clusters

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Cysteine-rich venom protein (SMED30024253) t-SNE clustered cells

Violin plots show distribution of expression levels for Cysteine-rich venom protein (SMED30024253) in cells (dots) of each of the 12 neoblast clusters.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30024253

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
head region	SMED30024253	h1SMcG0011336	SmedASXL_000032	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
head region	SMED30024253	h1SMcG0011336	SmedASXL_021893	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
reproductive organ	SMED30024253	h1SMcG0011336	Contig35594	newmark_ests	PMID:28434803 Rouhana et al., 2017
reproductive organ	SMED30024253	h1SMcG0011336	Contig35594	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Cysteine-rich venom protein vs. Ensembl Human
Match: PI16 (peptidase inhibitor 16 [Source:HGNC Symbol;Acc:HGNC:21245])

HSP 1 Score: 115.161 bits (287), Expect = 2.765e-29
Identity = 67/179 (37.43%), Postives = 99/179 (55.31%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGF-VYPSSCTG--TCGHATQILWATTSSIGCGRATCNATDPNNE-NI-LITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            LTD EK+ M+ +HN  R+ V+PTA++M+ ++W++ L A A+ ++  CV+ H    N      G+NL+  T        DV LA+  W  E + + +  ++C+    CGH TQ++WA T  IGCG   C       E NI L+ C Y   GN+ G+  YQ G  CS CP+ Y  C+N LC
Sbjct:   28 LTDEEKRLMVELHNLYRAQVSPTASDMLHMRWDEELAAFAKAYARQCVWGH----NKERGRRGENLFAITDEG----MDVPLAMEEWHHEREHYNLSAATCSPGQMCGHYTQVVWAKTERIGCGSHFCEKLQGVEETNIELLVCNYEPPGNVKGKRPYQEGTPCSQCPSGY-HCKNSLC 197

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Query:   46 LTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGF-VYPSSCTG--TCGHATQILWATTSSIGCGRATCNATDPNNE-NI-LITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            LTD EK+ M+ +HN  R+ V+PTA++M+ ++W++ L A A+ ++  CV+ H    N      G+NL+  T        DV LA+  W  E + + +  ++C+    CGH TQ++WA T  IGCG   C       E NI L+ C Y   GN+ G+  YQ G  CS CP+ Y  C+N LC
Sbjct:   28 LTDEEKRLMVELHNLYRAQVSPTASDMLHMRWDEELAAFAKAYARQCVWGH----NKERGRRGENLFAITDEG----MDVPLAMEEWHHEREHYNLSAATCSPGQMCGHYTQVVWAKTERIGCGSHFCEKLQGVEETNIELLVCNYEPPGNVKGKRPYQEGTPCSQCPSGY-HCKNSLC 197

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Query:   46 LTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGF-VYPSSCTG--TCGHATQILWATTSSIGCGRATCNATDPNNE-NI-LITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            LTD EK+ M+ +HN  R+ V+PTA++M+ ++W++ L A A+ ++  CV+ H    N      G+NL+  T        DV LA+  W  E + + +  ++C+    CGH TQ++WA T  IGCG   C       E NI L+ C Y   GN+ G+  YQ G  CS CP+ Y  C+N LC
Sbjct:   28 LTDEEKRLMVELHNLYRAQVSPTASDMLHMRWDEELAAFAKAYARQCVWGH----NKERGRRGENLFAITDEG----MDVPLAMEEWHHEREHYNLSAATCSPGQMCGHYTQVVWAKTERIGCGSHFCEKLQGVEETNIELLVCNYEPPGNVKGKRPYQEGTPCSQCPSGY-HCKNSLC 197

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BLAST of Cysteine-rich venom protein vs. Ensembl Human
Match: CRISP2 (cysteine rich secretory protein 2 [Source:HGNC Symbol;Acc:HGNC:12024])

HSP 1 Score: 103.219 bits (256), Expect = 2.771e-26
Identity = 61/177 (34.46%), Postives = 96/177 (54.24%), Query Frame = 1

Query:   61 KQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHP-AEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVY---PSSCTGTCGHATQILWATTSSIGCGRATCNATDPNNENI--LITCQYWLRGNILGQ--TLYQSGVSCSNCPTPYPDCENKLC 567
            ++ ++N HN+ R  V+P A+NM+K++W++ +   A+ W++ C  QH   ED    +  G+NLY+++ P S +      A+ +W  E   FVY   P S     GH TQ++W +T  +GCG A C    PN +++     CQY   GN + +  T YQ G  C+ CP    DC+  LC
Sbjct:   37 QREIVNKHNELRKAVSPPASNMLKMEWSREVTTNAQRWANKCTLQHSDPEDRKTSTRCGENLYMSSDPTSWSS-----AIQSWYDEILDFVYGVGPKSPNAVVGHYTQLVWYSTYQVGCGIAYC----PNQDSLKYYYVCQYCPAGNNMNRKNTPYQQGTPCAGCPD---DCDKGLC 201

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Query:   61 KQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHP-AEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVY---PSSCTGTCGHATQILWATTSSIGCGRATCNATDPNNENI--LITCQYWLRGNILGQ--TLYQSGVSCSNCPTPYPDCENKLC 567
            ++ ++N HN+ R  V+P A+NM+K++W++ +   A+ W++ C  QH   ED    +  G+NLY+++ P S +      A+ +W  E   FVY   P S     GH TQ++W +T  +GCG A C    PN +++     CQY   GN + +  T YQ G  C+ CP    DC+  LC
Sbjct:   37 QREIVNKHNELRKAVSPPASNMLKMEWSREVTTNAQRWANKCTLQHSDPEDRKTSTRCGENLYMSSDPTSWSS-----AIQSWYDEILDFVYGVGPKSPNAVVGHYTQLVWYSTYQVGCGIAYC----PNQDSLKYYYVCQYCPAGNNMNRKNTPYQQGTPCAGCPD---DCDKGLC 201

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BLAST of Cysteine-rich venom protein vs. Ensembl Celegans
Match: scl-7 (SCP-Like extracellular protein [Source:UniProtKB/TrEMBL;Acc:Q18539])

HSP 1 Score: 102.834 bits (255), Expect = 8.058e-27
Identity = 67/191 (35.08%), Postives = 94/191 (49.21%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMV-----------NPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYD--VDLAVLAWIKESQGFVYPSSCTGTC------GHATQILWATTSSIGCGRATCNATD--PNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCE 555
             ++  KQSM+N HN  RS +             +ATNM+K++W+ +L   A+N+++ C  QH  +      SYG+NL+ A     IT  D  V  AV  W+ E Q F + S+   T       GHATQ+ W+ T  +GCG   C A      +    I CQY + GN L + +Y SG  CS CP     CE
Sbjct:   18 FSEGGKQSMVNAHNAVRSSIAKGEYVAKGTKKDSATNMLKMKWDNSLAQSAQNYANGCPMQHSPDK-----SYGENLFWAYSSSPITDLDKYVQSAVDTWVSEFQMFGWNSNKFTTALWNTGIGHATQVAWSATGQVGCGAKNCGADSVRVGSYKATIVCQYKVPGNYLFKNIYNSGAKCSACPAG-TSCE 202

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BLAST of Cysteine-rich venom protein vs. Ensembl Celegans
Match: scl-8 (SCP-Like extracellular protein [Source:UniProtKB/TrEMBL;Acc:Q18540])

HSP 1 Score: 99.7525 bits (247), Expect = 1.188e-25
Identity = 66/192 (34.38%), Postives = 94/192 (48.96%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMV-----------NPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDV--DLAVLAWIKESQGFVYPSSC-------TGTCGHATQILWATTSSIGCGRATC--NATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCE 555
             ++  KQS+LN HN  RS +             +ATNM+K++W+ +LE  A+N+++ C  QH   D     + G+NLY        +  D    +A +AW  E + F + S+        TG   HATQI WA T  IGCG   C  +A       + I CQY +RGN   + +Y SG +CS CP     CE
Sbjct:   18 FSEGGKQSILNAHNDIRSRIAKGNYVAKGNRKESATNMLKMKWDSSLEQSAQNYANGCHMQHSTND----KTIGENLYWEWSGDPFSDLDKFGKIATVAWDHEFEQFGWNSNKFSLALFNTGVA-HATQIAWAPTGKIGCGVKNCGRDARRGGLFQVAIVCQYRVRGNFFFKNIYNSGATCSACPAG-TSCE 203

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BLAST of Cysteine-rich venom protein vs. Ensembl Celegans
Match: scl-1 (SCP-Like extracellular protein [Source:UniProtKB/TrEMBL;Acc:Q20608])

HSP 1 Score: 93.5893 bits (231), Expect = 2.817e-23
Identity = 64/200 (32.00%), Postives = 100/200 (50.00%), Query Frame = 1

Query:   34 VDPLLTDSEKQSMLNIHNQNRSMVNPT-----------ATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDV--DLAVLAWIKESQGFVYPSSCTGTC------GHATQILWATTSSIGCGRATC--NATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYP-DCENKLC 567
            V+   T + + S+++ HN+ RS +  +           AT+M K+  + T+ A A+N+++ C   H        + YG+NLY +     +   D   ++A  AW KE Q F + S+   T       GHATQ+ WA TSSIGCG   C  +A+  N   I + CQY   GN +G+ +Y+ G +CS+C      D  + LC
Sbjct:   12 VNAQFTSTGQSSIVDAHNKLRSAIAKSTYVAKGTKKEPATDMRKMVVDSTVAASAQNYANTCPTGHSKG-----TGYGENLYWSWTSADVGSLDSYGEIAAAAWEKEFQDFGWKSNAMDTTLFNSGIGHATQMAWANTSSIGCGVKNCGRDASMRNMNKIAVVCQYSPPGNTMGRPIYKEGTTCSSCSGSTKCDTASGLC 206

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BLAST of Cysteine-rich venom protein vs. Ensembl Celegans
Match: scl-10 (SCP-Like extracellular protein [Source:UniProtKB/TrEMBL;Acc:Q20609])

HSP 1 Score: 93.2041 bits (230), Expect = 3.568e-23
Identity = 67/207 (32.37%), Postives = 106/207 (51.21%), Query Frame = 1

Query:    1 LIFTVFFHFQIVDPLLTDSEKQSMLNIHNQNRSMV-----------NPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDL----AVLAWIKESQGFVYPSSC------TGTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCEN 558
            LI  + F F       +++ K  +L+ HN  RS +            P+A+NM+KL W+ TLE  A+++S+ C    P   +A+ ++ G+N+Y  T P  +T  D +L    +   W  E Q F +  +           GHATQ+ WATT+ IGCG + C ++D      ++ C Y   GN +G  +Y+SG +CSNCP    +CE+
Sbjct:    7 LICLLIFSFCETLCEFSETGKNYILSRHNYLRSQIALGKYVAGNSTKPSASNMMKLIWDTTLETTAQDYSTGC----PTGHSASRANIGENMYWWTSPV-VTQTDAELLGNRSANLWESEFQRFGWNGNLLTEELFNSGIGHATQMAWATTNKIGCGISKC-SSDSFGTQYVVVCLYSPAGNYIGMDIYKSGETCSNCPDG-TNCES 206

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BLAST of Cysteine-rich venom protein vs. Ensembl Celegans
Match: scl-5 (SCP-Like extracellular protein [Source:UniProtKB/TrEMBL;Acc:Q18543])

HSP 1 Score: 89.7373 bits (221), Expect = 6.858e-22
Identity = 61/185 (32.97%), Postives = 91/185 (49.19%), Query Frame = 1

Query:   61 KQSMLNIHNQNRSMV-----------NPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAV--LAWIKESQGFVYPSSC-------TGTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCE 555
            + ++LN+HN  RS +            P A++M+K++W+ T+ A A+ +++ C   H        +  G+NLY      +IT  D   A    AW KE Q + + S+        TG  GHATQ+ WA T+ IGCG   C         + + CQY  +GN L Q +Y SG +CS CP+    CE
Sbjct:   24 QAAILNVHNTLRSRIAKGTYVAKGTAKPAASDMLKMKWDATVAASAQAYANKCPTGHSGA-----AGLGENLYWYWTSATITNIDQFGATGSAAWEKEFQDYGWSSNTLSMSLFNTGI-GHATQMAWAKTNLIGCGVKNCGKDTNGFNKVTVVCQYKPQGNYLNQNIYTSGTTCSKCPSG-TSCE 201

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BLAST of Cysteine-rich venom protein vs. Ensembl Fly
Match: CG8483 (gene:FBgn0038126 transcript:FBtr0082782)

HSP 1 Score: 82.0333 bits (201), Expect = 5.892e-18
Identity = 53/176 (30.11%), Postives = 83/176 (47.16%), Query Frame = 1

Query:   28 QIVDPLLTDSEKQSMLNIHNQNRSMV-------NPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYL--ATRPKSITPYDVDLAVLAWIKESQGFVYPSSCTGTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQTLYQSGV-SCS 525
            +I+   +T  E+  +L  HN+ R +V        P A NM ++ W+  L A A+ W+  C F+H         + GQNL +  +T P      D    + +W  E Q + +  + +   GH +Q++W  TS +GCG A     D +  N L  C Y   GN++G   Y+ G  SCS
Sbjct:   26 KIIASGITAEERSIILQEHNRLRQIVATGRYPGQPGAENMREIVWDDELAARAQKWADNCQFRHDPHRTINRFTMGQNLAIIWSTAPLDADDGDFPSRIQSWFNEVQKYSFGDAWSPKTGHYSQLVWGETSLVGCGYAEYK--DTSKYNKLYVCNYGPGGNVVGYNPYEVGKPSCS 199

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BLAST of Cysteine-rich venom protein vs. Ensembl Fly
Match: CG9400 (gene:FBgn0030562 transcript:FBtr0073920)

HSP 1 Score: 55.8398 bits (133), Expect = 5.109e-9
Identity = 45/180 (25.00%), Postives = 77/180 (42.78%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMVNP-------TATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSY-GQNL--YLATRPKSITPYDVDLAVLAWIKE----SQGFV---YPSSCTGTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCP 534
            +++  +Q +L++HN  RS +         +A +M  L+W+  LE +A   +  C F H    N     + GQN+  +   R        +   V+ W +E    +Q F+   +P       GH T ++    + +GC          N    ++TC Y    NI  + +YQSG + S CP
Sbjct:   91 MSERRRQLLLDMHNLARSKIASGNLDGYRSAAHMPLLRWDTELEQMAALHAKRCQFAHDKCRNTPRFKFSGQNIGYFWIGREFKSHSRRMKSFVINWFREHQDANQSFIDRYHPHPQGKKIGHFTLLVSDRVNRVGCAGVRFLEPKSNRFQFMLTCNYDY-NNIFNEPIYQSGPAGSKCP 269

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BLAST of Cysteine-rich venom protein vs. Ensembl Fly
Match: CG32679 (gene:FBgn0052679 transcript:FBtr0071469)

HSP 1 Score: 50.8322 bits (120), Expect = 2.409e-7
Identity = 47/178 (26.40%), Postives = 77/178 (43.26%), Query Frame = 1

Query:   52 DSEKQSMLNIHNQNRSMVN-------PTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNA-AYSSYGQNL-YLATRPKSITPYDVDLAVLAWIKESQGFV------YPSSCTGTCGHATQILWATTSSIGCGRATCNATDPNN-ENILITCQYWLRGNILGQTLYQSGVSCSNCPT 537
            D+    +L +HN+ R+++        P+A  M  + W+ TL  LA   +  C   H    N   Y   GQNL  L TR   +  + +   + AW  E++         Y        GH T ++    + +GC  A    TD NN +  L+ C Y +  N++   +Y++G + S C T
Sbjct:   58 DAHIPLILQLHNERRNLIAGGGVSGFPSAVQMATMSWDTTLAQLAAYNALQCRMAHDECRNTNTYRYAGQNLSILFTRSVDVAVF-LRQRIAAWFDENRDATSGDMEDYQMRGGPAIGHFTTMVNERNNRVGC--AIARFTDANNVQATLLACNYAVT-NVVNNPVYRAGTAASECTT 231

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BLAST of Cysteine-rich venom protein vs. Ensembl Fly
Match: Ag5r (gene:FBgn0015010 transcript:FBtr0333658)

HSP 1 Score: 46.2098 bits (108), Expect = 9.012e-6
Identity = 49/182 (26.92%), Postives = 81/182 (44.51%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMVN-------PTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNA-AYSSYGQNLYLAT--RPKSITPYDVDLAVLAWIKES----QGFV--YPSSCTG-TCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQTLYQS-GVSCSNCPT 537
            L+ +EK +++   N+ R+ +          A  M  ++WN  L  LA      C  +H    N  A+   GQNL       P ++T Y ++  V  W  E+    Q ++  YPS+  G   GH T ++    + +GC  AT + +  + +  L+ C Y    N+LG  +Y S   + S C T
Sbjct:   54 LSSAEKDALVARTNEYRNHIAGGLNANLSAACRMATIKWNDELAYLASLNVKSCQMKHDGCHNTDAFDWSGQNLAWMGYYNPLNVTHY-LEWGVDMWYDEAVYTKQAYIDAYPSNYNGPAIGHFTVLVADRNTEVGCAAATYSVSGQSYKAFLLACNY-AATNVLGIKMYSSCSKAASKCTT 233

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BLAST of Cysteine-rich venom protein vs. Ensembl Fly
Match: Ag5r (gene:FBgn0015010 transcript:FBtr0073937)

HSP 1 Score: 46.2098 bits (108), Expect = 9.012e-6
Identity = 49/182 (26.92%), Postives = 81/182 (44.51%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMVN-------PTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNA-AYSSYGQNLYLAT--RPKSITPYDVDLAVLAWIKES----QGFV--YPSSCTG-TCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQTLYQS-GVSCSNCPT 537
            L+ +EK +++   N+ R+ +          A  M  ++WN  L  LA      C  +H    N  A+   GQNL       P ++T Y ++  V  W  E+    Q ++  YPS+  G   GH T ++    + +GC  AT + +  + +  L+ C Y    N+LG  +Y S   + S C T
Sbjct:   54 LSSAEKDALVARTNEYRNHIAGGLNANLSAACRMATIKWNDELAYLASLNVKSCQMKHDGCHNTDAFDWSGQNLAWMGYYNPLNVTHY-LEWGVDMWYDEAVYTKQAYIDAYPSNYNGPAIGHFTVLVADRNTEVGCAAATYSVSGQSYKAFLLACNY-AATNVLGIKMYSSCSKAASKCTT 233

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BLAST of Cysteine-rich venom protein vs. Ensembl Zebrafish
Match: r3hdml (R3H domain containing-like [Source:ZFIN;Acc:ZDB-GENE-090313-275])

HSP 1 Score: 103.219 bits (256), Expect = 2.687e-26
Identity = 62/179 (34.64%), Postives = 96/179 (53.63%), Query Frame = 1

Query:   43 LLTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNL-YLATRPKSITPYDVDLAVLAWIKESQGFVYPSSCTGT-CGHATQILWATTSSIGCGRATCNAT----DPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENK 561
             ++  +  ++L+ HN+ RS V P A NM  + W++ L   AE W+S C+++H       +   GQNL  ++ R KSI    +DL V +W  E   F YPS C+G+ C H TQ++WA ++ IGC    C+          +  L+ C Y ++GN +G+  Y+ G  CS CP+ Y    NK
Sbjct:   60 FISGKDMTALLDYHNRVRSQVFPPAANMEYMVWDERLAKSAEFWASQCIWEHGPHHFLQH--IGQNLSIISGRYKSI----IDL-VKSWYDERHSFSYPSRCSGSVCTHYTQMVWAASNKIGCAIKKCSDIFVFGSMWKQATLLVCNYAIKGNWVGEAPYKIGRPCSACPSSYGGSCNK 231

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Query:   43 LLTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNL-YLATRPKSITPYDVDLAVLAWIKESQGFVYPSSCTGT-CGHATQILWATTSSIGCGRATCNAT----DPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENK 561
             ++  +  ++L+ HN+ RS V P A NM  + W++ L   AE W+S C+++H       +   GQNL  ++ R KSI    +DL V +W  E   F YPS C+G+ C H TQ++WA ++ IGC    C+          +  L+ C Y ++GN +G+  Y+ G  CS CP+ Y    NK
Sbjct:   60 FISGKDMTALLDYHNRVRSQVFPPAANMEYMVWDERLAKSAEFWASQCIWEHGPHHFLQH--IGQNLSIISGRYKSI----IDL-VKSWYDERHSFSYPSRCSGSVCTHYTQMVWAASNKIGCAIKKCSDIFVFGSMWKQATLLVCNYAIKGNWVGEAPYKIGRPCSACPSSYGGSCNK 231

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BLAST of Cysteine-rich venom protein vs. Ensembl Zebrafish
Match: glipr1a (GLI pathogenesis-related 1a [Source:ZFIN;Acc:ZDB-GENE-110309-2])

HSP 1 Score: 102.449 bits (254), Expect = 4.396e-26
Identity = 64/202 (31.68%), Postives = 97/202 (48.02%), Query Frame = 1

Query:    4 IFTVFFHFQIVDPLLTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAA------YSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSS-CTG--TCGHATQILWATTSSIGCGRATC-----NATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            +F+  + F I D    D      +  HNQNRS V+PTA NM  + W+  L   A  W+  C+F+H      A      +++ G+N++ A  P S   + V  AV +W+ E + + Y ++ C     CGH TQ++WA +  +GC   TC          N + ++  C Y   GN  G++ Y+ G SCS C      CE  LC
Sbjct:   17 VFSSEYLFDITDRAFIDE----CVREHNQNRSSVSPTAANMRYMTWDAALAVTARAWARFCLFKHNIHLREAKRVHPTFTTVGENIW-AGAPYS--RFTVKSAVFSWVNELKDYNYNNNQCNDKKVCGHYTQVVWADSYKVGCAVQTCPNGVAETHFSNIQGVIFVCNYATAGNFAGRSPYKQGASCSGCGGS-DKCERNLC 210

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BLAST of Cysteine-rich venom protein vs. Ensembl Zebrafish
Match: glipr1a (GLI pathogenesis-related 1a [Source:ZFIN;Acc:ZDB-GENE-110309-2])

HSP 1 Score: 101.679 bits (252), Expect = 1.395e-25
Identity = 64/202 (31.68%), Postives = 97/202 (48.02%), Query Frame = 1

Query:    4 IFTVFFHFQIVDPLLTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAA------YSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSS-CTG--TCGHATQILWATTSSIGCGRATC-----NATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            +F+  + F I D    D      +  HNQNRS V+PTA NM  + W+  L   A  W+  C+F+H      A      +++ G+N++ A  P S   + V  AV +W+ E + + Y ++ C     CGH TQ++WA +  +GC   TC          N + ++  C Y   GN  G++ Y+ G SCS C      CE  LC
Sbjct:   25 VFSSEYLFDITDRAFIDE----CVREHNQNRSSVSPTAANMRYMTWDAALAVTARAWARFCLFKHNIHLREAKRVHPTFTTVGENIW-AGAPYS--RFTVKSAVFSWVNELKDYNYNNNQCNDKKVCGHYTQVVWADSYKVGCAVQTCPNGVAETHFSNIQGVIFVCNYATAGNFAGRSPYKQGASCSGCGGS-DKCERNLC 218

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BLAST of Cysteine-rich venom protein vs. Ensembl Zebrafish
Match: crispld2 (cysteine-rich secretory protein LCCL domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-130131-1])

HSP 1 Score: 95.1301 bits (235), Expect = 3.330e-22
Identity = 61/187 (32.62%), Postives = 90/187 (48.13%), Query Frame = 1

Query:   55 SEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVY----------PSSCTG-TCGHATQILWATTSSIGCGRATCNATDPNNE----NILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPD-CENKLC 567
            S+++ +L +HN+ R  V PTA+NM  + W+  LE  A +W+  C ++H  +D     S GQNL +         Y V     AW  E + + Y          P  C+G  C H TQ++WATT+ +GC    C   +   E     + + C Y  +GN +G+  YQ G  CS CP  Y   C + LC
Sbjct:   63 SDREEILKLHNKLRGEVYPTASNMEYMIWDDELERSATSWAEQCQWEHGPQD--LLMSIGQNLAVHWGRYRSPAYHVQ----AWYDEVKDYTYPYPHECNPWCPERCSGPMCTHYTQLVWATTNRVGCAVHVCPRMNVWGEIWENAVYLVCNYSPKGNWIGEAPYQHGRPCSQCPPSYGGVCRDNLC 243

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BLAST of Cysteine-rich venom protein vs. Ensembl Xenopus
Match: ENSXETT00000036788.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:KV464547.1:593:5826:1 gene:ENSXETG00000015856.1 transcript:ENSXETT00000036788.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 99.7525 bits (247), Expect = 5.434e-24
Identity = 59/176 (33.52%), Postives = 97/176 (55.11%), Query Frame = 1

Query:   55 SEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSSC---TGTCGHATQILWATTSSIGCGRATCNATDP-NNENI-LITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
             EK+ +L+ HN  RS   P+A++MIKL W+  LEA+A++++  C+++H    N      G+NL++     S +  DV L +  W KE   + + +        CGH TQ++WA T  +GCG+  C   +  ++EN+ L+ C Y   GN  G++ Y+ G  C+ CP+ +  C   LC
Sbjct:   33 EEKRIILDKHNFYRSQTEPSASDMIKLTWDSALEAMAKSYAEKCIWEH----NKDRGFIGENLFVM----SGSSLDVALGLDDWHKERGYYNFTTGMCQEGQMCGHYTQMVWAGTERVGCGQNFCPKLEGVDDENMYLLVCNYEPPGNFEGESPYKEGSRCTECPSDHV-CIGSLC 199

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BLAST of Cysteine-rich venom protein vs. Ensembl Xenopus
Match: crispld2 (cysteine-rich secretory protein LCCL domain containing 2 [Source:NCBI gene;Acc:613091])

HSP 1 Score: 99.3673 bits (246), Expect = 1.641e-23
Identity = 60/187 (32.09%), Postives = 93/187 (49.73%), Query Frame = 1

Query:   55 SEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVY----------PSSCTG-TCGHATQILWATTSSIGCGRATCNAT----DPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPY-PDCENKLC 567
            ++K+ ++ +HN+ R  V+P+A+NM  + W+  LE  AE W+  C+++H     A   S GQNL +         Y V     +W  E + + Y          P  C+G  C H TQI+WATT+ +GC    C       D     + + C Y  +GN +G+  Y++G  CS CP  Y  +C+N LC
Sbjct:   55 TDKEEIIQLHNKLRGQVHPSASNMEYMTWDDELEKSAEAWAEECIWEHGP--TALLMSIGQNLAVHWGRYRQPAYHVQ----SWYDEVKDYTYPYPHECNPYCPERCSGPMCTHYTQIVWATTTKVGCAVNVCKRMNVWGDIWENAVYLVCNYSPKGNWIGEAPYKNGRPCSECPPSYGGNCQNNLC 235

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BLAST of Cysteine-rich venom protein vs. Ensembl Xenopus
Match: crispld2 (cysteine-rich secretory protein LCCL domain containing 2 [Source:NCBI gene;Acc:613091])

HSP 1 Score: 99.3673 bits (246), Expect = 1.736e-23
Identity = 60/187 (32.09%), Postives = 93/187 (49.73%), Query Frame = 1

Query:   55 SEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVY----------PSSCTG-TCGHATQILWATTSSIGCGRATCNAT----DPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPY-PDCENKLC 567
            ++K+ ++ +HN+ R  V+P+A+NM  + W+  LE  AE W+  C+++H     A   S GQNL +         Y V     +W  E + + Y          P  C+G  C H TQI+WATT+ +GC    C       D     + + C Y  +GN +G+  Y++G  CS CP  Y  +C+N LC
Sbjct:   55 TDKEEIIQLHNKLRGQVHPSASNMEYMTWDDELEKSAEAWAEECIWEHGP--TALLMSIGQNLAVHWGRYRQPAYHVQ----SWYDEVKDYTYPYPHECNPYCPERCSGPMCTHYTQIVWATTTKVGCAVNVCKRMNVWGDIWENAVYLVCNYSPKGNWIGEAPYKNGRPCSECPPSYGGNCQNNLC 235

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BLAST of Cysteine-rich venom protein vs. Ensembl Xenopus
Match: crispld2 (cysteine-rich secretory protein LCCL domain containing 2 [Source:NCBI gene;Acc:613091])

HSP 1 Score: 98.9821 bits (245), Expect = 1.904e-23
Identity = 60/187 (32.09%), Postives = 93/187 (49.73%), Query Frame = 1

Query:   55 SEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVY----------PSSCTG-TCGHATQILWATTSSIGCGRATCNAT----DPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPY-PDCENKLC 567
            ++K+ ++ +HN+ R  V+P+A+NM  + W+  LE  AE W+  C+++H     A   S GQNL +         Y V     +W  E + + Y          P  C+G  C H TQI+WATT+ +GC    C       D     + + C Y  +GN +G+  Y++G  CS CP  Y  +C+N LC
Sbjct:   55 TDKEEIIQLHNKLRGQVHPSASNMEYMTWDDELEKSAEAWAEECIWEHGP--TALLMSIGQNLAVHWGRYRQPAYHVQ----SWYDEVKDYTYPYPHECNPYCPERCSGPMCTHYTQIVWATTTKVGCAVNVCKRMNVWGDIWENAVYLVCNYSPKGNWIGEAPYKNGRPCSECPPSYGGNCQNNLC 235

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BLAST of Cysteine-rich venom protein vs. Ensembl Xenopus
Match: stn1 (STN1, CST complex subunit [Source:Xenbase;Acc:XB-GENE-988862])

HSP 1 Score: 91.2781 bits (225), Expect = 9.213e-22
Identity = 62/180 (34.44%), Postives = 92/180 (51.11%), Query Frame = 1

Query:   49 TDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSY--GQNLYLATRPKSITPYDVDLAVLAWIKESQGFVY---PSSCTGTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILG--QTLYQSGVSCSNCPTPYPDCENKLC 567
            T + +Q +++ HN  R  VNP+A NM+K+ W++   + A  WS+ C   H        S    G+N+++A+ P S        A+ AW  ESQ F Y   P+S     GH TQ++W  +  +GC  + C     NN+ I + CQY   GN L    T Y+SG +C +CP     C+N LC
Sbjct:   30 TSTVQQVIVDTHNGYRRSVNPSARNMLKMMWSEAAASNAATWSATCPAAHSPTSQRTISGVTCGENIFIASYPASW-----QEAITAWNSESQYFQYGVGPTSSNQVTGHYTQLVWYNSYMVGCAVSNC-----NNQYIYV-CQYCPMGNNLNTITTPYKSGPACGDCPGA---CDNGLC 195

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BLAST of Cysteine-rich venom protein vs. Ensembl Mouse
Match: Pi16 (peptidase inhibitor 16 [Source:MGI Symbol;Acc:MGI:1921366])

HSP 1 Score: 115.931 bits (289), Expect = 3.040e-31
Identity = 67/179 (37.43%), Postives = 99/179 (55.31%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSSCTG---TCGHATQILWATTSSIGCGRATCNATDPNNE-NI-LITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            LT+ EKQ+M+++HNQ R+ V+P A++M++++W+  L A A+ ++  CV+ H    N      G+NL+  T        DV LAV  W +E + + + ++       CGH TQ++W+ T  IGCG   C       E NI L+ C Y   GN+ G+  YQ G  CS CP  Y  CEN LC
Sbjct:   30 LTEDEKQTMVDLHNQYRAQVSPPASDMLQMRWDDELAAFAKAYAQKCVWGH----NKERGRRGENLFAITDEG----MDVPLAVGNWHEEHEYYNFSTATCDPNQMCGHYTQVVWSKTERIGCGSHFCETLQGVEEANIHLLVCNYEPPGNVKGRKPYQEGTPCSQCPLGY-SCENSLC 199

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BLAST of Cysteine-rich venom protein vs. Ensembl Mouse
Match: Pi16 (peptidase inhibitor 16 [Source:MGI Symbol;Acc:MGI:1921366])

HSP 1 Score: 116.701 bits (291), Expect = 3.288e-31
Identity = 67/179 (37.43%), Postives = 99/179 (55.31%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSSC---TGTCGHATQILWATTSSIGCGRATCNATDPNNE-NI-LITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            LT+ EKQ+M+++HNQ R+ V+P A++M++++W+  L A A+ ++  CV+ H    N      G+NL+  T        DV LAV  W +E + + + ++       CGH TQ++W+ T  IGCG   C       E NI L+ C Y   GN+ G+  YQ G  CS CP  Y  CEN LC
Sbjct:   30 LTEDEKQTMVDLHNQYRAQVSPPASDMLQMRWDDELAAFAKAYAQKCVWGH----NKERGRRGENLFAITDEG----MDVPLAVGNWHEEHEYYNFSTATCDPNQMCGHYTQVVWSKTERIGCGSHFCETLQGVEEANIHLLVCNYEPPGNVKGRKPYQEGTPCSQCPLGY-SCENSLC 199

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Query:   46 LTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSSC---TGTCGHATQILWATTSSIGCGRATCNATDPNNE-NI-LITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            LT+ EKQ+M+++HNQ R+ V+P A++M++++W+  L A A+ ++  CV+ H    N      G+NL+  T        DV LAV  W +E + + + ++       CGH TQ++W+ T  IGCG   C       E NI L+ C Y   GN+ G+  YQ G  CS CP  Y  CEN LC
Sbjct:   30 LTEDEKQTMVDLHNQYRAQVSPPASDMLQMRWDDELAAFAKAYAQKCVWGH----NKERGRRGENLFAITDEG----MDVPLAVGNWHEEHEYYNFSTATCDPNQMCGHYTQVVWSKTERIGCGSHFCETLQGVEEANIHLLVCNYEPPGNVKGRKPYQEGTPCSQCPLGY-SCENSLC 199

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BLAST of Cysteine-rich venom protein vs. Ensembl Mouse
Match: Pi16 (peptidase inhibitor 16 [Source:MGI Symbol;Acc:MGI:1921366])

HSP 1 Score: 117.857 bits (294), Expect = 3.510e-30
Identity = 67/179 (37.43%), Postives = 99/179 (55.31%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSSC---TGTCGHATQILWATTSSIGCGRATCNATDPNNE-NI-LITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            LT+ EKQ+M+++HNQ R+ V+P A++M++++W+  L A A+ ++  CV+ H    N      G+NL+  T        DV LAV  W +E + + + ++       CGH TQ++W+ T  IGCG   C       E NI L+ C Y   GN+ G+  YQ G  CS CP  Y  CEN LC
Sbjct:   30 LTEDEKQTMVDLHNQYRAQVSPPASDMLQMRWDDELAAFAKAYAQKCVWGH----NKERGRRGENLFAITDEG----MDVPLAVGNWHEEHEYYNFSTATCDPNQMCGHYTQVVWSKTERIGCGSHFCETLQGVEEANIHLLVCNYEPPGNVKGRKPYQEGTPCSQCPLGY-SCENSLC 199

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BLAST of Cysteine-rich venom protein vs. Ensembl Mouse
Match: Glipr1l1 (GLI pathogenesis-related 1 like 1 [Source:MGI Symbol;Acc:MGI:1916536])

HSP 1 Score: 98.5969 bits (244), Expect = 1.078e-24
Identity = 69/189 (36.51%), Postives = 89/189 (47.09%), Query Frame = 1

Query:   31 IVDPLLTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQH------PAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYP-SSCTGTCGHATQILWATTSSIGCGRATCNATDPNNENI---LITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            I DP   D+     LNIHN+ R  V P A +M +L W+Q L  LA+ W+  C   H        E    Y   G+N+YL        P DV   V+ W  ES+ F +  ++C+  CGH TQ++WA T  IGC  + C    PN +     L  C Y   GN +G   Y  G SCS C      CEN LC
Sbjct:   36 ITDPKFIDA----FLNIHNELRRKVQPPAADMNQLFWDQQLAKLAKAWTRECKLAHNPCIKQRYECLEDYDFIGENIYLGR--IETQPEDV---VINWYNESKYFNFDFNTCSEMCGHYTQVVWAKTVKIGCAVSNC----PNLKGFSAGLFVCNYSPAGNFIGFRPYTRGDSCSMCGQ--KTCENSLC 209

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BLAST of Cysteine-rich venom protein vs. UniProt/SwissProt
Match: sp|Q9ET66|PI16_MOUSE (Peptidase inhibitor 16 OS=Mus musculus OX=10090 GN=Pi16 PE=1 SV=2)

HSP 1 Score: 117.857 bits (294), Expect = 2.455e-29
Identity = 67/179 (37.43%), Postives = 99/179 (55.31%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSSC---TGTCGHATQILWATTSSIGCGRATCNATDPNNE-NI-LITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            LT+ EKQ+M+++HNQ R+ V+P A++M++++W+  L A A+ ++  CV+ H    N      G+NL+  T        DV LAV  W +E + + + ++       CGH TQ++W+ T  IGCG   C       E NI L+ C Y   GN+ G+  YQ G  CS CP  Y  CEN LC
Sbjct:   30 LTEDEKQTMVDLHNQYRAQVSPPASDMLQMRWDDELAAFAKAYAQKCVWGH----NKERGRRGENLFAITDEG----MDVPLAVGNWHEEHEYYNFSTATCDPNQMCGHYTQVVWSKTERIGCGSHFCETLQGVEEANIHLLVCNYEPPGNVKGRKPYQEGTPCSQCPLGY-SCENSLC 199

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BLAST of Cysteine-rich venom protein vs. UniProt/SwissProt
Match: sp|Q6UXB8|PI16_HUMAN (Peptidase inhibitor 16 OS=Homo sapiens OX=9606 GN=PI16 PE=1 SV=1)

HSP 1 Score: 115.161 bits (287), Expect = 1.328e-28
Identity = 67/179 (37.43%), Postives = 99/179 (55.31%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGF-VYPSSCTG--TCGHATQILWATTSSIGCGRATCNATDPNNE-NI-LITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            LTD EK+ M+ +HN  R+ V+PTA++M+ ++W++ L A A+ ++  CV+ H    N      G+NL+  T        DV LA+  W  E + + +  ++C+    CGH TQ++WA T  IGCG   C       E NI L+ C Y   GN+ G+  YQ G  CS CP+ Y  C+N LC
Sbjct:   28 LTDEEKRLMVELHNLYRAQVSPTASDMLHMRWDEELAAFAKAYARQCVWGH----NKERGRRGENLFAITDEG----MDVPLAMEEWHHEREHYNLSAATCSPGQMCGHYTQVVWAKTERIGCGSHFCEKLQGVEETNIELLVCNYEPPGNVKGKRPYQEGTPCSQCPSGY-HCKNSLC 197

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BLAST of Cysteine-rich venom protein vs. UniProt/SwissProt
Match: sp|Q58D34|PI16_BOVIN (Peptidase inhibitor 16 OS=Bos taurus OX=9913 GN=PI16 PE=2 SV=1)

HSP 1 Score: 112.464 bits (280), Expect = 1.563e-27
Identity = 67/178 (37.64%), Postives = 94/178 (52.81%), Query Frame = 1

Query:   49 TDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPS-SCTG--TCGHATQILWATTSSIGCGRATCNATDPNNE-NI-LITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            ++ EK  M+ +HN  R+ V+P ATNM++++W++ L A A+ ++  CV+ H    N      G+NL+  T        DV LA+  W  E + +   + SC     CGH TQ++WA T  IGCG   C       E NI L+ C Y   GN+ GQ  YQ G  CS CP  Y  C+N LC
Sbjct:   29 SEEEKHVMVELHNLYRTQVSPPATNMLQMRWDEELAAFAKAYAQQCVWGH----NKERGRRGENLFAITGEG----LDVPLAMEEWHHEREHYNLSAISCAAGQMCGHYTQVVWAKTERIGCGSHFCEKLQGVEETNIHLLVCNYEPPGNVKGQRPYQEGTPCSQCPLGY-HCKNSLC 197

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BLAST of Cysteine-rich venom protein vs. UniProt/SwissProt
Match: sp|P16562|CRIS2_HUMAN (Cysteine-rich secretory protein 2 OS=Homo sapiens OX=9606 GN=CRISP2 PE=1 SV=1)

HSP 1 Score: 103.219 bits (256), Expect = 1.331e-25
Identity = 61/177 (34.46%), Postives = 96/177 (54.24%), Query Frame = 1

Query:   61 KQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHP-AEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVY---PSSCTGTCGHATQILWATTSSIGCGRATCNATDPNNENI--LITCQYWLRGNILGQ--TLYQSGVSCSNCPTPYPDCENKLC 567
            ++ ++N HN+ R  V+P A+NM+K++W++ +   A+ W++ C  QH   ED    +  G+NLY+++ P S +      A+ +W  E   FVY   P S     GH TQ++W +T  +GCG A C    PN +++     CQY   GN + +  T YQ G  C+ CP    DC+  LC
Sbjct:   37 QREIVNKHNELRKAVSPPASNMLKMEWSREVTTNAQRWANKCTLQHSDPEDRKTSTRCGENLYMSSDPTSWSS-----AIQSWYDEILDFVYGVGPKSPNAVVGHYTQLVWYSTYQVGCGIAYC----PNQDSLKYYYVCQYCPAGNNMNRKNTPYQQGTPCAGCPD---DCDKGLC 201

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BLAST of Cysteine-rich venom protein vs. UniProt/SwissProt
Match: sp|Q8JI39|CRVP_PROFL (Cysteine-rich venom protein triflin OS=Protobothrops flavoviridis OX=88087 PE=1 SV=1)

HSP 1 Score: 100.908 bits (250), Expect = 9.516e-25
Identity = 63/178 (35.39%), Postives = 93/178 (52.25%), Query Frame = 1

Query:   61 KQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSY--GQNLYLATRPKSITPYDVDLAVLAWIKESQGFVY-----PSSCTGTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQTL--YQSGVSCSNCPTPYPDCENKLC 567
            +  ++++HN  R  VNPTA+NM+K++W     A AE W+  C+  H + D+        G+N+Y+AT P   T  D+   + AW  E + F Y     PS      GH TQI+W  +   GC  A C ++     +    CQY   GNI+G+T   Y+SG  C +CP+   DC+N LC
Sbjct:   34 QNEIIDLHNSLRRSVNPTASNMLKMEWYPEAAANAERWAYRCIESHSSRDSRVIGGIKCGENIYMATYPAKWT--DI---IHAWHGEYKDFKYGVGAVPSD--AVIGHYTQIVWYKSYRAGCAAAYCPSS---KYSYFYVCQYCPAGNIIGKTATPYKSGPPCGDCPS---DCDNGLC 198

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BLAST of Cysteine-rich venom protein vs. TrEMBL
Match: A0A564YKT8 (SCP domain-containing protein (Fragment) OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS7413 PE=4 SV=1)

HSP 1 Score: 139.043 bits (349), Expect = 2.511e-36
Identity = 70/179 (39.11%), Postives = 106/179 (59.22%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPS-SCTGTCGHATQILWATTSSIGCGRATCN----ATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            L D+E+  +L+ HN  RS+V+P+A+NM+++ +N TLE+LA+ W + CV++HP   +  YS YGQNL + T     +  ++   V  W KE   + Y + +C+ TCGH TQ++WA +  IGC   TC      +    +   I CQY   GN +GQ  Y++G  CS+CP+ Y  C N LC
Sbjct:   19 LNDTERTQILSDHNGFRSIVSPSASNMLQMSYNTTLESLAQKWVNYCVWKHPGTSDVEYSGYGQNLGMTTA----SSLNLQTIVDMWDKEKADYTYSTNTCSKTCGHYTQVVWAKSLQIGCAYQTCTNFSIGSKTYPKAFFIACQYSPPGNYIGQKPYENGTPCSHCPSGYESCVNNLC 193

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BLAST of Cysteine-rich venom protein vs. TrEMBL
Match: A0A0R3WLM2 (SCP domain-containing protein OS=Hydatigena taeniaeformis OX=6205 GN=TTAC_LOCUS1647 PE=3 SV=1)

HSP 1 Score: 127.487 bits (319), Expect = 7.695e-32
Identity = 72/185 (38.92%), Postives = 98/185 (52.97%), Query Frame = 1

Query:    7 FTVFFHFQIVDPLLTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSY---GQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPS-SCTGTCGHATQILWATTSSIGCGRATCNATDP--NNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPY 543
             TV     IV PL TD E+  ML  H   R  V P A+NM+ ++++  LEALA+ W+S C F+HP  D+  Y  Y   GQN+ L    K         AV  W  E + + Y S +C G CGH TQ++WA+++ +GC    C+  +P  +N      CQY   GNI G+  Y+ G SCS CP  Y
Sbjct:   80 LTVLLSASIVCPLPTDVERAQMLEAHLVVREKVYPPASNMLLMEYSSELEALADRWASRCKFEHP--DDRYYPEYKGLGQNIALVGGAKP----SFTEAVCGWKDEVKDYDYFSGTCNGVCGHYTQMVWASSNLVGCAMRQCDYMEPSWSNPQYFTVCQYKPAGNIYGEKPYEYGASCSKCPDGY 258

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BLAST of Cysteine-rich venom protein vs. TrEMBL
Match: A0A0R3ST83 (SCP domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS8581 PE=3 SV=1)

HSP 1 Score: 126.716 bits (317), Expect = 3.095e-31
Identity = 70/203 (34.48%), Postives = 106/203 (52.22%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMVNPTATNMIKL------------------------QWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPS-SCTGTCGHATQILWATTSSIGCGRATCN----ATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            L D+E+  +L+ HN  RS+V+P+A+NM+++                         +N TLE+LA+ W + CV++HP   +  YS YGQNL + T     +  ++   V  W KE   + Y + +C+ TCGH TQ++WA +  IGC   TC      +    +   I CQY   GN +GQ  Y++G  CS+CP+ Y  C N LC
Sbjct:   19 LNDTERTQILSDHNGFRSIVSPSASNMLQMVTVLLSVASAIYLQACLFYYILLQSYNTTLESLAQKWVNYCVWKHPGTSDVEYSGYGQNLGMTTA----SSLNLQTIVDMWDKEKADYTYSTNTCSKTCGHYTQVVWAKSLQIGCAYQTCTNFSIGSKTYPKAFFIACQYSPPGNYIGQKPYENGTPCSHCPSGYESCVNNLC 217

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BLAST of Cysteine-rich venom protein vs. TrEMBL
Match: A0A210PN75 (Peptidase inhibitor 16 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT14275 PE=3 SV=1)

HSP 1 Score: 120.168 bits (300), Expect = 1.712e-29
Identity = 62/181 (34.25%), Postives = 105/181 (58.01%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPA--EDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPS-SCTGTCGHATQILWATTSSIGCGRATCNATDPNNE----NILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            L++ +KQ +++ HN+ RS V+P A NM+K+ W+  L  +A++++  CV+ H A   D  ++S  G+NL+L +       Y+ +  V +W+ E + + Y +  CT  CGH TQ++W  +  +GCG A CN+    +     ++++ C Y   GN  G T Y  G SCS+CP+    C+N+LC
Sbjct:   53 LSEGQKQDLVDYHNKARSEVSPRAANMLKMSWSNELATVAQSYAERCVWSHNAARSDAPSFSYVGENLFLTS-----GTYNGEGVVDSWVSEVKNYNYATLGCTSVCGHYTQVVWHDSEFVGCGAARCNSVSGLSSGWTNSVIVVCNYGKGGNYRGATPYTQGKSCSSCPSGKV-CQNRLC 227

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BLAST of Cysteine-rich venom protein vs. TrEMBL
Match: A0A0R3WJL8 (SCP domain-containing protein OS=Hydatigena taeniaeformis OX=6205 GN=TTAC_LOCUS874 PE=3 SV=1)

HSP 1 Score: 119.398 bits (298), Expect = 2.135e-29
Identity = 73/195 (37.44%), Postives = 106/195 (54.36%), Query Frame = 1

Query:    1 LIFTVFFHFQIVDPLLTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHP-AEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPS-SCT-GT-CGHATQILWATTSSIGCGRATCNATDPN--NENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            LI T+     +     T+ E++ +L+ HN  R+ VNP+ATNM+++ ++  LE LA +W + C F+HP +     Y+  GQNL L          ++      W  E  G+ Y S +CT GT CGH  Q++WAT+  +GC    C++  PN  +   L+TCQY   GN +G   Y SG+SCS CP     C NKLC
Sbjct:    4 LICTLLLVSLVASEAPTEQERKDLLDFHNNKRATVNPSATNMLEMVYSAELEKLAIDWVAKCKFEHPNSSQYPQYNGIGQNLALTGG----VGRNLVSQATQWWNEVSGYTYGSNACTVGTVCGHYIQMVWATSEELGCAVKQCDSLMPNWPSPVFLLTCQYKPAGNYIGIRPYTSGISCSQCPVG-TTCVNKLC 193

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BLAST of Cysteine-rich venom protein vs. Ensembl Cavefish
Match: ENSAMXT00000031557.1 (peptidase inhibitor 16 [Source:NCBI gene;Acc:103029846])

HSP 1 Score: 107.842 bits (268), Expect = 4.081e-28
Identity = 57/178 (32.02%), Postives = 95/178 (53.37%), Query Frame = 1

Query:   55 SEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQH-PAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSSCTGT---CGHATQILWATTSSIGCGRATCNATDP---NNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
             ++Q ++N+HN +RS V P A +MI ++W+  L  +A+ +++ C+++H P   N      G+NL++ T      P D++ A+  W  E + + Y ++       CGH TQ++WA T  +GCG   C   +     N  +L+ C Y   GN +GQ  YQ G  CS CP    +C ++ C
Sbjct:   28 EDQQRIVNLHNHHRSTVEPPAADMIHMKWSGELALIAKEYATKCIWEHNPDSQNIM----GENLFITT-----GPLDIEKALSDWFMEHKHYSYDNNTCAENEMCGHYTQMVWAKTKEVGCGSHLCETVEALGFKNATLLV-CNYLPLGNYMGQKPYQVGEQCSKCPDDLKNCVDQAC 195

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BLAST of Cysteine-rich venom protein vs. Ensembl Cavefish
Match: ENSAMXT00000036030.1 (peptidase inhibitor 16 [Source:NCBI gene;Acc:103029846])

HSP 1 Score: 107.071 bits (266), Expect = 6.513e-28
Identity = 57/178 (32.02%), Postives = 95/178 (53.37%), Query Frame = 1

Query:   55 SEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQH-PAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSSCTGT---CGHATQILWATTSSIGCGRATCNATDP---NNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
             ++Q ++N+HN +RS V P A +MI ++W+  L  +A+ +++ C+++H P   N      G+NL++ T      P D++ A+  W  E + + Y ++       CGH TQ++WA T  +GCG   C   +     N  +L+ C Y   GN +GQ  YQ G  CS CP    +C ++ C
Sbjct:   28 EDQQRIVNLHNHHRSTVEPPAADMIHMKWSGELALIAKEYATKCIWEHNPDSQNIM----GENLFITT-----GPLDIEKALSDWFMEHKHYSYDNNTCAENEMCGHYTQMVWAKTKEVGCGSHLCETVEALGFKNATLLV-CNYLPLGNYMGQKPYQVGEQCSKCPDDLKNCVDQAC 195

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BLAST of Cysteine-rich venom protein vs. Ensembl Cavefish
Match: ENSAMXT00000029824.1 (peptidase inhibitor 16 [Source:NCBI gene;Acc:103029846])

HSP 1 Score: 107.071 bits (266), Expect = 1.326e-27
Identity = 57/178 (32.02%), Postives = 95/178 (53.37%), Query Frame = 1

Query:   55 SEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQH-PAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSSCTGT---CGHATQILWATTSSIGCGRATCNATDP---NNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
             ++Q ++N+HN +RS V P A +MI ++W+  L  +A+ +++ C+++H P   N      G+NL++ T      P D++ A+  W  E + + Y ++       CGH TQ++WA T  +GCG   C   +     N  +L+ C Y   GN +GQ  YQ G  CS CP    +C ++ C
Sbjct:   28 EDQQRIVNLHNHHRSTVEPPAADMIHMKWSGELALIAKEYATKCIWEHNPDSQNIM----GENLFITT-----GPLDIEKALSDWFMEHKHYSYDNNTCAENEMCGHYTQMVWAKTKEVGCGSHLCETVEALGFKNATLLV-CNYLPLGNYMGQKPYQVGEQCSKCPDDLKNCVDQAC 195

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BLAST of Cysteine-rich venom protein vs. Ensembl Cavefish
Match: r3hdml (R3H domain containing like [Source:NCBI gene;Acc:103046222])

HSP 1 Score: 103.219 bits (256), Expect = 2.116e-26
Identity = 61/178 (34.27%), Postives = 98/178 (55.06%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLAT-RPKSITPYDVDLAVLAWIKESQGFVYPSSCTGT-CGHATQILWATTSSIGCGRATCNAT----DPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENK 561
            ++  +  ++L  HN+ RS V P A NM  + W++ L   AE+W+S C++ H       Y   GQNL +++ R +S+    ++L V +W  E   F YP+ CTG+ C H TQ++WA+T+ IGC    C+          +  L+ C Y ++GN +G+  Y++G  CS CP+ Y    NK
Sbjct:   62 VSSRDMTALLEYHNRVRSQVFPPAANMEYMVWDERLAKSAESWASQCIWDHGPSHVMKY--MGQNLSISSGRYRSV----IEL-VRSWHDEKNSFSYPNRCTGSVCSHYTQMVWASTNRIGCAINRCSNMYVFGSTWKQATLLVCNYSIKGNWVGEAPYKTGKPCSACPSVYGGSCNK 232

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BLAST of Cysteine-rich venom protein vs. Ensembl Cavefish
Match: ENSAMXT00000032496.1 (pep primary_assembly:Astyanax_mexicanus-2.0:18:32321795:32342374:-1 gene:ENSAMXG00000031919.1 transcript:ENSAMXT00000032496.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 98.2117 bits (243), Expect = 1.310e-24
Identity = 59/175 (33.71%), Postives = 88/175 (50.29%), Query Frame = 1

Query:   55 SEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSY--GQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSSCTGT--CGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            S +  ++N+HN  R  V+P+ATNM+K+ W++     A+NW++ C   H         +Y  G+NL+ +T     T       V AW  E   +VYP+    T   GH TQ++W ++ S+GCG A C +      N    C Y+  GN  G   Y  G SC+ CP     C++KLC
Sbjct:   41 SVQDEIVNLHNVFRRGVSPSATNMLKMNWSREAAVSAQNWANTCSMVHGDPSTRMLGTYQMGENLFKSTGMVKWTS-----VVTAWHNEVANYVYPTGSANTQPIGHYTQVVWYSSYSVGCGAAKCGS------NYFYVCHYYRAGNFKGVAPYTQGQSCAACPGA---CDDKLC 201

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BLAST of Cysteine-rich venom protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000374.1 (pep scaffold:Pmarinus_7.0:GL476650:75849:87118:-1 gene:ENSPMAG00000000334.1 transcript:ENSPMAT00000000374.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 90.8929 bits (224), Expect = 1.157e-21
Identity = 57/192 (29.69%), Postives = 88/192 (45.83%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPS----------SCTG-TCGHATQILWATTSSIGCGRATC------NATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPY-PDCENKLC 567
            + D E++++   HN+ R+ V+P A +M  + W+  L  +AE W+  C + H   D     + GQNL +    +    Y V     AW  E + + YP           +C G  C H TQ++WA +  +GC   TC      +A  P    + + C Y  +GN +G+  Y+ G  CS CP  Y   C   LC
Sbjct:    1 IADDERRALTEYHNRLRASVHPQAADMEHMSWDWELAGMAEAWAKQCKWGHGPSDQ--LDAIGQNLAVYVGSERPLAYHVQ----AWFDEEEWYQYPEEKECSPECPHTCRGPICTHYTQLVWAESRRVGCAVHTCLDISVWDAVWPY--ALYLVCNYSPKGNWIGEAPYRQGTPCSRCPPRYGGSCRGGLC 184

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BLAST of Cysteine-rich venom protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002250.1 (pep scaffold:Pmarinus_7.0:GL477299:1626:22672:-1 gene:ENSPMAG00000002049.1 transcript:ENSPMAT00000002250.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 76.6406 bits (187), Expect = 9.219e-18
Identity = 55/179 (30.73%), Postives = 83/179 (46.37%), Query Frame = 1

Query:   79 IHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSS----------CTGT-CGHATQILWATTSSIGCGRATCNATDPNNE----NILITCQYWLRGNILGQTLYQSGVSCSNCPTPY-PDCENKLC 567
            +HN+ R  V+P ++NM  + W + L   A  +   C+     +  A     GQ  +L+ RP S         V AW  E++ + YP            C G  C H TQ++WATT+ +GC   TC   +   +     + + C Y  +GN +G + Y+SG +CS CP  Y   C N LC
Sbjct:    2 LHNKLRGEVHPPSSNMEYMAWVKKLIKEAARYPGRCLRL--MQPMAMIHFLGQPHWLSHRPPS-------FHVQAWYDEAKDYQYPYEQECNPWCPFRCNGAVCTHYTQLVWATTNRVGCAINTCYNMNVWGQIWEKAVYLVCNYSPKGNWIGLSPYKSGRACSECPPSYGGSCRNNLC 171

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BLAST of Cysteine-rich venom protein vs. Ensembl Sea Lamprey
Match: CRISP3 (cysteine rich secretory protein 3 [Source:HGNC Symbol;Acc:HGNC:16904])

HSP 1 Score: 75.485 bits (184), Expect = 9.314e-17
Identity = 51/174 (29.31%), Postives = 86/174 (49.43%), Query Frame = 1

Query:   70 MLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSY--GQNLYLATRPKSITPYDVDLAVLAWIKE--SQGFVYP--SSCTGTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQ--TLYQSGVSCSNCPTPYPDCENKLC 567
            ++++HN  R  V P+A NM+++ W +     A +W++ C F H  +     + +  G+N+++++      P+  + A+  W  E  S GF Y   S+ TG  GH TQ++W  +  +GC    C   +P     L  C Y   GN+  +    Y  G SC++CP    +C N LC
Sbjct:   47 IVDLHNDLRRNVTPSAGNMLQMMWKKEAYLNALSWANNCTFGHSPDARRKTTQWTCGENIFMSS-----APFTWNYAIRDWYNEVISPGFQYDVGSTTTGAVGHYTQLVWYNSFQLGCAVNYC-PKNPGVAKYLYVCHYCPMGNLNTRINRPYDLGTSCASCPK---NCVNNLC 211

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BLAST of Cysteine-rich venom protein vs. Ensembl Sea Lamprey
Match: CLEC18A (C-type lectin domain family 18 member A [Source:HGNC Symbol;Acc:HGNC:30388])

HSP 1 Score: 60.4622 bits (145), Expect = 4.433e-11
Identity = 47/169 (27.81%), Postives = 75/169 (44.38%), Query Frame = 1

Query:   58 EKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSL-CVFQHPAEDNAA-----------------YSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPS-SCT--GTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQTL 501
            E  ++ ++HN+ R+ V P+A NM K++W+ +L  +A  W+++ C     AE  +A                        + L   P   T +   LA  +W  E Q + Y    C    TC H TQ++WA+ S +GC +  C   DP +      C Y L GN +  +L
Sbjct:   49 EAFALESLHNKLRATVQPSAANMEKMEWDDSLAQVAHEWAAVACENPRAAEGTSAEIPEKPGIQGTGAGGRGGGQRRLGVNLHRAPHGATSFASVLA--SWFSEGQNYDYARPGCAHNRTCRHYTQMVWASASRVGCAKRWCR--DPGSRVEAFACVY-LPGNDVRLSL 212

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BLAST of Cysteine-rich venom protein vs. Ensembl Sea Lamprey
Match: CRISP2 (cysteine rich secretory protein 2 [Source:HGNC Symbol;Acc:HGNC:12024])

HSP 1 Score: 48.9062 bits (115), Expect = 8.018e-8
Identity = 38/118 (32.20%), Postives = 55/118 (46.61%), Query Frame = 1

Query:  232 GQNLYLATRPKSITPYDVDLAVLAWIKESQ--GFVYPS--SCTGTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQ--TLYQSGVSCSNCPTPYPDCENKLC 567
            G+N++LAT P S        AVL W  E++  GF++    +  G  GH TQ++W ++  +GC    C          +  C Y   GN+  +    Y  G  C +CP    DCEN LC
Sbjct:    2 GENIFLATAPLSWQD-----AVLDWYNEAEVPGFIFGKGPAAPGDIGHYTQVVWYSSFQLGCAVNYCPEAI---YKYVYVCHYCPAGNLNTRLSRPYNEGSPCRSCPN---DCENDLC 108

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BLAST of Cysteine-rich venom protein vs. Ensembl Yeast
Match: PRY2 (Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication [Source:SGD;Acc:S000001721])

HSP 1 Score: 58.151 bits (139), Expect = 1.239e-10
Identity = 43/146 (29.45%), Postives = 67/146 (45.89%), Query Frame = 1

Query:   67 SMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSS--YGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPS-SCTGTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQ 495
            SM+N HN  R++   T +    L W+ TL   A+N++      +    N  +S   YG+NL L         Y    +V AW  E   + Y +   + + GH TQ++W  TS +GCG  +C     +     I C Y   GN++G+
Sbjct:  195 SMVNEHNTKRALHKDTGS----LTWSDTLATYAQNYAD----SYDCSGNLVHSGGPYGENLALG--------YGTTGSVDAWYNEITSYDYSNPGFSESAGHFTQVVWKGTSEVGCGLKSCGGEWGD----YIICSYKAAGNVIGE 320

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BLAST of Cysteine-rich venom protein vs. Ensembl Yeast
Match: PRY3 (Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p [Source:SGD;Acc:S000003614])

HSP 1 Score: 51.6026 bits (122), Expect = 3.434e-8
Identity = 47/150 (31.33%), Postives = 67/150 (44.67%), Query Frame = 1

Query:   61 KQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSS----LCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPS-SCTGTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQ 495
            +  +LN HN+ R++   TA     L W+ TL   A+N++       V  H      +   YG+NL L         Y    AV AW  E   + Y +   + + GH TQ++W +T+ IGCG   C  T     N  I C Y   GN LG+
Sbjct:   26 ESDVLNEHNKFRALHVDTA----PLTWSDTLATYAQNYADQYDCSGVLTH------SDGPYGENLALG--------YTDTGAVDAWYGEISKYNYSNPGFSESTGHFTQVVWKSTAEIGCGYKYCGTT----WNNYIVCSYNPPGNYLGE 153

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BLAST of Cysteine-rich venom protein vs. Ensembl Yeast
Match: PRY1 (Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY2; may be involved in detoxification of hydrophobic compounds; PRY1 has a paralog, PRY2, that arose from the whole genome duplication [Source:SGD;Acc:S000003615])

HSP 1 Score: 48.1358 bits (113), Expect = 2.870e-7
Identity = 40/147 (27.21%), Postives = 61/147 (41.50%), Query Frame = 1

Query:   70 MLNIHNQNRSMVNPTATNMIKLQWNQTL----EALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPS-SCTGTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQ 495
            +L  HN+ R++   T      L W+ TL    +  A+N+       H          YG+NL L         YD   AV AW  E   + + +   +   GH TQ++W +T+ +GCG  TC     +     + C Y   GN  G+
Sbjct:  166 VLAEHNKKRALHKDTPA----LSWSDTLASYAQDYADNYDCSGTLTHSG------GPYGENLALG--------YDGPAAVDAWYNEISNYDFSNPGFSSNTGHFTQVVWKSTTQVGCGIKTCGGAWGD----YVICSYDPAGNYEGE 290

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BLAST of Cysteine-rich venom protein vs. Ensembl Nematostella
Match: EDO48881 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHM8])

HSP 1 Score: 45.8246 bits (107), Expect = 1.573e-6
Identity = 36/147 (24.49%), Postives = 67/147 (45.58%), Query Frame = 1

Query:   61 KQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVY--PSSCTGTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQ 495
            K  +L  HN  R+     A     L+WN  L + A++W+   + Q  A  +++   YG+++   +          D+    W  E   + +  P   T + GH TQ++WA ++ +G G+AT ++         +  +Y   GN++GQ
Sbjct:    3 KNDILKTHNDYRAQHGTKA-----LKWNARLASEAQSWAE-NLAQRNAIQHSSSREYGESIAYMSGAVLTGRKATDM----WYGEVDKYRFENPGFST-SSGHFTQVVWAGSTEMGAGKATSSSGAH-----FVVARYTPPGNVMGQ 133

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BLAST of Cysteine-rich venom protein vs. Ensembl Nematostella
Match: EDO49310 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RH92])

HSP 1 Score: 46.9802 bits (110), Expect = 2.727e-6
Identity = 37/142 (26.06%), Postives = 63/142 (44.37%), Query Frame = 1

Query:   13 VFFHFQIVDPLLTDSEKQS-MLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCV----FQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSSCTG-TCGHATQILWATTSSIGCGRATC 420
            V    + +  L  D + +S +L+IHN  R+M      N   L+W+  L   A+ W+         +H + ++  Y   G+N+   +       +D+  A+  W  ES+ + Y +     T GH TQI+W  T  +G G A  
Sbjct:  197 VRMDIKTLGALPVDEDTRSRILDIHNNYRAM-----HNAAPLRWSAALAKDAQAWAGKLAREGRLEHASREDRYYK--GENICRMSHH-----FDIGDALQIWYNESESYQYDNPGFALTTGHFTQIVWRGTREVGVGFAKS 326

[Close]

BLAST of Cysteine-rich venom protein vs. Ensembl Nematostella
Match: EDO44787 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUQ3])

HSP 1 Score: 45.8246 bits (107), Expect = 4.251e-6
Identity = 45/160 (28.12%), Postives = 64/160 (40.00%), Query Frame = 1

Query:   73 LNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNA---------AYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSSCT---GTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQTLYQSGV 516
            L  HN  R +++ TA     L WN  +   A  ++     +  AEDN          A +S G+NLY +      T    D AV AW  E + + Y           GH TQ++W  ++ +G G A             I  +Y   GNI GQ  Y + V
Sbjct:   90 LAAHNHKR-VLHGTA----GLSWNAQMAEEAAKYA-----KKLAEDNKDTTRVSLNHASTSDGENLYYSGTSSGHTARCTD-AVSAWYNEIKDYDYNDYTNHPGAMIGHFTQVVWKGSTQVGVGAAKVKVN--GMTRTFIVARYRAAGNIRGQRYYDANV 236

[Close]

BLAST of Cysteine-rich venom protein vs. Ensembl Nematostella
Match: EDO37114 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SGM4])

HSP 1 Score: 43.8986 bits (102), Expect = 9.681e-6
Identity = 41/150 (27.33%), Postives = 62/150 (41.33%), Query Frame = 1

Query:   73 LNIHNQNRSMVNPTATNMIKLQWNQTLEALAENW----SSLCVFQHPAEDNAAYSSYGQNLYLA----TRPKSITPYDVDLAVLAWIKESQGFVYPSSC-TGTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQ 495
            L  HN+ R           ++ W+ +L A A+ W    S    F+H   D A+ +S  Q   LA     +P +    D   A  AW  ES  + Y ++  +   GH TQ++W  T  +G G A     D       +  ++   GNI GQ
Sbjct:    6 LEAHNEYRKRHGAK-----EMTWSASLAADAQKWADKLSQTDAFKH---DYASINSKSQGENLAYFTPQKPNNTAIMD---AFDAWYDESSKYDYANAKFSKETGHFTQLVWKATQKMGIGTAKNAKGDKE----YVVARFSPAGNIKGQ 140

[Close]

BLAST of Cysteine-rich venom protein vs. Ensembl Medaka
Match: ENSORLT00000023160.2 (peptidase inhibitor 16 [Source:NCBI gene;Acc:101164782])

HSP 1 Score: 100.523 bits (249), Expect = 1.173e-24
Identity = 61/181 (33.70%), Postives = 93/181 (51.38%), Query Frame = 1

Query:   43 LLTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYP-SSC--TGTCGHATQILWATTSSIGCGRATCNAT---DPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            LLTD +++ ++ +HN  R  V+P+A  M+ L+W+  L+ +AE +++ C+++H    N      G+NL+  T        D+  AV  W  E   + Y  +SC     CGH TQ++WA T  +GC    CN     D NN + L+ C Y+  GN   +  Y  G  CS CP     C+N LC
Sbjct:   56 LLTDQQEEMLVELHNHYRGQVSPSAAAMLPLKWDGNLKLVAEGYAAKCIWEH----NTELEDTGENLFAGT-----GKLDLSEAVEKWFLERLDYSYENNSCDEDKMCGHYTQMVWADTHRVGCAVHFCNTIENLDWNNVSYLV-CNYFPAGNYDDERPYVEGDWCSRCPEDLDVCQNHLC 226

[Close]

BLAST of Cysteine-rich venom protein vs. Ensembl Medaka
Match: ENSORLT00000020676.2 (cysteine-rich venom protein pseudecin-like [Source:NCBI gene;Acc:101157728])

HSP 1 Score: 88.5817 bits (218), Expect = 3.946e-21
Identity = 54/176 (30.68%), Postives = 86/176 (48.86%), Query Frame = 1

Query:   61 KQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSY--GQNLYLATRP---KSITPYDVDLAVLAWIKESQGFVYPSSCTG--TCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            +  ++++HN  R  V P A +M+ + +++ L   A+ W   CV  H    +   + Y  G+NL+ +T P   KSI        + AW KE   F +P++ T     GH TQ++W ++  +GCG   C     +N   L  C Y+  GN      Y+ G  C++CP    DC +KLC
Sbjct:   16 QAEIVDVHNAFRRAVEPPAADMLMMSYSEELAVSAQAWVDKCVLDHGPPSSRMLNGYELGENLFYSTSPMLWKSI--------INAWYKEVSHFAFPNASTNGKPVGHYTQVVWNSSYKVGCGVTLC-----SNNIYLYGCHYYRAGNFKRWPPYKVGTPCASCPN---DCVDKLC 175

[Close]

BLAST of Cysteine-rich venom protein vs. Ensembl Medaka
Match: crispld2 (cysteine rich secretory protein LCCL domain containing 2 [Source:NCBI gene;Acc:101174090])

HSP 1 Score: 92.0485 bits (227), Expect = 4.044e-21
Identity = 61/188 (32.45%), Postives = 91/188 (48.40%), Query Frame = 1

Query:   55 SEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLA-TRPKSITPYDVDLAVLAWIKESQGFVY----------PSSCTG-TCGHATQILWATTSSIGCGRATCNATDPNNE----NILITCQYWLRGNILGQTLYQSGVSCSNCPTPY-PDCENKLC 567
            S+++ +L +HN+ RS V P+A NM  + W+  LE  A  W+  C ++H  +D     S GQNL +   R +S         V AW  E + + Y          P  C+G  C H TQ++WATT+ +GC    C   +   E     + + C Y  +GN +G+  Y+ G  CS CP  +   C N LC
Sbjct:   74 SDREEILLLHNKLRSSVYPSAANMEHMVWDDELERSATQWAEECRWEHGPQD--LLMSIGQNLAVHWGRYRSPA-----FHVQAWYDEVKDYTYPYPSECNPWCPERCSGPMCTHYTQLVWATTNRVGCAVHVCPKMNVWGEIWETAVYLVCNYSPKGNWIGEAPYRHGRPCSQCPPSFGGGCRNNLC 254

[Close]

BLAST of Cysteine-rich venom protein vs. Ensembl Medaka
Match: crispld1a (cysteine rich secretory protein LCCL domain containing 1 [Source:NCBI gene;Acc:101172850])

HSP 1 Score: 92.0485 bits (227), Expect = 4.437e-21
Identity = 63/194 (32.47%), Postives = 94/194 (48.45%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQH-PAEDNAAYSSYGQNL---YLATRPKSITPYDVDLAVLAWIKESQGFVYPS----------SCTG-TCGHATQILWATTSSIGCGRATCNATDPNNE----NILITCQYWLRGNILGQTLYQSGVSCSNCPTPY-PDCENKLC 567
            +TDS+ Q +L++HN+ R  V P A+NM  + W+  LE  AE W+  C+++H PA   +     GQNL   +   +P +         V AW  E + + +P            C+G  C H TQ++WAT+S IGC    C+  D   +     + + C Y  +GN  G   Y+ G  CS CP  Y   C + LC
Sbjct:   84 ITDSDAQLILDLHNKLRGQVYPPASNMEYMMWDTELERSAEEWAETCLWEHGPA---SLLPQIGQNLGAHWGRYQPPT-------FHVQAWYDEVKDYSFPYPQECNPYCPFRCSGPVCTHYTQLVWATSSRIGCAINLCHNMDVWGQIWAKAVYLVCNYSPKGNWWGHAPYKHGTPCSACPPSYGGGCRDNLC 267

[Close]

BLAST of Cysteine-rich venom protein vs. Ensembl Medaka
Match: crispld1a (cysteine rich secretory protein LCCL domain containing 1 [Source:NCBI gene;Acc:101172850])

HSP 1 Score: 91.2781 bits (225), Expect = 6.052e-21
Identity = 63/194 (32.47%), Postives = 94/194 (48.45%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQH-PAEDNAAYSSYGQNL---YLATRPKSITPYDVDLAVLAWIKESQGFVYPS----------SCTG-TCGHATQILWATTSSIGCGRATCNATDPNNE----NILITCQYWLRGNILGQTLYQSGVSCSNCPTPY-PDCENKLC 567
            +TDS+ Q +L++HN+ R  V P A+NM  + W+  LE  AE W+  C+++H PA   +     GQNL   +   +P +         V AW  E + + +P            C+G  C H TQ++WAT+S IGC    C+  D   +     + + C Y  +GN  G   Y+ G  CS CP  Y   C + LC
Sbjct:   56 ITDSDAQLILDLHNKLRGQVYPPASNMEYMMWDTELERSAEEWAETCLWEHGPA---SLLPQIGQNLGAHWGRYQPPT-------FHVQAWYDEVKDYSFPYPQECNPYCPFRCSGPVCTHYTQLVWATSSRIGCAINLCHNMDVWGQIWAKAVYLVCNYSPKGNWWGHAPYKHGTPCSACPPSYGGGCRDNLC 239

[Close]

BLAST of Cysteine-rich venom protein vs. Planmine SMEST
Match: SMESG000044051.1 (SMESG000044051.1)

HSP 1 Score: 401.749 bits (1031), Expect = 2.600e-144
Identity = 209/209 (100.00%), Postives = 209/209 (100.00%), Query Frame = 1

Query:   70 MLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSSCTGTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLCXXXXXXXXXXXXXXXXPRNYTPKHVFHKFLNLLLFWIAILSRQ 696
            MLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSSCTGTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLCTKSIASGTISIISGTTPRNYTPKHVFHKFLNLLLFWIAILSRQ
Sbjct:    1 MLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSSCTGTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLCTKSIASGTISIISGTTPRNYTPKHVFHKFLNLLLFWIAILSRQ 209

[Close]

BLAST of Cysteine-rich venom protein vs. Planmine SMEST
Match: SMESG000044056.1 (SMESG000044056.1)

HSP 1 Score: 165.236 bits (417), Expect = 6.818e-51
Identity = 80/189 (42.33%), Postives = 109/189 (57.67%), Query Frame = 1

Query:   13 VFF--HFQIVDPLLTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNL-YLATRPKSITPYDVDLAVLAWIKESQGFVYPSSCT-GTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            VFF   FQ+    L+D E   M+  HN NRS V P ATNM + +W+  L  LA+ WS  C+++HP EDN  Y+ YGQNL Y  T P ++     + AV++W +E Q F YP +C+ G CGH TQ +WA T  +GCG+A C         + +TCQY+ RGN      Y++G  CS CP  +  C+  LC
Sbjct:    8 VFFMIQFQMRKSQLSDDEITKMIQYHNDNRSTVKPPATNMREFKWSNKLARLADKWSKQCIWEHPKEDNKEYAPYGQNLYYYETSPDALG--TAEKAVISWSEEIQYFTYPITCSGGVCGHYTQNIWADTYEVGCGKAICKGQSAATSKLFVTCQYYPRGNYKDTAPYETGTPCSKCPETHKVCKKNLC 194

[Close]

BLAST of Cysteine-rich venom protein vs. Planmine SMEST
Match: SMESG000044056.1 (SMESG000044056.1)

HSP 1 Score: 163.696 bits (413), Expect = 1.964e-50
Identity = 77/186 (41.40%), Postives = 106/186 (56.99%), Query Frame = 1

Query:   16 FFHFQIVDPLLTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNL-YLATRPKSITPYDVDLAVLAWIKESQGFVYPSSCT-GTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
               FQ+    L+D E   M+  HN NRS V P ATNM + +W+  L  LA+ WS  C+++HP EDN  Y+ YGQNL Y  T P ++     + AV++W +E Q F YP +C+ G CGH TQ +WA T  +GCG+A C         + +TCQY+ RGN      Y++G  CS CP  +  C+  LC
Sbjct:    1 MIQFQMRKSQLSDDEITKMIQYHNDNRSTVKPPATNMREFKWSNKLARLADKWSKQCIWEHPKEDNKEYAPYGQNLYYYETSPDALG--TAEKAVISWSEEIQYFTYPITCSGGVCGHYTQNIWADTYEVGCGKAICKGQSAATSKLFVTCQYYPRGNYKDTAPYETGTPCSKCPETHKVCKKNLC 184

[Close]

BLAST of Cysteine-rich venom protein vs. Planmine SMEST
Match: SMESG000044056.1 (SMESG000044056.1)

HSP 1 Score: 159.844 bits (403), Expect = 5.669e-49
Identity = 75/176 (42.61%), Postives = 103/176 (58.52%), Query Frame = 1

Query:   46 LTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNL-YLATRPKSITPYDVDLAVLAWIKESQGFVYPSSCT-GTCGHATQILWATTSSIGCGRATCNATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            L+D E   M+  HN NRS V P ATNM + +W+  L  LA+ WS  C+++HP EDN  Y+ YGQNL Y  T P ++     + AV++W +E Q F YP +C+ G CGH TQ +WA T  +GCG+A C         + +TCQY+ RGN      Y++G  CS CP  +  C+  LC
Sbjct:    6 LSDDEITKMIQYHNDNRSTVKPPATNMREFKWSNKLARLADKWSKQCIWEHPKEDNKEYAPYGQNLYYYETSPDALG--TAEKAVISWSEEIQYFTYPITCSGGVCGHYTQNIWADTYEVGCGKAICKGQSAATSKLFVTCQYYPRGNYKDTAPYETGTPCSKCPETHKVCKKNLC 179

[Close]

BLAST of Cysteine-rich venom protein vs. Planmine SMEST
Match: SMESG000044061.1 (SMESG000044061.1)

HSP 1 Score: 148.288 bits (373), Expect = 2.964e-44
Identity = 75/192 (39.06%), Postives = 111/192 (57.81%), Query Frame = 1

Query:    1 LIFTVFFHFQIVDPLLTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQTLEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVLAWIKESQGFVYPSSCTGTCGHATQILWATTSSIGCGRATC---NATDPNNENILITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLC 567
            +IF ++F  +  + LL  +E++ +LN+HN  R+ V P ++NM K+ WNQTL  LA N S  C    P ++N+ +S YG N+Y +   KS T  D+     +W+ E + F+YP  CTG C + TQI+W++++ +GC    C   N++     NI +TC YW +GNI G   Y SG  CS CP     C  KLC
Sbjct:    1 MIFAIYF--RNGNFLLNKNERKLILNLHNNYRNNVKPQSSNMTKMTWNQTLYNLALNISWNCSLDFPGKNNSEFSEYGINMYFSIMSKS-TVKDIHKTFESWVSEEKNFMYPFKCTGNCMNYTQIVWSSSTQLGCNDNMCFMKNSSKIRKWNIFLTCLYWPKGNIFGMVPYGSGKPCSKCPKKMAYCVYKLC 189

The following BLAST results are available for this feature:

BLAST of Cysteine-rich venom protein vs. Ensembl Human
BLAST of Cysteine-rich venom protein vs. Ensembl Celegans
BLAST of Cysteine-rich venom protein vs. Ensembl Fly
BLAST of Cysteine-rich venom protein vs. Ensembl Zebrafish
BLAST of Cysteine-rich venom protein vs. Ensembl Xenopus
BLAST of Cysteine-rich venom protein vs. Ensembl Mouse
BLAST of Cysteine-rich venom protein vs. UniProt/SwissProt
BLAST of Cysteine-rich venom protein vs. TrEMBL
BLAST of Cysteine-rich venom protein vs. Ensembl Cavefish
BLAST of Cysteine-rich venom protein vs. Ensembl Sea Lamprey
BLAST of Cysteine-rich venom protein vs. Ensembl Yeast
BLAST of Cysteine-rich venom protein vs. Ensembl Nematostella
BLAST of Cysteine-rich venom protein vs. Ensembl Medaka
BLAST of Cysteine-rich venom protein vs. Planmine SMEST

BLAST of Cysteine-rich venom protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PI16	2.765e-29	37.43	peptidase inhibitor 16 [Source:HGNC Symbol;Acc:HGN...	[more]
PI16	2.765e-29	37.43	peptidase inhibitor 16 [Source:HGNC Symbol;Acc:HGN...	[more]
PI16	2.765e-29	37.43	peptidase inhibitor 16 [Source:HGNC Symbol;Acc:HGN...	[more]
CRISP2	2.771e-26	34.46	cysteine rich secretory protein 2 [Source:HGNC Sym...	[more]
CRISP2	2.771e-26	34.46	cysteine rich secretory protein 2 [Source:HGNC Sym...	[more]

BLAST of Cysteine-rich venom protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
scl-7	8.058e-27	35.08	SCP-Like extracellular protein [Source:UniProtKB/...	[more]
scl-8	1.188e-25	34.38	SCP-Like extracellular protein [Source:UniProtKB/...	[more]
scl-1	2.817e-23	32.00	SCP-Like extracellular protein [Source:UniProtKB/...	[more]
scl-10	3.568e-23	32.37	SCP-Like extracellular protein [Source:UniProtKB/...	[more]
scl-5	6.858e-22	32.97	SCP-Like extracellular protein [Source:UniProtKB/...	[more]

BLAST of Cysteine-rich venom protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CG8483	5.892e-18	30.11	gene:FBgn0038126 transcript:FBtr0082782	[more]
CG9400	5.109e-9	25.00	gene:FBgn0030562 transcript:FBtr0073920	[more]
CG32679	2.409e-7	26.40	gene:FBgn0052679 transcript:FBtr0071469	[more]
Ag5r	9.012e-6	26.92	gene:FBgn0015010 transcript:FBtr0333658	[more]
Ag5r	9.012e-6	26.92	gene:FBgn0015010 transcript:FBtr0073937	[more]

BLAST of Cysteine-rich venom protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
r3hdml	2.687e-26	34.64	R3H domain containing-like [Source:ZFIN;Acc:ZDB-GE...	[more]
r3hdml	2.687e-26	34.64	R3H domain containing-like [Source:ZFIN;Acc:ZDB-GE...	[more]
glipr1a	4.396e-26	31.68	GLI pathogenesis-related 1a [Source:ZFIN;Acc:ZDB-G...	[more]
glipr1a	1.395e-25	31.68	GLI pathogenesis-related 1a [Source:ZFIN;Acc:ZDB-G...	[more]
crispld2	3.330e-22	32.62	cysteine-rich secretory protein LCCL domain contai...	[more]

BLAST of Cysteine-rich venom protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSXETT00000036788.1	5.434e-24	33.52	pep primary_assembly:Xenopus_tropicalis_v9.1:KV464...	[more]
crispld2	1.641e-23	32.09	cysteine-rich secretory protein LCCL domain contai...	[more]
crispld2	1.736e-23	32.09	cysteine-rich secretory protein LCCL domain contai...	[more]
crispld2	1.904e-23	32.09	cysteine-rich secretory protein LCCL domain contai...	[more]
stn1	9.213e-22	34.44	STN1, CST complex subunit [Source:Xenbase;Acc:XB-G...	[more]

BLAST of Cysteine-rich venom protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Pi16	3.040e-31	37.43	peptidase inhibitor 16 [Source:MGI Symbol;Acc:MGI:...	[more]
Pi16	3.288e-31	37.43	peptidase inhibitor 16 [Source:MGI Symbol;Acc:MGI:...	[more]
Pi16	3.288e-31	37.43	peptidase inhibitor 16 [Source:MGI Symbol;Acc:MGI:...	[more]
Pi16	3.510e-30	37.43	peptidase inhibitor 16 [Source:MGI Symbol;Acc:MGI:...	[more]
Glipr1l1	1.078e-24	36.51	GLI pathogenesis-related 1 like 1 [Source:MGI Symb...	[more]

BLAST of Cysteine-rich venom protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9ET66\|PI16_MOUSE	2.455e-29	37.43	Peptidase inhibitor 16 OS=Mus musculus OX=10090 GN...	[more]
sp\|Q6UXB8\|PI16_HUMAN	1.328e-28	37.43	Peptidase inhibitor 16 OS=Homo sapiens OX=9606 GN=...	[more]
sp\|Q58D34\|PI16_BOVIN	1.563e-27	37.64	Peptidase inhibitor 16 OS=Bos taurus OX=9913 GN=PI...	[more]
sp\|P16562\|CRIS2_HUMAN	1.331e-25	34.46	Cysteine-rich secretory protein 2 OS=Homo sapiens ...	[more]
sp\|Q8JI39\|CRVP_PROFL	9.516e-25	35.39	Cysteine-rich venom protein triflin OS=Protobothro...	[more]

BLAST of Cysteine-rich venom protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A564YKT8	2.511e-36	39.11	SCP domain-containing protein (Fragment) OS=Hymeno...	[more]
A0A0R3WLM2	7.695e-32	38.92	SCP domain-containing protein OS=Hydatigena taenia...	[more]
A0A0R3ST83	3.095e-31	34.48	SCP domain-containing protein OS=Hymenolepis dimin...	[more]
A0A210PN75	1.712e-29	34.25	Peptidase inhibitor 16 OS=Mizuhopecten yessoensis ...	[more]
A0A0R3WJL8	2.135e-29	37.44	SCP domain-containing protein OS=Hydatigena taenia...	[more]

BLAST of Cysteine-rich venom protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSAMXT00000031557.1	4.081e-28	32.02	peptidase inhibitor 16 [Source:NCBI gene;Acc:10302...	[more]
ENSAMXT00000036030.1	6.513e-28	32.02	peptidase inhibitor 16 [Source:NCBI gene;Acc:10302...	[more]
ENSAMXT00000029824.1	1.326e-27	32.02	peptidase inhibitor 16 [Source:NCBI gene;Acc:10302...	[more]
r3hdml	2.116e-26	34.27	R3H domain containing like [Source:NCBI gene;Acc:1...	[more]
ENSAMXT00000032496.1	1.310e-24	33.71	pep primary_assembly:Astyanax_mexicanus-2.0:18:323...	[more]

BLAST of Cysteine-rich venom protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000000374.1	1.157e-21	29.69	pep scaffold:Pmarinus_7.0:GL476650:75849:87118:-1 ...	[more]
ENSPMAT00000002250.1	9.219e-18	30.73	pep scaffold:Pmarinus_7.0:GL477299:1626:22672:-1 g...	[more]
CRISP3	9.314e-17	29.31	cysteine rich secretory protein 3 [Source:HGNC Sym...	[more]
CLEC18A	4.433e-11	27.81	C-type lectin domain family 18 member A [Source:HG...	[more]
CRISP2	8.018e-8	32.20	cysteine rich secretory protein 2 [Source:HGNC Sym...	[more]

BLAST of Cysteine-rich venom protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 3


Match Name	E-value	Identity	Description
PRY2	1.239e-10	29.45	Sterol binding protein involved in the export of a...	[more]
PRY3	3.434e-8	31.33	Cell wall-associated protein involved in export of...	[more]
PRY1	2.870e-7	27.21	Sterol binding protein involved in the export of a...	[more]

BLAST of Cysteine-rich venom protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 4


Match Name	E-value	Identity	Description
EDO48881	1.573e-6	24.49	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49310	2.727e-6	26.06	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO44787	4.251e-6	28.13	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37114	9.681e-6	27.33	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Cysteine-rich venom protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSORLT00000023160.2	1.173e-24	33.70	peptidase inhibitor 16 [Source:NCBI gene;Acc:10116...	[more]
ENSORLT00000020676.2	3.946e-21	30.68	cysteine-rich venom protein pseudecin-like [Source...	[more]
crispld2	4.044e-21	32.45	cysteine rich secretory protein LCCL domain contai...	[more]
crispld1a	4.437e-21	32.47	cysteine rich secretory protein LCCL domain contai...	[more]
crispld1a	6.052e-21	32.47	cysteine rich secretory protein LCCL domain contai...	[more]

BLAST of Cysteine-rich venom protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000044051.1	2.600e-144	100.00	SMESG000044051.1	[more]
SMESG000044056.1	6.818e-51	42.33	SMESG000044056.1	[more]
SMESG000044056.1	1.964e-50	41.40	SMESG000044056.1	[more]
SMESG000044056.1	5.669e-49	42.61	SMESG000044056.1	[more]
SMESG000044061.1	2.964e-44	39.06	SMESG000044061.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30024253 ID=SMED30024253|Name=Cysteine-rich venom protein|organism=Schmidtea mediterranea sexual|type=transcript|length=698bp
TTAATTTTTACTGTTTTCTTTCACTTCCAAATTGTTGATCCTTTATTAAC
GGATTCTGAAAAACAATCAATGCTAAACATACATAATCAGAATCGAAGTA
TGGTCAATCCAACCGCAACCAATATGATAAAACTACAATGGAATCAAACT
CTTGAAGCATTGGCAGAAAACTGGAGTTCTCTGTGCGTATTTCAGCACCC
AGCCGAGGACAATGCTGCTTATTCTAGTTATGGGCAAAACCTGTACTTAG
CAACTCGACCTAAATCCATTACTCCATATGATGTAGATTTGGCCGTTTTA
GCCTGGATTAAAGAATCTCAAGGCTTTGTTTATCCCTCTTCCTGCACTGG
GACTTGTGGTCACGCTACTCAAATACTTTGGGCAACAACCTCCAGTATTG
GCTGCGGCAGAGCGACTTGCAATGCTACTGATCCTAATAATGAGAATATC
TTGATAACCTGCCAATATTGGCTCAGAGGAAATATTTTAGGACAAACACT
TTATCAAAGTGGAGTATCATGTTCGAATTGCCCAACACCATATCCTGATT
GTGAGAATAAGCTTTGCACTAAGTCCATCGCGTCTGGGACTATTTCTATT
ATATCTGGAACTACACCAAGAAATTATACACCAAAACATGTATTTCATAA
ATTTTTGAATCTTCTCTTATTTTGGATAGCTATTTTATCTAGACAACC

protein sequence of SMED30024253-orf-1

>SMED30024253-orf-1 ID=SMED30024253-orf-1|Name=SMED30024253-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=232bp
LIFTVFFHFQIVDPLLTDSEKQSMLNIHNQNRSMVNPTATNMIKLQWNQT
LEALAENWSSLCVFQHPAEDNAAYSSYGQNLYLATRPKSITPYDVDLAVL
AWIKESQGFVYPSSCTGTCGHATQILWATTSSIGCGRATCNATDPNNENI
LITCQYWLRGNILGQTLYQSGVSCSNCPTPYPDCENKLCTKSIASGTISI
ISGTTPRNYTPKHVFHKFLNLLLFWIAILSRQ

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0090729	toxin activity

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000418	head
PLANA:0002089	reproductive organ

Vocabulary: **INTERPRO**
Term	Definition
IPR035940	CAP_sf
IPR001283	CRISP-related
IPR014044	CAP_domain

Vocabulary: **cellular component**
Term	Definition
GO:0005576	extracellular region

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 226..232
None	No IPR available	PANTHER	PTHR10334:SF344	AT27079P-RELATED	coord: 16..187
None	No IPR available	CDD	cd05380	CAP_euk	coord: 21..157 e-value: 1.44263E-34 score: 118.711
IPR001283	Cysteine-rich secretory protein-related	PRINTS	PR00837	V5TPXLIKE	coord: 98..111 score: 32.48 coord: 119..135 score: 52.01 coord: 151..164 score: 39.32 coord: 45..63 score: 28.53
IPR001283	Cysteine-rich secretory protein-related	PANTHER	PTHR10334	CYSTEINE-RICH SECRETORY PROTEIN-RELATED	coord: 16..187
IPR014044	CAP domain	SMART	SM00198	SCP_3	coord: 19..164 e-value: 3.5E-41 score: 152.8
IPR014044	CAP domain	PFAM	PF00188	CAP	coord: 25..156 e-value: 1.5E-18 score: 67.8
IPR035940	CAP superfamily	GENE3D	G3DSA:3.40.33.10		coord: 8..197 e-value: 2.2E-48 score: 166.4
IPR035940	CAP superfamily	SUPERFAMILY	SSF55797	PR-1-like	coord: 15..171