Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Overview
NameEvolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
Smed IDSMED30024207
Length (bp)1319
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (SMED30024207) t-SNE clustered cells

Violin plots show distribution of expression levels for Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (SMED30024207) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (SMED30024207) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (SMED30024207) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30024207

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
reproductive organSMED30024207h1SMcG0001086 Contig24983newmark_estsPMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
reproductive organSMED30024207h1SMcG0001086 Contig24983uc_Smed_v2PMID:28434803
Rouhana et al., 2017		whole organism adult hermaphrodite RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Human
Match: ECSIT (ECSIT signaling integrator [Source:HGNC Symbol;Acc:HGNC:29548])

HSP 1 Score: 159.073 bits (401), Expect = 2.392e-43
Identity = 96/327 (29.36%), Postives = 164/327 (50.15%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMI-------NDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRA-----------IYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRV 1263
            +RGH++F+   L+KM+ + V R+L +Y ++L+IFP+    P++I Q    HYP+QQ+C I +L  ME +G++P+++   +L + FG  + P+ +  R+  W P+  N+NP+PVP+DLP DP E+A   L  + P    RV I +V +        D  +  IV  QS  Q+        +L   N  R V+V+GP+++W+RN+ V Y +L +DL                +YY    + + +     +DN+   FD N                         E+E   + A C+   ++ +++  W+  + + NP L    VVFR+
Sbjct:  103 KRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSARVTIYQVPLPKDSTGAADPPQPHIVGIQSPDQQA-------ALARHNPARPVFVEGPFSLWLRNKCVYYHILRADLLPPEEREVEETPEEWNLYYPMQLDLEYVRSG--WDNYE--FDIN-------------------------EVEEGPVFAMCMAGAHDQATMAKWIQGLQETNPTLAQIPVVFRL 393
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Human
Match: ECSIT (ECSIT signaling integrator [Source:HGNC Symbol;Acc:HGNC:29548])

HSP 1 Score: 137.117 bits (344), Expect = 2.803e-37
Identity = 71/200 (35.50%), Postives = 116/200 (58.00%), Query Frame = 1 
Query:  379 MKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMI-------NDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDL 957
            M+ + V R+L +Y ++L+IFP+    P++I Q    HYP+QQ+C I +L  ME +G++P+++   +L + FG  + P+ +  R+  W P+  N+NP+PVP+DLP DP E+A   L  + P    RV I +V +        D  +  IV  QS  Q+        +L   N  R V+V+GP+++W+RN+ V Y +L +DL
Sbjct:    1 MREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSARVTIYQVPLPKDSTGAADPPQPHIVGIQSPDQQA-------ALARHNPARPVFVEGPFSLWLRNKCVYYHILRADL 193
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Human
Match: ECSIT (ECSIT signaling integrator [Source:HGNC Symbol;Acc:HGNC:29548])

HSP 1 Score: 124.02 bits (310), Expect = 1.012e-31
Identity = 56/145 (38.62%), Postives = 93/145 (64.14%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEV 771
            +RGH++F+   L+KM+ + V R+L +Y ++L+IFP+    P++I Q    HYP+QQ+C I +L  ME +G++P+++   +L + FG  + P+ +  R+  W P+  N+NP+PVP+DLP DP E+A   L  + P    RV I +V
Sbjct:  103 KRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSARVTIYQV 247
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Human
Match: ECSIT (ECSIT signaling integrator [Source:HGNC Symbol;Acc:HGNC:29548])

HSP 1 Score: 124.02 bits (310), Expect = 1.166e-31
Identity = 56/145 (38.62%), Postives = 93/145 (64.14%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEV 771
            +RGH++F+   L+KM+ + V R+L +Y ++L+IFP+    P++I Q    HYP+QQ+C I +L  ME +G++P+++   +L + FG  + P+ +  R+  W P+  N+NP+PVP+DLP DP E+A   L  + P    RV I +V
Sbjct:  103 KRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSARVTIYQV 247
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Human
Match: ECSIT (ECSIT signaling integrator [Source:HGNC Symbol;Acc:HGNC:29548])

HSP 1 Score: 115.931 bits (289), Expect = 1.995e-29
Identity = 50/125 (40.00%), Postives = 85/125 (68.00%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVA 711
            +RGH++F+   L+KM+ + V R+L +Y ++L+IFP+    P++I Q    HYP+QQ+C I +L  ME +G++P+++   +L + FG  + P+ +  R+  W P+  N+NP+PVP+DLP DP E+A
Sbjct:  103 KRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELA 227
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Celegans
Match: Y17G9B.5 (pep chromosome:WBcel235:IV:4750240:4751491:1 gene:WBGene00021202.1 transcript:Y17G9B.5.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y17G9B.5)

HSP 1 Score: 145.976 bits (367), Expect = 1.219e-39
Identity = 102/341 (29.91%), Postives = 189/341 (55.43%), Query Frame = 1 
Query:  295 EEAILAYLMKYGSSR-RGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPN---DPSEVARIALTRLNPIRDTRVNINEVMINDHD---KTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILA-SCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDLVNK 1293
            ++A +A +  +   R R HVEF+   LK +K + VH+++D YK +L++FP+ KMIP++++Q    HYP+QQ+CA+K+L  ME +G+ PD++   ++   FG       + +RMLYWMPK+K+ N Y   + +      PSE+A IAL  ++  RD   +I+ + ++D     + W+ ++QS  Q+ LIS L +   G+     V+VD    V+++++ + +  LT +        +K    N+ +++   Y NWY              D  +Q+   A+ +I+E + E  +I A   + +++N +++R W++ + K NP + + R  FRV L    ++++
Sbjct:   44 KDAFMAAIATFKEKRGRTHVEFINTALKYVKEYGVHKDIDTYKGLLEVFPKGKMIPQTVFQKVFLHYPQQQNCAVKVLDEMEWHGVQPDKEIHDIVVNAFGEWNFATKKVKRMLYWMPKLKHSNKYLDRRHVEGKSLSPSELAGIALKMMS--RDAASSISLLKLSDSSDPQQKWLATSQSPMQQILISELRK---GDE----VFVDAA-KVYLQDRVIPFITLTGNTKLEPLNEFK----NEDMDED--YTNWY-------------ADWQKQRG-EAKRSIHEQDHE--TIFAMGAMYKDDNATAIR-WIDNLQKTNPNMENLR--FRVRLEGNPIISR 349
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Fly
Match: ECSIT (gene:FBgn0028436 transcript:FBtr0078647)

HSP 1 Score: 199.134 bits (505), Expect = 5.436e-59
Identity = 111/313 (35.46%), Postives = 173/313 (55.27%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNI----NEVMINDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRV-IKENPELNDFRVVFR 1260
            RR HVEF+   LK M  F V R+L++YK ++++ P+ K IP +++QAE  HYPKQQ C I +L  ME+ G++PD +   ML   FG    P+ +Y RM+YWMPK KNL+P+P+P  +P+D  E+A++AL R+  + D R  I       + +  D TWIVS  S  Q+ L       L   ++++ +Y++GP+ +W+RN+R+NYF L +D D     +  +L E Q   D V +           E+P     P R+     +L     + +G +I+A C T  +   SL  W+  +    NP + +  V+FR
Sbjct:   83 RRNHVEFIYAALKNMADFGVERDLEVYKALINVMPKGKFIPTNMFQAEFMHYPKQQQCIIDLLEQMEDCGVMPDHEMEAMLLNVFGRQGHPLRKYWRMMYWMPKFKNLSPWPLPDPVPDDTLEMAKLALERMCTV-DLRSKITVFETSELKDAIDDTWIVSGMSPEQEKL-------LREHSRQKALYIEGPFHIWLRNRRINYFTLRADADSE---FLSELDERQLDEDDVSH----------IEVPFFGRAPPRRHNQLGKLRSVHQQDDG-TIMAICATGTSTKDSLLSWIRLLEANGNPSIGEVPVLFR 373
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Zebrafish
Match: ecsit (ECSIT signaling integrator [Source:NCBI gene;Acc:569243])

HSP 1 Score: 178.718 bits (452), Expect = 1.096e-50
Identity = 101/323 (31.27%), Postives = 171/323 (52.94%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMINDHDKTW-------IVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDL 1284
            RRGHVEF+   LKKM  F V  ++ +Y K+LD+FP+   +P++  Q    HYP+QQ+C +++L  ME  G++P+ +   +L + FG  + P+ ++QR++YW PK K+ NPYPVP  LP+DP ++A+ +LTR+    D ++ I +    D  +T        IV  QS  Q++L       L   N  + V+V+GPY +W+R + V+Y+LL +D         +++       ++  +       D N    V  GD         + +   DE+E  ++ A C+    + ++L  W++ + +  P L     VFR+  GP +L
Sbjct:  116 RRGHVEFIYAALKKMPEFGVECDVTVYNKLLDVFPKEVFVPQNFIQRMFNHYPRQQECGVQVLEQMENYGVMPNIETKVLLVQIFGEKSHPIRKFQRIMYWFPKFKHTNPYPVPHVLPSDPVDLAQFSLTRIAADLDAKITIYQYPSTDITETGEEITRPHIVGIQSPDQRSL-------LAKHNPCKPVFVEGPYPLWLRQKCVHYYLLRADPIPPEEKVEEEIDPEMICPEQSLFFPQRVELDLN----VDMGD---------DHSFNVDEVEEGAVYAMCMAGQGDQATLSQWISGLQETCPILGQIPTVFRLESGPREL 418
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Zebrafish
Match: ecsit (ECSIT signaling integrator [Source:NCBI gene;Acc:569243])

HSP 1 Score: 178.718 bits (452), Expect = 1.096e-50
Identity = 101/323 (31.27%), Postives = 171/323 (52.94%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMINDHDKTW-------IVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDL 1284
            RRGHVEF+   LKKM  F V  ++ +Y K+LD+FP+   +P++  Q    HYP+QQ+C +++L  ME  G++P+ +   +L + FG  + P+ ++QR++YW PK K+ NPYPVP  LP+DP ++A+ +LTR+    D ++ I +    D  +T        IV  QS  Q++L       L   N  + V+V+GPY +W+R + V+Y+LL +D         +++       ++  +       D N    V  GD         + +   DE+E  ++ A C+    + ++L  W++ + +  P L     VFR+  GP +L
Sbjct:  116 RRGHVEFIYAALKKMPEFGVECDVTVYNKLLDVFPKEVFVPQNFIQRMFNHYPRQQECGVQVLEQMENYGVMPNIETKVLLVQIFGEKSHPIRKFQRIMYWFPKFKHTNPYPVPHVLPSDPVDLAQFSLTRIAADLDAKITIYQYPSTDITETGEEITRPHIVGIQSPDQRSL-------LAKHNPCKPVFVEGPYPLWLRQKCVHYYLLRADPIPPEEKVEEEIDPEMICPEQSLFFPQRVELDLN----VDMGD---------DHSFNVDEVEEGAVYAMCMAGQGDQATLSQWISGLQETCPILGQIPTVFRLESGPREL 418
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Zebrafish
Match: ecsit (ECSIT signaling integrator [Source:NCBI gene;Acc:569243])

HSP 1 Score: 178.718 bits (452), Expect = 1.096e-50
Identity = 101/323 (31.27%), Postives = 171/323 (52.94%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMINDHDKTW-------IVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDL 1284
            RRGHVEF+   LKKM  F V  ++ +Y K+LD+FP+   +P++  Q    HYP+QQ+C +++L  ME  G++P+ +   +L + FG  + P+ ++QR++YW PK K+ NPYPVP  LP+DP ++A+ +LTR+    D ++ I +    D  +T        IV  QS  Q++L       L   N  + V+V+GPY +W+R + V+Y+LL +D         +++       ++  +       D N    V  GD         + +   DE+E  ++ A C+    + ++L  W++ + +  P L     VFR+  GP +L
Sbjct:  116 RRGHVEFIYAALKKMPEFGVECDVTVYNKLLDVFPKEVFVPQNFIQRMFNHYPRQQECGVQVLEQMENYGVMPNIETKVLLVQIFGEKSHPIRKFQRIMYWFPKFKHTNPYPVPHVLPSDPVDLAQFSLTRIAADLDAKITIYQYPSTDITETGEEITRPHIVGIQSPDQRSL-------LAKHNPCKPVFVEGPYPLWLRQKCVHYYLLRADPIPPEEKVEEEIDPEMICPEQSLFFPQRVELDLN----VDMGD---------DHSFNVDEVEEGAVYAMCMAGQGDQATLSQWISGLQETCPILGQIPTVFRLESGPREL 418
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Zebrafish
Match: ecsit (ECSIT signaling integrator [Source:NCBI gene;Acc:569243])

HSP 1 Score: 140.584 bits (353), Expect = 5.251e-38
Identity = 68/178 (38.20%), Postives = 110/178 (61.80%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMINDHDKTW-------IVSAQSKTQKTLISYLN 849
            RRGHVEF+   LKKM  F V  ++ +Y K+LD+FP+   +P++  Q    HYP+QQ+C +++L  ME  G++P+ +   +L + FG  + P+ ++QR++YW PK K+ NPYPVP  LP+DP ++A+ +LTR+    D ++ I +    D  +T        IV  QS  Q++L++  N
Sbjct:  116 RRGHVEFIYAALKKMPEFGVECDVTVYNKLLDVFPKEVFVPQNFIQRMFNHYPRQQECGVQVLEQMENYGVMPNIETKVLLVQIFGEKSHPIRKFQRIMYWFPKFKHTNPYPVPHVLPSDPVDLAQFSLTRIAADLDAKITIYQYPSTDITETGEEITRPHIVGIQSPDQRSLLAKHN 293
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Xenopus
Match: wars1 (tryptophanyl-tRNA synthetase 1 [Source:Xenbase;Acc:XB-GENE-954237])

HSP 1 Score: 175.252 bits (443), Expect = 1.397e-49
Identity = 103/323 (31.89%), Postives = 173/323 (53.56%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMIN-------DHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDL 1284
            RRGHVE +   L+ M  F V ++L++Y K+LD+FP+   +P++  Q    HYP+QQ+CAI++L  ME  G+ P++    +L + FG  + P+ +YQRM+YW P+ K+ NP+PVP +LP DP E++R+ L R+    D+RV + ++          + +   +V  QS +Q +L++  N S         VYV+GP+ +W+R   V Y++L +D D  R       +E +  N++  Y             P+   D    + L  + +   D++E   + A C+  + +   L  W+  + + NP L    VVFR+N GP +L
Sbjct:   89 RRGHVEIIEAALRWMTEFGVEKDLEVYNKLLDVFPKEVFVPQNYIQRMFNHYPRQQECAIRVLEQMENYGITPNKQTCFLLLQIFGARSHPIRKYQRMMYWFPRFKHTNPFPVPAELPADPVELSRMCLHRIANDLDSRVAVYQMPYTEKCDDGKEREHLHVVGIQSPSQVSLLAAHNPSTP-------VYVEGPFPLWLRKTCVYYYILRADPDPMR-------KEEEIDNERSLY------------YPLSL-DLELDRDLGDDDSFDVDDVEEGPVFAMCMAGSGDELLLGKWIRGLQETNPILGQTPVVFRLNSGPQEL 384
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Mouse
Match: Ecsit (ECSIT signalling integrator [Source:MGI Symbol;Acc:MGI:1349469])

HSP 1 Score: 161.77 bits (408), Expect = 1.489e-44
Identity = 97/336 (28.87%), Postives = 164/336 (48.81%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNI-------NEVMINDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRA-----------IYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDLVN 1290
            +RGHV+F+   L+KM  F V R+L +Y  +LD+FP+    P+++ Q    HYP+QQ+C + +L  ME +G++P  +   +L + FG  + P+ ++ RM  W  + KN+NPYPVP+DLP DP ++A++ L  + P    +V +       +   + D  +  IV  QS  Q+        +L   N  R V+V+GP+ +W+RN+ V Y +L +DL                +YY Q  + +    +  +D++    D  TE PV                            A C+   ++ ++L  W+  + + NP L    VVFR+    G+L+ 
Sbjct:  103 KRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFPKEVFRPRNVIQRIFVHYPRQQECGVAVLEQMERHGVMPSAETEFLLIQIFGRKSYPMLKFLRMKLWFTRFKNINPYPVPRDLPQDPLDLAKLGLRHMEPDLSAKVTVYQMSLPSDSTGMEDPTQPHIVGIQSPDQQA-------ALARHNPSRPVFVEGPFPLWLRNKCVYYHILRADLPPPEEEKVEEIPEEWELYYPQKLDLE--YSRSGWDDYEFDVDEVTEGPV---------------------------FAMCMAGAHDQATLIKWIQGLQETNPTLAQIPVVFRLARSTGELLT 402
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Mouse
Match: Ecsit (ECSIT signalling integrator [Source:MGI Symbol;Acc:MGI:1349469])

HSP 1 Score: 161.77 bits (408), Expect = 1.489e-44
Identity = 97/336 (28.87%), Postives = 164/336 (48.81%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNI-------NEVMINDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRA-----------IYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDLVN 1290
            +RGHV+F+   L+KM  F V R+L +Y  +LD+FP+    P+++ Q    HYP+QQ+C + +L  ME +G++P  +   +L + FG  + P+ ++ RM  W  + KN+NPYPVP+DLP DP ++A++ L  + P    +V +       +   + D  +  IV  QS  Q+        +L   N  R V+V+GP+ +W+RN+ V Y +L +DL                +YY Q  + +    +  +D++    D  TE PV                            A C+   ++ ++L  W+  + + NP L    VVFR+    G+L+ 
Sbjct:  103 KRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFPKEVFRPRNVIQRIFVHYPRQQECGVAVLEQMERHGVMPSAETEFLLIQIFGRKSYPMLKFLRMKLWFTRFKNINPYPVPRDLPQDPLDLAKLGLRHMEPDLSAKVTVYQMSLPSDSTGMEDPTQPHIVGIQSPDQQA-------ALARHNPSRPVFVEGPFPLWLRNKCVYYHILRADLPPPEEEKVEEIPEEWELYYPQKLDLE--YSRSGWDDYEFDVDEVTEGPV---------------------------FAMCMAGAHDQATLIKWIQGLQETNPTLAQIPVVFRLARSTGELLT 402
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Mouse
Match: Ecsit (ECSIT signalling integrator [Source:MGI Symbol;Acc:MGI:1349469])

HSP 1 Score: 161.77 bits (408), Expect = 1.489e-44
Identity = 97/336 (28.87%), Postives = 164/336 (48.81%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNI-------NEVMINDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRA-----------IYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDLVN 1290
            +RGHV+F+   L+KM  F V R+L +Y  +LD+FP+    P+++ Q    HYP+QQ+C + +L  ME +G++P  +   +L + FG  + P+ ++ RM  W  + KN+NPYPVP+DLP DP ++A++ L  + P    +V +       +   + D  +  IV  QS  Q+        +L   N  R V+V+GP+ +W+RN+ V Y +L +DL                +YY Q  + +    +  +D++    D  TE PV                            A C+   ++ ++L  W+  + + NP L    VVFR+    G+L+ 
Sbjct:  103 KRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFPKEVFRPRNVIQRIFVHYPRQQECGVAVLEQMERHGVMPSAETEFLLIQIFGRKSYPMLKFLRMKLWFTRFKNINPYPVPRDLPQDPLDLAKLGLRHMEPDLSAKVTVYQMSLPSDSTGMEDPTQPHIVGIQSPDQQA-------ALARHNPSRPVFVEGPFPLWLRNKCVYYHILRADLPPPEEEKVEEIPEEWELYYPQKLDLE--YSRSGWDDYEFDVDEVTEGPV---------------------------FAMCMAGAHDQATLIKWIQGLQETNPTLAQIPVVFRLARSTGELLT 402
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Mouse
Match: Ecsit (ECSIT signalling integrator [Source:MGI Symbol;Acc:MGI:1349469])

HSP 1 Score: 137.117 bits (344), Expect = 1.699e-37
Identity = 67/198 (33.84%), Postives = 112/198 (56.57%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNI-------NEVMINDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAV 909
            +RGHV+F+   L+KM  F V R+L +Y  +LD+FP+    P+++ Q    HYP+QQ+C + +L  ME +G++P  +   +L + FG  + P+ ++ RM  W  + KN+NPYPVP+DLP DP ++A++ L  + P    +V +       +   + D  +  IV  QS  Q+        +L   N  R V+V+GP+ +
Sbjct:   33 KRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFPKEVFRPRNVIQRIFVHYPRQQECGVAVLEQMERHGVMPSAETEFLLIQIFGRKSYPMLKFLRMKLWFTRFKNINPYPVPRDLPQDPLDLAKLGLRHMEPDLSAKVTVYQMSLPSDSTGMEDPTQPHIVGIQSPDQQA-------ALARHNPSRPVFVEGPFPL 223
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. UniProt/SwissProt
Match: sp|Q9U6M0|ECSIT_DROME (Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial OS=Drosophila melanogaster OX=7227 GN=ECSIT PE=1 SV=2)

HSP 1 Score: 199.134 bits (505), Expect = 5.449e-58
Identity = 111/313 (35.46%), Postives = 173/313 (55.27%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNI----NEVMINDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRV-IKENPELNDFRVVFR 1260
            RR HVEF+   LK M  F V R+L++YK ++++ P+ K IP +++QAE  HYPKQQ C I +L  ME+ G++PD +   ML   FG    P+ +Y RM+YWMPK KNL+P+P+P  +P+D  E+A++AL R+  + D R  I       + +  D TWIVS  S  Q+ L       L   ++++ +Y++GP+ +W+RN+R+NYF L +D D     +  +L E Q   D V +           E+P     P R+     +L     + +G +I+A C T  +   SL  W+  +    NP + +  V+FR
Sbjct:   83 RRNHVEFIYAALKNMADFGVERDLEVYKALINVMPKGKFIPTNMFQAEFMHYPKQQQCIIDLLEQMEDCGVMPDHEMEAMLLNVFGRQGHPLRKYWRMMYWMPKFKNLSPWPLPDPVPDDTLEMAKLALERMCTV-DLRSKITVFETSELKDAIDDTWIVSGMSPEQEKL-------LREHSRQKALYIEGPFHIWLRNRRINYFTLRADADSE---FLSELDERQLDEDDVSH----------IEVPFFGRAPPRRHNQLGKLRSVHQQDDG-TIMAICATGTSTKDSLLSWIRLLEANGNPSIGEVPVLFR 373
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. UniProt/SwissProt
Match: sp|Q08CK1|ECSIT_DANRE (Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial OS=Danio rerio OX=7955 GN=ecsit PE=2 SV=1)

HSP 1 Score: 177.563 bits (449), Expect = 1.980e-49
Identity = 100/323 (30.96%), Postives = 171/323 (52.94%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMINDHDKTW-------IVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDL 1284
            RRGHVEF+   LKKM  F V  ++ +Y K+LD+FP+   +P++  Q    HYP+QQ+C +++L  ME  G++P+ +   +L + FG  + P+ ++QR++YW PK K+ NPYPVP  LP+DP ++A+ +LTR+    D ++ I +    D  +T        IV  QS  Q++L       L   N  + V+V+GPY +W+R + V+Y+LL +D         +++       ++  +       D    + V  GD         + +   DE+E  ++ A C+    + ++L  W++ + +  P L     VFR+  GP +L
Sbjct:  116 RRGHVEFIYAALKKMPEFGVECDVTVYNKLLDVFPKEVFVPQNFIQRMFNHYPRQQECGVQVLEQMENYGVMPNIETKVLLVQIFGEKSHPIRKFQRIMYWFPKFKHTNPYPVPHVLPSDPVDLAQFSLTRIAADLDAKITIYQYPSTDITETGEEITRPHIVGIQSPDQRSL-------LAKHNPCKPVFVEGPYPLWLRQKCVHYYLLRADPIPPEEKVEEEIDPEMICPEQSLFFPQRVELD----LKVDMGD---------DHSFNVDEVEEGAVYAMCMAGQGDQATLSQWISGLQETCPILGQIPTVFRLESGPREL 418
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. UniProt/SwissProt
Match: sp|Q0V9C9|ECSIT_XENTR (Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial OS=Xenopus tropicalis OX=8364 GN=ecsit PE=2 SV=1)

HSP 1 Score: 175.252 bits (443), Expect = 7.400e-49
Identity = 103/323 (31.89%), Postives = 173/323 (53.56%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMIN-------DHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDL 1284
            RRGHVE +   L+ M  F V ++L++Y K+LD+FP+   +P++  Q    HYP+QQ+CAI++L  ME  G+ P++    +L + FG  + P+ +YQRM+YW P+ K+ NP+PVP +LP DP E++R+ L R+    D+RV + ++          + +   +V  QS +Q +L++  N S         VYV+GP+ +W+R   V Y++L +D D  R       +E +  N++  Y             P+   D    + L  + +   D++E   + A C+  + +   L  W+  + + NP L    VVFR+N GP +L
Sbjct:   89 RRGHVEIIEAALRWMTEFGVEKDLEVYNKLLDVFPKEVFVPQNYIQRMFNHYPRQQECAIRVLEQMENYGITPNKQTCFLLLQIFGARSHPIRKYQRMMYWFPRFKHTNPFPVPAELPADPVELSRMCLHRIANDLDSRVAVYQMPYTEKCDDGKEREHLHVVGIQSPSQVSLLAAHNPSTP-------VYVEGPFPLWLRKTCVYYYILRADPDPMR-------KEEEIDNERSLY------------YPLSL-DLELDRDLGDDDSFDVDDVEEGPVFAMCMAGSGDELLLGKWIRGLQETNPILGQTPVVFRLNSGPQEL 384
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. UniProt/SwissProt
Match: sp|A2VD95|ECSIT_XENLA (Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial OS=Xenopus laevis OX=8355 GN=ecsit PE=2 SV=1)

HSP 1 Score: 173.711 bits (439), Expect = 2.153e-48
Identity = 104/334 (31.14%), Postives = 175/334 (52.40%), Query Frame = 1 
Query:  304 ILAYLMKYGSSRRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMIN-------DHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDL 1284
            +L    K  + RRGHVE +   L+ M  F V ++L++Y K+LD+FP+   IP++  Q    HYP+QQ+CAI++L  ME  G+ P++    +L + FG  + P+ +YQRM+YW P+ K  NP+PVP +LP DP E++R+ L R+    D+RV ++++          + +   IV  QS +Q +L++  + S         VYV+GP+ +W++   V Y++L +D D           E +  N++ FY             P+   D    + L  + +   D++    + A C+  + +   L  W+  + + NP L    VVFR+N GP +L
Sbjct:   76 VLDLYCKRDTRRRGHVEIIETALRWMPEFGVEKDLEVYNKLLDVFPKEIFIPQNFIQRMFNHYPRQQECAIRVLEQMEHYGITPNKQTCFLLLQIFGDRSHPIKKYQRMMYWFPRFKYTNPFPVPAELPADPVELSRMCLHRIAADLDSRVAVHQMPYTEKCDDGKEQEHLHIVGIQSPSQVSLLAAHDPSTP-------VYVEGPFPLWLKKTCVYYYILRADPDPME-------NEEEIDNERSFY------------YPLSL-DIQLDRDLGDDDSFDVDDVVEGPVFAMCMAGSGDERLLGKWIRGLQETNPILGQTPVVFRLNSGPQEL 382
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. UniProt/SwissProt
Match: sp|Q3SX05|ECSIT_BOVIN (Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial OS=Bos taurus OX=9913 GN=ECSIT PE=2 SV=1)

HSP 1 Score: 164.081 bits (414), Expect = 1.356e-44
Identity = 97/326 (29.75%), Postives = 175/326 (53.68%), Query Frame = 1 
Query:  322 KYGSSRRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMI-------NDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPG 1278
            +Y   +RGHV+F+   L+KM+ + V R+L +Y  +LDIFP+    P++I+ +   HYP+QQ+C I +L  ME +G++P+++   +L + FG  + P+ +  RM  W  + KN+NP+PVP+DLP DP ++A +AL  + P    RV   ++ +        D  +T IV  QS  Q++       +L   +  R ++V+GP+++W+R++ V Y +L +DL        +++ E             + ++ P  ++ + +G  S       E  I  DE+E   + A C+   ++ ++L  W+  + + NP L    VVFR++   G
Sbjct:   98 EYNVHKRGHVDFIYLALRKMREYGVERDLSVYNLLLDIFPKEVFRPRNIFHSIFLHYPRQQECGIAVLEQMENHGVMPNKETEFLLLQIFGRKSYPMLKLVRMKLWFTRFKNINPFPVPRDLPQDPVDLASLALRHMEPDLSARVTTYQMPLLKDSPNAMDPTETHIVGIQSPEQQS-------ALARHDPARPIFVEGPFSLWLRDKCVYYHILRADLLPPEEREVEEIPEE------------WNLYYP-MQLDLAYGRSSWDD---YEFNI--DEVEEGPVFAICVAGAHDQATLAKWIQGLQETNPALARIPVVFRLSGSSG 398
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. TrEMBL
Match: R7UQ55 (ECSIT_Cterm domain-containing protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_163254 PE=4 SV=1)

HSP 1 Score: 228.024 bits (580), Expect = 1.203e-66
Identity = 132/326 (40.49%), Postives = 192/326 (58.90%), Query Frame = 1 
Query:  292 FEEAILAYLMKYGSSRRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNI--NEVMINDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYED--EMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVF 1257
            F  A+  YL      RRGHVEF+   L+KMK F VHR+L+ YKKILD+FP+ K+ P+S WQAEL HYPKQQ CAI +L  MEENG+IPD+D G  L   F   +    RYQRM+YW+PK K+ NPYPVP+DLPND  E+A++AL R+    +  +++   + + +  DKT+IVSAQS+TQ+ LI+ L +  +       V V+G +  ++R +   YF+L ++  K +A  ++ +   ++ N   F++              +F D       P+EL I     E E  ++LA CIT  ++  SL  W+  +  ENP L++  VVF
Sbjct:   70 FIAAVSKYLDHENVYRRGHVEFVYASLEKMKEFNVHRDLETYKKILDLFPKEKLKPQSSWQAELMHYPKQQQCAIDLLEHMEENGVIPDDDMGYALINIFSQRSHVFRRYQRMMYWLPKFKHQNPYPVPRDLPNDNVELAKLALARMAVDLENEISVFQTDDLESAADKTFIVSAQSQTQRDLITSLPKGQS-------VTVEGGFITYLRYKSFIYFVLKAEKTK-KAKDFENITGKRKDNASTFWN--------------YFEDEQ-----PSELAIRPSVHEQEDGTVLAMCITGTSSKDSLASWLKYLEVENPNLSNTPVVF 368
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. TrEMBL
Match: A0A0L8GXH8 (ECSIT_Cterm domain-containing protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22026147mg PE=4 SV=1)

HSP 1 Score: 214.927 bits (546), Expect = 2.314e-61
Identity = 122/328 (37.20%), Postives = 191/328 (58.23%), Query Frame = 1 
Query:  289 IFEEAILAYLMKYGSSRRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNI---NEVMINDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRV 1263
            +F+ A+  Y++K    RRGHVEF    + K+K F   R+L  YKKIL++FP+ KMIPK+ WQ E+ HYPKQQ C I +L TME N +IPD +FG +L   FGL      +YQRM+YW+PKMKNLNPY VP  LP DP+ +A +AL R+    + ++++    E+  +    T+I SAQS +Q+ L       L   ++   + V+G + VW+RN    YF+L ++ + + ++  K ++  +++N+    D+   +F  N      F +      L    ++++ + EG +ILA CIT  +  +SL  W+  + K NP+L    VVF++
Sbjct:   90 MFKAAVDGYIIKENVYRRGHVEFAYAAVNKLKAFGSERDLSSYKKILEVFPKYKMIPKNAWQVEMMHYPKQQQCVIDMLDTMERNAVIPDMEFGIILSEIFGLKAHVFRKYQRMMYWLPKMKNLNPYHVPLYLPEDPTYLAILALKRMAVDLENKISLFWTTEIEKDPEVNTFIASAQSPSQQEL-------LNKHDELSPLTVEGGHTVWLRNVLQTYFVLIAEKNPNESL--KAVEAGKKLNED---DDADDLFGWNV-----FTEEEHHTQLSLSTSLHQ-QPEG-TILAMCITGTSTKASLVTWIRGLQKTNPKLEKIPVVFKL 398
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. TrEMBL
Match: A0A2T7PAQ1 (ECSIT_Cterm domain-containing protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_09753 PE=4 SV=1)

HSP 1 Score: 208.379 bits (529), Expect = 1.339e-59
Identity = 122/335 (36.42%), Postives = 190/335 (56.72%), Query Frame = 1 
Query:  283 QLIFEEAILAYLMKYGSSRRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNI--NEVMINDHDK-TWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPG 1278
            +L F  A+  Y+ K    RRGHVEF+   L+ M+ F VHR+L +YK++L++FP+ KMIP+S WQ E  H+PKQQ CAI ++  ME+ G+IPD +FG  L + FG       +Y+RM+YWMPK K+ NPYP+P++LP D  ++A +AL R++  RD+ + +   E +  ++ K T+I S+QS TQK+LI          N +  ++V+G +  W+R   + YF+L +D DK     Y + +     +D +F  NW             F +    K++  + +++  E +  ++LA  IT N    SL  WV  +   NP L    VVF++   PG
Sbjct:   34 KLTFCSAVQLYITKELKYRRGHVEFIYSALENMERFGVHRDLSVYKELLEVFPKEKMIPRSTWQVEWQHFPKQQQCAIDLMDQMEDYGVIPDHNFGARLEKIFGTEAHAFRKYRRMMYWMPKFKHANPYPIPKELPVDALQLALLALKRMSVDRDSEITVWQGEGVDGENTKETFIASSQSHTQKSLIE-------KHNSDTPLFVEGGFTCWLRYASMTYFILRADPDKKMLKRYAEAEAAAASDDNLF--NWNL-----------FWEKEEAKSIVPQRSVH--EQDDGTVLAMVITGNATKESLVSWVRCLQTTNPALEKIPVVFKLRT-PG 345
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. TrEMBL
Match: A0A1W4XFH4 (evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 OS=Agrilus planipennis OX=224129 GN=LOC108743789 PE=4 SV=1)

HSP 1 Score: 207.994 bits (528), Expect = 3.463e-59
Identity = 125/322 (38.82%), Postives = 186/322 (57.76%), Query Frame = 1 
Query:  328 GSSRRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMIND----HDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIK-ENPELNDFRVVFRVNLGPG 1278
            GS RRGHVEF+   LK MK F VH++L++YK ++D+ P+ + IP +I+QAE  HYPKQQ C I +L  ME+NG++PD +   +L   FG    P+ ++ RM+YWMPK KNL+P+PVP  LPND  E+A+IA+ R+  + D + +I     +D     + TWIVSAQS TQK L       L+  N+E  VYV+G + VW++N+ VNYF+L  D               + +N +V  +N   V   N E+P+      ++K L    +++E + EG  I + C T  +   S+  W+  + K +NP L    V+F +   PG
Sbjct:   76 GSHRRGHVEFIYAALKNMKEFGVHKDLEVYKALIDVMPKGRFIPTNIFQAEFMHYPKQQQCIIDLLEQMEDNGVMPDFEIESILLNIFGKRGYPLRKFWRMMYWMPKFKNLSPWPVPDPLPNDVLELAKIAIARIASV-DVQTSITVFKTSDIPDSVEDTWIVSAQSITQKKL-------LSEHNKENPVYVEGTFKVWIKNKCVNYFILRGD--------------PKPVNTEV--ENLDDV--SNIEVPLFTISTPQEKKLNLIPSVHE-QPEG-VIYSVCATGTSGRDSVLSWIRHLEKNDNPCLASIPVIFTLK-SPG 368
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. TrEMBL
Match: A0A2C9JTJ3 (ECSIT_Cterm domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106067693 PE=4 SV=1)

HSP 1 Score: 207.223 bits (526), Expect = 8.616e-59
Identity = 128/358 (35.75%), Postives = 201/358 (56.15%), Query Frame = 1 
Query:  229 KIKTIQTKGELKATAFVKQLIFEE---------AILAYLMKYGSSRRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNI---NEVMIND-HDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRV 1263
            +I +   K E+KA + +KQ+  E+         AI  Y+ +    RRG VEF+   + +MK F V+R+L  YK +L +FPE KMIP++IWQ E  HYP+QQ C I +L  ME NG+IPD++FG +L  RFG       +Y RM+YW+PK KN+NPYP+P  LP+DP ++A   L R+   ++T+ ++    E+  N   + T+IVSAQS  Q+ L+S  N +L        ++V+GPY V++R  + +YFLL ++ +       KQ +  +     +F   W   FD +             K++   ++++E   E  +ILA CIT   + SS++ W+  + K NP L    V+F++
Sbjct:   34 RITSESRKLEVKAKSLLKQIANEKGTDKAAFLYAINTYISQETLYRRGAVEFIYSAMYEMKTFGVNRDLTAYKALLQVFPEGKMIPRNIWQVEFMHYPRQQQCGIDMLEQMEVNGVIPDDEFGVLLKNRFGSTAHVTRKYLRMMYWLPKFKNINPYPIPYILPSDPIQIALFMLKRMCVDQETKYSVLKTTELEENSTQEDTYIVSAQSPIQQELLSKHNCNLP-------LFVEGPYPVYLRYLQKHYFLLRAEPNIKILRQKKQQEIEEEKEKNMF--EWINFFDEDY------------KSIKPVVSVHEQ--EDSTILALCITGTCSKSSVQTWIRWLEKSNPNLTTTPVLFKL 368
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Cavefish
Match: ecsit (ECSIT signaling integrator [Source:NCBI gene;Acc:103031013])

HSP 1 Score: 179.489 bits (454), Expect = 4.978e-51
Identity = 111/369 (30.08%), Postives = 187/369 (50.68%), Query Frame = 1 
Query:  205 ELFEISENKIKTIQTKGEL--KATAFVKQLIFEEAILAYLMKYGSSRRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMINDHDKTW-------IVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDL 1284
            +LFE +E K K++ T  +L  +     K       ++    K    RRGHVEF+   L+KM  F V R+L +Y K+LD+FP+   +P++  Q    HYP+QQ+CA+++L  ME  G++P+ +   +L + FG    PV +YQR++YW+PK K++NP+PVP +LP DP ++AR +LTR+    D ++ + +    D  +T        IV  Q   Q +L       L   N  R V+V+GP+ +W+R   V Y+LL +DL         +        ++  +  W    D + ++    GD         + +   +++E   + A C+    + ++L  W+  + + NP L     VFR+  G  +L
Sbjct:   68 KLFE-NETKAKSLVTHDDLFERTAKDAKNKASFNRVVDVFNKQDIRRRGHVEFIYAALQKMPEFGVERDLAVYNKLLDVFPKEVFVPRNFIQRMFNHYPRQQECAVQVLEQMENYGIVPNVETKVLLVQIFGEKGHPVRKYQRLMYWLPKFKHINPFPVPFELPQDPIDLARFSLTRIANDLDAKITVYQYPSTDVTETGEEVTQPHIVGIQGPEQISL-------LAKHNPNRPVFVEGPFPLWLRKTCVQYYLLRADLVPPEERVQDEPDPELVGPNQCLFYPWQIDLDLSRDM----GD---------DFSYDVEDVEEGPVYAMCMAGQGDQATLARWICGLQETNPILGRIPTVFRLESGSREL 415
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Sea Lamprey
Match: ECSIT (ECSIT signaling integrator [Source:HGNC Symbol;Acc:HGNC:29548])

HSP 1 Score: 179.489 bits (454), Expect = 7.313e-53
Identity = 105/323 (32.51%), Postives = 173/323 (53.56%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNI-----NEVMINDHD--KTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDL 1284
            RRGHV+F+   L+ M+ + VH ++ +Y ++LD+ P+   +P+++ Q    HYP+QQ C I +L  ME  GL+PD++   +L + +G  + P  +Y+R+LYW P+MK++NPYPVP  LP+DP  +A +ALTR+    DT+V +     N+V  +  D  K +IV  QS  Q+ L+S           ER VYV+GP  +W+R+  V+Y++L  D     A + K   +N  I      D   +++ P                L  + +    E+E   + A C+    + ++L HW++ +   NP L    ++FR+   P DL
Sbjct:   39 RRGHVDFVYAALRCMRDYGVHHDIAVYNRLLDVIPKGVFVPRNVIQRTFNHYPRQQQCGIAVLEQMENYGLMPDKETRSLLIQIYGQLSHPYRKYRRILYWFPRMKHVNPYPVPVTLPSDPVTLASLALTRMADDLDTKVTVYQSSYNDVTEDGRDVTKPYIVGIQSPDQQELLSR-------HRPERPVYVEGPSRLWLRDANVSYYVLRGD---PLAPHEKLCPQNPPI------DPERSLYYPLQLDL------DLTLDLSDDFSFDVKEVEEGPVFAMCMVGRGDQATLGHWLSGLQLSNPVLGRTPIIFRLESTPSDL 339
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Nematostella
Match: EDO47956 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKS6])

HSP 1 Score: 105.145 bits (261), Expect = 2.541e-25
Identity = 87/369 (23.58%), Postives = 168/369 (45.53%), Query Frame = 1 
Query:  199 SEELFEISENKIKTIQTKGELKATAFVKQLIFEEA------------ILAYLMKYGSSRRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMINDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENN-NLSSLRHWVNRVIKENPELNDFRVVFRVN 1266
            ++ + E+SE  I++  T  +   + F   L FE A            IL    ++  +RRGH+E +   +  M ++ + ++L  Y  +LD+FP  +   ++++ A       Q D A++IL  MEEN + P  +   +    FG  + PV + +R+ YW+ K++ + P P+P +LP    E++ +A+ R++      + + + +   + + +IVS+Q+  Q+ L+   +  +        VYV+GPY +WV+  R +++ L       RA Y                         N  IP                    D+ EG  +LA C+T  +    +L++W+ ++ K +P L +  V+F ++
Sbjct:   12 NDTVIELSEKAIESRITSAKPAPSKFA--LRFETALSQGKTRDNFIEILESFSRHDRNRRGHMELLKTAMNYMDIYGLEKDLLAYNAMLDVFPRGRFQNRTLFDAVWPKKHPQVDLALEILTKMEENVIKPSIETYDICEEIFGKASQPVQKVRRLAYWLTKLEEMFPSPLPAELPEGELELSMVAMERMSK-EGLPIVVFQDLSEGNSEEFIVSSQTPEQQALLGKHDIVVP-------VYVEGPYFLWVKRIRRHFYTL-------RAPYTGS----------------------NDGIP-------------------PDDTEG-VVLAVCMTSPDCTQDNLKNWILQLQKTSPNLANINVIFNLD 321
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Medaka
Match: ecsit (ECSIT signaling integrator [Source:NCBI gene;Acc:101156202])

HSP 1 Score: 180.644 bits (457), Expect = 1.334e-51
Identity = 103/334 (30.84%), Postives = 176/334 (52.69%), Query Frame = 1 
Query:  337 RRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMINDHDKT-------WIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSD-----------LDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDL 1284
            RRGHVEF+   L+KM  F V R+L +Y ++LD+FP+   +P +  Q    HYP+QQ+C +++L  ME  G+ P+ +   +L + FG  + P+ +YQR++YW PK K+LNP+P+PQ LP DP ++AR +LTR+    D +V ++++  +D  ++       +I+  QS  Q+ L       L   +  R V+V+GP+ +W+R+  V Y++L +D            D  R+ YY  LQ +  ++  V+ +  + V                           ED  EG  + A C+    + ++L  W++ + ++NP L     +FR++ GP  L
Sbjct:  111 RRGHVEFIYAALRKMPEFGVERDLGVYNRLLDVFPKEVFVPTNFIQRMFNHYPRQQECGVQLLEQMENYGITPNVETKVLLVQIFGEKSHPMRKYQRLMYWFPKFKHLNPFPIPQQLPEDPVDLARFSLTRIANDLDAKVTVHQLPCSDVTESGEEIHRPYILGIQSPGQREL-------LAKHDPRRPVFVEGPFPLWLRSTCVYYYVLRADPPLPQDQVEEPYDPERSFYYP-LQLDFSLDRDVWDEEGFDV---------------------------EDLDEG-PVFAMCMAGRGDRATLGQWISDLQRDNPVLGRVPTLFRLDPGPQHL 408
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Planmine SMEST
Match: SMESG000031438.1 (SMESG000031438.1)

HSP 1 Score: 838.18 bits (2164), Expect = 0.000e+0
Identity = 415/416 (99.76%), Postives = 416/416 (100.00%), Query Frame = 1 
Query:   46 MLSKLKFVTVVLSMKTTRNFHKTVPCSFFYQKLRKITQXXXXXXXXXXXXTSEELFEISENKIKTIQTKGELKATAFVKQLIFEEAILAYLMKYGSSRRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMINDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDLVNK 1293
            MLSKLKFVTVVLSMKTTRNFHKTVPCSFFYQKLRKITQEKKEIEDKKLIKTSEELFEISENKIKTIQTKGELKATAFVKQLIFEEAILAYLMKYGSSRRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMINDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGP+AVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDLVNK
Sbjct:    1 MLSKLKFVTVVLSMKTTRNFHKTVPCSFFYQKLRKITQEKKEIEDKKLIKTSEELFEISENKIKTIQTKGELKATAFVKQLIFEEAILAYLMKYGSSRRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMINDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPFAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDLVNK 416
[Close]
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Planmine SMEST
Match: SMESG000031438.1 (SMESG000031438.1)

HSP 1 Score: 812.757 bits (2098), Expect = 0.000e+0
Identity = 402/403 (99.75%), Postives = 403/403 (100.00%), Query Frame = 1 
Query:   85 MKTTRNFHKTVPCSFFYQKLRKITQXXXXXXXXXXXXTSEELFEISENKIKTIQTKGELKATAFVKQLIFEEAILAYLMKYGSSRRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMINDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDLVNK 1293
            MKTTRNFHKTVPCSFFYQKLRKITQEKKEIEDKKLIKTSEELFEISENKIKTIQTKGELKATAFVKQLIFEEAILAYLMKYGSSRRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMINDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGP+AVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDLVNK
Sbjct:    1 MKTTRNFHKTVPCSFFYQKLRKITQEKKEIEDKKLIKTSEELFEISENKIKTIQTKGELKATAFVKQLIFEEAILAYLMKYGSSRRGHVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYPKQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMPKMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMINDHDKTWIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPFAVWVRNQRVNYFLLTSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQKALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDFRVVFRVNLGPGDLVNK 403
The following BLAST results are available for this feature:
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ECSIT2.392e-4329.36ECSIT signaling integrator [Source:HGNC Symbol;Acc... [more]
ECSIT2.803e-3735.50ECSIT signaling integrator [Source:HGNC Symbol;Acc... [more]
ECSIT1.012e-3138.62ECSIT signaling integrator [Source:HGNC Symbol;Acc... [more]
ECSIT1.166e-3138.62ECSIT signaling integrator [Source:HGNC Symbol;Acc... [more]
ECSIT1.995e-2940.00ECSIT signaling integrator [Source:HGNC Symbol;Acc... [more]
back to top
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Y17G9B.51.219e-3929.91pep chromosome:WBcel235:IV:4750240:4751491:1 gene:... [more]
back to top
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ECSIT5.436e-5935.46gene:FBgn0028436 transcript:FBtr0078647[more]
back to top
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ecsit1.096e-5031.27ECSIT signaling integrator [Source:NCBI gene;Acc:5... [more]
ecsit1.096e-5031.27ECSIT signaling integrator [Source:NCBI gene;Acc:5... [more]
ecsit1.096e-5031.27ECSIT signaling integrator [Source:NCBI gene;Acc:5... [more]
ecsit5.251e-3838.20ECSIT signaling integrator [Source:NCBI gene;Acc:5... [more]
back to top
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
wars11.397e-4931.89tryptophanyl-tRNA synthetase 1 [Source:Xenbase;Acc... [more]
back to top
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Ecsit1.489e-4428.87ECSIT signalling integrator [Source:MGI Symbol;Acc... [more]
Ecsit1.489e-4428.87ECSIT signalling integrator [Source:MGI Symbol;Acc... [more]
Ecsit1.489e-4428.87ECSIT signalling integrator [Source:MGI Symbol;Acc... [more]
Ecsit1.699e-3733.84ECSIT signalling integrator [Source:MGI Symbol;Acc... [more]
back to top
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9U6M0|ECSIT_DROME5.449e-5835.46Evolutionarily conserved signaling intermediate in... [more]
sp|Q08CK1|ECSIT_DANRE1.980e-4930.96Evolutionarily conserved signaling intermediate in... [more]
sp|Q0V9C9|ECSIT_XENTR7.400e-4931.89Evolutionarily conserved signaling intermediate in... [more]
sp|A2VD95|ECSIT_XENLA2.153e-4831.14Evolutionarily conserved signaling intermediate in... [more]
sp|Q3SX05|ECSIT_BOVIN1.356e-4429.75Evolutionarily conserved signaling intermediate in... [more]
back to top
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
R7UQ551.203e-6640.49ECSIT_Cterm domain-containing protein OS=Capitella... [more]
A0A0L8GXH82.314e-6137.20ECSIT_Cterm domain-containing protein OS=Octopus b... [more]
A0A2T7PAQ11.339e-5936.42ECSIT_Cterm domain-containing protein OS=Pomacea c... [more]
A0A1W4XFH43.463e-5938.82evolutionarily conserved signaling intermediate in... [more]
A0A2C9JTJ38.616e-5935.75ECSIT_Cterm domain-containing protein OS=Biomphala... [more]
back to top
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ecsit4.978e-5130.08ECSIT signaling integrator [Source:NCBI gene;Acc:1... [more]
back to top
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ECSIT7.313e-5332.51ECSIT signaling integrator [Source:HGNC Symbol;Acc... [more]
back to top
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO479562.541e-2523.58Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ecsit1.334e-5130.84ECSIT signaling integrator [Source:NCBI gene;Acc:1... [more]
back to top
BLAST of Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000031438.10.000e+099.76SMESG000031438.1[more]
SMESG000031438.10.000e+099.75SMESG000031438.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30024207 ID=SMED30024207|Name=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial|organism=Schmidtea mediterranea sexual|type=transcript|length=1319bp
ATAAATTTTTCGCACAAAATTAAAAAATAAATATCTTGGCTGCAAATGCT
TAGTAAATTGAAATTCGTTACTGTTGTATTATCGATGAAAACAACGAGAA
ATTTTCACAAAACAGTACCATGTAGTTTTTTTTATCAAAAGTTAAGAAAA
ATTACGCAGGAGAAAAAAGAAATAGAAGACAAGAAATTGATTAAAACTTC
TGAAGAACTATTTGAGATAAGTGAAAATAAAATTAAAACCATTCAAACTA
AAGGTGAATTAAAAGCAACAGCTTTTGTTAAGCAGTTGATTTTTGAAGAA
GCTATTTTGGCATATCTAATGAAATATGGTAGTTCTCGACGCGGTCATGT
GGAATTTATGTTAGAATGTTTAAAAAAAATGAAAGTCTTTGAAGTTCATA
GAAATTTAGATATGTATAAAAAAATTCTTGACATTTTTCCTGAAGTGAAA
ATGATTCCAAAATCAATCTGGCAAGCGGAATTGTTTCATTATCCCAAACA
GCAGGATTGTGCAATTAAAATTCTTTGTACAATGGAAGAAAATGGCTTAA
TACCCGATGAGGACTTTGGAAGAATGCTTTTCCGACGTTTCGGACTTCAC
ACATCTCCAGTAGCTCGATATCAAAGAATGCTTTATTGGATGCCGAAAAT
GAAGAATTTAAATCCATATCCAGTGCCCCAGGATCTTCCGAACGATCCTA
GTGAAGTTGCTCGTATTGCTTTGACTCGATTAAATCCAATCAGAGACACT
CGAGTTAACATAAATGAAGTCATGATAAATGACCATGATAAAACTTGGAT
AGTTAGTGCGCAAAGTAAAACTCAGAAAACCTTGATCAGTTATCTCAATC
AATCTCTTACCGGTGAAAATCAGGAACGGCTGGTTTACGTAGATGGCCCA
TACGCAGTATGGGTGAGGAATCAGAGGGTGAATTACTTTTTACTGACCTC
GGATCTCGATAAAAGCCGAGCGATTTATTATAAACAATTACAAGAAAATC
AAAGAATCAATGACAAAGTGTTTTACGATAATTGGTATACAGTTTTTGAT
CCTAACACTGAAATTCCGGTTCATTTCGGAGATCCATCCAGACAAAAGGC
TTTACCAGCTGAATTGACAATATATGAAGATGAGATGGAAGGTCGATCTA
TTCTGGCAAGCTGTATTACTGAAAATAATAATTTGAGCTCTTTGAGACAT
TGGGTTAATCGTGTTATAAAGGAAAATCCCGAATTAAATGATTTCAGAGT
TGTATTTAGGGTAAATCTTGGCCCCGGGGATTTAGTTAACAAATAAATAA
ATTTGGTTCTTCAAAACAA
back to top

protein sequence of SMED30024207-orf-1

>SMED30024207-orf-1 ID=SMED30024207-orf-1|Name=SMED30024207-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=417bp
MLSKLKFVTVVLSMKTTRNFHKTVPCSFFYQKLRKITQEKKEIEDKKLIK
TSEELFEISENKIKTIQTKGELKATAFVKQLIFEEAILAYLMKYGSSRRG
HVEFMLECLKKMKVFEVHRNLDMYKKILDIFPEVKMIPKSIWQAELFHYP
KQQDCAIKILCTMEENGLIPDEDFGRMLFRRFGLHTSPVARYQRMLYWMP
KMKNLNPYPVPQDLPNDPSEVARIALTRLNPIRDTRVNINEVMINDHDKT
WIVSAQSKTQKTLISYLNQSLTGENQERLVYVDGPYAVWVRNQRVNYFLL
TSDLDKSRAIYYKQLQENQRINDKVFYDNWYTVFDPNTEIPVHFGDPSRQ
KALPAELTIYEDEMEGRSILASCITENNNLSSLRHWVNRVIKENPELNDF
RVVFRVNLGPGDLVNK*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0061635regulation of protein complex stability
GO:0002376immune system process
GO:0045087innate immune response
GO:0051341regulation of oxidoreductase activity
GO:0055114oxidation-reduction process
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0002089reproductive organ
PLANA:0003001lateral region of the whole animal
Vocabulary: INTERPRO
TermDefinition
IPR029342ECIST_C
IPR010418ECSIT
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0016651oxidoreductase activity, acting on NAD(P)H
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005737cytoplasm
GO:0005739mitochondrion
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR029342ECSIT, C-terminal domainSMARTSM01284ECIST_Cterm_2coord: 257..407
e-value: 1.5E-8
score: 44.4
IPR029342ECSIT, C-terminal domainPFAMPF14784ECSIT_Ccoord: 271..405
e-value: 2.5E-17
score: 63.4
IPR010418ECSITPFAMPF06239ECSITcoord: 61..253
e-value: 1.7E-57
score: 194.2
IPR010418ECSITPANTHERPTHR13113ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYScoord: 17..413