cGMP-dependent protein kinase

Overview


Name	cGMP-dependent protein kinase
Smed ID	SMED30024190
Length (bp)	2617

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of cGMP-dependent protein kinase (SMED30024190) t-SNE clustered cells

Violin plots show distribution of expression levels for cGMP-dependent protein kinase (SMED30024190) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of cGMP-dependent protein kinase (SMED30024190) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for cGMP-dependent protein kinase (SMED30024190) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30024190

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
intestinal phagocyte	SMED30024190		Contig5488	GPL15192	PMID:23079596 Forsthoefel et al., 2012
gut	SMED30024190	SMESG000007783.1	dd_Smed_v4_6967_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30024190	SMESG000007783.1	dd_Smed_v4_6967_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30024190	SMESG000007783.1	dd_Smed_v4_6967_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

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Homology

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BLAST of cGMP-dependent protein kinase vs. Ensembl Human
Match: PRKG1 (protein kinase cGMP-dependent 1 [Source:HGNC Symbol;Acc:HGNC:9414])

HSP 1 Score: 621.313 bits (1601), Expect = 0.000e+0
Identity = 323/684 (47.22%), Postives = 446/684 (65.20%), Query Frame = 3

Query:  432 EAENHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRLGISGESSNHQ----RFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKING--DEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESD-IPPDENSGWDKDF 2462
            E    ++L+   + E+D+K+  I++LQ E+DK +SV+            S+     + R+KR  IS E +          TL  +PKS + K +I++AI++N  +  L+ SQ+ EI++CMY     ++  +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+VK L    LW +DR  FQTIMM+TGL +  +   FL+SV  F+ L E  L K+ +++E   Y +G+ IIRQG   D+FFII  G V VT++ +   D + +R +  G++FGEKAL  E  RTAN+ A +  T  L + R +F  LIG L+ +  K Y+D        +  +  +    NLK     L+DF I+ TLG GGFGRVELV    + +K++A+K +KK++IV T+QQ+H+ SEK+I+    S +I RLY TF D+KY+Y+L E CLGGELW ILRDR  F+D  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL YELL G+PPF   DPMK YN+ L+GI+   I    KI   AA+LI++LCR  P ERLGN KNG+++I+ HK+F+GF+WEG++  T+  P  P +  P DTSNFD F  ++D  PPD+NSGWD DF
Sbjct:   17 ELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQAQKQSASTLQG--EPRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFA----NLK-----LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 686

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BLAST of cGMP-dependent protein kinase vs. Ensembl Human
Match: PRKG1 (protein kinase cGMP-dependent 1 [Source:HGNC Symbol;Acc:HGNC:9414])

HSP 1 Score: 616.69 bits (1589), Expect = 0.000e+0
Identity = 322/680 (47.35%), Postives = 441/680 (64.85%), Query Frame = 3

Query:  447 ESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRL-GISGESSNHQRF----QTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKING--DEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESD-IPPDENSGWDKDF 2462
            E  ++  ++ + EK  +I+EL+R++ K +SVL                  I  R+ R  GIS E   ++ F    Q   KF KS   K +I++AI++N  +  L+ SQ+ EI++CMY     ++  +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+VK L    LW +DR  FQTIMM+TGL +  +   FL+SV  F+ L E  L K+ +++E   Y +G+ IIRQG   D+FFII  G V VT++ +   D + +R +  G++FGEKAL  E  RTAN+ A +  T  L + R +F  LIG L+ +  K Y+D        +  +  +    NLK     L+DF I+ TLG GGFGRVELV    + +K++A+K +KK++IV T+QQ+H+ SEK+I+    S +I RLY TF D+KY+Y+L E CLGGELW ILRDR  F+D  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL YELL G+PPF   DPMK YN+ L+GI+   I    KI   AA+LI++LCR  P ERLGN KNG+++I+ HK+F+GF+WEG++  T+  P  P +  P DTSNFD F  ++D  PPD+NSGWD DF
Sbjct:   16 EERIKELEKRLSEKEEEIQELKRKLHKCQSVL------------PVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFA----NLK-----LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 671

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Human
Match: PRKG2 (protein kinase cGMP-dependent 2 [Source:HGNC Symbol;Acc:HGNC:9416])

HSP 1 Score: 612.068 bits (1577), Expect = 0.000e+0
Identity = 318/649 (49.00%), Postives = 418/649 (64.41%), Query Frame = 3

Query:  606 RSKRLGISGESSNHQRFQTLNKFP----------KSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIE--VREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQ--------TKEYDDESR-AKMSLS---MHSRNSAESNNLKRE------SFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            R  + G+S E +   R   LNK P          K +  KK+I  A+  N  L +LDP Q+ +++ECMY ++  +  ++I++GE G  ++V  EG  EV++ EKL+  +     FGELA+LYNC RTASVKA+     W LDR +FQ IM +T   R +  + FL SV+L ++L E KL KI++ +EV+ Y  G  IIR+GEE  +FFI+  G VKVTQ   G +    ++ +  GEYFGEKAL+ +  R+ANI A +     L + R+ F++ +G    LQ            DDE R AK S+S   +    S E   LK +      S    + EI+ATLG GGFGRVELV   K+   ++A+K ++K++IV TKQQ+HV SEK+IL E  S +I +LY TF DNKYVY+L E CLGGELW+ILRDR  FD+  ++FC+ACV EA  YLH  GI+YRDLKPENL++   GYLKL DFGFAKKIG G +TWTFCGTPEYVAPE+ILNK HDFSVDFWS+GIL YELL G PPF   D M  YN+ LKGIE+ +     KIT +   LI+RLCR  P ERLGN KNGI +I+ H++  GF+WEG+K+ ++ SP   ++ GP D S FDK+  E  +PPDE SGWDKDF
Sbjct:  119 RGAKAGVSAEPTT--RTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELV-KVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPR--KITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF 762

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Query:  606 RSKRLGISGESSNHQRFQTLNKFP----------KSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIE--VREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQ--------TKEYDDESR-AKMSLS---MHSRNSAESNNLKRE------SFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            R  + G+S E +   R   LNK P          K +  KK+I  A+  N  L +LDP Q+ +++ECMY ++  +  ++I++GE G  ++V  EG  EV++ EKL+  +     FGELA+LYNC RTASVKA+     W LDR +FQ IM +T   R +  + FL SV+L ++L E KL KI++ +EV+ Y  G  IIR+GEE  +FFI+  G VKVTQ   G +    ++ +  GEYFGEKAL+ +  R+ANI A +     L + R+ F++ +G    LQ            DDE R AK S+S   +    S E   LK +      S    + EI+ATLG GGFGRVELV   K+   ++A+K ++K++IV TKQQ+HV SEK+IL E  S +I +LY TF DNKYVY+L E CLGGELW+ILRDR  FD+  ++FC+ACV EA  YLH  GI+YRDLKPENL++   GYLKL DFGFAKKIG G +TWTFCGTPEYVAPE+ILNK HDFSVDFWS+GIL YELL G PPF   D M  YN+ LKGIE+ +     KIT +   LI+RLCR  P ERLGN KNGI +I+ H++  GF+WEG+K+ ++ SP   ++ GP D S FDK+  E  +PPDE SGWDKDF
Sbjct:  119 RGAKAGVSAEPTT--RTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELV-KVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPR--KITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF 762

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Human
Match: PRKG2 (protein kinase cGMP-dependent 2 [Source:HGNC Symbol;Acc:HGNC:9416])

HSP 1 Score: 583.178 bits (1502), Expect = 0.000e+0
Identity = 304/640 (47.50%), Postives = 401/640 (62.66%), Query Frame = 3

Query:  606 RSKRLGISGESSNHQRFQTLNKFP----------KSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIE--VREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQ--------TKEYDDESR-AKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            R  + G+S E +   R   LNK P          K +  KK+I  A+  N  L +LDP Q+ +++ECMY ++  +  ++I++GE G  ++V  EG  EV++ EKL+  +     FGELA+LYNC RTASVKA+     W LDR +FQ IM +T   R +  + FL SV+L ++L E KL KI++ +EV+ Y  G  IIR+GEE  +FFI+  G VKVTQ   G +    ++ +  GEYFGEKAL+ +  R+ANI A +     L + R+ F++ +G    LQ            DDE R AK S+S    N   S  L  E   L +                  V  K+   ++A+K ++K++IV TKQQ+HV SEK+IL E  S +I +LY TF DNKYVY+L E CLGGELW+ILRDR  FD+  ++FC+ACV EA  YLH  GI+YRDLKPENL++   GYLKL DFGFAKKIG G +TWTFCGTPEYVAPE+ILNK HDFSVDFWS+GIL YELL G PPF   D M  YN+ LKGIE+ +     KIT +   LI+RLCR  P ERLGN KNGI +I+ H++  GF+WEG+K+ ++ SP   ++ GP D S FDK+  E  +PPDE SGWDKDF
Sbjct:  119 RGAKAGVSAEPTT--RTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMS----NWKLSKALSLEMIQLKE-----------------KVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPR--KITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF 733

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BLAST of cGMP-dependent protein kinase vs. Ensembl Celegans
Match: egl-4 (cGMP-dependent protein kinase egl-4 [Source:UniProtKB/Swiss-Prot;Acc:O76360])

HSP 1 Score: 643.269 bits (1658), Expect = 0.000e+0
Identity = 319/698 (45.70%), Postives = 452/698 (64.76%), Query Frame = 3

Query:  441 NHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKA-------------------RSKRLGISGESSNHQ-RFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGD--EIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRE--SFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
              ++++    + I E   ++  LQRE DKL+SVL+Q     +           +                    R+K++ +S E +N + +  TL  + K+   K++IR A+  N  L +L   Q+ E++ CMYE  A    +VI+EGE G++L+V  EGE +V ++  L+GKM      GELA+LYNC RTASV+AL    LWVLDR++FQ I  + G+ER   L  FL  V++F++LSE ++ K+ ++++   Y  G  IIRQGE+ D+FF+I +G VKVTQ+I G+    E+R ++ G++FGE+ALL E  RTANI A     EVL L R++F +LIGDL  L+ K+Y D+ R    +          ++ + E     L + + +ATLG GGFGRVELV  + D  K++ALK +KK++IV T+QQ+H+ +E+ I++E  + +I +LY TF D K+VY+L EVCLGGELW  LRDR HFDDY  RF +ACVLE L YLH + IVYRDLKPEN L+ N+GYLKL DFGFAKK+  G +TWTFCGTPEYV+PEIILNK HD + D+W++GI   EL+ G PPF A+DPMK Y + LKG++   I  N +I   A +L+++LCR  P ERLG+G  G+ +IR H++F GFDWEG++S T+K P  PK++ P D +NFD +  ++D+PPDE SGWD+ F
Sbjct:   54 QQQTIVEGHIKRISELEGEVTTLQRECDKLRSVLEQKAQSAASPGGQPPSPSPRTDQLGNDLQQKAVLPADGVQRAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIEGETEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLESLK-KDYGDKERLAQVVREPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEI-PNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDEGF 749

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Query:  441 NHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKA-------------------RSKRLGISGESSNHQ-RFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGD--EIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRE--SFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
              ++++    + I E   ++  LQRE DKL+SVL+Q     +           +                    R+K++ +S E +N + +  TL  + K+   K++IR A+  N  L +L   Q+ E++ CMYE  A    +VI+EGE G++L+V  EGE +V ++  L+GKM      GELA+LYNC RTASV+AL    LWVLDR++FQ I  + G+ER   L  FL  V++F++LSE ++ K+ ++++   Y  G  IIRQGE+ D+FF+I +G VKVTQ+I G+    E+R ++ G++FGE+ALL E  RTANI A     EVL L R++F +LIGDL  L+ K+Y D+ R    +          ++ + E     L + + +ATLG GGFGRVELV  + D  K++ALK +KK++IV T+QQ+H+ +E+ I++E  + +I +LY TF D K+VY+L EVCLGGELW  LRDR HFDDY  RF +ACVLE L YLH + IVYRDLKPEN L+ N+GYLKL DFGFAKK+  G +TWTFCGTPEYV+PEIILNK HD + D+W++GI   EL+ G PPF A+DPMK Y + LKG++   I  N +I   A +L+++LCR  P ERLG+G  G+ +IR H++F GFDWEG++S T+K P  PK++ P D +NFD +  ++D+PPDE SGWD+ F
Sbjct:   54 QQQTIVEGHIKRISELEGEVTTLQRECDKLRSVLEQKAQSAASPGGQPPSPSPRTDQLGNDLQQKAVLPADGVQRAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIEGETEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLESLK-KDYGDKERLAQVVREPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEI-PNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDEGF 749

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Query:  441 NHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKA-------------------RSKRLGISGESSNHQ-RFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGD--EIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRE--SFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
              ++++    + I E   ++  LQRE DKL+SVL+Q     +           +                    R+K++ +S E +N + +  TL  + K+   K++IR A+  N  L +L   Q+ E++ CMYE  A    +VI+EGE G++L+V  EGE +V ++  L+GKM      GELA+LYNC RTASV+AL    LWVLDR++FQ I  + G+ER   L  FL  V++F++LSE ++ K+ ++++   Y  G  IIRQGE+ D+FF+I +G VKVTQ+I G+    E+R ++ G++FGE+ALL E  RTANI A     EVL L R++F +LIGDL  L+ K+Y D+ R    +          ++ + E     L + + +ATLG GGFGRVELV  + D  K++ALK +KK++IV T+QQ+H+ +E+ I++E  + +I +LY TF D K+VY+L EVCLGGELW  LRDR HFDDY  RF +ACVLE L YLH + IVYRDLKPEN L+ N+GYLKL DFGFAKK+  G +TWTFCGTPEYV+PEIILNK HD + D+W++GI   EL+ G PPF A+DPMK Y + LKG++   I  N +I   A +L+++LCR  P ERLG+G  G+ +IR H++F GFDWEG++S T+K P  PK++ P D +NFD +  ++D+PPDE SGWD+ F
Sbjct:   54 QQQTIVEGHIKRISELEGEVTTLQRECDKLRSVLEQKAQSAASPGGQPPSPSPRTDQLGNDLQQKAVLPADGVQRAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIEGETEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLESLK-KDYGDKERLAQVVREPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEI-PNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDEGF 749

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Query:  441 NHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKA-------------------RSKRLGISGESSNHQ-RFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGD--EIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRE--SFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
              ++++    + I E   ++  LQRE DKL+SVL+Q     +           +                    R+K++ +S E +N + +  TL  + K+   K++IR A+  N  L +L   Q+ E++ CMYE  A    +VI+EGE G++L+V  EGE +V ++  L+GKM      GELA+LYNC RTASV+AL    LWVLDR++FQ I  + G+ER   L  FL  V++F++LSE ++ K+ ++++   Y  G  IIRQGE+ D+FF+I +G VKVTQ+I G+    E+R ++ G++FGE+ALL E  RTANI A     EVL L R++F +LIGDL  L+ K+Y D+ R    +          ++ + E     L + + +ATLG GGFGRVELV  + D  K++ALK +KK++IV T+QQ+H+ +E+ I++E  + +I +LY TF D K+VY+L EVCLGGELW  LRDR HFDDY  RF +ACVLE L YLH + IVYRDLKPEN L+ N+GYLKL DFGFAKK+  G +TWTFCGTPEYV+PEIILNK HD + D+W++GI   EL+ G PPF A+DPMK Y + LKG++   I  N +I   A +L+++LCR  P ERLG+G  G+ +IR H++F GFDWEG++S T+K P  PK++ P D +NFD +  ++D+PPDE SGWD+ F
Sbjct:   42 QQQTIVEGHIKRISELEGEVTTLQRECDKLRSVLEQKAQSAASPGGQPPSPSPRTDQLGNDLQQKAVLPADGVQRAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIEGETEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLESLK-KDYGDKERLAQVVREPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEI-PNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDEGF 737

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Query:  441 NHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKA-------------------RSKRLGISGESSNHQ-RFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGD--EIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRE--SFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
              ++++    + I E   ++  LQRE DKL+SVL+Q     +           +                    R+K++ +S E +N + +  TL  + K+   K++IR A+  N  L +L   Q+ E++ CMYE  A    +VI+EGE G++L+V  EGE +V ++  L+GKM      GELA+LYNC RTASV+AL    LWVLDR++FQ I  + G+ER   L  FL  V++F++LSE ++ K+ ++++   Y  G  IIRQGE+ D+FF+I +G VKVTQ+I G+    E+R ++ G++FGE+ALL E  RTANI A     EVL L R++F +LIGDL  L+ K+Y D+ R    +          ++ + E     L + + +ATLG GGFGRVELV  + D  K++ALK +KK++IV T+QQ+H+ +E+ I++E  + +I +LY TF D K+VY+L EVCLGGELW  LRDR HFDDY  RF +ACVLE L YLH + IVYRDLKPEN L+ N+GYLKL DFGFAKK+  G +TWTFCGTPEYV+PEIILNK HD + D+W++GI   EL+ G PPF A+DPMK Y + LKG++   I  N +I   A +L+++LCR  P ERLG+G  G+ +IR H++F GFDWEG++S T+K P  PK++ P D +NFD +  ++D+PPDE SGWD+ F
Sbjct:   42 QQQTIVEGHIKRISELEGEVTTLQRECDKLRSVLEQKAQSAASPGGQPPSPSPRTDQLGNDLQQKAVLPADGVQRAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIEGETEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLESLK-KDYGDKERLAQVVREPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEI-PNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDEGF 737

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BLAST of cGMP-dependent protein kinase vs. Ensembl Fly
Match: Pkg21D (gene:FBgn0000442 transcript:FBtr0078042)

HSP 1 Score: 625.935 bits (1613), Expect = 0.000e+0
Identity = 319/634 (50.32%), Postives = 421/634 (66.40%), Query Frame = 3

Query:  597 IKARSKRLGISGESSNHQRFQT----LNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKAL-KTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKI---NGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRA-KMSLSMHSRNSAESNNLKRE--SFHLNDFEIVATLGFGGFGRVELV-VNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            + A  K+ G+S ES      Q+    + K+ K    K+ I+ AIM+N  L  +D SQV E+++ MY K      FVIREGE G  LYV+  GEF V +  K++ KM   K FGELA+LYNC RTAS++ L +   +WVLDR +FQ IMM TGL+R ++   FL SV L  +LSE  L KI +++E++ Y+ G  IIRQG   DSFF+I  G V+VTQK+   + +E E+R +S G+YFGE+AL+ E KRTANI A+    E L L R +F  LIGDL  L+ K+Y DESR   M  +  S        L++E     L D E+V+TLG GGFGRVELV  + +D    +ALK +KK++IV TKQ++H+ SE+ I+L  +S +ICRLY TF D KYVY+L E C+GGE+W +LRDR  F+D   +F + CVL+A  YLH+RGI+YRDLKPENL++   GY+K+ DFGFAK+IG   +TWTFCGTPEYVAPEIILNK HD +VD+W++GIL +ELLNG PPF A DPM+ YN+ LKGI+   I     I+  A  LI+RLCR +P ERLG    GI++I+ HK+F GFDW+G+ S  +  PF   I  P D   FD+F  + + PPDE SGWD DF
Sbjct:  137 MPAAIKKQGVSAESCVQSMQQSYSIPIPKYEKDFSDKQQIKDAIMDNDFLKNIDASQVRELVDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVLDKMGAGKAFGELAILYNCTRTASIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAKIADVLELEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALINEDKRTANIIALSPGVECLTLDRDSFKRLIGDLCELKEKDYGDESRKLAMKQAQESCRDEPKEQLQQEFPDLKLTDLEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDM--IAFPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTDVRYFDRFPCDLNEPPDELSGWDADF 768

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BLAST of cGMP-dependent protein kinase vs. Ensembl Fly
Match: for (gene:FBgn0000721 transcript:FBtr0089310)

HSP 1 Score: 570.466 bits (1469), Expect = 0.000e+0
Identity = 292/628 (46.50%), Postives = 410/628 (65.29%), Query Frame = 3

Query:  606 RSKRLGISGESSNHQRF----QTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVT--QKINGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLY--RQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDEN-SGWDKDF 2462
            R + LGIS E  +         +  K+ K    +++I+ AI++N  +  LD +Q+ EI++CMY         +I+EG+ G  +YV ++G  EV ++ K +  +S  K  GELA+LYNC+RTA++ A+  C LW ++R  FQTIMM+TGL RQ +   FL+SV +F+ L+E  L+KI +++E   Y  G  I+RQG   D+FFII  G V+VT  Q+   +E  +R +  G++FGEKAL  +  RTANI   +    V CL   R+ F++LI +L+ ++ + YDDE       +M  R   E    +    +L D  ++ATLG GGFGRVELV  + D ++S+ALK MKK  IV+T+QQ H+MSEK+I+ E    +I +L+ TF D KY+Y+L E CLGGELW ILRD+ +FDD  TRF  ACV+EA  YLHSR I+YRDLKPENLL+   GY+KL DFGFAKK+  G +TWTFCGTPEYVAPE+ILN+ HD S D+WS+G+L +ELL G PPF  +DPM+ YN+ LKGI+      N  IT  A++LI++LCR  P ERLG  + GI EI+ HK+F GF W G+++ T++ P  P +    DT+NFD +  + + PP ++ +GWDKDF
Sbjct:  475 RQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIIC-ESADGVSCLVIDRETFNQLISNLDEIKHR-YDDEG------AMERRKINE----EFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRN--ITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 1088

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Fly
Match: for (gene:FBgn0000721 transcript:FBtr0089312)

HSP 1 Score: 570.466 bits (1469), Expect = 0.000e+0
Identity = 292/628 (46.50%), Postives = 410/628 (65.29%), Query Frame = 3

Query:  606 RSKRLGISGESSNHQRF----QTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVT--QKINGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLY--RQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDEN-SGWDKDF 2462
            R + LGIS E  +         +  K+ K    +++I+ AI++N  +  LD +Q+ EI++CMY         +I+EG+ G  +YV ++G  EV ++ K +  +S  K  GELA+LYNC+RTA++ A+  C LW ++R  FQTIMM+TGL RQ +   FL+SV +F+ L+E  L+KI +++E   Y  G  I+RQG   D+FFII  G V+VT  Q+   +E  +R +  G++FGEKAL  +  RTANI   +    V CL   R+ F++LI +L+ ++ + YDDE       +M  R   E    +    +L D  ++ATLG GGFGRVELV  + D ++S+ALK MKK  IV+T+QQ H+MSEK+I+ E    +I +L+ TF D KY+Y+L E CLGGELW ILRD+ +FDD  TRF  ACV+EA  YLHSR I+YRDLKPENLL+   GY+KL DFGFAKK+  G +TWTFCGTPEYVAPE+ILN+ HD S D+WS+G+L +ELL G PPF  +DPM+ YN+ LKGI+      N  IT  A++LI++LCR  P ERLG  + GI EI+ HK+F GF W G+++ T++ P  P +    DT+NFD +  + + PP ++ +GWDKDF
Sbjct:  475 RQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIIC-ESADGVSCLVIDRETFNQLISNLDEIKHR-YDDEG------AMERRKINE----EFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRN--ITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 1088

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Fly
Match: for (gene:FBgn0000721 transcript:FBtr0089304)

HSP 1 Score: 570.466 bits (1469), Expect = 0.000e+0
Identity = 292/628 (46.50%), Postives = 410/628 (65.29%), Query Frame = 3

Query:  606 RSKRLGISGESSNHQRF----QTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVT--QKINGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLY--RQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDEN-SGWDKDF 2462
            R + LGIS E  +         +  K+ K    +++I+ AI++N  +  LD +Q+ EI++CMY         +I+EG+ G  +YV ++G  EV ++ K +  +S  K  GELA+LYNC+RTA++ A+  C LW ++R  FQTIMM+TGL RQ +   FL+SV +F+ L+E  L+KI +++E   Y  G  I+RQG   D+FFII  G V+VT  Q+   +E  +R +  G++FGEKAL  +  RTANI   +    V CL   R+ F++LI +L+ ++ + YDDE       +M  R   E    +    +L D  ++ATLG GGFGRVELV  + D ++S+ALK MKK  IV+T+QQ H+MSEK+I+ E    +I +L+ TF D KY+Y+L E CLGGELW ILRD+ +FDD  TRF  ACV+EA  YLHSR I+YRDLKPENLL+   GY+KL DFGFAKK+  G +TWTFCGTPEYVAPE+ILN+ HD S D+WS+G+L +ELL G PPF  +DPM+ YN+ LKGI+      N  IT  A++LI++LCR  P ERLG  + GI EI+ HK+F GF W G+++ T++ P  P +    DT+NFD +  + + PP ++ +GWDKDF
Sbjct:  475 RQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIIC-ESADGVSCLVIDRETFNQLISNLDEIKHR-YDDEG------AMERRKINE----EFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRN--ITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 1088

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Fly
Match: for (gene:FBgn0000721 transcript:FBtr0446099)

HSP 1 Score: 569.311 bits (1466), Expect = 0.000e+0
Identity = 292/628 (46.50%), Postives = 410/628 (65.29%), Query Frame = 3

Query:  606 RSKRLGISGESSNHQRF----QTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVT--QKINGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLY--RQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDEN-SGWDKDF 2462
            R + LGIS E  +         +  K+ K    +++I+ AI++N  +  LD +Q+ EI++CMY         +I+EG+ G  +YV ++G  EV ++ K +  +S  K  GELA+LYNC+RTA++ A+  C LW ++R  FQTIMM+TGL RQ +   FL+SV +F+ L+E  L+KI +++E   Y  G  I+RQG   D+FFII  G V+VT  Q+   +E  +R +  G++FGEKAL  +  RTANI   +    V CL   R+ F++LI +L+ ++ + YDDE       +M  R   E    +    +L D  ++ATLG GGFGRVELV  + D ++S+ALK MKK  IV+T+QQ H+MSEK+I+ E    +I +L+ TF D KY+Y+L E CLGGELW ILRD+ +FDD  TRF  ACV+EA  YLHSR I+YRDLKPENLL+   GY+KL DFGFAKK+  G +TWTFCGTPEYVAPE+ILN+ HD S D+WS+G+L +ELL G PPF  +DPM+ YN+ LKGI+      N  IT  A++LI++LCR  P ERLG  + GI EI+ HK+F GF W G+++ T++ P  P +    DT+NFD +  + + PP ++ +GWDKDF
Sbjct:  129 RQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIIC-ESADGVSCLVIDRETFNQLISNLDEIKHR-YDDEG------AMERRKINE----EFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRN--ITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 742

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Zebrafish
Match: prkg1b (protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:ZDB-GENE-080225-40])

HSP 1 Score: 635.18 bits (1637), Expect = 0.000e+0
Identity = 326/684 (47.66%), Postives = 446/684 (65.20%), Query Frame = 3

Query:  432 EAENHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRLGISGESSNHQ----RFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQK--INGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINES-DIPPDENSGWDKDF 2462
            E    ++L+   + E+D+K+  I++LQ E+DK +SV+      +              R+KR  IS E +          TL  +PKS + K++I++AI++N  +  L+ SQ+ EI++CMY     +   +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+V+ L    LW +DR  FQTIMM+TGL +  +   FL+SV  F+ L E  L K+ +++E   YSDG+ IIRQG   D+FFII  G V VT++   NG  + +R +  G++FGEKAL  E  RTAN+ A +  T  L + R++F  LIG L+ +  K YDD           ++   E+ N    +  L DF I+ TLG GGFGRVELV    + TK++A+K +KK++IV T+QQ+H+ SEK+I+ E  S +I RLY TF D+KY+Y+L E CLGGELW ILRDR  F+D  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL YELL G+PPF   DPMK YN+ L+GI+   I    KIT  A +LI++LCR  P ERLGN KNG+++I+ HK+F+GF+WEG++  T+  P  P +  P DTSNFD F  ++ D PPD+NSGWD DF
Sbjct:   17 ELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQVHKQSALQE----HQRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKELIKEAILDNDFMKNLELSQIQEIVDCMYPVEYDKESCIIKEGDVGSLVYVMEDGKVEVTKEGMKLCTMGPGKVFGELAILYNCTRTATVQTLTNVKLWAIDRQCFQTIMMRTGLIKHAEYMEFLKSVPTFQGLQEEILSKLADVLEETHYSDGEYIIRQGARGDTFFIISKGKVNVTREDAPNGTPVYLRALGKGDWFGEKALQGEDIRTANVIAAEAVT-CLVIDRESFKHLIGGLDDVSNKGYDDAG---------AKAKYEAENAFFSNLKLVDFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKQIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKITKNAGNLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLIPPIIPDVASPTDTSNFDSFPEDNEDPPPDDNSGWDTDF 684

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Zebrafish
Match: prkg1b (protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:ZDB-GENE-080225-40])

HSP 1 Score: 628.632 bits (1620), Expect = 0.000e+0
Identity = 326/681 (47.87%), Postives = 442/681 (64.90%), Query Frame = 3

Query:  447 ESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRL-GISGESSNHQRFQ-----TLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQK--INGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINES-DIPPDENSGWDKDF 2462
            E  ++  +R +  K  ++ EL+R++ K +SVL  T               I  R++R  GIS E    + FQ      L K  KS   K++I++AI++N  +  L+ SQ+ EI++CMY     +   +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+V+ L    LW +DR  FQTIMM+TGL +  +   FL+SV  F+ L E  L K+ +++E   YSDG+ IIRQG   D+FFII  G V VT++   NG  + +R +  G++FGEKAL  E  RTAN+ A +  T  L + R++F  LIG L+ +  K YDD           ++   E+ N    +  L DF I+ TLG GGFGRVELV    + TK++A+K +KK++IV T+QQ+H+ SEK+I+ E  S +I RLY TF D+KY+Y+L E CLGGELW ILRDR  F+D  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL YELL G+PPF   DPMK YN+ L+GI+   I    KIT  A +LI++LCR  P ERLGN KNG+++I+ HK+F+GF+WEG++  T+  P  P +  P DTSNFD F  ++ D PPD+NSGWD DF
Sbjct:   16 EERIKEMERLLSAKEQEVNELKRKLHKYQSVLPST---------------IGPRTRRAQGISAEPQTARSFQDLKSEALRKHHKSVRSKELIKEAILDNDFMKNLELSQIQEIVDCMYPVEYDKESCIIKEGDVGSLVYVMEDGKVEVTKEGMKLCTMGPGKVFGELAILYNCTRTATVQTLTNVKLWAIDRQCFQTIMMRTGLIKHAEYMEFLKSVPTFQGLQEEILSKLADVLEETHYSDGEYIIRQGARGDTFFIISKGKVNVTREDAPNGTPVYLRALGKGDWFGEKALQGEDIRTANVIAAEAVT-CLVIDRESFKHLIGGLDDVSNKGYDDAG---------AKAKYEAENAFFSNLKLVDFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKQIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKITKNAGNLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLIPPIIPDVASPTDTSNFDSFPEDNEDPPPDDNSGWDTDF 669

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Zebrafish
Match: prkg1a (protein kinase cGMP-dependent 1a [Source:ZFIN;Acc:ZDB-GENE-040426-1308])

HSP 1 Score: 613.224 bits (1580), Expect = 0.000e+0
Identity = 324/679 (47.72%), Postives = 438/679 (64.51%), Query Frame = 3

Query:  447 ESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRL-GISGESSNHQRF--QTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQK-INGDE-IEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDD-ESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINES-DIPPDENSGWDKDF 2462
            E  +R  +R + E+  +I EL+R++ K +SVL                  I  R+ R  GIS E   HQ    Q+  +  KS+  K +I+ AI++N  +  L+ SQ+ EI++CMY     +N  +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+V+ + +  LW +DR  FQTIMM+TGL +  +    L+SV  F  L E  L K+ +++E   Y DG  IIRQG   D+FFII  G V +T++   G E + +R M  G+ FGEKAL  E  RTAN+ A +  T  L + R ++  LIG L  +  K  +D E++AK           E+ N    + +L+DF I+ TLG GGFGRVELV    D  K++A+K +KK++IV T+QQ+H+ SEK I+ E  S +I RLY TF D+KY+Y+L E CLGGELW ILRDR +FDD  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL YELL G+PPF   DPMK YN+ L+GI+   I    KIT  AA+LI++LCR  P ERLGN KNG+++I+ HK+F+GF+W+G++  T+  P  P +    DTSNFD F  ++ D PPD+NSGWD DF
Sbjct:   16 EERIRDLERRLLEREDEISELKRKLHKCQSVLPSAQ--------------IGPRTHRAQGISAEPQTHQDLSNQSFRRVAKSDRSKDLIKSAILDNDFMKNLEMSQIQEIVDCMYPVDYDKNSCIIKEGDVGSLVYVMEDGKVEVTKEGLKLCTMGPGKVFGELAILYNCTRTATVRTVSSVKLWAIDRQCFQTIMMRTGLIKHAEYMELLKSVLTFRGLPEEILSKLADVLEETHYEDGNYIIRQGARGDTFFIISKGKVTMTREDCPGQEPVYLRSMGRGDSFGEKALQGEDIRTANVIAAETVT-CLVIDRDSYKHLIGGLEDVSNKGCEDAEAKAKY----------EAENAFFSNLNLSDFNIIDTLGVGGFGRVELVQLKSDEMKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGNFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKITKNAANLIKKLCRDTPSERLGNLKNGVKDIQKHKWFEGFNWDGLRKGTLMPPIIPNVTSSTDTSNFDSFPEDNEDPPPDDNSGWDIDF 667

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BLAST of cGMP-dependent protein kinase vs. Ensembl Zebrafish
Match: prkg1b (protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:ZDB-GENE-080225-40])

HSP 1 Score: 577.785 bits (1488), Expect = 0.000e+0
Identity = 311/681 (45.67%), Postives = 420/681 (61.67%), Query Frame = 3

Query:  447 ESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRL-GISGESSNHQRFQ-----TLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQK--INGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINES-DIPPDENSGWDKDF 2462
            E  ++  +R +  K  ++ EL+R++ K +SVL  T               I  R++R  GIS E    + FQ      L K  KS   K++I++AI++N  +  L+ SQ+ EI++CMY     +   +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+V+ L    LW +DR               + L  F+       H S               YSDG+ IIRQG   D+FFII  G V VT++   NG  + +R +  G++FGEKAL  E  RTAN+ A +  T  L + R++F  LIG L+ +  K YDD           ++   E+ N    +  L DF I+ TLG GGFGRVELV    + TK++A+K +KK++IV T+QQ+H+ SEK+I+ E  S +I RLY TF D+KY+Y+L E CLGGELW ILRDR  F+D  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL YELL G+PPF   DPMK YN+ L+GI+   I    KIT  A +LI++LCR  P ERLGN KNG+++I+ HK+F+GF+WEG++  T+  P  P +  P DTSNFD F  ++ D PPD+NSGWD DF
Sbjct:   16 EERIKEMERLLSAKEQEVNELKRKLHKYQSVLPST---------------IGPRTRRAQGISAEPQTARSFQDLKSEALRKHHKSVRSKELIKEAILDNDFMKNLELSQIQEIVDCMYPVEYDKESCIIKEGDVGSLVYVMEDGKVEVTKEGMKLCTMGPGKVFGELAILYNCTRTATVQTLTNVKLWAIDR---------------QSLTAFISI-----HSSP---------TPDTHYSDGEYIIRQGARGDTFFIISKGKVNVTREDAPNGTPVYLRALGKGDWFGEKALQGEDIRTANVIAAEAVT-CLVIDRESFKHLIGGLDDVSNKGYDDAG---------AKAKYEAENAFFSNLKLVDFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKQIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKITKNAGNLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLIPPIIPDVASPTDTSNFDSFPEDNEDPPPDDNSGWDTDF 640

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BLAST of cGMP-dependent protein kinase vs. Ensembl Zebrafish
Match: prkg2 (protein kinase cGMP-dependent 2 [Source:ZFIN;Acc:ZDB-GENE-060531-80])

HSP 1 Score: 557.37 bits (1435), Expect = 0.000e+0
Identity = 291/615 (47.32%), Postives = 397/615 (64.55%), Query Frame = 3

Query:  678 KSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIE--VREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQ--------TKEYDDESR-AKMSLSMHSRNSAESNNL----KRES-----FHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            K   VKK++  A+  N  L +L+  QV +++ECMYE+   +  +VI++GE G  L+V  +G+ +VY+  KL+  ++    FGELA+LYNC RTASVKA      W LDR +F  IM  T   R +  + FL SV+L   L   KL KIV+ +EV+ Y+ G  IIR+GEE ++F+II  G +KVTQ     E    +  +  G+YFGEKAL+ +  R+ANI A +   E L + R+ FS+ +G  + L+        +   DD+ R AK S S    N+  S+++    +RES           E +ATLG GGFGRVELV   K+   ++ALK +KK++IV  +Q++H+ SE++ILLE    +I ++Y T+ DNKYVY+L E CLGGE+W++LRDR  F++Y  +FC+ CV EA  YLH+ GI+YRDLKPENL++   GY+KL DFGFAKK+  G RTWTFCGTPEYVAPEIILNK H  SVDFWS+GIL +ELL G+PPF  +D M IY   LKGIE+ +     KIT +   LI++LCR  P ERLGN KNGI +I+ H++F GF W G+K+  + SP   ++ GP D S FD +  E +IPPDE SGWD DF
Sbjct:  158 KEQSVKKLLTDALNKNQYLRRLEVQQVKDMVECMYERTYQQGEYVIKQGEPGNHLFVLADGKLDVYQHNKLLTSIAVWTTFGELAILYNCTRTASVKAASNVKTWALDREVFHNIMRMTAEARHEQYRNFLRSVSLLASLPGDKLTKIVDCLEVEYYNKGDYIIREGEEGNTFYIIANGKIKVTQSTQDHEEPQIINTLGKGDYFGEKALISDDVRSANIIAEEDGVECLVIDRETFSQTVGTFDELKKYLQSYVDSLARDDKKRNAKRSGSCTPPNTPVSHDMIELKERESSFASTIPFTCLEAIATLGVGGFGRVELV-KLKNENVTFALKCIKKRHIVDNRQEEHIYSERRILLETNCPFIVKMYRTYKDNKYVYMLLEACLGGEIWSLLRDRGSFEEYTAKFCVGCVTEAFDYLHNNGIIYRDLKPENLMLDTDGYVKLVDFGFAKKLKCGQRTWTFCGTPEYVAPEIILNKGHGLSVDFWSLGILIFELLTGSPPFTGSDQMIIYTFILKGIEKMDFPK--KITKRPGDLIRKLCRQNPSERLGNLKNGITDIKKHRWFTGFSWSGLKARNLISPLKREVKGPTDHSYFDSYPPEEEIPPDEMSGWDTDF 769

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BLAST of cGMP-dependent protein kinase vs. Ensembl Xenopus
Match: camk4 (calcium/calmodulin-dependent protein kinase IV [Source:Xenbase;Acc:XB-GENE-5911781])

HSP 1 Score: 624.009 bits (1608), Expect = 0.000e+0
Identity = 325/684 (47.51%), Postives = 444/684 (64.91%), Query Frame = 3

Query:  432 EAENHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRLGISGESS----NHQRFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKING--DEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINES-DIPPDENSGWDKDF 2462
            E    ++L+   + E+D+K+  I+ LQ E+DK +SV+      +   + ++     + R+KR  IS E +          TL  +PKS + K++I++AI++N  +  L+ SQ+ EI++CMY     ++  +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+VK L    LW +DR  FQTIMM+TGL +  +   FL+SV  F+ L E  + K+ +++E   Y  G  IIRQG   D+FFII  G V VT++ +   D I +R +  G++FGEKAL  E  RTAN+ A +  T  L + R +F  LIG L+ +  K Y+D        +  +       NLK     L DF I+ TLG GGFGRVELV    D  K++A+K +KK++IV T+QQ+H+ SEK+I+    S +I RLY TF D+KY+Y+L E CLGGELW ILRDR  FDD  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL YELL G+PPF   DPMK YN+ L+GI+   I    KIT  AA+LI++LCR  P ERLGN KNG+++I+ HK+F+GF+WEG++  T+  P  P +  P DTSNFD F  ++ D PPD+NSGWD DF
Sbjct:   17 ELRQRDALIDELELELDQKDELIQRLQNELDKYRSVIKPATQQVHKQNPTTLG---EQRTKRQAISAEPTAIDIQELSHVTLPFYPKSPQSKELIKEAILDNDFMKNLEISQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKESVKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTREDSPGEDPIFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAF----FGNLK-----LADFNIIDTLGVGGFGRVELVQLKSDECKTFAMKILKKRHIVDTRQQEHIRSEKQIMQSAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNEDPPPDDNSGWDIDF 685

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Query:  432 EAENHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRLGISGESS----NHQRFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKING--DEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINES-DIPPDENSGWDKDF 2462
            E    ++L+   + E+D+K+  I+ LQ E+DK +SV+      +   + ++     + R+KR  IS E +          TL  +PKS + K++I++AI++N  +  L+ SQ+ EI++CMY     ++  +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+VK L    LW +DR  FQTIMM+TGL +  +   FL+SV  F+ L E  + K+ +++E   Y  G  IIRQG   D+FFII  G V VT++ +   D I +R +  G++FGEKAL  E  RTAN+ A +  T  L + R +F  LIG L+ +  K Y+D        +  +       NLK     L DF I+ TLG GGFGRVELV    D  K++A+K +KK++IV T+QQ+H+ SEK+I+    S +I RLY TF D+KY+Y+L E CLGGELW ILRDR  FDD  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL YELL G+PPF   DPMK YN+ L+GI+   I    KIT  AA+LI++LCR  P ERLGN KNG+++I+ HK+F+GF+WEG++  T+  P  P +  P DTSNFD F  ++ D PPD+NSGWD DF
Sbjct:   17 ELRQRDALIDELELELDQKDELIQRLQNELDKYRSVIKPATQQVHKQNPTTLG---EQRTKRQAISAEPTAIDIQELSHVTLPFYPKSPQSKELIKEAILDNDFMKNLEISQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKESVKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTREDSPGEDPIFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAF----FGNLK-----LADFNIIDTLGVGGFGRVELVQLKSDECKTFAMKILKKRHIVDTRQQEHIRSEKQIMQSAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNEDPPPDDNSGWDIDF 685

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BLAST of cGMP-dependent protein kinase vs. Ensembl Xenopus
Match: camk4 (calcium/calmodulin-dependent protein kinase IV [Source:Xenbase;Acc:XB-GENE-5911781])

HSP 1 Score: 619.002 bits (1595), Expect = 0.000e+0
Identity = 326/681 (47.87%), Postives = 439/681 (64.46%), Query Frame = 3

Query:  447 ESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRL-GISGESSNHQRF-----QTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKING--DEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINES-DIPPDENSGWDKDF 2462
            E  +R  +  + EK  +I+EL+R++ K +SVL              S + I  R+ R  GIS E  + + +     Q   KF KS   K++I++AI++N  +  L+ SQ+ EI++CMY     ++  +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+VK L    LW +DR  FQTIMM+TGL +  +   FL+SV  F+ L E  + K+ +++E   Y  G  IIRQG   D+FFII  G V VT++ +   D I +R +  G++FGEKAL  E  RTAN+ A +  T  L + R +F  LIG L+ +  K Y+D        +  +       NLK     L DF I+ TLG GGFGRVELV    D  K++A+K +KK++IV T+QQ+H+ SEK+I+    S +I RLY TF D+KY+Y+L E CLGGELW ILRDR  FDD  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL YELL G+PPF   DPMK YN+ L+GI+   I    KIT  AA+LI++LCR  P ERLGN KNG+++I+ HK+F+GF+WEG++  T+  P  P +  P DTSNFD F  ++ D PPD+NSGWD DF
Sbjct:   16 EERIRDLENRLSEKEKEIQELKRKLHKYQSVL-----------AMPSTSHIGPRTTRAQGISAEPQSFRSYHDLTRQAFKKFTKSERSKELIKEAILDNDFMKNLEISQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKESVKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTREDSPGEDPIFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAF----FGNLK-----LADFNIIDTLGVGGFGRVELVQLKSDECKTFAMKILKKRHIVDTRQQEHIRSEKQIMQSAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNEDPPPDDNSGWDIDF 673

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Xenopus
Match: tnpo2 (transportin 2 [Source:Xenbase;Acc:XB-GENE-968452])

HSP 1 Score: 598.586 bits (1542), Expect = 0.000e+0
Identity = 323/699 (46.21%), Postives = 443/699 (63.38%), Query Frame = 3

Query:  471 REIDEKNLKIEELQRE-------IDKLKSVL--DQTXXXXXXXXXXXXXXXIKARSKRLGISGESSNHQRFQTLNKFP------KSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLES-VNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDE--IEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQT--KEY------DDESRAKMSLSMH---SRNSAESNNLKR------ESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            +E+ EK+ KI +L++E       IDKL+  L  + T +          L+  + +  + G+S E ++   +   ++ P      K +  KK+I  AIM+N  L +L+ S V  +++CMYE+   ++  VI+EG  G  LYV  +G  +V ++ +L+G+M     FGELA+LYNCKRTA+VKA+    +WVLDR +FQ IMM +   + ++  +FL   V LF  +  R L  I        Y  G  IIR+GEE ++FFII  G V VTQ + G +   E++ +  G+YFGEKAL+ E  R+ANI A +  T+ L + R  F++++G    LQT  +EY      +D  R     S+H   SR+++E N L+        +      +++ TLG GGFGRVELV   KD   ++ALK +KK++IV T QQ+HV  EK IL +   S+I RLY TF D KYVY+L EVCLGGELW+ILRD   F++   RFC  CVLEA  YLH+RGIVYRDLKPENLL+ + GY+K+ DFGFAKKIG G +TWTFCGTPEYVAPEII+N+ HDF  D+WS+GIL YELL G+PPF   DP+KIYNM LKGIE+ +  H  +I  ++  +I+RLCR  P ERLGN KNGI +IR HK+FQGF+WEG+++  + SP   +I G  D S FD F+ ES+ PPDE SGWDK+F
Sbjct:   53 KELQEKDEKILQLEKELEVKVIQIDKLQDALGYNVTQTSPKGSQKKKLLSAHRRQKAKEGVSAEPTSRHYYNPSSQNPDVTCVRKDSSAKKLITGAIMSNDFLRQLEASHVRCMVDCMYERVYSKSQLVIQEGAAGNHLYVLADGLLDVIQNSRLLGQMHPGTAFGELAILYNCKRTATVKAVTDSKIWVLDRQVFQNIMMSSAQAQHQEYFSFLRRYVGLFSVMIYRLLYTIKN---TDFYDKGDYIIREGEEGNTFFIIAKGKVCVTQAVEGSQEPQEIKTLGVGDYFGEKALISEDVRSANIIAEEDDTQCLVIDRDTFNQMVGTYQELQTYLREYVFQLALNDHDRRNARKSLHHSMSRDNSEVNQLRELVSKFSSTSPFRYLDVITTLGTGGFGRVELV-KLKDEDMTFALKCIKKKHIVDTHQQEHVYWEKNILQQINCSFIIRLYRTFRDAKYVYMLLEVCLGGELWSILRDTGPFEEGTARFCTGCVLEAFDYLHNRGIVYRDLKPENLLLDSEGYIKMVDFGFAKKIGPGKKTWTFCGTPEYVAPEIIMNRGHDFGADYWSLGILIYELLTGSPPFSGTDPIKIYNMVLKGIEKVDFPH--RIGRRSEDVIRRLCRINPAERLGNRKNGISDIRKHKWFQGFNWEGLRNRKLLSPLKREIKGITDHSYFDNFLPESEEPPDELSGWDKNF 745

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Xenopus
Match: ptafr (platelet activating factor receptor [Source:Xenbase;Acc:XB-GENE-968925])

HSP 1 Score: 586.645 bits (1511), Expect = 0.000e+0
Identity = 302/654 (46.18%), Postives = 411/654 (62.84%), Query Frame = 3

Query:  600 KARSKRLGISGESS------NHQRFQTLNKFPKSNEVKKV-IRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKING--DEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQ--------TKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLN----------------DFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            K +  + G+S E +      +H RF       + N  +K+ I  A+  N  + ++D  Q+ +++ECMYE+  ++  F+IR+GE G Q++V  +G+ EV+++ KL+  +     FGELA+LYNC RTASVKA+     W LDR +FQ IM KT   + ++  +FL+SV L + L E KL+KI + +E++ Y     IIR+GEE  +FFII  G VKVTQ   G  +   ++ +  G+YFGEKAL+ +  R+ANI A     E L + R+ F++ +G    L             DDE R       H+++     +L+  S  LN                + EIV TLG GGFGRVELV   K+    +ALK +KK++IV  +QQ+H+ SEK IL E  S +I +LY TF DNKYVY+L E CLGGELW+ILRDR  FD+   +FC  CV EA  YLH +G++YRDLKPENLL+ + GY+KL DFGFAKKI  G +TWTFCGTPEYVAPE+ILNK H FSVDFWS+GIL YELL G+PPF   D M IYN+ L+GIE+     N  IT +   LI+RLCR  P ERLGN KNGI +I+ H++F GF+WEG+ + ++ SP  P++ GP D S FD +  + +IPPDE SGWD+DF
Sbjct:  144 KRKGAKEGVSAEPTSRYDGGDHPRFSFEKARVRKNTSEKILISDALNKNQFMKRMDHHQIQDMVECMYERIYLQGEFIIRQGEPGSQIFVLADGKAEVFQENKLLTSIPVWTTFGELAILYNCTRTASVKAITGVRTWALDREVFQNIMRKTAQSKHEEYLSFLKSVPLLKELPEHKLMKIADCLELEFYEMDDYIIREGEEGSTFFIISKGKVKVTQSTEGYKEPQYIKFLEKGDYFGEKALISDDVRSANILAYGDRVECLVMDRETFNKTVGTYEELMKCLEGYVANLTLDDERR-------HAKSPVNERHLRAVSMELNKMKQTLARFPSASPFENLEIVTTLGVGGFGRVELV-KVKNENLVFALKCIKKRHIVDNRQQEHIHSEKNILEEACSPFIVKLYCTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTAKFCTGCVTEAFEYLHQKGVLYRDLKPENLLLDSEGYVKLVDFGFAKKIFPGQKTWTFCGTPEYVAPEVILNKGHSFSVDFWSLGILLYELLTGSPPFTGPDQMIIYNLILQGIEKIEFYKN--ITKRPEDLIRRLCRENPAERLGNMKNGIADIKKHRWFNGFNWEGLNTRSLPSPLKPELEGPTDHSYFDSYPPDEEIPPDEVSGWDQDF 787

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Mouse
Match: Prkg1 (protein kinase, cGMP-dependent, type I [Source:MGI Symbol;Acc:MGI:108174])

HSP 1 Score: 622.468 bits (1604), Expect = 0.000e+0
Identity = 323/684 (47.22%), Postives = 446/684 (65.20%), Query Frame = 3

Query:  432 EAENHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRLGISGESSNHQ----RFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKING--DEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESD-IPPDENSGWDKDF 2462
            E    ++L+   + E+D+K+  I++LQ E+DK +SV+            S+     + R+KR  IS E +          TL  +PKS + K +I++AI++N  +  L+ SQ+ EI++CMY     ++  +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+VK L    LW +DR  FQTIMM+TGL +  +   FL+SV  F+ L +  L K+ +++E   Y +G+ IIRQG   D+FFII  G V VT++ +   D + +R +  G++FGEKAL  E  RTAN+ A +  T  L + R +F  LIG L+ +  K Y+D        +  +  +    NLK     L+DF I+ TLG GGFGRVELV    + +K++A+K +KK++IV T+QQ+H+ SEK+I+    S +I RLY TF D+KY+Y+L E CLGGELW ILRDR  F+D  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL YELL G+PPF   DPMK YN+ L+GI+   I    KI   AA+LI++LCR  P ERLGN KNG+++I+ HK+F+GF+WEG++  T+  P  P +  P DTSNFD F  +SD  PPD+NSGWD DF
Sbjct:   17 ELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQAQKQSASTLQG--EPRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFA----NLK-----LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF 686

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Mouse
Match: Prkg2 (protein kinase, cGMP-dependent, type II [Source:MGI Symbol;Acc:MGI:108173])

HSP 1 Score: 617.076 bits (1590), Expect = 0.000e+0
Identity = 319/649 (49.15%), Postives = 422/649 (65.02%), Query Frame = 3

Query:  606 RSKRLGISGESSNHQRFQTLNKFP----------KSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIE--VREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQ--------TKEYDDESR-AKMSLS---MHSRNSAESNNLKRE------SFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            R  + G+S E +   R   LNK P          K +  KK+I  A+  N  L +LDP Q+ +++ECMY ++  +  +VI++GE G  ++V  EG  EV++ EKL+  +     FGELA+LYNC RTASVKA+     W LDR +FQ IM +T   R ++ + FL SV+L ++L E KL KI++ +EV+ Y  G  IIR+GEE  +FFI+  G VKVTQ   G +    ++ +  GEYFGEKAL+ +  R+ANI A +     L + R+ F++ +G  + LQ        T   DDE R AK S+S   +    S E   LK +      +    + EI+ATLG GGFGRVELV   K+   ++A+K ++K++IV TKQQ+HV SEK+IL E  S +I +LY TF DNKYVY+L E CLGGELW+ILRDR  FD+  ++FC+ACV EA  YLH  GI+YRDLKPENL++   GYLKL DFGFAKKIG G +TWTFCGTPEYVAPE+ILNK HDFSVDFWS+GIL YELL G PPF   D M  YN+ LKGIE+ +     KIT +   LI+RLCR  P ERLGN KNGI +I+ H++  GF+WEG+K+ ++ SP   +++GP D S FDK+  E  +PPDE SGWDKDF
Sbjct:  119 RGAKAGVSAEPTT--RTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYVIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEEYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFDELQKYLEGYVATLNRDDEKRHAKRSMSSWKLSKALSLEMIQLKEKVARFSSTSPFQNLEIIATLGVGGFGRVELV-KVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPR--KITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSYFDKYPPEKGVPPDEMSGWDKDF 762

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Mouse
Match: Prkg1 (protein kinase, cGMP-dependent, type I [Source:MGI Symbol;Acc:MGI:108174])

HSP 1 Score: 616.69 bits (1589), Expect = 0.000e+0
Identity = 322/680 (47.35%), Postives = 441/680 (64.85%), Query Frame = 3

Query:  447 ESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRL-GISGESSNHQRF----QTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKING--DEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESD-IPPDENSGWDKDF 2462
            E  ++  ++ + EK  +I+EL+R++ K +SVL                  I  R+ R  GIS E   ++ F    Q   KF KS   K +I++AI++N  +  L+ SQ+ EI++CMY     ++  +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+VK L    LW +DR  FQTIMM+TGL +  +   FL+SV  F+ L +  L K+ +++E   Y +G+ IIRQG   D+FFII  G V VT++ +   D + +R +  G++FGEKAL  E  RTAN+ A +  T  L + R +F  LIG L+ +  K Y+D        +  +  +    NLK     L+DF I+ TLG GGFGRVELV    + +K++A+K +KK++IV T+QQ+H+ SEK+I+    S +I RLY TF D+KY+Y+L E CLGGELW ILRDR  F+D  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL YELL G+PPF   DPMK YN+ L+GI+   I    KI   AA+LI++LCR  P ERLGN KNG+++I+ HK+F+GF+WEG++  T+  P  P +  P DTSNFD F  +SD  PPD+NSGWD DF
Sbjct:   16 EERIKELEKRLSEKEEEIQELKRKLHKCQSVL------------PVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFA----NLK-----LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF 671

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Mouse
Match: Prkg2 (protein kinase, cGMP-dependent, type II [Source:MGI Symbol;Acc:MGI:108173])

HSP 1 Score: 587.415 bits (1513), Expect = 0.000e+0
Identity = 305/640 (47.66%), Postives = 405/640 (63.28%), Query Frame = 3

Query:  606 RSKRLGISGESSNHQRFQTLNKFP----------KSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIE--VREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQ--------TKEYDDESR-AKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            R  + G+S E +   R   LNK P          K +  KK+I  A+  N  L +LDP Q+ +++ECMY ++  +  +VI++GE G  ++V  EG  EV++ EKL+  +     FGELA+LYNC RTASVKA+     W LDR +FQ IM +T   R ++ + FL SV+L ++L E KL KI++ +EV+ Y  G  IIR+GEE  +FFI+  G VKVTQ   G +    ++ +  GEYFGEKAL+ +  R+ANI A +     L + R+ F++ +G  + LQ        T   DDE R AK S+S    + A    L  E   L +                  V  K+   ++A+K ++K++IV TKQQ+HV SEK+IL E  S +I +LY TF DNKYVY+L E CLGGELW+ILRDR  FD+  ++FC+ACV EA  YLH  GI+YRDLKPENL++   GYLKL DFGFAKKIG G +TWTFCGTPEYVAPE+ILNK HDFSVDFWS+GIL YELL G PPF   D M  YN+ LKGIE+ +     KIT +   LI+RLCR  P ERLGN KNGI +I+ H++  GF+WEG+K+ ++ SP   +++GP D S FDK+  E  +PPDE SGWDKDF
Sbjct:  119 RGAKAGVSAEPTT--RTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYVIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEEYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFDELQKYLEGYVATLNRDDEKRHAKRSMSSWKLSKA----LSLEMIQLKE-----------------KVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPR--KITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSYFDKYPPEKGVPPDEMSGWDKDF 733

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Mouse
Match: Prkg1 (protein kinase, cGMP-dependent, type I [Source:MGI Symbol;Acc:MGI:108174])

HSP 1 Score: 392.119 bits (1006), Expect = 1.249e-128
Identity = 200/387 (51.68%), Postives = 256/387 (66.15%), Query Frame = 3

Query: 1305 EEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESD-IPPDENSGWDKDF 2462
            EE  RTAN+ A +  T  L + R +F  LIG L+ +  K Y+D        +  +  +    NLK     L+DF I+ TLG GGFGRVELV    + +K++A+K +KK++IV T+QQ+H+ SEK+I+    S +I RLY TF D+KY+Y+L E CLGGELW ILRDR  F+D  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL YELL G+PPF   DPMK YN+ L+GI+   I    KI   AA+LI++LCR                     +F+GF+WEG++  T+  P  P +  P DTSNFD F  +SD  PPD+NSGWD DF
Sbjct:   29 EEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFA----NLK-----LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKIAKNAANLIKKLCR---------------------WFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF 382

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BLAST of cGMP-dependent protein kinase vs. UniProt/SwissProt
Match: sp|A8X6H1|EGL4_CAEBR (cGMP-dependent protein kinase egl-4 OS=Caenorhabditis briggsae OX=6238 GN=egl-4 PE=3 SV=2)

HSP 1 Score: 645.58 bits (1664), Expect = 0.000e+0
Identity = 321/698 (45.99%), Postives = 458/698 (65.62%), Query Frame = 3

Query:  444 HESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXX-------------------XXXXXXXXXXIKARSKRLGISGESSNHQ-RFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDE--IEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFH---LNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
             +S++    + I E   ++  LQRE DKL+SVL+Q     +                           +  + R+K++ +S E +N + +  TL  + K+   K++IR A+  N  L +L   Q+ E++ CMYE  A    +VI+EGE G++L+V  EGE +V ++   +GKM      GELA+LYNC RTASV+AL    LWVLDR++FQ I  + G+ER   +  FL  V++F +L+E ++ KI ++++   Y  G  I+RQGE+ D+FF+I +G VKVTQ+I G++   E+R ++ G++FGE+ALL +  RTANI A     EVL L R++F++LIGDL+ L+ K+Y D+ R   +L     +  +  +  RE F    L + + +ATLG GGFGRVELV  + D +K+YALK +KK++IV T+QQ+H+ +E+ I++E  + +I +LY TF D K+VY+L EVCLGGELW  LRDR HFDDY  RF +ACVLE L YLH + IVYRDLKPEN L+ NSGYLKL DFGFAKK+  G +TWTFCGTPEYV+PEIILNK HD + D+W++GI   EL+ G PPF A+DPMK Y + LKG++   I  N +I   A +L+++LCR  P ERLG+G  G+ +IR H++F GFDWEG+++ T+K P  PK+N P D +NFD +  ++D+PPDE SGWD+ F
Sbjct:   55 QQSIVEGHIKRISELEGEVTTLQRECDKLRSVLEQKAQSAASPGQPPSPSPRTDQLGNDLQQKAVFPADGTQQRAKKIAVSAEPTNFENKPATLQHYNKTVAAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGATLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQIINFLSKVSIFANLTEDRISKIADVMDQDYYDGGHYILRQGEKGDAFFVINSGQVKVTQQIEGEKEAREIRILNQGDFFGERALLGDEVRTANIIAQAPGVEVLTLDRESFTKLIGDLDTLR-KDYGDKERV-ATLVREPPSPVKIVDDFREEFANVTLKNVKRLATLGVGGFGRVELVCVNGDKSKTYALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANSGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEI-PNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRTKTLKPPILPKVNNPADVTNFDNYPPDNDVPPDEFSGWDEGF 749

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BLAST of cGMP-dependent protein kinase vs. UniProt/SwissProt
Match: sp|O76360|EGL4_CAEEL (cGMP-dependent protein kinase egl-4 OS=Caenorhabditis elegans OX=6239 GN=egl-4 PE=1 SV=2)

HSP 1 Score: 643.269 bits (1658), Expect = 0.000e+0
Identity = 319/698 (45.70%), Postives = 452/698 (64.76%), Query Frame = 3

Query:  441 NHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKA-------------------RSKRLGISGESSNHQ-RFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGD--EIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRE--SFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
              ++++    + I E   ++  LQRE DKL+SVL+Q     +           +                    R+K++ +S E +N + +  TL  + K+   K++IR A+  N  L +L   Q+ E++ CMYE  A    +VI+EGE G++L+V  EGE +V ++  L+GKM      GELA+LYNC RTASV+AL    LWVLDR++FQ I  + G+ER   L  FL  V++F++LSE ++ K+ ++++   Y  G  IIRQGE+ D+FF+I +G VKVTQ+I G+    E+R ++ G++FGE+ALL E  RTANI A     EVL L R++F +LIGDL  L+ K+Y D+ R    +          ++ + E     L + + +ATLG GGFGRVELV  + D  K++ALK +KK++IV T+QQ+H+ +E+ I++E  + +I +LY TF D K+VY+L EVCLGGELW  LRDR HFDDY  RF +ACVLE L YLH + IVYRDLKPEN L+ N+GYLKL DFGFAKK+  G +TWTFCGTPEYV+PEIILNK HD + D+W++GI   EL+ G PPF A+DPMK Y + LKG++   I  N +I   A +L+++LCR  P ERLG+G  G+ +IR H++F GFDWEG++S T+K P  PK++ P D +NFD +  ++D+PPDE SGWD+ F
Sbjct:   85 QQQTIVEGHIKRISELEGEVTTLQRECDKLRSVLEQKAQSAASPGGQPPSPSPRTDQLGNDLQQKAVLPADGVQRAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIEGETEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLESLK-KDYGDKERLAQVVREPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEI-PNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDEGF 780

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BLAST of cGMP-dependent protein kinase vs. UniProt/SwissProt
Match: sp|Q03042|KGP1_DROME (cGMP-dependent protein kinase, isozyme 1 OS=Drosophila melanogaster OX=7227 GN=Pkg21D PE=1 SV=2)

HSP 1 Score: 625.935 bits (1613), Expect = 0.000e+0
Identity = 319/634 (50.32%), Postives = 421/634 (66.40%), Query Frame = 3

Query:  597 IKARSKRLGISGESSNHQRFQT----LNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKAL-KTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKI---NGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRA-KMSLSMHSRNSAESNNLKRE--SFHLNDFEIVATLGFGGFGRVELV-VNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            + A  K+ G+S ES      Q+    + K+ K    K+ I+ AIM+N  L  +D SQV E+++ MY K      FVIREGE G  LYV+  GEF V +  K++ KM   K FGELA+LYNC RTAS++ L +   +WVLDR +FQ IMM TGL+R ++   FL SV L  +LSE  L KI +++E++ Y+ G  IIRQG   DSFF+I  G V+VTQK+   + +E E+R +S G+YFGE+AL+ E KRTANI A+    E L L R +F  LIGDL  L+ K+Y DESR   M  +  S        L++E     L D E+V+TLG GGFGRVELV  + +D    +ALK +KK++IV TKQ++H+ SE+ I+L  +S +ICRLY TF D KYVY+L E C+GGE+W +LRDR  F+D   +F + CVL+A  YLH+RGI+YRDLKPENL++   GY+K+ DFGFAK+IG   +TWTFCGTPEYVAPEIILNK HD +VD+W++GIL +ELLNG PPF A DPM+ YN+ LKGI+   I     I+  A  LI+RLCR +P ERLG    GI++I+ HK+F GFDW+G+ S  +  PF   I  P D   FD+F  + + PPDE SGWD DF
Sbjct:  137 MPAAIKKQGVSAESCVQSMQQSYSIPIPKYEKDFSDKQQIKDAIMDNDFLKNIDASQVRELVDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVLDKMGAGKAFGELAILYNCTRTASIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAKIADVLELEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALINEDKRTANIIALSPGVECLTLDRDSFKRLIGDLCELKEKDYGDESRKLAMKQAQESCRDEPKEQLQQEFPDLKLTDLEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDM--IAFPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTDVRYFDRFPCDLNEPPDELSGWDADF 768

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BLAST of cGMP-dependent protein kinase vs. UniProt/SwissProt
Match: sp|P00516|KGP1_BOVIN (cGMP-dependent protein kinase 1 OS=Bos taurus OX=9913 GN=PRKG1 PE=1 SV=2)

HSP 1 Score: 618.231 bits (1593), Expect = 0.000e+0
Identity = 323/680 (47.50%), Postives = 441/680 (64.85%), Query Frame = 3

Query:  447 ESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRL-GISGESSNHQRF----QTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQK--INGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESD-IPPDENSGWDKDF 2462
            E  ++  ++ + EK  +I+EL+R++ K +SVL                  I  R+ R  GIS E   ++ F    Q   KF KS   K +I++AI++N  +  L+ SQ+ EI++CMY     ++  +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+VK L    LW +DR  FQTIMM+TGL +  +   FL+SV  F+ L E  L K+ +++E   Y +G+ IIRQG   D+FFII  G V VT++   N D + +R +  G++FGEKAL  E  RTAN+ A +  T  L + R +F  LIG L+ +  K Y+D        +  +  +    NLK     L+DF I+ TLG GGFGRVELV    + +K++A+K +KK++IV T+QQ+H+ SEK+I+    S +I RLY TF D+KY+Y+L E CLGGELW ILRDR  F+D  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL YELL G+PPF   DPMK YN+ L+GI+   I    KI   AA+LI++LCR  P ERLGN KNG+++I+ HK+F+GF+WEG++  T+  P  P +  P DTSNFD F  ++D  PPD+NSGWD DF
Sbjct:   16 EERIKELEKRLSEKEEEIQELKRKLHKCQSVL------------PVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGKVNVTREDSPNEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFA----NLK-----LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 671

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BLAST of cGMP-dependent protein kinase vs. UniProt/SwissProt
Match: sp|P0C605|KGP1_MOUSE (cGMP-dependent protein kinase 1 OS=Mus musculus OX=10090 GN=Prkg1 PE=1 SV=1)

HSP 1 Score: 616.69 bits (1589), Expect = 0.000e+0
Identity = 322/680 (47.35%), Postives = 441/680 (64.85%), Query Frame = 3

Query:  447 ESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRL-GISGESSNHQRF----QTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKING--DEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESD-IPPDENSGWDKDF 2462
            E  ++  ++ + EK  +I+EL+R++ K +SVL                  I  R+ R  GIS E   ++ F    Q   KF KS   K +I++AI++N  +  L+ SQ+ EI++CMY     ++  +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+VK L    LW +DR  FQTIMM+TGL +  +   FL+SV  F+ L +  L K+ +++E   Y +G+ IIRQG   D+FFII  G V VT++ +   D + +R +  G++FGEKAL  E  RTAN+ A +  T  L + R +F  LIG L+ +  K Y+D        +  +  +    NLK     L+DF I+ TLG GGFGRVELV    + +K++A+K +KK++IV T+QQ+H+ SEK+I+    S +I RLY TF D+KY+Y+L E CLGGELW ILRDR  F+D  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL YELL G+PPF   DPMK YN+ L+GI+   I    KI   AA+LI++LCR  P ERLGN KNG+++I+ HK+F+GF+WEG++  T+  P  P +  P DTSNFD F  +SD  PPD+NSGWD DF
Sbjct:   16 EERIKELEKRLSEKEEEIQELKRKLHKCQSVL------------PVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT-CLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFA----NLK-----LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF 671

[Close]

BLAST of cGMP-dependent protein kinase vs. TrEMBL
Match: A0A1S3HLV4 (cGMP-dependent protein kinase OS=Lingula unguis OX=7574 GN=LOC106156342 PE=3 SV=1)

HSP 1 Score: 705.671 bits (1820), Expect = 0.000e+0
Identity = 347/667 (52.02%), Postives = 462/667 (69.27%), Query Frame = 3

Query:  498 IEELQREIDKLKSVLDQTXXXX------XXXXXXXXXXXIKARSKRLGISGESSNHQRFQ-TLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKING--DEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESR-AKMSLSMHSRNSAESNNLKRE--SFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            +++L+REIDKL+SVL+ T          +   + S +     R K+ G+SGES+N  R    L  F K    K++I+ AI++N  L  LD +Q+ E+I+CMYE+   +  F+I EGE G+ L+V+ EGE  V KD + +G M+  + FGELA+LYNC RTASVKAL    LWVLDR++FQ IMMKTGL+RQ +   FL SV+L + L   KL KI  ++E+  + +G+CIIR+GE  D+FFII  G V+V QK+ G  D  ++R +  G+YFGEKALL E  RTA++ A     E L + R++F++LIGDLN L+ K+Y DE+R A+ +       S     ++RE  +  L+  E++ATLG GGFGRVEL+  S D TK+YALK +KK++IV+T+QQ+H+ SEKKI++  +S++I RLY TF DNKYVY+L E CLGGELW ILRDR HFD+   RFC+ACV+EA  YLHS+GI+YRDLKPENLL+   GY+KL DFGFAK++G G +TWTFCGTPEYVAPEIILNK HD +VD+WS+GIL YELL G+PPF  +DPMK YN+ LKGI+      +  I   A +LI++LCR  P ERLG  KNGI +I+ HK+FQGFDW G+    +  P  P++ GP D SNFD +  + DIP DE SGWD DF
Sbjct:   85 VQKLEREIDKLRSVLELTVHKDGKPDILATIQEDSVMVGQATRGKKQGVSGESTNFSRSSVALKHFDKDFRSKQLIKDAILDNDFLKNLDKAQLREVIDCMYERTTQKGQFIITEGEAGQHLFVSAEGELNVLKDGRSLGTMTAGRAFGELAILYNCTRTASVKALSDARLWVLDRSVFQAIMMKTGLQRQAENIKFLRSVSLLKRLPSEKLAKIASVLEMDFFHEGECIIREGEAGDTFFIINKGEVEVQQKLKGFSDPQKIRNLKRGDYFGEKALLSEDYRTASVVAKAPGVECLTIDRESFTQLIGDLNELREKDYGDEARNAQRASESDIPASPGRQKMERELANVGLHQLEVLATLGLGGFGRVELIQLSTDRTKTYALKCLKKKHIVETRQQEHIYSEKKIMMNARSNFIARLYRTFKDNKYVYMLMEACLGGELWTILRDRGHFDEVTARFCVACVIEAFDYLHSKGIIYRDLKPENLLLDTKGYVKLVDFGFAKRVGHGSKTWTFCGTPEYVAPEIILNKGHDHAVDYWSLGILMYELLTGSPPFSTSDPMKTYNIILKGIDVVEFTQH--IRKNAQNLIKKLCRDNPAERLGYQKNGIADIKKHKWFQGFDWHGLHRQILTPPIQPRVRGPTDFSNFDNYPKDKDIPQDELSGWDNDF 749

[Close]

BLAST of cGMP-dependent protein kinase vs. TrEMBL
Match: A0A0X3NTH0 (cGMP-dependent protein kinase, isozyme 1 OS=Schistocephalus solidus OX=70667 GN=KGP1 PE=4 SV=1)

HSP 1 Score: 695.271 bits (1793), Expect = 0.000e+0
Identity = 359/711 (50.49%), Postives = 469/711 (65.96%), Query Frame = 3

Query:  489 NLKIEELQREIDKLKSVLDQTXXXXX--XXXXXXXXXXIKARSKRLGISGESSNHQRFQTLNKF-PKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKING-----DEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGP-TEVLCLYRQAFSELIGDLNVLQTKEYDD----ESRAKM-----SLSMHSRNSAES----------NNLKR-------------------------ESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            N   + LQR+  K  S  DQT           S  +  + A +KRLG+SGE +       + K+  K  + ++ IR A+ NN  L  LD  Q+ EI+ CMYE    E C++I EGE+G  LYVA EGE+EV+   K +  M    CFGELALLYNCKRTAS+KA++   LWVL+R +FQ IMMKTG+E+ ++   FL SV L ++L E KL +I +++E Q +  G+CIIRQ E+ADSFFII++G VKVT K+ G     +EIE+R M+ GEYFGEKALL EG+RTANIYA+     ++LCLYR+ F ELIG++  L  +EY D    E+R+ +     S  M + NSA +            L+R                         E+  + D E VA +G GGFGRVELV  + D +  +ALK MKK +IV+TKQQ+HV SEK+IL+   S +IC+L+ TF DNK+VY+L E C GGELW +LRDR  FDD +TRF LACV+EA  YLH   I+YRDLKPEN+L+  +GY+KLCDFGFAK++G   +TWTFCGTPEYVAPE+ILNK HD + D+WS+GILT ELL G PPF A++P+KIY   L+GIE  ++ H+  I+ KA  LI+RLCR  P ERLG G+ GI+EIR  KYFQGFDWEG+++ +  SPF+PK++GP D SNFD+F    D+PPDE SGWDKDF
Sbjct:  287 NSMTKTLQRQSSKGSSGSDQTSVVTPGLELSPSLPVMSMAAVNKRLGVSGEPTTEPTTPLVMKYYDKDAKSRQEIRNALRNNEYLKNLDAVQLQEIVSCMYEYSIKEGCYIILEGEDGNHLYVAAEGEYEVWAGGKYLYTMGPGNCFGELALLYNCKRTASIKAVRAARLWVLERNVFQHIMMKTGIEKMEERVKFLSSVPLLKNLDEAKLQRITDVLEAQFHPAGECIIRQDEQADSFFIIQSGEVKVTMKVTGADGNQNEIEIRRMTRGEYFGEKALLGEGRRTANIYAISPSGVDLLCLYRKDFLELIGNIEDLHHREYVDLEHLEARSGLQKPEDSTVMLTENSAYALKTLQQASVDQQLERRQQEELRKEKTPSSKKLYLREYQICENLRITDLERVAVIGQGGFGRVELVKPTNDSSIGFALKRMKKVHIVETKQQEHVHSEKRILMCVDSPFICKLFKTFKDNKFVYMLMEFCPGGELWTVLRDRRVFDDKLTRFSLACVIEAFDYLHHNSIIYRDLKPENMLLTVNGYIKLCDFGFAKRLGGQRKTWTFCGTPEYVAPEVILNKGHDLAADYWSLGILTCELLMGTPPFQASEPIKIYMKALRGIEAYDLAHHKNISAKAHQLIKRLCRLNPTERLGMGRLGIQEIRNQKYFQGFDWEGVRNRSSPSPFHPKVSGPLDFSNFDQFPITDDLPPDETSGWDKDF 997

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BLAST of cGMP-dependent protein kinase vs. TrEMBL
Match: A0A0X3PBC4 (cGMP-dependent protein kinase, isozyme 1 OS=Schistocephalus solidus OX=70667 GN=KGP1 PE=4 SV=1)

HSP 1 Score: 694.886 bits (1792), Expect = 0.000e+0
Identity = 359/711 (50.49%), Postives = 469/711 (65.96%), Query Frame = 3

Query:  489 NLKIEELQREIDKLKSVLDQTXXXXX--XXXXXXXXXXIKARSKRLGISGESSNHQRFQTLNKF-PKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKING-----DEIEVREMSSGEYFGEKALLEEGKRTANIYAVK-GPTEVLCLYRQAFSELIGDLNVLQTKEYDD----ESRAKM-----SLSMHSRNSAES----------NNLKR-------------------------ESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            N   + LQR+  K  S  DQT           S  +  + A +KRLG+SGE +       + K+  K  + ++ IR A+ NN  L  LD  Q+ EI+ CMYE    E C++I EGE+G  LYVA EGE+EV+   K +  M    CFGELALLYNCKRTAS+KA++   LWVL+R +FQ IMMKTG+E+ ++   FL SV L ++L E KL +I +++E Q +  G+CIIRQ E+ADSFFII++G VKVT K+ G     +EIE+R M+ GEYFGEKALL EG+RTANIYA+     ++LCLYR+ F ELIG++  L  +EY D    E+R+ +     S  M + NSA +            L+R                         E+  + D E VA +G GGFGRVELV  + D +  +ALK MKK +IV+TKQQ+HV SEK+IL+   S +IC+L+ TF DNK+VY+L E C GGELW +LRDR  FDD +TRF LACV+EA  YLH   I+YRDLKPEN+L+  +GY+KLCDFGFAK++G   +TWTFCGTPEYVAPE+ILNK HD + D+WS+GILT ELL G PPF A++P+KIY   L+GIE  ++ H+  I+ KA  LI+RLCR  P ERLG G+ GI+EIR  KYFQGFDWEG+++ +  SPF+PK++GP D SNFD+F    D+PPDE SGWDKDF
Sbjct:  175 NSMTKTLQRQSSKGSSGSDQTSVVTPGLELSPSLPVMSMAAVNKRLGVSGEPTTEPTTPLVMKYYDKDAKSRQEIRNALRNNEYLKNLDAVQLQEIVSCMYEYSIKEGCYIILEGEDGNHLYVAAEGEYEVWAGGKYLYTMGPGNCFGELALLYNCKRTASIKAVRAARLWVLERNVFQHIMMKTGIEKMEERVKFLSSVPLLKNLDEAKLQRITDVLEAQFHPAGECIIRQDEQADSFFIIQSGEVKVTMKVTGADGNQNEIEIRRMTRGEYFGEKALLGEGRRTANIYAISPSGVDLLCLYRKDFLELIGNIEDLHHREYVDLEHLEARSGLQKPEDSTVMLTENSAYALKTLQQASVDQQLERRQQEELRKEKTPSSKKLYLREYQICENLRITDLERVAVIGQGGFGRVELVKPTNDSSIGFALKRMKKVHIVETKQQEHVHSEKRILMCVDSPFICKLFKTFKDNKFVYMLMEFCPGGELWTVLRDRRVFDDKLTRFSLACVIEAFDYLHHNSIIYRDLKPENMLLTVNGYIKLCDFGFAKRLGGQRKTWTFCGTPEYVAPEVILNKGHDLAADYWSLGILTCELLMGTPPFQASEPIKIYMKALRGIEAYDLAHHKNISAKAHQLIKRLCRLNPTERLGMGRLGIQEIRNQKYFQGFDWEGVRNRSSPSPFHPKVSGPLDFSNFDQFPITDDLPPDETSGWDKDF 885

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BLAST of cGMP-dependent protein kinase vs. TrEMBL
Match: V3Z912 (cGMP-dependent protein kinase OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_127769 PE=3 SV=1)

HSP 1 Score: 689.878 bits (1779), Expect = 0.000e+0
Identity = 346/681 (50.81%), Postives = 468/681 (68.72%), Query Frame = 3

Query:  459 RAAKREIDEKNLKIEELQREIDKLKSVLD-------QTXXXXXXXXXXXXXXXIKARSKRLGISGESSNHQRFQT-LNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKING--DEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESF---HLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            R   ++I+E N +I  L+ E+ KLKSVL        +     +       +   + RSK+ G+SGESS++ +    L    K    K++I+ AI++N  L  LD +QV EI++CMY+K   E  ++I+EGE G  LYV+ +GE EV K+  ++G+M++ + FGELA+LYNC RTASVKAL    +WVLDR MFQ IMMKTG++R+ +   +L SV L   L   KL K+ +++E+  Y +G+ IIR+G   DSFFI+  G VKVTQ+I G  +  E+R++  G+YFGEK+LL E +RTAN+ A+    E L + R +F++LIGDLN L+TK+Y DE+R    LS      +   +   E F    ++D ++VATLG GGFGRVELV  S D  K+YALK +KK++IV T+QQ+H+ SEK+I+L  ++ +I RL+ TF DNKYVY++ E CLGGELW ILRDR  FDD  TRF ++CV+EA  YLH +GI+YRDLKPENLL+ N GY+KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD + D+WS+GIL +ELL G+PPF  +DPMK YN+ LKGI+   I    KI+  A +LI++LCR  P+ERLG GKNGI +I+ HK+FQGFDWEG+ + ++  P  PK+  P D SNFD +  ++DIP DE SGWD DF
Sbjct:   48 RDKTKQINENNKEITRLKEEVHKLKSVLQLKVHKDGKPDILATIQETEPPVVVQEVRSKKQGVSGESSSNSQSNVELKHHDKDFRSKQLIKDAILDNDFLKNLDSTQVREIVDCMYDKKIKEGHYIIKEGESGNHLYVSADGEVEVQKEGTILGRMASGRAFGELAILYNCTRTASVKALTEVRVWVLDRAMFQAIMMKTGIQRRDENIRYLRSVPLLRDLPADKLAKLADVLEIDFYHEGEYIIREGATGDSFFILNKGEVKVTQRIQGHNNPQEIRKLKRGDYFGEKSLLSEDRRTANVIALPPGVECLTVDRDSFNQLIGDLNELRTKDYGDEARGASRLSGELTPGSRDKDRILEEFVNIKIDDLDVVATLGMGGFGRVELVQLSNDKMKTYALKCLKKKHIVDTRQQEHIYSEKQIMLTSRTPFIARLFKTFRDNKYVYMMMEACLGGELWTILRDRGSFDDKTTRFYVSCVVEAFKYLHHKGIIYRDLKPENLLLDNKGYIKLVDFGFAKKIGAGKKTWTFCGTPEYVAPEIILNKGHDHAADYWSLGILMFELLTGSPPFSGSDPMKTYNIILKGIDV--IEFPRKISRNAHALIKKLCRDAPVERLGYGKNGITDIKKHKWFQGFDWEGLLNHSITPPIIPKVKNPTDYSNFDSYPKDNDIPADETSGWDADF 726

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BLAST of cGMP-dependent protein kinase vs. TrEMBL
Match: A0A5N4A4B0 (Uncharacterized protein OS=Photinus pyralis OX=7054 GN=PPYR_14115 PE=4 SV=1)

HSP 1 Score: 689.493 bits (1778), Expect = 0.000e+0
Identity = 347/695 (49.93%), Postives = 473/695 (68.06%), Query Frame = 3

Query:  444 HESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRL-----------GISGESSN--------HQRFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKING--DEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNI-LHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            H  LL + ++E+  K  ++ +LQRE+ KLKSVL Q     +     +SL +  A + R+           G+S ESS+        H     + K  K    K++I+ AIM+N+ L  LD  QV EI++ MY +      +VIREG+ G  LYV+ EG+FEV KD+K++G+M + K FGELA+LYNC RTAS++ +    +WVLDR +FQ IM++TGL+R +D   FL SV L  +LS   L KI +++EV+ Y  G  I+RQG   D+FFII +G VK+TQ+I+G  DE ++R ++ G+YFGE+ALL E  RTA++ A+    E L L R++F +LIGDL+V + K+Y D+ R  M  S  +   AE      +   L+D +I+ATLG GGFGRVELV  + D + ++ALK +KKQ+IV T+QQDH+ SEK I++ C+S +ICRLY TF D+KYVY+L E CLGGE+W ILRDR  FDD+ TRF  ACV+EA  YLH+RGI+YRDLKPENLL+ N GY+KL DFGF+K++G   +TWTFCGTPEYVAPE ILNK HD +VD+W++GIL YELL G+PPF A+DPMK YN+ LKGI+  +   HN  ++  A SLI++LCR LP ERLG  + GI++I+ HK+FQGFDW+G+++ ++  P    + GP DTSNFD F  + DIPPDE S WD DF
Sbjct:  263 HTKLLES-RKEVHSKESQVIKLQREVHKLKSVLQQATCFSNESDILTSLQEQHAMANRVPPAAVTFNKKQGVSAESSDIIGPAGDIH-----VQKHEKDFRSKQLIKDAIMDNNFLKHLDSLQVREIVDSMYPRQCEAGSYVIREGDAGAHLYVSAEGDFEVIKDDKVLGRMGSGKAFGELAILYNCTRTASIRVVTDSKVWVLDRKVFQQIMVRTGLQRLQDNINFLRSVPLLANLSNDVLAKIADVLEVEFYPSGAYIVRQGASGDTFFIISSGNVKITQRISGGLDEEDIRTLTRGDYFGEQALLREECRTASVIAMSPGVECLTLDRESFIQLIGDLSVFKEKDYGDDQRMLMRPSSVASVCAEKQEY--DYMRLDDLDIIATLGVGGFGRVELVQYANDQSMTFALKCLKKQHIVDTQQQDHIFSEKMIMMCCRSPFICRLYRTFRDSKYVYMLLEACLGGEVWTILRDRACFDDHTTRFITACVIEAFDYLHNRGIIYRDLKPENLLLDNDGYVKLVDFGFSKRLGYSSKTWTFCGTPEYVAPETILNKGHDRAVDYWALGILMYELLTGSPPFTASDPMKTYNLILKGIDMIDFEKHN--VSRSAQSLIKKLCRDLPSERLGYQRGGIQDIKKHKWFQGFDWDGLRARSLPVPITKLVRGPCDTSNFDCFDKDVDIPPDELSDWDIDF 947

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BLAST of cGMP-dependent protein kinase vs. Ensembl Cavefish
Match: prkg1b (protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:ZDB-GENE-080225-40])

HSP 1 Score: 613.224 bits (1580), Expect = 0.000e+0
Identity = 323/681 (47.43%), Postives = 435/681 (63.88%), Query Frame = 3

Query:  447 ESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRL-GISGESSNHQRFQ-----TLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIEV--REMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINES-DIPPDENSGWDKDF 2462
            E  +R  +  + EK  +I EL+R++ K +SVL                  +  R++R  GIS E      FQ      L K  KS+  K++I++AI++N  +  L+ SQ+ EI  C           +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+V+ L    LW +DR  FQTIMM+TGL +  +   FL+SV  F+ L+E  L K+ +++E   Y DG+ IIRQG   D+FFII  G V VT++ +  +  V  R +  G++FGEKAL  E  RTAN+ A    T  L + R +F  LIG L+ + +K Y+D           ++   E+ N    +  L DF I+ TLG GGFGRVELV    + TK++A+K +KK++IV T+QQ+H+ SEK I+ E  S +I RLY TF D+KY+Y+L E CLGGELW ILRDR  F+D  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL YELL G+PPF   DPMK YN+ L+GI+   I    KIT  AA+LI++LCR  P ERLGN KNG+++I+ HK+F+GF+WEG++  T+  P  P ++ P DTSNFD F  +S D PPD+NSGWD DF
Sbjct:   16 EERIREMELRLAEKEEEIAELKRKLHKCQSVLPSAPL-------------MGPRTRRAQGISAEPQPFTSFQQLTSEALRKHAKSDRSKELIKEAILDNDFMKNLELSQIQEIESC-----------IIKEGDVGSLVYVMEDGKVEVTKEGMKLCTMGPGKVFGELAILYNCTRTATVQTLTNVKLWAIDRQCFQTIMMRTGLIKHAEYMEFLKSVPTFQGLAEEILSKLADVLEETHYDDGEYIIRQGARGDTFFIISKGKVNVTREDSPSDTPVYLRALGKGDWFGEKALQGEDIRTANVIAADAVT-CLVIDRDSFKHLIGGLDDVSSKGYEDAG---------AKAKYEAENAFFSNLKLADFNIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKHIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPDVSSPTDTSNFDSFPEDSEDPPPDDNSGWDTDF 660

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BLAST of cGMP-dependent protein kinase vs. Ensembl Cavefish
Match: ENSAMXT00000002114.2 (cGMP-dependent protein kinase 2-like [Source:NCBI gene;Acc:103041230])

HSP 1 Score: 606.29 bits (1562), Expect = 0.000e+0
Identity = 333/723 (46.06%), Postives = 457/723 (63.21%), Query Frame = 3

Query:  432 EAENHESLLRAAKREIDEKNLKIEELQ----------------REIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRLGISGE-SSNH----QRFQTLN----KFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKING--DEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQT--KEY------DDESRAKMSLSMHSRNSAESNNLKRESFH-----------LNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            E    E  L+  +RE++ K L+I++LQ                R   +L SV++Q  +             +KA+    G+S E +S H     R Q ++    +  K + +KK+I +AIMNN  L KL+P    E+++CMYEK    N  VI+EGE G  LYV  EG  EV ++ KL+G+M     FGELA+LYNCKRTA+VKA+    +W LDR  FQ+IMM++   R ++  +FL SV+L + L E KL KIV+ +E+  +  G+ IIR+GEE ++FFII  G V VTQ   G  + +E++ +  G+YFGEKAL+ E  R+ANI A +  T+ L + R  F++++G    LQ   +EY      +DE R   + S     S ++  L+  S H           L   +I+ATLG GGFGRVELV   K+   ++ALK +KK++IV T+QQ+H+ SEK IL +   ++I RL+ TF D KYVY+L EVCLGGELW++LRD   F++   RFC+ CVLEA  YLH  GIVYRDLKPENLL+   GY+K+ DFGFAK+IG+G +TWTFCGTPEYVAPE+I+NK HDF  D WS+GIL +ELL G+PPF  +DP+KIY M L GIE+ +I    +I+ +   LI+RLC+  P ERLGN KNGI +I+ HK+FQGF+WEG++   + SP   ++NGP D S+FD F  E + PPDE SGWDKDF
Sbjct:   57 ELRAQELQLQTLQRELEAKVLQIDKLQDAIGYNNLGRSPPAPARPSHRLLSVINQGSTRFHRVAVEVHRR-LKAKE---GVSAEPTSGHFCKEHRTQHVSIERTRIRKDSGIKKLINEAIMNNDFLKKLEPQHTREMVDCMYEKVYTANQLVIQEGEPGNYLYVLAEGLLEVIQNGKLLGQMRPGTAFGELAILYNCKRTATVKAVTQSHIWALDRQTFQSIMMRSTQARHEEYFSFLRSVSLLKDLPEEKLAKIVDCLEIDYFDKGEYIIREGEEGNTFFIIAKGEVSVTQSTEGYSEPLEIKILGVGDYFGEKALISEDVRSANIIAKENDTQCLVVDRDNFNQMVGTYEELQAYLREYVEQLSINDERRIAATQSPLYERSPQAAELR--SLHEKAARLSSCSFLQQLQIIATLGMGGFGRVELV-KLKNEDTAFALKCIKKKHIVDTRQQEHIYSEKNILQQTNCNFIVRLFRTFRDEKYVYMLLEVCLGGELWSVLRDMSFFEEATARFCIGCVLEAFDYLHGMGIVYRDLKPENLLLDAEGYVKMTDFGFAKRIGLGKKTWTFCGTPEYVAPEVIMNKGHDFGADCWSLGILIFELLIGSPPFSGSDPIKIYTMVLHGIEKVDIPK--RISKRPEDLIRRLCKLNPAERLGNKKNGIIDIKKHKWFQGFNWEGLRRRKLASPLRRELNGPLDHSHFDMFPPELEEPPDELSGWDKDF 770

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BLAST of cGMP-dependent protein kinase vs. Ensembl Cavefish
Match: prkg2 (protein kinase cGMP-dependent 2 [Source:NCBI gene;Acc:103030142])

HSP 1 Score: 569.311 bits (1466), Expect = 0.000e+0
Identity = 294/647 (45.44%), Postives = 414/647 (63.99%), Query Frame = 3

Query:  600 KARSKRLGISGE-SSNHQRFQTLNKFP-------KSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIE--VREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVL--------QTKEYDDESR-AKMSLSMHSRNSAESNN---LKRESF----HLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            K +  + G+S E SS      ++ KF        K   VKK++  A+  N  L +L+  Q+ +++ECMYE+   +  FVI++GE G  L+V  +G  +VY++ KL+  ++    FGELA+LYNC RTASVKA      WVLDR +F  IM  T   R +  ++FL SV+L   L E KL KIV+ +EV+ Y  G  +IR+GEE ++F+II  G VKVTQ     E    +  +  G+YFGEKAL+ +  R+ANI A +   E L + R+ F++ +G  + L        +T   DD+ R AK S S    +S  S +   L+ ++F      ++ EI+ATLG GGFGRVELV   K+   ++ALK +KK++IV  +Q++H+ SE++IL E  S +I ++Y TF D+KYVY+L E CLGGE+W++LRDR  F++   +FC+ CV EA  YLH++ I+YRDLKPENL++ + GY+KL DFGFAKK+  G +TWTFCGTPEYVAPEIILNK H  SVDFW++GIL +ELL G+PPF  +D M  Y   LKG+E+ +     KI+ +   LI++LC+  P ERLGN KNGI +I+ H++F GF W G+K+ T+ SP   ++ GP D S FD +  E +IPPDE SGWD DF
Sbjct:  124 KRKGAKAGVSAEPSSRTYDSSSMPKFYFESARVWKEPSVKKLLTDALNKNRYLRRLEGQQIKDMVECMYERTYQQGEFVIKQGEPGNHLFVLADGNIDVYQNNKLLTSIAVWTTFGELAILYNCTRTASVKAASGVRTWVLDREVFHNIMRMTAEARHEQHRSFLRSVSLLASLPEDKLTKIVDCLEVEYYDKGDYVIREGEEGNTFYIIARGKVKVTQSTKDHEEPQVINTLQKGDYFGEKALISDDVRSANIIADEDGVECLVIDRETFTQTVGTFDELKKYLQGYVETLARDDKKRNAKRSGSNTPPSSPLSLDRIQLREKNFTSTLSFSNLEIIATLGIGGFGRVELV-KVKNENVTFALKCIKKRHIVDNRQEEHIHSERRILSETNSPFIVKMYRTFKDSKYVYMLLEACLGGEIWSMLRDRGSFEENTAKFCVGCVTEAFEYLHNKAIIYRDLKPENLMLDSDGYVKLVDFGFAKKMKCGQKTWTFCGTPEYVAPEIILNKGHGLSVDFWALGILIFELLTGSPPFTGSDQMMTYTFILKGMEKMDFPK--KISKRPGDLIRKLCKQNPSERLGNMKNGIMDIKKHRWFTGFSWSGLKARTLNSPLKREVKGPTDHSYFDNYPPEDEIPPDEISGWDMDF 767

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BLAST of cGMP-dependent protein kinase vs. Ensembl Cavefish
Match: prkg1a (protein kinase cGMP-dependent 1a [Source:ZFIN;Acc:ZDB-GENE-040426-1308])

HSP 1 Score: 555.829 bits (1431), Expect = 0.000e+0
Identity = 306/685 (44.67%), Postives = 425/685 (62.04%), Query Frame = 3

Query:  432 EAENHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRLGISGESSNHQ----RFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQK--INGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDD-ESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINES-DIPPDENSGWDKDF 2462
            E    ++L+   + E+D+K+  I++LQ E+DK +SV+      +    +       + R+KR  IS E +          TL   PKS + K +I++AI++N  +  L+ SQ+ EI++CMY     ++  +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+VK L    LW +DR  FQTIMM+TGL +  +   FL+SV  F  L E  L K+ +++E   Y DG  IIRQG   D+FFII  G V VT++   + + + +R +  G++FGEKAL        N   +   T + C    ++  LIG L  + +K  +D E++AK           E+ N    + HL+DF I+ TLG GGFGRVELV    D  K++A+K +KK++IV T+QQ+H+ SEK I+ E  S +I     TF D+KY+Y+L E CL      I   R  FDD  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + G     DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL YELL G+PPF   DPMK YN+ L+GI+   I    KIT  AA+LI++LCR  P ERLGN KNG+++I+ HK+F+GF+WEG++  T+  P +P +    DTSNFD F  ++ D PPD+NSGWD DF
Sbjct:   17 ELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQVQKHSELQE----QQRTKRQAISAEPTAFDIQELSHVTLPFNPKSAQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYSKDSCIIKEGDVGSLVYVMEDGKVEVTKEGLKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHAEYMEFLKSVPTFHGLPEEILSKLGDVLEETHYEDGDYIIRQGARGDTFFIISKGKVTVTREDAASQETVYLRSLGKGDWFGEKALQGNQISCLNTDLITLSTFINCW---SYKHLIGGLEDVSSKGSEDAEAKAKY----------EAENAFFFNLHLSDFNIIDTLGVGGFGRVELVQLKSDEYKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIT--VQTFKDSKYLYMLHEACLEESCGPIPETRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRG-----DFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKITKNAANLIKKLCRDTPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPSSP-VTSATDTSNFDSFPEDNEDPPPDDNSGWDGDF 674

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BLAST of cGMP-dependent protein kinase vs. Ensembl Cavefish
Match: prkg2 (protein kinase cGMP-dependent 2 [Source:NCBI gene;Acc:103030142])

HSP 1 Score: 532.332 bits (1370), Expect = 5.434e-178
Identity = 283/647 (43.74%), Postives = 397/647 (61.36%), Query Frame = 3

Query:  600 KARSKRLGISGE-SSNHQRFQTLNKFP-------KSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIE--VREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVL--------QTKEYDDESR-AKMSLSMHSRNSAESNN---LKRESF----HLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            K +  + G+S E SS      ++ KF        K   VKK++  A+  N  L +L+  Q+ +++ECMYE+   +  FVI++GE G  L+V  +G  +VY++ KL+  ++    FGELA+LYNC RTASVKA      WVLDR +F  IM  T   R +  ++FL SV+L   L E KL KIV+ +EV                          VKVTQ     E    +  +  G+YFGEKAL+ +  R+ANI A +   E L + R+ F++ +G  + L        +T   DD+ R AK S S    +S  S +   L+ ++F      ++ EI+ATLG GGFGRVELV   K+   ++ALK +KK++IV  +Q++H+ SE++IL E  S +I ++Y TF D+KYVY+L E CLGGE+W++LRDR  F++   +FC+ CV EA  YLH++ I+YRDLKPENL++ + GY+KL DFGFAKK+  G +TWTFCGTPEYVAPEIILNK H  SVDFW++GIL +ELL G+PPF  +D M  Y   LKG+E+ +     KI+ +   LI++LC+  P ERLGN KNGI +I+ H++F GF W G+K+ T+ SP   ++ GP D S FD +  E +IPPDE SGWD DF
Sbjct:  124 KRKGAKAGVSAEPSSRTYDSSSMPKFYFESARVWKEPSVKKLLTDALNKNRYLRRLEGQQIKDMVECMYERTYQQGEFVIKQGEPGNHLFVLADGNIDVYQNNKLLTSIAVWTTFGELAILYNCTRTASVKAASGVRTWVLDREVFHNIMRMTAEARHEQHRSFLRSVSLLASLPEDKLTKIVDCLEV--------------------------VKVTQSTKDHEEPQVINTLQKGDYFGEKALISDDVRSANIIADEDGVECLVIDRETFTQTVGTFDELKKYLQGYVETLARDDKKRNAKRSGSNTPPSSPLSLDRIQLREKNFTSTLSFSNLEIIATLGIGGFGRVELV-KVKNENVTFALKCIKKRHIVDNRQEEHIHSERRILSETNSPFIVKMYRTFKDSKYVYMLLEACLGGEIWSMLRDRGSFEENTAKFCVGCVTEAFEYLHNKAIIYRDLKPENLMLDSDGYVKLVDFGFAKKMKCGQKTWTFCGTPEYVAPEIILNKGHGLSVDFWALGILIFELLTGSPPFTGSDQMMTYTFILKGMEKMDFPK--KISKRPGDLIRKLCKQNPSERLGNMKNGIMDIKKHRWFTGFSWSGLKARTLNSPLKREVKGPTDHSYFDNYPPEDEIPPDEISGWDMDF 741

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BLAST of cGMP-dependent protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002200.1 (pep scaffold:Pmarinus_7.0:GL479132:31244:36905:-1 gene:ENSPMAG00000001993.1 transcript:ENSPMAT00000002200.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 384.8 bits (987), Expect = 3.700e-127
Identity = 171/312 (54.81%), Postives = 230/312 (73.72%), Query Frame = 3

Query: 1527 EIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            +++ATLG GGFGRV+LV   KD   ++ALK +KK+++V+++QQ+HV SEK+IL EC   +I R Y TF D K+V+LL E CLGGELW++LRD   F +   RFC+ACV+EAL+YLH+RGI+YRDLKPENLL+   GY+K+ DFGFAKK+  G + WTFCGTPEYV PE+I+N+ HD   D W++G+L YELL G PPF   DPMK YN  L G+E+ +  +  ++  +A  +I+RLCR  P ERLGN K+G+ ++R HK+FQGFDWE ++S  + SP   +++GP D  NFD F  + D+PPDE SGWD DF
Sbjct:   35 DVIATLGVGGFGRVQLV-KLKDSDVTFALKCLKKKFVVESRQQEHVYSEKRILQECSCPFIVRFYRTFRDQKFVFLLMEACLGGELWSVLRDSGGFQEVSARFCVACVVEALAYLHARGILYRDLKPENLLLDARGYIKMADFGFAKKLACGRKAWTFCGTPEYVCPEMIVNRGHDRGADCWALGVLVYELLAGVPPFSGTDPMKTYNAILWGMERVHFPN--EVGKRAEDIIRRLCRQNPSERLGNQKHGVGDVRKHKWFQGFDWESLRSNQLASPLKREVSGPTDFKNFDWFPEDLDVPPDETSGWDHDF 343

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BLAST of cGMP-dependent protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002201.1 (pep scaffold:Pmarinus_7.0:GL479132:31244:36797:-1 gene:ENSPMAG00000001993.1 transcript:ENSPMAT00000002201.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 323.553 bits (828), Expect = 1.224e-104
Identity = 154/310 (49.68%), Postives = 207/310 (66.77%), Query Frame = 3

Query: 1533 VATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            +ATLG GGFGRV+LV   KD   ++ALK +KK+++V+++QQ+HV SEK+IL EC   +I R                   GG           F +   RFC+ACV+EAL+YLH+RGI+YRDLKPENLL+   GY+K+ DFGFAKK+  G + WTFCGTPEYV PE+I+N+ HD   D W++G+L YELL G PPF   DPMK YN  L G+E+ +  +  ++  +A  +I+RLCR  P ERLGN K+G+ ++R HK+FQGFDWE ++S  + SP   +++GP D  NFD F  + D+PPDE SGWD DF
Sbjct:    1 IATLGVGGFGRVQLV-KLKDSDVTFALKCLKKKFVVESRQQEHVYSEKRILQECSCPFIVR-------------------GG-----------FQEVSARFCVACVVEALAYLHARGILYRDLKPENLLLDARGYIKMADFGFAKKLACGRKAWTFCGTPEYVCPEMIVNRGHDRGADCWALGVLVYELLAGVPPFSGTDPMKTYNAILWGMERVHFPN--EVGKRAEDIIRRLCRQNPSERLGNQKHGVGDVRKHKWFQGFDWESLRSNQLASPLKREVSGPTDFKNFDWFPEDLDVPPDETSGWDHDF 277

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BLAST of cGMP-dependent protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001814.1 (pep scaffold:Pmarinus_7.0:GL481074:830:17391:1 gene:ENSPMAG00000001637.1 transcript:ENSPMAT00000001814.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 229.18 bits (583), Expect = 7.096e-69
Identity = 113/270 (41.85%), Postives = 171/270 (63.33%), Query Frame = 3

Query: 1608 ALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINE 2417
            +LK  K+  +V+ KQ +H ++EK+IL      ++ RL  +F DN  +Y++ E   GGE+++ LR    F +  +RF  A ++ A  YLHS  ++YRDLKPENLL+   GY+++ DFGFAK+  + GRTWT CGTPEY+APEIIL+K ++ +VD+W++G+L YE+  G PPF A+ P++IY   + G  +     +F   +K   L++ L +    +R GN KNG+ +I+ HK+F   DW  +    V++PF PK  GP D SNFD +  E
Sbjct:    8 SLKATKRTKVVKLKQVEHTLNEKRILQAISFPFLVRLEYSFKDNSNLYMVLEYVPGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLK--DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFSTTDWIAIYQRKVEAPFIPKCKGPGDASNFDDYEEE 271

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BLAST of cGMP-dependent protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006766.1 (pep scaffold:Pmarinus_7.0:GL478342:9725:27922:-1 gene:ENSPMAG00000006086.1 transcript:ENSPMAT00000006766.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 196.438 bits (498), Expect = 2.414e-55
Identity = 115/333 (34.53%), Postives = 183/333 (54.95%), Query Frame = 3

Query: 1410 LQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLE-CKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKK-IGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFD 2402
            LQ     ++++  M       N   S NL+ +    +DF+ +  LG G FG+V L+   K     YA+K MKK  I+Q K++ H+M+E+ +L++  +  ++  L+ +F     +Y + +   GGEL+  L+ +  F +   +F  A +  A+ YLHS  IVYRDLKPEN+L+   G++ L DFG  K+ I     T TFCGTPEY+APE++    +D +VD+W +G + YE+L G PPF + +  ++Y   L    Q         T  A S+++ L    P +RLG   + I EI+ H +F   +W  + +  + SP+NP ++GP D  NFD
Sbjct:   57 LQLDNPRNQTQGPMENDADHINLGPSANLQAKP---SDFDFLTVLGKGSFGKV-LLAKHKSDGIFYAVKVMKKSIILQKKEEKHIMAERNVLVKNVRHPFLVGLHYSFQSADKLYFVMDYVNGGELFFHLQRQGSFPESRAQFYAAEIGSAIGYLHSLNIVYRDLKPENILLDYQGHIVLTDFGLCKEGIDPHSTTCTFCGTPEYLAPEVLKKHPYDRTVDWWCLGCVLYEMLYGLPPFYSKNLKQMYESILHQPLQLRPC----TTNAAISVLEGLLHKDPHQRLG-ATSDILEIKNHVFFSTINWNDLDAKRIPSPYNPGVSGPCDLHNFD 380

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BLAST of cGMP-dependent protein kinase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008480.1 (pep scaffold:Pmarinus_7.0:GL482122:191709:206473:1 gene:ENSPMAG00000007654.1 transcript:ENSPMAT00000008480.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 186.037 bits (471), Expect = 3.508e-51
Identity = 107/313 (34.19%), Postives = 175/313 (55.91%), Query Frame = 3

Query: 1515 LNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAIL-RDRIHFDDYITRFCLACVLEALSYLHS-RGIVYRDLKPENLLVGNSGYLKLCDFGFAKK-IGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDI---PPD 2435
            +N+F+ +  LG G FG+V ++V  K   + YA+K +KK+ IV   +  H ++E ++L   K  ++  L  +F  +  +  + E   GGEL+  L R+R+  +D  TRF  A ++ AL YLH+ + +VYRDLK ENL++   G++K+ DFG  K+ I  G    TFCGTPEY+APE++ +  +  +VD+W +G++ YE++ G  PF   D  K++ + L      +I     ++  A +L+  L +  P +RLG G +  +EI  H +F G  W+ +    +  PF P++    DT  FD+      I   PPD
Sbjct:  147 MNNFDYLKLLGKGTFGKV-ILVREKATGQYYAMKILKKEVIVAKDEVAHTLTENRVLQTTKHPFLTLLKYSFQTHDRLCFVMEYVNGGELFFHLSRERVFSEDR-TRFYGAEIVSALDYLHTEKNVVYRDLKLENLMLDKDGHIKIADFGLCKEGITDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL----MEDIRFPRTLSNDARALLSGLLKKDPKQRLGGGVDDAKEIMRHSFFAGIIWQDVYDRKMTPPFKPQVASETDTRYFDEEFTAQTITITPPD 453

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BLAST of cGMP-dependent protein kinase vs. Ensembl Yeast
Match: TPK2 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000006124])

HSP 1 Score: 235.343 bits (599), Expect = 3.833e-70
Identity = 116/304 (38.16%), Postives = 189/304 (62.17%), Query Frame = 3

Query: 1509 FHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKI-NGPKDTSNFDKFINE 2417
            + L+DF+I+ TLG G FGRV LV +  +  + YA+K +KKQ +V+ KQ +H   E+++L   +  ++ R++ TF D + ++++ +   GGEL+++LR    F + + +F  A V+ AL YLH+  I+YRDLKPEN+L+  +G++K+ DFGFAK++     TWT CGTP+Y+APE+I  K ++ SVD+WS+G+L YE+L G  PF    PMK Y   L+G     +++          L+ +L       R+GN ++G  +I+ H +F    WE + +  +++P+ P I +G  DTS FD++  E
Sbjct:   65 YTLHDFQIMRTLGTGSFGRVHLVRSVHN-GRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQT--VTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQG----KVVYPPYFHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWFSEVVWERLLAKDIETPYEPPITSGIGDTSLFDQYPEE 361

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Yeast
Match: TPK1 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication [Source:SGD;Acc:S000003700])

HSP 1 Score: 231.876 bits (590), Expect = 9.534e-69
Identity = 119/304 (39.14%), Postives = 185/304 (60.86%), Query Frame = 3

Query: 1509 FHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKI-NGPKDTSNFDKFINE 2417
            + L DF+I+ TLG G FGRV L+  S+   + YA+K +KK+ +V+ KQ +H   E+ +L      +I R++ TF D + ++++ +   GGEL+++LR    F + + +F  A V  AL YLHS+ I+YRDLKPEN+L+  +G++K+ DFGFAK   +   T+T CGTP+Y+APE++  K ++ S+D+WS GIL YE+L G  PF  ++ MK Y   L    +     N  +      L+ RL      +RLGN +NG E+++ H +F+   WE + S  +++P+ P I  G  DTS FDK+  E
Sbjct:   82 YSLQDFQILRTLGTGSFGRVHLI-RSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKY--VPDVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDV----KDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDKYPEE 378

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649])

HSP 1 Score: 230.72 bits (587), Expect = 2.323e-68
Identity = 120/305 (39.34%), Postives = 189/305 (61.97%), Query Frame = 3

Query: 1509 FHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKG-IEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKI-NGPKDTSNFDKFINE 2417
            + L+DF+I+ TLG G FGRV L+ ++ +  + YALK +KK  IV+ KQ +H   E+++L      +I R++ TF D++ V+++ +   GGEL+++LR    F + + +F  A V  AL YLHS+ I+YRDLKPEN+L+  +G++K+ DFGFAK   +   T+T CGTP+Y+APE++  K ++ SVD+WS G+L YE+L G  PF  ++ MK Y   L   ++     H       A  L+++L      ERLGN +NG E+++ H +F    WE + +  +++P+ P I  G  DTS FD++  E
Sbjct:   83 YSLSDFQILRTLGTGSFGRVHLIRSNHN-GRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKY--VPDVTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNAELKFPPFFHP-----DAQDLLKKLITRDLSERLGNLQNGSEDVKNHPWFNEVIWEKLLARYIETPYEPPIQQGQGDTSQFDRYPEE 379

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Yeast
Match: YPK1 (S/T protein kinase; phosphorylates, downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p by phosphorylation in response to compromised sphingolipid synthesis; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; human homolog SGK1 can complement a null mutant; human homolog SGK2 can complement a ypk1 ypk2 double mutant [Source:SGD;Acc:S000001609])

HSP 1 Score: 197.978 bits (502), Expect = 5.087e-54
Identity = 118/334 (35.33%), Postives = 178/334 (53.29%), Query Frame = 3

Query: 1431 DESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAK-KIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFD-KFINESDI 2426
            D    K+++S+  + S      + +   ++DF+++  +G G FG+V + V  KD  K YALK ++K YIV   +  H ++E+ +L      +I  L  +F   + +Y +     GGEL+  L+    FD    RF  A +L AL  LH   +VYRDLKPEN+L+   G++ LCDFG  K  +    +T TFCGTPEY+APE++L   +  +VD+W++G+L YE+L G PP+   D  K+Y    K I Q  ++        A  L+  L    P  RL  G NG +EIR H +F    W+ +       P+ P ++   DTSNFD +F  E  I
Sbjct:  322 DNGLGKINISIDYKPS------RNKPLSIDDFDLLKVIGKGSFGKV-MQVRKKDTQKVYALKAIRKSYIVSKSEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYFVLAFINGGELFYHLQKEGRFDLSRARFYTAELLCALDNLHKLDVVYRDLKPENILLDYQGHIALCDFGLCKLNMKDDDKTDTFCGTPEYLAPELLLGLGYTKAVDWWTLGVLLYEMLTGLPPYYDEDVPKMY----KKILQEPLVFPDGFDRDAKDLLIGLLSRDPTRRL--GYNGADEIRNHPFFSQLSWKRLLMKGYIPPYKPAVSNSMDTSNFDEEFTREKPI 642

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Yeast
Match: YPK2 (Protein kinase similar to S/T protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); human homolog SGK2 can complement a ypk1 ypk2 double mutant [Source:SGD;Acc:S000004710])

HSP 1 Score: 194.126 bits (492), Expect = 9.056e-53
Identity = 113/312 (36.22%), Postives = 171/312 (54.81%), Query Frame = 3

Query: 1497 KRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAK-KIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDK-FINESDI 2426
            K +   ++DF+++  +G G FG+V + V  KD  K YALK ++K YIV   +  H ++E+ +L      +I  L  +F   + +YL+     GGEL+  L+    F    +RF +A +L AL  LH   ++YRDLKPEN+L+   G++ LCDFG  K  +    +T TFCGTPEY+APEI+L + +  +VD+W++GIL YE++ G PP+   +   +Y    K I Q  +L        A  L+  L    P  RL  G NG +EIR H +F+   W+ +       P+ P +    DT+NFD+ F  E  I
Sbjct:  335 KNKPLSIDDFDLLKVIGKGSFGKV-MQVRKKDTQKIYALKALRKAYIVSKCEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAELLCALDSLHKLDVIYRDLKPENILLDYQGHIALCDFGLCKLNMKDNDKTDTFCGTPEYLAPEILLGQGYTKTVDWWTLGILLYEMMTGLPPYYDENVPVMY----KKILQQPLLFPDGFDPAAKDLLIGLLSRDPSRRL--GVNGTDEIRNHPFFKDISWKKLLLKGYIPPYKPIVKSEIDTANFDQEFTKEKPI 639

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Nematostella
Match: EDO38407 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCZ7])

HSP 1 Score: 649.047 bits (1673), Expect = 0.000e+0
Identity = 338/673 (50.22%), Postives = 450/673 (66.86%), Query Frame = 3

Query:  462 AAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRLGISGESSNHQRF----QTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKIN--GDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            A ++E+  K+  I  L+ E+DK +SVL    S              +AR++R GIS E  + ++     + L + PK++  K++I++AI++N  L  L+ SQV E++ECM E+    + ++I+E E G  LYV +EG+ +V K+  ++G M   K FGELA+LYNC RTASV+A  +  LW +DR  FQTIMMKTGL R  +   FL SVNL + L+E  LLKI +++E   Y +G+ IIRQG   D+FFII++G V +TQ+ N   D + VR +S G YFGEKAL  E  RTAN  A KG    L L R+AF + IG+L+ +Q  +YDD  R    +   + +   +   +  +  L D  +V TLG GGFGRVELV  + D  +++ALK +KK +IV+T+QQDH+MSEKKI++E  S +I RL+ TF D KY+Y+L EVCLGGELW ILRDR  FDD  TRF + CV+EA  YLHS+GIVYRDLKPENLL+   GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL YELL G+PPF   DPMK YN+ LKGI+  +     KIT  A +LI++LCR  P+ERLG  K G+++I  HK+F GF+W+G++S  + SP  PKI  P D SNFD +  + DIPPD+ +GWDKDF
Sbjct:    2 ALEQELRRKDELIRRLESELDKYRSVLQPPASAGPGGRS-------RARNQRQGISAEPQSAKQVADSSKPLQRHPKNSRSKELIKEAILDNDFLKNLEASQVREVVECMCERMFKRDEYIIKEKEPGSHLYVLEEGKCQVTKEGTVLGHMGPGKAFGELAILYNCTRTASVRAQTSGKLWAIDRQTFQTIMMKTGLMRTAEHMEFLRSVNLLKDLAESYLLKIADVIEETFYEEGEYIIRQGARGDTFFIIKSGNVDITQRTNVHSDPVHVRNLSKGAYFGEKALKGEDLRTANCIAGKGGVTCLVLDREAFVQFIGNLDDIQRDQYDDSQRG---VDPQTASHLRAQQDEFANVRLEDLTVVKTLGIGGFGRVELVQVAGD-KRTFALKTLKKHHIVETRQQDHIMSEKKIMMESNSPFIVRLHKTFKDKKYLYMLLEVCLGGELWTILRDRGSFDDSTTRFYVGCVIEAFQYLHSKGIVYRDLKPENLLLDGHGYCKLVDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDLSADYWSLGILMYELLTGSPPFSGTDPMKTYNIILKGIDMIDFPR--KITRNAHALIKKLCRDNPVERLGYQKGGLKDIMKHKWFDGFNWDGLRSRKLNSPIAPKIKSPVDASNFDDYPADDDIPPDDMTGWDKDF 661

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Nematostella
Match: EDO38399 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCY8])

HSP 1 Score: 590.882 bits (1522), Expect = 0.000e+0
Identity = 304/648 (46.91%), Postives = 414/648 (63.89%), Query Frame = 3

Query:  606 RSKRLGISGESSNHQRFQT-----LNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGD--EIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESR-AKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYF------------------QGFDWEGMKSMTVK-SPFN--PKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            + KR  +SGESS   + ++     L +FPK    K++I+ AI  N  L  L+ +QV EI++CMY      N  +I+EG+ G  LY   +G  +V ++ K++G+M     FGELA+LYNC+RTA+V A++   LW +DR +FQ IMM+TG+ RQ +   FL+SV L + L   +L K+ +++EV  Y  G  IIR+ E  D+F+II  G  +VTQ+I G     E+R++  G+YFGEKALL E +RTAN+ A +   E L + R  F  +IG+++ L+ K+Y DE R AK +L +       S         L D E+VATLG GGFGRVELV        +YALK +KK++I+ T+QQ+HV SEK+IL+E  S +IC++Y TF D KYVY+L E CLGGELW ILRDR  F+D   RFC+ACV+E   YLHS+GIVYRDLKPENLL+   GY+KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL +ELL G+PPF ++DPMK YN+ L+G++        +I     +LI+RLC+  P+ERLG  K+G+ +I+ HKY                   Q   W    +++ K SP     ++    D SNFD +  + DIPPDE SGWD++F
Sbjct:   19 KEKRQAVSGESSTKAQEESRTGKELERFPKDFRSKQLIKDAIFENDFLKNLEAAQVREIVDCMYSNTFQRNDVIIQEGDAGNALYAIADGRLQVTRENKVLGEMVAGMVFGELAILYNCRRTATVTAMEPTKLWKIDRRVFQIIMMRTGMIRQAEHMAFLKSVPLLKELPNAELSKLADVLEVDFYHAGDYIIRENERGDTFYIITKGSARVTQRIEGQTGPKEIRKLQKGDYFGEKALLSEDRRTANVIAEENGVECLVVDRTVFMTVIGNMDELREKDYGDEKRGAKRTLDVPEEERKVSKEFA--DLTLEDLEVVATLGTGGFGRVELV--------TYALKCLKKKHILDTRQQEHVYSEKRILMETNSPFICKIYRTFKDRKYVYMLLEACLGGELWTILRDRGTFEDATARFCIACVVEGFEYLHSKGIVYRDLKPENLLLDAKGYVKLVDFGFAKKIGSGRKTWTFCGTPEYVAPEIILNKGHDLSSDYWSLGILIFELLTGSPPFSSSDPMKTYNIILRGLDMVEFPK--RIGRNPQNLIKRLCKDNPVERLGYQKDGLSDIKKHKYVVPWFPLAGTHRRDPRTSNQTRFWLMTTTLSFKTSPIYLLIRVESSTDYSNFDVYSKDMDIPPDEMSGWDENF 654

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Nematostella
Match: EDO35228 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM62])

HSP 1 Score: 251.136 bits (640), Expect = 2.493e-76
Identity = 136/322 (42.24%), Postives = 192/322 (59.63%), Query Frame = 3

Query: 1476 SAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKG-IEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINES--DIPP 2432
            +A S   K +   L DFE+  TLG G FGRV L+   +   + YALK M    +++ KQ +HV +EK IL+  +  +I  L  T HD  ++Y+L E   GGEL+  LR    F++    F  + ++ A+ YLH   IVYRDLKPEN+L+   G++KL DFGFAK+  +  +TWT CGTPEY+APEII +K H+ +VD+W++GIL YE+L G PPF  ++P  IY   L G +E    + N      A  LI++L  +    RLG+ KNG E+++ HK+F+  DW  +    +K P NPKI+ P DT NFD +  E     PP
Sbjct:    2 AAVSTRKKDKRTTLQDFELSKTLGTGTFGRV-LLARDRRGGEFYALKIMNISEVIRLKQVEHVQNEKNILMSIEHPFIVNLLWTQHDQTFLYMLLEYACGGELFTYLRTAGRFNNGTGLFFGSEIVSAMDYLHGHSIVYRDLKPENILLDRDGHVKLTDFGFAKE--VHDKTWTLCGTPEYLAPEIIQSKGHNKAVDWWALGILIYEMLVGYPPFFDDNPFGIYEKILSGKVEWPKHMDN----TSAKDLIKKLLVHDRTRRLGSMKNGSEDVKNHKWFKVIDWNLVLQRKLKPPINPKISHPGDTRNFDDYPEEDWRGAPP 316

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Nematostella
Match: EDO37800 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEW2])

HSP 1 Score: 201.06 bits (510), Expect = 5.468e-57
Identity = 113/352 (32.10%), Postives = 190/352 (53.98%), Query Frame = 3

Query: 1428 DDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLE-CKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKK-IGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILH-----NFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            +DE        +   +  ESNN K +    +DF  +  +G G FG+V L  N ++  K YA+K + K  I +  +  H+M+E+ +L++     ++  L+ +F     +Y + +   GGEL+  L+   +F +   RF  A +  A+ YLH   I+YRDLKPEN+L+ + G++ L DFG  K+ I   G T TFCGTPEY+APE++  + +D SVD+W +G + YE++ G PPF + D  ++Y+         NILH        I+  A  +++ L +    +RLG+G+   E+IR H +F+  +W+ + +  ++ P+NP ++G  D  +FD       +P       D +F
Sbjct:   45 EDEQPGSDDADVEKIDLGESNNPKAKP---SDFLFLKVIGKGSFGKVFLSKNKQE-DKFYAIKVLNKSAIRKRNEAKHIMAERNVLVQNVTHPFLVGLHYSFQTKDKLYFVLDYVNGGELFFHLQRERYFPESRARFYAAEIASAIGYLHGLQIIYRDLKPENILLDSKGHIVLTDFGLCKEGIDRSGTTSTFCGTPEYLAPEVLRKQDYDKSVDWWCLGAVLYEMMYGLPPFYSRDTAEMYD---------NILHKPLRLRTNISQSARHILEGLLQKDKTKRLGSGEGDFEDIRTHSFFRSINWQQLVARGIEPPYNPNVSGQLDLKHFDPEFVREPVPGSVGKSADSNF 383

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Nematostella
Match: EDO41166 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S521])

HSP 1 Score: 200.29 bits (508), Expect = 1.161e-56
Identity = 124/329 (37.69%), Postives = 185/329 (56.23%), Query Frame = 3

Query: 1476 SAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKS--YALKYMKKQYIVQT-KQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAIL-RDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKK-IGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFD-KFINESDI-PPDEN 2441
            S E+ N K E      FE++  LG GG+G+V LV  +   +K   +A+K +KK  I+++ K   H  +E+ IL   K  +I  L   F     +YL+ E   GGEL+  L R+ I  +D    F L+ +  AL +LH +GIVYRDLKPEN+L+  +G++KL DFG  K+ I     T TFCGT EY+APEI+    H  +VD+WS+G L Y++L G PPF A++  K  +  LKG     ++    +T +A   I++L +  P  RLG        I+ H +F+   WE + +  V+ PF P I+G +D S FD KF  ++ +  PD++
Sbjct:   49 SEETVNPKDEKVGPESFELLKVLGKGGYGKVFLVKKNHGHSKEKIFAMKVLKKAAIIRSQKDTAHTKAERNILECVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFLEDTAC-FYLSEISMALEHLHKQGIVYRDLKPENILLDANGHVKLTDFGLCKESIFENSLTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMYDMLTGTPPFCADNRKKTIDKILKG----KLIIPPYLTPEAKDFIRKLLKRHPQARLGGMAGDANPIKAHSFFRHICWEDLLAKKVEPPFRPSISGEEDVSQFDSKFTRQTPVDSPDDS 372

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Medaka
Match: prkg1 (protein kinase cGMP-dependent 1 [Source:NCBI gene;Acc:100049290])

HSP 1 Score: 627.861 bits (1618), Expect = 0.000e+0
Identity = 326/685 (47.59%), Postives = 448/685 (65.40%), Query Frame = 3

Query:  432 EAENHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRLGISGESSNHQ----RFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQK--INGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDD-ESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINES-DIPPDENSGWDKDF 2462
            E    ++L+   + E+D+K+  I+ LQ E+DK +SV+      +   ++       + R+KR  IS E +          TL  +PKS + K +I++AI++N  +  L+ SQ+ EI++CMY     ++  +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+VK L    LW +DR  FQTIMM+TGL +  +   FL+SV  F  L E  L K+ +++E   Y+ G+ IIRQG   D+FFII  G V VT++   NG+ + +R +  G++FGEKAL  E  RTA++ A +  T  L + R +F  LIG L  + +K +DD +++AK           E+ N    S +L DF I+ TLG GGFGRVELV    D  K++A+K +KK++IV T+QQ+H+ SEK I+ E  S +I RLY TF D+KY+Y+L E CLGGELW ILRDR  F+D  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL +ELL G+PPF   DPMK YN+ L+GI+   I    KIT  A +LI++LCR  P ERLGN KNG+++I+ HK+F+GF+WEG+K  T+  P  P +  P DTSNFD F  ++ D PPD+NSGWD DF
Sbjct:   17 ELRQRDALIDELELELDQKDELIQRLQNELDKYRSVIKPATQQVHKQNELHE----QQRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKENLKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMDFLKSVPTFHDLQEDILSKLADVLEETHYAGGEYIIRQGARGDTFFIISKGKVNVTREDLPNGEPVYLRSLGKGDWFGEKALQGEDIRTASVIAAEAVT-CLVIDRDSFKHLIGGLEDVSSKGHDDADAKAKY----------EAENAFFFSLNLADFNIIDTLGVGGFGRVELVQLKSDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKITKNAGNLIKKLCRDNPCERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPNVTSPVDTSNFDSFPEDNEDPPPDDNSGWDVDF 684

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BLAST of cGMP-dependent protein kinase vs. Ensembl Medaka
Match: ENSORLT00000001302.2 (cGMP-dependent protein kinase 2 [Source:NCBI gene;Acc:101165996])

HSP 1 Score: 613.224 bits (1580), Expect = 0.000e+0
Identity = 312/642 (48.60%), Postives = 421/642 (65.58%), Query Frame = 3

Query:  621 GISGESSNHQRF---------QTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKING--DEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQT--KEY------DDESRAKMSLSMHSRNSAESNNLKR---------ESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            G+S E  +   F          T     K+++ K++I +AI++N  L KL+P  + E+++CMYEK   E   VI+EG+ G  LYV  EG  EV ++ KL+G+M     FGELA+LYNCKRTA+VKA+    +W L+R  FQTIMM+T   R ++  TFL SV+L + L E KL +IV+ +EV+ +  G+ IIR+GEE ++FFII  G V VTQ   G     E++ +  G+YFGE+AL+ E  R+ANI   +  T+ L + R  F++++G    LQT  KEY       DE R  +  S  S +S E+  L R          +    + E++ATLG GGFGRVELV   KD   ++ALK +KK+++V T+QQ H+ SEKKIL +  SS+I RL+ TF DNKY+Y+L EVCLGGELW +LRD   F++   RFC+ CVLEA  YLHS GI+YRDLKPENLL+   GY+K+ DFGFAK+IGIG +TWTFCGTPEYVAPE+I+NK HDF  D WS+GIL +ELL G PPF  +DP+KIY M L GI++ +     +I  +   LI+RLC+  P+ER+GN KNGI +I+ HK+FQGF+WEG++   + SP   ++ GP D SNFD F   S+  PDE SGWDKDF
Sbjct:  131 GVSAEPPSADNFLWRYRPSSVSTARTVHKNSDTKRLINEAILSNDFLKKLEPQHMREMVDCMYEKVYSEGQLVIQEGDAGNYLYVLAEGLLEVIQNGKLLGEMHPGTAFGELAILYNCKRTATVKAVLQSHIWTLERQTFQTIMMQTTQARHQEYFTFLRSVSLLKQLPEEKLGRIVDCLEVEYFEKGEYIIREGEEGNTFFIIAKGQVTVTQSSEGFTQPQEIKTLGVGDYFGERALISEDVRSANIICNENDTQCLVVDRDNFNQMVGTYEELQTYLKEYVGELSKSDERRHFLPHSQQS-DSPEAQELSRLRERTARIPANQPFQELEVIATLGMGGFGRVELV-KLKDEESTFALKCIKKKHVVDTRQQQHIYSEKKILQQTNSSFIIRLFRTFRDNKYIYMLLEVCLGGELWTVLRDMSCFEEQTARFCIGCVLEAFDYLHSMGIIYRDLKPENLLLDADGYVKMADFGFAKQIGIGRKTWTFCGTPEYVAPEVIMNKGHDFGADCWSLGILVFELLTGNPPFSGSDPIKIYTMVLHGIDRVDFPK--RIGKRPDDLIRRLCKLNPVERIGNKKNGIMDIKKHKWFQGFNWEGLQGRKLPSPLKRELRGPMDHSNFDMFPPNSEEAPDELSGWDKDF 768

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BLAST of cGMP-dependent protein kinase vs. Ensembl Medaka
Match: prkg2 (protein kinase cGMP-dependent 2 [Source:NCBI gene;Acc:101158535])

HSP 1 Score: 593.964 bits (1530), Expect = 0.000e+0
Identity = 302/644 (46.89%), Postives = 419/644 (65.06%), Query Frame = 3

Query:  600 KARSKRLGISGE--SSNHQRFQ-TLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIE--VREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQ--------TKEYDDESRA-KMSLSMHSRNSAESN--------NLKRESFHLNDFEIVATLGFGGFGRVELV-VNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            + +  + G+S E  SS+ Q+F     + PK   VKK++  A+  N  L +L+  Q+ +++ECMYE++  +   VI++GE G  L+V  EG+ EV++  KL+  ++    FGELA+LYNC RTASV+A+     W LDR  FQ IM +T   R +  + FL SV+L  +L + KL KIV+ +EV+ Y  G+ IIR+GEE  +F+II  G VKVTQ     ++   +  +  G+YFGEKAL+ +  R+ANI A     E L + R+ F + +G+ N LQ        + + DD+ R  K S+S H   S            +L   S   +  E++ATLG GGFGRVELV V  +D T  +ALK +KK+++V+ KQ++H+ SE++IL E +S +I RLY TF D+KYVY+L E CLGGE+W++LRDR  FDD   +FC+ CV EA  YLH +G++YRDLKPENLL+   GY+KL DFGFAKKI  G +TWTFCGTPEYVAPEIILNK H+FSVDFW++GIL +ELL G+PPF  +D M IY   LKGIE+ +      I+ +   LI++LCR  P ERLGN KNGI +I+ H++F GF+WEG+K+ T+ SP   ++ GP D S FD +  + D PPDE SGWD+DF
Sbjct:  130 RRKGAKSGVSAEPTSSSLQKFSFEKARVPKDASVKKLLTDALNKNQYLRRLELQQIKDMVECMYERNYQQGECVIKQGEPGNHLFVLAEGKLEVFQHNKLLTWITVWTTFGELAILYNCTRTASVRAVNKVKTWALDREAFQNIMRRTAETRHEQYRNFLRSVSLLANLPDDKLSKIVDCLEVEYYDKGEYIIREGEEGSTFYIIAQGKVKVTQTTEAHKLPQIINALQKGDYFGEKALVSDDVRSANIIADDNGVECLVIDRETFDQTVGNFNELQKHLQGYVASLDRDDKKRHLKKSVSRHQSQSLSPGFMQLKDMVSLFTSSRPFHHLEVIATLGVGGFGRVELVKVKGEDVT--FALKAIKKKHVVENKQEEHIHSERRILAEARSPFIVRLYRTFKDSKYVYMLLEACLGGEVWSLLRDRGSFDDPTAKFCIGCVTEAFEYLHRKGVLYRDLKPENLLLDMEGYVKLVDFGFAKKIRSGQKTWTFCGTPEYVAPEIILNKGHNFSVDFWALGILVFELLTGSPPFSGSDQMTIYTFILKGIEKMDFPK--MISKRPEDLIRKLCRRNPSERLGNLKNGITDIKKHRWFTGFNWEGLKARTLASPLKRELKGPMDHSYFDSYPPDEDSPPDELSGWDEDF 769

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BLAST of cGMP-dependent protein kinase vs. Ensembl Medaka
Match: prkg1 (protein kinase cGMP-dependent 1 [Source:NCBI gene;Acc:100049290])

HSP 1 Score: 591.267 bits (1523), Expect = 0.000e+0
Identity = 308/649 (47.46%), Postives = 425/649 (65.49%), Query Frame = 3

Query:  447 ESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRL-GISGESSNHQRF--QTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQK--INGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDD-ESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKIN 2375
            E  +R  +R + ++  +I+EL+R++ K +SVL                  I  R++R  GIS E   HQ    Q L ++PKS+  K +I++AI++N  +  L+ SQ+ EI++CMY     ++  +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+VK L    LW +DR  FQTIMM+TGL +  +   FL+SV  F  L E  L K+ +++E   Y+ G+ IIRQG   D+FFII  G V VT++   NG+ + +R +  G++FGEKAL  E  RTA++ A +  T  L + R +F  LIG L  + +K +DD +++AK           E+ N    S +L DF I+ TLG GGFGRVELV    D  K++A+K +KK++IV T+QQ+H+ SEK I+ E  S +I RLY TF D+KY+Y+L E CLGGELW ILRDR  F+D  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL +ELL G+PPF   DPMK YN+ L+GI+   I    KIT  A +LI++LCR  P ERLGN KNG+++I+ HK+F+GF+WEG+K  T+  P  P ++
Sbjct:   16 EERIRDLERRLADREDEIQELKRKLHKCQSVLPSAQL-------------IGPRTRRAQGISAEPQTHQDLSRQALRRYPKSDWSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKENLKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMDFLKSVPTFHDLQEDILSKLADVLEETHYAGGEYIIRQGARGDTFFIISKGKVNVTREDLPNGEPVYLRSLGKGDWFGEKALQGEDIRTASVIAAEAVT-CLVIDRDSFKHLIGGLEDVSSKGHDDADAKAKY----------EAENAFFFSLNLADFNIIDTLGVGGFGRVELVQLKSDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKITKNAGNLIKKLCRDNPCERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPNVS 638

[Close]

BLAST of cGMP-dependent protein kinase vs. Ensembl Medaka
Match: prkg1 (protein kinase cGMP-dependent 1 [Source:NCBI gene;Acc:100049290])

HSP 1 Score: 588.186 bits (1515), Expect = 0.000e+0
Identity = 307/655 (46.87%), Postives = 427/655 (65.19%), Query Frame = 3

Query:  432 EAENHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRLGISGESSNHQ----RFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQK--INGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDD-ESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKIN 2375
            E    ++L+   + E+D+K+  I+ LQ E+DK +SV+      +   ++       + R+KR  IS E +          TL  +PKS + K +I++AI++N  +  L+ SQ+ EI++CMY     ++  +I+EG+ G  +YV ++G+ EV K+   +  M   K FGELA+LYNC RTA+VK L    LW +DR  FQTIMM+TGL +  +   FL+SV  F  L E  L K+ +++E   Y+ G+ IIRQG   D+FFII  G V VT++   NG+ + +R +  G++FGEKAL  E  RTA++ A +  T  L + R +F  LIG L  + +K +DD +++AK           E+ N    S +L DF I+ TLG GGFGRVELV    D  K++A+K +KK++IV T+QQ+H+ SEK I+ E  S +I RLY TF D+KY+Y+L E CLGGELW ILRDR  F+D  TRF  ACV+EA +YLHS+GI+YRDLKPENL++ + GY KL DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD S D+WS+GIL +ELL G+PPF   DPMK YN+ L+GI+   I    KIT  A +LI++LCR  P ERLGN KNG+++I+ HK+F+GF+WEG+K  T+  P  P ++
Sbjct:   17 ELRQRDALIDELELELDQKDELIQRLQNELDKYRSVIKPATQQVHKQNELHE----QQRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKENLKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMDFLKSVPTFHDLQEDILSKLADVLEETHYAGGEYIIRQGARGDTFFIISKGKVNVTREDLPNGEPVYLRSLGKGDWFGEKALQGEDIRTASVIAAEAVT-CLVIDRDSFKHLIGGLEDVSSKGHDDADAKAKY----------EAENAFFFSLNLADFNIIDTLGVGGFGRVELVQLKSDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDM--IEFPKKITKNAGNLIKKLCRDNPCERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPNVS 654

[Close]

BLAST of cGMP-dependent protein kinase vs. Planmine SMEST
Match: SMESG000007783.1 (SMESG000007783.1)

HSP 1 Score: 1399.42 bits (3621), Expect = 0.000e+0
Identity = 709/716 (99.02%), Postives = 711/716 (99.30%), Query Frame = 3

Query:  315 MGNENSKNLNIEYQRKLYGPDPKIXXXXXXXXXXXXXXXEAENHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRLGISGESSNHQRFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            MGNENSKNLNIEYQRKLYGPDPKIKLMNSSNKLNSVSNVEAE HESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTHSDLSFDHDSSSLNDIKARSKRLGISGESSNHQRFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENC+VIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIG+LNVLQ KEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYIT FCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGP DTSNFDKF NESDIPPDENSGWDKDF
Sbjct:    1 MGNENSKNLNIEYQRKLYGPDPKIKLMNSSNKLNSVSNVEAEKHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTHSDLSFDHDSSSLNDIKARSKRLGISGESSNHQRFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCYVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGELNVLQAKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITSFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPIDTSNFDKFTNESDIPPDENSGWDKDF 716

[Close]

BLAST of cGMP-dependent protein kinase vs. Planmine SMEST
Match: SMESG000008788.1 (SMESG000008788.1)

HSP 1 Score: 836.254 bits (2159), Expect = 0.000e+0
Identity = 408/677 (60.27%), Postives = 510/677 (75.33%), Query Frame = 3

Query:  432 EAENHESLLRAAKREIDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRLGISGESSNHQRFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            E EN  + L+  + E++EKN++IEELQREI+KL SVLDQT   L  +   SS+N I+ RSK+ G+SGES+  Q    L K+ KSN +K ++R++I+ N LL+ L   QV+E+IE MYE+     C+VI EGEEG+ LYVA+ G+FEV+K E+L+  +   +CFGELALLYNC+RTASVKAL    LWVLDR +FQ IMM+TG++RQ++L  FL+SV L + L E KL K+VEL+E+Q + +G+CIIRQGE AD FFII++G VKVTQ+ +G+E  +R ++ GEYFGEKALL    RTAN+YA    T+VLCLYR+ F ELIGDLN L+ K Y+DE       S       ++   K  +  L D E+V TLG GGFGRVELV  S D   +YALK MKK +IVQTKQQDHV+SEKKILLEC+S +ICRLY TF D K+VY+L EVCLGGELW  LRD+IHFDD IT+FCL CVLEA  YLHSRGI+YRDLKPENLL+  SGYLKLCDFGFAK+IGIG RTWTFCGTPEYV+PEIILNKSHDF+ D+WS+GILTYELL G PPF  NDPMKIY + LKGIE ++I HN +IT +A+S IQ LC++   ERLGNG  G+EEI+ HKYFQGFDWE ++   + SPF+PK+    D SNFD F +E ++PPDE SGWD++F
Sbjct:  187 EIENLRNQLKLTQEELNEKNIRIEELQREINKLTSVLDQTQISLESNDMISSVNSIQNRSKKQGVSGESNKDQTNLKLIKYKKSNSIKSLLRESILKNLLLSNLPTYQVDEMIEYMYERQIDRGCYVIIEGEEGDHLYVAESGDFEVWKAERLLCYLDGNRCFGELALLYNCRRTASVKALTDAKLWVLDREVFQAIMMRTGIQRQEELLRFLKSVPLLKGLPEIKLNKLVELLELQRHEEGECIIRQGESADCFFIIQSGSVKVTQRYDGEEQVIRTLTMGEYFGEKALLSAETRTANVYANSSVTDVLCLYRKPFLELIGDLNELKNKNYEDEKHLLSKSSSKVSICNDAEMEKLVNVKLKDLELVCTLGVGGFGRVELVRLSHDHQSTYALKCMKKYHIVQTKQQDHVISEKKILLECRSIFICRLYNTFKDVKFVYMLMEVCLGGELWTCLRDKIHFDDIITKFCLGCVLEAFDYLHSRGIIYRDLKPENLLITTSGYLKLCDFGFAKRIGIGKRTWTFCGTPEYVSPEIILNKSHDFTSDYWSVGILTYELLTGTPPFTGNDPMKIYTLILKGIEATDIFHNRRITFRASSFIQALCKFNAAERLGNGAGGLEEIKSHKYFQGFDWESIRKQDLVSPFHPKVTSSTDHSNFDDFQDEDELPPDEYSGWDEEF 863

[Close]

BLAST of cGMP-dependent protein kinase vs. Planmine SMEST
Match: SMESG000016927.1 (SMESG000016927.1)

HSP 1 Score: 610.142 bits (1572), Expect = 0.000e+0
Identity = 320/674 (47.48%), Postives = 441/674 (65.43%), Query Frame = 3

Query:  477 IDEKNLKIEELQREIDKLKSVLDQTXXXXXXXXXXXXXXXIKARSKRLGISGESSNHQ--RFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIE-----VREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLY--RQAFSELIGDLNVLQTKEYD---DESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            + +K+ KI EL  ++DK +SV   T    +      +    + R + LGIS E    +   FQ  + F K ++ K++I+++I+ N  +  L+ SQ+  I++CM       N  +I+EGE G  +YV ++G+  V K+   + +M N+  FGELA+LYNC RTA+V A+  C LW +DR  FQ+IMM+TGL + ++   FL+SV +F+ L E  L KI  ++E   Y++G  IIRQG + D+FFII +G V+VT+K   D+ +     +R+M  GE+FGEKAL +E  RTANI A   P  V CL   R+++ +LIGDL  LQ    D   D  +  +  S   +N A           L D  ++ATLG GGFGRVELV    +  K+YALK +KK +IV+T+QQ+H+M+E+ IL   +S +I RL+ TF D K++Y+L EVCLGGELW+ILRDR  FD+  T+F  ACV+EAL YLHSRGIVYRDLKPENLL+ N G+ K+ DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD   D WS+GIL +ELL G PPF A DPMKIYN+ LKGI+   I    KI+  A +LI++LCR  P ER+G GK G++E + H + + F+W+G+ S T+K P  P+IN P D SNFD++  E+++PPD+ SGWD+DF
Sbjct:   26 LQQKDEKIAELTSQLDKYQSVFSATQKQNNVQSGPHNN---QTRVRGLGISAEPQTAKIANFQP-SFFQKDSKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTKEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAAD-PAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDSPKEILGPSKEYKNLA-----------LKDLVVIATLGIGGFGRVELVQIGDNAKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDA--IEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 681

[Close]

BLAST of cGMP-dependent protein kinase vs. Planmine SMEST
Match: SMESG000016927.1 (SMESG000016927.1)

HSP 1 Score: 605.905 bits (1561), Expect = 0.000e+0
Identity = 311/630 (49.37%), Postives = 421/630 (66.83%), Query Frame = 3

Query:  606 RSKRLGISGESSNH-QRFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKINGDEIE-----VREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLY--RQAFSELIGDLNVLQTKEYD---DESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            R KR+ ISGES       + L  F K  + K++I+++I+ N  +  L+ SQ+  I++CM       N  +I+EGE G  +YV ++G+  V K+   + +M N+  FGELA+LYNC RTA+V A+  C LW +DR  FQ+IMM+TGL + ++   FL+SV +F+ L E  L KI  ++E   Y++G  IIRQG + D+FFII +G V+VT+K   D+ +     +R+M  GE+FGEKAL +E  RTANI A   P  V CL   R+++ +LIGDL  LQ    D   D  +  +  S   +N A           L D  ++ATLG GGFGRVELV    +  K+YALK +KK +IV+T+QQ+H+M+E+ IL   +S +I RL+ TF D K++Y+L EVCLGGELW+ILRDR  FD+  T+F  ACV+EAL YLHSRGIVYRDLKPENLL+ N G+ K+ DFGFAKKIG G +TWTFCGTPEYVAPEIILNK HD   D WS+GIL +ELL G PPF A DPMKIYN+ LKGI+   I    KI+  A +LI++LCR  P ER+G GK G++E + H + + F+W+G+ S T+K P  P+IN P D SNFD++  E+++PPD+ SGWD+DF
Sbjct:  179 RMKRIAISGESGTFISSPEVLPYFEKHLKTKELIKRSILENDFMKNLEQSQIKMIVDCMRPVKFAANSIIIKEGEVGSLVYVMEDGKVSVSKEGHHLREMKNETVFGELAILYNCTRTATVTAITDCKLWAIDRHSFQSIMMRTGLLKYEENLNFLKSVPIFKDLEESTLGKISGVLEETHYANGDYIIRQGTKGDTFFIISSGKVQVTRKNKPDDTKEKEQFIRQMQRGEWFGEKALKDEDLRTANIIAAD-PAGVDCLVLDRESYIQLIGDLTSLQRTYEDGVNDSPKEILGPSKEYKNLA-----------LKDLVVIATLGIGGFGRVELVQIGDNAKKTYALKQLKKHHIVETRQQEHIMNERNILYMVQSDFIVRLHRTFKDRKFLYMLMEVCLGGELWSILRDRSAFDENTTKFYTACVIEALHYLHSRGIVYRDLKPENLLLDNQGFCKITDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDTYADCWSLGILMFELLTGMPPFTAPDPMKIYNIILKGIDA--IEFPKKISKDAQNLIKKLCRDNPNERVGYGKGGVKECQKHLWLESFNWDGLLSHTIKPPIVPQINSPTDCSNFDEYPPETEMPPDDISGWDRDF 794

[Close]

BLAST of cGMP-dependent protein kinase vs. Planmine SMEST
Match: SMESG000005347.1 (SMESG000005347.1)

HSP 1 Score: 595.119 bits (1533), Expect = 0.000e+0
Identity = 306/627 (48.80%), Postives = 412/627 (65.71%), Query Frame = 3

Query:  600 KARSKRLGISGESSNHQRFQ--TLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNEIIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKKCFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKTFLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTGWVKVTQKIN--GDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLCLY--RQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFHLNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHVMSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHFDDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFAKKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAPPFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLGNGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFINESDIPPDENSGWDKDF 2462
            K R+KR  ISGES+ +      T+ +  K ++ K++IR AI +N  +  LDPSQ+ EI+ECM      E  ++I+EGE G  +Y  ++G  EV K   +I +M     FGELA+LYNC RTASV+A   C LW +DR  FQ+IMMKTGL +Q+D   FL+SV  F+ ++   L KI  ++    YS G  IIR+GE+  +F+II  G VKVT+K +   +E+ +R +  G +FGEKAL +E  RTA+I A + P+ V CL   R++++ LIGD+ V   K+Y DE +A+   S            K     L D  ++ TLG GGFGRVELV    D  +++ALK +KK +IV+T QQ+HVM+E+ IL+E  S +I +LY TF D +Y+Y+L EVCLGGE+W ILR+++ FDD  T+F  A V+ AL YLH +GIV+RDLKPEN L+   GY KL DFGFAKKIG   +TWTFCGTPEYVAPEIILNK HDF+VD WS+GIL YEL  G PPF ++DPMK YN+ LKGI+   I  + KI+  A SLI++LCR  P ERLG GK G+ E + H +F+GF+WEG+ S   K P  P++    D SNFD +  + + P ++ SGWDKDF
Sbjct:  249 KMRAKRNAISGESAKYLTTNGITMKRVEKPSKSKELIRSAIYDNDYMKHLDPSQITEIVECMSPVTYHEGSWIIQEGEIGSIVYALEDGLVEVTKSGAIIREMGPGTVFGELAILYNCTRTASVRATTECKLWAIDRQCFQSIMMKTGLRKQEDYIRFLKSVPTFQDMNMETLGKIAGVLGENHYSQGDYIIREGEKGATFYIIEKGRVKVTKKTSKSDEEVFIRHLDRGSWFGEKALRDEDVRTASIIA-ESPSGVDCLVLDRESYNLLIGDI-VNFDKQYPDEDKARRRAS------------KFPELALRDLCVITTLGVGGFGRVELVRIGNDDRRTFALKVLKKYHIVETHQQEHVMNERDILMEVDSEFIVKLYKTFKDRRYLYMLMEVCLGGEVWTILREKVSFDDATTKFYTASVILALEYLHRKGIVFRDLKPENCLLDEKGYCKLTDFGFAKKIGFARKTWTFCGTPEYVAPEIILNKGHDFAVDIWSLGILMYELFTGTPPFTSSDPMKTYNIILKGIQ--TIDFSSKISKHAQSLIKKLCRENPSERLGYGKLGVAEAQKHAWFEGFNWEGLLSKKTKPPIIPQVKSAVDVSNFDLYSPDEETPAEDISGWDKDF 859

The following BLAST results are available for this feature:

BLAST of cGMP-dependent protein kinase vs. Ensembl Human
BLAST of cGMP-dependent protein kinase vs. Ensembl Celegans
BLAST of cGMP-dependent protein kinase vs. Ensembl Fly
BLAST of cGMP-dependent protein kinase vs. Ensembl Zebrafish
BLAST of cGMP-dependent protein kinase vs. Ensembl Xenopus
BLAST of cGMP-dependent protein kinase vs. Ensembl Mouse
BLAST of cGMP-dependent protein kinase vs. UniProt/SwissProt
BLAST of cGMP-dependent protein kinase vs. TrEMBL
BLAST of cGMP-dependent protein kinase vs. Ensembl Cavefish
BLAST of cGMP-dependent protein kinase vs. Ensembl Sea Lamprey
BLAST of cGMP-dependent protein kinase vs. Ensembl Yeast
BLAST of cGMP-dependent protein kinase vs. Ensembl Nematostella
BLAST of cGMP-dependent protein kinase vs. Ensembl Medaka
BLAST of cGMP-dependent protein kinase vs. Planmine SMEST

BLAST of cGMP-dependent protein kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PRKG1	0.000e+0	47.22	protein kinase cGMP-dependent 1 [Source:HGNC Symbo...	[more]
PRKG1	0.000e+0	47.35	protein kinase cGMP-dependent 1 [Source:HGNC Symbo...	[more]
PRKG2	0.000e+0	49.00	protein kinase cGMP-dependent 2 [Source:HGNC Symbo...	[more]
PRKG2	0.000e+0	49.00	protein kinase cGMP-dependent 2 [Source:HGNC Symbo...	[more]
PRKG2	0.000e+0	47.50	protein kinase cGMP-dependent 2 [Source:HGNC Symbo...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
egl-4	0.000e+0	45.70	cGMP-dependent protein kinase egl-4 [Source:UniPr...	[more]
egl-4	0.000e+0	45.70	cGMP-dependent protein kinase egl-4 [Source:UniPr...	[more]
egl-4	0.000e+0	45.70	cGMP-dependent protein kinase egl-4 [Source:UniPr...	[more]
egl-4	0.000e+0	45.70	cGMP-dependent protein kinase egl-4 [Source:UniPr...	[more]
egl-4	0.000e+0	45.70	cGMP-dependent protein kinase egl-4 [Source:UniPr...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Pkg21D	0.000e+0	50.32	gene:FBgn0000442 transcript:FBtr0078042	[more]
for	0.000e+0	46.50	gene:FBgn0000721 transcript:FBtr0089310	[more]
for	0.000e+0	46.50	gene:FBgn0000721 transcript:FBtr0089312	[more]
for	0.000e+0	46.50	gene:FBgn0000721 transcript:FBtr0089304	[more]
for	0.000e+0	46.50	gene:FBgn0000721 transcript:FBtr0446099	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
prkg1b	0.000e+0	47.66	protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:...	[more]
prkg1b	0.000e+0	47.87	protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:...	[more]
prkg1a	0.000e+0	47.72	protein kinase cGMP-dependent 1a [Source:ZFIN;Acc:...	[more]
prkg1b	0.000e+0	45.67	protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:...	[more]
prkg2	0.000e+0	47.32	protein kinase cGMP-dependent 2 [Source:ZFIN;Acc:Z...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
camk4	0.000e+0	47.51	calcium/calmodulin-dependent protein kinase IV [So...	[more]
camk4	0.000e+0	47.51	calcium/calmodulin-dependent protein kinase IV [So...	[more]
camk4	0.000e+0	47.87	calcium/calmodulin-dependent protein kinase IV [So...	[more]
tnpo2	0.000e+0	46.21	transportin 2 [Source:Xenbase;Acc:XB-GENE-968452]	[more]
ptafr	0.000e+0	46.18	platelet activating factor receptor [Source:Xenbas...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Prkg1	0.000e+0	47.22	protein kinase, cGMP-dependent, type I [Source:MGI...	[more]
Prkg2	0.000e+0	49.15	protein kinase, cGMP-dependent, type II [Source:MG...	[more]
Prkg1	0.000e+0	47.35	protein kinase, cGMP-dependent, type I [Source:MGI...	[more]
Prkg2	0.000e+0	47.66	protein kinase, cGMP-dependent, type II [Source:MG...	[more]
Prkg1	1.249e-128	51.68	protein kinase, cGMP-dependent, type I [Source:MGI...	[more]

BLAST of cGMP-dependent protein kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|A8X6H1\|EGL4_CAEBR	0.000e+0	45.99	cGMP-dependent protein kinase egl-4 OS=Caenorhabdi...	[more]
sp\|O76360\|EGL4_CAEEL	0.000e+0	45.70	cGMP-dependent protein kinase egl-4 OS=Caenorhabdi...	[more]
sp\|Q03042\|KGP1_DROME	0.000e+0	50.32	cGMP-dependent protein kinase, isozyme 1 OS=Drosop...	[more]
sp\|P00516\|KGP1_BOVIN	0.000e+0	47.50	cGMP-dependent protein kinase 1 OS=Bos taurus OX=9...	[more]
sp\|P0C605\|KGP1_MOUSE	0.000e+0	47.35	cGMP-dependent protein kinase 1 OS=Mus musculus OX...	[more]

BLAST of cGMP-dependent protein kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1S3HLV4	0.000e+0	52.02	cGMP-dependent protein kinase OS=Lingula unguis OX...	[more]
A0A0X3NTH0	0.000e+0	50.49	cGMP-dependent protein kinase, isozyme 1 OS=Schist...	[more]
A0A0X3PBC4	0.000e+0	50.49	cGMP-dependent protein kinase, isozyme 1 OS=Schist...	[more]
V3Z912	0.000e+0	50.81	cGMP-dependent protein kinase OS=Lottia gigantea O...	[more]
A0A5N4A4B0	0.000e+0	49.93	Uncharacterized protein OS=Photinus pyralis OX=705...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
prkg1b	0.000e+0	47.43	protein kinase cGMP-dependent 1b [Source:ZFIN;Acc:...	[more]
ENSAMXT00000002114.2	0.000e+0	46.06	cGMP-dependent protein kinase 2-like [Source:NCBI ...	[more]
prkg2	0.000e+0	45.44	protein kinase cGMP-dependent 2 [Source:NCBI gene;...	[more]
prkg1a	0.000e+0	44.67	protein kinase cGMP-dependent 1a [Source:ZFIN;Acc:...	[more]
prkg2	5.434e-178	43.74	protein kinase cGMP-dependent 2 [Source:NCBI gene;...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000002200.1	3.700e-127	54.81	pep scaffold:Pmarinus_7.0:GL479132:31244:36905:-1 ...	[more]
ENSPMAT00000002201.1	1.224e-104	49.68	pep scaffold:Pmarinus_7.0:GL479132:31244:36797:-1 ...	[more]
ENSPMAT00000001814.1	7.096e-69	41.85	pep scaffold:Pmarinus_7.0:GL481074:830:17391:1 gen...	[more]
ENSPMAT00000006766.1	2.414e-55	34.53	pep scaffold:Pmarinus_7.0:GL478342:9725:27922:-1 g...	[more]
ENSPMAT00000008480.1	3.508e-51	34.19	pep scaffold:Pmarinus_7.0:GL482122:191709:206473:1...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
TPK2	3.833e-70	38.16	cAMP-dependent protein kinase catalytic subunit; p...	[more]
TPK1	9.534e-69	39.14	cAMP-dependent protein kinase catalytic subunit; p...	[more]
TPK3	2.323e-68	39.34	cAMP-dependent protein kinase catalytic subunit; p...	[more]
YPK1	5.087e-54	35.33	S/T protein kinase; phosphorylates, downregulates ...	[more]
YPK2	9.056e-53	36.22	Protein kinase similar to S/T protein kinase Ypk1p...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO38407	0.000e+0	50.22	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38399	0.000e+0	46.91	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35228	2.493e-76	42.24	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37800	5.468e-57	32.10	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO41166	1.161e-56	37.69	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of cGMP-dependent protein kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
prkg1	0.000e+0	47.59	protein kinase cGMP-dependent 1 [Source:NCBI gene;...	[more]
ENSORLT00000001302.2	0.000e+0	48.60	cGMP-dependent protein kinase 2 [Source:NCBI gene;...	[more]
prkg2	0.000e+0	46.89	protein kinase cGMP-dependent 2 [Source:NCBI gene;...	[more]
prkg1	0.000e+0	47.46	protein kinase cGMP-dependent 1 [Source:NCBI gene;...	[more]
prkg1	0.000e+0	46.87	protein kinase cGMP-dependent 1 [Source:NCBI gene;...	[more]

BLAST of cGMP-dependent protein kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000007783.1	0.000e+0	99.02	SMESG000007783.1	[more]
SMESG000008788.1	0.000e+0	60.27	SMESG000008788.1	[more]
SMESG000016927.1	0.000e+0	47.48	SMESG000016927.1	[more]
SMESG000016927.1	0.000e+0	49.37	SMESG000016927.1	[more]
SMESG000005347.1	0.000e+0	48.80	SMESG000005347.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30024190 ID=SMED30024190|Name=cGMP-dependent protein kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=2617bp
CACAGATATAACCCGCTGTCAGATTAGATGCACAGACCGATGAATTTTTG
GCAACATTACATTCGCAGCATCAGTTTAATTCATCATCATCATCATTCAG
AATTTACTGTAATTCATCTATCATTCTCGCTATCAGTTTACATGAGACTT
TCAAATTCGTCTGACTGAGTTTTGGAAAATTCATTTTGAAGATTTATCAC
TGATCACAGCTTCATATATTATTTCTACTCAATACAGCTTCATATAGTTA
GTGGACTCATTTAATGTGATCTTTGATTTATGAGAGACTGATTTTCAATA
AATGATAGTCAATTATGGGCAATGAAAACAGTAAAAATTTGAATATAGAA
TACCAGAGAAAACTATATGGACCAGATCCGAAAATCAAACTGATGAATTC
CTCAAACAAATTGAATTCCGTTAGCAATGTCGAAGCGGAAAACCATGAAA
GTCTTCTCCGTGCGGCTAAAAGAGAAATCGATGAGAAAAATTTAAAAATC
GAGGAGCTGCAAAGAGAAATAGACAAATTGAAATCCGTATTGGATCAGAC
TCACAGTGATCTCAGTTTTGATCATGATTCCAGCTCCTTAAATGATATAA
AAGCAAGATCCAAACGACTTGGAATATCTGGAGAATCTTCAAATCATCAA
AGATTTCAGACTTTAAATAAATTTCCAAAATCAAATGAGGTAAAAAAAGT
CATCCGTCAAGCCATCATGAACAACCATCTCCTCAATAAACTTGACCCTA
GTCAAGTAAATGAAATCATCGAATGCATGTATGAGAAACATGCTGTTGAA
AATTGTTTTGTAATAAGAGAAGGTGAAGAAGGTGAACAACTTTACGTAGC
TCAAGAAGGCGAATTTGAAGTTTATAAAGATGAAAAGTTAATTGGTAAAA
TGAGCAATAAAAAATGTTTTGGAGAATTAGCATTGCTATATAATTGTAAA
AGAACAGCCTCAGTTAAAGCTTTGAAAACTTGCACTTTATGGGTTCTCGA
TCGCACTATGTTTCAAACAATAATGATGAAAACGGGTTTAGAAAGACAAA
AAGATCTCAAAACGTTCTTGGAAAGTGTTAATTTATTTGAGCATCTTTCG
GAACGCAAATTATTGAAAATTGTTGAATTAGTTGAAGTTCAGAGTTATTC
AGATGGACAGTGCATTATTCGCCAAGGAGAAGAAGCTGATAGTTTTTTCA
TTATTCGTACTGGATGGGTTAAAGTTACCCAAAAAATAAACGGAGATGAA
ATTGAAGTTAGAGAAATGTCGTCTGGAGAATATTTTGGAGAAAAAGCTTT
ACTTGAAGAAGGAAAACGAACAGCGAATATTTATGCAGTTAAAGGTCCGA
CAGAGGTTTTGTGCCTTTACAGACAAGCATTTTCAGAGTTGATTGGAGAC
CTAAATGTGTTACAAACTAAAGAGTATGATGATGAGTCAAGAGCCAAAAT
GTCTTTGAGCATGCATTCAAGGAACTCAGCCGAAAGCAATAATCTGAAAC
GCGAAAGTTTCCATCTGAATGATTTTGAAATAGTTGCAACTTTAGGATTT
GGAGGATTTGGAAGAGTGGAATTGGTGGTCAATTCTAAGGATCCTACTAA
AAGTTATGCACTGAAATACATGAAAAAACAATATATCGTGCAAACGAAAC
AACAAGATCATGTTATGTCTGAAAAGAAGATTTTGCTAGAATGTAAATCA
TCATATATTTGCAGATTGTATGCCACATTCCATGATAACAAATACGTGTA
TTTGTTAACTGAAGTTTGTTTGGGCGGTGAACTATGGGCCATATTGAGAG
ATCGTATACATTTTGATGATTACATAACGCGTTTCTGCTTGGCTTGCGTA
CTGGAAGCCCTCAGTTATCTCCACTCCAGGGGCATCGTTTATCGAGATTT
GAAGCCGGAAAATCTGCTAGTTGGAAATTCAGGATATCTGAAATTGTGTG
ACTTTGGTTTTGCTAAGAAAATCGGGATCGGCGGAAGGACTTGGACATTT
TGTGGCACTCCAGAATACGTTGCCCCAGAAATTATACTCAATAAAAGCCA
TGATTTTTCTGTGGACTTTTGGTCCATTGGAATATTAACTTATGAACTAC
TAAACGGAGCCCCTCCTTTTGTTGCCAATGATCCGATGAAGATATATAAT
ATGACATTAAAAGGAATCGAACAATCAAACATCCTTCACAATTTCAAAAT
AACGATAAAAGCAGCATCTTTAATCCAGAGACTTTGTCGTTACCTCCCGA
TTGAACGTTTAGGAAATGGCAAAAATGGAATTGAGGAAATTAGAATGCAC
AAATATTTTCAGGGATTTGACTGGGAAGGAATGAAATCAATGACTGTAAA
GTCACCATTTAATCCAAAGATAAATGGACCAAAAGATACATCGAATTTCG
ACAAATTCATTAATGAATCTGATATTCCACCAGATGAAAATTCAGGATGG
GATAAAGATTTTTGATCCTTTTTACGACTTAATATTTCATTAGAAAATTA
TAAATTTTACAATGCCAAAAATTATGAAGTTATTTAAACAACTGTATTGC
ACAAAATATTATTTTCTTATTTGTTGATTACATCTGAATTGCATTTTAAA
ATAAAGCAAGATTTAAG

protein sequence of SMED30024190-orf-1

>SMED30024190-orf-1 ID=SMED30024190-orf-1|Name=SMED30024190-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=717bp
MGNENSKNLNIEYQRKLYGPDPKIKLMNSSNKLNSVSNVEAENHESLLRA
AKREIDEKNLKIEELQREIDKLKSVLDQTHSDLSFDHDSSSLNDIKARSK
RLGISGESSNHQRFQTLNKFPKSNEVKKVIRQAIMNNHLLNKLDPSQVNE
IIECMYEKHAVENCFVIREGEEGEQLYVAQEGEFEVYKDEKLIGKMSNKK
CFGELALLYNCKRTASVKALKTCTLWVLDRTMFQTIMMKTGLERQKDLKT
FLESVNLFEHLSERKLLKIVELVEVQSYSDGQCIIRQGEEADSFFIIRTG
WVKVTQKINGDEIEVREMSSGEYFGEKALLEEGKRTANIYAVKGPTEVLC
LYRQAFSELIGDLNVLQTKEYDDESRAKMSLSMHSRNSAESNNLKRESFH
LNDFEIVATLGFGGFGRVELVVNSKDPTKSYALKYMKKQYIVQTKQQDHV
MSEKKILLECKSSYICRLYATFHDNKYVYLLTEVCLGGELWAILRDRIHF
DDYITRFCLACVLEALSYLHSRGIVYRDLKPENLLVGNSGYLKLCDFGFA
KKIGIGGRTWTFCGTPEYVAPEIILNKSHDFSVDFWSIGILTYELLNGAP
PFVANDPMKIYNMTLKGIEQSNILHNFKITIKAASLIQRLCRYLPIERLG
NGKNGIEEIRMHKYFQGFDWEGMKSMTVKSPFNPKINGPKDTSNFDKFIN
ESDIPPDENSGWDKDF*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000026	gut
PLANA:0000070	intestinal phagocyte
PLANA:0000101	muscle cell
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR035014	STKc_cGK
IPR000961	AGC-kinase_C
IPR000595	cNMP-bd_dom
IPR000719	Prot_kinase_dom
IPR014710	RmlC-like_jellyroll
IPR002374	cGMP_dep_kinase
IPR008271	Ser/Thr_kinase_AS
IPR018488	cNMP-bd_CS
IPR017441	Protein_kinase_ATP_BS
IPR018490	cNMP-bd-like
IPR011009	Kinase-like_dom_sf

Vocabulary: **molecular function**
Term	Definition
GO:0005524	ATP binding
GO:0004674	protein serine/threonine kinase activity
GO:0004672	protein kinase activity
GO:0004692	cGMP-dependent protein kinase activity
GO:0000166	nucleotide binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0030553	cGMP binding

Vocabulary: **biological process**
Term	Definition
GO:0006468	protein phosphorylation
GO:0016310	phosphorylation

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 41..82
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 489..685 e-value: 4.2E-98 score: 329.9
None	No IPR available	GENE3D	G3DSA:3.30.200.20		coord: 401..696 e-value: 4.2E-98 score: 329.9
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 694..716
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 701..716
None	No IPR available	PANTHER	PTHR24353:SF90		coord: 37..716
None	No IPR available	PANTHER	PTHR24353	CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE	coord: 37..716
IPR000961	AGC-kinase, C-terminal	SMART	SM00133	pkinase_C_6	coord: 666..716 e-value: 4.4E-8 score: 42.8
IPR000961	AGC-kinase, C-terminal	PROSITE	PS51285	AGC_KINASE_CTER	coord: 666..716 score: 12.438
IPR000595	Cyclic nucleotide-binding domain	SMART	SM00100	cnmp_10	coord: 257..378 e-value: 1.2E-25 score: 101.2 coord: 139..252 e-value: 2.3E-19 score: 80.3
IPR000595	Cyclic nucleotide-binding domain	PFAM	PF00027	cNMP_binding	coord: 162..239 e-value: 2.6E-15 score: 56.3 coord: 276..360 e-value: 2.5E-20 score: 72.3
IPR000595	Cyclic nucleotide-binding domain	PROSITE	PS50042	CNMP_BINDING_3	coord: 257..377 score: 30.546
IPR000595	Cyclic nucleotide-binding domain	PROSITE	PS50042	CNMP_BINDING_3	coord: 139..254 score: 33.204
IPR000595	Cyclic nucleotide-binding domain	CDD	cd00038	CAP_ED	coord: 257..371 e-value: 1.77343E-28 score: 108.182
IPR000595	Cyclic nucleotide-binding domain	CDD	cd00038	CAP_ED	coord: 139..239 e-value: 1.34908E-23 score: 94.3149
IPR000719	Protein kinase domain	SMART	SM00220	serkin_6	coord: 404..665 e-value: 8.4E-79 score: 277.8
IPR000719	Protein kinase domain	PFAM	PF00069	Pkinase	coord: 405..665 e-value: 2.0E-63 score: 214.2
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 404..665 score: 42.873
IPR002374	cGMP-dependent kinase	PIRSF	PIRSF000559	cGMP-dep_kinase	coord: 4..716 e-value: 7.8E-275 score: 911.2
IPR014710	RmlC-like jelly roll fold	GENE3D	G3DSA:2.60.120.10		coord: 107..243 e-value: 9.5E-45 score: 153.5
IPR014710	RmlC-like jelly roll fold	GENE3D	G3DSA:2.60.120.10		coord: 244..381 e-value: 4.7E-35 score: 122.2
IPR018488	Cyclic nucleotide-binding, conserved site	PROSITE	PS00889	CNMP_BINDING_2	coord: 324..341
IPR018488	Cyclic nucleotide-binding, conserved site	PROSITE	PS00888	CNMP_BINDING_1	coord: 284..300
IPR018488	Cyclic nucleotide-binding, conserved site	PROSITE	PS00889	CNMP_BINDING_2	coord: 202..219
IPR008271	Serine/threonine-protein kinase, active site	PROSITE	PS00108	PROTEIN_KINASE_ST	coord: 524..536
IPR017441	Protein kinase, ATP binding site	PROSITE	PS00107	PROTEIN_KINASE_ATP	coord: 410..434
IPR035014	cGMP-dependent protein kinase, catalytic domain	CDD	cd05572	STKc_cGK	coord: 410..672 e-value: 1.59724E-143 score: 418.167
IPR018490	Cyclic nucleotide-binding-like	SUPERFAMILY	SSF51206	cAMP-binding domain-like	coord: 251..363
IPR018490	Cyclic nucleotide-binding-like	SUPERFAMILY	SSF51206	cAMP-binding domain-like	coord: 112..239
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 384..706