Multidrug resistance-associated protein 1
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30024200 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 17
Homology
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC3 (ATP binding cassette subfamily C member 3 [Source:HGNC Symbol;Acc:HGNC:54]) HSP 1 Score: 830.476 bits (2144), Expect = 0.000e+0 Identity = 506/1366 (37.04%), Postives = 784/1366 (57.39%), Query Frame = 3
Query: 579 FLRFPP-----NLRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSE--------DEEFLINSE---EKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFL---IQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL-NESSDK--------------VDKNQNNLIQPSAPNK------------------RKRSRLSTSG-SQG-------FDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFG----NVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES--INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
F PP N+ +PE A S+L + W Y+ + +K + L ++S + + Q + ++E R S ++E L+ + K SF+ K L+ + FG+ F LI+ ++++D+L P +L +L+ + W ++ +FL +Q LI + +Y F ++ R ++G+I RK L ++ K + G+I+N+ VD ++ M+ + +L S P QIIL + L+ LG S+ GVA +V +IP+ A+ + + K++ KD R+ +++EILNGIKV+K+Y WE SF ++E IRQ EL+ R + + PFLV T Y+Y P +++ AEK F+++ LFN ++LP+ +LP ++ A VS RI +FL E+ P+S + +SPG +I I +G F+W + P L ++ + V K L+AVVG VG GKSSL+SA+LGEM L G V +G +AYVPQ+AWIQN TL+ N+L K+ N Y + L+AC L D+E LP DQTEIGE+G+NLSGGQ+QRVSLARAVY D+DI+LLDD LSAVD +V + +F+ +I +G+L KTRVLVTHG+ +LP D I V+ D GQ+SE G Y L+ F +FL N + D+ + + LI+ + N R+ S LS+ G QG +E + K ++ EE+ G V L S+ W Y KA G+ + LA + V Q+ NVWL + N++ + +N+ + Y +G+ Q V+L GG++A++ +H LL +RS FF+ TPSGRILN F+KD++++D L I ++N I++LVVI TP F +V +P+ + Y L+Q FY ++SRQ +RL+S + S + +H ET +G+S+IR+ DFE I +D + + +S RWL + ++ +GN +V + +FAV+ R SL+ LVGLS+SY+LQVT LNW+ R ++ E+N V++ER+++Y+ E+ + E + E W G + N+S++Y L VL++++++++GGEK+G+VGRTGAGKSS+ L LFR++E G I IDG+N+ IGLH LR QLTI+PQDP++FSGTL+ NLDPF Y+++ + +LE+S + +V+S G+++ C G NLS+GQ+QL+CLAR LL+KS+I++LDEATA++D ETD + I+ QF + TV+ IAHRL TI+D +++ LD G + EF SP L++ + G F +A+
Sbjct: 190 FREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQM---VVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL-----KALLAT-FGSSF---LISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFV----TGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQS---VERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLAD-GQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVEL-SVFWDYAKAVGL----CTTLAICLLYVGQSAAAIGANVWL------SAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVE-GSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIA-ARGIFYGMAR 1522
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC2 (ATP binding cassette subfamily C member 2 [Source:HGNC Symbol;Acc:HGNC:53]) HSP 1 Score: 825.469 bits (2131), Expect = 0.000e+0 Identity = 503/1341 (37.51%), Postives = 772/1341 (57.57%), Query Frame = 3
Query: 627 IASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGE----REDIFRRASKSEDEEFLI--------NSEEKESFILEH--------------SGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLM----DFGTEFKSFL-----------NESSDKVDKNQNNL-----IQPSAPN------------------------KRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELL 4439
IAS S +TY W DS I YK +T + +++ E+ + +S H E R + RR KS + S+ +++ +LE L+K++F + ++L + LL++V DI P +LKLL++ F + Y W G L A + LI S F L K+ ++VR +++ + +K L LS A+ Y+ G+ +N+ VD +++M+ + +L S QI+L++ L+ ELG S+ GV ++V VIP+ + +K K + KDKR+ I+ EIL+GIK++K + WE SF ++++++R++ELKN +S C++ +F L P LV TF+ Y+ +I+ A+K F +I LFN ++ P+ +LP ++ + A VS R+ K+L +++ + + +++ F+W ++++ L + +L+AV+G VG GKSSL+SA+LGEM ++G + +G AYVPQ++WIQN T+++NIL FN+ Y +VL+AC L D+E LP D EIGE+G+NLSGGQKQR+SLARA YQ+ DIYLLDD LSAVD +VG+ +FNK++ GLLK KTR+LVTH + +LP VDEI V+ + G I E+G+Y L+ +F K+FL ++ S++ D + + I A + K R+ L T +E + + + +E I +G+V + + Y +A G+F ILA V+ V N+WL + N++ + S+ + + YG +GL Q + V + FG + AS +H LL+ +LR+ ++FF+ TP+GRI+NRF D+ +D TL ++ I + +I++LV+I + TP F I+ IP+ I Y+ +Q+FY+S+SRQ RRLDS S + +H ET SG +IR+ E + F ID + K S RWL +RL+++GNL VF S + V+ R +LS VG +S AL +T LNWL R +E ETN V++ERI +YT + E+ T+ +W S G I N+ ++Y L VL+ IT +I EKIGVVGRTGAGKSSL LFR++E G+I IDGV+I SIGLH LR +LTI+PQDP++FSG+L+ NLDPF+ Y+D+++ K+LE++ + +V SL G++++ G NLS+GQ+QL+CL R LL+KSKI++LDEATA+VD ETD + I+ +F TVI IAHRL TI+D DK++ LD+G IIE GSP+ELL
Sbjct: 197 IASFLSSITYSWYDSIILKGYKRPLTLEDVWEVD--EEMKTKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLIS-FASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDDL----DTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGN-GTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQK-----LIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMR--VGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELL 1522
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 824.313 bits (2128), Expect = 0.000e+0 Identity = 504/1355 (37.20%), Postives = 778/1355 (57.42%), Query Frame = 3
Query: 594 PNLRETKH-----PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRR-----------ASKSEDEEFLINSEEKESFILEHSGK--------VLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLN---ESSDKVDKNQNNLIQPSAPNKRKR------------------------------SRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
P ET H PE AS S++T+ W+ I Y+ + DL S K + ++ N+ + R+ ++ ++ + +EE E+ I++ K VL K+ FG +F L++ + + D+++ + P +LKLL+ + + K W+G Y + + + ++ + F + +R++ +VIG + RK L ++ A+ + + G+I+N+ VD ++ M+ Y ++ S P Q+IL + LL+ LG S+ GVA++V ++PV + TK Y + KD R+ ++ EILNGIKV+K+Y WE +F +K+ +IRQEELK + + + + PFLV TF Y+ +I+ A+ F+++ LFN ++ P+ +LP ++ + A VS R+ FL E+ P S V SI ++N F+W R P L I ++ + L+AVVG+VG GKSSLLSA+L EM + G V +G +AYVPQ+AWIQN++LR NIL + +Y V+ AC L D+E LP+ D+TEIGE+GVNLSGGQKQRVSLARAVY ++DIYL DD LSAVD +VG+ +F +I +G+LK+KTR+LVTH + +LP VD I V++ G+ISE G+Y+ L+ F FL + + D +N + S P K + SR S ++ EE ++ + ++ +G+V L S+ W Y KA G+F+ SI + V N WL + D + N ++ K ++ YG +G+ Q +AV + GG+ AS+ +H LL ++LRS + FF TPSG ++NRF+K+L +D + I + +I + +VI + TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV++R SLSA LVGLS+SY+LQVT LNWL R +E ETN V++ER+++Y+ E+ I ET +W G + N+ L+Y +L VL++I + INGGEK+G+VGRTGAGKSSL L LFR+ E G I IDG+NI IGLH LR ++TI+PQDPV+FSG+L+ NLDPF +Y+D+++ SLE++ + D+V++L + ++++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D ++I LD G I E+G+P +LL G F ++A+
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGS---DLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKT-FGPYF---LMSFFFKAIHDLMMFSGPQILKLLIKFVNDT-KAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG-GKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWK-----LMEADKAQTGQVKL-SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTD------DPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAP--PSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL-QQRGLFYSMAK 1526
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 824.313 bits (2128), Expect = 0.000e+0 Identity = 504/1355 (37.20%), Postives = 778/1355 (57.42%), Query Frame = 3
Query: 594 PNLRETKH-----PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRR-----------ASKSEDEEFLINSEEKESFILEHSGK--------VLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLN---ESSDKVDKNQNNLIQPSAPNKRKR------------------------------SRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
P ET H PE AS S++T+ W+ I Y+ + DL S K + ++ N+ + R+ ++ ++ + +EE E+ I++ K VL K+ FG +F L++ + + D+++ + P +LKLL+ + + K W+G Y + + + ++ + F + +R++ +VIG + RK L ++ A+ + + G+I+N+ VD ++ M+ Y ++ S P Q+IL + LL+ LG S+ GVA++V ++PV + TK Y + KD R+ ++ EILNGIKV+K+Y WE +F +K+ +IRQEELK + + + + PFLV TF Y+ +I+ A+ F+++ LFN ++ P+ +LP ++ + A VS R+ FL E+ P S V SI ++N F+W R P L I ++ + L+AVVG+VG GKSSLLSA+L EM + G V +G +AYVPQ+AWIQN++LR NIL + +Y V+ AC L D+E LP+ D+TEIGE+GVNLSGGQKQRVSLARAVY ++DIYL DD LSAVD +VG+ +F +I +G+LK+KTR+LVTH + +LP VD I V++ G+ISE G+Y+ L+ F FL + + D +N + S P K + SR S ++ EE ++ + ++ +G+V L S+ W Y KA G+F+ SI + V N WL + D + N ++ K ++ YG +G+ Q +AV + GG+ AS+ +H LL ++LRS + FF TPSG ++NRF+K+L +D + I + +I + +VI + TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV++R SLSA LVGLS+SY+LQVT LNWL R +E ETN V++ER+++Y+ E+ I ET +W G + N+ L+Y +L VL++I + INGGEK+G+VGRTGAGKSSL L LFR+ E G I IDG+NI IGLH LR ++TI+PQDPV+FSG+L+ NLDPF +Y+D+++ SLE++ + D+V++L + ++++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D ++I LD G I E+G+P +LL G F ++A+
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGS---DLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKT-FGPYF---LMSFFFKAIHDLMMFSGPQILKLLIKFVNDT-KAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG-GKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWK-----LMEADKAQTGQVKL-SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTD------DPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAP--PSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL-QQRGLFYSMAK 1526
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 820.461 bits (2118), Expect = 0.000e+0 Identity = 504/1365 (36.92%), Postives = 778/1365 (57.00%), Query Frame = 3
Query: 594 PNLRETKH-----PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRR-----------ASKSEDEEFLINSEEKESFILEHSGK--------VLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL-------------NESSDKVDKNQNNLIQPSAPNKRKR------------------------------SRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
P ET H PE AS S++T+ W+ I Y+ + DL S K + ++ N+ + R+ ++ ++ + +EE E+ I++ K VL K+ FG +F L++ + + D+++ + P +LKLL+ + + K W+G Y + + + ++ + F + +R++ +VIG + RK L ++ A+ + + G+I+N+ VD ++ M+ Y ++ S P Q+IL + LL+ LG S+ GVA++V ++PV + TK Y + KD R+ ++ EILNGIKV+K+Y WE +F +K+ +IRQEELK + + + + PFLV TF Y+ +I+ A+ F+++ LFN ++ P+ +LP ++ + A VS R+ FL E+ P S V SI ++N F+W R P L I ++ + L+AVVG+VG GKSSLLSA+L EM + G V +G +AYVPQ+AWIQN++LR NIL + +Y V+ AC L D+E LP+ D+TEIGE+GVNLSGGQKQRVSLARAVY ++DIYL DD LSAVD +VG+ +F +I +G+LK+KTR+LVTH + +LP VD I V++ G+ISE G+Y+ L+ F FL S +D+ + + S P K + SR S ++ EE ++ + ++ +G+V L S+ W Y KA G+F+ SI + V N WL + D + N ++ K ++ YG +G+ Q +AV + GG+ AS+ +H LL ++LRS + FF TPSG ++NRF+K+L +D + I + +I + +VI + TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV++R SLSA LVGLS+SY+LQVT LNWL R +E ETN V++ER+++Y+ E+ I ET +W G + N+ L+Y +L VL++I + INGGEK+G+VGRTGAGKSSL L LFR+ E G I IDG+NI IGLH LR ++TI+PQDPV+FSG+L+ NLDPF +Y+D+++ SLE++ + D+V++L + ++++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D ++I LD G I E+G+P +LL G F ++A+
Sbjct: 95 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGS---DLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKT-FGPYF---LMSFFFKAIHDLMMFSGPQILKLLIKFVNDT-KAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG-GKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGSTVMDEEEAGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWK-----LMEADKAQTGQVKL-SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTD------DPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAP--PSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL-QQRGLFYSMAK 1435
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-1 (pep chromosome:WBcel235:X:576318:587483:-1 gene:WBGene00003407.1 transcript:F57C12.5c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-1) HSP 1 Score: 792.341 bits (2045), Expect = 0.000e+0 Identity = 522/1542 (33.85%), Postives = 838/1542 (54.35%), Query Frame = 3
Query: 42 DSFWSNSHLQSPNYPIFTNCFQYTLLIIGPSIFFITFSILLLERLFNKKHLKIITFHSFDLRHSXXXXXXXXXXXXVFAEMLIDNLYTTNK--DSMLFISCGXXXXXXXXXXXXT-ELRRRGNKSIDVILFVFWWMVFCGYF-FRYYSHFIALLQNSKPNRXXXXXXXXXXXXXXXXXXXXDTFLRFPPN--LRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFS-IISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSW-TRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQ-GLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMD-------------------------FGTEFK---------------------SFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQ-------GFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFS--LSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
++ W N+ N P TNC Q+T P++F + FS +L L+ ++ + +F + LR +L + V + + L+T + +++ F + A T R RG + VI + +V CG RYY L FA + + + L F P N + + PE AS +QLT++W Y K + + +DL+ +K+ I + N + +RR K + E+ I ++ +LI IF + +L +++ D+L P +L+ L+++ ++K + W GV A + + L+ S+ + F ++ + +R + + KTL LS EA+ + G I+N+ VD+++I + + + S P QI+L++ L+ LG S+ G +++ +IP I + +++ +KD+R+ +++EILNG+KV+K+Y WEKS + +R++E++ + S + + PFLV TF Y+ + P + +++ + F+A+ LFN ++ P+ + +Q + S R+ +F + E+ P++S+ T ++I++ G F+W ++ + L +I +++ +L+A+VGRVG GKSSLL A+LGEM L+G+VQ G +AYVPQ AWIQN +LRNNIL + ++ Y V++ C L D+ESLP D+TEIGE+G+NLSGGQKQRVSLARAVYQ+++I LLDD LSAVD +VG+ +F +IS G L KTRVL+THGL +L D++ V+ D+ ISE GTY+ LM+ FG + K S +++ +K D +I+ + + S S+ E E ++ + +E + +G+V + YF+A GI + L V +L F N++L +D + S N S + + + Y ++G+GQ +V G + AS+ +H+ LL+ ++RS + FF+ TP GRILNRF KD+ ID TL +I ++ +I+++ VI TPW GI + + Y ++ FY+S+SRQ +RL+S + S + +H E+ G+S IR+ F +D++ ++ RWL +RL+++GNLIV S AV R S LSA LVGLS+SYAL +T LNW R +E ETN V++ERI +YT+ P E N + + ++W NG I+++NFS++Y L VL +T +I+ EKIG+VGRTGAGKSSL LALFR++E G I IDG NI + L QLR +LTI+PQDPV+FSGT++ NLDPF ++DD++ ++L + + +V SL EG+++ G NLS+GQ+QLICLAR LL+K+K+++LDEA A+VD ETD + + I+ QF TV+ IAHRL T++D D+++ LD G + EF +PK+LLSN G F ++A+
Sbjct: 18 ETGWRNNS----NIPQVTNCGQHTDFSTIPTLFLVIFSPILFYELYKSRNSYLRSFSAISLRIIFCCLLVVDLTATVIYDFYL--LFTKSPLYNAIHFYGDLVQYAGFCLALVLTIACRNRGIITSGVITLYWLLVVVCGVPELRYY--ITGRLYKEYEIHSCRAALYVFAYVCSALELFLSCFADTPSNGYIGKNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAE---NIIPSFIENLIPEVEGYRRKIK----------KNPEAAIPKNHPSILIP-IFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQP-MWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQTSIAYGGTD----SAIKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDE-TISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNLYLARWSDDAKEIALSG-NGSSSETQIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDIEAIDQTLPHSIRAMVMTIFNVISTVFVIIWATPWAGIGFLVLGFVYFVVLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEG-NNSQSLAPKSWPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIFYSMAK 1529
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-1 (pep chromosome:WBcel235:X:576318:587483:-1 gene:WBGene00003407.1 transcript:F57C12.5e.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-1) HSP 1 Score: 788.875 bits (2036), Expect = 0.000e+0 Identity = 525/1544 (34.00%), Postives = 839/1544 (54.34%), Query Frame = 3
Query: 42 DSFWSNSHLQSPNYPIFTNCFQYTLLIIGPSIFFITFSILLLERLFNKKHLKIITFHSFDLRHSXXXXXXXXXXXXVFAEMLIDNLYTTNK--DSMLFISCGXXXXXXXXXXXXT-ELRRRGNKSIDVILFVFWWMVFCGYF-FRYYSHFIALLQNSKPNRXXXXXXXXXXXXXXXXXXXXDTFLRFPPN--LRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFS-IISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSW-TRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQ-GLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMD-------------------------FGTEFK---------------------SFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQ-------GFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPW--FGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFS--LSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
++ W N+ N P TNC Q+T P++F + FS +L L+ ++ + +F + LR +L + V + + L+T + +++ F + A T R RG + VI + +V CG RYY L FA + + + L F P N + + PE AS +QLT++W Y K + + +DL+ +K+ I + N + +RR K + E+ I ++ +LI IF + +L +++ D+L P +L+ L+++ ++K + W GV A + + L+ S+ + F ++ + +R + + KTL LS EA+ + G I+N+ VD+++I + + + S P QI+L++ L+ LG S+ G +++ +IP I + +++ +KD+R+ +++EILNG+KV+K+Y WEKS + +R++E++ + S + + PFLV TF Y+ + P + +++ + F+A+ LFN ++ P+ + +Q + S R+ +F + E+ P++S+ T ++I++ G F+W ++ + L +I +++ +L+A+VGRVG GKSSLL A+LGEM L+G+VQ G +AYVPQ AWIQN +LRNNIL + ++ Y V++ C L D+ESLP D+TEIGE+G+NLSGGQKQRVSLARAVYQ+++I LLDD LSAVD +VG+ +F +IS G L KTRVL+THGL +L D++ V+ D+ ISE GTY+ LM+ FG + K S +++ +K D +I+ + + S S+ E E ++ + +E + +G+V + YF+A GI + L V +L F N++L +D + S N S + + + Y ++G+GQ +V G + AS+ +H+ LL+ ++RS + FF+ TP GRILNRF KD+ ++D L NI D + L+ +V S TP+ F IV I I C+ +L+ FY+S+SRQ +RL+S + S + +H E+ G+S IR+ F +D++ ++ RWL +RL+++GNLIV S AV R S LSA LVGLS+SYAL +T LNW R +E ETN V++ERI +YT+ P E N + + ++W NG I+++NFS++Y L VL +T +I+ EKIG+VGRTGAGKSSL LALFR++E G I IDG NI + L QLR +LTI+PQDPV+FSGT++ NLDPF ++DD++ ++L + + +V SL EG+++ G NLS+GQ+QLICLAR LL+K+K+++LDEA A+VD ETD + + I+ QF TV+ IAHRL T++D D+++ LD G + EF +PK+LLSN G F ++A+
Sbjct: 18 ETGWRNNS----NIPQVTNCGQHTDFSTIPTLFLVIFSPILFYELYKSRNSYLRSFSAISLRIIFCCLLVVDLTATVIYDFYL--LFTKSPLYNAIHFYGDLVQYAGFCLALVLTIACRNRGIITSGVITLYWLLVVVCGVPELRYY--ITGRLYKEYEIHSCRAALYVFAYVCSALELFLSCFADTPSNGYIGKNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAE---NIIPSFIENLIPEVEGYRRKIK----------KNPEAAIPKNHPSILIP-IFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQP-MWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQTSIAYGGTD----SAIKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDE-TISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNLYLARWSDDAKEIALSG-NGSSSETQIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDMDVVDERLPDNIGDFLLTFSELVACVVFTSYATPFAIFPIVLIAI-GCFAILR-FYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEG-NNSQSLAPKSWPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIFYSMAK 1529
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-2 (pep chromosome:WBcel235:X:563719:572701:-1 gene:WBGene00003408.1 transcript:F57C12.4.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-2) HSP 1 Score: 788.489 bits (2035), Expect = 0.000e+0 Identity = 531/1548 (34.30%), Postives = 834/1548 (53.88%), Query Frame = 3
Query: 84 PIFTNCFQYTLLIIGPSIFFITFSILLLERLFNKKHLKIITFHSFDLRHSXXXXXXXXXXXXVFAEMLIDNLYTTNKDSMLFISCGXXXXXXXXXXXXTEL-------------RRRGNKSIDVILFVFWWMVFCGYF-FRYY-SHFIALLQNSKPNRXXXXXXXXXXXXXXXXXXXXDTFLRFPPNL--RETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFS-IISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQ-GLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLM---------------------------------------DFG-------TEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNEN-----AEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGI-----FVF---GSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQY----LSLRWLCLRLDILGNLIVFGSVIFAVLNRFS--LSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
P T C Q+T P++F + FS +++ +L + + ++ F R I++ +++D + T D L++S + + + +G + VI + +V CG FR+Y S FI N I A + + L F P ++ E+ PE AS ++LT++W Y K + ++ +DL+ +K+ + + N R D E+ N ++ S L + + IF + + +L ++ D+L P +LK L+ + ++K + W G + + S+F + + ++ + VR + + K L LS EA+ + G I+N+ VD+++I + + S P QI L++ L+ LG + G+ +++ +PV I +K +++ KD+R+ +++EILNG+KV+K+Y WE+S N + IR+ EL + S + + PFL +F Y+Y P + +++ E F+A+ LF+ +++P+ ++ + + VS R+ +F + E+ P++S+ + ++IE++NG FSW+ +P L+ I ++K +L+A+VG+VG GKSSLL A+LGEM L+G+VQ G IAYVPQ+AWIQN +LRNNIL K ++ Y V+ C L+ D+ +LP D+TEIGE+G+NLSGGQKQRVSLARAVYQ+ DI LLDD LSAVD +VG+ +F +IS+ G L KTRVLVTHGL +L D++ V+ +G ISE GTY+ L+ D G +S L++ SDK D + I+ S + R+ L + SQ + NE +E+ + + +E + +G+V + YF+A I F F GSS L G+L N +L L+D + + N++ + AK + Y ++G+GQ V++ G LRAS+ +H+ LL ++RS + FF+ TP GRILNR KD+ ID TL I + ++ +LVVI TPW GI + + Y ++ FYIS+SRQ +RL+S + S + +H E+ G+S IR+ +F + +D LI Y ++ RWL +RL+++GNLIV + AV R S LSA LVGLS+SYAL +T LNW R +E ETN VS+ERI++YT+ P E N + +++W G I+++NFS++Y L VL I+ +I EK+G+VGRTGAGKSSL LALFR++E G I IDG+NI ++ L QLR LTI+PQDPV+FSGT+K NLDPF Y+D ++ ++LE + + +V SL +G+ + G NLS+GQ+QLICLAR LL+K+K+++LDEA A+VD ETD + + I+ QF TV+ IAHRL T++D D+++ LD G + EF SPK LL+N G F ++A+
Sbjct: 28 PHVTKCGQHTDFSTIPTLFLVVFSFIVIYQLLHTRTAQLRCFSPISFR------------IILGCLLVVDLIATVIYDLYLYVSQSPNFEVVHFYGDLVQFGGICLALILTVACKNKGIITSGVITLYWLLVVVCGIPEFRFYLSGFI---YNEYALEGIRATLYIIAFTFSALELFLCCFADVPSDMYKSESSCPEYTASFINRLTFQWFTGLAYLGNKKSLENEDLWDLNEIDKAE---NLIPSFMQNLKPRID-----------EYHQNIKKDPSAALPKNHPSFVIPIFKTYKYTLLAGFFYKLCFDMLQFLAPQLLKQLIGFIEDKNQP-VWIGCSIVGIMFFSSFLQSMFLHQYYHSMFRLGMHVRSVLTSAVYSKALNLSNEARKGKTIGAIVNLMSVDIQKIQDMAPTIMLFWSAPLQIFLSIYFLWKFLGVAALAGLVVLILALPVNGLIAIQMRKCQTEQMKLKDERIKMMSEILNGMKVLKLYSWERSMENMVLKIRERELHILKKLSYFMAAIVFSWICAPFLASVISFVVYVYLDPENNVLTPEITFVALSLFDILRMPLAMVAMVYGEAVQCSVSNTRLKEFFAAEEMSPQTSI----SHGETDSAIEVENGLFSWSSDEDPTLREISFKIQKGQLVAIVGKVGSGKSSLLHALLGEMNKLSGSVQINGNIAYVPQQAWIQNMSLRNNILFNKPYDLENYEDVVKNCALKEDLANLPAGDRTEIGEKGINLSGGQKQRVSLARAVYQNPDIILLDDPLSAVDSHVGKHIFENVISSSTGCLASKTRVLVTHGLTYLKHCDQLIVLK-EGTISELGTYQELLNNSGAFAEFLEEFLIEESKTRGRVASIGDGSGEVDEILRDLGQVKPGILKRLESHLSQESDKEDTSARA-IEYSRDSSRRSVLLHSPRSQ-HEENEALLGAISEDVPAQENTQLIEKETVETGKVKFEVYIAYFQAISIPITLLFFFLYVGSSGL-----GILS---NFYLAKLSD-----HAKSGNRTSSDAKMELGIYAVLGMGQSFVVLIASIILTIGVLRASRILHAGLLGNIMRSPMAFFDVTPIGRILNRIGKDIEAIDRTLPDVIRHMSMTIFNVVATLVVIMWATPWAGIAFAILSVIYFIVLRFYISTSRQLKRLESASRSPIYSHFQESIQGASSIRAFGVVDNFIKQSQQRVDD----HLIAYYPSIVANRWLAVRLEMVGNLIVLSAAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVSVERIKEYTVTPTEG-NNSRRLAAKSWPEKGEISIKNFSVRYRPGLDLVLHGISAHIAPSEKVGIVGRTGAGKSSLTLALFRIIEADGGSIEIDGINIANLQLEQLRSCLTIVPQDPVLFSGTMKMNLDPFSAYSDSQVWEALENAHLKPFVKSLQDGLEHKISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLIQKTIREQFKECTVLTIAHRLNTVMDSDRLLVLDKGRVAEFDSPKNLLANPDGIFYSMAK 1520
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-1 (pep chromosome:WBcel235:X:576318:587483:-1 gene:WBGene00003407.1 transcript:F57C12.5b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-1) HSP 1 Score: 785.793 bits (2028), Expect = 0.000e+0 Identity = 521/1542 (33.79%), Postives = 831/1542 (53.89%), Query Frame = 3
Query: 42 DSFWSNSHLQSPNYPIFTNCFQYTLLIIGPSIFFITFSILLLERLFNKKHLKIITFHSFDLRHSXXXXXXXXXXXXVFAEMLIDNLYTTNK--DSMLFISCGXXXXXXXXXXXXT-ELRRRGNKSIDVILFVFWWMVFCGYF-FRYYSHFIALLQNSKPNRXXXXXXXXXXXXXXXXXXXXDTFLRFPPN--LRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFS-IISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSW-TRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQ-GLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMD-------------------------FGTEFK---------------------SFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQ-------GFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFS--LSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
++ W N+ N P TNC Q+T P++F + FS +L L+ ++ + +F + LR +L + V + + L+T + +++ F + A T R RG + VI + +V CG RYY L FA + + + L F P N + + PE AS +QLT++W Y K + + +DL+ +K+ I + N + +RR K + E+ I ++ +LI IF + +L +++ D+L P +L+ L+++ ++K + W GV A + + L+ S+ + F ++ + +R + + KTL LS EA+ + G I+N+ VD+++I + + + S P QI+L++ L+ LG S+ G +++ +IP I + +++ +KD+R+ +++EILNG+KV+K+Y WEKS + +R++E++ + S + + PFLV TF Y+ + P + +++ + F+A+ LFN ++ P+ + +Q + S R+ +F + E+ P++S+ T ++I++ G F+W ++ + L +I +++ +L+A+VGRVG GKSSLL A+LGEM L+G+VQ G +AYVPQ AWIQN +LRNNIL + ++ Y V++ C L D+ESLP D+TEIGE+G+NLSGGQKQRVSLARAVYQ+++I LLDD LSAVD +VG+ +F +IS G L KTRVL+THGL +L D++ V+ D+ ISE GTY+ LM+ FG + K S +++ +K D +I+ + + S S+ E E ++ + +E + +G+V + YF+A GI + L V +L F N++L +D + S N S + + + Y ++G+GQ +V G + AS+ +H+ LL+ ++RS + FF+ TP GRILNRF KD+ +ID+ L I + V +T V TP +LI Y L FY+S+SRQ +RL+S + S + +H E+ G+S IR+ F +D++ ++ RWL +RL+++GNLIV S AV R S LSA LVGLS+SYAL +T LNW R +E ETN V++ERI +YT+ P E N + + ++W NG I+++NFS++Y L VL +T +I+ EKIG+VGRTGAGKSSL LALFR++E G I IDG NI + L QLR +LTI+PQDPV+FSGT++ NLDPF ++DD++ ++L + + +V SL EG+++ G NLS+GQ+QLICLAR LL+K+K+++LDEA A+VD ETD + + I+ QF TV+ IAHRL T++D D+++ LD G + EF +PK+LLSN G F ++A+
Sbjct: 18 ETGWRNNS----NIPQVTNCGQHTDFSTIPTLFLVIFSPILFYELYKSRNSYLRSFSAISLRIIFCCLLVVDLTATVIYDFYL--LFTKSPLYNAIHFYGDLVQYAGFCLALVLTIACRNRGIITSGVITLYWLLVVVCGVPELRYY--ITGRLYKEYEIHSCRAALYVFAYVCSALELFLSCFADTPSNGYIGKNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAE---NIIPSFIENLIPEVEGYRRKIK----------KNPEAAIPKNHPSILIP-IFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQP-MWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQTSIAYGGTD----SAIKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDE-TISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNLYLARWSDDAKEIALSG-NGSSSETQIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDIDVIDYRLPSCIMTFVGAIVQAVTIFAVPIYATPLSSFPITIVLIGYYFLLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEG-NNSQSLAPKSWPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIFYSMAK 1529
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-1 (pep chromosome:WBcel235:X:576318:587483:-1 gene:WBGene00003407.1 transcript:F57C12.5d.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-1) HSP 1 Score: 782.326 bits (2019), Expect = 0.000e+0 Identity = 518/1542 (33.59%), Postives = 834/1542 (54.09%), Query Frame = 3
Query: 42 DSFWSNSHLQSPNYPIFTNCFQYTLLIIGPSIFFITFSILLLERLFNKKHLKIITFHSFDLRHSXXXXXXXXXXXXVFAEMLIDNLYTTNK--DSMLFISCGXXXXXXXXXXXXT-ELRRRGNKSIDVILFVFWWMVFCGYF-FRYYSHFIALLQNSKPNRXXXXXXXXXXXXXXXXXXXXDTFLRFPPN--LRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFS-IISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSW-TRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQ-GLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMD-------------------------FGTEFK---------------------SFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQ-------GFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFS--LSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
++ W N+ N P TNC Q+T P++F + FS +L L+ ++ + +F + LR +L + V + + L+T + +++ F + A T R RG + VI + +V CG RYY L FA + + + L F P N + + PE AS +QLT++W Y K + + +DL+ +K+ I + N + +RR K + E+ I ++ +LI IF + +L +++ D+L P +L+ L+++ ++K + W GV A + + L+ S+ + F ++ + +R + + KTL LS EA+ + G I+N+ VD+++I + + + S P QI+L++ L+ LG S+ G +++ +IP I + +++ +KD+R+ +++EILNG+KV+K+Y WEKS + +R++E++ + S + + PFLV TF Y+ + P + +++ + F+A+ LFN ++ P+ + +Q + S R+ +F + E+ P++S+ T ++I++ G F+W ++ + L +I +++ +L+A+VGRVG GKSSLL A+LGEM L+G+VQ G +AYVPQ AWIQN +LRNNIL + ++ Y V++ C L D+ESLP D+TEIGE+G+NLSGGQKQRVSLARAVYQ+++I LLDD LSAVD +VG+ +F +IS G L KTRVL+THGL +L D++ V+ D+ ISE GTY+ LM+ FG + K S +++ +K D +I+ + + S S+ E E ++ + +E + +G+V + YF+A GI + L V +L F N++L +D + S N S + + + Y ++G+GQ +V G + AS+ +H+ LL+ ++RS + FF+ TP GRILNRF KD+ +D + ++ I V I + +I TP + +P+ I Y ++ FY+S+SRQ +RL+S + S + +H E+ G+S IR+ F +D++ ++ RWL +RL+++GNLIV S AV R S LSA LVGLS+SYAL +T LNW R +E ETN V++ERI +YT+ P E N + + ++W NG I+++NFS++Y L VL +T +I+ EKIG+VGRTGAGKSSL LALFR++E G I IDG NI + L QLR +LTI+PQDPV+FSGT++ NLDPF ++DD++ ++L + + +V SL EG+++ G NLS+GQ+QLICLAR LL+K+K+++LDEA A+VD ETD + + I+ QF TV+ IAHRL T++D D+++ LD G + EF +PK+LLSN G F ++A+
Sbjct: 18 ETGWRNNS----NIPQVTNCGQHTDFSTIPTLFLVIFSPILFYELYKSRNSYLRSFSAISLRIIFCCLLVVDLTATVIYDFYL--LFTKSPLYNAIHFYGDLVQYAGFCLALVLTIACRNRGIITSGVITLYWLLVVVCGVPELRYY--ITGRLYKEYEIHSCRAALYVFAYVCSALELFLSCFADTPSNGYIGKNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAE---NIIPSFIENLIPEVEGYRRKIK----------KNPEAAIPKNHPSILIP-IFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQP-MWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQTSIAYGGTD----SAIKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDE-TISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNLYLARWSDDAKEIALSG-NGSSSETQIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDVDGVDTDIPRTMSMFIRTAVSSIEIIAIILWATPLAISLLLPLFIVYFVVLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEG-NNSQSLAPKSWPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIFYSMAK 1529
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090026) HSP 1 Score: 858.21 bits (2216), Expect = 0.000e+0 Identity = 508/1344 (37.80%), Postives = 780/1344 (58.04%), Query Frame = 3
Query: 606 ETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGE--REDIFRRASKSEDEEFLINSEEKESFILEHSGK-----VLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPV-LKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL------------------------------------------NES-SDKVD-KNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESI--NETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
E + PE+ AS S++TY+W D Y+ + +K +DL + S E+ + H++ + R++ +A +F + E+ E +G+ ++ I+ + + L L+++ D L P VL L++++ + + WKG+LYA + + + F + +R+R ++I I RK LR+S K + G+I+N+ VD ++ M Y ++ S P QI L + L+ +LG S+ G+A+++ +IPV I K Y +++ +KD+R+ ++ E+L+GIKV+K+Y WE SF ++ IR +E+ R+ + + ++ PFLV TF Y+ +++ A K F+++ LFN ++ P+ +LP +T + VS RI KFL S E+ P S V+ S + I+NG FSW G+ + L+NI + V+K L+A+VG VG GKSS++ A LGEM L G V T GK+AYVPQ+AWIQN T+R+NIL +++++ Y KV+DAC L DI+ L D TEIGE+G+NLSGGQKQR+SLARAVY D+D+YLLDD LSAVD +VG+ +F ++I +G+L K+RVLVTHG+ +LP VD I VI G+ISE GT++ L+ F F+ ES SD + + ++L+ +R+ R + S + ++ E + E+ +G V Y K+ GIF+ ++++ +F Q N+WL A+ Q++ N++ Y+ YG G GQ++ L G + +++ +H+VLL LR ++ F+ TP GRI+NRF+KD+ ID+TL LN+ +I + ++ ++VVIS+ TP F V +PI Y Q FY+++SRQ RL+S + S + +H ET +G+S IR+ F +DK+ K ++ RWL +RL+++GNLI+ + +FAVL + LVGLS+SYALQVT LNWL R ++ ETN VS+ERI++Y E+ E + +NW G + +NF ++Y L VL+ ++ NI GGEK+G+VGRTGAGKSSL LALFR++E GRI IDGV+I S+GLH LR +LTI+PQDPV+FSG+L+ NLDPF+ TDD++ K+LE+S + +V SL G+N++ G NLS+GQ+QL+CLAR LL+K+K+++LDEATA+VD ETD + + I+ +F TV+ IAHRL TI+D DK+I LD G IIEF SP ELL N F ++A+
Sbjct: 221 ENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCS---EVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFLNSEELDPNS----VLHDSSKPHPMSIENGEFSW---GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIK-MGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVE---GKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRD------MYLGVYGAFGFGQVVTGYLSTLILSLGCVYSARYMHNVLLHGTLRWPMEMFDITPLGRIVNRFSKDVDTIDNTLPLNLRVVILQLFAVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGG-QTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1543 HSP 2 Score: 80.1073 bits (196), Expect = 1.441e-14 Identity = 118/511 (23.09%), Postives = 216/511 (42.27%), Query Frame = 3
Query: 3036 KIHSVLLDTVLRSTLQFFNATPS----GRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFG-------IVGIPILICYILLQVFYISSSR----QARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKS-NKFKLIQYL----SLRWLCLRLDILGNLIVFGS-VIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKH 4496
+I + L++ + R L+ N+T G I+N L +D + +T +N ++ ++ + I + + + G+ ++I IL+ V + +SR Q R++ K L + E SG +++ E FE DK + YL S W C L +L+ F + V+ N + + V LS+ L+ L L VS+ RI ++ + S N + + +++EN + + L+NI I + G + +VG G+GKSS+ A +E +G + N++G +L +PQ I + T++ N+ Y + K ++ + ++ L+ G + G G NLS GQKQ I LAR + + + +LD+ ++VD + + E + K + +++ H + + D I + G I E G+ +L+ N G F AD I+H
Sbjct: 403 RIRTALINAIYRKALRISNSTKKESTVGEIVN-----LMAVDAQRFMELTTYLN---MIWSAPLQIGLALYFLWQQLGPSVLAGLAVMI--ILIPVNGVIASRIKTYQIRQMKYKDERVKLMN--EVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCA--PFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFP--LTMLPMLITNLVQTQVSVNRINKF----LNSEELDPNSVLHDSSKPHPMSIENGEFSWGDEI--TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV-------NTVG------KLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKN-KGAF-----ADFIIQH 872
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090025) HSP 1 Score: 856.284 bits (2211), Expect = 0.000e+0 Identity = 508/1344 (37.80%), Postives = 774/1344 (57.59%), Query Frame = 3
Query: 606 ETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGE--REDIFRRASKSEDEEFLINSEEKESFILEHSGK-----VLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPV-LKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL------------------------------------------NES-SDKVD-KNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESI--NETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
E + PE+ AS S++TY+W D Y+ + +K +DL + S E+ + H++ + R++ +A +F + E+ E +G+ ++ I+ + + L L+++ D L P VL L++++ + + WKG+LYA + + + F + +R+R ++I I RK LR+S K + G+I+N+ VD ++ M Y ++ S P QI L + L+ +LG S+ G+A+++ +IPV I K Y +++ +KD+R+ ++ E+L+GIKV+K+Y WE SF ++ IR +E+ R+ + + ++ PFLV TF Y+ +++ A K F+++ LFN ++ P+ +LP +T + VS RI KFL S E+ P S V+ S + I+NG FSW G+ + L+NI + V+K L+A+VG VG GKSS++ A LGEM L G V T GK+AYVPQ+AWIQN T+R+NIL +++++ Y KV+DAC L DI+ L D TEIGE+G+NLSGGQKQR+SLARAVY D+D+YLLDD LSAVD +VG+ +F ++I +G+L K+RVLVTHG+ +LP VD I VI G+ISE GT++ L+ F F+ ES SD + + ++L+ +R+ R + S + ++ E + E+ +G V Y K+ GIF+ ++++ +F Q N+WL A+ Q++ N++ Y+ YG G GQ G L A+K +HS+LL+ VLR+ + F+ TP GRIL+RF+KD+ +D + I D I ++ ++VVIS+ TP F V +PI Y Q FY+++SRQ RL+S + S + +H ET +G+S IR+ F +DK+ K ++ RWL +RL+++GNLI+ + +FAVL + LVGLS+SYALQVT LNWL R ++ ETN VS+ERI++Y E+ E + +NW G + +NF ++Y L VL+ ++ NI GGEK+G+VGRTGAGKSSL LALFR++E GRI IDGV+I S+GLH LR +LTI+PQDPV+FSG+L+ NLDPF+ TDD++ K+LE+S + +V SL G+N++ G NLS+GQ+QL+CLAR LL+K+K+++LDEATA+VD ETD + + I+ +F TV+ IAHRL TI+D DK+I LD G IIEF SP ELL N F ++A+
Sbjct: 221 ENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCS---EVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFLNSEELDPNS----VLHDSSKPHPMSIENGEFSW---GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIK-MGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVE---GKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRD------MYLGVYGAFGFGQGFTSFFSDLAPALGSLHAAKVLHSMLLENVLRAPMTMFDTTPVGRILSRFSKDVESVDQKMPQVINDCIWCAFEVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGG-QTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1543 HSP 2 Score: 80.1073 bits (196), Expect = 1.720e-14 Identity = 118/511 (23.09%), Postives = 216/511 (42.27%), Query Frame = 3
Query: 3036 KIHSVLLDTVLRSTLQFFNATPS----GRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFG-------IVGIPILICYILLQVFYISSSR----QARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKS-NKFKLIQYL----SLRWLCLRLDILGNLIVFGS-VIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKH 4496
+I + L++ + R L+ N+T G I+N L +D + +T +N ++ ++ + I + + + G+ ++I IL+ V + +SR Q R++ K L + E SG +++ E FE DK + YL S W C L +L+ F + V+ N + + V LS+ L+ L L VS+ RI ++ + S N + + +++EN + + L+NI I + G + +VG G+GKSS+ A +E +G + N++G +L +PQ I + T++ N+ Y + K ++ + ++ L+ G + G G NLS GQKQ I LAR + + + +LD+ ++VD + + E + K + +++ H + + D I + G I E G+ +L+ N G F AD I+H
Sbjct: 403 RIRTALINAIYRKALRISNSTKKESTVGEIVN-----LMAVDAQRFMELTTYLN---MIWSAPLQIGLALYFLWQQLGPSVLAGLAVMI--ILIPVNGVIASRIKTYQIRQMKYKDERVKLMN--EVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPF--LVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFP--LTMLPMLITNLVQTQVSVNRINKF----LNSEELDPNSVLHDSSKPHPMSIENGEFSWGDEI--TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV-------NTVG------KLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKN-KGAF-----ADFIIQH 872
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090022) HSP 1 Score: 855.514 bits (2209), Expect = 0.000e+0 Identity = 507/1344 (37.72%), Postives = 775/1344 (57.66%), Query Frame = 3
Query: 606 ETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGE--REDIFRRASKSEDEEFLINSEEKESFILEHSGK-----VLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPV-LKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL------------------------------------------NES-SDKVD-KNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESI--NETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
E + PE+ AS S++TY+W D Y+ + +K +DL + S E+ + H++ + R++ +A +F + E+ E +G+ ++ I+ + + L L+++ D L P VL L++++ + + WKG+LYA + + + F + +R+R ++I I RK LR+S K + G+I+N+ VD ++ M Y ++ S P QI L + L+ +LG S+ G+A+++ +IPV I K Y +++ +KD+R+ ++ E+L+GIKV+K+Y WE SF ++ IR +E+ R+ + + ++ PFLV TF Y+ +++ A K F+++ LFN ++ P+ +LP +T + VS RI KFL S E+ P S V+ S + I+NG FSW G+ + L+NI + V+K L+A+VG VG GKSS++ A LGEM L G V T GK+AYVPQ+AWIQN T+R+NIL +++++ Y KV+DAC L DI+ L D TEIGE+G+NLSGGQKQR+SLARAVY D+D+YLLDD LSAVD +VG+ +F ++I +G+L K+RVLVTHG+ +LP VD I VI G+ISE GT++ L+ F F+ ES SD + + ++L+ +R+ R + S + ++ E + E+ +G V Y K+ GIF+ ++++ +F Q N+WL A+ Q++ N++ Y+ YG G GQ+ G L+ S+ +H LL LR ++ F+ TP GRI+NRF+KD+ ID+ L NI +I + +++ ++VVIS+ TP F V +PI Y Q FY+++SRQ RL+S + S + +H ET +G+S IR+ F +DK+ K ++ RWL +RL+++GNLI+ + +FAVL + LVGLS+SYALQVT LNWL R ++ ETN VS+ERI++Y E+ E + +NW G + +NF ++Y L VL+ ++ NI GGEK+G+VGRTGAGKSSL LALFR++E GRI IDGV+I S+GLH LR +LTI+PQDPV+FSG+L+ NLDPF+ TDD++ K+LE+S + +V SL G+N++ G NLS+GQ+QL+CLAR LL+K+K+++LDEATA+VD ETD + + I+ +F TV+ IAHRL TI+D DK+I LD G IIEF SP ELL N F ++A+
Sbjct: 221 ENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCS---EVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFLNSEELDPNS----VLHDSSKPHPMSIENGEFSW---GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIK-MGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVE---GKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRD------MYLGVYGAFGFGQVATNFFSSLAISLGCLKCSQLLHQTLLYYNLRWPMELFDTTPLGRIVNRFSKDIDTIDNVLPFNIRVVIGQAYMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGG-QTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1543 HSP 2 Score: 80.1073 bits (196), Expect = 1.649e-14 Identity = 118/511 (23.09%), Postives = 216/511 (42.27%), Query Frame = 3
Query: 3036 KIHSVLLDTVLRSTLQFFNATPS----GRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFG-------IVGIPILICYILLQVFYISSSR----QARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKS-NKFKLIQYL----SLRWLCLRLDILGNLIVFGS-VIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKH 4496
+I + L++ + R L+ N+T G I+N L +D + +T +N ++ ++ + I + + + G+ ++I IL+ V + +SR Q R++ K L + E SG +++ E FE DK + YL S W C L +L+ F + V+ N + + V LS+ L+ L L VS+ RI ++ + S N + + +++EN + + L+NI I + G + +VG G+GKSS+ A +E +G + N++G +L +PQ I + T++ N+ Y + K ++ + ++ L+ G + G G NLS GQKQ I LAR + + + +LD+ ++VD + + E + K + +++ H + + D I + G I E G+ +L+ N G F AD I+H
Sbjct: 403 RIRTALINAIYRKALRISNSTKKESTVGEIVN-----LMAVDAQRFMELTTYLN---MIWSAPLQIGLALYFLWQQLGPSVLAGLAVMI--ILIPVNGVIASRIKTYQIRQMKYKDERVKLMN--EVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCA--PFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFP--LTMLPMLITNLVQTQVSVNRINKF----LNSEELDPNSVLHDSSKPHPMSIENGEFSWGDEI--TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV-------NTVG------KLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKN-KGAF-----ADFIIQH 872
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090017) HSP 1 Score: 854.744 bits (2207), Expect = 0.000e+0 Identity = 509/1344 (37.87%), Postives = 778/1344 (57.89%), Query Frame = 3
Query: 606 ETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGE--REDIFRRASKSEDEEFLINSEEKESFILEHSGK-----VLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPV-LKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL------------------------------------------NES-SDKVD-KNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESI--NETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
E + PE+ AS S++TY+W D Y+ + +K +DL + S E+ + H++ + R++ +A +F + E+ E +G+ ++ I+ + + L L+++ D L P VL L++++ + + WKG+LYA + + + F + +R+R ++I I RK LR+S K + G+I+N+ VD ++ M Y ++ S P QI L + L+ +LG S+ G+A+++ +IPV I K Y +++ +KD+R+ ++ E+L+GIKV+K+Y WE SF ++ IR +E+ R+ + + ++ PFLV TF Y+ + +S EKV ++I LF+ ++LP+ +LP VS RI KFL S E+ P S V+ S + I+NG FSW G+ + L+NI + V+K L+A+VG VG GKSS++ A LGEM L G V T GK+AYVPQ+AWIQN T+R+NIL +++++ Y KV+DAC L DI+ L D TEIGE+G+NLSGGQKQR+SLARAVY D+D+YLLDD LSAVD +VG+ +F ++I +G+L K+RVLVTHG+ +LP VD I VI G+ISE GT++ L+ F F+ ES SD + + ++L+ +R+ R + S + ++ E + E+ +G V Y K+ GIF+ ++++ +F Q N+WL A+ Q++ N++ Y+ YG G GQ++ L G + +++ +H+VLL LR ++ F+ TP GRI+NRF+KD+ ID+TL LN+ +I + ++ ++VVIS+ TP F V +PI Y Q FY+++SRQ RL+S + S + +H ET +G+S IR+ F +DK+ K ++ RWL +RL+++GNLI+ + +FAVL + LVGLS+SYALQVT LNWL R ++ ETN VS+ERI++Y E+ E + +NW G + +NF ++Y L VL+ ++ NI GGEK+G+VGRTGAGKSSL LALFR++E GRI IDGV+I S+GLH LR +LTI+PQDPV+FSG+L+ NLDPF+ TDD++ K+LE+S + +V SL G+N++ G NLS+GQ+QL+CLAR LL+K+K+++LDEATA+VD ETD + + I+ +F TV+ IAHRL TI+D DK+I LD G IIEF SP ELL N F ++A+
Sbjct: 221 ENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCS---EVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNS----VLHDSSKPHPMSIENGEFSW---GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIK-MGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVE---GKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRD------MYLGVYGAFGFGQVVTGYLSTLILSLGCVYSARYMHNVLLHGTLRWPMEMFDITPLGRIVNRFSKDVDTIDNTLPLNLRVVILQLFAVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGG-QTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1543 HSP 2 Score: 85.5001 bits (210), Expect = 3.985e-16 Identity = 120/512 (23.44%), Postives = 225/512 (43.95%), Query Frame = 3
Query: 3036 KIHSVLLDTVLRSTLQFFNATPS----GRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFG-------IVGIPILICYILLQVFYISSSR----QARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKS-NKFKLIQYL----SLRWLCLRLDILGNLIVFGS-VIFAVLNRFSLSASLVGLSISYALQVT-GILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKH 4496
+I + L++ + R L+ N+T G I+N L +D + +T +N ++ ++ + I + + + G+ ++I IL+ V + +SR Q R++ K L + E SG +++ E FE DK + YL S W C L +L+ F + V+ + N+ S+ LV +++ +++ IL L+ AE + VS+ RI ++ + S N + + +++EN + + L+NI I + G + +VG G+GKSS+ A +E +G + N++G +L +PQ I + T++ N+ Y + K ++ + ++ L+ G + G G NLS GQKQ I LAR + + + +LD+ ++VD + + E + K + +++ H + + D I + G I E G+ +L+ N G F AD I+H
Sbjct: 403 RIRTALINAIYRKALRISNSTKKESTVGEIVN-----LMAVDAQRFMELTTYLN---MIWSAPLQIGLALYFLWQQLGPSVLAGLAVMI--ILIPVNGVIASRIKTYQIRQMKYKDERVKLMN--EVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCA--PFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQ---VSVNRINKF----LNSEELDPNSVLHDSSKPHPMSIENGEFSWGDEI--TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV-------NTVG------KLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKN-KGAF-----ADFIIQH 872
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090020) HSP 1 Score: 852.818 bits (2202), Expect = 0.000e+0 Identity = 509/1344 (37.87%), Postives = 772/1344 (57.44%), Query Frame = 3
Query: 606 ETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGE--REDIFRRASKSEDEEFLINSEEKESFILEHSGK-----VLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPV-LKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL------------------------------------------NES-SDKVD-KNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESI--NETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
E + PE+ AS S++TY+W D Y+ + +K +DL + S E+ + H++ + R++ +A +F + E+ E +G+ ++ I+ + + L L+++ D L P VL L++++ + + WKG+LYA + + + F + +R+R ++I I RK LR+S K + G+I+N+ VD ++ M Y ++ S P QI L + L+ +LG S+ G+A+++ +IPV I K Y +++ +KD+R+ ++ E+L+GIKV+K+Y WE SF ++ IR +E+ R+ + + ++ PFLV TF Y+ + +S EKV ++I LF+ ++LP+ +LP VS RI KFL S E+ P S V+ S + I+NG FSW G+ + L+NI + V+K L+A+VG VG GKSS++ A LGEM L G V T GK+AYVPQ+AWIQN T+R+NIL +++++ Y KV+DAC L DI+ L D TEIGE+G+NLSGGQKQR+SLARAVY D+D+YLLDD LSAVD +VG+ +F ++I +G+L K+RVLVTHG+ +LP VD I VI G+ISE GT++ L+ F F+ ES SD + + ++L+ +R+ R + S + ++ E + E+ +G V Y K+ GIF+ ++++ +F Q N+WL A+ Q++ N++ Y+ YG G GQ G L A+K +HS+LL+ VLR+ + F+ TP GRIL+RF+KD+ +D + I D I ++ ++VVIS+ TP F V +PI Y Q FY+++SRQ RL+S + S + +H ET +G+S IR+ F +DK+ K ++ RWL +RL+++GNLI+ + +FAVL + LVGLS+SYALQVT LNWL R ++ ETN VS+ERI++Y E+ E + +NW G + +NF ++Y L VL+ ++ NI GGEK+G+VGRTGAGKSSL LALFR++E GRI IDGV+I S+GLH LR +LTI+PQDPV+FSG+L+ NLDPF+ TDD++ K+LE+S + +V SL G+N++ G NLS+GQ+QL+CLAR LL+K+K+++LDEATA+VD ETD + + I+ +F TV+ IAHRL TI+D DK+I LD G IIEF SP ELL N F ++A+
Sbjct: 221 ENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCS---EVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNS----VLHDSSKPHPMSIENGEFSW---GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIK-MGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVE---GKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRD------MYLGVYGAFGFGQGFTSFFSDLAPALGSLHAAKVLHSMLLENVLRAPMTMFDTTPVGRILSRFSKDVESVDQKMPQVINDCIWCAFEVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGG-QTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1543 HSP 2 Score: 85.5001 bits (210), Expect = 4.053e-16 Identity = 120/512 (23.44%), Postives = 225/512 (43.95%), Query Frame = 3
Query: 3036 KIHSVLLDTVLRSTLQFFNATPS----GRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFG-------IVGIPILICYILLQVFYISSSR----QARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKS-NKFKLIQYL----SLRWLCLRLDILGNLIVFGS-VIFAVLNRFSLSASLVGLSISYALQVT-GILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKH 4496
+I + L++ + R L+ N+T G I+N L +D + +T +N ++ ++ + I + + + G+ ++I IL+ V + +SR Q R++ K L + E SG +++ E FE DK + YL S W C L +L+ F + V+ + N+ S+ LV +++ +++ IL L+ AE + VS+ RI ++ + S N + + +++EN + + L+NI I + G + +VG G+GKSS+ A +E +G + N++G +L +PQ I + T++ N+ Y + K ++ + ++ L+ G + G G NLS GQKQ I LAR + + + +LD+ ++VD + + E + K + +++ H + + D I + G I E G+ +L+ N G F AD I+H
Sbjct: 403 RIRTALINAIYRKALRISNSTKKESTVGEIVN-----LMAVDAQRFMELTTYLN---MIWSAPLQIGLALYFLWQQLGPSVLAGLAVMI--ILIPVNGVIASRIKTYQIRQMKYKDERVKLMN--EVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPF--LVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQ---VSVNRINKF----LNSEELDPNSVLHDSSKPHPMSIENGEFSWGDEI--TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVV-------NTVG------KLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKN-KGAF-----ADFIIQH 872
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Source:ZFIN;Acc:ZDB-GENE-050517-15]) HSP 1 Score: 833.943 bits (2153), Expect = 0.000e+0 Identity = 503/1326 (37.93%), Postives = 780/1326 (58.82%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSE--DEEFLINSEEKESFILEHSGKVLIKSI---------------FGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLY-AFVFL---IQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL----NESSDKVDKNQNNLIQ--------PSAPNKRKRSRLSTSGS----QGFDGNENAEENYEKYF--NDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGV--LQAFG-NVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES-INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFK 4463
PE AS S++T+ W+ + YK + +K + L++ +KS + Q + + +R + E+K+ +E S +L K++ FG +F L++ L +I+ D+L+ P +L+LL+ + + TW G Y A +F+ +Q LI + + CF +R+R +++G + RK L ++ A+ T + G+I+N+ VD ++ M+ I Y ++ S P Q+IL + L+ LG S+ GVA++V ++P+ I TK Y ++ KD R+ ++ E+LNGIKV+K+Y WE +F K+ +IR+ EL+ + + I + PFLV STF Y+ +I+ A+K F+++ LFN ++ P+ +LP ++ + A VS R+ + LS+E +V +P SI I +G FSW++ P LK I +++ + L+AVVG VG GKSSLLSA+LGEM+ G+V +G +AYVPQ+AWIQN TL++NIL + +Y KV++AC L D+E LP D TEIGE+GVNLSGGQKQRVS+ARAVY + +YLLDD LSAVD +VG+ +F K+I QGLL+ +TRVLVTHGL +LP D I V+ D G+I+E G+Y L+ F FL N ++ +++ + + P+A ++ + L+ +G+ Q + N++A K + ++ ++ +GRV L S+ W Y KA G+ + SI + +F L + G N WL + D + N ++ + + YG +G+ Q +AV + GG+ AS+ +H +L VLRS + FF TPSG ++NRF K+ ID + I + ++ S VI I TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V TH ET G+S+IR+ + F +D + K ++ RWL +RL+ +GN IV + +FAV+ R +LS ++GLSISYALQVT LNWL R +E ETN V++ER+++Y E+ N+ + W + G+I + F L+Y +L + +I++NI GGEK+G+VGRTGAGKSSL L LFR++E G I IDGVNI +GLH+LR ++TI+PQDPV+FSG+L+ NLDPFD YTD+++ +SLE++ + +V+ L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D +++ LD G + EF SP L++ +K
Sbjct: 209 PESGASFLSKITFWWITGLMVKGYKRPLEEKDLWSLNNEDKSE---RVVPQLVRRWDQECVKVKRPVDKTLYSPKRSTRGEKKDGQPVEESEILLAKALQKTGEPSLFFALCRTFGPYF---LVSSLYKIIHDVLMFVGPEILRLLILFVNDSSAP-TWHGYFYTALLFVCTCLQTLILQKYFHVCFV----TGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGASVLAGVAVMVLMVPLNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKGKVSAIRESELRVLKKMAYLGAISTFTWVCAPFLVALSTFAVYVLVDENNILDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMQRL-RVFLSHEELDDDNVERPAISGTPD-SIRIADGAFSWSKDDPPTLKRINVSIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGSVSIKGSVAYVPQQAWIQNATLKDNILFGRETKDSWYQKVVEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGLLQGRTRVLVTHGLSFLPQADLILVMVD-GEITEMGSYTELLGRQGAFAEFLRTYTNTEQEEGEESLGDAVPRKGLENGGPAALLRQSQISLNATGAGKTTQKTEANDDAAATKTKSAEASRLTEADKANTGRVKL-SVFWEYMKAIGLPL---SIFSIFLFFCHHLSSLGSNYWLSLWTD------DPVVNNTQPKREMRLGVYGALGISQGIAVFCYSVSVSVGGILASRYLHQTMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQMKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIKESDGRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVMARNNLSPGIMGLSISYALQVTASLNWLVRMSSELETNIVAVERVKEYGDTEKEAEWKLENSNLPPGWPTAGHIEIHKFGLRYREDLELAICDISVNIAGGEKVGIVGRTGAGKSSLTLGLFRIIEAAEGEIRIDGVNIADLGLHELRSRITIIPQDPVLFSGSLRMNLDPFDGYTDEEVWRSLELAHLKTFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGQMAEFDSPSNLIAKKGIFYK 1510
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 2 [Source:ZFIN;Acc:ZDB-GENE-040426-1523]) HSP 1 Score: 829.706 bits (2142), Expect = 0.000e+0 Identity = 505/1372 (36.81%), Postives = 792/1372 (57.73%), Query Frame = 3
Query: 615 HPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRAS--------------KSEDEEFLINSEEKESFILE---------------------HSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSA---PNKRKRSRLSTSGSQGFDGN-ENAEENYEKYFNDISH----------------------------------EEEIM-SGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTF-NQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHEDK 4505
+PE A+ S++T+ W +S ++ +K + + +DL+ + ++ Q F + +E ++A +E + L ++ ++E + L+ +I + ++L + L ++++D+L P +LKL++ F + + +Y W G LYA + ++ + SV F + ++VR +++ + +K L +S +++ +AG+I+N+ D ++ + + +L SCP QI L++ L+ ELG S+ G+ ++V ++P+ + ++++ + + +KD RM I+ ++LNGIK++K Y WE SF +++ IR++ELK R ++ + +F P LV +TF ++ P +I+ AEK F +I LFN ++ P+ +LP ++ + VS R+ KFL +++ V S A++ + NG ++W R PVLK + L ++ +L+AVVG VG GK+SL+SA+LGE++++ G + G +AYVPQ+AWIQN TL++NIL S ++ Y V+ AC LE D++ LP RDQTEIGE+G+NLSGGQKQRVSLARAVY +D+YLLDD LSAVD +VG+ LF K+I GLL+ KTR+LVTHG+ +LP+VDEI V+ G +SE G+YE L F FL E+ K + N++N + +A P + L DG+ E+ + K N + H E+E+M +GRV + + Y A G + G S + I V N+WL D N T+ N R++ I +G +GL Q V G + AS+ +H+ LL +L+ + FF+ TPSGRI+NRF KD+F +D + ++ I + ++ +L VI + TP F V +P+ + Y +Q FY+++SRQ RRLDS + S + +H ET SG S+IR+ + F ID++ K +S RWL +RL+ LGNL+VF + +FAV++R SL++ LVGLSISYAL VT LNWL R +E ETN V++ER+R+Y I E+ T+ ++W S GNI E++ ++Y L VL +T +I EKIG+VGRTGAGKSSL LFR+VE GRI ID ++I ++GLH LR +LTI+PQDPV+FSGTL+ NLDPF ++D ++ LE++ + ++V L G+ ++ G NLS+GQ+QL+CLAR LL+KS+I+ILDEATA+VD ETD + I+ +F TV+ IAHRL TI+D +++ LD G I+EF SP ELLS GHF ++A+ D I+ E++
Sbjct: 207 NPEAKATFLSRITFNWFNSMVWKGFKRPLVQEDMWDLNKND----STHFICQTFEDVMAKE--LKKARNNLQKKKSKKRKTVDAEGQNGLAKGVSQDVLVMETETEKESKKKKKKKQKDSDSDYPQSWLVTTIVKSFKGVLLESALFKLLQDLLSFASPQLLKLMIA-FTQNKDSYAWTGYLYAVLLVLVAFVQSVVLQQYFQRCFILGMKVRTAIMAAVYKKALVVSNDSRKESTAGEIVNLMSADAQRFNDVTNFIHLLWSCPLQIALSIAFLWIELGPSVLSGLLVMVLMVPINGWLATKSRQFQMQNMKFKDSRMKIVNDLLNGIKILKYYAWETSFEAQVQEIREKELKVMRKFAYLSSVSTFIFSCAPALVSLATFAVFVSVSPDNILDAEKAFTSISLFNILRFPLAMLPQLISIMVQTSVSKKRLEKFLSGDDL----DTTTVTHNSSITAAVSMTNGTYAWERDTEPVLKQVSLDIKPGRLVAVVGAVGSGKTSLVSALLGELHSIKGNININGSVAYVPQQAWIQNATLKDNILFGSSVDEERYQSVIKACALEPDLDLLPGRDQTEIGEKGINLSGGQKQRVSLARAVYSSADVYLLDDPLSAVDSHVGKHLFEKVIGPNGLLRDKTRILVTHGISFLPYVDEIVVLV-HGVVSEIGSYESLRASKGAFSEFL-ETYGKDESNKDNDKKAAAAQTPVYEEIETLPEGLETQADGSPEDIVSSTLKRENSLRHSQRHSKRNGSVKVRKNSSLRAQKDPEDKKGQRLIEKEMMETGRVKFSVYLQYLSAMGWWYVGFSFVFYFIQNVAVIGQNLWLSDWTDDSIEYFNQTYPNHIRDT---RIGVFGALGLAQGFLVFFGTILLADGSISASRTLHTSLLTNILKVPMMFFDTTPSGRIVNRFAKDIFTVDEMIPMSFRSWILCLLGVLGTLFVICLATPIFTAVVVPMAVVYYFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQDRFLKHNEDTIDQNLKSVYPWIVSNRWLAMRLESLGNLVVFFAALFAVISRDSLNSGLVGLSISYALNVTQTLNWLVRMTSELETNIVAVERVREYAEIQNEAPWVTSVRPPDDWPSAGNIRFEDYKVRYRPELELVLHGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDLRSRLTIIPQDPVLFSGTLRMNLDPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLSLGQRQLLCLARALLRKSRILILDEATAAVDLETDDLIQSTIRREFSHCTVLTIAHRLNTILDSSRVMVLDSGKIVEFDSPNELLSK-PGHFSSMAE-DAGIRREEE 1560 HSP 2 Score: 60.4622 bits (145), Expect = 2.078e-8 Identity = 113/497 (22.74%), Postives = 216/497 (43.46%), Query Frame = 3
Query: 1209 TYSAGDIINMTMVDM---EQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKY--SEKELMWKDK--RMNILT---EILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEK-----VFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIG-NP----VLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTV-------------QTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNN 2600
T +G I+N D+ ++++ SWIL C ++ T+ ++ L IF V V+P+ + + + Y + ++L D R I + E ++G+ VI+ Y + F E + LK+ + + L + + + LV++ + F++IS + V ++I N+ + L ++ T +V+ R+ ++ EI ++ P V + P N RF ++ P VL + ++ + I +VGR G GKSSL + + + +G + ++ +PQ+ + + TLR N+ ++F+ VL+ L+ + LP + E+ E G NLS GQ+Q + LARA+ + S I +LD+ +AVD+ L I + H T + + H L + + V+ D G+I E + L+ F S ++ + ++ Q+
Sbjct: 1092 TTPSGRIVNRFAKDIFTVDEMIPMSFRSWIL--CLLGVLGTLFVIC--LATPIFTAV-----VVPMAVVYYFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQDRFLKHNEDTIDQNLKSVYPWIVSNRWLAMRLESLGNLVVF-------FAALFAVISRDSLNSGLVGLSISYALNVTQTLNWLVRMTSELETNIVAVERVREY---AEI--QNEAPWVTSVRPPDDWPSAGNIRFEDYKVRYRPELELVLHGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDLRSRLTIIPQDPVLFSGTLRMNLDPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLSLGQRQLLCLARALLRKSRILILDEATAAVDLET-DDLIQSTIRRE--FSHCTVLTIAHRLNTILDSSRVMVL-DSGKIVEFDSPNELLSKPGHFSSMAEDAGIRREEEQSQ 1563
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Source:ZFIN;Acc:ZDB-GENE-050517-15]) HSP 1 Score: 829.706 bits (2142), Expect = 0.000e+0 Identity = 501/1310 (38.24%), Postives = 768/1310 (58.63%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSE--DEEFLINSEEKESFILEHSGKVLIKSI---------------FGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLY-AFVFL---IQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYF--NDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGV--LQAFG-NVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES-INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFK 4463
PE AS S++T+ W+ + YK + +K + L++ +KS + Q + + +R + E+K+ +E S +L K++ FG +F L++ L +I+ D+L+ P +L+LL+ + + TW G Y A +F+ +Q LI + + CF +R+R +++G + RK L ++ A+ T + G+I+N+ VD ++ M+ I Y ++ S P Q+IL + L+ LG S+ GVA++V ++P+ I TK Y ++ KD R+ ++ E+LNGIKV+K+Y WE +F K+ +IR+ EL+ + + I + PFLV STF Y+ +I+ A+K F+++ LFN ++ P+ +LP ++ + A VS R+ FL S+E +V +P SI I +G FSW++ P LK I +++ + L+AVVG VG GKSSLLSA+LGEM+ G+V +G +AYVPQ+AWIQN TL++NIL + +Y KV++AC L D+E LP D TEIGE+GVNLSGGQKQRVS+ARAVY + +YLLDD LSAVD +VG+ +F K+I QGLL+ +TRVLVTHGL +LP D I V+ D G+I+E G+Y L+ F FL ++ + + + S S+G N++A K + ++ ++ +GRV L S+ W Y KA G+ + SI + +F L + G N WL + D + N ++ + + YG +G+ Q +AV + GG+ AS+ +H +L VLRS + FF TPSG ++NRF K+ ID + I + ++ S VI I TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V TH ET G+S+IR+ + F +D + K ++ RWL +RL+ +GN IV + +FAV+ R +LS ++GLSISYALQVT LNWL R +E ETN V++ER+++Y E+ N+ + W + G+I + F L+Y +L + +I++NI GGEK+G+VGRTGAGKSSL L LFR++E G I IDGVNI +GLH+LR ++TI+PQDPV+FSG+L+ NLDPFD YTD+++ +SLE++ + +V+ L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D +++ LD G + EF SP L++ +K
Sbjct: 217 PESGASFLSKITFWWITGLMVKGYKRPLEEKDLWSLNNEDKSE---RVVPQLVRRWDQECVKVKRPVDKTLYSPKRSTRGEKKDGQPVEESEILLAKALQKTGEPSLFFALCRTFGPYF---LVSSLYKIIHDVLMFVGPEILRLLILFVNDSSAP-TWHGYFYTALLFVCTCLQTLILQKYFHVCFV----TGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGASVLAGVAVMVLMVPLNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKGKVSAIRESELRVLKKMAYLGAISTFTWVCAPFLVALSTFAVYVLVDENNILDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMQRLRVFL-SHEELDDDNVERPAISGTPD-SIRIADGAFSWSKDDPPTLKRINVSIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGSVSIKGSVAYVPQQAWIQNATLKDNILFGRETKDSWYQKVVEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGLLQGRTRVLVTHGLSFLPQADLILVMVD-GEITEMGSYTELLGRQGAFAEFLRTYTN------------TEQEEGEESLGGEQTSEGLSSNDDAAATKTKSAEASRLTEADKANTGRVKL-SVFWEYMKAIGLPL---SIFSIFLFFCHHLSSLGSNYWLSLWTD------DPVVNNTQPKREMRLGVYGALGISQGIAVFCYSVSVSVGGILASRYLHQTMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQMKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIKESDGRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVMARNNLSPGIMGLSISYALQVTASLNWLVRMSSELETNIVAVERVKEYGDTEKEAEWKLENSNLPPGWPTAGHIEIHKFGLRYREDLELAICDISVNIAGGEKVGIVGRTGAGKSSLTLGLFRIIEAAEGEIRIDGVNIADLGLHELRSRITIIPQDPVLFSGSLRMNLDPFDGYTDEEVWRSLELAHLKTFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGQMAEFDSPSNLIAKKGIFYK 1490
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 2 [Source:ZFIN;Acc:ZDB-GENE-040426-1523]) HSP 1 Score: 827.009 bits (2135), Expect = 0.000e+0 Identity = 504/1372 (36.73%), Postives = 791/1372 (57.65%), Query Frame = 3
Query: 615 HPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRAS--------------KSEDEEFLINSEEKESFILE---------------------HSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSA---PNKRKRSRLSTSGSQGFDGN-ENAEENYEKYFNDISH----------------------------------EEEIM-SGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTF-NQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHEDK 4505
+PE A+ S++T+ W +S ++ +K + + +DL+ + ++ Q F + +E ++A +E + L ++ ++E + L+ +I + ++L + L ++++D+L P +LKL++ F + + +Y W G LYA + ++ + SV F + ++VR +++ + +K L +S +++ +AG+I+N+ D ++ + + +L SCP QI L++ L+ ELG S+ G+ ++V ++P+ + ++++ + + +KD RM I+ ++LNGIK++K Y WE SF +++ IR++ELK R ++ + +F P LV +TF ++ P +I+ AEK F +I LFN ++ P+ +LP ++ + VS R+ KFL +++ V S A++ + NG ++W R PVLK + L ++ +L+AVVG VG GK+SL+SA+LGE++++ G + G +AYVPQ+AWIQN TL++NIL S ++ Y V+ AC L D++ LP RDQTEIGE+G+NLSGGQKQRVSLARAVY +D+YLLDD LSAVD +VG+ LF K+I GLL+ KTR+LVTHG+ +LP+VDEI V+ G +SE G+YE L F FL E+ K + N++N + +A P + L DG+ E+ + K N + H E+E+M +GRV + + Y A G + G S + I V N+WL D N T+ N R++ I +G +GL Q V G + AS+ +H+ LL +L+ + FF+ TPSGRI+NRF KD+F +D + ++ I + ++ +L VI + TP F V +P+ + Y +Q FY+++SRQ RRLDS + S + +H ET SG S+IR+ + F ID++ K +S RWL +RL+ LGNL+VF + +FAV++R SL++ LVGLSISYAL VT LNWL R +E ETN V++ER+R+Y I E+ T+ ++W S GNI E++ ++Y L VL +T +I EKIG+VGRTGAGKSSL LFR+VE GRI ID ++I ++GLH LR +LTI+PQDPV+FSGTL+ NLDPF ++D ++ LE++ + ++V L G+ ++ G NLS+GQ+QL+CLAR LL+KS+I+ILDEATA+VD ETD + I+ +F TV+ IAHRL TI+D +++ LD G I+EF SP ELLS GHF ++A+ D I+ E++
Sbjct: 193 NPEAKATFLSRITFNWFNSMVWKGFKRPLVQEDMWDLNKND----STHFICQTFEDVMAKE--LKKARNNLQKKKSKKRKTVDAEGQNGLAKGVSQDVLVMETETEKESKKKKKKKQKDSDSDYPQSWLVTTIVKSFKGVLLESALFKLLQDLLSFASPQLLKLMIA-FTQNKDSYAWTGYLYAVLLVLVAFVQSVVLQQYFQRCFILGMKVRTAIMAAVYKKALVVSNDSRKESTAGEIVNLMSADAQRFNDVTNFIHLLWSCPLQIALSIAFLWIELGPSVLSGLLVMVLMVPINGWLATKSRQFQMQNMKFKDSRMKIVNDLLNGIKILKYYAWETSFEAQVQEIREKELKVMRKFAYLSSVSTFIFSCAPALVSLATFAVFVSVSPDNILDAEKAFTSISLFNILRFPLAMLPQLISIMVQTSVSKKRLEKFLSGDDL----DTTTVTHDSSITAAVSMTNGTYAWERDTEPVLKQVSLDIKPGRLVAVVGAVGSGKTSLVSALLGELHSIKGNININGSVAYVPQQAWIQNATLKDNILFGSSVDEERYQSVIKACALGPDLDLLPGRDQTEIGEKGINLSGGQKQRVSLARAVYSSADVYLLDDPLSAVDSHVGKHLFEKVIGPNGLLRDKTRILVTHGISFLPYVDEIVVLV-HGVVSEIGSYESLRASKGAFSEFL-ETYGKDESNKDNDKKAAAAQTPVYEEIETLPEGLETQADGSPEDIVSSTLKRENSLRHSQRHSKRNGSVKVRKNSSLRAQKDPEDKKGQRLIEKEMMETGRVKFSVYLQYLSAMGWWYVGFSFVFYFIQNVAVIGQNLWLSDWTDDSIEYFNQTYPNHIRDT---RIGVFGALGLAQGFLVFFGTILLADGSISASRTLHTSLLTNILKVPMMFFDTTPSGRIVNRFAKDIFTVDEMIPMSFRSWILCLLGVLGTLFVICLATPIFTAVVVPMAVVYYFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQDRFLKHNEHTIDQNLKSVYPWIVSNRWLAMRLESLGNLVVFFAALFAVISRDSLNSGLVGLSISYALNVTQTLNWLVRMTSELETNIVAVERVREYAEIQNEAPWVTSVRPPDDWPSAGNIRFEDYKVRYRPELELVLHGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDLRSRLTIIPQDPVLFSGTLRMNLDPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLSLGQRQLLCLARALLRKSRILILDEATAAVDLETDDLIQSTIRREFSHCTVLTIAHRLNTILDSSRVMVLDSGKIVEFDSPNELLSK-PGHFSSMAE-DAGIRREEE 1546 HSP 2 Score: 60.077 bits (144), Expect = 2.810e-8 Identity = 113/497 (22.74%), Postives = 216/497 (43.46%), Query Frame = 3
Query: 1209 TYSAGDIINMTMVDM---EQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKY--SEKELMWKDK--RMNILT---EILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEK-----VFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIG-NP----VLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTV-------------QTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNN 2600
T +G I+N D+ ++++ SWIL C ++ T+ ++ L IF V V+P+ + + + Y + ++L D R I + E ++G+ VI+ Y + F E + LK+ + + L + + + LV++ + F++IS + V ++I N+ + L ++ T +V+ R+ ++ EI ++ P V + P N RF ++ P VL + ++ + I +VGR G GKSSL + + + +G + ++ +PQ+ + + TLR N+ ++F+ VL+ L+ + LP + E+ E G NLS GQ+Q + LARA+ + S I +LD+ +AVD+ L I + H T + + H L + + V+ D G+I E + L+ F S ++ + ++ Q+
Sbjct: 1078 TTPSGRIVNRFAKDIFTVDEMIPMSFRSWIL--CLLGVLGTLFVIC--LATPIFTAV-----VVPMAVVYYFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQDRFLKHNEHTIDQNLKSVYPWIVSNRWLAMRLESLGNLVVF-------FAALFAVISRDSLNSGLVGLSISYALNVTQTLNWLVRMTSELETNIVAVERVREY---AEI--QNEAPWVTSVRPPDDWPSAGNIRFEDYKVRYRPELELVLHGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDLRSRLTIIPQDPVLFSGTLRMNLDPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLSLGQRQLLCLARALLRKSRILILDEATAAVDLET-DDLIQSTIRRE--FSHCTVLTIAHRLNTILDSSRVMVL-DSGKIVEFDSPNELLSKPGHFSSMAEDAGIRREEEQSQ 1549
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc6a (ATP-binding cassette, sub-family C (CFTR/MRP), member 6a [Source:ZFIN;Acc:ZDB-GENE-050517-18]) HSP 1 Score: 824.313 bits (2128), Expect = 0.000e+0 Identity = 517/1529 (33.81%), Postives = 843/1529 (55.13%), Query Frame = 3
Query: 42 DSFWSNSHLQSPNYPIFTNCFQYTLLIIGPSIFFITFSI-------------LLLERLFNKKHLKIITFHSFDLRHSXXXXXXXXXXXXVFAEMLIDNLYTTNKDSMLFISCGXXXXXXXXXXXXTELRR-RGNKSIDVILFVFWWM-VFCGYFFRYYSHFIALLQNSKPN--RXXXXXXXXXXXXXXXXXXXXDTFLRFPPNLRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKS-----SINSEISAQYFHNYGEREDIFRRA---SKSEDEEFLINSEEKESFILEHSGKVLIKSI---FGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENY----CFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIE---IQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLST----------SGSQGFDGNENA----------EENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESI-NETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHF 4460
D W + + P +NCFQ T+L+ P I+ S L L L N K L SF F +L++ ++ + +S + S ++ R RG +S V LF FW + V C + +A+ Q P+ R + F L + + + P AS S++ + W I+ Y+ + + + L + S + E +A+ + + A S+ D+ L+ +KE + SG L++++ FG +F L L IV D+ + ++P VL LLL + K+ + WKG YA + + + SVF + CFT + +RV+ +V+G++ RK+L +++ A+ T + G+I+N+ D +++M+++VY + P ++ L + L+ LG S G+A ++ + P+ I R K E ++ + D R+ ++ EILNGIK++K Y WEK+F ++ R++ELK + I + + F+ FL+ ++ F Y+ +++ A+K+F+++ L N ++ P+ LP+ ++ T+ A+VS R+GKFL +E+ P + V + S + ++ NG FSW++ G P LK I + V L+AVVG VG GKSSLLSA+LGE +GTV +G IAYVPQ+AWIQN +L++NIL + + +Y +VL+AC L D+++LP D TEIGE+G+NLSGGQKQRVSLARAVY+ D+YLLDD LSAVD +VGQ +FNK+I +G+L+ KTRVLVTHG+ +LP D I V+ D G+ISERG+Y+ L++ F F++ ++ + + + RK RLS S Q G+ N+ E++ + ++ ++ GRV L + YF+ G+ + S + N WL + AD Q ++N + N + YG +G Q +++ G + AS+ +H LL+ VL S + FF +TPSG +LNRF K++ ID+ + + +++ L +++ + TP+ ++ +P++ Y +Q FY+++S Q RRL+S + S + THL ET G+S+IR+ +S F +D + ++++ RWL + L+ LGN IV + I +V+ + +LS +VGL++S++LQVTG L+W+ R + E N VS+ER+++Y P E+ + + + +W G I +++ LQY L LK I+++I+ EKIG+VGRTGAGKSSLAL +FR++E G I+IDG+NI IGLH LR ++TI+PQDPV+FSG+L+ NLDPF+ Y+D+++ +LE++ + ++V+ L + +N++C G NLS+GQ+QL+CLAR LL+K+K+++LDEATA++D ETD + I+ QF V+ IAHRL TI+D K+I +D G ++E SP L++ G F
Sbjct: 11 DPLWDWNQTWYTHRPELSNCFQNTVLVWAPCIYLWVLSPFYCLHLYCHGRGRLPLSSLCNAKLLLGFFLASFGFVE--------------FFYILLERRLEIHQHLVFLLSPIMRSLTVVLAVCVIHWERVRGCRS-SVFLFFFWLLGVLCSIIPLHAKVQLAVEQGLSPDIVRYLAFFSYFALQLAQLFLSCFADQAPLGKAVHKNACPVQDASFLSKILFWWFSGLIFKGYRSPLQAEDLWSLREEDTSERIISDLEEEWTAKRTKLQQQENHMSTSAALGSRLPDQAQLLRKIQKE----QSSGFCLLRTLARSFGPYF---LTGTLCLIVHDVFMFSVPQVLSLLLGFMKD-EDTPLWKGYFYATLMFLLSCLQSVFNHQYTYTCFT----VGMRVKTAVMGLVYRKSLVMNSSARRTCTVGEIVNLVSADTQKLMDFVVYFNAVWLAPIEVTLCLFFLWQHLGPSALAGIATVIFIFPLNGFIARKRSKLQEIQMKYMDGRVKLMNEILNGIKILKFYAWEKAFLEQVLGYREKELKTLKKSQILYSVSLASFNSSSFLIAFAMFGVYVLIDDKNVLDAQKIFVSMALINILKTPLSQLPFAMSTTMQALVSLKRLGKFLCQDELKPDN-----VARESFKSDVDGVVFDNGTFSWSKDGPPCLKRISVKVPCGSLVAVVGHVGSGKSSLLSAMLGETEKRSGTVSVKGSIAYVPQQAWIQNASLQDNILFGREKKESWYQRVLEACALLPDLDNLPAGDATEIGEKGLNLSGGQKQRVSLARAVYRKGDVYLLDDPLSAVDAHVGQHIFNKVIGPKGILRDKTRVLVTHGMSFLPQADLILVLVD-GEISERGSYQELLNRNGAFADFIHTFANS--ERKECFSEALQRGSRKSVRLSVTDYMPFSRDLSQEQLIGGDTNSIAIEPLPDSDEDHIPEDLGKLTKVDKARIGRVKLEMYIEYFRTIGLPLIISIVFLYAFQQAASLSNNYWLSLWAD-QPVINGTQLN-----TDLKLGVYGALGFAQGISIFGTTVAISLGCIIASRHLHLDLLNNVLHSPMSFFESTPSGNLLNRFAKEIDAIDNMIPDGLKMMLSYFFKLTEVCIIVLMATPFAAVIILPMVFLYGFIQSFYVATSCQLRRLESVSRSPIYTHLNETVQGASVIRAFNEQSRFIMGANHKVDHNQTAYFPRFIATRWLGVNLEFLGNGIVLAASILSVMAKGTLSPGMVGLAVSHSLQVTGFLSWIVRSWTDVENNIVSVERVKEYADTPKEAAWSIEGSSLPPSWPQTGTIEFQDYGLQYRKGLELALKGISVHIHEREKIGIVGRTGAGKSSLALGIFRILEAAKGEIYIDGINIAEIGLHDLRSRITIIPQDPVLFSGSLRMNLDPFNAYSDEEVWNALELAHLKNFVSELPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKVLVLDEATAALDLETDTLIQSTIRSQFEDCAVLTIAHRLNTIMDYTKVIVMDKGHVVEMDSPSNLIAK-RGQF 1497
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 846.655 bits (2186), Expect = 0.000e+0 Identity = 508/1317 (38.57%), Postives = 777/1317 (59.00%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKS-SINSEISAQYFHNYGE---REDIFRRASKSEDEEFLINS-----EEKESFILEHSGKVLIKSIFGAHFHII----LIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFL----IQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRL-----------------STSGSQGFDGNENAEENY-EKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISE-NWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHF 4460
PE AS SQ+T+ W+ + +K + K + L+ +KS + +S + Y + ++ + + + +NS EE E+ I++ + K L S+ A + I+C + D+L+ + P +L+LL+ + +K W G LY F+ +Q LI + + CF +R++ +V+G++ RK L ++ A+ T + G+I+N+ VD ++ M+ Y ++ S P Q+IL LL+ LG S+ G+A++V ++PV I TKKY ++ KD R+ ++ EILNGIKV+K+Y WE +F K+ IR++ELK + + + + PFLV STF Y+ +++ AEK F+++ LFN ++ P+ +LP ++ + A VS R+ FL E+ P S + Q S SI +++ FSW+R P LK+I +++ + L+AVVG+VG GKSSLLSA+LGEM +G V +G + YV Q+AWIQN +L++N+L + N+ Y KV++AC L D+E LP D+TEIGE+GVNLSGGQKQRVSLARAVY ++DIYLLDD LSAVD +VG+ +F+K+I +G+LK+KTR+LVTHG+ +LP +D I V+ D G+I+E G+Y+ L+ F FL ++ + N Q P+ ++ SRL ++S ++ + N+ + N EK ++ ++ +GRV L Y KA G+F+ SI + V N WL + D + N ++ + ++ YG +G Q +AV + GG+ AS+ +H+ LL VLR + FF TPSG ++NRF+K++ ID+T+ I + +I + V+I TP ++ P+ + Y +Q FY+++SRQ +RL+S + S V +H ET GSS+IR+ + F I +D++ + +S RWL +RL+ +GN IV + +FAV++R +LS LVGLS+SYALQVT LNWL R +E ETN V++ER+++Y + E+ E W G I + L+Y +L LKNI + I GGEK+G+VGRTGAGKSSL L LFR+ E +G I IDG N+ IGLH LR ++TI+PQDPV+FSGTL+ NLDPFD+YTDD + SLE++ + +V +L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ +F TVI IAHRL TI+D K+I LD G ++EF SP LL F
Sbjct: 203 PESSASFLSQITFWWISRMMVQGFKRPLEAKDLWSLNKEDKSLEVVPVLSKNWEKEYNKAKAKKVPLKMVYSPKKQTKKLNSKEDVREEAEALIVKPAPKELEPSLLKALYKTFGPYFFISCFFKFFHDVLMFSGPQLLQLLIKFVGDKDAP-DWHGYLYTFLLFFCACLQTLILHKYFHICFV----TGMRLKTAVVGLVYRKALVINNSARRTSTIGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILAFYLLWQNLGPSVLAGIAVMVLLVPVNAVIAMKTKKYQVVQMKCKDNRIKLMNEILNGIKVLKLYAWELAFKEKVLGIRKDELKVLKKSAYLAAVGTFTWVCAPFLVALSTFAVYVLIDKQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELEPESIIR--EPQKSSEGSINMKDATFSWSRNDLPSLKDINISIPEGSLVAVVGQVGCGKSSLLSALLGEMEKQDGYVAMKGSVGYVSQQAWIQNASLKDNVLFGRESNESMYKKVIEACALLPDLEILPTGDRTEIGEKGVNLSGGQKQRVSLARAVYCNTDIYLLDDPLSAVDAHVGKHIFDKVIGPKGMLKNKTRILVTHGVSYLPQMDSIIVMVD-GKITEVGSYQDLLMQDGAFAEFLRTYANA----EQNKDQEGKPSNQEESRLYLNRFHIHFLFNFRQLSASSETKSLNQNKTGDLNSSEKDDWKLTEADKAKTGRVKLAVFWEYMKAIGLFLCFLSIFLFMCNHVASLASNYWLSLWTD------DKVVNGTQQNTTMRLSVYGALGFSQGIAVYGYSTAVSLGGILASRFLHTDLLHNVLRFPMSFFERTPSGNLVNRFSKEIDTIDNTIPQIIKMFMGSLFNVIGACVIILTATPIVAVIIPPLGLVYFFVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGSSVIRAFGEQKRFIQISDFKVDENQRAYYPSIVSNRWLAIRLEFVGNCIVLFASLFAVISRTTLSPGLVGLSVSYALQVTTYLNWLVRMSSELETNIVAVERVKEYADLKQEAAWTVQETAPEATWPHEGKIEFRGYGLRYREDLDLALKNINVTIQGGEKVGIVGRTGAGKSSLTLGLFRINEAAAGEIVIDGCNLAKIGLHDLRFRVTIIPQDPVLFSGTLRMNLDPFDKYTDDDIWTSLELAHLKRFVANLPDRLNHECAEGGENLSIGQRQLVCLARALLRKTKILVLDEATAAVDLETDGLIQSTIRKEFQDCTVITIAHRLNTIMDYTKVIVLDKGQVVEFDSPSNLLQQQGIFF 1501
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 846.269 bits (2185), Expect = 0.000e+0 Identity = 510/1315 (38.78%), Postives = 780/1315 (59.32%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKS-SINSEISAQYFHNYGE---REDIFRRASKSEDEEFLINS-----EEKESFILEHSGKVLIKSIFGAHFHII----LIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFL----IQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSA-PNKRKR-------------SRLSTSG-SQGFDGNENAEENY-EKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISE-NWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHF 4460
PE AS SQ+T+ W+ + +K + K + L+ +KS + +S + Y + ++ + + + +NS EE E+ I++ + K L S+ A + I+C + D+L+ + P +L+LL+ + +K W G LY F+ +Q LI + + CF +R++ +V+G++ RK L ++ A+ T + G+I+N+ VD ++ M+ Y ++ S P Q+IL LL+ LG S+ G+A++V ++PV I TKKY ++ KD R+ ++ EILNGIKV+K+Y WE +F K+ IR++ELK + + + + PFLV STF Y+ +++ AEK F+++ LFN ++ P+ +LP ++ + A VS R+ FL E+ P S + Q S SI +++ FSW+R P LK+I +++ + L+AVVG+VG GKSSLLSA+LGEM +G V +G + YV Q+AWIQN +L++N+L + N+ Y KV++AC L D+E LP D+TEIGE+GVNLSGGQKQRVSLARAVY ++DIYLLDD LSAVD +VG+ +F+K+I +G+LK+KTR+LVTHG+ +LP +D I V+ D G+I+E G+Y+ L+ F FL ++ ++N++ PS P++ KR +LS S ++ + N+ + N EK ++ ++ +GRV L Y KA G+F+ SI + V N WL + D + N ++ + ++ YG +G Q +AV + GG+ AS+ +H+ LL VLR + FF TPSG ++NRF+K++ ID+T+ I + +I + V+I TP ++ P+ + Y +Q FY+++SRQ +RL+S + S V +H ET GSS+IR+ + F I +D++ + +S RWL +RL+ +GN IV + +FAV++R +LS LVGLS+SYALQVT LNWL R +E ETN V++ER+++Y + E+ E W G I + L+Y +L LKNI + I GGEK+G+VGRTGAGKSSL L LFR+ E +G I IDG N+ IGLH LR ++TI+PQDPV+FSGTL+ NLDPFD+YTDD + SLE++ + +V +L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ +F TVI IAHRL TI+D K+I LD G ++EF SP LL F
Sbjct: 193 PESSASFLSQITFWWISRMMVQGFKRPLEAKDLWSLNKEDKSLEVVPVLSKNWEKEYNKAKAKKVPLKMVYSPKKQTKKLNSKEDVREEAEALIVKPAPKELEPSLLKALYKTFGPYFFISCFFKFFHDVLMFSGPQLLQLLIKFVGDKDAP-DWHGYLYTFLLFFCACLQTLILHKYFHICFV----TGMRLKTAVVGLVYRKALVINNSARRTSTIGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILAFYLLWQNLGPSVLAGIAVMVLLVPVNAVIAMKTKKYQVVQMKCKDNRIKLMNEILNGIKVLKLYAWELAFKEKVLGIRKDELKVLKKSAYLAAVGTFTWVCAPFLVALSTFAVYVLIDKQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELEPESIIR--EPQKSSEGSINMKDATFSWSRNDLPSLKDINISIPEGSLVAVVGQVGCGKSSLLSALLGEMEKQDGYVAMKGSVGYVSQQAWIQNASLKDNVLFGRESNESMYKKVIEACALLPDLEILPTGDRTEIGEKGVNLSGGQKQRVSLARAVYCNTDIYLLDDPLSAVDAHVGKHIFDKVIGPKGMLKNKTRILVTHGVSYLPQMDSIIVMVD-GKITEVGSYQDLLMQDGAFAEFLRTYAN-AEQNKDQEEAPSPVPSEEKRLENGILRNERNLQRQLSASSETKSLNQNKTGDLNSSEKDDWKLTEADKAKTGRVKLAVFWEYMKAIGLFLCFLSIFLFMCNHVASLASNYWLSLWTD------DKVVNGTQQNTTMRLSVYGALGFSQGIAVYGYSTAVSLGGILASRFLHTDLLHNVLRFPMSFFERTPSGNLVNRFSKEIDTIDNTIPQIIKMFMGSLFNVIGACVIILTATPIVAVIIPPLGLVYFFVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGSSVIRAFGEQKRFIQISDFKVDENQRAYYPSIVSNRWLAIRLEFVGNCIVLFASLFAVISRTTLSPGLVGLSVSYALQVTTYLNWLVRMSSELETNIVAVERVKEYADLKQEAAWTVQETAPEATWPHEGKIEFRGYGLRYREDLDLALKNINVTIQGGEKVGIVGRTGAGKSSLTLGLFRINEAAAGEIVIDGCNLAKIGLHDLRFRVTIIPQDPVLFSGTLRMNLDPFDKYTDDDIWTSLELAHLKRFVANLPDRLNHECAEGGENLSIGQRQLVCLARALLRKTKILVLDEATAAVDLETDGLIQSTIRKEFQDCTVITIAHRLNTIMDYTKVIVLDKGQVVEFDSPSNLLQQQGIFF 1492
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 844.729 bits (2181), Expect = 0.000e+0 Identity = 508/1315 (38.63%), Postives = 779/1315 (59.24%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKS-SINSEISAQYFHNYGE---REDIFRRASKSEDEEFLINS-----EEKESFILEHSGKVLIKSIFGAHFHII----LIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFL----IQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSA-PNKRKR-------------SRLSTSG-SQGFDGNENAEENY-EKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISE-NWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHF 4460
PE AS SQ+T+ W+ + +K + K + L+ +KS + +S + Y + ++ + + + +NS EE E+ I++ + K L S+ A + I+C + D+L+ + P +L+LL+ + +K W G LY F+ +Q LI + + CF +R++ +V+G++ RK L ++ A+ T + G+I+N+ VD ++ M+ Y ++ S P Q+IL LL+ LG S+ G+A++V ++PV I TKKY ++ KD R+ ++ EILNGIKV+K+Y WE +F K+ IR++ELK + + + + PFLV STF Y+ +++ AEK F+++ LFN ++ P+ +LP ++ + A VS R+ FL E+ P S ++ SI +++ FSW+R P LK+I +++ + L+AVVG+VG GKSSLLSA+LGEM +G V +G + YV Q+AWIQN +L++N+L + N+ Y KV++AC L D+E LP D+TEIGE+GVNLSGGQKQRVSLARAVY ++DIYLLDD LSAVD +VG+ +F+K+I +G+LK+KTR+LVTHG+ +LP +D I V+ D G+I+E G+Y+ L+ F FL ++ ++N++ PS P++ KR +LS S ++ + N+ + N EK ++ ++ +GRV L Y KA G+F+ SI + V N WL + D + N ++ + ++ YG +G Q +AV + GG+ AS+ +H+ LL VLR + FF TPSG ++NRF+K++ ID+T+ I + +I + V+I TP ++ P+ + Y +Q FY+++SRQ +RL+S + S V +H ET GSS+IR+ + F I +D++ + +S RWL +RL+ +GN IV + +FAV++R +LS LVGLS+SYALQVT LNWL R +E ETN V++ER+++Y + E+ E W G I + L+Y +L LKNI + I GGEK+G+VGRTGAGKSSL L LFR+ E +G I IDG N+ IGLH LR ++TI+PQDPV+FSGTL+ NLDPFD+YTDD + SLE++ + +V +L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ +F TVI IAHRL TI+D K+I LD G ++EF SP LL F
Sbjct: 168 PESSASFLSQITFWWISRMMVQGFKRPLEAKDLWSLNKEDKSLEVVPVLSKNWEKEYNKAKAKKVPLKMVYSPKKQTKKLNSKEDVREEAEALIVKPAPKELEPSLLKALYKTFGPYFFISCFFKFFHDVLMFSGPQLLQLLIKFVGDKDAP-DWHGYLYTFLLFFCACLQTLILHKYFHICFV----TGMRLKTAVVGLVYRKALVINNSARRTSTIGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILAFYLLWQNLGPSVLAGIAVMVLLVPVNAVIAMKTKKYQVVQMKCKDNRIKLMNEILNGIKVLKLYAWELAFKEKVLGIRKDELKVLKKSAYLAAVGTFTWVCAPFLVALSTFAVYVLIDKQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELEPES---IIREPQKTEGSINMKDATFSWSRNDLPSLKDINISIPEGSLVAVVGQVGCGKSSLLSALLGEMEKQDGYVAMKGSVGYVSQQAWIQNASLKDNVLFGRESNESMYKKVIEACALLPDLEILPTGDRTEIGEKGVNLSGGQKQRVSLARAVYCNTDIYLLDDPLSAVDAHVGKHIFDKVIGPKGMLKNKTRILVTHGVSYLPQMDSIIVMVD-GKITEVGSYQDLLMQDGAFAEFLRTYAN-AEQNKDQEEAPSPVPSEEKRLENGILRNERNLQRQLSASSETKSLNQNKTGDLNSSEKDDWKLTEADKAKTGRVKLAVFWEYMKAIGLFLCFLSIFLFMCNHVASLASNYWLSLWTD------DKVVNGTQQNTTMRLSVYGALGFSQGIAVYGYSTAVSLGGILASRFLHTDLLHNVLRFPMSFFERTPSGNLVNRFSKEIDTIDNTIPQIIKMFMGSLFNVIGACVIILTATPIVAVIIPPLGLVYFFVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGSSVIRAFGEQKRFIQISDFKVDENQRAYYPSIVSNRWLAIRLEFVGNCIVLFASLFAVISRTTLSPGLVGLSVSYALQVTTYLNWLVRMSSELETNIVAVERVKEYADLKQEAAWTVQETAPEATWPHEGKIEFRGYGLRYREDLDLALKNINVTIQGGEKVGIVGRTGAGKSSLTLGLFRINEAAAGEIVIDGCNLAKIGLHDLRFRVTIIPQDPVLFSGTLRMNLDPFDKYTDDDIWTSLELAHLKRFVANLPDRLNHECAEGGENLSIGQRQLVCLARALLRKTKILVLDEATAAVDLETDGLIQSTIRKEFQDCTVITIAHRLNTIMDYTKVIVLDKGQVVEFDSPSNLLQQQGIFF 1466
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 843.573 bits (2178), Expect = 0.000e+0 Identity = 509/1325 (38.42%), Postives = 776/1325 (58.57%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKS-SINSEISAQYFHNYGE---REDIFRRASKSEDEEFLINS-----EEKESFILEHSGKVLIKSIFGAHFHII----LIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFL----IQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL------NESSDKVDKNQNN-------------------LIQPSAPNKRKRSRLSTSGSQGFDGNENAEENY-EKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISE-NWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHF 4460
PE AS SQ+T+ W+ + +K + K + L+ +KS + +S + Y + ++ + + + +NS EE E+ I++ + K L S+ A + I+C + D+L+ + P +L+LL+ + +K W G LY F+ +Q LI + + CF +R++ +V+G++ RK L ++ A+ T + G+I+N+ VD ++ M+ Y ++ S P Q+IL LL+ LG S+ G+A++V ++PV I TKKY ++ KD R+ ++ EILNGIKV+K+Y WE +F K+ IR++ELK + + + + PFLV STF Y+ +++ AEK F+++ LFN ++ P+ +LP ++ + A VS R+ FL E+ P S + Q S SI +++ FSW+R P LK+I +++ + L+AVVG+VG GKSSLLSA+LGEM +G V +G + YV Q+AWIQN +L++N+L + N+ Y KV++AC L D+E LP D+TEIGE+GVNLSGGQKQRVSLARAVY ++DIYLLDD LSAVD +VG+ +F+K+I +G+LK+KTR+LVTHG+ +LP +D I V+ D G+I+E G+Y+ L+ F FL ++ D+ K N + P A N R ++S ++ + N+ + N EK ++ ++ +GRV L Y KA G+F+ SI + V N WL + D + N ++ + ++ YG +G Q +AV + GG+ AS+ +H+ LL VLR + FF TPSG ++NRF+K++ ID+T+ I + +I + V+I TP ++ P+ + Y +Q FY+++SRQ +RL+S + S V +H ET GSS+IR+ + F I +D++ + +S RWL +RL+ +GN IV + +FAV++R +LS LVGLS+SYALQVT LNWL R +E ETN V++ER+++Y + E+ E W G I + L+Y +L LKNI + I GGEK+G+VGRTGAGKSSL L LFR+ E +G I IDG N+ IGLH LR ++TI+PQDPV+FSGTL+ NLDPFD+YTDD + SLE++ + +V +L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ +F TVI IAHRL TI+D K+I LD G ++EF SP LL F
Sbjct: 181 PESSASFLSQITFWWISRMMVQGFKRPLEAKDLWSLNKEDKSLEVVPVLSKNWEKEYNKAKAKKVPLKMVYSPKKQTKKLNSKEDVREEAEALIVKPAPKELEPSLLKALYKTFGPYFFISCFFKFFHDVLMFSGPQLLQLLIKFVGDKDAP-DWHGYLYTFLLFFCACLQTLILHKYFHICFV----TGMRLKTAVVGLVYRKALVINNSARRTSTIGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILAFYLLWQNLGPSVLAGIAVMVLLVPVNAVIAMKTKKYQVVQMKCKDNRIKLMNEILNGIKVLKLYAWELAFKEKVLGIRKDELKVLKKSAYLAAVGTFTWVCAPFLVALSTFAVYVLIDKQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELEPESIIR--EPQKSSEGSINMKDATFSWSRNDLPSLKDINISIPEGSLVAVVGQVGCGKSSLLSALLGEMEKQDGYVAMKGSVGYVSQQAWIQNASLKDNVLFGRESNESMYKKVIEACALLPDLEILPTGDRTEIGEKGVNLSGGQKQRVSLARAVYCNTDIYLLDDPLSAVDAHVGKHIFDKVIGPKGMLKNKTRILVTHGVSYLPQMDSIIVMVD-GKITEVGSYQDLLMQDGAFAEFLRTYANAEQNKDQEGKPSNQEESRLYLNALYLLCVTVYYVYFPQAYNTGPRQLSASSETKSLNQNKTGDLNSSEKDDWKLTEADKAKTGRVKLAVFWEYMKAIGLFLCFLSIFLFMCNHVASLASNYWLSLWTD------DKVVNGTQQNTTMRLSVYGALGFSQGIAVYGYSTAVSLGGILASRFLHTDLLHNVLRFPMSFFERTPSGNLVNRFSKEIDTIDNTIPQIIKMFMGSLFNVIGACVIILTATPIVAVIIPPLGLVYFFVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGSSVIRAFGEQKRFIQISDFKVDENQRAYYPSIVSNRWLAIRLEFVGNCIVLFASLFAVISRTTLSPGLVGLSVSYALQVTTYLNWLVRMSSELETNIVAVERVKEYADLKQEAAWTVQETAPEATWPHEGKIEFRGYGLRYREDLDLALKNINVTIQGGEKVGIVGRTGAGKSSLTLGLFRINEAAAGEIVIDGCNLAKIGLHDLRFRVTIIPQDPVLFSGTLRMNLDPFDKYTDDDIWTSLELAHLKRFVANLPDRLNHECAEGGENLSIGQRQLVCLARALLRKTKILVLDEATAAVDLETDGLIQSTIRKEFQDCTVITIAHRLNTIMDYTKVIVLDKGQVVEFDSPSNLLQQQGIFF 1491
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: septin9 (septin 9 [Source:Xenbase;Acc:XB-GENE-1012202]) HSP 1 Score: 843.188 bits (2177), Expect = 0.000e+0 Identity = 504/1347 (37.42%), Postives = 771/1347 (57.24%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSI---------NSEIS--AQYFHNYGEREDIF--RRASKSEDEEFLI--NSEEKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFL---IQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDIS-------------------------------------HEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFG---NVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
PE A S+LT+ W YK + DK + L+ + S++ E S AQ +Y ++ + K+ + + LI N + KE L KVL+++ FG +F LI ++ +D+L P +L +L+ + K K W + +FL +Q LI YCF +R+R ++ G+I RK+L ++ AK + + G+++N+ VD ++ + + +L S P QI L + L+ LG S+ GVA++V +IP+ I T+ + +++ +KD R+ ++ EILNGIKV+K+Y WE SF K+ IR +EL + + + + PFLV +TF Y+ +I+ AEK F+++ LFN ++ P+ +LP ++ A VS RI FL ++E+ + + + PG +I + NG FSW + G +L+NI L V L+AVVG+VG GKSSL+SA+LGEM G V G +AYVPQ+AWIQN TL++NIL ++ N+ Y KVL+AC L D+E LP DQTEIGE+G+NLSGGQKQRVSLARAV+ ++D+YLLDD LSAVD +V + +F+ +I GLL+ KTRVLVTHG+ +LP VD I V+ D G+++E G+Y+ L+ F FL + + + ++ P ++ + D A E +K+ IS E +GRV + Y KA G+ + S+ C ++ A NVWL N NQ++ + + + Y +G+ Q L V+ G+ A++K+HS LLD + + F++ TP GRI+NRF+KD+++ID + I + +++++VI TP F +V IP+ I YI +Q FY+++SRQ +RL+S + S + +H ET +G+SIIR+ ++ F + +D++ K +S RWL +R++ +GN +V + +FAVL R LS LVGLS+SYALQVT LNW+ R ++ ETN V++ER+++Y E+ I +T E+W S G + L N+S++Y L VLKN+ + +NGGEK+G+VGRTGAGKSS+ L LFR++E G + ID VNI+ IGL LR +LTI+PQDPV+FSGTL+ NLDPF++Y+DD++ K+LE+S + +V + Y+C G NLS+GQ+QL+CLAR LL+K++I+ILDEATA++D ETD + I+ QF TV+ IAHRL TI+D +++ LD G I EF +P L++ G F +A+
Sbjct: 208 PESDAGFLSRLTFWWFTKMAILGYKRPLEDKDLWSLNEDDTSNVVVTNLIKEWEKEKSNLAQMQVSYSKKPEAVLNHTDEKAYESDVLIVDNKKPKEPSFL----KVLLRT-FGPYF---LIGSFFKLFQDLLSFVNPQLLSILITFIKNKDAPSWWGFCIAVLMFLTSLVQTLILHQHFQYCFV----TGMRLRSAITGIIYRKSLVITNSAKRSSTVGEVVNLMSVDAQRFQDLTTFLNMLWSAPLQICLALYFLWQALGPSVLAGVAVMVLLIPINAFIAMKTRAFQVEQMQYKDSRIKLMNEILNGIKVLKLYAWEPSFAQKVLEIRNKELNILKKAAYLNALSTFAWTSAPFLVALTTFAVYVTVDEKNILDAEKAFVSLSLFNILRFPLNMLPQVISNLAQASVSIKRIQNFLANDELDLNA---VTKDKTLPGNAITVHNGTFSWAKNGGAILQNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEVSVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINLSGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLPQVDHIVVLVD-GRVTEMGSYQELLKQNGAFSEFLRNYAFDDEVEEEDITIPDEEEVLLAEETLSTHTDLADNEPVANEARKKFIRQISILSDGEPSHAMSTRRRFTEKKPSENLVAKQPPTEKLIQTETTETGRVKMTVFWQYMKAVGLAI---SVFICFLYSCQNAAAIGANVWLS------DWTNEPVINQTQQNTQMRVGVYAALGILQGLLVMTSSFSLAIAGIGAARKLHSALLDNKMHTPQSFYDTTPIGRIINRFSKDIYVIDEVIPGTILMFLATFFTSLSTMIVIVASTPLFAVVIIPLAIAYIFVQRFYVATSRQLKRLESVSRSPIYSHFSETITGASIIRAYGRQNSFIVLSDNKVDENQKSYYPGIVSNRWLGVRVEFVGNCVVLFAALFAVLGREHLSPGLVGLSVSYALQVTMSLNWMVRMTSDLETNIVAVERVKEYAENETEAPWHIEDTKP--PEDWPSKGEVELSNYSVRYRAGLDLVLKNLNLKVNGGEKVGIVGRTGAGKSSMTLCLFRILEPAEGIVKIDNVNISEIGLQDLRSRLTIIPQDPVLFSGTLRMNLDPFNKYSDDEIWKALELSNLKKFVAGQPSQLEYECSEGGENLSVGQRQLVCLARALLRKTRILILDEATAAIDLETDDLIQMTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGRIAEFDTPTNLIA-LKGIFYGMAK 1526 HSP 2 Score: 94.3597 bits (233), Expect = 1.579e-18 Identity = 79/300 (26.33%), Postives = 138/300 (46.00%), Query Frame = 3
Query: 3627 LNWLTRQCAEFETNAVSIERIRQYTMIPVESINETN-NYISENWVSNGN-INLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQA---DEYIKHED 4502
LN L + + +VSI+RI+ + + +E + N ++++ GN I + N + + N +L+NI + + G + VVG+ G GKSSL AL +E G + + G + +PQ I + TLK N+ + K LE ++ + L G + G G NLS GQKQ + LAR + + + +LD+ ++VD + + + + T +++ H + + D I+ L DG + E GS +ELL +G F + D+ ++ ED
Sbjct: 590 LNMLPQVISNLAQASVSIKRIQNFL-----ANDELDLNAVTKDKTLPGNAITVHNGTFSWAKNGGAILQNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEVSVRG-------------SVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINLSGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLPQVDHIVVLVDGRVTEMGSYQELLKQ-NGAFSEFLRNYAFDDEVEEED 870
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Source:MGI Symbol;Acc:MGI:102676]) HSP 1 Score: 850.121 bits (2195), Expect = 0.000e+0 Identity = 508/1347 (37.71%), Postives = 788/1347 (58.50%), Query Frame = 3
Query: 594 PNLRETKH-----PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRR------------ASKSEDEEFLINSEEKESFILEHSGK--------VLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL----NESSDKVDKN-------------QNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHE-------EEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
P ET H PE AS S++T+ W+ + + Y+ + S DL S K + E+ +N+ + D R+ SK + L +EE E+ I++ K VL K+ FG +F L++ L + + D+++ P +L+L++N+ +++ W+G Y + + + ++ + F + +R++ +V+G + RK L ++ A+ + + G+I+N+ VD ++ M+ Y ++ S P Q+IL + L+ LG S+ GVA+++ ++P+ + TK Y + KD R+ ++ EILNGIKV+K+Y WE +F +K+ SIRQEELK + + + + PFLV STF ++ +I+ A+K F+++ LFN ++ P+ +LP ++ + A VS R+ FL E+ P S+ + G SI ++N F+W R P L I ++ + L+AVVG+VG GKSSLLSA+L EM + G V +G +AYVPQ+AWIQN++LR NIL + +Y V++AC L D+E LP+ D+TEIGE+GVNLSGGQKQRVSLARAVY +SDIYL DD LSAVD +VG+ +F K++ GLLK+KTR+LVTHG+ +LP VD I V++ G+ISE G+Y+ L+D F FL N D ++ +N ++ K + LS S S D ++ E E ++ +G+V L S+ W Y KA G+F+ SI + V N WL + D ++N + N++ F ++ YG +G+ Q A+ + GG+ AS+++H LL VLRS + FF TPSG ++NRF+K+L +D + I + +I ++++I + TP ++ P+ + Y +Q FY++SSRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV++R SLSA LVGLS+SY+LQ+T LNWL R +E ETN V++ER+++Y+ E+ I ET W +G + ++ L+Y +L VLK+I + I GGEK+G+VGRTGAGKSSL L LFR+ E G I IDGVNI IGLH LR ++TI+PQDPV+FSG+L+ NLDPF +Y+D+++ +LE++ + +V++L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D ++I LD G + E G+P ELL G F ++A+
Sbjct: 196 PLFSETVHDRNPCPESSASFLSRITFWWITGMMVHGYRQPLE---SSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPVRIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKT-FGPYF---LMSFLYKALHDLMMFAGPKILELIINFVNDREAP-DWQGYFYTALLFVSACLQTLALHQYFHICFVSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEP-DSIERRSIKSGEGNSITVKNATFTWARGEPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSG-GKISEMGSYQELLDRDGAFAEFLRTYANAEQDLASEDDSVSGSGKESKPVENGMLVTDTVGKHLQRHLSNSSSHSGDTSQQHSSIAELQKAGAKEETWKLMEADKAQTGQVQL-SVYWNYMKAIGLFITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQANRN-----FRLSVYGALGILQGAAIFGYSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAP--PSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELL-QQRGIFYSMAK 1523
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc3 (ATP-binding cassette, sub-family C (CFTR/MRP), member 3 [Source:MGI Symbol;Acc:MGI:1923658]) HSP 1 Score: 828.55 bits (2139), Expect = 0.000e+0 Identity = 487/1345 (36.21%), Postives = 784/1345 (58.29%), Query Frame = 3
Query: 591 PPNLRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKV----LIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFL---IQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQ-----------------------PSAPNKRKR--SRLSTSGSQGFDGNENAEENY------------EKYFNDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAF---GNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES--INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
P NL PE A FS+L++ W Y+ + D+ DL S + + ++ + + ++++ +AS+S+ +++ +L+ K ++++ +L++ +++++L P +L +L+ + + W +L +FL +Q LI + + F + ++R+R ++IG+I RK L ++ K + G+++N+ VD ++ M+ + +L S P Q+IL + L+ LG S GVA+IV +IP+ A+ K Y K++ +KD R+ +++EILNGIKV+K+Y WE SF +++ IRQ EL+ R + I ++ PFLV T Y+Y +++ AEK F+++ LFN +++P+ +LP ++ A VS RI FL NE+ P+ + +SPG +I I NG F+W + P L ++ + + K L+AVVG VG GKSSL+SA+LGEM L G V +G +AYVPQ+AWIQN TL+ N+L + N Y + L+ C L D++ LP DQTEIGE+G+NLSGGQ+QRVSLARAVY D++I+LLDD LSAVD +V + +F+++I +G+L KTRVLVTHG+ +LP D I V+ GQ+SE G Y L+ F +FL + D+ + +Q P+ RK+ +S+ S+G N + + K + EE +G V L S+ W Y K+ G+ +++ C+++G A NVWL + N++ + +N + Y +G+ Q L V+L + G ++A++ +H LL +RS FF+ TPSGRILNRF+KD+++ID L I ++N I++++VI TP F +V +P+ + Y +Q FY+++SRQ +RL+S + S + +H ET +G+S+IR+ DF+ + +D + K S RWL + ++ +GN +V + +FAV+ R SL+ LVGLS+SYALQVT LNW+ R ++ E+N +++ER+++Y+ E+ + E+N E W + G + N+S++Y L VLKN+T+++ GGEK+G+VGRTGAGKSS+ L LFR++E G I IDG+N+ IGLH LR QLTI+PQDP++FSGTL+ NLDPF Y+++ + ++LE+S + +V+S G+++ C G NLS+GQ+QL+CLAR LL+KS++++LDEATA++D ETD + I+ QF TV+ IAHRL TI+D ++++ LD G + EF SP L++ + G F +A+
Sbjct: 199 PENLDTNPCPEASAGFFSRLSFWWFTRLAILGYRRPLEDR---DLWSLSEEDCSHKVVQRLLEAWQKQQN---QASRSQTATAEPKIPGEDAVLLKPRPKSKQPSFLRALVRTFTSSLLMSACFNLIQNLLGFVNPQLLSILIRFISDPTAPTWWGFLLAGLMFLSSTMQTLILHQYYHCIFVM----ALRLRTAIIGVIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVIVLLIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQVKGIRQSELQLLRKGAYLQAISTFIWICTPFLVTLITLGVYVYVDESNVLDAEKAFVSLSLFNILKIPLNMLPQLISGLTQASVSLKRIQDFLNQNELDPQC---VERKTISPGYAITIHNGTFTWAQDLPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLAG-GQVSEMGHYSALLQHDGSFANFLRNYAPDEDQEDHEALQNANEEVLLLEDTLSTHTDLTDNEPAIYEVRKQFMREMSSLSSEGEVQNRTMPKKHTNSLEKEALVTKTKETGALIKEEIAETGNVKL-SVYWDYAKSMGLC---TTLSICLLYGGQSAAAIGANVWLSAWS------NDAEEHGQQNKTSVRLGVYAALGILQGLLVMLSAFTMVVGAIQAARLLHEALLHNKIRSPQSFFDTTPSGRILNRFSKDIYVIDEVLAPTILMLLNSFFTSISTIMVIVASTPLFMVVVLPLAVLYGFVQRFYVATSRQLKRLESISRSPIFSHFSETVTGTSVIRAYGRIQDFKVLSDTKVDNNQKSSYPYIASNRWLGVHVEFVGNCVVLFAALFAVIGRNSLNPGLVGLSVSYALQVTMALNWMIRMISDLESNIIAVERVKEYSKTKTEAPWVVESNR-APEGWPTRGMVEFRNYSVRYRPGLELVLKNVTVHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSEEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIA-AGGIFYGMAK 1517
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc3 (ATP-binding cassette, sub-family C (CFTR/MRP), member 3 [Source:MGI Symbol;Acc:MGI:1923658]) HSP 1 Score: 826.624 bits (2134), Expect = 0.000e+0 Identity = 488/1346 (36.26%), Postives = 786/1346 (58.40%), Query Frame = 3
Query: 591 PPNLRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKV----LIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFL---IQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL-NESSDKVDKNQNNLIQ-----------------------PSAPNKRKR--SRLSTSGSQGFDGNENAEENY------------EKYFNDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAF---GNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES--INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
P NL PE A FS+L++ W Y+ + D+ DL S + + ++ + + ++++ +AS+S+ +++ +L+ K ++++ +L++ +++++L P +L +L+ + + W +L +FL +Q LI + + F + ++R+R ++IG+I RK L ++ K + G+++N+ VD ++ M+ + +L S P Q+IL + L+ LG S GVA+IV +IP+ A+ K Y K++ +KD R+ +++EILNGIKV+K+Y WE SF +++ IRQ EL+ R + I ++ PFLV T Y+Y +++ AEK F+++ LFN +++P+ +LP ++ A VS RI FL NE+ P+ + +SPG +I I NG F+W + P L ++ + + K L+AVVG VG GKSSL+SA+LGEM L G V +G +AYVPQ+AWIQN TL+ N+L + N Y + L+ C L D++ LP DQTEIGE+G+NLSGGQ+QRVSLARAVY D++I+LLDD LSAVD +V + +F+++I +G+L KTRVLVTHG+ +LP D I V+ GQ+SE G Y L+ F +FL N + D+ ++ +Q P+ RK+ +S+ S+G N + + K + EE +G V L S+ W Y K+ G+ +++ C+++G A NVWL + N++ + +N + Y +G+ Q L V+L + G ++A++ +H LL +RS FF+ TPSGRILNRF+KD+++ID L I ++N I++++VI TP F +V +P+ + Y +Q FY+++SRQ +RL+S + S + +H ET +G+S+IR+ DF+ + +D + K S RWL + ++ +GN +V + +FAV+ R SL+ LVGLS+SYALQVT LNW+ R ++ E+N +++ER+++Y+ E+ + E+N E W + G + N+S++Y L VLKN+T+++ GGEK+G+VGRTGAGKSS+ L LFR++E G I IDG+N+ IGLH LR QLTI+PQDP++FSGTL+ NLDPF Y+++ + ++LE+S + +V+S G+++ C G NLS+GQ+QL+CLAR LL+KS++++LDEATA++D ETD + I+ QF TV+ IAHRL TI+D ++++ LD G + EF SP L++ + G F +A+
Sbjct: 199 PENLDTNPCPEASAGFFSRLSFWWFTRLAILGYRRPLEDR---DLWSLSEEDCSHKVVQRLLEAWQKQQN---QASRSQTATAEPKIPGEDAVLLKPRPKSKQPSFLRALVRTFTSSLLMSACFNLIQNLLGFVNPQLLSILIRFISDPTAPTWWGFLLAGLMFLSSTMQTLILHQYYHCIFVM----ALRLRTAIIGVIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVIVLLIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQVKGIRQSELQLLRKGAYLQAISTFIWICTPFLVTLITLGVYVYVDESNVLDAEKAFVSLSLFNILKIPLNMLPQLISGLTQASVSLKRIQDFLNQNELDPQC---VERKTISPGYAITIHNGTFTWAQDLPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLAG-GQVSEMGHYSALLQHDGSFANFLRNYAPDEDQEDHEAALQNANEEVLLLEDTLSTHTDLTDNEPAIYEVRKQFMREMSSLSSEGEVQNRTMPKKHTNSLEKEALVTKTKETGALIKEEIAETGNVKL-SVYWDYAKSMGLC---TTLSICLLYGGQSAAAIGANVWLSAWS------NDAEEHGQQNKTSVRLGVYAALGILQGLLVMLSAFTMVVGAIQAARLLHEALLHNKIRSPQSFFDTTPSGRILNRFSKDIYVIDEVLAPTILMLLNSFFTSISTIMVIVASTPLFMVVVLPLAVLYGFVQRFYVATSRQLKRLESISRSPIFSHFSETVTGTSVIRAYGRIQDFKVLSDTKVDNNQKSSYPYIASNRWLGVHVEFVGNCVVLFAALFAVIGRNSLNPGLVGLSVSYALQVTMALNWMIRMISDLESNIIAVERVKEYSKTKTEAPWVVESNR-APEGWPTRGMVEFRNYSVRYRPGLELVLKNVTVHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSEEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIA-AGGIFYGMAK 1518
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 2 [Source:MGI Symbol;Acc:MGI:1352447]) HSP 1 Score: 783.867 bits (2023), Expect = 0.000e+0 Identity = 548/1553 (35.29%), Postives = 868/1553 (55.89%), Query Frame = 3
Query: 36 CQDSFWSNSHLQSP--NYPIFTNCFQYTLLIIGPSIFFITFSILLLERLFNKKHLKIITFHSFDLRHSXXXXXXXXXXXXVFAEMLIDNLYTTNKDSMLFISCGXXXXXXXXXXXXTELRRRGNKSIDVILFVFWWM-VFCGYFFRYYSHFIALLQNSKPNRXXXXXXXXXXXXXXXXXXXXDTFLRFPPNLRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKS-SINSEISAQYFHNYGE-REDIFRRASKSEDEEFLIN-------SEEKESFILEHSGKV--------------LIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAF----VFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMD----FGTEFKSFLNES---------SDKVDKNQNNLIQPSA---PNK------RKRSRLSTSGSQGFDGNENAEENYE-----KYFNDISHEEEIM------------SGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQ--AF--GNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
C +FW+ S L+SP + P+ CF+ T+L+ P F + L R++ + K F L + ++ ++ + + L ++ + + + L + V R+ + L +FW + + CG F++ + ALLQ+SK N LF ++ I+ F + T P AS S +T+ W DS + YK +T + +D+ K+ S+ S+ + + R+ + RR KS+ + S+ ++ +LE S K L+K++F + +IL + +L++ DIL+ P +LK L+ + K+ +Y W G +YA V LIQ + +CF L + VR ++I + +K L LS A+ Y+ G+ +N+ VD +++M+ Y +L S QI L++ L+ ELG SI GV ++V ++PV + +K + + KDKR+ I+ EIL+GIK++K + WE SF ++ SIR++EL+N +S IL + L P LV TF+ Y+ ++++AEK F +I LFN ++ P+ +LP ++ I A VS R+ ++L S+++ + + +++ F+W R ++++ L ++ +L+AVVG VG GKSSL+SA+LGEM ++G + +G IAYVPQ+AWIQN T+++NIL +++ Y +V++AC L D+E LP D EIGE+G+NLSGGQK RVSLARA YQD+DIY+LDD LSAVD +VG+ +FNK++ GLL KTR+LVTHG+ +LP VDEI V+ +G I E+G+Y LMD F +K+F+ S +D +++ + + P+ P+ R+ + L + S+ ++ + K N ++ +EE++ +G+V + + Y +A G + S+L VIF VL AF N+WL N + + S+ + I +G +G+ Q + ++ I+ ASK +H LL +LR+ + FF+ TP+GRI+NRF D+ +D TL + + ++++LV+I + TP F I+ IP+ I Y+ +QVFY+++SRQ RRLDS S + +H ET SG +IR+ E + F + + ID + K S RWL +RL+++GNLIVF S + V+ + SL+ VG +S AL +T LNWL R +E ETN V++ERI +Y + E+ T+ +W G I N+ ++Y L VLK IT NI EK+GVVGRTGAGKSSL LFR++E G+I IDG++I SIGLH LR +LTI+PQDP++FSG L+ NLDPF++Y+D+++ ++LE++ + +V L G+ ++ G NLS+GQ+QL+CL R +L+KSKI++LDEATA+VD ETD + I+ +F TVI IAHRL TI+D DKI+ LD G I+E+GSP+ELLSN G F +A+
Sbjct: 5 CNSTFWNLSLLKSPEADLPL---CFEQTVLVWIPLGFLWLLAPWQLYRIY-RSRTKRFAITKFYLAKQVFVVCLLILAAIDLSLALTEDTGQATIPPVKYTNPILYLCTWLLVLVIQHCRQCCIQKNSWFLSMFWILSLLCG-IFQFQTLIRALLQDSKSNMTYSCLFFVSYGFQIVILILS----AFSESSDSTHAPSATASFLSSVTFSWYDSTVLKGYKHPLTIEDVWDIEENLKAKSLTSKFKTIMTKDLQKARQALQRRLKKSQQSPEGTSHGLTKKQSQSQDVLVLEDSKKKKKKSEATKDFPKSWLVKALFKTFYVVILKSFILKLAHDILLFLNPQLLKFLIGFVKDPD-SYPWVGYIYAILMFSVTLIQSFFLQCYFQFCFVL----GMTVRTTIIASVYKKALTLSNLARRQYTIGETVNLMSVDSQKLMDVTNYIHLLWSSVLQIALSIFFLWRELGPSILAGVGLMVLLVPVNGVLATKIRKIQVQNMKNKDKRLKIMNEILSGIKILKYFAWEPSFKEQVNSIRKKELRNLLRFSQLQTILIFILHLTPTLVSVITFSVYVLVDSQNVLNAEKAFTSITLFNILRFPLAMLPMVISSVIQASVSVDRLEQYLGSDDL----DLSAIRHVCHFDKAVQFSEASFTWDRDLEATIQDVNLDIKPGQLVAVVGTVGSGKSSLISAMLGEMENVHGHITIKGSIAYVPQQAWIQNGTIKDNILFGSEYDEKKYQRVIEACALLPDLEMLPGGDMAEIGEKGINLSGGQKHRVSLARATYQDADIYILDDPLSAVDTHVGKHIFNKVVGPNGLLSGKTRILVTHGIHFLPQVDEIVVLG-KGTILEKGSYSDLMDKKGVFAKNWKTFMKHSGPEGEATVDNDSEEEDGDCGLIPTVEEIPDDAASLTMRRENSLRRTLSRSSRSGSRRGKSLKSSLKIKSVNALNKKEEVVKGQKLIKKEFVETGKVKFSIYLKYLQAVGWW----SLLFIVIFYVLNYVAFIGTNLWLSAWTSDSEKQNGTDNSPSQRDMR--IGVFGALGIAQGIFLLSSSLWSIYACRNASKTLHRQLLTNILRAPMSFFDTTPTGRIVNRFAGDISTVDDTLPQTLRSWLLCFFGIVSTLVMICMATPIFIIIIIPLSILYVSVQVFYVATSRQLRRLDSVTKSPIYSHFSETVSGLPVIRAFEHQQRFLANSEKQIDTNQKCVFSWITSNRWLAIRLELVGNLIVFCSALLLVIYKNSLTGDTVGFVLSNALNITQTLNWLVRMTSEVETNIVAVERINEYINVDNEAPWVTDKKPPADWPKKGEIQFNNYQVRYRPELDLVLKGITCNIKSTEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDIASIGLHDLRGRLTIIPQDPILFSGNLRMNLDPFNKYSDEEIWRALELAHLKSFVAGLQLGLLHEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRNEFSQCTVITIAHRLHTIMDSDKIMVLDSGKIVEYGSPEELLSN-MGPFYLMAK 1531
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc6 (ATP-binding cassette, sub-family C (CFTR/MRP), member 6 [Source:MGI Symbol;Acc:MGI:1351634]) HSP 1 Score: 663.685 bits (1711), Expect = 0.000e+0 Identity = 431/1322 (32.60%), Postives = 703/1322 (53.18%), Query Frame = 3
Query: 591 PPNLRETKHP-----EIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRAS---KSEDEEFLINSEEKESFILEHSGK--VLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYS---WILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQ-------NNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFND------ISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISEN-WVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
PP E P E AS S+ + W ++ YK + K DL S + + + E+ +Q ERE +RR+ + + E E+F+ + L+++I+ L+ L ++ D +P +L L L + ++ + W G L A + + ++FE + +R+R ++ G++ RK L LS+ ++ + +AGD++N+ VD++++ I+Y W+L I + V L+ LG S VA+ ++++P+ I + + E+++ K R + + +L ++ IK + WE +F ++ IR +EL + ++ + + V F + FLV F + + + AEK F+ + + + + LP+ V + A VSF R+ FL E+ P + ++ S I + NG F+W++ P L I LTV + L+AVVG VG GKSSLLSA+LGE+ + G+V EG +AYVPQEAW+QN ++ N+ + + + KVLDAC L D+ S P T IGE+G+NLSGGQKQR+SLARAVY+ + IYLLDD L+A+D +V Q +F ++I GLL+ TR+LVTH L LP D I V+ + G I+E G+Y+ L+ L+ + + P R R + + G +E E +D + E+ + GRV + Y +A G + ++ + V WL + AD + + + A +G++G Q + + GG RAS + LL V RS + FF TP G +LNRF+K+ +D + + ++ L+ + +++ TP + +P+++ Y Q Y+++S Q RRL+S S V +H+ ET+ GS ++R+ A++ F + +D++ + + ++ RWL L++LGN +VF + AVL++ LSA LVG S+S ALQVT L W+ R + E + V++ER++ Y IP E+ ++ W G I +F L++ LP ++ +++ I+ GEK+G+VGRTGAGKSSLA L RL E G I+IDGV I +GLH LR ++TI+PQDPV+F G+L+ NLD E+TD+ + +LE + +V SL + Y+C G +LS+GQKQL+CLAR LL+K++I+ILDEATASVD T+ ++ A++ F TV++IAHRL++++DC +++ +D+G + E GSP +LL+ G F LA
Sbjct: 196 PPFFSEDSQPLNPCPEAEASFPSKAMFWWASGLLWRGYKKLLGPK---DLWSLGRENSSEELVSQL-----ERE--WRRSCNGLPGHKGHSSVGAPETEAFLQPERSQRGPLLRAIWRVFRSTFLLGTLSLVISDAFRFAVPKLLSLFLEFMGDRNSS-AWTGWLLAVLMFAAACLQTLFEQQHMYRAKVLQMRLRTAITGLVYRKVLVLSSGSRKSSAAGDVVNLVSVDIQRLAESIIYLNGLWLLF---LWIFVCFVYLWQLLGPSALTAVAVFLSLLPLNFFITKKRGFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWEHAFLERLLHIRGQELSALKTSTLLFSVSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQAFLPFSVHCIVQARVSFDRLAAFLCLEEVDPNGMIA-SNSRRSSKDRISVHNGTFAWSQESPPCLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGSVAYVPQEAWVQNTSVVENVCFRQELDLPWLQKVLDACALGSDVASFPAGVHTPIGEQGMNLSGGQKQRLSLARAVYKKAAIYLLDDPLAALDAHVSQQVFKQVIGPSGLLQGTTRILVTHTLHVLPQADRILVLAN-GTIAEMGSYQDLLQRNGALVGLLDGARQPAGTHDAATSDDLGGFPGGGRPTCRP-DRPRPTEAAPVKGRSTSEVQMEASLDDPEATGLTAEEDSVRYGRVKTTIYLSYLRAVGTPLCTYTLFLFLCQQVASFSQGYWLSLWAD------DPVVDGRQMHAALRGWVFGLLGCLQAIGLFASMAAVFLGGARASGLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDTVDVDIPDKLRSLLTYAFGLLEVGLAVTMATPLAIVAILPLMVLYAGFQSLYVATSCQLRRLESARYSSVCSHMAETFQGSLVVRAFRAQASFTAQHDALMDENQRVSFPKLVADRWLATNLELLGNGLVFVAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYARIPKEAPWRLPTCAAQPLWPCGGQIEFRDFGLRHRPELPLAVQGVSLKIHAGEKVGIVGRTGAGKSSLAWGLLRLQEAAEGNIWIDGVPITHVGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQEHTDEGIWAALETVQLKAFVTSLPGQLQYECAGQGDDLSVGQKQLLCLARALLRKTQILILDEATASVDPGTEMQMQAALERWFTQCTVLLIAHRLRSVMDCARVLVMDEGQVAESGSPAQLLAQ-KGLFYRLAH 1493
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|O35379|MRP1_MOUSE (Multidrug resistance-associated protein 1 OS=Mus musculus OX=10090 GN=Abcc1 PE=1 SV=1) HSP 1 Score: 850.121 bits (2195), Expect = 0.000e+0 Identity = 508/1347 (37.71%), Postives = 788/1347 (58.50%), Query Frame = 3
Query: 594 PNLRETKH-----PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRR------------ASKSEDEEFLINSEEKESFILEHSGK--------VLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL----NESSDKVDKN-------------QNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHE-------EEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
P ET H PE AS S++T+ W+ + + Y+ + S DL S K + E+ +N+ + D R+ SK + L +EE E+ I++ K VL K+ FG +F L++ L + + D+++ P +L+L++N+ +++ W+G Y + + + ++ + F + +R++ +V+G + RK L ++ A+ + + G+I+N+ VD ++ M+ Y ++ S P Q+IL + L+ LG S+ GVA+++ ++P+ + TK Y + KD R+ ++ EILNGIKV+K+Y WE +F +K+ SIRQEELK + + + + PFLV STF ++ +I+ A+K F+++ LFN ++ P+ +LP ++ + A VS R+ FL E+ P S+ + G SI ++N F+W R P L I ++ + L+AVVG+VG GKSSLLSA+L EM + G V +G +AYVPQ+AWIQN++LR NIL + +Y V++AC L D+E LP+ D+TEIGE+GVNLSGGQKQRVSLARAVY +SDIYL DD LSAVD +VG+ +F K++ GLLK+KTR+LVTHG+ +LP VD I V++ G+ISE G+Y+ L+D F FL N D ++ +N ++ K + LS S S D ++ E E ++ +G+V L S+ W Y KA G+F+ SI + V N WL + D ++N + N++ F ++ YG +G+ Q A+ + GG+ AS+++H LL VLRS + FF TPSG ++NRF+K+L +D + I + +I ++++I + TP ++ P+ + Y +Q FY++SSRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV++R SLSA LVGLS+SY+LQ+T LNWL R +E ETN V++ER+++Y+ E+ I ET W +G + ++ L+Y +L VLK+I + I GGEK+G+VGRTGAGKSSL L LFR+ E G I IDGVNI IGLH LR ++TI+PQDPV+FSG+L+ NLDPF +Y+D+++ +LE++ + +V++L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D ++I LD G + E G+P ELL G F ++A+
Sbjct: 196 PLFSETVHDRNPCPESSASFLSRITFWWITGMMVHGYRQPLE---SSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPVRIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKT-FGPYF---LMSFLYKALHDLMMFAGPKILELIINFVNDREAP-DWQGYFYTALLFVSACLQTLALHQYFHICFVSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEP-DSIERRSIKSGEGNSITVKNATFTWARGEPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSG-GKISEMGSYQELLDRDGAFAEFLRTYANAEQDLASEDDSVSGSGKESKPVENGMLVTDTVGKHLQRHLSNSSSHSGDTSQQHSSIAELQKAGAKEETWKLMEADKAQTGQVQL-SVYWNYMKAIGLFITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQANRN-----FRLSVYGALGILQGAAIFGYSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAP--PSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELL-QQRGIFYSMAK 1523
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|Q5F364|MRP1_CHICK (Multidrug resistance-associated protein 1 OS=Gallus gallus OX=9031 GN=ABCC1 PE=2 SV=1) HSP 1 Score: 849.736 bits (2194), Expect = 0.000e+0 Identity = 514/1350 (38.07%), Postives = 785/1350 (58.15%), Query Frame = 3
Query: 579 FLRFPPNLRETKH-----PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRR-------ASKSEDEEFLINSE---EKESFILEHS--------GKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLN---------ESSDKVDKN-------QNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEEN---------YEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVE---SINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
F PP E + PE AS S++T+ W+ + ++ + K DL S K + EI N+ + +R +SK + + N E E E+ I++ S KVL K+ FG +F L++ L + D+L+ T P +LKLL+N+ K W+G Y + + + ++ + F + +R++ +++G+I RK L ++ A+ T + G+I+N+ VD ++ M+ Y ++ S P Q+IL + LL+ LG S+ GVA+++ ++P+ + TK Y ++ KD R+ ++ EILNGIKV+K+Y WE +F K+ IRQ+ELK + + + + PFLV STF Y+ +I+ A+K F+++ LFN ++ P+ +LP ++ + A VS R+ FL E+ P S + +T SI ++N FSW++ P L +I TV + LIAVVG+VG GKSSLLSA+LGEM G V +G IAYVPQ+AWIQN TL +NI+ + N+ Y +V++AC L D+E LP D+TEIGE+GVNLSGGQKQRVSLARAVY ++D YL DD LSAVD +VG+ +F K+I +G+LK+KTRVLVTH + +LP +D I V+ D G+ISE G+Y+ L+ F FL ESSD + +N ++ A K +LS S + + ++ ++ EK ++ + +GRV Y KA G+++ S+ + + N WL + D + N ++ + YG +G+ Q +AV + GG+ AS+ +H LL VLRS + FF TPSG +++RF+K++ ID T+ I + T +I + ++I + TP +V P+ + Y+L+Q FY+++SRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV+ R LS L+GLS+SY+LQ+T LNWL R ++ ETN V++ER+++Y + E SI ET + W G + F L+Y +L VLKNI I INGGEK+G+VGRTGAGKSSL L LFR+ E G I IDG+NI IGLH LR ++TI+PQDP++FSG+L+ NLDPFD+++D+ + +SLE++ + ++V+SL + +N++C G NLS+GQ+QL+CLAR LL+KSKI++LDEATA+VD ETD + IK QF TV+ IAHRL TI+D +++ LD G ++E SP LL + G F ++A+
Sbjct: 191 FPEKPPLFSEAVNDPKPCPEFSASFLSRITFWWITGLMIQGHRRPLEAK---DLWSLNKEDTSEEIVPGLAKNWAKEWAKTKRQPLNMLYSSKKQQKSSDSNGEVMEEAEALIIKPSQRSSEASLSKVLYKT-FGPYF---LMSFLFKAAHDLLMFTGPEILKLLINFVNNKSAP-NWQGYFYTGLLFVCACLQTLILHQYFHICFVTGMRLKTAIVGVIYRKALVITNSARKTSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWRNLGPSVLAGVAVMILLVPINAVMAMKTKTYQVAQMKSKDNRIKLMNEILNGIKVLKLYAWELAFREKVLEIRQKELKVLKKSAYLAAMGTFTWVCAPFLVALSTFAVYVKVNKNNILDAQKAFVSLALFNILRFPLNILPMVISSIVEASVSLKRLRVFLSHEELDPDSIIRGPITNAE--GSIVVKNATFSWSKTDPPSLNSINFTVPEGSLIAVVGQVGCGKSSLLSALLGEMDKKEGYVVVKGSIAYVPQQAWIQNATLEDNIIFGREMNESRYKRVIEACALLPDLEILPMGDRTEIGEKGVNLSGGQKQRVSLARAVYCNADTYLFDDPLSAVDAHVGKHIFEKVIGPKGILKNKTRVLVTHAVNYLPQMDTILVMTD-GEISEMGSYQELLKQDGAFAEFLRTYANAEQSMESSDASSPSGKEGKPVENGVLVNDATGKLMHRQLSNSSTYSRETGKSQHQSSTAELQKPLAEKNSWKLTEADTAKTGRVKATVYWEYMKAIGLYISFLSVFLFMCNHIASLASNYWLSLWTD------DPVVNGTQQYTNVRLGVYGALGISQGIAVFGYSMAVSIGGIFASRHLHLDLLHNVLRSPMSFFERTPSGNLVSRFSKEIDTIDSTIPPIIKMFMGSTFNVIGACIIILLATPIAAVVIPPLGLVYLLVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQKRFIKQNDMKVDENQKAYYPSIVANRWLAVRLEFVGNCIVLFAALFAVIARNKLSPGLIGLSVSYSLQITAYLNWLVRMTSDLETNIVAVERVKEYAEMEKEAEWSIEETAP--ASTWPQEGKVEFRGFGLRYREDLDLVLKNINITINGGEKVGIVGRTGAGKSSLTLGLFRINEAAEGEIIIDGINIAKIGLHDLRFKITIIPQDPILFSGSLRMNLDPFDQHSDEDIWRSLELAHLKNFVSSLPDKLNHECSEGGENLSVGQRQLVCLARALLRKSKILVLDEATAAVDLETDNLIQSTIKSQFEECTVLTIAHRLNTIMDYTRVLVLDRGEVVECDSPDNLL-QAKGLFYSMAK 1520
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|Q8CG09|MRP1_RAT (Multidrug resistance-associated protein 1 OS=Rattus norvegicus OX=10116 GN=Abcc1 PE=1 SV=2) HSP 1 Score: 839.721 bits (2168), Expect = 0.000e+0 Identity = 506/1338 (37.82%), Postives = 785/1338 (58.67%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRR-------------ASKSEDEEFLINSEEKESFILEHSGK--------VLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNE--------SSDKVDKN------------QNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHE-------EEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
PE AS S++T+ W+ + Y+ + S DL S K + E+ +N+ ++E + R +K + L +EE E+ I++ S K VL K+ FG +F L++ L + + D+++ P +L+L++N+ +++ W+G LY + + + ++ + F + +R++ +V+G + RK L ++ A+ + + G+I+N+ VD ++ M+ Y ++ S P Q+ L + L+ LG S+ GVA+++ ++P + TK Y + KD R+ ++ EILNGIKV+K+Y WE +F +K+ +IRQEELK + + + + PFLV STF ++ +I+ A+K F+++ LFN ++ P+ +LP ++ + A VS R+ FL E+ P S + SI ++N F+W R P L I + L+AVVG+VG GKSSLLSA+L EM + G V +G +AYVPQ+AWIQN++LR NIL + + Y V++AC L D+E LP+ D TEIGE+GVNLSGGQKQRVSLARAVY +SDIYLLDD LSAVD +VG+ +F K++ GLLK+KTR+LVTHG+ +LP VD I V++ G+ISE G+Y+ L+D F F+ +S+ KN +N ++ A K + LS S S N+ E + + E ++ +G+V L S+ W Y KA G+ + SI + V N WL + D + +N + ++RN F ++ YG +G+ Q +AV + GG+ AS+++H LL VLRS + FF TPSG ++NRF+K+L +D + I + +I ++++I + TP ++ P+ + Y +Q FY++SSRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV++R SLSA LVGLS+SY+LQ+T LNWL R +E ETN V++ER+++Y+ E+ I ET W +G + ++ L+Y +L VLK+I + I GGEK+G+VGRTGAGKSSL L LFR+ E G I IDG+NI IGLH LR ++TI+PQDPV+FSG+L+ NLDPF +Y+D+++ +LE++ + +V++L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF STV+ IAHRL TI+D ++I LD G I E G+P ELL G F ++A+
Sbjct: 209 PESSASFLSRITFWWITGMMVQGYRQPLK---SSDLWSLNKEDTSEEVVPVLVNNW-KKECVKSRKQPVRIVYAPPKDPTKPKGSSQLDVNEEVEALIVKSSHKDRDPSLFKVLYKT-FGPYF---LMSFLYKALHDLMMFAGPEILELIINFVNDREAP-DWQGYLYTALLFVSACLQTLALHQYFHICFVTGMRIKTAVVGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVTLALYFLWLNLGPSVLAGVAVMILMVPFNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMNIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDEKNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERWSIKDGGGMNSITVKNATFTWARDEPPTLNGITFAIPDGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGRPLQEHCYKAVMEACALLPDLEILPSGDLTEIGEKGVNLSGGQKQRVSLARAVYCNSDIYLLDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSG-GKISEMGSYQELLDRDGAFAEFVRTYANTEQDLASEDDSKNGVSGLGKESKPVENGILVTDAVGKPLQRHLSNSSSHSVVTNQQHSSTAELQKSGVKEETWKLMEADKAQTGQVKL-SVYWNYMKAIGLCISFLSIFLFLCNHVSALASNYWLSLWTDDRPAVNGT--QENRN---FRLSVYGALGILQGVAVFGYSMAVSIGGIFASRRLHLDLLQNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEASWQIQETAP--PSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTIMDYTRVIVLDKGEIRECGAPSELL-QQRGVFYSMAK 1527
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|Q864R9|MRP1_MACFA (Multidrug resistance-associated protein 1 OS=Macaca fascicularis OX=9541 GN=ABCC1 PE=1 SV=1) HSP 1 Score: 833.173 bits (2151), Expect = 0.000e+0 Identity = 507/1350 (37.56%), Postives = 779/1350 (57.70%), Query Frame = 3
Query: 594 PNLRETKH-----PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRR-----------ASKSEDEEFLINSEEKESFILEHSGK--------VLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLN---ESSDKVDKNQNNLIQPSAPNKRKRSR------LSTSGSQ---------GFDGNENAEENYEKYFN-DISHEEEI---------MSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
P ET H PE AS S++T+ W+ I Y+ + DL S K + ++ N+ + R+ ++ +D + +EE E+ I++ K VL K+ FG +F L++ + + D+++ + P +LKLL+N+ + K W+G Y + + + ++ + F + +R++ +VIG + RK L ++ A+ + + G+I+N+ VD ++ M+ Y ++ S P Q+IL + LL+ LG I GVA++V ++PV + TK Y + KD R+ ++ EILNGIKV+K+Y WE +F +K+ +IRQEELK + + + + PFLV TF Y+ +++ A+K F+++ LFN ++ P+ +LP ++ + A VS R+ FL E+ P S V SI ++N F+W R P L I ++ + L+AVVG+VG GKSSLLSA+L EM + G V +G +AYVPQ+AWIQN++L+ NIL + +Y V+ AC L D+E LP+ D+TEIGE+GVNLSGGQKQRVSLARAVY ++DIYL DD LSAVD +VG+ +F +I +G+LK+KTR+LVTH + +LP VD I V++ G+ISE G+Y+ L+ F FL + + D N + S P K + ++G Q + G+ + + N D + +EE +G+V L S+ W Y KA G+F+ SI + V N WL + D + N ++ K ++ YG +G+ Q +AV + GG+ AS+ +H LL ++LRS + FF TPSG ++NRF+K+L +D + I + +I + +VI + TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V +H ET G S+IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV++R SLSA LVGLS+SY+LQVT LNWL R +E ETN V++ER+++Y+ E+ I ET NW G + N+ L+Y +L VL++I + INGGEK+G+VGRTGAGKSSL L LFR+ E G I IDG+NI IGLH LR ++TI+PQDPV+FSG+L+ NLDPF +Y+D+++ SLE++ + +V++L + ++++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D ++I LD G I E+G+P +LL G F +A+
Sbjct: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGS---DLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKDSSKVDANEEVEALIVKSPQKEWNPSLFKVLYKT-FGPYF---LMSFFFKAIHDLMMFSGPEILKLLINFVNDT-KAPDWQGYFYTALLFVAACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWRNLGPPILAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALCTFAVYVTIDKNNVLDAQKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGDTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVALKGSVAYVPQQAWIQNDSLQENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYCNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG-GKISEMGSYQELLARDGAFAEFLRTYASAEQEQDPEDNGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDVSRQHNSTAELQKDGAKKEETWKLMEADKAQTGQVKL-SVYWDYMKAIGLFISFLSIFLFICNHVAALASNYWLSLWTD------DPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAP--PSNWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIARIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKGFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL-QQRGLFYNMAR 1526
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|O15438|MRP3_HUMAN (Canalicular multispecific organic anion transporter 2 OS=Homo sapiens OX=9606 GN=ABCC3 PE=1 SV=3) HSP 1 Score: 830.476 bits (2144), Expect = 0.000e+0 Identity = 506/1366 (37.04%), Postives = 784/1366 (57.39%), Query Frame = 3
Query: 579 FLRFPP-----NLRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSE--------DEEFLINSE---EKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFL---IQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL-NESSDK--------------VDKNQNNLIQPSAPNK------------------RKRSRLSTSG-SQG-------FDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFG----NVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES--INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
F PP N+ +PE A S+L + W Y+ + +K + L ++S + + Q + ++E R S ++E L+ + K SF+ K L+ + FG+ F LI+ ++++D+L P +L +L+ + W ++ +FL +Q LI + +Y F ++ R ++G+I RK L ++ K + G+I+N+ VD ++ M+ + +L S P QIIL + L+ LG S+ GVA +V +IP+ A+ + + K++ KD R+ +++EILNGIKV+K+Y WE SF ++E IRQ EL+ R + + PFLV T Y+Y P +++ AEK F+++ LFN ++LP+ +LP ++ A VS RI +FL E+ P+S + +SPG +I I +G F+W + P L ++ + V K L+AVVG VG GKSSL+SA+LGEM L G V +G +AYVPQ+AWIQN TL+ N+L K+ N Y + L+AC L D+E LP DQTEIGE+G+NLSGGQ+QRVSLARAVY D+DI+LLDD LSAVD +V + +F+ +I +G+L KTRVLVTHG+ +LP D I V+ D GQ+SE G Y L+ F +FL N + D+ + + LI+ + N R+ S LS+ G QG +E + K ++ EE+ G V L S+ W Y KA G+ + LA + V Q+ NVWL + N++ + +N+ + Y +G+ Q V+L GG++A++ +H LL +RS FF+ TPSGRILN F+KD++++D L I ++N I++LVVI TP F +V +P+ + Y L+Q FY ++SRQ +RL+S + S + +H ET +G+S+IR+ DFE I +D + + +S RWL + ++ +GN +V + +FAV+ R SL+ LVGLS+SY+LQVT LNW+ R ++ E+N V++ER+++Y+ E+ + E + E W G + N+S++Y L VL++++++++GGEK+G+VGRTGAGKSS+ L LFR++E G I IDG+N+ IGLH LR QLTI+PQDP++FSGTL+ NLDPF Y+++ + +LE+S + +V+S G+++ C G NLS+GQ+QL+CLAR LL+KS+I++LDEATA++D ETD + I+ QF + TV+ IAHRL TI+D +++ LD G + EF SP L++ + G F +A+
Sbjct: 190 FREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQM---VVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL-----KALLAT-FGSSF---LISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFV----TGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQS---VERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLAD-GQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVEL-SVFWDYAKAVGL----CTTLAICLLYVGQSAAAIGANVWL------SAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVE-GSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIA-ARGIFYGMAR 1522
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: R7VJB8 (Uncharacterized protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_229313 PE=4 SV=1) HSP 1 Score: 875.159 bits (2260), Expect = 0.000e+0 Identity = 549/1493 (36.77%), Postives = 848/1493 (56.80%), Query Frame = 3
Query: 18 NCTLCLCQDSFWSNSHLQSPNYPIFTNCFQYTLLIIGPSIFFITFSILLLERLFNKKHLKIITFHSF-DLRHSXXXXXXXXXXXXVFAEMLIDNLYTT--------NKDSMLFISCGXXXXXXXXXXXXTELRRRGNKSIDVILFVFWWMVFCGYFFRYYSHFIALLQNSKPNRXXXXXXXXXXXXXXXXXXXXDTFLRFPPNL------RETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGN--PVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL-----NESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFND---ISHEEEIMSGRVSLNS--------IVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAK--FYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES---INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDK 4382
NCT+ W H P+F CFQ + + GP F LLL +F +L II F + + ++ + L+ + + NL+ T N + IS + + + V + R+ +LF+FW + +YS + + F+ + +V +IL F P + RE PE+ AS S++T+ W++S + YK + ++ + L+ +I++ FH F + K E ++ + K++ I + S + ++G +LIA L + V D+L P++ LL+ Y E WKG LYA +F I ++ SVF + F + + +RV+ ++I I +K L +S EA+ T + G+I+N+ VD +++ + + Y W++ S P QI++ V +L+ +G S+ G+A+++ +IP+ + + +K +++ KD+R+ ++ E+L GIKV+K+Y WE SF +K+ IR +E++ + Y+ + + PFLV ++F Y+ + + A+ F+++ LFN ++ P+ ++P V+ +TA VS RIG+FL + +I ++ V+ A I ++NG F+W + P+LK+I L V+ L AVVG VG GKSSL+SAILGEM + G V G AYVPQ+AWIQN +LR+NIL K F+ Y KV++AC L D+E LP D TEIGE+G+NLSGGQKQRVSLARAVY D DIYLLDD LSAVD +VG+ +F+ ++ +GLL+ KTR+LVTHG+ WLP VDE+ VI + G+ISE+G+YE L+ F FL E+SD D++++ + +R R +T G + EE D + +E GRV + + Y KA G+F+ +L+ +++ N+WL + L N S N ++ + Y+ YG +G+ Q V+L+ +RA+ K+H +L +LRS + FF+ TP GRILNRF++D+ +D+ L I +N +++++ VIS TP F V IP++I Y +Q FYI +SRQ +R++S S + H ET +G+S IR+ +A+ F + +D + F S RWL RL+ +G L+V + IFAV+ + +LS LVGLSISYALQVT LNW+ R ++ ETN VS+ERI +Y+ P E+ + + IS W G + E++S +Y + VL+ IT NI GEK+G+VGRTGAGKSSL ++LFR++E G I IDG+N++ +GLHQLR +LTILPQDPV+F+GTL+ NLDPFD+YTDDKL SL+ + + +++ SL G+ Y+CG G NLS+GQ+QL+CLARTLL+K+KI+ILDEATA+VD ETD + I+ F S T++ IAHRL TI+D D+
Sbjct: 6 NCTV------IWDAPH------PVFPLCFQDSACVWGPCGF------LLLTSVF---YLPIINFQYLTNPSPTSRLFVAKQVICLLLVAVALANLFKTAFEMSNHLNPPILSLISPIVQAVTFLVVMLSIHFERQKGFITSGVLFIFWTLFAVAGIIPFYSKVLEAVHEHPLVDEFRFITFFLHYALVLVQLILCCFTDSAPRMYGNFSNREM-CPEVSASFISRITFFWINSLVRTGYKKSLKEEDVWALNP-------RDITSNTFHP-------FEKQWKKELQKCNWKASLKKA-IPDPSLFATLTKVYGP---TLLIAHLCKFVCDLLTFVGPMLQSLLIEY-TETPDMPEWKGYLYAALFFITTVLTSVFFHQLFHIGMTLGMRVKAALIAAIYKKALTMSNEARKTSTVGEIVNLMSVDAQRMQDVVGYLWMVWSSPLQIVIAVYMLWNIMGPSVLAGLAVMILLIPINGVLASIQRKLQIQQMHLKDQRIKLMNEVLGGIKVLKLYAWELSFKDKVNEIRTKEMQTLKKYAYLGAVGTFTWTCAPFLVTLASFATYVLL--GNNLDADTAFVSLSLFNILRFPINMMPNMVSYMVTASVSIKRIGRFLATGDIDLKN----VLHNSRADAPITVENGNFAWGMGEDDLPILKDIDLQVKDNSLTAVVGAVGAGKSSLISAILGEMEKITGFVNVRGTTAYVPQQAWIQNASLRDNILFGKDFDAQKYNKVIEACALGPDLEILPGGDMTEIGEKGINLSGGQKQRVSLARAVYHDCDIYLLDDPLSAVDSHVGKHIFDHVVGPEGLLRKKTRILVTHGVHWLPKVDEVVVILN-GKISEKGSYEELVSHDGAFAQFLKQYLLQEASDN-DESEDE--------ESRRKRHNTLRQTSLLGQKTVEEKDPDKNKDKERLVQDETSEVGRVRIPCRYLTRDTFYMAYCKALGVFMAIFLLLSFLVYQAASVASNIWLSAWTEDSYLKNESLSNTTQYGKRRDMYLGIYGALGIAQAFFVLLYAMVAAVSQVRAAAKLHEYMLHNILRSPMSFFDTTPIGRILNRFSRDIETVDNLLPQLIRSWLNTFFSVVSTIAVISYSTPIFLSVIIPLVIIYYFVQRFYIPTSRQLKRIESTTRSPIYVHFSETVTGASTIRAFDAQHRFINQSEDKVDHNLSFYFASIASNRWLGFRLEFIGALVVASAAIFAVVGKSTLSGGLVGLSISYALQVTSSLNWMVRMTSDLETNIVSVERINEYSETPPEADWYVQRSAPPIS--WPDEGKVAFEDYSTRYRPGMDLVLRGITANIAAGEKVGIVGRTGAGKSSLTMSLFRIIEAAGGSITIDGLNVSHLGLHQLRSKLTILPQDPVLFAGTLRMNLDPFDQYTDDKLWDSLKNAHLSEFIKSLANGLEYECGEGGQNLSVGQRQLVCLARTLLRKTKILILDEATAAVDLETDELIQRTIRQVFASCTILTIAHRLNTIMDNDR 1439
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: A0A3B4V1F1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1 OS=Seriola dumerili OX=41447 PE=4 SV=1) HSP 1 Score: 874.774 bits (2259), Expect = 0.000e+0 Identity = 516/1329 (38.83%), Postives = 792/1329 (59.59%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEF-----LINSEEKESFILEHSGKVLIKS---------------IFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLY-AFVFL---IQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKR----------------SRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPIL-ICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES-INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQA 4478
PE AS S++T+ W+ + YK + +K + L+ ++S + Q + ++ +E + + NSE KE +E S +++K+ FG +F LI+CL +I++DIL+ P +L+LL+ + Y W+G Y A +F+ +Q LI + + CF +R+R ++IG + RK L +S+ A+ T + G+++N+ VD ++ M+ I Y ++ S P Q++L + L+ LG S+ GVA++V ++PV I TK Y ++ KD R+ ++ E+LNGIKV+K+Y WE +F +K+ IR+ EL+ + + + + PFLV STFT Y+ +++ A+K F+++ LFN ++ P+ +LP ++ + A VS R+ FL S+E SV SP S+ I +G FSW+R +P LK + + + + L+AVVG VG GKSSLLSA+LGEM L GTV +G +AYVPQ+AWIQN+TLR+NI+ + + +Y +V+DAC L+ D+E LP D+TEIGE+GVNLSGGQKQRVSLARAVY D +YLLDD LSAVD +VG+ +F+++I QGLLK KTRVLVTHGL +LP VD I V+ G+++E G+Y+ LM F FL + VD NN I P + K S+LS + +G D N+ A+ N E ++ ++ GRV L+ Y KA G+ + S+L + ++ F N WL + D + N ++ + + YG +GL Q +AV + GG+ AS+ +H +L VLRS + FF TPSG ++NRF K++ ID + + I + ++ + V+I + TP I+ IP L + Y +Q FY++SSRQ +RL+S + S + TH ET G+S+IR+ ++ F + +D + K ++ RWL +RL+ +GN IV + +FAV+ R SLS ++GLSISYALQ+T L WL R ++ ETN V++ER+++Y E+ ++ + W ++G I++ +F L+Y +L ++NI+I INGGEK+G+VGRTGAGKSSL L LFR++EG G IFIDGV+I +GLH LR ++TI+PQDPV+FSG+L+ NLDPFD Y+D+ + ++LE+S + +V+ L + ++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D ++++ LD G + EF SP L++ +K A
Sbjct: 210 PEPGASFLSRITFWWITRMMVTGYKRPLEEKDLWSLNPEDRSQ---RVVPQLVRRWNTE---CQKVKSTEQKTLYSPRQVPNSESKEGRAVEESEILIVKNPQKTKEPSLFWALCLTFGPYF---LISCLYKIIQDILMFVGPEILRLLIRFVNNSSAPY-WQGYFYTALLFICTCVQSLILQKYFHVCFV----SGMRLRTAIIGAVYRKALVISSAARRTSTVGEMVNLMSVDAQRFMDLITYINMIWSAPLQVVLALYFLWQNLGPSVLAGVAVMVLMVPVNAVIAMKTKTYQVAQMKSKDNRIKLMNEMLNGIKVLKLYAWELAFKDKVSEIRESELRVLKKAAYLGAMSTFTWVCAPFLVALSTFTVYVLIDEHNVLDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFL-SHEELQEDSVEHRAAAGSP-HSVSIVDGVFSWSRTESPTLKQMNMCIPEGSLVAVVGHVGSGKSSLLSALLGEMDKLEGTVAVKGSVAYVPQQAWIQNSTLRDNIMFGQERREAWYHRVVDACALQPDLEILPAGDETEIGEKGVNLSGGQKQRVSLARAVYCDRAVYLLDDPLSAVDAHVGKHIFDQVIGPQGLLKDKTRVLVTHGLSYLPQVDLILVMVG-GEVTEMGSYQQLMATEGAFSEFLRTYA-SVDYTDNNEIPPKSGTKGTENGSATALAGSPVVSSVSKLSQTNKEGQDLNKKAK-NPE--VGKLTEADKASIGRVQLSVFWAYLKAIGVLLSCISLLLFLAHHLVSLFSNYWLSLWTD------DPVVNGTQPNRLMRLGVYGGLGLSQGVAVFGYSLSMSIGGILASRVLHQSMLYDVLRSPMSFFERTPSGNLVNRFAKEMDTIDSMIPVIIKMFMGSMFNVLGACVIILVATPLVAII-IPFLGLLYFFVQRFYVASSRQLKRLESVSRSPIYTHFNETLLGTSVIRAFGEQARFICESDQRVDHNQKAYYPGIVANRWLAVRLEFVGNCIVSFAALFAVIARDSLSPGIMGLSISYALQLTASLTWLVRMSSDVETNIVAVERVKEYGDTEKEAEWKHESSPLPPGWPTDGCIDIRSFGLRYRHDLDLAIRNISIKINGGEKVGIVGRTGAGKSSLTLGLFRIIEGAEGHIFIDGVDIAQLGLHDLRSRITIIPQDPVLFSGSLRMNLDPFDSYSDEDVWRALELSHLKAFVSGLPNKLTHECSEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRSQFEDCTVLTIAHRLNTIMDYNRVLVLDKGEMAEFDSPSHLIAQRGAFYKMAKDA 1510
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: K1PDM7 (Multidrug resistance-associated protein 1 OS=Crassostrea gigas OX=29159 GN=CGI_10008106 PE=4 SV=1) HSP 1 Score: 873.618 bits (2256), Expect = 0.000e+0 Identity = 517/1364 (37.90%), Postives = 794/1364 (58.21%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSS---------INSEIS---------------AQYFHNYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKN---YTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGAS--IEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL---------------------NESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGF-------DGNE-----------NAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLN----NSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYI------SENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
PE +SI S+LTY WM+S I N +K D+T+ FDL+ + S + E+S AQ+ ER + +S++ I +K+ + G L K + + L A + + D+L + P +L +L+ Y + K N Y WKG +YA F + L+ S F + F + + +R+R ++I + +K+L ++ EA+ T + G+I+N+ VD +++ + Y W++ S P QI L + LL+ +LG S+ G+ +++ +IPV I +K + +KDKR+ +++E+LNG+KV+K+Y WE SF +KI+ IR +E + ++ + F PFLV TF Y++ +SA+K F ++ LFN ++ P+ LLP ++ I A VS GRI KFL + ++ P + Q P + + ++NG FSW P L+++ + + KL+AVVG+VG GKSSLLSA+LGEM L+G+V G +AYVPQ+AWIQN T+++NIL K + Y +VL+AC L+ D+E L D TEIGE+G+NLSGGQKQRVSLARAVY ++DIY+LDD LSAVD +VG+ +F K++ +GLL++KTR++VTHG+ WLP VD I V+ D G+I+E GTY+ L+ F FL ++ ++V+ ++ S + R R S DG+E ++ K + + EE+ G+V + YF+A G+ + +IF V N+WL + + L N N+T Q+RN ++ Y G+ Q ++++ + + AS+K+H+ +L+ V+++ + FF+ TPSGRI+NRF++D+ D TL + + +N +++ +VIS TP F + +P+LI Y +Q FY+ +SRQ +R++S S + H E+ SG+S IR+ + F + +DK+ + + S RWL RL+ GNLIVF + IFAV+ +LS LVGLS+SYALQVT LN L RQ AE ETN V++ER+++Y+ + E+ +I +W +NG + ++ +Y L VL+ I+ + GG+KIG+VGRTGAGKSSL +ALFRL+E G+I IDG I+ IGLH LR +LTILPQDPV+FSGTL+ N+DPF+ YTD+ + +L+ S + +V L EG+ ++CG G NLS+GQ+QL+CLARTLL+KSKI+ILDEATA+VD ETD + + I+ +F STV+ IAHRL TI+D DK++ LD G + E+ SP LL N + F +A+
Sbjct: 200 PETKSSILSRLTYWWMNSLIINAFKKDLTEDDLFDLNPRDASDRVIPQFEEQWDKEVSKYRKTEQNVTFQVGKAQHHLQASERTPLVGTSSRTYSTTVEIKDPKKK----QQEGASLFKVLAKTYGPDFLKAWGCKFLYDLLQMASPSLLSVLIEYVENKNINKNEYEWKGYVYALGFFLIALLQSTFFHQNFHIGMTLGMRIRSALIAAVYKKSLTMNNEARKTSTVGEIVNLMSVDCQRMQDLSGYLWMIWSAPVQITLAMYLLWIQLGPSVLAGLGLMLLLIPVNAVISMKQRKLQVDLMKFKDKRLKLMSEVLNGMKVLKLYAWEPSFQDKIQEIRTKETNILKKNALYSAFSSFSFTTAPFLVTLVTFLTYVFTSDTGYLSAQKAFTSLALFNILRFPINLLPMMISYVIQANVSIGRISKFLKNGDLDPNA------VQHEPKSDSVVSVENGTFSWDSELQPALRDVNIKIPAGKLVAVVGQVGSGKSSLLSALLGEMDKLSGSVNVYGNVAYVPQQAWIQNATVKDNILFGKHMEEGKYDEVLEACALKTDLEILTGGDMTEIGEKGINLSGGQKQRVSLARAVYNNADIYMLDDPLSAVDSHVGKHIFQKVVGAKGLLRNKTRIMVTHGVHWLPLVDSIIVLID-GKITEMGTYDELLSHDGAFAQFLKTYLTQENPDEEEDEEIEQMKSKILERVESVTSDTGATSGEEGKARKRKDKSAKAPLARSISTIDGSELPGKDKKDVKAPGDQPKMKEKDKLIQEEKAEKGKVKWKVFMMYFRAIGMAASAIILAIFIIFQVSSVGANIWLSIWTTDKELANISLANTTEYQNRNY--MFLGIYAAFGVVQGAVIMIYTLLATYKMVDASRKLHNAMLENVMKAPMSFFDTTPSGRIVNRFSRDVETTDSTLPMVLRMWMNMFFSTLSTFIVISYSTPLFMTIIVPVLIFYFAVQRFYVPTSRQLQRIESTTRSPIFNHFSESLSGASSIRAYYEQERFINESLSRVDKNILYYFARIASNRWLGWRLEFAGNLIVFAAAIFAVVTP-NLSGGLVGLSVSYALQVTSALNMLVRQTAELETNVVAVERLKEYSEVETEA-----EWIRPFRRPPHDWPANGGVIFHDYKTRYREGLDLVLRGISFQVLGGQKIGIVGRTGAGKSSLTVALFRLIESAGGQIVIDGQRISDIGLHDLRGKLTILPQDPVLFSGTLRMNIDPFNAYTDENIWHALQHSHLKAFVEGLPEGIQHECGEGGQNLSVGQRQLVCLARTLLRKSKILILDEATAAVDMETDDLIQKTIRTEFKDSTVLTIAHRLNTIMDYDKVLVLDQGLVKEYDSPDNLLKNKTSVFYGMAK 1544
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: A0A091GNP1 (Multidrug resistance-associated protein 1 (Fragment) OS=Cuculus canorus OX=55661 GN=N303_11864 PE=4 SV=1) HSP 1 Score: 871.692 bits (2251), Expect = 0.000e+0 Identity = 515/1348 (38.20%), Postives = 799/1348 (59.27%), Query Frame = 3
Query: 579 FLRFPPNLRETKH-----PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGE------REDI-----FRRASKSEDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHII----LIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL------NESSDKVDKN----------QNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEEN---------YEKYFNDISHEEEIMSGRVSLNSIVW-YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVE---SINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
F PP ET + PE AS S++T+ W+ + Y+ + K + LH +KS EI N+ + R+ + ++ KS D + + +EE E+ I++ S K S+F A + L++ L + D+L+ P +LKLL+N+ K W+G Y + + + ++ + F + +R++ +V+G+I RK L ++ A+ T + G+I+N+ VD +++M+ Y ++ S PFQ+IL + LL+ LG S+ GVA+++ ++P+ + TK Y ++ KD R+ ++ EILNGIKV+K+Y WE +F K+ IRQ+ELK + + + + PFLV STF Y+ +I+ A+K F+++ LFN ++ P+ +LP ++ + A VS R+ FL E+ P S + +T+ I ++N FSW++ P L +I TV + LIAVVG+VG GKSSLLSA+LGEM G V +G +AYVPQ+AW+QN TL++NI+ + N+ Y +V++AC L DIE LP D+TEIGE+GVNLSGGQKQRVSLARAVY ++D+YL DD LSAVD +VG+ +F K+I +G+LK+KTRVLVTH + +LP +D I V+ +G+ISE G+Y+ L+ F FL +S + D N +N ++ AP K +LS S + D ++ +++ EK ++ + +GRV + ++ W Y KA G+F+ S+ + + N WL + D + N ++ + YG +G Q +AV + GG+ AS+ +H LL +VLRS + FF TPSG ++NRF+K++ ID T+ I + T +I + ++I + TP ++ P+ + Y+ +Q FY+++SRQ +RL+S + S V +H ET G ++IR+ E + F +D++ K ++ RWL +RL+ +GN IV + +FAV+ R LSA LVGLS+SY+LQ+T LNWL R +E ETN V++ER+++YT + E SI +T + W G + + L+Y +L VLKNI + INGGEKIG+VGRTGAGKSSL L LFR+ E G I IDG+NI IGLH LR ++TI+PQDPV+FSG+L+ NLDPFD+++D+ + +SLE++ + ++V+SL + +N++C G NLS+GQ+QL+CLAR LL+KSKI++LDEATA+VD ETD+ + IK QF TV+ IAHRL TI+D +++ L+ G ++E GSP+ LL G F ++A+
Sbjct: 178 FPERPPLFSETVNDPNPCPEFSASFLSRITFWWITGLMVQGYRRPLEAKDLWSLHKEDKSE---EIVPGLARNWAKEWAKTKRQPLNMLYSLKKQQKSSDSKGDV-TEEAEALIIKPSQKSSEASLFKALYKTFGPYFLMSFLFKAAHDLLMFAGPEILKLLINFVNNKAAP-DWQGYFYTGLLFVCACLQTLILHQYFHICFVTGMRLKTAVVGVIYRKALVITNSARKTSTVGEIVNLMSVDAQRLMDLATYINMIWSAPFQVILALCLLWQNLGPSVLAGVAVMILLVPINAVMAMKTKTYQVAQMKCKDNRIKLMNEILNGIKVLKLYAWELAFREKVLEIRQKELKVLKKSAYLAAMATFTWVCAPFLVALSTFAVYVTTDKKNILDAQKAFVSLALFNILRFPLNMLPMVISSIVEASVSLKRLRVFLSHEELDPDSIIRGPITEAE--GCIVVKNATFSWSKNDPPSLNSINFTVPEGSLIAVVGQVGCGKSSLLSALLGEMDKKEGYVVVKGSVAYVPQQAWVQNATLQDNIIFGREMNENRYKRVIEACALIPDIEVLPTGDKTEIGEKGVNLSGGQKQRVSLARAVYCNADVYLFDDPLSAVDAHVGKHIFEKVIGPKGILKNKTRVLVTHAVNYLPQMDTILVMT-EGEISEMGSYQDLLKQDGAFAEFLRTYANTEQSMENSDTNSPSGKEGKPVENGVLVNEAPGKLIHRQLSNSSTCSRDTGKSQQQSSTAELQKPLAEKNSWKLTEADTAKTGRVKV-TVYWDYMKALGLFISSFSVFLFMCNHIAALASNYWLSLWTD------DPVVNGTQQYTNVRLGVYGALGTSQGIAVFGYSMAVSIGGIFASRHLHLNLLHSVLRSPMSFFERTPSGNLVNRFSKEIDTIDSTIPPIIKMFMGSTFNVIGACIIILLATPIAAVIIPPLGLVYLFVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGVTVIRAFEEQKRFIKQNDMKVDENQKAYYPSIVANRWLAVRLEFVGNCIVLFAALFAVMARNKLSAGLVGLSVSYSLQITAYLNWLVRMSSELETNIVAVERVKEYTEMEKEAEWSIEQTAP--ASTWPEEGKVEFRGYGLRYREDLDLVLKNINVTINGGEKIGIVGRTGAGKSSLTLGLFRINEAAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFDQHSDEDIWRSLELAHLKNFVSSLPDKLNHECAEGGENLSVGQRQLVCLARALLRKSKILVLDEATAAVDLETDQLIQSTIKSQFKECTVLTIAHRLNTIMDYTRVLVLERGKVVECGSPEHLL-QEKGIFYSMAK 1507
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: A0A2T7P461 (Uncharacterized protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_10785 PE=4 SV=1) HSP 1 Score: 866.3 bits (2237), Expect = 0.000e+0 Identity = 514/1345 (38.22%), Postives = 788/1345 (58.59%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSS------INS-----EISAQYFH----NYGEREDIFRRASKS------EDEEFLINSEEKESFI---LEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKR---------------------KRSR-LSTSGSQGFDGNENAE----ENYEKYFND-ISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLN------NSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESI-NETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQA 4478
PE +S S+LT+ W++ + +++ +T++ DL+ E SS +N+ ++ Q FH N +R F R + S E ++ ++ +E F EH L+K + +L + + ++ D LILT PLVL L+ F E + W+G + A V + + S+F + + L+ + +R+R ++I + RK L ++ A+ + G+++N+ VD E + + Y + + S P QI +++ LLY LG S+F G+AM++ +IP+ +M + + KD RM ++ E+LNGIK++K+Y WE F +I S+R +EL +YS+ + + + P+ V TF +IY +S + F+AI LFN ++ + P +T I AVVS R+ ++L +++ P+S +V +I I NG F W PVLK+I + + L+AVVG+VG GKSSL+SA++G+M + G V +G +AYV Q+AWIQN+T+RNN+L + + FY L AC L +D+ LP D TEIGERG+NLSGGQKQRVSLARA+Y D+DIYLLDD LSAVD +VG+ +F +I + GLLK+KTRVLVTHG+ WLP VD++ V+ D G +SE G+YE L+ F FL + DKN+ P R KR R +S SG + + + E K+ D + EE++ GRV L++ Y ++ G F ++ +++ N+WL D Q L N NST +RN+ +Y+ YG +G GQ L V ++ F + AS+ IH +L +L + + FF+ TP GRI+NRF+KD+ ID L L ++ +++++L+VIS TP+F + +P+ YI +Q FYIS+SRQ +RL+SK S V ET SG+SIIR+ ++ F R +D + FK Y + RWL RL+ LGN++V + AV + ++S +VGLS+SYAL++T LNWL R ++ ET VS+ER+++Y+ I E+ + + ++W +G + + N S++Y + VLKNI+ I+ GEK+G+VGRTGAGKSSL L+LFRL+E G+I +D +NI +GLH LR +LTILPQDPVIF+G+L+ NLDPFDEY+D ++ +LE + + +V+SL + + ++CG G NLS+GQ+QL+CLAR+LL+K+KI+ILDEATA+VD ETD + + I+ +F TV+ IAHRL T++D DKI+ LD G I E +P+ LL N F +A +
Sbjct: 74 PETQSSFLSRLTFWWVNGLLLQGFRMPLTEENMTDLNPREMSSTVVPRFLNNWKRELSLARQRFHKNQHNKAQRRSSFYRDTGSLIMDADETTPLIVTNKHQEDFKGKKPEHPSPSLLKILVKTFGVQLLQSHVWKLFYDALILTNPLVLGQLIE-FIEDSDSEPWRGYVLALVLFLSMQLQSLFFHQLWHLSTSLGLRIRTTIISAVFRKALTMNNLARQESTVGEVVNLMSVDAEHLEQTVAYLYSIWSSPLQICVSLYLLYATLGPSMFAGLAMLILLIPINGLVMSRLGSLMTQLMAQKDNRMKLINEVLNGIKILKLYAWELPFSKQIGSVRDKELNILWSYSLWSAGMTFSWTVAPYAVSLVTFITFIYTKEDHYLSPQTAFVAIALFNVLRFAINFAPMIITDVIKAVVSLRRLNRYLSHDDLDPKS----IVHDPHSAYAISICNGTFMWNLELGPVLKDINVDIPVGSLVAVVGQVGSGKSSLMSAMIGDMEKIEGQVMVKGTLAYVSQQAWIQNDTVRNNVLFGQVMEQNFYNACLSACALTHDLSILPAGDLTEIGERGINLSGGQKQRVSLARAIYNDADIYLLDDPLSAVDSHVGKHIFENVIGSNGLLKNKTRVLVTHGVHWLPLVDKVFVMKD-GCVSEAGSYEELLSHNGPFAQFLKTYFLQEDKNEEE--DPEVQEMRRKVLERLESVTDKESEDKTVIKRERQVSASGDGKLEAKDEKDKEGTEGLPKHGKDKLIEEEKVAVGRVRLDTFKEYARSLGYGYFLIVVITYIMYEACAVLSNIWLSEWTDDQELNNFTVFPANSTARMNRNN--YYLILYGSLGGGQFLFVAVYSVIESFRTVHASRIIHQKMLTRILHAPMGFFDTTPVGRIVNRFSKDINTIDTELPLTFLMTLDTFCVVLSTLIVISYSTPYFLVAILPLAALYIFIQRFYISTSRQLKRLESKTCSPVYNLFSETLSGASIIRAFGKQNRFIEESDRRVDLNQNFKFYSYSANRWLGFRLEFLGNIVVLCAATIAVAVKDTVSGGIVGLSVSYALEITTNLNWLVRVISDLETQVVSVERVKEYSEIITEAPWSIPGHRPPQSWPQHGEVKVANLSVRYRPEMDLVLKNISFAISAGEKVGIVGRTGAGKSSLTLSLFRLLEPAEGQIHVDNINIADLGLHDLRSKLTILPQDPVIFAGSLRMNLDPFDEYSDAQVWTALEHAHLNAFVSSLPDQLQHECGEGGENLSVGQRQLLCLARSLLRKTKILILDEATAAVDMETDDLIQQTIRTEFADCTVLTIAHRLNTVLDYDKILVLDKGQIAELDTPESLLRNHESIFYQMASS 1408
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: abcc1 (ATP binding cassette subfamily C member 1 [Source:NCBI gene;Acc:103043969]) HSP 1 Score: 852.818 bits (2202), Expect = 0.000e+0 Identity = 503/1322 (38.05%), Postives = 774/1322 (58.55%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKS-SINSEISAQYFH--NYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKS---------------IFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLI----QGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNK------------RKRSRLSTSGS----QGFDGNE-NAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES-INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFK 4463
PE AS S++++ W+ + YK + +K + L++ ++S ++ ++ ++ H + G+R D S +E+K+ +E S +LIK+ FG +F L++ + +I+ D+L+ P +L+LL+ + + +W G Y + + Q LI + + CF +R+R +++G + RK L ++ A+ T + G+I+N+ VD ++ M+ I Y ++ S P Q+IL + L+ LG S+ GVA++V ++PV I TK Y ++ KD R+ ++ E+LNGIKV+K+Y WE +F +K+ +IR+ EL+ + + I + PFLV STF Y+ +++ A+K F+++ LFN ++ P+ +LP ++ + A VS R+ FL E+ S +T SI I +G FSW++ P LK I + + + L+AVVG VG GKSSLLSA+LGEM+ G V +G +AYVPQ+AWIQN TLR NI+ + + +Y KVL+AC L D+E LP D TEIGE+GVNLSGGQKQRVSLARAVY D +YLLDD LSAVD +VG+ +F K+I QG+L+ +TRVLVTHGL +LP D I V+ D G+I+E G+Y L++ F FL ++ + + + AP K + +S L+T G+ Q + N+ A++ ++ ++ +GRV L Y KA G+F+ SIL + V N WL + D + N ++ S + + YG +GL Q +AV + GG+ AS+ +H +L VLRS + FF TPSG ++NRF K+ ID + I + ++ S VI I TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V TH ET G+S+IR+ + F R +D + K ++ RWL +RL+ +GN IV + +FAV+ R +LS ++GLSISYALQVT LNWL R +E ETN V++ER+++Y E+ + + W + G+I + NF L+Y +L + +IT+ I GGEK+G+VGRTGAGKSSL L LFR++E G I IDGVNI ++GLH LR ++TI+PQDPV+FSG+L+ NLDPFD Y+D+ + ++LE++ + ++V+ L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D +++ LD G + EF SP L++ +K
Sbjct: 209 PEAGASFLSRISFWWITGLMVQGYKRPLEEKDLWSLNAEDRSHTVVPQLVRRWDHECSKGKRTDDKTMYSPKRPS----MAEKKDGRPVEESEILLIKAPQKSGDPSLFLALCRTFGPYF---LVSSIYKIIHDVLMFVGPEILRLLIQFVNDSDAP-SWHGYFYTALLFVCTCFQTLILQKYFHVCFV----TGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGPSVLAGVAVMVLMVPVNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKDKVSTIRESELRVLKKAAYLGAISTFTWVCAPFLVALSTFAVYVLVDEHNVLDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMKRLRVFLSHEELDENSVDRRAIT--GSADSIRIGDGAFSWSKEDRPALKRINVRIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGDVSIKGSVAYVPQQAWIQNATLRENIMFGQEKKESWYQKVLEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSLARAVYCDCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGVLQGRTRVLVTHGLSFLPQADLILVMVD-GEITETGSYTELLNRQGAFADFLRTYANAEQDGEPDGMTDGAPRKTLENGGPAAVLRQSQSSLNTPGAAKPQQKAESNDTQAKKTKSPDAAKLTEADKANTGRVKLAVFWEYMKAIGVFLSFISILLFLAHHVSSLGSNYWLSLWTD------DPVINGTQPSREMRLGVYGALGLSQGIAVFCYSISVSIGGILASRYLHETMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQLKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIGESDRRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVMARANLSPGIMGLSISYALQVTASLNWLVRMSSEVETNIVAVERVKEYEDTEKEAEWKLEQSSVPAGWPTAGHIEVRNFGLRYREDLELAIHDITVIIEGGEKVGIVGRTGAGKSSLTLGLFRIIEAAQGEICIDGVNIANLGLHDLRSRITIIPQDPVLFSGSLRMNLDPFDGYSDEDVWRALELAHLKNFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGKMAEFDSPASLIAKKGIFYK 1509
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: abcc1 (ATP binding cassette subfamily C member 1 [Source:NCBI gene;Acc:103043969]) HSP 1 Score: 848.581 bits (2191), Expect = 0.000e+0 Identity = 506/1322 (38.28%), Postives = 774/1322 (58.55%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKS-SINSEISAQYFH--NYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKS---------------IFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLI----QGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL----NESSD--------KVDKNQNNLIQPSAPNKRKRSRLSTSGS----QGFDGNE-NAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES-INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFK 4463
PE AS S++++ W+ + YK + +K + L++ ++S ++ ++ ++ H + G+R D S +E+K+ +E S +LIK+ FG +F L++ + +I+ D+L+ P +L+LL+ + + +W G Y + + Q LI + + CF +R+R +++G + RK L ++ A+ T + G+I+N+ VD ++ M+ I Y ++ S P Q+IL + L+ LG S+ GVA++V ++PV I TK Y ++ KD R+ ++ E+LNGIKV+K+Y WE +F +K+ +IR+ EL+ + + I + PFLV STF Y+ +++ A+K F+++ LFN ++ P+ +LP ++ + A VS R+ FL E+ S +T SI I +G FSW++ P LK I + + + L+AVVG VG GKSSLLSA+LGEM+ G V +G +AYVPQ+AWIQN TLR NI+ + + +Y KVL+AC L D+E LP D TEIGE+GVNLSGGQKQRVSLARAVY D +YLLDD LSAVD +VG+ +F K+I QG+L+ +TRVLVTHGL +LP D I V+ D G+I+E G+Y L++ F FL N D K +K Q N ++ +S L+T G+ Q + N+ A++ ++ ++ +GRV L Y KA G+F+ SIL + V N WL + D + N ++ S + + YG +GL Q +AV + GG+ AS+ +H +L VLRS + FF TPSG ++NRF K+ ID + I + ++ S VI I TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V TH ET G+S+IR+ + F R +D + K ++ RWL +RL+ +GN IV + +FAV+ R +LS ++GLSISYALQVT LNWL R +E ETN V++ER+++Y E+ + + W + G+I + NF L+Y +L + +IT+ I GGEK+G+VGRTGAGKSSL L LFR++E G I IDGVNI ++GLH LR ++TI+PQDPV+FSG+L+ NLDPFD Y+D+ + ++LE++ + ++V+ L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D +++ LD G + EF SP L++ +K
Sbjct: 209 PEAGASFLSRISFWWITGLMVQGYKRPLEEKDLWSLNAEDRSHTVVPQLVRRWDHECSKGKRTDDKTMYSPKRPS----MAEKKDGRPVEESEILLIKAPQKSGDPSLFLALCRTFGPYF---LVSSIYKIIHDVLMFVGPEILRLLIQFVNDSDAP-SWHGYFYTALLFVCTCFQTLILQKYFHVCFV----TGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGPSVLAGVAVMVLMVPVNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKDKVSTIRESELRVLKKAAYLGAISTFTWVCAPFLVALSTFAVYVLVDEHNVLDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMKRLRVFLSHEELDENSVDRRAIT--GSADSIRIGDGAFSWSKEDRPALKRINVRIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGDVSIKGSVAYVPQQAWIQNATLRENIMFGQEKKESWYQKVLEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSLARAVYCDCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGVLQGRTRVLVTHGLSFLPQADLILVMVD-GEITETGSYTELLNRQGAFADFLRTYANAEQDGEPDGMTGKKEKLQRNTTFVHFFPRQSQSSLNTPGAAKPQQKAESNDTQAKKTKSPDAAKLTEADKANTGRVKLAVFWEYMKAIGVFLSFISILLFLAHHVSSLGSNYWLSLWTD------DPVINGTQPSREMRLGVYGALGLSQGIAVFCYSISVSIGGILASRYLHETMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQLKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIGESDRRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVMARANLSPGIMGLSISYALQVTASLNWLVRMSSEVETNIVAVERVKEYEDTEKEAEWKLEQSSVPAGWPTAGHIEVRNFGLRYREDLELAIHDITVIIEGGEKVGIVGRTGAGKSSLTLGLFRIIEAAQGEICIDGVNIANLGLHDLRSRITIIPQDPVLFSGSLRMNLDPFDGYSDEDVWRALELAHLKNFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGKMAEFDSPASLIAKKGIFYK 1509
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: ENSAMXT00000030862.1 (canalicular multispecific organic anion transporter 1-like [Source:NCBI gene;Acc:103026251]) HSP 1 Score: 845.499 bits (2183), Expect = 0.000e+0 Identity = 568/1566 (36.27%), Postives = 879/1566 (56.13%), Query Frame = 3
Query: 36 CQDSFWSNSHLQSPNYPIFTNCFQYTLLIIGPSIFFITFSI-----LLLERLFNKKHLKIITFHSFDLRHSXXXXXXXXXXXXVFAEMLIDNLYTTNKDSMLFISCGXXXXXXXXXXXXTELRRRGNKSIDV-ILFVFWWMVFCGYFFRYYSHFIALLQNSKPNRXXXXXXXXXXXXXXXXXXXXDTFLRFPPNLRE--TKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSIN------SEISAQYFH--------------------------NYGEREDIFRRASKSEDEEFLINSEEK-ESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVF----ENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLN---ESSDKVDKNQ-------------------NNLIQPSAPNK--RKRSRLSTSGSQGFDGNENAEENYEKYFND-----ISHEEEIMSGRVSLNSIVWYFKATGIFVFG-SSILACVIFGVLQAF--GNVWLGMLA-DTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHE 4499
C +FW N+ L + P T C + T+L+ P + F+ S+ +L ++ K H+ + + S + S+ + + F E +LFI+ + + S V E RR K++D LF+FW + F + + L + K F + + +V+++L PP+LRE K PE+ A S++T+ W + I+ Y+ + + ++L +EK S N E+ Q N G +D+ +SE E E +S ++ LI SI ++L + +L++V+D+L P +LKLL+ + ++K +TW+G LYA + LI ++ SVF CF K+ +RVR ++ + +K L LS +A+ + G ++ + D ++ + +L SCP QI+L+V L+ ELG S+ G+ +++ ++P+ + +K Y K +M+KDKRM +L EIL+GIK++K+Y WE SF +++ R++EL+ R + + +F P V ++F ++ +I+ AEK F +I LFN ++ P+ +LP ++ + VS R+ KFL ++ + V +S +++ +++G FSW R G+PVLKN+ L V L+AVVG VG GKSSL+SA+LGEM++L+G+V +G +AYVPQ+AW+QN TLR+N+L ++ + +VL+AC LE D++ LP QTEIGE+G+NLSGGQKQRVSLARAVY +DIYLLDD LSAVD +VG+ LF K+I +GLLK KTR+LVTHG+ +LP+VDEI V+ D G +SE G+Y L F FL+ + D D+NQ NN+ + + +K S S S N N + E ++ + E + +GRV + + Y + G +G +S+ A V F AF N+WL D N S++ + + YG +G+ Q V + G + AS+ +HS LL +LR+ + FF+ TPSGR++NRF KD+F +D + + +I + + L+ +LV+I + P F V +P++I Y ++ FY+++SRQ RRLDS + S + + ET SG S+IR+ + F ID + K +S RW+ +RL++LGNL+VF S +FAV++R SL + LVGLSISYAL VT LN L R ++ ET+ VS+ER+++Y IP E+ + +E+W S G I +++ ++Y L VL IT +I+ EKIG+VGRTGAGKSSL LFR++E GRI IDG NI S+GLH LR +LTI+PQDPV+FSG+L+ NLDPF++++D+ + K L+++ + ++VNSL G+ ++ G NLS+GQ+QL+CLAR LL+KSKI+ILDEATA+VD ETD + I+ +F TV+ IAHR+ TI+D +++ LD G I+EFG P LL GHF ALA+ K E
Sbjct: 9 CGSTFW-NASLLNRTDPDLTVCVERTVLVWVP-LGFLWISVPWQLNILFKKNSPKTHISKL-YISKQVLVSLLFLSAVAELASSFGEDYGSEEQKKKNPPVLFINPSIYAVSWLLVMLVHEAVRRREKAVDSGSLFLFWLLQIICEIFPFQTLLRDALNSDKVLDPPHFYLFYVSYGLKLVALMLSAIADVPPDLREMTKKSPEVGAPFLSRITFNWFNRMIFTGYRRPLVQEDMWEL--SEKDSTNFISREFEEMMKQELRKAHSRLQKKKMKMKKISRPEHQQNGLNKGISQDVLVLVDQSEKSEKKSKRENNLDSGEEDYPHSWLILSIAKTFKWVLLESAVLKLVQDLLSFVSPQLLKLLIGFTQDKSV-FTWRGYLYASLLLIVAIVQSVFLQQFTQRCF----KLGMRVRAAISAAVYKKALTLSNDARKESTIGQMVTLMSADAQRFNEVTNFIHLLWSCPVQIVLSVGFLWIELGPSVLAGLLVMILMVPINGLLAIKSKSYQAKCMMYKDKRMKMLNEILSGIKILKLYAWEPSFEAQVQGFRKQELEVMRKSAFLSSVSTFIFFCAPAFVSLASFAVFVSVSTDNILDAEKAFTSISLFNILRTPLGMLPLLISAMVQMSVSNRRLEKFLSREDL----NTGAVQRDLSYSSAVSVRDGTFSWNRDGSPVLKNVSLQVSPGALVAVVGAVGSGKSSLVSALLGEMHSLSGSVNIKGDVAYVPQQAWVQNATLRDNVLFGSDPDERRFCRVLEACALEPDLDLLPAGVQTEIGEKGINLSGGQKQRVSLARAVYSSADIYLLDDPLSAVDAHVGKHLFEKVIGPRGLLKDKTRILVTHGISFLPYVDEIVVLVD-GVVSEVGSYSSLRASKGAFSEFLDTYAKEEDSQDQNQSASGSQQVSVGVEHHDLPLNNIKTEDSVSLLLKKESVKHASNSNRDSQNRNVPQRSEGDADERKGRRLIESETVQTGRVKFSVYLQYLSSMG---WGYASMFAVVYFIQSLAFIGQNLWLSDWTNDALRYPNGSSYPAHIRDMR--VGAYGGLGVAQGFLVFVGTLLLADGAIHASRTLHSRLLSNILRAPMLFFDTTPSGRVVNRFAKDMFTVDELIPTALRSVILKLLELLATLVLICLAVPLFTAVVVPLIIIYHFVERFYLTTSRQLRRLDSVSRSPIYSLFGETVSGLSVIRAFGHQERFLQQNRTTIDNNLKCVCQLIVSNRWMAIRLELLGNLVVFFSALFAVISRDSLDSGLVGLSISYALNVTLTLNALVRMTSQLETHVVSVERVKEYAEIPNEAAWTSERRPAEDWPSEGTIWFQDYKVRYRPQLDLVLHGITCHIHSKEKIGIVGRTGAGKSSLTNCLFRIIEAADGRILIDGENIASMGLHDLRSRLTIIPQDPVLFSGSLRMNLDPFEKFSDEDIWKVLDLAHLKEYVNSLEAGLQHEIAEGGENLSVGQRQLLCLARALLRKSKILILDEATAAVDLETDDLIQTTIRREFSHCTVLTIAHRINTILDSSRVMVLDAGRIVEFGPPDVLL-QKRGHFYALAKDAGICKTE 1553
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: abcc1 (ATP binding cassette subfamily C member 1 [Source:NCBI gene;Acc:103043969]) HSP 1 Score: 845.114 bits (2182), Expect = 0.000e+0 Identity = 502/1336 (37.57%), Postives = 775/1336 (58.01%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKS-SINSEISAQYFH--NYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKS---------------IFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLI----QGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQ--------------------------PSAPNKRKRSRLSTSGS----QGFDGNE-NAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES-INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFK 4463
PE AS S++++ W+ + YK + +K + L++ ++S ++ ++ ++ H + G+R D S +E+K+ +E S +LIK+ FG +F L++ + +I+ D+L+ P +L+LL+ + + +W G Y + + Q LI + + CF +R+R +++G + RK L ++ A+ T + G+I+N+ VD ++ M+ I Y ++ S P Q+IL + L+ LG S+ GVA++V ++PV I TK Y ++ KD R+ ++ E+LNGIKV+K+Y WE +F +K+ +IR+ EL+ + + I + PFLV STF Y+ +++ A+K F+++ LFN ++ P+ +LP ++ + A VS R+ FL E+ S +T SI I +G FSW++ P LK I + + + L+AVVG VG GKSSLLSA+LGEM+ G V +G +AYVPQ+AWIQN TLR NI+ + + +Y KVL+AC L D+E LP D TEIGE+GVNLSGGQKQRVSLARAVY D +YLLDD LSAVD +VG+ +F K+I QG+L+ +TRVLVTHGL +LP D I V+ D G+I+E G+Y L++ F FL ++ + + + P+A ++ +S L+T G+ Q + N+ A++ ++ ++ +GRV L Y KA G+F+ SIL + V N WL + D + N ++ S + + YG +GL Q +AV + GG+ AS+ +H +L VLRS + FF TPSG ++NRF K+ ID + I + ++ S VI I TP I+ P+ + Y +Q FY++SSRQ +RL+S + S V TH ET G+S+IR+ + F R +D + K ++ RWL +RL+ +GN IV + +FAV+ R +LS ++GLSISYALQVT LNWL R +E ETN V++ER+++Y E+ + + W + G+I + NF L+Y +L + +IT+ I GGEK+G+VGRTGAGKSSL L LFR++E G I IDGVNI ++GLH LR ++TI+PQDPV+FSG+L+ NLDPFD Y+D+ + ++LE++ + ++V+ L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D +++ LD G + EF SP L++ +K
Sbjct: 209 PEAGASFLSRISFWWITGLMVQGYKRPLEEKDLWSLNAEDRSHTVVPQLVRRWDHECSKGKRTDDKTMYSPKRPS----MAEKKDGRPVEESEILLIKAPQKSGDPSLFLALCRTFGPYF---LVSSIYKIIHDVLMFVGPEILRLLIQFVNDSDAP-SWHGYFYTALLFVCTCFQTLILQKYFHVCFV----TGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGPSVLAGVAVMVLMVPVNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKDKVSTIRESELRVLKKAAYLGAISTFTWVCAPFLVALSTFAVYVLVDEHNVLDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMKRLRVFLSHEELDENSVDRRAIT--GSADSIRIGDGAFSWSKEDRPALKRINVRIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGDVSIKGSVAYVPQQAWIQNATLRENIMFGQEKKESWYQKVLEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSLARAVYCDCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGVLQGRTRVLVTHGLSFLPQADLILVMVD-GEITETGSYTELLNRQGAFADFLRTYANAEQDGEPDGMTEEGGEQEEESGQSEDGAPRKTLENGGPAAVLRQSQSSLNTPGAAKPQQKAESNDTQAKKTKSPDAAKLTEADKANTGRVKLAVFWEYMKAIGVFLSFISILLFLAHHVSSLGSNYWLSLWTD------DPVINGTQPSREMRLGVYGALGLSQGIAVFCYSISVSIGGILASRYLHETMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQLKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIGESDRRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVMARANLSPGIMGLSISYALQVTASLNWLVRMSSEVETNIVAVERVKEYEDTEKEAEWKLEQSSVPAGWPTAGHIEVRNFGLRYREDLELAIHDITVIIEGGEKVGIVGRTGAGKSSLTLGLFRIIEAAQGEICIDGVNIANLGLHDLRSRITIIPQDPVLFSGSLRMNLDPFDGYSDEDVWRALELAHLKNFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGKMAEFDSPASLIAKKGIFYK 1523
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: ENSAMXT00000043850.1 (canalicular multispecific organic anion transporter 1-like [Source:NCBI gene;Acc:103026251]) HSP 1 Score: 842.417 bits (2175), Expect = 0.000e+0 Identity = 543/1446 (37.55%), Postives = 831/1446 (57.47%), Query Frame = 3
Query: 381 ELRRRGNKSIDV-ILFVFWWMVFCGYFFRYYSHFIALLQNSKPNRXXXXXXXXXXXXXXXXXXXXDTFLRFPPNLRE--TKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSIN------SEISAQYFH--------------------------NYGEREDIFRRASKSEDEEFLINSEEK-ESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVF----ENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLN---ESSDKVDKNQ-------------------NNLIQPSAPNK--RKRSRLSTSGSQGFDGNENAEENYEKYFND-----ISHEEEIMSGRVSLNSIVWYFKATGIFVFG-SSILACVIFGVLQAF--GNVWLGMLA-DTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHE 4499
E RR K++D LF+FW + F + + L + K F + + +V+++L PP+LRE K PE+ A S++T+ W + I+ Y+ + + ++L +EK S N E+ Q N G +D+ +SE E E +S ++ LI SI ++L + +L++V+D+L P +LKLL+ + ++K +TW+G LYA + LI ++ SVF CF K+ +RVR ++ + +K L LS +A+ + G ++ + D ++ + +L SCP QI+L+V L+ ELG S+ G+ +++ ++P+ + +K Y K +M+KDKRM +L EIL+GIK++K+Y WE SF +++ R++EL+ R + + +F P V ++F ++ +I+ AEK F +I LFN ++ P+ +LP ++ + VS R+ KFL ++ + V +S +++ +++G FSW R G+PVLKN+ L V L+AVVG VG GKSSL+SA+LGEM++L+G+V +G +AYVPQ+AW+QN TLR+N+L ++ + +VL+AC LE D++ LP QTEIGE+G+NLSGGQKQRVSLARAVY +DIYLLDD LSAVD +VG+ LF K+I +GLLK KTR+LVTHG+ +LP+VDEI V+ D G +SE G+Y L F FL+ + D D+NQ NN+ + + +K S S S N N + E ++ + E + +GRV + + Y + G +G +S+ A V F AF N+WL D N S++ + + YG +G+ Q V + G + AS+ +HS LL +LR+ + FF+ TPSGR++NRF KD+F +D + + +I + + L+ +LV+I + P F V +P++I Y ++ FY+++SRQ RRLDS + S + + ET SG S+IR+ + F ID + K +S RW+ +RL++LGNL+VF S +FAV++R SL + LVGLSISYAL VT LN L R ++ ET+ VS+ER+++Y IP E+ + +E+W S G I +++ ++Y L VL IT +I+ EKIG+VGRTGAGKSSL LFR++E GRI IDG NI S+GLH LR +LTI+PQDPV+FSG+L+ NLDPF++++D+ + K L+++ + ++VNSL G+ ++ G NLS+GQ+QL+CLAR LL+KSKI+ILDEATA+VD ETD + I+ +F TV+ IAHR+ TI+D +++ LD G I+EFG P LL GHF ALA+ K E
Sbjct: 131 EAVRRREKAVDSGSLFLFWLLQIICEIFPFQTLLRDALNSDKVLDPPHFYLFYVSYGLKLVALMLSAIADVPPDLREMTKKSPEVGAPFLSRITFNWFNRMIFTGYRRPLVQEDMWEL--SEKDSTNFISREFEEMMKQELRKAHSRLQKKKMKMKKISRPEHQQNGLNKGISQDVLVLVDQSEKSEKKSKRENNLDSGEEDYPHSWLILSIAKTFKWVLLESAVLKLVQDLLSFVSPQLLKLLIGFTQDKSV-FTWRGYLYASLLLIVAIVQSVFLQQFTQRCF----KLGMRVRAAISAAVYKKALTLSNDARKESTIGQMVTLMSADAQRFNEVTNFIHLLWSCPVQIVLSVGFLWIELGPSVLAGLLVMILMVPINGLLAIKSKSYQAKCMMYKDKRMKMLNEILSGIKILKLYAWEPSFEAQVQGFRKQELEVMRKSAFLSSVSTFIFFCAPAFVSLASFAVFVSVSTDNILDAEKAFTSISLFNILRTPLGMLPLLISAMVQMSVSNRRLEKFLSREDL----NTGAVQRDLSYSSAVSVRDGTFSWNRDGSPVLKNVSLQVSPGALVAVVGAVGSGKSSLVSALLGEMHSLSGSVNIKGDVAYVPQQAWVQNATLRDNVLFGSDPDERRFCRVLEACALEPDLDLLPAGVQTEIGEKGINLSGGQKQRVSLARAVYSSADIYLLDDPLSAVDAHVGKHLFEKVIGPRGLLKDKTRILVTHGISFLPYVDEIVVLVD-GVVSEVGSYSSLRASKGAFSEFLDTYAKEEDSQDQNQSASGSQQVSVGVEHHDLPLNNIKTEDSVSLLLKKESVKHASNSNRDSQNRNVPQRSEGDADERKGRRLIESETVQTGRVKFSVYLQYLSSMG---WGYASMFAVVYFIQSLAFIGQNLWLSDWTNDALRYPNGSSYPAHIRDMR--VGAYGGLGVAQGFLVFVGTLLLADGAIHASRTLHSRLLSNILRAPMLFFDTTPSGRVVNRFAKDMFTVDELIPTALRSVILKLLELLATLVLICLAVPLFTAVVVPLIIIYHFVERFYLTTSRQLRRLDSVSRSPIYSLFGETVSGLSVIRAFGHQERFLQQNRTTIDNNLKCVCQLIVSNRWMAIRLELLGNLVVFFSALFAVISRDSLDSGLVGLSISYALNVTLTLNALVRMTSQLETHVVSVERVKEYAEIPNEAAWTSERRPAEDWPSEGTIWFQDYKVRYRPQLDLVLHGITCHIHSKEKIGIVGRTGAGKSSLTNCLFRIIEAADGRILIDGENIASMGLHDLRSRLTIIPQDPVLFSGSLRMNLDPFEKFSDEDIWKVLDLAHLKEYVNSLEAGLQHEIAEGGENLSVGQRQLLCLARALLRKSKILILDEATAAVDLETDDLIQTTIRREFSHCTVLTIAHRINTILDSSRVMVLDAGRIVEFGPPDVLL-QKRGHFYALAKDAGICKTE 1558
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: abcc3 (ATP-binding cassette, sub-family C (CFTR/MRP), member 3 [Source:ZFIN;Acc:ZDB-GENE-050517-16]) HSP 1 Score: 748.814 bits (1932), Expect = 0.000e+0 Identity = 464/1355 (34.24%), Postives = 746/1355 (55.06%), Query Frame = 3
Query: 594 PNLRETKHPEIIASIFSQLTYKWMDSFIYNWYK--VDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSE----DEEFLINSEEKESFILEHSGKV------LIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVD---MEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPG----ASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL----------NESSDKVDKNQNNLIQPSAPN-------------------KRKRSRLSTSGSQGFDGN--------ENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGV--LQAFG-NVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWL-CLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNN-YISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
PNL PE+ AS S+LT+ W N Y+ + M+D S H S + + A + E+ I +R++ S+ + L +E+ +S G LI+++ A L+ + ++++DIL PL+L L+ + + + TW G A + + + S+ + F IR+R ++ G++ RK L ++ A+ + + G++ + VD M I N + + W S P I L + L+ LG S+ GVA+++ +IP I + + + +D+R+ L+E L+G+++IKMY WE F + I +R+ EL + + + PFLV ++F Y+ ++ AE+ F+++ LFN ++ P+ LP +++ A VS R+ FL E+ P + SP + + I+ G F+W+ P+L +I L V + L+AVVG VG GKSSL++A+LGE+ L G+V +G++AYV Q+AWIQN +LR+N+L + ++ +Y +VL AC LE D+ +LP D TEIGE+G+NLSGGQ+QRVSLARA+Y + ++LLDD LSAVD +VG+ +F ++I GLL +TRVLVTHGL +LP VD I V+ G++SE G+Y LM G F L +S D + +I +P + +R + GSQ G+ E + + + E + +G + L+ ++ Y +A G + S LA ++F G NVWL A N ++ + + + Y +G Q + ++ G LRA+ +H LLD L S + F++ TP GRI+NRF+KD+F+ID L + I ++++I I TP F + IP+++ Y +Q FY+++SRQ +RL+S S V +H E+ +G++ +R+ E F R +D + +S R + + L+ LG +V + +FAVL+R SL A VGLS+SYA+QVT +++W+ R +E E+N V++ER+++Y+ P E+ E + +W S G++ ++S +Y L VL+NI+ +I GGEK+G+VGRTGAGKSSL L L R+VE SG I IDGV+I+ IGLH LR ++TI+PQDPV+F G+L+ NLDPF ++D ++ ++LE + + + +L G+ ++C G N S+GQ+QL CLAR LL+++++++LDEATA+VD ETD + I+ F + TV+ IAHRL T++DC +++ L G I+EF SP LLS F +A+
Sbjct: 186 PNL----CPEVGASFISRLTFCWFTRMAVNGYRRGLKMSDLWSLR-HKDSCSFVVPHLQAVW---RKEQARIAQRSAVSQSTPAETRKLHTTEKSQSGGAGTEGGATGQEPSLIRAMALAFGPRYLVGSVYKLLQDILSFASPLLLSHLIRFVGDNSRP-TWHGYALAGLMFLCAIATSMLAHQHFHAGFVTGIRLRSALTGLLYRKALMITQAARLSCAGGELTTLMSVDVQHMADITNNLNFVW---SAPLHICLAMYFLWQHLGPSVLAGVAVMLLLIPFNAFIALNIRTLQAQIIKKRDERVRTLSEALSGVRIIKMYAWEGRFRDVILRVREHELAVLGRAAYFSMLSAFTWLCSPFLVALASFGVYVLVDEHHVLDAERAFVSLALFNLLRYPLNQLPQLMSELAMASVSLRRLRNFLSLEELDPHA------VDRSPSHLRESCVSIEGGTFTWSWDEPPILHDISLAVPRGCLLAVVGTVGSGKSSLMAALLGELNKLGGSVAVKGQVAYVAQQAWIQN-SLRDNVLFGRPLDETWYREVLQACALEQDLLALPAGDNTEIGEKGINLSGGQRQRVSLARAIYSKASVFLLDDPLSAVDAHVGKHIFERVIGPSGLLAGQTRVLVTHGLSFLPHVDRIVVLT-AGRVSESGSYSELMLSGEAFSELLRIHGQGDGAGEDSPASQDDGPHVIIDLRSPGPDEVLSTCSNIADMEPVMTEPRRMLMRQLGSQEASGSGTTQGVSTETRGHKETQPGSTLMQPESMETGHMKLSVVLHYLRAVGAPL---STLALLLFCANYTTMLGTNVWLSEWA------GEPVVNGTQRNTGYRLGVYSALGAVQSVLSLVMVLMVFKGCLRAAGSLHLALLDNKLHSPISFYDVTPLGRIINRFSKDVFMIDEVLPPTFLMFLGALCNSIFTILIIVISTPVFVVAAIPLVVIYFFVQRFYVATSRQLKRLESTVRSPVFSHFGESVAGAATLRAFRQEERFVIAGDRAVDALQRTSYPSIVSQRRVGAVWLEFLGACVVLFAAMFAVLSRDSLKAGTVGLSVSYAMQVTVVMSWMVRMSSEVESNIVAVERVKEYSETPPEADWEVESCRPPADWPSQGHVEFRDYSTRYREGLDLVLRNISCDIKGGEKVGIVGRTGAGKSSLTLCLLRMVEAASGAIAIDGVDISRIGLHDLRSRITIIPQDPVLFGGSLRDNLDPFGHHSDAEVWEALEFAHLGETARALPGGIQHECAEGGENFSVGQRQLACLARALLRRTRVLVLDEATAAVDVETDALIQGTIRTHFHACTVLTIAHRLHTVLDCTRVMVLSSGQIVEFDSPDVLLSRKDSAFHKMAR 1511
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: ABCC8 (ATP binding cassette subfamily C member 8 [Source:HGNC Symbol;Acc:HGNC:59]) HSP 1 Score: 545.428 bits (1404), Expect = 3.294e-167 Identity = 367/1206 (30.43%), Postives = 628/1206 (52.07%), Query Frame = 3
Query: 1137 IRVRGSVIGMISRKTLRLSAEA--KATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFV-PFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEI-----------YPRSSVPLVVTQM------------------------------SPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTV--------------------------QTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTR--VLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDK--NQNNLIQPSAPNKRKRSRLSTSGSQ-----GFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYI-------NCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRF--SLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETN--NYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADE 4484
I+ R +V MI K L LS + + ++ I N+ VD Q+M ++ L + P QII+ V LLY LG S +G A+I + P++ I + + L R+ +E+++GIK++K+Y WE+ F + +E R +EL++ ++I + M +P + +TF Y++ P +S F ++ LF+ + P+ LL V + A++S ++ +FL ++EI P+ S V QM S +I++ G F+W +L +I + + +L VVG++G GKSSLLSA LGEM+ ++G+V + G +AY Q+ WI N+ ++ NI FN+ Y V++ C L+ DI+ LP D+T+IGE+G+NLS GQ+QR+S+ARA+YQ +++ LDD +A+D+++ L + I GLL + TR VLVTH L++L D I + D G + GT + + E E +K D+ + +I+ +RK R + + F+ EN + ++F+ +SH ++ G + L Y A+G + +L+ + V A + WL M T LN + N + S+ + + + ++ ++ ++ + GL+A++ +H LL ++R+ L+FF+ TP G ILNRF+ DL +ID + + ++ ++ ++++ VI+ VTP F + +P+ + + +Q + +S+ + LD +L H+MET G + IR+ ES F + ID +N L + RWL +R+D +G IV + + ++ F L + LVGL ++YAL V+ LNW+ R A+ E +I+R+ + +E + + + E+W G I + S +Y+ +L LKN++ I G+K+G+ GRTG+GKSSL+LALFR+++ G I ID V+I+ I L LR +L+I+ QDPV+FSG+++ NLDP TD L +LEI+ + V +L G++ G N S+GQ+QL CLAR ++++ I+I+DEATA++D T++ + + + F TV++IAHR+ I+D D ++ L+ G + E SP LL+N F +L ++++
Sbjct: 384 IKFRAAVQTMIYDKILHLSTSSVSRGKMTSRYISNVVTVDSNQLMWFLFLCPNLWALPVQIIVGVSLLYSLLGVSALIGAAVIALLAPLQYCIATKLARAQKLTLEHSSSRIKQTSELVHGIKLLKLYAWEQVFCSTVEETRSKELRSLSTFAIYTALSTFMNAAIPITAVMATFVTYVHLSSPDITLSPAVAFASLALFHILVTPLFLLSTVVRFAVKALISMQKLTEFLATSEIGDEPNTLDVEPRPKKSSNADVVQMMAVNRKQPQKPVWDDFEPPQDWRQFEFTDGSEDFAIKVTGGVFTWASSEPSLLTDINICIPHGQLTMVVGQIGCGKSSLLSATLGEMHLVSGSVYWNSSPRQQSVNTKNNRQERRASTFCRRRGSVAYAAQKPWILNSNVQENITFGSPFNEERYKAVINTCSLQPDIDILPQGDRTQIGEKGINLSAGQRQRISVARALYQHTNVVFLDDPFTALDIHLSDHLMHSGI--LGLLHNDTRTVVLVTHKLQYLTHADWIIAMKD-GTVQREGTLKDIQTSDPELYEMWKELMNKQDEELQKETIIESRTALERKNLRRAMYSKEVLVKTSFEDEENGINS--EHFDSMSH---LLPG-LPLGEWRSYLAASGWPLLLLIVLSQLCKHVSMAAPDFWLAMW--TSRALNVTAQNHNCTSSSVCLCLQSLLASIFAVLCCLAVVMCLISSLAVEWVGLKAARGLHKRLLGRIVRAPLRFFDTTPLGSILNRFSADLHMIDQLIPSSTESLVRSSLFSLSAVSVIAYVTPIFLVALVPLALVHYFIQKHFRIASKDLQELDENTKLPLLLHIMETVDGIATIRAFRHESQFRQRIFELIDANNVPFLFLSAANRWLEVRMDYIGASIVLATAMASITRSFYSGLDSGLVGLGLTYALLVSIYLNWVVRNLADIEVQLQAIKRVNNLMKVEIEDDERSPELHAVPEDWPHRGEIKINRLSARYDASLKPALKNLSSVIQPGQKVGICGRTGSGKSSLSLALFRMLDIFDGSITIDDVDISKIPLSLLRSRLSIILQDPVLFSGSIRFNLDPEARSTDSMLWDALEIAQLKCVVKALPGGLDATVREGGENFSLGQRQLFCLARAFVRQTAILIMDEATAALDMATEKILQKVVMTAFADRTVVMIAHRVANILDADVVLVLNQGLLEENDSPANLLANPDTIFSSLVKSNK 1578
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006454.1 (pep scaffold:Pmarinus_7.0:GL483531:32:7621:1 gene:ENSPMAG00000005809.1 transcript:ENSPMAT00000006454.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 354.369 bits (908), Expect = 8.992e-109 Identity = 185/495 (37.37%), Postives = 301/495 (60.81%), Query Frame = 3
Query: 3024 RASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQY-LSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINE-TNNYISEN-----WVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAG-KSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADE 4484
RAS ++H L VLRS++ F+ TP+GR+LNRF++D+ +D + I +L++ L VI+ V PWF + IP+ + ++++ R+ +RLD+ + S ++H+ + G I + +F +Y+ + +N+ L + ++RWL +RLDI+ ++ + + VL + A+ GL+ISYA+Q+TG + R +E E S+ERI+ Y +E++ E +++ E W +G+++ ++ ++Y LP VLK +T NI E +G+VGRTG+G KSSL + LFRLVE C G I IDGV I IGL LR +L+I+PQ+PV+F GT++ NLDP YTD+++ ++LE + M D + L + + + G N S+G++QL+C+AR +L+ SKI++LDEATA++D ETD + E I+ F T++ IAHRL T++ CD+I+ +D G ++EF SP LL N + F A+ A E
Sbjct: 6 RASSRLHDSLFLKVLRSSMTVFDTTPTGRLLNRFSRDMDEVDVRMPFQAELFIQNVILVLFCLGVIAAVFPWFLLAVIPLCVLFLIINKISRVFIRELKRLDNISHSPFMSHVAASLQGLPTIHAYSKSDEFLH-RYQELLDTNQACLFLFSCAVRWLAVRLDIISVALITTTALMMVLMHGQIPAAYAGLAISYAIQLTGTFQFTIRLASETEARFTSVERIQHY----IEALEEEAPDHVPEKPLAAEWPQHGSVSFQDVEMRYREGLPLVLKRVTANIKPRENVGIVGRTGSGCKSSLGVCLFRLVELCGGSISIDGVPIGDIGLGDLRSRLSIIPQEPVLFIGTIRTNLDPLGLYTDEQIWEALERTHMKDNIGQLPQKLETEVVENGENFSVGERQLLCVARAILRHSKILLLDEATAAIDTETDTLIQETIRRAFGDCTMLTIAHRLNTVLSCDRIMVMDQGQVVEFDSPSTLLENRASRFAAMMVAGE 495 HSP 2 Score: 66.6254 bits (161), Expect = 2.683e-11 Identity = 112/478 (23.43%), Postives = 199/478 (41.63%), Query Frame = 3
Query: 1176 KTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQ---IILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTK--KYSEKELMWKD-----KRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYF---VPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWT------RIGNP-VLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTL-NGTVQTEG-------------KIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISE 2507
K LR S T G ++N DM+++ + PFQ I V+L+ + LG V ++ VIP+ + + + K + +EL D M+ + L G+ I Y F ++ + + +S L V D++ ++ +T + +P + + + AI L Q + L ++T S RI ++ + E VP P A+ Q+G S+ R G P VLK + ++ ++ + +VGR G G S L L + L G++ +G +++ +PQE + T+R N+ + + L+ ++ +I LP + +TE+ E G N S G++Q + +ARA+ + S I LLD+ +A+D +L + I T + + H L + D I V+ DQGQ+ E
Sbjct: 18 KVLRSSMTVFDTTPTGRLLNRFSRDMDEVD---------VRMPFQAELFIQNVILVLFCLGVIAAVFPWFLLAVIPLCVLFLIINKISRVFIRELKRLDNISHSPFMSHVAASLQGLPTIHAYSKSDEFLHRYQELLDTNQACLFLFSCAVRWLAVRLDIISVALITTTALMMVLMHGQIP-AAYAGLAISYAIQLTGTFQFTIRL----ASETEARFTSVERIQHYIEALEEEAPDHVP-----EKPLAAEWPQHGSVSFQDVEMRYREGLPLVLKRVTANIKPRENVGIVGRTGSGCKSSLGVCLFRLVELCGGSISIDGVPIGDIGLGDLRSRLSIIPQEPVLFIGTIRTNLDPLGLYTDEQIWEALERTHMKDNIGQLPQKLETEVVENGENFSVGERQLLCVARAILRHSKILLLDEATAAIDTET-DTLIQETIRRA--FGDCTMLTIAHRLNTVLSCDRIMVM-DQGQVVE 472
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007076.1 (pep scaffold:Pmarinus_7.0:GL480539:10051:22495:1 gene:ENSPMAG00000006379.1 transcript:ENSPMAT00000007076.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 346.665 bits (888), Expect = 1.618e-105 Identity = 193/523 (36.90%), Postives = 305/523 (58.32%), Query Frame = 3
Query: 2892 LLNNSTFNQSRNSA---KFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRF--SLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSN 4445
LL + + S N + +FY++ YG + G + +L F +GG+ A+K IH LL VL++ + FF+ATP+GRI+NRF+ DLF +D +L + + + L+ ++VV+ PW +V +P+ Y +Q +Y +SR+ +RL S S + +H E+ SG +II++ A F ++ + + + + WL +RL ++G +IV AVL + LVGL+I+YAL + G L+ L + ET VS+ER+++Y I E + ++S +W G + + L Y LP L I+ IN EK+G+VGRTG+GKS+L LFR+V+ G I+ID +I+ + L QLR L I+PQDP +FS T++ NLDP Y D +L + LE + +V G+ + G + S GQ+QL+CLAR +L K+KI+ +DEATASVD++TD + + I+ +FV+STV+ IAHR TI+D D+++ L G ++EF SP +LL +
Sbjct: 2 LLLSPPYRSSANGSDPVQFYLSVYGALAAGNTVFTLLRAFLFAYGGVCAAKNIHVTLLHKVLQAPVSFFDATPTGRIMNRFSSDLFTVDDSLPFIMNIFMAQLFGLVGAIVVMCYGLPWMALVLLPLAGVYYCVQKYYRFTSRELKRLGSVTLSPIYSHFAESLSGLAIIKAFRATDRFTRENEARLELNQRCQFAAVAVMHWLDVRLQMMGVVIVVSLAALAVLEHHLRGVDPGLVGLAIAYALGINGRLSGLVSSFTQTETQMVSVERVQEYRGIASEEAHRHPTHVSPDWPQGGALTFDKVFLTYRPGLPFALNGISFCINSWEKVGIVGRTGSGKSTLFSVLFRIVDVQHGAIYIDNQDISKLALKQLRSNLAIIPQDPFLFSDTVRNNLDPKGSYQDHELWEVLEKCHLKSFVLD-QGGLQAEVAERGRDFSCGQRQLLCLARAMLFKAKILCIDEATASVDQDTDVLLQKTIRSEFVNSTVLTIAHRPNTILDSDRVLVLQGGRVLEFASPHDLLQD 523 HSP 2 Score: 64.6994 bits (156), Expect = 1.075e-10 Identity = 58/198 (29.29%), Postives = 92/198 (46.46%), Query Frame = 3
Query: 1770 TQTITAVVSFGRIGKF--LLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNP-VLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAIL-------GEMYTLNGTV------QTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLE---YDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAV 2306
TQT T +VS R+ ++ + S E + P V+ P + F R G P L I + + + +VGR G GKS+L S + G +Y N + Q +A +PQ+ ++ ++T+RNN+ S+ +VL+ C L+ D L Q E+ ERG + S GQ+Q + LARA+
Sbjct: 260 TQTETQMVSVERVQEYRGIASEEAHRH---PTHVSPDWPQGGALTFDKVFLTYRPGLPFALNGISFCINSWEKVGIVGRTGSGKSTLFSVLFRIVDVQHGAIYIDNQDISKLALKQLRSNLAIIPQDPFLFSDTVRNNLDPKGSYQDHELWEVLEKCHLKSFVLDQGGL----QAEVAERGRDFSCGQRQLLCLARAM 450
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001536.1 (pep scaffold:Pmarinus_7.0:GL479104:2125:31869:1 gene:ENSPMAG00000001392.1 transcript:ENSPMAT00000001536.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 323.939 bits (829), Expect = 8.212e-98 Identity = 172/491 (35.03%), Postives = 292/491 (59.47%), Query Frame = 3
Query: 3024 RASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRF--SLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINE--TNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADE 4484
+ ++ +H+ +L ++ + +++F+ TP G ILNRF+ D I+D + + ++ +L +++L +I+ VTP F I +P+ I Y +Q ++ +SR + LD + +H ET G + IR+ E F D +N L + RWL +RLD +G IV + + ++ + + +LS++ VGL ++YAL V+ LNW+ R A+ E +I+R+ I ES + + + +NW +G I +E S++Y+ L VLK++ +I +K+G+ GRTG+GKSSL+LA FR+V+ GRI ID ++I I LH LR +L+I+ QDP++FSG+++ NLDP D L ++L+I+ + V +L G++ G N S+GQ+QL CLAR ++K+ I I+DEATAS+D T+ + + + F + TV+IIAHR+ TI+ D ++ L GS++E+ +P LL++ S F + +AD+
Sbjct: 30 KTARNVHNNMLKRIVLAPMRYFDTTPLGHILNRFSADTNIMDQQIPTTLESLMRSALLCLSALGIIAYVTPIFLIALVPLAIAYYFIQKYFRVASRDLQELDDSTQLPLFSHFSETVEGITTIRAFRHEVRFRQRLLELTDANNISYLFLSAANRWLEVRLDYIGACIVLIASVASITDSWNNTLSSARVGLCLTYALMVSNYLNWVVRNLADIEVQMGAIKRVNNLLQIETESYDGLLSQAQVPDNWPQSGEIKIEELSVRYDSTLKPVLKHVNAHIQPSQKVGICGRTGSGKSSLSLAFFRMVDTFEGRIIIDNIDIAKIPLHTLRSRLSIILQDPILFSGSIRFNLDPEAACGDGVLWEALDIAQLKHVVKALPGGLDAMVTENGENFSVGQRQLFCLARAFVRKTSIFIMDEATASIDMATESILQKVVMTAFANRTVVIIAHRVHTILTADLVMVLKRGSVLEYDTPSTLLAHDS-MFASFVRADK 519 HSP 2 Score: 61.6178 bits (148), Expect = 1.076e-9 Identity = 56/237 (23.63%), Postives = 112/237 (47.26%), Query Frame = 3
Query: 1890 IEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEG-KIAYVP------------QEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL 2561
I+I+ + PVLK++ ++ + + + GR G GKSSL A + T G + + IA +P Q+ + + ++R N+ + + LD L++ +++LP + E G N S GQ+Q LARA + + I+++D+ +++D+ +S+ K++ ++T V++ H + + D + V+ +G + E T L+ + F SF+
Sbjct: 283 IKIEELSVRYDSTLKPVLKHVNAHIQPSQKVGICGRTGSGKSSLSLAFFRMVDTFEGRIIIDNIDIAKIPLHTLRSRLSIILQDPILFSGSIRFNLDPEAACGDGVLWEALDIAQLKHVVKALPGGLDAMVTENGENFSVGQRQLFCLARAFVRKTSIFIMDEATASIDM-ATESILQKVVMTA--FANRTVVIIAHRVHTILTADLVMVLK-RGSVLEYDTPSTLLAHDSMFASFV 515
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: YCF1 (Vacuolar glutathione S-conjugate transporter; ABC-C transporter of the ATP-binding cassette family; required for vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; role in detoxifying metals (Cd, Hg, As); transports GSSG that is not immediately reduced in cytosol to vacuole; transports unconjugated bilirubin, selenodigluthatione, oxidized glutathione; similar to human cystic fibrosis protein CFTR [Source:SGD;Acc:S000002542]) HSP 1 Score: 717.998 bits (1852), Expect = 0.000e+0 Identity = 466/1338 (34.83%), Postives = 729/1338 (54.48%), Query Frame = 3
Query: 603 RETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHII------LIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLI-GSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQ-EELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEI-QNGRFSWTRIGNP----VLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEH------------LMDFGTEFKSFLNESSDKVDKNQNNLIQP------------------SAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXX-XXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAV--LNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES--INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLT-EGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKAL 4469
R +P A+IFS++T+ WM + Y+ + + DL+ ++ + E+S + N+ E+ ++ S N + K+L+ + F A ++ L+ L++ V D L QK +G L AF + G SV Y + N + ++ ++ +I +K+L LS EA S GDI+N+ VD++++ + + ++ S PFQII+ + LY LGNS++VGV ++V ++P+ +MR+ KK + ++ +KD+R +++EILN IK +K+Y WEK + K+E +R +ELKN + + F++VPFLV TF ++Y ++ + VF A+ LFN + P++++P + I A VS GR+ F + E+ P S L + +I I + F W R P LKNI +K L +VG+VG GK++LLS +LG+++ + G G +AYV Q WI N T++ NIL ++ FY K + AC L D+ L + D+T +GE+G++LSGGQK R+SLARAVY +D YLLDD L+AVD +V + L ++ GLL KT+VL T+ + L D I ++ D G+I+++GTY+ L ++G + NE D + + P S +R+ +T GS F +EN I+ E G+V N + Y KA IL VI L GNVWL ++ NS + + N+A+ Y+ Y +G+G LA ++ +F + ASK +H+++ ++VLR+ + FF TP GRILNRF+ D++ +D L + V + ++ VI T F + IP+ + YI Q +Y+ +SR+ RRLDS S + +H ET G + +R + F I ID + + RWL RL+++G++I+ G+ +V L + +L+A +VGLS+SYALQ+T LNW+ R E ETN VS+ERI++Y + E+ I E + E W S G+I N+S +Y L VLK+I I+I EK+G+VGRTGAGKSSL LALFR++E G I ID + IN IGL+ LR +L+I+PQD +F GT++ N+DP ++YTD+ + ++LE+S + + V S++ +G++ G NLS+GQ+QL+CLAR +L SKI++LDEATA+VD ETD+ V E I+ F T++ IAHRL TI+D D+II LD+G + EF SP +LLS++ F +L
Sbjct: 206 RRKPNPYDSANIFSRITFSWMSGLMKTGYEKYLVEA---DLYKLPRNFSSEELSQKLEKNW---ENELKQKS---------NPSLSWAICRTFGSKMLLAAFFKAIHDVLAFTQPQLLRILIKFVTDYNSERQDDHSSLQGFENNHPQKLPIVRGFLIAFAMFLVGFTQTSVLHQYFLNVFNT-GMYIKSALTALIYQKSLVLSNEASGLSSTGDIVNLMSVDVQKLQDLTQWLNLIWSGPFQIIICLYSLYKLLGNSMWVGVIILVIMMPLNSFLMRIQKKLQKSQMKYKDERTRVISEILNNIKSLKLYAWEKPYREKLEEVRNNKELKNLTKLGCYMAVTSFQFNIVPFLVSCCTFAVFVY-TEDRALTTDLVFPALTLFNLLSFPLMIIPMVLNSFIEASVSIGRLFTFFTNEELQPDSVQRLPKVKNIGDVAINIGDDATFLWQR--KPEYKVALKNINFQAKKGNLTCIVGKVGSGKTALLSCMLGDLFRVKGFATVHGSVAYVSQVPWIMNGTVKENILFGHRYDAEFYEKTIKACALTIDLAILMDGDKTLVGEKGISLSGGQKARLSLARAVYARADTYLLDDPLAAVDEHVARHLIEHVLGPNGLLHTKTKVLATNKVSALSIADSIALL-DNGEITQQGTYDEITKDADSPLWKLLNNYGKKNNGKSNEFGDSSESSVRESSIPVEGELEQLQKLNDLDFGNSDAISLRRASDATLGSIDFGDDEN-----------IAKREHREQGKVKWNIYLEYAKACNPKSVCVFILFIVISMFLSVMGNVWLKHWSEV-----NSRYGSNPNAAR-YLAIYFALGIGSALATLIQTIVLWVFCTIHASKYLHNLMTNSVLRAPMTFFETTPIGRILNRFSNDIYKVDALLGRTFSQFFVNAVKVTFTITVICATTWQFIFIIIPLSVFYIYYQQYYLRTSRELRRLDSITRSPIYSHFQETLGGLATVRGYSQQKRFSHINQCRIDNNMSAFYPSINANRWLAYRLELIGSIIILGAATLSVFRLKQGTLTAGMVGLSLSYALQITQTLNWIVRMTVEVETNIVSVERIKEYADLKSEAPLIVEGHRPPKE-WPSQGDIKFNNYSTRYRPELDLVLKHINIHIKPNEKVGIVGRTGAGKSSLTLALFRMIEASEGNIVIDNIAINEIGLYDLRHKLSIIPQDSQVFEGTVRENIDPINQYTDEAIWRALELSHLKEHVLSMSNDGLDAQLTEGGGNLSVGQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRTAFKDRTILTIAHRLNTIMDSDRIIVLDNGKVAEFDSPGQLLSDNKSLFYSL 1505
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: BPT1 (ABC type transmembrane transporter of MRP/CFTR family; found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p [Source:SGD;Acc:S000003938]) HSP 1 Score: 595.504 bits (1534), Expect = 0.000e+0 Identity = 415/1246 (33.31%), Postives = 659/1246 (52.89%), Query Frame = 3
Query: 1047 GVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQE-ELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGA------SIEIQNGRFSWTR--------------------IGNP--VLKNI-QLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQT--------EGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNK-LISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFG---TEFKSFLNESSDKVDKNQNNLIQPSAPNKR--------------------------------KRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQL-LAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLN---RFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVE--SINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLT------EGMNYDCGNM-----------GTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIK 4493
GV A + ++ N + + + +RGS+ ++ +K+LRL+ + S GDI+N+ VD+ +I + + ++ P QII+ + LY+ LG ++ G+ + ++P+ + R KK S+ ++ +KD R+ +TE+LN IK IK+Y WE+ ++ +R + ELKNFR I ++ ++ VP +V STF + F S +S VF ++ LFN + + +P + I VS R+ FLLS+EI + ++ P A +IE+ N F W IG+ LKNI ++ L+ VVGRVG GKS+ L AILG++ ++G+ + +AY QE+WI N ++R NIL F++ +Y + AC L D++ LP+ D+T +GE+G++LSGGQK R+SLARAVY +DIYLLDD+LSAVD V +++ LI LLK+KT +L T+ + L I + + G+I E+G YE +M+ ++ K L E +D + +Q ++ +R+ L+T + F G A+ + K + + E+ GRV + Y KA G+ L ++ V N WL +++ N S ++ Y +IG+ + ++ +R SKK+H + +V+RS + FF TP GRI+NRF+ D+ +D L + + + +++++ PWF + + +++ YI Q FYI SR+ +RL S + S +++ + E+ +G SII + + F + Y I + F + RWL +RL +G IV + I A+ + LS+ +VGL +SY+L+VTG L W+ R ETN VS+ERI +Y +P E SIN ENW S G I +N+S +Y NL VL NI + I EK+G+VGRTGAGKS+L+LALFR++E G+I IDG++I+ IGL LR L I+PQD F GT+K NLDPF+ Y++D+L +++E + + + + + N + GN+ G+NLS+GQ+QL+CLAR LL +SKI++LDEATASVD ETD+ + + I+ +F T++ IAHR+ T++D DKII LD GS+ EF SP +LLS+ + F +L + Y+K
Sbjct: 333 GVFIALTLFVISVVSVFLTNQFYIGIFEAGLGIRGSLASLVYQKSLRLTLAERNEKSTGDILNLMSVDVLRIQRFFENAQTIIGAPIQIIVVLTSLYWLLGKAVIGGLVTMAIMMPINAFLSRKVKKLSKTQMKYKDMRIKTITELLNAIKSIKLYAWEEPMMARLNHVRNDMELKNFRKIGIVSNLIYFAWNCVPLMVTCSTFGLFSLFSD-SPLSPAIVFPSLSLFNILNSAIYSVPSMINTIIETSVSMERLKSFLLSDEIDDS-----FIERIDPSADERALPAIEMNNITFLWKSKEVLTSSQSGDNLRTDEESIIGSSQIALKNIDHFEAKRGDLVCVVGRVGAGKSTFLKAILGQLPCMSGSRDSIPPKLIIRSSSVAYCSQESWIMNASVRENILFGHKFDQDYYDLTIKACQLLPDLKILPDGDETLVGEKGISLSGGQKARLSLARAVYSRADIYLLDDILSAVDAEVSKNIIEYVLIGKTALLKNKTIILTTNTVSILKHSQMIYAL-ENGEIVEQGNYEDVMNRKNNTSKLKKLLEEFDSPIDNGNESDVQTEHRSESEVDEPLQLKVTESETEDEVVTESELELIKANSRRASLATLRPRPFVG---AQLDSVKKTAQKAEKTEV--GRVKTKIYLAYIKACGVLGVVLFFLFMILTRVFDLAENFWLKYWSESNEK------NGSNERVWMFVGVYSLIGVASAAFNNLRSIMMLLYCSIRGSKKLHESMAKSVIRSPMTFFETTPVGRIINRFSSDMDAVDSNLQYIFSFFFKSILTYLVTVILVGYNMPWFLVFNMFLVVIYIYYQTFYIVLSRELKRLISISYSPIMSLMSESLNGYSIIDAYDHFERFIYLNYEKIQYNVDFVFNFRSTNRWLSVRLQTIGATIVLATAILALATMNTKRQLSSGMVGLLMSYSLEVTGSLTWIVRTTVTIETNIVSVERIVEYCELPPEAQSINPEKR-PDENWPSKGGIEFKNYSTKYRENLDPVLNNINVKIEPCEKVGIVGRTGAGKSTLSLALFRILEPTEGKIIIDGIDISDIGLFDLRSHLAIIPQDAQAFEGTVKTNLDPFNRYSEDELKRAVEQAHLKPHLEKMLHSKPRGDDSNEEDGNVNDILDVKINENGSNLSVGQRQLLCLARALLNRSKILVLDEATASVDMETDKIIQDTIRREFKDRTILTIAHRIDTVLDSDKIIVLDQGSVREFDSPSKLLSDKTSIFYSLCEKGGYLK 1559
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: YBT1 (Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication [Source:SGD;Acc:S000003971]) HSP 1 Score: 588.186 bits (1515), Expect = 0.000e+0 Identity = 418/1399 (29.88%), Postives = 681/1399 (48.68%), Query Frame = 3
Query: 609 TKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLR-----------------------LSAEAKATYSA--GDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPV-LKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTV----------------QTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFND-------------ISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVW---------------------LGMLADTQSLLNN----------STFNQ--SRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNM----------------------GTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
T PE + SI + + W+DSF++ +KV + K + L + S + + + +R+ IF +L+ + G+ I L RI+ + N W Y V + ++ ++ + ++ IR++ +I I K LR ++ + ++T SA G IIN+ +D ++ Y L ++ + LLY LG + VGV +IV ++P+ + + +K L D R+ L E I++IK + WE++F I +IR+ EL SI W I + ++ + P +V ++F +YIY V +++ F A+ LF ++ P+ L ++ + + VS R+ FL N+ + T G +N SW + LK++ + + KL V+G G GK+SLL A+LGEMY LNG V T IAY Q AW+ N+T++NNIL FN+ Y V++AC L+ D E L D TEIGE+G+ LSGGQKQRVSLARA+Y ++ LLDD LSAVD + +++ I+ L++ +T +LV+H + E+ V+ + G++ ++G ++ G + L +SS + N+ +A + S L Q N N+ K + EE G V L+ WY K G + S + + + L G W + ++ S L + S NQ S +S +Y+ Y IIG Q L G+ AS+KI +++L+ VL S ++FF+ATP+GRI+NRF+KD+ ID L I + ++++++I+ +TP F V I + I Y + FY++ SR+ +R +S + S + H ET G + IR+ E F ID++NK +++ RWL R+D++G+L++FG+ +F + N +L + + G+S++YA+ T WL R +E E N S+ER+++Y I E NE W +G I + + SL+Y NLP V+KN++ +++ KIG+VGRTGAGKS++ ALFR +E +G I ID ++I+ + L +LRR +TI+PQDP +FSGT+K NLDP+DE++D ++ ++L+ ++ L +G + N G+NLS GQ+QL+CLAR+LL+ KII+LDEATAS+D +D ++ E I+ +F ST++ IAHRL+++ID DKI+ +D G + E+ P LL N F ++ +
Sbjct: 277 TPSPEPVTSIAGFICWAWLDSFVWKAHKVSIKVKDIWGLMMQDYSFFVVKKFRYFVDHKVKRKRIFSLNLFFFFSNYLVLQ--------------CFWAFLGSVLSFIPTVLLKRILEYVEDQ-------------SSAPSNLAW---FYVTVMFVGRILVAICQAQALFFGRRVCIRMKSIIISEIYTKALRRKISTNKTKPSNEDPQEINDQKSINGDEESTSSANLGAIINLMAIDAFKVSEICGYLHSFLEAFVMTVVALALLYRLLGFAAIVGVLIIVAMLPLNYKLAKYIGDLQKKNLAVTDNRIQKLNEAFQAIRIIKYFSWEENFEKDINTIRENELSLLLMRSIVWSISSFLWFVTPTIVTAASFAYYIY-VQGEVLTTPVAFTALSLFTLLRDPLDRLSDMLSFVVQSKVSLDRVQDFLNENDTKKYDQL----TIDPNGNRFAFENSTISWDKDNQDFKLKDLNIEFKTGKLNVVIGPTGSGKTSLLMALLGEMYLLNGKVVVPALEPRQELIVDANGTTNSIAYCSQAAWLLNDTVKNNILFNSPFNEARYKAVVEACGLKRDFEILKAGDLTEIGEKGITLSGGQKQRVSLARALYSNARHVLLDDCLSAVDSHTASWIYDNCITGP-LMEDRTCILVSHNIALTLRNAELVVLLEDGRVKDQGDPIDMLQKGLFGEDELVKSS--ILSRANSSANLAAKSSTSLSNLPAVKEQQVSVNNNSSHFEAKKLQKSLRTEAERTEDGKLIKEETKEEGVVGLDVYKWYLKIFGGWKIVSFLASLFLIAQLLYIGQSWWVRAWASHNVIAKIIPRAQRAIAFISKKASHLIDWRGSSQISMASAENQPSSGHSTMYYLVLYLIIGFAQALLGAGKTILNFVAGINASRKIFNMILNKVLHSKIRFFDATPTGRIMNRFSKDIEAIDQELTPYIQGAFYSLIECLSTVILITFITPQFLSVAIVVSILYYFVGYFYMAGSRELKRFESISRSPIYQHFSETLVGVTTIRAFGDEGRFMQENLHKIDENNKPFFYLWVANRWLAFRIDMIGSLVIFGAGLFILFNINNLDSGMAGISLTYAISFTEGALWLVRLYSEVEMNMNSVERVKEYMEIEQEPYNEHKEIPPPQWPQDGKIEVNDLSLRYAPNLPRVIKNVSFSVDAQSKIGIVGRTGAGKSTIITALFRFLEPETGHIKIDNIDISGVDLQRLRRSITIIPQDPTLFSGTIKTNLDPYDEFSDRQIFEALKRVNLIS-EEQLQQGATRETSNEASSTNSENVNKFLDLSSEISEGGSNLSQGQRQLMCLARSLLRSPKIILLDEATASIDYSSDAKIQETIRKEFQGSTILTIAHRLRSVIDYDKILVMDAGEVKEYDHPYSLLLNKQSAFYSMCE 1636 HSP 2 Score: 75.8702 bits (185), Expect = 4.929e-14 Identity = 103/479 (21.50%), Postives = 203/479 (42.38%), Query Frame = 3
Query: 3105 GRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRW-----LCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGN-INLENFSLQYNI-NLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINS---IGLHQLRRQLTILPQDPVIFSGTLKRNL---DPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIE-AIKFQFVSS-TVIIIAHRLK-TIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIK 4493
G I+N D F + + + V+ + +L ++ + + IVG+ I++ + L ++ + + + L E + II+ E +FE + N + N+ L+ S+ W L + F I+ + + LS+ L+ L+ L+ + + VS++R++ + + N+T Y NGN EN ++ ++ N LK++ I G+ V+G TG+GK+SL +AL + +G++ + + + + + Q + + T+K N+ PF+E + +E G+ L G + G G LS GQKQ + LAR L ++ ++LD+ ++VD T + + I + T I+++H + T+ + + ++ L+DG + + G P ++L K L DE +K
Sbjct: 476 GAIINLMAIDAFKVSEICGY-LHSFLEAFVMTVVALALLYRLLGFAAIVGVLIIVAMLPLNYKLAKYIGDLQKKNLAVTDNRIQKLNEAFQAIRIIKYFSWEENFE--KDINTIRENELSLLLMRSIVWSISSFLWFVTPTIVTAASFAYYIYVQGEVLTTPVAFTALSLFTLLR--DPLDRLSDMLSFVVQSKVSLDRVQDFL-----NENDTKKYDQLTIDPNGNRFAFENSTISWDKDNQDFKLKDLNIEFKTGKLNVVIGPTGSGKTSLLMALLGEMYLLNGKVVVPALEPRQELIVDANGTTNSIAYCSQAAWLLNDTVKNNILFNSPFNE---ARYKAVVEACGLKRDFEILKAGDLTEIGEKGITLSGGQKQRVSLARALYSNARHVLLDDCLSAVDSHTASWIYDNCITGPLMEDRTCILVSHNIALTLRNAELVVLLEDGRVKDQGDPIDMLQ------KGLFGEDELVK 935
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: VMR1 (Vacuolar membrane protein; involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; VMR1 has a paralog, YBT1, that arose from the whole genome duplication [Source:SGD;Acc:S000001027]) HSP 1 Score: 568.54 bits (1464), Expect = 1.053e-175 Identity = 385/1193 (32.27%), Postives = 638/1193 (53.48%), Query Frame = 3
Query: 1119 LTNKISIRVRGSVIGMISRKTLR--LSAEAKATYSA-------GDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGAS-IEIQNGRFSWTRIGNPV----LKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTV-------------QTEG---KIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLS-TSGSQGFDGNENAEENYEKYFND--ISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWL---------------GMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISEN-----------WVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSL------------EISGMLDWVNSLTE---GMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
+++KI +R+R +IG I K LR L K + + G IIN+ +D ++ Y ++ + II+ V LL+ LG S F G+++I+ + P+ + L K+ ++ L D+R++ L E L I+++K + WE++ N+I+SIRQ+EL++ S+ W + + ++ + P LV TF FV ++A F + LF ++ P+ L ++ + VS RI FL ++ + + + SP + IE +N +W + + L + + + KL ++G G GKS+LL +LGE+ ++G++ EG AY Q AW+ N+T++NNI+ +N+ Y KV+DAC L+ D+E LP D TEIGE+G+ LSGGQKQR+SLARAVY + LLDD LSAVD + ++ I+ L+K++T +LVTH + ++ + G++ +GT L G FK + S + N+ N + AP K ++ + + FD N + ND + EEE +G +S + WY K G F +++ A I + W G DT L + ++++++A +Y+ Y +IG+ Q + G+RAS+KI + LLD VL + ++FF+ TP GRI+NRF+KD+ +D L + I + + + +I+++TP F V + + + Y + +Y+++SR+ +RLDS S + H ET G IR+ E F ID++N+ ++++W R+D++G IV S F +LN ++ + L G+S++YA+ T WL R + FE N S+ER+++Y+ I E NY+ + W +G I +EN SL+Y NLP V++N++ ++ KIG+VGRTGAGKS++ ALFRL+E +G I IDG +I+ I L LRR +TI+PQDP++F+GT+K N+DP+DEY + K+ K+L E+ + NS ++ + G NLS G++QL+ +AR+LL++ KII+LDEAT+S+D ++D + I+ +F ST++ IAHRL+++ID D+II +D G + E+ P ELL + G F ++ +
Sbjct: 403 VSDKICLRIRAILIGEIYAKGLRRRLFTSPKTSSDSDSISANLGTIINLISIDSFKVSELANYLYVTVQAVIMIIVVVGLLFNFLGVSAFAGISIILVMFPLNFLLANLLGKFQKQTLKCTDQRISKLNECLQNIRIVKYFAWERNIINEIKSIRQKELRSLLKKSLVWSVTSFLWFVTPTLVTGVTFAI-CTFVQHEDLNAPLAFTTLSLFTLLKTPLDQLSNMLSFINQSKVSLKRISDFLRMDDTEKYNQLTI-----SPDKNKIEFKNATLTWNENDSDMNAFKLCGLNIKFQIGKLNLILGSTGSGKSALLLGLLGELNLISGSIIVPSLEPKHDLIPDCEGLTNSFAYCSQSAWLLNDTVKNNIIFDNFYNEDRYNKVIDACGLKRDLEILPAGDLTEIGEKGITLSGGQKQRISLARAVYSSAKHVLLDDCLSAVDSHTAVWIYENCITGP-LMKNRTCILVTHNVSLTLRNAHFAIVLENGKVKNQGTITELQSKGL-FKEKYVQLSSRDSINEKNANRLKAPRKNDSQKIEPVTENINFDAN---------FVNDGQLIEEEEKSNGAISPDVYKWYLKFFGGFKALTALFALYITAQILFISQSWWIRHWVNDTNVRINAPGFAMDTLPLKGMTDSSKNKHNAFYYLTVYFLIGIIQAMLGGFKTMMTFLSGMRASRKIFNNLLDLVLHAQIRFFDVTPVGRIMNRFSKDIEGVDQELIPYLEVTIFCLIQCASIIFLITVITPRFLTVAVIVFVLYFFVGKWYLTASRELKRLDSITKSPIFQHFSETLVGVCTIRAFGDERRFILENMNKIDQNNRAFFYLSVTVKWFSFRVDMIGAFIVLASGSFILLNIANIDSGLAGISLTYAILFTDGALWLVRLYSTFEMNMNSVERLKEYSSI------EQENYLGHDEGRILLLNEPSWPKDGEIEIENLSLRYAPNLPPVIRNVSFKVDPQSKIGIVGRTGAGKSTIITALFRLLEPITGCIKIDGQDISKIDLVTLRRSITIIPQDPILFAGTIKSNVDPYDEYDEKKIFKALSQVNLISSHEFEEVLNSEERFNSTHNKFLNLHTEIAEGGLNLSQGERQLLFIARSLLREPKIILLDEATSSIDYDSDHLIQGIIRSEFNKSTILTIAHRLRSVIDYDRIIVMDAGEVKEYDRPSELLKDERGIFYSMCR 1572
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: YOR1 (Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter mediates export of many different organic anions including oligomycin; homolog of human cystic fibrosis transmembrane receptor (CFTR) [Source:SGD;Acc:S000003513]) HSP 1 Score: 446.432 bits (1147), Expect = 1.810e-132 Identity = 302/887 (34.05%), Postives = 478/887 (53.89%), Query Frame = 3
Query: 1941 LKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL---NESSDKVDKNQNNLIQPSAPN-------------KRKRSRLSTSGSQG---FDGNENAEENYEKYFNDISHE--EEIMSGRVSLNSIVWYFKAT---GIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRN-SAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQY-TMIPVE-SINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGM-----LDWVNSLTEGMNYDCGNM------------GTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKAL 4469
K++ ++K + I + G +G GKSSLL+A+ G M +G V+ G + WIQN ++R+NI+ FNK Y +V+ C L+ D++ LP D TEIGERG+ LSGGQK R++LAR+VY+ DIYL DD+LSAVD VG+ + ++ ++ G+L +KTR+L TH L + + V+ GQ+ + GT + L + L +++S+K D+ Q ++ K+K + +S + + G DG+ +++E E+ N IS + E + V W F A I V G++ + F +VWL T N+ +N FY+ Y + + + G+ ASK ++ + +L + + + + TP GRILNRFTKD +D+ L ++ + ++ ++ V+ + PWF I +L+ ++L+ Y SS R+ +RL++ SFV +L E G I++ ++ F + I+K N+ + + RW+ + LD++ + V F +SA+ VG+ ++Y LQ+ G+LN + R + E + S ER+ Y T +P+E S + E+W S G I EN Y LP VLKN+ +NI GEKIG+ GRTGAGKS++ AL+RL E +G+I ID V+I+ +GL LRR+L I+PQDPV+F GT+++NLDPF+E TDD+L +L G L V N G M G+N S+G++QL+ L R L+++SKI+ILDEAT+SVD ETD ++ I +F T++ IAHRLKTI++ D+I+ L+ G + EF +P L S F+++
Sbjct: 604 FKDLNFDIKKGEFIMITGPIGTGKSSLLNAMAGSMRKTDGKVEVNGDLLMCGY-PWIQNASVRDNIIFGSPFNKEKYDEVVRVCSLKADLDILPAGDMTEIGERGITLSGGQKARINLARSVYKKKDIYLFDDVLSAVDSRVGKHIMDECLT--GMLANKTRILATHQLSLIERASRVIVLGTDGQV-DIGTVDELKARNQTLINLLQFSSQNSEKEDEEQEAVVAGELGQLKYESEVKELTELKKKATEMSQTANSGKIVADGHTSSKE--ERAVNSISLKIYREYIKAAVG----KWGFIALPLYAILVVGTTFCSL--------FSSVWLSYW----------TENKFKNRPPSFYMGLYSFFVFAAFIFMNGQFTILCAMGIMASKWLNLRAVKRILHTPMSYIDTTPLGRILNRFTKDTDSLDNELTESLRLMTSQFANIVGVCVMCIVYLPWFAIAIPFLLVIFVLIADHYQSSGREIKRLEAVQRSFVYNNLNEVLGGMDTIKAYRSQERFLAKSDFLINKMNEAGYLVVVLQRWVGIFLDMVAIAFALIITLLCVTRAFPISAASVGVLLTYVLQLPGLLNTILRAMTQTENDMNSAERLVTYATELPLEASYRKPEMTPPESWPSMGEIIFENVDFAYRPGLPIVLKNLNLNIKSGEKIGICGRTGAGKSTIMSALYRLNELTAGKILIDNVDISQLGLFDLRRKLAIIPQDPVLFRGTIRKNLDPFNERTDDELWDALVRGGAIAKDDLPEVKLQKPDENGTHGKMHKFHLDQAVEEEGSNFSLGERQLLALTRALVRQSKILILDEATSSVDYETDGKIQTRIVEEFGDCTILCIAHRLKTIVNYDRILVLEKGEVAEFDTPWTLFSQEDSIFRSM 1462 HSP 2 Score: 79.7221 bits (195), Expect = 3.000e-15 Identity = 62/293 (21.16%), Postives = 123/293 (41.98%), Query Frame = 3
Query: 1044 KGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQ-MSPGASIEIQNGRFSW 1919
KG+ YA + + + N+ F + ++ + + +K S A+ + G + + D+ +I + + L P + + +VLL LG VG+ + + + +L + ++ D R+ ++ E+LN IK+IK Y WE ++ I+ IR +E+ R + L M +P + TF +Y V +F ++ LF + L M LP + I ++ GR+ L + E P + + + P ++++ + F W
Sbjct: 248 KGIGYAIGACLMMFVNGLTFNHFFHTSQLTGVQAKSILTKAAMKKMFNASNYARHCFPNGKVTSFVTTDLARIEFALSFQPFLAGFPAILAICIVLLIVNLGPIALVGIGIFFGGFFISLFAFKLILGFRIAANIFTDARVTMMREVLNNIKMIKYYTWEDAYEKNIQDIRTKEISKVRKMQLSRNFLIAMAMSLPSIASLVTF-LAMYKVNKGGRQPGNIFASLSLFQVLSLQMFFLPIAIGTGIDMIIGLGRLQSLLEAPEDDPNQMIEMKPSPGFDPKLALKMTHCSFEW 539 HSP 3 Score: 63.1586 bits (152), Expect = 3.318e-10 Identity = 129/559 (23.08%), Postives = 233/559 (41.68%), Query Frame = 3
Query: 1008 NYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEK--------ELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYS-TFTFYIYFV----PFSIISAEKVFIAIVLFNNIQLPMLL--LPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGAS------IEIQNGRFSWTRIGNP-VLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLN-----------------GTVQTEGKIAYVPQEAWIQNNTLRNNI--LCTKSFNKIFYGKVLDACCLEYDIESL----PNRDQTE-----------IGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGT 2516
N FK + ++ + G+ FVF +F N FT+ + I + ++ L T G I+N D + + N + S L++ F I+ V ++ V + IP + I L + + E + + N L E+L G+ IK Y ++ F K + L N N + G+ ++ + + FL M + F I + F I +A + ++L +QLP LL + +TQT + S R+ + + P +M+P S I +N F++ R G P VLKN+ L ++ + I + GR G GKS+++SA +Y LN G K+A +PQ+ + T+R N+ ++ ++++ V + D+ + P+ + T + E G N S G++Q ++L RA+ + S I +LD+ S+VD + +++ G T + + H LK + D I V+ ++G+++E T
Sbjct: 924 NKFKNRPPSF-YMGLYSFFVF-----AAFIFMNGQFTILCAMGIMASKWLNLRAVKRILHTPMSYIDTTPLGRILNRFTKDTDSLDNELTESLRLMTSQFANIVGVCVM-------CIVYLPWFAIAIPFLLVIFVLIADHYQSSGREIKRLEAVQRSFVYNNLNEVLGGMDTIKAYRSQERFLAK-----SDFLINKMNEA-GYLVVVLQRWVGIFLDMVAIAFALIITLLCVTRAFPISAAS---VGVLLTYVLQLPGLLNTILRAMTQTENDMNSAERLVTYATELPLEASYRKP----EMTPPESWPSMGEIIFENVDFAY-RPGLPIVLKNLNLNIKSGEKIGICGRTGAGKSTIMSA----LYRLNELTAGKILIDNVDISQLGLFDLRRKLAIIPQDPVLFRGTIRKNLDPFNERTDDELWDALVRGGAIAKDDLPEVKLQKPDENGTHGKMHKFHLDQAVEEEGSNFSLGERQLLALTRALVRQSKILILDEATSSVDYETDGKIQTRIVEEFG---DCTILCIAHRLKTIVNYDRILVL-EKGEVAEFDT 1447
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO36474 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SII0]) HSP 1 Score: 821.231 bits (2120), Expect = 0.000e+0 Identity = 470/1184 (39.70%), Postives = 714/1184 (60.30%), Query Frame = 3
Query: 1038 TWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLN------ESSD-------KVDKNQNNLI--------------QPSAPNKRKRSRLS---------TSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES--INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
+W+G +YA + S+ + F + I+++ ++ G+I K LRL++ ++ +AGD++N+ VD +++++ Y +L S P QI++ + LY +G SI GV ++V +IP + + R ++K K++ KD R+ I+ EILNG+KV+K+Y WE+SF K+ IR +EL + +N F PFLV S TF IY + +I++A F+AI LFN ++ P+ +LP + + A VS R+ KFL +E+ + + + +S A I + +G FSW G P L NI L + L+AVVG+VG GKS+LLSA+LGE + G V +G +AYVPQ+AWIQN TLR+N++ ++F+ Y K + C LE D + LP D TEIGERG+NLSGGQKQRV+LARAVY ++D+YLLDD LSAVD +VG+ +F+K+I +G L+ KTRVLVTHG+ +LP VD+I V+ D G++SE GTY+ L+ F FL +S D +V +++ +++ +P R+R R + TS + D EE+ E + + EE+ +G V Y K+ G+F+ IL ++ +WL + +N T + +R+ Y+ Y G Q V++ FG +RAS+ IH LL + + + FF TP GR++NRF+KDL+++D T+ + + + + I +L I+ TP F V IP+ I Y+L+Q Y++SSRQ +R++S + S + + ET SG+S IR+ + F Y +D++ +S RWL LRL+ +GNLI+F + +FAV+ R S+ ++LVG+SI+YALQ+T LN + RQ +E ETN VS+ER ++Y + E+ + E ++ + W G I +E+F L+Y NLP VLKNI+++I GEKIG+VGRTGAGKS+L LALFR++E GRI +D ++I+ +GL LR LTI+PQDPV+FSGTL+ NLDPFD Y+D+ L + LE+S + + + L EG+ + G NLS+GQ+QL+CLAR LL+KSK+++LDEATA+VD ETD + I+ +F TV IAHRL TI+D +I+ LD G ++EF SP+ L++ G F +AQ
Sbjct: 50 SWEGYMYALIMFAAAAFQSILLHAYFHIVISAGIKIKTALTGLIYSKALRLNSVSRNKSTAGDMVNLMSVDAQRVLDMCTYINLLWSGPLQIVVALYFLYDTMGWSIVAGVVVMVLLIPFNLVVTRFSRKLQLKQMANKDSRIRIMNEILNGMKVLKLYAWEESFMAKVTGIRNQELHHLKNAMYLNAFFGFTFTCAPFLV--SLATFAIYVLTGNILTANNAFVAISLFNILRFPLTVLPNVIISYVQAQVSLKRLTKFLTLDELDETNVHKKMPSHISNQA-IHVDDGSFSWDVTGQPTLHNINLNIPDGSLVAVVGQVGCGKSTLLSALLGETEKVTGEVYVKGSVAYVPQQAWIQNATLRDNVIFGRNFDSRRYHKTIKVCALETDFDILPAGDMTEIGERGINLSGGQKQRVNLARAVYFNADVYLLDDPLSAVDSHVGKHIFDKVIGPRGKLRKKTRVLVTHGISFLPQVDQIVVLQD-GRVSEVGTYKELLANRGAFAEFLKTFAPEEKSGDAALKVLREVPEDEEDILVRLQAIGDEDEMFMEPEPQPIRRRGRANSVVTIGTTITSDTADTDCMTIMEEDRE--VDHMIGEEKAATGSVKWVVFWAYAKSIGVFIASIVILFMILSEGALVGSRIWLAAWS-----ADNDTSDATRD---MYLGGYAAFGFFQAFFVLVSSICLAFGSVRASRSIHDSLLIAIFHAPMSFFETTPLGRVVNRFSKDLYVVDDTVPRSTSGFLRTALSAIGTLFAITYATPLFLSVIIPLGIVYVLIQRLYVASSRQLKRIESVSKSPIYNNFFETISGTSTIRAYHQQQRFIRGNYYKVDENQLAYYPLVVSNRWLGLRLEFVGNLIIFFAALFAVVGRDSIESALVGMSITYALQITQTLNMMVRQTSELETNIVSVERTKEYADMETEAEWVVE-DSRPPKGWPDKGRIQIEDFDLRYRANLPLVLKNISVDIQPGEKIGIVGRTGAGKSTLTLALFRILESAGGRIVVDDLDISKMGLQDLRSSLTIIPQDPVLFSGTLRFNLDPFDAYSDEDLWEVLEVSHLKAFASGLPEGLLHPIAEGGENLSVGQRQLVCLARALLRKSKVLVLDEATAAVDLETDELIQNTIRTEFAERTVFTIAHRLNTIMDYSRILVLDKGFMMEFDSPQNLIAQ-RGIFYGMAQ 1217
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO35071 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SMJ8]) HSP 1 Score: 628.246 bits (1619), Expect = 0.000e+0 Identity = 382/1043 (36.63%), Postives = 594/1043 (56.95%), Query Frame = 3
Query: 1038 TWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMN----ILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLST-----------SGSQG--------FDGNENAEENYE---------KYFNDISHEEEIMSGRVSLNSIVW---------------YFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES--INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQ 4019
+W+G +YA + S+ + F + I+++ ++ G+I K LRL++ ++ +AGD++N+ VD +++++ Y +L S P QI++ + LY +G SI GV ++V +IP + + R ++K + + + + KV+K+Y WE+SF K+ IR +EL + +N F PFLV S TF IY + +I++A F+AI LFN ++ P+ +LP + + A VS R+ KFL +E+ + + + +S A I + +G FSW G P L NI L + + L+AVVG+VG GKS+LLSA+LGE + G V +G +AYVPQ+AWIQN TLR+N++ ++F+ Y K + C LE D + LP D TEIGERG+NLSGGQKQRV+LARAVY ++D+YLLDD LSAVD +VG+ +F+K+I +G L+ KTRVLVTHG+ +LP VD+I V+ D G++SE GTY+ L+ F FL + + Q S P+ + +R+ + SQG E+ +N + +YF S ++ + ++SI W Y K+ G+F+ IL ++ +WL + +N T + +R+ Y+ Y G Q V++ FG +RAS+ IH LL + + + FF TP GR++NRF+KDL+++D T+ + + + + I +L I+ TP F V IP+ I Y+L+Q Y++SSRQ +R++S + S + + ET SG+S IR+ + F Y +D++ +S RWL LRL+ +GNLI+F + +FAV+ R S+ ++LVG+SI+YALQ+T LN + RQ +E ETN VS+ER ++Y + E+ + E ++ + W G I +E+F L+Y NLP VLKNI+++I GEKIG+VGRTGAGKS+L LALFR++E GRI +D ++I+ +GL LR LTI+PQ
Sbjct: 15 SWEGYMYALIMFAAAAFQSILLHAYFHIVISAGIKIKTALTGLIYSKALRLNSVSRNKSTAGDMVNLMSVDAQRVLDMCTYINLLWSGPLQIVVALYFLYDTMGWSIVAGVVVMVLLIPFNLVVTRFSRKLQVCQFILIGVSLCQPPLCRCCLWGSCKVLKLYAWEESFMAKVTGIRNQELHHLKNAMYLNAFFGFTFTCAPFLV--SLATFAIYVLTGNILTANNAFVAISLFNILRFPLTVLPNVIISYVQAQVSLKRLTKFLTLDELDETNVHKKMPSHISNQA-IHVDDGSFSWDVTGQPTLHNINLNIPEGSLVAVVGQVGCGKSTLLSALLGETEKVTGEVYVKGSVAYVPQQAWIQNATLRDNVIFGRNFDSRRYHKTIKVCALETDFDILPAGDMTEIGERGINLSGGQKQRVNLARAVYFNADVYLLDDPLSAVDSHVGKHIFDKVIGPRGKLRKKTRVLVTHGISFLPQVDQIVVLQD-GRVSEVGTYKELLANRGAFAEFLKTFAPEEKSGDAAREQESCPDNSQGARVMSRQIAREQESCPDNSQGTRVMSRQIAREQESCPDNSQGTRRKTLRSRYFT--SKVAQLRHAK-PMDSITWSPYISFQVKWVVFWTYAKSIGVFIASIVILFMILSEGALVGSRIWLAAWS-----ADNDTSDATRD---MYLGGYAAFGFFQAFFVLVSSICLAFGSVRASRSIHDSLLIAIFHAPMSFFETTPLGRVVNRFSKDLYVVDDTVPRSTSGFLRTALSAIGTLFAITYATPLFLSVIIPLGIVYVLIQRLYVASSRQLKRIESVSKSPIYNNFFETISGTSTIRAYHQQQRFIRGNYYKVDENQLAYYPLVVSNRWLGLRLEFVGNLIIFFAALFAVVGRDSIESALVGMSITYALQITQTLNMMVRQTSELETNIVSVERTKEYADMETEAEWVVE-DSRPPKGWPDKGRIQIEDFDLRYRANLPLVLKNISVDIQPGEKIGIVGRTGAGKSTLTLALFRILESAGGRIVVDDLDISRMGLQDLRSSLTIIPQ 1041 HSP 2 Score: 104.76 bits (260), Expect = 1.822e-22 Identity = 68/262 (25.95%), Postives = 134/262 (51.15%), Query Frame = 3
Query: 3672 VSIERIRQYTMIPVESINETNNYIS-ENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAI---KFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSN 4445
VS++R+ ++ + ++ ++ETN + + +SN I++++ S +++ L NI +NI G + VVG+ G GKS+L AL E +G +++ G + +PQ I + TL+ N+ + + K++++ + + L G + G G NLS GQKQ + LAR + + + +LD+ ++VD + + + + + + T +++ H + + D+I+ L DG + E G+ KELL+N
Sbjct: 268 VSLKRLTKF--LTLDELDETNVHKKMPSHISNQAIHVDDGSFSWDVTGQPTLHNINLNIPEGSLVAVVGQVGCGKSTLLSALLGETEKVTGEVYVKG-------------SVAYVPQQAWIQNATLRDNVIFGRNFDSRRYHKTIKVCALETDFDILPAGDMTEIGERGINLSGGQKQRVNLARAVYFNADVYLLDDPLSAVDSHVGKHIFDKVIGPRGKLRKKTRVLVTHGISFLPQVDQIVVLQDGRVSEVGTYKELLAN 514
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO41257 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4U1]) HSP 1 Score: 606.675 bits (1563), Expect = 0.000e+0 Identity = 395/1185 (33.33%), Postives = 641/1185 (54.09%), Query Frame = 3
Query: 1008 NYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWI---VYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQL-PMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTR-IGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFN-----DISHEEEIMSGRVSLNSIVWYFKA-----TGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSL---------LNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLR-WLCLRLDILGNLIVFGSVIFAVLN----RFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
YF E + LYA + GL +F + N +RVR + +I +K L LS A A+ + G++IN+ D ++ +W+ + L+ P ++ + VLL+Y++G + GV ++V + P+++ + K + W D+R+ I+ EI+ G++VIKMY WE SF I +R+ ELK F + F L+ ++TF +Y + +++A KVF + LFN++++ L P+ +T + VS R + LL +E++ V + + + ++ +W + I P L + V L+ V+G VG GKSSLL+AILGE+ G+++ +G++AY Q+AW+ N+TLR+NIL K +++ Y V+ AC L+ D E L D+T +GERGV+LSGGQ+ R+SLARAVY D DIYLLDD LSAVD NVG+ LF + I LK K R+LVTH L++L DEI V+ QGQ ++GTY+ L + F S L E ++ N+++ S R S+ + N ++ + + EE G VS + Y ++ TG+F+ + C + V+ FG+VWL A+ + + +++T + SR +Y++ Y + G + ++ + + + AS+ +H+ + +++ + + FF+ GRILNRF+KD+ +ID + + D++ + + +++ P + +P++ + + +++ SSR+ +R++ S + H T G IR+ E+ F Q+ ++ YL+ + WL RL LG +VF ++F VL + LSA VGL +SY++ + + + AE E S+ER+ +YT +P E T+ +W G I +N S Y+ +LP VL N+T I EK+GVVGRTGAGKSSL LFRL E G I IDG+NI +GL LR +L+I+PQDPV+FSGT+++NLDPF E+ D L K L+ + V L ++ + G+N S+GQ+QL+CLAR +L+ S+I+++DEATA+VD TD + E I+ +F TV+ IAHRL TI+D D+++ LD G ++EF +P +LL + F L +
Sbjct: 95 TYFVEDSPITKKEAYLYAAGVGLCGLFILLFNVPFAFMKNVYGMRVRAACTALIYKKVLHLSRTALASTTTGNLINLVSADAQK-FDWVRLAPFLHYLILGPLEVGVVAVLLWYQIGPAALAGVGLLVCLAPMQVKMGNALMSLRGKAIHWMDERVKIMNEIIAGMRVIKMYTWEDSFAKLIMHLRKNELKWFLRMAYIQGAFASFFFSSAGLIYFTTF--LVYVLTGEVLTAAKVFTCVSLFNSVRIVCALFFPFAITLFNESRVSLKRFEEALLLDEMHSEGLVKSTLRPKAEECGVFVKKASATWNKEIAIPTLDGLSFDVPSGCLLGVIGAVGSGKSSLLNAILGELPLSEGSIRVQGRVAYASQQAWVYNSTLRHNILFGKEYDEHRYNDVIKACALDKDFELLSEGDETLVGERGVSLSGGQRARISLARAVYADGDIYLLDDPLSAVDANVGRHLFQECICT--YLKDKARILVTHQLQFLKDADEIMVLQ-QGQCIDKGTYQQLSRNDSGFLSLLAEEVEEETGNESDGDDGSTRFGRPVSKQLSVEEVVRKRAGNVVDSCMSIMSAATTLTLPPEETKQEGAVSRQTYAAYLRSFHDLGTGVFLIFLFAM-CQVRPVMLMFGDVWLANWANREEVYSMTLASWNASSNTTSPSRPDLHYYLSVYAALVFGLFVLCLICTMSYYWFTIVASRNLHNGMFHSLIHTNMHFFDNNSIGRILNRFSKDIGVIDDFMPWMLCDVLQIGFSCLGIMCLVAASNPVSIAIVLPVICLFFYFRNYFMKSSREMKRIEGINRSPLFGHFSTTLLGIDTIRAYGVEATFTD-QFNLFHDAHSRAWYAYLAGQAWLTCRLQALG--VVF--LLFIVLGLPALKDGLSAGTVGLILSYSIMLAKLFEPFVEESAEVENIMTSVERVVEYTSLPPEGEKVTDVIPPPDWPDKGKITFDNMSFSYHQSLPEVLHNVTCVIKPSEKVGVVGRTGAGKSSLLSTLFRLAEP-KGLIDIDGINIRKLGLKDLRSKLSIIPQDPVLFSGTMRKNLDPFSEHPDAGLWKVLDEVQLKQPVEDLPGKLDEELAEAGSNFSVGQRQLVCLARAILRHSRILVIDEATANVDPRTDALIQETIRDKFQDCTVLTIAHRLHTIMDSDRVMVLDAGRLVEFDAPYKLLKKRNTIFSGLVE 1266 HSP 2 Score: 75.8702 bits (185), Expect = 1.151e-13 Identity = 69/256 (26.95%), Postives = 117/256 (45.70%), Query Frame = 3
Query: 1884 ASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEG-------------KIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISE-RGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQ 2609
I N FS+ + VL N+ ++ + + VVGR G GKSSLLS + + G + +G K++ +PQ+ + + T+R N+ KVLD L+ +E LP + E+ E G N S GQ+Q V LARA+ + S I ++D+ + VD +L + I ++ + T + + H L + D + V+ D G++ E Y+ L T F + ++ K ++ Q
Sbjct: 1031 GKITFDNMSFSYHQSLPEVLHNVTCVIKPSEKVGVVGRTGAGKSSLLSTLF-RLAEPKGLIDIDGINIRKLGLKDLRSKLSIIPQDPVLFSGTMRKNLDPFSEHPDAGLWKVLDEVQLKQPVEDLPGKLDEELAEAGSNFSVGQRQLVCLARAILRHSRILVIDEATANVDPRT-DALIQETIRDK--FQDCTVLTIAHRLHTIMDSDRVMVL-DAGRLVEFDAPYKLLKKRNTIFSGLVEQTGGTEAKRLFDIAQ 1281
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO46846 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RP39]) HSP 1 Score: 592.808 bits (1527), Expect = 0.000e+0 Identity = 410/1229 (33.36%), Postives = 649/1229 (52.81%), Query Frame = 3
Query: 1014 FKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNF--RNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNP-------------------------VLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTV---QTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGML--------ADTQSLLNNSTFNQS-----------------RNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNR--FSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQY-TMIPVESINETN----------------NYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQA 4478
F E + G YA L+ L+ ++ + +KIS ++R ++I + KTL +S + +S+G+++N D ++++N+ S PFQI +++ LLY ++G + G+ + +IP+ + +KYS + + KD R+ I+ EIL GI+VIK Y WE +F NK+ + R ELK+ R Y WC+ + P ++ TFT Y+ + ++A KVF ++ LF + P+ PW + + A VS R+ FL E+ P + + Q S G +++I +G FSW R P +L + L++ K +LI V+G VG GKSSLLSA+ EM L G V +G V QE WIQ+ T++ NIL K ++ Y V++AC L D++SLP D TEIGE GVNLSGGQK RV LARAVYQ+ IYLLDD L+AVD +V L+ I+ GLL+HKT +L TH K+L D + V+++ G + G ++ SS+++ L Q S R+RS G + + N + + + EE G V L+ Y++A G + S +L+ ++ + G+ WL D + + + + + + +N+ KFY+ Y I + + + F +GG++A+K IH LL ++L + + FF+ TP GRI+NRF+ D++ ID +L + + + ++ SLV+ PW ++ P++I Y LQ +Y +SR+ +R+ + S + H ET +G S IR+L F + ++ + + + ++ WL LRL +G I G AVL ++ LVGL++SYAL VT + + AE E VS+ER QY T IPVE + +S +W ++G I N L Y LP L+N+++ I+ GEK+G+VGRTG+GKSSL L LFR+VE G + +DGVNI S+ L +LR +L I+PQDP +FSG+++ N+DP+ + +D L +LE + V+ L G++ + G G N S GQ+QL+CLAR +L ++KI+ +DEATASVD ETDR + I+ F +STV+ IAHR+ T++D D+++ ++ G++ EF P L++N + F +L +
Sbjct: 149 FMENKTEPVIHGYYYAMGVLVSALLTALTNCHFTYWVHKISYKIRAAIITTVYHKTLAVSTTSLGKFSSGEVLNFMSTDTDRVVNFANSFHQFWSLPFQIAVSLYLLYQQVGLAFLAGLGFALLLIPLNRWLAIKIQKYSTEMMTQKDSRVKIMNEILYGIRVIKFYAWENNFKNKVNTFRNAELKSLKGRKYLDAWCVY--FWATTPIIISILTFTTYVLM--GNQLTAAKVFTSVALFQMLITPLNAFPWVINGMMEAWVSVKRLQAFLTLEELDPDNYYIYIPAQ-SAGDAVQIVDGHFSW-RYKPPQQEAKETKDVENLAEIETEVKSTVGLLSGLNLSIRKGQLIGVIGGVGSGKSSLLSALTAEMDKLTGQVFVAGLDGGFGLVAQEPWIQHATVKENILFGKPYDVDKYSDVINACALREDLQSLPAGDDTEIGENGVNLSGGQKARVGLARAVYQNKSIYLLDDPLAAVDAHVAAHLYKHCIT--GLLRHKTVILCTHHTKFLSGADHVIVMSN-GTVMHSGPPSEIL------------SSERI------LRQISRDVSRERSLDGKEGGEDGEENADEPTGDGR----LVEEEAKDVGAVRLHVYGSYWRAIGHCLATSILLSLLLMQGSRTIGDWWLAYWISHSKIDHTDNATTITHHSHDSTHPEAPYAAPFLRGVNIKKNTLKFYLVVYAGIAVANTVFTLFRAFLFAYGGIKAAKTIHQRLLSSILAAPISFFDITPIGRIINRFSSDVYSIDDSLPFMLNIFLAQAYFVVASLVITCYGLPWMALLVAPLMIIYYYLQGYYRKTSRELKRIITVTESPIYAHFSETLTGLSTIRALRHTQRFRTENEERLEVNQRANYCEMVAYVWLVLRLQGIGVAINAGVAFLAVLEHHFHTVDPGLVGLAMSYALSVTQSIADMVNSFAETEKQMVSVERAEQYITRIPVEKPGGSKVCHAHILLLSSLSDISRLLSSSWPTHGRIRFHNIVLVYRPGLPPALRNVSLEIHAGEKVGIVGRTGSGKSSLFLVLFRMVEVAEGAVILDGVNIASLPLDKLRSRLAIIPQDPFLFSGSVRDNIDPWGKCSDRDLWITLERCHLQQPVSDLG-GLDAEVGERGRNFSAGQRQLVCLARAMLTRAKILCIDEATASVDMETDRFIQRTIREAFRTSTVLTIAHRIDTVMDSDRVLVMNKGTVTEFEKPDTLMANQNSLFYSLVHS 1345
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO38355 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SD35]) HSP 1 Score: 591.652 bits (1524), Expect = 0.000e+0 Identity = 418/1276 (32.76%), Postives = 671/1276 (52.59%), Query Frame = 3
Query: 795 EDIFRRASKSEDEEFL-----INSEEKESFILEHSGKVLIKSI---FGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVD---MEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPM-LLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFS--WTR-IGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRL---------STSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATG---------IFVFGSSILACVIFGVLQAFGNVWLGMLADTQ---SLL------NNSTFNQSRN---SAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILG----NLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQ 4475
ED++ K E + + EEKE+ L +S G HF +I L + + + +T P + L++YF + +YA + I + ++ + F T + +R + M+ RK + LS A +T + G IIN+ D +E++ ++ + WI P +++T V+ +YELG GV ++V + P++ + + K + DKR I+ E+++G++VIKMY WE+ F N + +R+ E+ R + + V++ + ++ ++ F Y+ + +S EKVF I LF +I++ + + LP + + VS R+ FL +E + V +T++ G + ++ FS W I P L+ I ++ L+ VVG VG GKSSLL +LGE+ +G + +G+++Y Q+AWI + ++R NIL K + + Y +V+ AC +E D+ PN +T +GE+GV LSGGQK R++LARAVY D+DI LLDD LSAVD +VG+ LF++ + GLLK + VLVTH L++L +I + D G+ +G+Y L + G + S ++ S + +N+I P N S + G Q GN + E + S E + +G V+ + YFKA + +FGS + V G WL AD++ S L NST + YI C G+I G + +++ + F AS+ +H + VLR+ + FF+ P GR++NRF KD+ +D L D + R L +TSL+ S+ P+ + IP+ + + ++ +Y+ +SR+ +RL++ S V +HL + +G IR+ +AE F + D + + + RWL RLDI+ L F S +F V S ++VGL ++YA Q+TG+ W RQ AE E N S+ER+ +Y+ I E ++W G I E+ Y+ +LP VLKN+ +I EK+G+VGRTGAGKSSL LFRL G + IDG+ I + L LR ++I+PQDPV+FSGTL++NLDPF +++DD L +LE + + V+ L +G+ + G+N S+GQ+QL+CLAR +L +KI+++DEATA+VD TD + E I+ +F TV+ IAHRL T++D D+++ LD G ++EF P LL NS G F L +
Sbjct: 20 EDLYEAMEKDESKRLTDKLERLWKEEKEAAKSSKRKPSLSRSFVRFLGTHFMLI---GLFAVAEEGMRITQPYFIGKLVSYFVPGSTTTKQEAYIYAAIMSIFSCVMAMVHHPLFFQTFRCGFHLRIACSTMVYRKAMCLSHSAYSTVTTGHIINLLTSDVQILERVAVFLHHLWI---APVLLLVTSVISWYELGPYCLPGVIVVVLIAPLQGWLGKKFAVIRNKTALQTDKRFRIMNEVISGMRVIKMYTWERPFANLVADVRRYEVSIIRKAAYLRSVNAVIYVMCIPVIGFAMFAPYV--LTGHALSPEKVFTVIALFYSIRVSLTIFLPECIRGLKESKVSAKRLQSFLERDEKHSMKGV-RTLTELKEGETASVKANNFSARWNDMISTPTLQGINFELKPSDLLMVVGPVGAGKSSLLMCLLGELPLTSGYISVKGRVSYASQQAWIFSGSVRENILFGKEYEEAKYWRVIKACAMERDMRLFPNGYETLVGEKGVALSGGQKARINLARAVYYDADIVLLDDPLSAVDTHVGRQLFDECV--YGLLKDRICVLVTHQLQYLKGATDIICLQD-GRCVGQGSYAELSEAGLDVMSLVSALSAG---DHDNIISPDIINVPPSSAQFPVPLANGSTRPGYQKISGNVDDAPEGEVLAREPSKEGQ-HTGTVTWQVYIEYFKAGASPCVRFLIVMLLFGSQAVVMV--------GEWWLAKWADSEKEKSYLIESYRGTNSTPPPPADLTTHEYIYIYC-GMICAGMVTSLVCAMMLYNFFVT-ASQHLHDNMFSRVLRAPIYFFDTNPVGRVVNRFAKDINQMDDVLPAAFYDFL-RVSLNLTSLLGSSM--PFLLVGAIPMTVLFGYIRNYYLRTSREVKRLEAINRSPVYSHLSTSLTGLITIRAFQAEQAFIRSYHAYTDFHTGSYFLFHTTQRWLGFRLDIICASFFTLATFTS-LFIVEGGLS---NVVGLCLTYATQLTGMFQWCIRQSAEVENNMTSVERVIEYSQIDQEVEPSKPLTAPDDWPHTGTITAESLYYSYHQSLPHVLKNVKFSIRNNEKVGIVGRTGAGKSSLLAVLFRL-NNPEGLVRIDGLPITDLKLQDLRSAISIIPQDPVLFSGTLRKNLDPFTQFSDDALWNALEEVQLKEAVDELPDGIETELAEGGSNFSVGQRQLVCLARAILSHNKILVIDEATANVDHSTDSLIQETIRNKFHDCTVLTIAHRLNTVMDSDRVMVLDAGRLVEFDEPYVLLLNSQGFFSQLVE 1261
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: abcc1 (multidrug resistance-associated protein 1 [Source:NCBI gene;Acc:101173789]) HSP 1 Score: 832.017 bits (2148), Expect = 0.000e+0 Identity = 496/1319 (37.60%), Postives = 781/1319 (59.21%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLI------NSEEKESFILEHSGKVLIKS---------------IFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLI----QGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL-----NESSDKVDKNQNNLIQP---SAPNKRKRSRLSTSGSQGFDGNENAEENYEK--YFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPIL-ICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES-INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFK 4463
PE AS S++T+ W+ + + YK + +K + L+ ++S + Q + +R +E+ L + E KE +E S +++KS F HF L++CL ++++DIL+ P +L+LL+ + + +W+G YA + + Q LI + + CF +R+R +VIG I RK L +S+ A+ + + G+I+N+ VD ++ M+ + Y ++ S P Q++L + L+ LG S+ GVA+++ ++P+ I TK Y ++ KD R+ ++ E+LNGIKV+K+Y WE +F K+ IR+ ELK + + + + PFLV STF+ Y+ +++ AEK F+++ LFN ++ P+ +LP ++ + A VS R+ + LS+E SV SP SI I++G FSW+R +P LK + + + + L+AVVG VG GKSSLLSA+LGEM + G+V +G +AYVPQ+AWI N TL+NNI+ + + +Y +V++AC L D+E LP D+TEIGE+GVNLSGGQKQRVSLARAVY D +YLLDD LSAVD +VG+ +F+ +I QGLLK KTR+LVTHGL +LP + V+ D G+I+E G+Y+ L + F FL NE S++ + N+ +P S+ +++ S+G +N E+ K + ++ ++GRV L+ Y KA G+ + S+L + +L F N WL + D + N ++ + + YG +G+ Q +AV + GG+ AS+ +H +L VLRS + FF TPSG ++NRF K++ ID + + + + ++ S ++I + TP ++ IP L + Y +Q FY++SSRQ +RL+S + S + TH ET G+S+IR+ + F + +D + K ++ RWL +RL+ +GN IV + +FAVL R SLS ++GLSISYALQ+T L WL R ++ ETN V++ER+++Y+ E+ + +W + G I + NF L+Y +L ++NI ++I+GGEK+G+VGRTGAGKSSL L LFR++E G IFIDGV+I +GLH+LR ++TI+PQDPV+FSGTL+ NLDPFD Y+D+ + K+LE S + +V+ L + + ++C G NLS+GQ+QL+CLAR LL+K+K+++LDEATA++D ETD + I+ QF TV+ IAHRL TI+D +++ LD G + EF SP L++ ++
Sbjct: 209 PEPGASFLSRITFWWISGMMLSGYKRPLEEKDLWSLNPEDRSHC---VVPQLLRRWTAECHKVKRT----EEKMLYSPKQPPHGENKEVRAVEESEILIVKSPKKSREPSLLWALCLTFAPHF---LVSCLYKLIQDILMFVGPEILRLLILFVNDPDAP-SWQGYFYAALLFVCTCVQSLILQRYFHVCFV----SGMRLRTAVIGAIYRKALVISSAARRSSTVGEIVNLMSVDAQRFMDLVTYINMIWSAPLQVVLALYFLWENLGPSVLAGVAVMILMVPINAVIAMKTKTYQVAQMKNKDSRIKLMNEMLNGIKVLKLYAWEMAFKEKVSQIRENELKVLKKAAYLGAVSTFTWVCAPFLVALSTFSVYVLIDDQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRL-RVFLSHEELQEDSVERPAAGGSP-YSISIEDGVFSWSRSESPTLKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSVSVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLSGGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVMVD-GEITEVGSYQQLKEKEGAFAEFLRMYAANEQSEETEPVPNSPTKPMENGVGPGFTGSQSASNVSKGSVSEQNVEQKNSKNAEAGKTTDADKALTGRVKLSVFFSYLKAIGVLLSIISLLFFLSHNLLSLFANYWLSLWTD------DPVVNGTQPNRLMRLGVYGALGVSQGVAVCGYSLSVSIGGILASRFLHQSMLFDVLRSPMSFFERTPSGNLVNRFAKEMDTIDSVIPMILKMFMGSLFNVVGSCIIILVATPMVALI-IPFLGVLYFFVQRFYVASSRQLKRLESVSRSPIYTHFSETLLGTSVIRAFGEQERFIHESDQRVDHNQKAYYPGIVANRWLAVRLEFVGNCIVSFAALFAVLARESLSPGIMGLSISYALQLTASLTWLVRMSSDVETNIVAVERVKEYSDTEKEAEWRHEPPTVPPDWPTEGCIRITNFGLRYRSDLDLAIRNINVDISGGEKVGIVGRTGAGKSSLTLGLFRIIEPAEGNIFIDGVDIAKLGLHELRSRITIIPQDPVLFSGTLRMNLDPFDSYSDEDIWKALEFSHLKSFVSGLPDKLGHECSEGGENLSLGQRQLLCLARALLRKTKVLVLDEATAAIDMETDDLIQTTIRSQFEGCTVLTIAHRLNTIMDYTRVLVLDKGQMAEFDSPSNLIAQKGAFYR 1502
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: abcc6a (multidrug resistance-associated protein 1 [Source:NCBI gene;Acc:101158001]) HSP 1 Score: 827.395 bits (2136), Expect = 0.000e+0 Identity = 485/1341 (36.17%), Postives = 778/1341 (58.02%), Query Frame = 3
Query: 594 PNLRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKS-----------EDEEFLINSEEKESFILEHSGKVLIKSI---FGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENY----CFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLST----------SGSQGFDGN-------------ENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNV----WLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVE-SINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQA 4478
PNL + P AS S++ + W + Y+ T + DL + + + +I + +G ++ KS D+ L+ +KE + SG L++++ FG +F L L I D + +P VL LLL + ++ + WKG YA + + + S+F + CFT + +RV+ +V+G++ RK+L +++ A+ T + G+I+N+ D +++M+++VY + P +I L + L+ LG S G+A ++ + P+ I + K E ++ + D R+ ++ EILNGIK++K Y WEK+F ++ R++ELK + + + I F+ FL+ ++ F Y+ +++ A+KVF+++ L N ++ P+ LP+ ++ T+ A+VS R+GK+L S E+ + + S G + I+NG FSW++ G P LK I + V + L+AVVG VG GKSSLLSA+LGE +G V +G +AYVPQ+AWIQN T+++NIL + K +Y +VL+AC L D++ LP D TEIGE+G+NLSGGQKQRVSLARAVY+ +D+YLLDD LSAVD +VGQ +F+K+I +G+LK +TR+LVTHG+ +LP D I V+ D G+I+E G+Y+ L+ F F++ + + + + IQ A ++R +RLS S Q G+ EN ++ + ++ ++ +GRV L+ YFK G+ + I+ V Q ++ WL M AD + N ++ + +G +G Q +A+ G+ AS+++H LL VLRS + FF +TPSG +LNRF K++ ID + + +++ L+ +++ I TP ++ +P+ Y +Q FY+++S Q RRL++ + S + TH ET G+S+IR+ +S F +D + ++++ RWL + L+ +GN +V + + +V+ + ++S +VGL++S++LQVTGIL+W+ R + E N VS+ER+ +Y P E S N + + W +G I +++ LQY L LK IT+ I EKIG+VGRTGAGKSSLAL +FR++E GRIFIDGVNI IGLH LR ++TI+PQDPV+FSG+L+ NLDPFD YTD+++ SLE++ + D+V++L + +N++C G NLS+GQ+QL+CLAR LL+K+KI++LDEATA+VD ETD + I+ QF TV+ IAHRL TI+D ++I +D G I E SP L+S ++ +A
Sbjct: 198 PNLEKNPCPVKDASFLSKILFWWFTGLVVKGYR---TPLEATDLWTLREEDTSHKIISDLQQEWGAECAKLQKQEKSLESAPVLGSRLPDQAQLLRKLQKE----QSSGFFLLRTLARKFGPYF---LTGTLCIIFHDAFMFAIPQVLSLLLGFIRDPEAP-QWKGYFYATLMFLLSCLQSLFNHQYMYTCFT----VGMRVKTAVMGLVYRKSLVINSAARRTCTVGEIVNLVSADTQKLMDFVVYFNAVWLAPIEIGLCLFFLWQHLGPSALAGIATVILIFPLNGFIAKKRSKLQEIQMKFMDGRVRLMNEILNGIKILKFYAWEKAFLEQVLGYREKELKALKKSQVLYSISIASFNSSSFLIAFAMFGVYVMLDERNVLDAQKVFVSMALINILKTPLSQLPFAISTTMQALVSLRRLGKYLCSEELKVDGVSKALSS--SDGEDVVIENGTFSWSKEGPPCLKRISVRVPRGSLVAVVGHVGSGKSSLLSAMLGETEKRSGQVTVKGSVAYVPQQAWIQNATVQDNILFGREKLKTWYQRVLEACALLPDLDILPAGDATEIGEKGLNLSGGQKQRVSLARAVYRKADLYLLDDPLSAVDAHVGQHIFDKVIGPKGVLKDRTRILVTHGMSFLPQADLILVLID-GEITESGSYQELLSHHGAFADFIHTFAST--EKKESAIQ-RAGSRRSNARLSMVDFMPFSRDLSQEQLIGGDTTNTNLQNMEPVSENDQDQVPEDLGKLTEADKAHTGRVKLDMYKKYFKTIGLAI----IIPIVFLYAFQQGASLAYSYWLSMWAD------DPVVNGTQTDRDLKLAVFGALGFVQGIAIFGTTVAISICGIIASRQLHMDLLVNVLRSPMAFFESTPSGNLLNRFVKEIDAIDCMVPEGLKMMLSYVFKLVEVCIIVLIATPIAAVIILPLAFLYAFVQSFYVATSCQLRRLEAVSRSPIYTHFNETVQGASVIRAFGEQSRFIMQANERVDFNQTSYFPRFVATRWLAVNLEFVGNGVVLAAAVLSVIGKSTVSPGIVGLAVSHSLQVTGILSWIVRSWTDVENNIVSVERVNEYADTPKEASWNTEGSALPLAWPQSGTIEFQDYGLQYRKGLELALKGITLQIQKREKIGIVGRTGAGKSSLALGIFRILEAAKGRIFIDGVNIAEIGLHDLRSRITIIPQDPVLFSGSLRMNLDPFDIYTDEEIWSSLELAHLKDFVSNLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDTLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVMDRGYISEMDSPANLISQRGQFYRMCREA 1507
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: ENSORLT00000010371.2 (canalicular multispecific organic anion transporter 1 [Source:NCBI gene;Acc:101165337]) HSP 1 Score: 825.083 bits (2130), Expect = 0.000e+0 Identity = 509/1380 (36.88%), Postives = 808/1380 (58.55%), Query Frame = 3
Query: 594 PNLRE--TKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSS---------INSEISA---QYFHNYGEREDIFRRASKSEDEEFLINSE-----EKESFILEHSGKV-------------------LIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLI----------------------QPSAPN--------KRKRSRLSTSGSQGFDGNENA------EENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQ-AF--GNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHED 4502
P RE ++PEI AS S++T+ W +S + YK + + +DL+ + +S ++ E++A +Y + + I + S++E E I++ +++ ++E GK L+ +++ +++ + ++++D+L P +LKL+++ F + ++ W+G +YA + L+ ++ S+F F + ++VR +V+ + +K L +S + + + G+ +N+ D ++ + + +L SCP QII+++V L+ ELG S+ G+ ++V ++P+ + +KY + + +KDKRM I+ E+LNG+K++K++ WE SF +++ESIR EELK + ++ + +F P LV ++F ++ P +I++AEK F +I LFN ++ P+ +LP + + VS R+ KFL ++ P +V S +++ ++NG FSW R P+LK++ L +E +L+AVVG VG GKSSL+SA+LGEM+ G + +G +A+VPQ+AWIQN TLR+NIL + + +V+ AC L D++ L + TEIGE+G+NLSGGQKQRVSLARA Y +DIYLLDD LSAVD +VG+ LF+K+I G+LKHKTR+LVTHG+ +LP+VDE+ V+ D G+ISE G+Y L F FL D K QNN QP +P KR+ S + S +N+ + N K + +E + +G+V + + Y +A G +G + + +I+ + AF N+WL + + N T+ + + + +G +G+ Q V L + AS+ +HS LL+ +LR + FF+ TP GR++NRF KD+F ID + + + + ++ +L VI + TP+F I+ +P+ + Y +Q FY+++SRQ RRLDS + S + +H ET SG S+IR+ + F ID++ K +S RWL +RL+ LGNL+VF S +FAV+++ SL + LVGL+ISYAL VT LNWL R +E ETN V++ER+ +YT I E+ T+ E W G + ++ ++Y L VL IT NI EKIG+VGRTGAGKSSL LFR++E GRI ID V+I++IGLH LR +LTI+PQDPV+FSGTL+ NLDPFD+++D++L K+LE+S + D+V L EG+ ++ G NLS+GQ+QL+CLAR LL+KS+I+ILDEATA+VD ETD + I+ +F TV+ IAHRL +I+D +++ LD G I+EF SP LL N G+F ++A+ D I E+
Sbjct: 52 PEARERAKRNPEIGASFLSRITFNWFNSMVVTGYKRPLVQEDMWDLNEKDGTSYLSQRFQHHMDFELAAARVRYQNKLKKHLVIHKGRSQAEASENGISNGLGKGVSRDALMMEDKGKSTEKKKKKKEKKEEDYPNSWLLSTMYKTFKWLLIESAFFKLLQDLLAFVSPQLLKLMIS-FTQNPNSFVWEGYMYAVLLLLVAILQSLFLQQYFQRCFVLGMKVRTAVMAAVYKKALVVSNDTRKESTVGETVNLMSADAQRFNDVTNFIHLLWSCPLQIIVSIVFLWLELGPSVLAGLLVMVLMVPINGLLATQARKYQVQNMNFKDKRMKIMNELLNGVKILKLFAWEPSFQSQVESIRGEELKVMKKFAYLSSVSTFIFSCAPALVSLASFAVFVLVSPDNILTAEKAFTSISLFNILRFPLAMLPMLIASIVQTGVSKKRLEKFLGGEDLEP----DIVRHDPSFDSAVSVRNGSFSWERDAEPLLKDVSLDIEPGRLVAVVGAVGSGKSSLMSALLGEMHCTEGFINIKGSLAFVPQQAWIQNATLRDNILFGSPHEEKRFQEVIQACALGPDLKLLAAGELTEIGEKGINLSGGQKQRVSLARAAYSQADIYLLDDPLSAVDSHVGKHLFDKVIGPNGVLKHKTRILVTHGVSFLPYVDEVVVLVD-GKISEIGSYNSLRASKGAFSEFL----DTYAKEQNNQTKSDKDGCQDTEDLEIIPEREDTQPDSPLEDTVSFTLKRENSIRRSQRSSSVRVRKNSTVKKSEDANETKAGQRLIEKETMETGQVKFSVYLQYLRALG---WGYTSMVFIIYFIQNVAFIGQNLWLSDWTNDAADYYNQTYPNWKRDTR--VGVFGALGIAQGFLVFLGTLLLANASVSASRILHSRLLNNILRVPMVFFDTTPVGRVVNRFAKDIFTIDEAIPQSFRSWLLCLLGVLGTLFVICLATPFFTIIILPLAVIYFFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYRHQDRFLKHNEVTIDENLKSVYPWIVSNRWLAIRLEFLGNLVVFFSALFAVISKDSLDSGLVGLAISYALNVTQTLNWLVRMSSELETNIVAVERVSEYTEIENEAKWITDCRPPERWPDEGKLQFIDYKVRYRPGLDLVLHGITCNIASSEKIGIVGRTGAGKSSLTNCLFRIIEAAEGRILIDDVDISTIGLHDLRGRLTIIPQDPVLFSGTLRMNLDPFDKFSDEELWKALELSHLKDYVAGLQEGLQHEVAEGGENLSVGQRQLLCLARALLRKSRILILDEATAAVDLETDNLIQNTIRKEFAHCTVLTIAHRLHSIMDSSRVMVLDAGKIVEFDSPSNLLEN-RGYFFSMAK-DAGITQEE 1414
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: abcc1 (multidrug resistance-associated protein 1 [Source:NCBI gene;Acc:101173789]) HSP 1 Score: 813.527 bits (2100), Expect = 0.000e+0 Identity = 488/1289 (37.86%), Postives = 765/1289 (59.35%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLI------NSEEKESFILEHSGKVLIKS---------------IFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLI----QGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL-----NESSDKVDKNQNNLIQP---SAPNKRKRSRLSTSGSQGFDGNENAEENYEK--YFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPIL-ICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES-INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIID 4373
PE AS S++T+ W+ + + YK + +K + L+ ++S + Q + +R +E+ L + E KE +E S +++KS F HF L++CL ++++DIL+ P +L+LL+ + + +W+G YA + + Q LI + + CF +R+R +VIG I RK L +S+ A+ + + G+I+N+ VD ++ M+ + Y ++ S P Q++L + L+ LG S+ GVA+++ ++P+ I TK Y ++ KD R+ ++ E+LNGIKV+K+Y WE +F K+ IR+ ELK + + + + PFLV STF+ Y+ +++ AEK F+++ LFN ++ P+ +LP ++ + A VS R+ + LS+E SV SP SI I++G FSW+R +P LK + + + + L+AVVG VG GKSSLLSA+LGEM + G+V +G +AYVPQ+AWI N TL+NNI+ + + +Y +V++AC L D+E LP D+TEIGE+GVNLSGGQKQRVSLARAVY D +YLLDD LSAVD +VG+ +F+ +I QGLLK KTR+LVTHGL +LP + V+ D G+I+E G+Y+ L + F FL NE S++ + N+ +P S+ +++ S+G +N E+ K + ++ ++GRV L+ Y KA G+ + S+L + +L F N WL + D + N ++ + + YG +G+ Q +AV + GG+ AS+ +H +L VLRS + FF TPSG ++NRF K++ ID + + + + ++ S ++I + TP ++ IP L + Y +Q FY++SSRQ +RL+S + S + TH ET G+S+IR+ + F + +D + K ++ RWL +RL+ +GN IV + +FAVL R SLS ++GLSISYALQ+T L WL R ++ ETN V++ER+++Y+ E+ + +W + G I + NF L+Y +L ++NI ++I+GGEK+G+VGRTGAGKSSL L LFR++E G IFIDGV+I +GLH+LR ++TI+PQDPV+FSGTL+ NLDPFD Y+D+ + K+LE S + +V+ L + + ++C G NLS+GQ+QL+CLAR LL+K+K+++LDEATA++D ETD + I+ QF TV+ IAHRL TI+D
Sbjct: 247 PEPGASFLSRITFWWISGMMLSGYKRPLEEKDLWSLNPEDRSHC---VVPQLLRRWTAECHKVKRT----EEKMLYSPKQPPHGENKEVRAVEESEILIVKSPKKSREPSLLWALCLTFAPHF---LVSCLYKLIQDILMFVGPEILRLLILFVNDPDAP-SWQGYFYAALLFVCTCVQSLILQRYFHVCFV----SGMRLRTAVIGAIYRKALVISSAARRSSTVGEIVNLMSVDAQRFMDLVTYINMIWSAPLQVVLALYFLWENLGPSVLAGVAVMILMVPINAVIAMKTKTYQVAQMKNKDSRIKLMNEMLNGIKVLKLYAWEMAFKEKVSQIRENELKVLKKAAYLGAVSTFTWVCAPFLVALSTFSVYVLIDDQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRL-RVFLSHEELQEDSVERPAAGGSP-YSISIEDGVFSWSRSESPTLKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSVSVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLSGGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVMVD-GEITEVGSYQQLKEKEGAFAEFLRMYAANEQSEETEPVPNSPTKPMENGVGPGFTGSQSASNVSKGSVSEQNVEQKNSKNAEAGKTTDADKALTGRVKLSVFFSYLKAIGVLLSIISLLFFLSHNLLSLFANYWLSLWTD------DPVVNGTQPNRLMRLGVYGALGVSQGVAVCGYSLSVSIGGILASRFLHQSMLFDVLRSPMSFFERTPSGNLVNRFAKEMDTIDSVIPMILKMFMGSLFNVVGSCIIILVATPMVALI-IPFLGVLYFFVQRFYVASSRQLKRLESVSRSPIYTHFSETLLGTSVIRAFGEQERFIHESDQRVDHNQKAYYPGIVANRWLAVRLEFVGNCIVSFAALFAVLARESLSPGIMGLSISYALQLTASLTWLVRMSSDVETNIVAVERVKEYSDTEKEAEWRHEPPTVPPDWPTEGCIRITNFGLRYRSDLDLAIRNINVDISGGEKVGIVGRTGAGKSSLTLGLFRIIEPAEGNIFIDGVDIAKLGLHELRSRITIIPQDPVLFSGTLRMNLDPFDSYSDEDIWKALEFSHLKSFVSGLPDKLGHECSEGGENLSLGQRQLLCLARALLRKTKVLVLDEATAAIDMETDDLIQTTIRSQFEGCTVLTIAHRLNTIMD 1510
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: abcc1 (multidrug resistance-associated protein 1 [Source:NCBI gene;Acc:101173789]) HSP 1 Score: 813.142 bits (2099), Expect = 0.000e+0 Identity = 486/1285 (37.82%), Postives = 763/1285 (59.38%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLI------NSEEKESFILEHSGKVLIKS---------------IFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFL-----NESSDKVDKNQNNLIQP---SAPNKRKRSRLSTSGSQGFDGNENAEENYEK--YFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPIL-ICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVES-INETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIID 4373
PE AS S++T+ W+ + + YK + +K + L+ ++S + Q + +R +E+ L + E KE +E S +++KS F HF L++CL ++++DIL+ P +L+LL+ + + +W+G YA + + + S+ F + +R+R +VIG I RK L +S+ A+ + + G+I+N+ VD ++ M+ + Y ++ S P Q++L + L+ LG S+ GVA+++ ++P+ I TK Y ++ KD R+ ++ E+LNGIKV+K+Y WE +F K+ IR+ ELK + + + + PFLV STF+ Y+ +++ AEK F+++ LFN ++ P+ +LP ++ + A VS R+ FL S+E SV SP SI I++G FSW+R +P LK + + + + L+AVVG VG GKSSLLSA+LGEM + G+V +G +AYVPQ+AWI N TL+NNI+ + + +Y +V++AC L D+E LP D+TEIGE+GVNLSGGQKQRVSLARAVY D +YLLDD LSAVD +VG+ +F+ +I QGLLK KTR+LVTHGL +LP + V+ D G+I+E G+Y+ L + F FL NE S++ + N+ +P S+ +++ S+G +N E+ K + ++ ++GRV L+ Y KA G+ + S+L + +L F N WL + D + N ++ + + YG +G+ Q +AV + GG+ AS+ +H +L VLRS + FF TPSG ++NRF K++ ID + + + + ++ S ++I + TP ++ IP L + Y +Q FY++SSRQ +RL+S + S + TH ET G+S+IR+ + F + +D + K ++ RWL +RL+ +GN IV + +FAVL R SLS ++GLSISYALQ+T L WL R ++ ETN V++ER+++Y+ E+ + +W + G I + NF L+Y +L ++NI ++I+GGEK+G+VGRTGAGKSSL L LFR++E G IFIDGV+I +GLH+LR ++TI+PQDPV+FSGTL+ NLDPFD Y+D+ + K+LE S + +V+ L + + ++C G NLS+GQ+QL+CLAR LL+K+K+++LDEATA++D ETD + I+ QF TV+ IAHRL TI+D
Sbjct: 209 PEPGASFLSRITFWWISGMMLSGYKRPLEEKDLWSLNPEDRSHC---VVPQLLRRWTAECHKVKRT----EEKMLYSPKQPPHGENKEVRAVEESEILIVKSPKKSREPSLLWALCLTFAPHF---LVSCLYKLIQDILMFVGPEILRLLILFVNDPDAP-SWQGYFYAALLFVCTCVQSLILQRYFHVCFVSGMRLRTAVIGAIYRKALVISSAARRSSTVGEIVNLMSVDAQRFMDLVTYINMIWSAPLQVVLALYFLWENLGPSVLAGVAVMILMVPINAVIAMKTKTYQVAQMKNKDSRIKLMNEMLNGIKVLKLYAWEMAFKEKVSQIRENELKVLKKAAYLGAVSTFTWVCAPFLVALSTFSVYVLIDDQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFL-SHEELQEDSVERPAAGGSP-YSISIEDGVFSWSRSESPTLKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSVSVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLSGGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVMVD-GEITEVGSYQQLKEKEGAFAEFLRMYAANEQSEETEPVPNSPTKPMENGVGPGFTGSQSASNVSKGSVSEQNVEQKNSKNAEAGKTTDADKALTGRVKLSVFFSYLKAIGVLLSIISLLFFLSHNLLSLFANYWLSLWTD------DPVVNGTQPNRLMRLGVYGALGVSQGVAVCGYSLSVSIGGILASRFLHQSMLFDVLRSPMSFFERTPSGNLVNRFAKEMDTIDSVIPMILKMFMGSLFNVVGSCIIILVATPMVALI-IPFLGVLYFFVQRFYVASSRQLKRLESVSRSPIYTHFSETLLGTSVIRAFGEQERFIHESDQRVDHNQKAYYPGIVANRWLAVRLEFVGNCIVSFAALFAVLARESLSPGIMGLSISYALQLTASLTWLVRMSSDVETNIVAVERVKEYSDTEKEAEWRHEPPTVPPDWPTEGCIRITNFGLRYRSDLDLAIRNINVDISGGEKVGIVGRTGAGKSSLTLGLFRIIEPAEGNIFIDGVDIAKLGLHELRSRITIIPQDPVLFSGTLRMNLDPFDSYSDEDIWKALEFSHLKSFVSGLPDKLGHECSEGGENLSLGQRQLLCLARALLRKTKVLVLDEATAAIDMETDDLIQTTIRSQFEGCTVLTIAHRLNTIMD 1472
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000074229.1 (SMESG000074229.1) HSP 1 Score: 2739.14 bits (7099), Expect = 0.000e+0 Identity = 1426/1503 (94.88%), Postives = 1453/1503 (96.67%), Query Frame = 3
Query: 15 MNCTLCLCQDSFWSNSHLQSPNYPIFTNCFQYTLLIIGPSIFFITFSILLLERLFNKKHLKIITFHSFDLRHSXXXXXXXXXXXXVFAEMLIDNLYTTNKDSMLFISCGXXXXXXXXXXXXTELRRRGNKSIDVILFVFWWMVFCGYFFRYYSHFIALLQNSKPNRXXXXXXXXXXXXXXXXXXXXDTFLRFPPNLRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXX--------------XAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQAD 4481
MNCTLCLCQDSFWSNSH QSPNYPIFTNCFQYTLLIIGPSIFFI FSILLLE LFNKKHLKIITFHSFDLRHSIKIILPILGGILVFAEMLIDNLYTTNKDSMLFISCGLLSASLFSVSFATELRRRGNKSIDVILFVFWWMVFCGYFFRYYSHFIALLQNSKPNRIILFLFSSFAILIFIVSIILDTFLRFPPNLRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDILILTLPLVLKLLLNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIR EELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSP ASIEIQ+GRFSWT+IGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNG VQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYG VLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQ + L SAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVILFWGGF FGGLRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRF+KDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAV+NRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNIT+NINGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVN L +G+ YDCG MG NLS GQKQL+CLART+LK SKIIILDEATASVDE+TDRRV +AI QF +STVIIIAHR+KTII CDKI++ ++GS++EFGSP+ELL ++G F+ +++
Sbjct: 1 MNCTLCLCQDSFWSNSHFQSPNYPIFTNCFQYTLLIIGPSIFFIMFSILLLESLFNKKHLKIITFHSFDLRHSIKIILPILGGILVFAEMLIDNLYTTNKDSMLFISCGLLSASLFSVSFATELRRRGNKSIDVILFVFWWMVFCGYFFRYYSHFIALLQNSKPNRIILFLFSSFAILIFIVSIILDTFLRFPPNLRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDILILTLPLVLKLLLNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRHEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPDASIEIQSGRFSWTKIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGAVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGTVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQVNLKGKFQILKYFKDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVILFWGGFTFGGLRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFSKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVVNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITMNINGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNLLKDGLYYDCGYMGANLSTGQKQLVCLARTVLKNSKIIILDEATASVDEDTDRRVFDAITSQFRNSTVIIIAHRIKTIIGCDKILYFENGSVVEFGSPQELLLKANGKFRFFVKSE 1503
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000074229.1 (SMESG000074229.1) HSP 1 Score: 2507.64 bits (6498), Expect = 0.000e+0 Identity = 1288/1362 (94.57%), Postives = 1315/1362 (96.55%), Query Frame = 3
Query: 438 MVFCGYFFRYYSHFIALLQNSKPNRXXXXXXXXXXXXXXXXXXXXDTFLRFPPNLRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXX--------------XAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQAD 4481
MVFCGYFFRYYSHFIALLQNSKPNRIILFLFSSFAILIFIVSIILDTFLRFPPNLRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDILILTLPLVLKLLLNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIR EELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSP ASIEIQ+GRFSWT+IGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNG VQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYG VLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQ + L SAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVILFWGGF FGGLRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRF+KDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAV+NRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNIT+NINGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVN L +G+ YDCG MG NLS GQKQL+CLART+LK SKIIILDEATASVDE+TDRRV +AI QF +STVIIIAHR+KTII CDKI++ ++GS++EFGSP+ELL ++G F+ +++
Sbjct: 1 MVFCGYFFRYYSHFIALLQNSKPNRIILFLFSSFAILIFIVSIILDTFLRFPPNLRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDILILTLPLVLKLLLNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRHEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSPDASIEIQSGRFSWTKIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGAVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGTVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQVNLKGKFQILKYFKDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVILFWGGFTFGGLRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFSKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVVNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITMNINGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNLLKDGLYYDCGYMGANLSTGQKQLVCLARTVLKNSKIIILDEATASVDEDTDRRVFDAITSQFRNSTVIIIAHRIKTIIGCDKILYFENGSVVEFGSPQELLLKANGKFRFFVKSE 1362
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000074226.1 (SMESG000074226.1) HSP 1 Score: 2136.69 bits (5535), Expect = 0.000e+0 Identity = 1127/1429 (78.87%), Postives = 1233/1429 (86.28%), Query Frame = 3
Query: 270 VFAEMLIDNLYTTNKDSMLFISCGXXXXXXXXXXXXTELRRRGNKSIDVILFVFWWMVFCGYFFRYYSHFIALLQNSKPNRXXXXXXXXXXXXXXXXXXXXDTFLRFPPNLRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGEREDIFRRASKSEDEEFLINSEE-KESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRS--SVPLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXX--------------XAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDGNENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHEDK 4505
+ E+L +N+ ++DS+L IS G L AS+ F EL RRGN V+LF++ W++F GY R+Y++ I L+ S R+I F SS +++ +S+I+D+ + N T++PE +S+ SQ+TY WMD +IY W+K +M D+TSFDL++TE SS NSE +Y +I ED++ LI + E F ++SGK LIKS+ +F II +L+I RDIL+LTLPLVLKLLLNY K K +YTWKG+L A +F QGL GS+ ENYCF +T+KI++RVR ++ GMI +KTLRLS EA++ +SAGDI+NM VDMEQ+MN I YSWI +SCPFQIIL ++LLY ELG SIF GV I +IP+ I IM+ ++K+SE+EL++KDKRM+ILTEI +G+K+IKMY WEK F KIE IR +E+KN RN S+GWCI++V++DLVPF VMY TFTF+IYFVP S+I+ EK+F+++VLFNN+QLP+LLLPWG++Q I+A+VSFGRI FLL++E S S+P +MSPGA IEIQNG FSWT G P L NI L VEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNG VQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKI YG VLDACCLEYDI SLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQ + L SAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFD NENAEENYEKYFNDIS EEEIMSGRVSLNSIVWYFKATGIFVF SSILACVIFGVLQA GNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVILFWGGF FG LRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDH LNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLK NLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHEDK
Sbjct: 11 LMVEILEENVLNKDQDSLLIISYGSLMASMIVAVFTMELGRRGNHFFKVVLFIYSWLIFGGYAIRFYNNLIKFLKYSTKMRMIYFSISSVIMILLFLSVIMDSISCYYTN-DLTENPENFSSVLSQITYVWMDKYIYQWFKEEMKDETSFDLNNTETSSENSEKCLKYLKENLRSPNIESEIHDIEDKKCLIGKKNFNEEF--KYSGKFLIKSLCRVYFPIIFFGWILKIFRDILVLTLPLVLKLLLNYLKNKDLSYTWKGILMALLFFFQGLFGSLCENYCFAITSKITVRVRAALCGMIYKKTLRLSTEARSIHSAGDIVNMASVDMEQVMNAITYSWIFISCPFQIILAILLLYLELGYSIFAGVTAIGAIIPLNIIIMKFSRKFSERELLFKDKRMSILTEIFHGMKIIKMYAWEKCFNKKIEEIRNDEIKNIRNVSVGWCIMSVLWDLVPFFVMYITFTFFIYFVPNSLITPEKIFVSLVLFNNLQLPILLLPWGLSQAISALVSFGRIENFLLASEKENDSNNSMP---RKMSPGAPIEIQNGSFSWTEDGRPTLNNINLNVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGAVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKILYGTVLDACCLEYDIGSLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQVNLKGKFQILKYFKDSDIYLLDDPLSAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNESSDKVDKNQNNLIQPSAPNKRKRSRLSTSGSQGFDDNENAEENYEKYFNDISQEEEIMSGRVSLNSIVWYFKATGIFVFASSILACVIFGVLQAIGNVWLGMLADTQSLLNNSTFNQSRNSAKFYINCYGIIGLGQLLAVILFWGGFTFGSLRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHILNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKHNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKALAQADEYIKHEDK 1433
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000000283.1 (SMESG000000283.1) HSP 1 Score: 1053.12 bits (2722), Expect = 0.000e+0 Identity = 631/1460 (43.22%), Postives = 920/1460 (63.01%), Query Frame = 3
Query: 315 DSMLFISCGXXXXXXXXXXXXTELRRRGNKSIDVILFVFWWMVFCGYFFRYYSHFIALLQNSKPNRXXXXXXXXXXXXXXXXXXXXDTFLRFPP-----NLRETKHPEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNYGER-EDIFRRASKSEDEEFLINSEEKESFILEH-SGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSV---PLVVTQMSPGASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNE-------SSDKVDKNQNNLIQP-----SAPNKRKRSRLSTSGS---QGFDGN--------------------------------ENAEENYEKYFN----DISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQS-------LLNNSTF-----NQSRNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYI--SENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQFVSSTVIIIAHRLKTIIDCDKIIHLDDGSIIEFGSPKELLSNSSGHFKAL 4469
+ + +S G LS +LF V TE+RRR + ILF+FW+ Y R+YS + +NS N +I+ S L+F++++ +++F R+ N +E PE AS S+LT+ W DS+IY W K +MT++ SF+L S ++S + + F E ++ ++ +KS + L+ ++E +H SG +L + +++A +L+++ D L+L P +LK+LL Y + K TW AF FL G++ S+ ENY + +T+ +S+R+R +IGMI KTLRLS EA+ Y+ G+I+N+ VD E+IM +I +SW + SCPFQII+ VLLY E+ +IF G + + +P+ +M+ +S+ EL WKD+R+ I +EIL GIKVIKMY WE+SF +KI +R E+K I W I+ ++++++P L++ +++ F+ I+AEK F+++ LFN I+ ++++P+G+T+T+ A VS RI ++L+ E+ P L Q+ +IEIQ G FSW R +L NI L++ K KLIAVVG++G GKSSL+SAILGEM T++G V+ +G+IAYV QE WIQN TL+NNIL T+ +N+ FY KV+ +CCL D+E LP D+TEIGERG+NLSGGQKQRVSLARAVYQ+ DIYLLDD LSAVD +V SLF +ISN G+L KTRVL+THGL WLP VDEI V+++ G IS+RG+++ L++ +FK F+ + S + + + ++I+ S N + + SGS FD + E +EEN + + EE+ G V Y K+ G+ +F ++L F LQ F +W+ + + +L N+++ NQ R +FY+ Y I + + V LFW F G + K IH LL ++LR ++FF+ TP GRILNR + D+ ++D + +N+++ + ++++S++VI VTPWF IV IP+ I Y +Q Y+ +SRQ+RRLD+ A+S V ET G SIIR+ + ES F+ + Y IDK+++F+ IQ S+RWLC R+DI+G+L+VF +VI ++ N L+A LVGLSISY+LQVT LNWL RQ E E N V++ERIR+Y+M+P E+ E N+ + ENW + GNI L+Y +L VLKNI +++NGG K+G+VGRTGAGKSSL LALFRL+E +G+I IDG++I++IGLH LR++LTILPQDPVIFSGTL+ NLDPF+ +TD+ L + LE + + DWV+SL EGMNY+CG G NLS GQ+QL+CLAR LL+KSKI+ILDEATASVD ETD+ V+ +K F STVIIIAHR+ TI+D DKI+ LD G ++E GSPK+LL + G FK+L
Sbjct: 23 EGLYLLSYGCLSTALFLVIIQTEIRRRICHPVCPILFIFWFTGSIAYLIRFYSEIVGYSKNSSSNDLIVIQISGALFLLFLLNLFIESFPRYCKLNSMIN-KENPCPEEYASTISKLTFSWFDSYIYKWRKEEMTEENSFELRSNDESKKYINLVEKSFLKKIEFCKEKSKQINKSNSSKNLLTDNDEEFREKKHNSGWILFSCLSKVFLFQLVVAWVLKLIGDTLLLFTPYLLKILLRYVNSENKT-TWISYGIAFTFLANGILSSIMENYSYFMTSYLSVRIRAVIIGMIYSKTLRLSREARNKYTTGEIVNLMSVDAERIMVFIDFSWFIFSCPFQIIIATVLLYQEMNYAIFAGFGLFLVFLPLNGLLMKYAHGFSDVELKWKDERIKIFSEILTGIKVIKMYGWEQSFISKITGLRNLEVKYILRSQIIWGIVYIIWEILPSLIIMVMILSFVFMNRFNFITAEKAFVSLSLFNLIRFSLIIVPYGLTETVNAFVSLKRIAEYLMVEEMEPIGFTYLQNLYEEQLENDPAIEIQGGTFSWKRSDKVILNNINLSIAKGKLIAVVGKIGSGKSSLISAILGEMVTISGDVKIKGRIAYVSQEPWIQNRTLKNNILFTEDYNETFYKKVVVSCCLTQDLEQLPMGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDSHVAHSLFENIISNNGILGGKTRVLITHGLNWLPKVDEIVVLDNSGHISDRGSFKDLLENSLKFKQFIKDHMNPGKNSVNGANFSHESIIEEKVKHHSPENDQLLYEIPDSGSGIETEFDLDYHGPFISKESSPLQFTVVDDADIELHNKIKDLEFSEENNHNLISRSNGQLIDEEQAFVGNVKAKEYFVYVKSRGLLLFLLTVLIYSSFVALQVFSFIWIEKFTEDKVIQNLSNLILKNASYVIDQSNQIRERTEFYMIRYSFICIAMIGVVSLFWVCFAMGTYNSMKYIHGKLLYSILRCPMEFFDTTPVGRILNRLSHDMDLMDRKMPVNLSESFSCFFVVLSSIIVIIYVTPWFAIVIIPLFIFYYFIQFLYMPTSRQSRRLDAIATSPVFNIFTETIQGISIIRACKVESYFQELSYEIIDKNSRFRFIQVSSMRWLCFRIDIIGSLVVFFAVILSITNVSYLTAGLVGLSISYSLQVTEALNWLLRQYTEVEMNMVALERIREYSMVPSEA--EWNSLMPPPENWPNIGNIKFIELDLKYRESLSFVLKNINLDLNGGYKVGIVGRTGAGKSSLTLALFRLMEASNGKIVIDGLDISTIGLHDLRKRLTILPQDPVIFSGTLRENLDPFNVHTDEDLYQCLETAHLQDWVSSLNEGMNYECGEGGVNLSAGQRQLLCLARALLRKSKILILDEATASVDFETDKLVMTTVKEYFRQSTVIIIAHRINTILDTDKIVVLDSGEVVEIGSPKDLLEQADGIFKSL 1478
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000000273.1 (SMESG000000273.1) HSP 1 Score: 971.074 bits (2509), Expect = 0.000e+0 Identity = 544/1241 (43.84%), Postives = 778/1241 (62.69%), Query Frame = 3
Query: 618 PEIIASIFSQLTYKWMDSFIYNWYKVDMTDKTSFDLHSTEKSSINSEISAQYFHNY------GEREDIFRRASKS-----EDEEFLINSEEKESFILEHSGKVLIKSIFGAHFHIILIACLLRIVRDIXXXXXXXXXXXXXNYFKEKQKNYTWKGVLYAFVFLIQGLIGSVFENYCFTLTNKISIRVRGSVIGMISRKTLRLSAEAKATYSAGDIINMTMVDMEQIMNWIVYSWILLSCPFQIILTVVLLYYELGNSIFVGVAMIVTVIPVKIAIMRLTKKYSEKELMWKDKRMNILTEILNGIKVIKMYVWEKSFFNKIESIRQEELKNFRNYSIGWCILNVMFDLVPFLVMYSTFTFYIYFVPFSIISAEKVFIAIVLFNNIQLPMLLLPWGVTQTITAVVSFGRIGKFLLSNEIYPRSSVPLVVTQMSP---GASIEIQNGRFSWTRIGNPVLKNIQLTVEKQKLIAVVGRVGVGKSSLLSAILGEMYTLNGTVQTEGKIAYVPQEAWIQNNTLRNNILCTKSFNKIFYGKVLDACCLEYDIESLPNRDQTEIGERGVNLSGGQKQRVSLARAVYQXXXXXXXXXXXXAVDVNVGQSLFNKLISNQGLLKHKTRVLVTHGLKWLPFVDEICVINDQGQISERGTYEHLMDFGTEFKSFLNE---------------SSDKVDKNQNNLIQ------------------PSAPNKRKRS--------RLSTSGSQGFDG----------------------------------------NENAEENYEKYFNDISHEEEIMSGRVSLNSIVWYFKATGIFVFGSSILACVIFGVLQAFGNVWLGMLADTQSLLNNST---FNQS---------RNSAKFYINCYGIIGLGQLLAVXXXXXXXXXXXXRASKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVLLITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVLNRFSLSASLVGLSISYALQVTGILNWLTRQCAEFETNAVSIERIRQYTMIPVESINETNNYISENWVSNGNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQ 4019
PE+ ASI S+LTY W+D++IY W++ +MTD+TSFDL ++S+ N+ I + F++ +R D+ + ++ S EDE+ L N + + G VL S+ + +L+AC + V D I +P +LK+LL Y + + NY W G A FL G++ S+ EN CF +T+ +SIR+R ++IGMI RKTLRL+ E + +++G+I+N+ VD E+IMNWI+++W LSCP QI+L ++LLY E+ +IF G+ +IV P+ +M L +K+S EL WKD R+ ILTEILNGIKV+KMY WEKSF +KI ++R E++ S + ++ V+++++PFL+M +TF Y+ ++II+ EK F+++ LFN ++ PM++LPWG+T ++ A VS RIG++L+ E+ T S A+IEI++G FSW + L NI + + KL+A+VG+VG GKSSL+SAILGEM+ +NG+V +G IAYV QEAWIQN +L+ NIL T+ +N+ Y +++AC L+ D+E LP D+TEIGERG+NLSGGQKQRVSLARAVYQ+ DIYLLDD LSAVD +VGQ LF +ISN G+LK KTR+LVTHGL WLP VDE+ V++ G ISERG+++ L+ EF F+ E + K +N L Q P+ P +R S RLS+S S+ DG ++N + +K + + EE+ MSG V + K+ G+++F +++ F LQ F N+WL + + N S N S R K+Y+ Y IIGL L V +W F G + ASK IH LL +VLRS ++FF+ TPSGRI+NRF+KD+ +DH + +NI+D ++ ++ S++VI VTPWF I IP+ I Y L+Q+FYI +SRQ+RRLDS A+S V H ET G ++IR+ + + F+++ IDKS+KFK IQ S+RWL LR++ILG L+VF +V+F+++ RFSL+ASLVGLSISY+LQ+T LNWL RQ E ETN V++ERIR+Y+ IP E+ + NN S++W +NGNI +++ L+Y LP VLKNI ++ +GG+KIGVVGRTGAGKSSL LALFRLVE G I ID +NI++IGLH LR++LTILPQ
Sbjct: 25 PEVYASILSKLTYSWLDAYIYKWFRKEMTDETSFDLRRQDESTKNTNILEKIFYDKIKISHNRKRYDLLQNSTASVAHLMEDEDKLTNPDNRSP------GWVLFISLARVYGLELLLACAFKTVHDFSIYAMPFLLKILLEYIQNRSDNY-WIGYFLAIAFLFFGVLSSLAENGCFFITSILSIRIRAALIGMIYRKTLRLNNEIRNKFTSGEIVNLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAFVSLKRIGQYLVGEELNLTEINHREFTDNSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGTIAYVSQEAWIQNKSLKENILFTQDYNEKVYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCNEFMQFVQEYIEHNNNPSGGQHLSDESALGKAKNLLRQLSDNEDVVEEITDFVLTSPAVPIQRNDSHRVSNASDRLSSSISKSIDGFSRHVKYFENSNSGVFEDEDPKSPRIMTPGSQSRQISKETDQNTDRLIDKPISQLVEEEQAMSGTVKWATYSMCIKSRGLWLFIATVAIYAAFTGLQVFSNIWLKNFTEDSDIQNASQHILLNISGSPYWSKIIREQTKYYMVIYTIIGLCMTLVVCFYWASFTVGSINASKVIHKKLLRSVLRSPMEFFDTTPSGRIINRFSKDMENLDHLIPMNISDSLSCLFIVFASIIVIIYVTPWFAIAIIPLAILYYLIQLFYIPTSRQSRRLDSIAASPVFNHFTETLQGVALIRAFKEQQYFQNLNQTLIDKSSKFKFIQQSSVRWLSLRIEILGQLMVFAAVLFSIIGRFSLTASLVGLSISYSLQITEFLNWLLRQYTELETNCVALERIREYSKIPSEAEWDLNNAPSDSWPNNGNITFKDYDLRYREGLPLVLKNINLHFHGGKKIGVVGRTGAGKSSLNLALFRLVEAAGGSITIDKINISTIGLHDLRKRLTILPQ 1258 HSP 2 Score: 89.3521 bits (220), Expect = 1.961e-17 Identity = 116/514 (22.57%), Postives = 223/514 (43.39%), Query Frame = 3
Query: 3030 SKKIHSVLLDTVLRSTLQFFNATPSGRILNRFTKDLFIIDHTLNLNITDIINRTVL----------LITSLVVISIVTPWFGIVGIPILICYILLQVFYISSSRQARRLDSKASSFVLTHLMETYSGSSIIRSLEAESDFESIQYRNIDKSNKFKLIQYLSLRWLCLRLDILGNLIVFGSVIFAVL----NRFSLSASLVGLSISYALQVTGI-LNW-LTRQCAEFETNAVSIERIRQYTMIPVESINETNNY-ISENWVSN--GNINLENFSLQYNINLPCVLKNITININGGEKIGVVGRTGAGKSSLALALFRLVEGCSGRIFIDGVNINSIGLHQLRRQLTILPQDPVIFSGTLKRNLDPFDEYTDDKLLKSLEISGMLDWVNSLTEGMNYDCGNMGTNLSMGQKQLICLARTLLKKSKIIILDEATASVDEETDRRVIEAIKFQ---FVSSTVIIIAHRLKTIIDCDKIIHLD-DGSIIEFGSPKELLSNSSGHFKALAQADEYIKHED 4502
S +I + L+ + R TL+ N I N+FT + + ++++ I+N + ++ +++++ + G+ +++ + L ++ ++ ++ K + L E +G +++ E F D ++ L + +C+ +IL LI+ + + VL N + + V L++ L+ + L W LT F VS++RI QY + ++ E N+ ++N N I + + S + L NI I G+ + +VG+ G GKSSL A+ + +G + + G + + Q+ I + +LK N+ +Y + +E + + L G + G G NLS GQKQ + LAR + + I +LD+ ++VD + + E + T I++ H L + D+++ LD +GSI E GS K+LL + + F Q EYI+H +
Sbjct: 201 SIRIRAALIGMIYRKTLRLNN-----EIRNKFTSGEIV--NLMSVDAERIMNWIIFAWFFLSCPLQIVLAIILLYQEMSYAIFAGLGLIVAFFPLNGLLMNLMQKFSTIELKWKDLRIKILTEILNGIKVLKMYAWEKSFLDKITNLRDTEMRYILRVSAAFGVVCVLWEILPFLIMLATFLCYVLTSEYNIITPEKAFVSLTLFNLLRFPMVVLPWGLTDSMNAF----VSLKRIGQYLVGEELNLTEINHREFTDNSAFNYDAAIEIRDGSFSWKKEDKLTLNNINFEIGRGKLVAIVGKVGTGKSSLISAILGEMHRINGSVSVQGT-------------IAYVSQEAWIQNKSLKENILFTQDYNEKVYEDIIEACSLKSDLEQLPGGDETEIGERGINLSGGQKQRVSLARAVYQNRDIYLLDDPLSAVDAHVGQHLFENVISNNGILKDKTRILVTHGLNWLPKVDEVLVLDSNGSISERGSFKDLLKDCN-EFMQFVQ--EYIEHNN 687 The following BLAST results are available for this feature:
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30024200 ID=SMED30024200|Name=Multidrug resistance-associated protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=4688bpback to top protein sequence of SMED30024200-orf-1 >SMED30024200-orf-1 ID=SMED30024200-orf-1|Name=SMED30024200-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1498bp MNCTLCLCQDSFWSNSHLQSPNYPIFTNCFQYTLLIIGPSIFFITFSILLback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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