CKLF-like MARVEL transmembrane domain-containing protein 7

Overview
NameCKLF-like MARVEL transmembrane domain-containing protein 7
Smed IDSMED30024152
Length (bp)960
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of CKLF-like MARVEL transmembrane domain-containing protein 7 (SMED30024152) t-SNE clustered cells

Violin plots show distribution of expression levels for CKLF-like MARVEL transmembrane domain-containing protein 7 (SMED30024152) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of CKLF-like MARVEL transmembrane domain-containing protein 7 (SMED30024152) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for CKLF-like MARVEL transmembrane domain-containing protein 7 (SMED30024152) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30024152

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 12

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30024152h1SMcG0002968 Contig2990GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30024152h1SMcG0002968 PL06012A1G09smed_ncbi_20240424PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30024152h1SMcG0014637 Contig2990GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
nervous systemSMED30024152h1SMcG0002968 dd_Smed_v4_3096_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30024152h1SMcG0002968 dd_Smed_v4_3096_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30024152h1SMcG0002968 dd_Smed_v4_3096_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30024152h1SMcG0002968 dd_Smed_v4_3096_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neuronSMED30024152h1SMcG0002968 dd_Smed_v4_3096_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
parapharyngeal regionSMED30024152h1SMcG0002968 dd_Smed_v4_3096_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30024152h1SMcG0002968 dd_Smed_v4_3096_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30024152h1SMcG0002968 dd_Smed_v4_3096_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30024152h1SMcG0002968 dd_Smed_v4_3096_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. TrEMBL
Match: A0A4E0RCG1 (Marvel-containing potential lipid raft-associated protein OS=Fasciola hepatica OX=6192 GN=D915_004090 PE=4 SV=1)

HSP 1 Score: 83.1889 bits (204), Expect = 3.944e-15
Identity = 60/159 (37.74%), Postives = 90/159 (56.60%), Query Frame = 3 
Query:  123 VDYGFIRTVPFYLKVAEL-LCCIAIWICVACTKGFPIYGGGGFINFCSTLSFIMTLILFLLYLFAKIQVIPGPWVLIEVITILSSIVLFLICLLVAAISTDYXXXXXXXXXXXXXEMVIYIVEFVLRFKVMRTT-GFRFSAHMKSTDNTETGQNTVNNP 593
            V+  F++ +   LK+ E+ L CI I ICV+ T  +  Y  GG++NF + L+ I   + ++ YLF  I+ + GPW++IE  T++ S+V + I  +VAA  + +G GAIA A+ S   M +YI E V RF+V +   GFR          T TG  TV  P
Sbjct:   22 VNTAFVKNLSGILKLLEVVLSCIVI-ICVSATGSWSSYASGGWMNFVAALTLIFAALFYIFYLFNLIRRLRGPWIIIEFATLVVSVVFWFIAFIVAASMSRFGPGAIAAAVFSVAAMSVYIAELVTRFRVSKQAGGFRI---------TMTGVKTVTAP 170
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. TrEMBL
Match: A0A504YMW6 (Marvel-containing potential lipid raft-associated protein OS=Fasciola gigantica OX=46835 GN=FGIG_00890 PE=4 SV=1)

HSP 1 Score: 82.8037 bits (203), Expect = 6.728e-15
Identity = 59/159 (37.11%), Postives = 89/159 (55.97%), Query Frame = 3 
Query:  123 VDYGFIRTVPFYLKVAEL-LCCIAIWICVACTKGFPIYGGGGFINFCSTLSFIMTLILFLLYLFAKIQVIPGPWVLIEVITILSSIVLFLICLLVAAISTDYXXXXXXXXXXXXXEMVIYIVEFVLRFKVMRTT-GFRFSAHMKSTDNTETGQNTVNNP 593
            V+  F++ +   LK+ E+ L CI I ICV+ T  +  Y  GG++NF + L+ I   + ++ YLF  I+ + GPW++IE  T++ S+V + I  +VAA  + +G GAIA A+ S   M +YI E   RF+V +   GFR          T TG  TV  P
Sbjct:   22 VNTAFVKNLSGILKLLEVVLSCIVI-ICVSATGSWSSYASGGWMNFVAALTLIFAALFYIFYLFNLIRRLRGPWIIIEFATLVVSVVFWFIAFIVAASMSRFGAGAIAAAVFSVAAMSVYIAELATRFRVSKQAGGFRI---------TMTGVKTVTAP 170
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. TrEMBL
Match: C1L435 (Hypotheticial protein OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 78.9518 bits (193), Expect = 9.012e-14
Identity = 49/138 (35.51%), Postives = 82/138 (59.42%), Query Frame = 3 
Query:  123 VDYGFIRTVPFYLKVAELLCCIAIWICVACTKGFPIYGGGGFINFCSTLSFIMTLILFLLYLFAKIQVIPGPWVLIEVITILSSIVLFLICLLVAAISTDYXXXXXXXXXXXXXEMVIYIVEFVLRFKV-MRTTGFRF 533
            ++ GF+R++   LK+ ++L    + ICVA T  + IY  GG++NF ++++ I   + ++ YLF  I+ +PGPW++IE   +L     + I L+VAA +   G GAIA A+ S + + +YI E   RF+   R  GF +
Sbjct:   25 INVGFVRSLSGILKLCQILLSCIVLICVAATTAWSIYPSGGWVNFVASVTLICASVFYIFYLFNLIRKLPGPWIIIEFSVLLICTFFWFITLIVAAANNGKGSGAIAAAVFSAVALGVYITELATRFRCERRGNGFHY 162
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. TrEMBL
Match: G4VKT0 (Putative marvel-containing potential lipid raft-associated protein OS=Schistosoma mansoni OX=6183 GN=Smp_046290 PE=4 SV=1)

HSP 1 Score: 77.411 bits (189), Expect = 5.904e-13
Identity = 53/159 (33.33%), Postives = 85/159 (53.46%), Query Frame = 3 
Query:  123 VDYGFIRTVPFYLKVAELLCCIAIWICVACTKGFPIYGGGGFINFCSTLSFIMTLILFLLYLFAKIQVIPGPWVLIEVITILSSIVLFLICLLVAAISTDYXXXXXXXXXXXXXEMVIYIVEFVLRFKV-MRTTGFRFSAHMKSTDNTETGQNTVNNPS 596
            ++ GF+R++   LK+ ++L    + ICVA T  + I+  GG++NF +  + I   + ++ YLF  I+ +PGPW++IE   +L     + I L+VAA     G GAIA A+ S I + +YI E   RF+   R  GF  +     T +   G  T   P+
Sbjct:   25 INVGFVRSLSGILKLCQILLSCIVLICVAATSYWSIHSSGGWVNFVAATTLICAAVFYIFYLFNLIRKLPGPWIIIEFSVLLICTFFWFITLIVAAAHHSKGAGAIAAAVFSAIALAVYITELATRFRCERRGNGFIITMTGVMTTHATHGPPTFAQPA 183
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. TrEMBL
Match: Q5DBL8 (SJCHGC06191 protein OS=Schistosoma japonicum OX=6182 GN=EWB00_011407 PE=2 SV=1)

HSP 1 Score: 77.0258 bits (188), Expect = 6.993e-13
Identity = 49/136 (36.03%), Postives = 81/136 (59.56%), Query Frame = 3 
Query:  123 VDYGFIRTVPFYLKVAELLCCIAIWICVACTKGFPIYGGGGFINFCSTLSFIMTLILFLLYLFAKIQVIPGPWVLIEVITILSSIVLFLICLLVAAISTDYXXXXXXXXXXXXXEMVIYIVEFVLRFK-VMRTTGF 527
            ++ GF+R++   LK+ ++L    + ICVA T  + IY  GG++NF ++++ I   + ++ YLF  I+ +PGPW++IE   +L     + I L+VAA +   G GAIA A+ S + + +YI E   RF+   R  GF
Sbjct:   25 INVGFVRSLSGILKLCQILLSCIVLICVAATTAWSIYPSGGWVNFVASVTLICASVFYIFYLFNLIRKLPGPWIIIEFSVLLICTFFWFITLIVAAANNGKGSGAIAAAVFSAVALGVYITELATRFRCERRGNGF 160
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. Planmine SMEST
Match: SMESG000001041.1 (SMESG000001041.1)

HSP 1 Score: 310.842 bits (795), Expect = 1.355e-107
Identity = 167/169 (98.82%), Postives = 168/169 (99.41%), Query Frame = 3 
Query:  111 MCLKVDYGFIRTVPFYLKVAELLCCIAIWICVACTKGFPIYGGGGFINFCSTLSFIMTLILFLLYLFAKIQVIPGPWVLIEVITILSSIVLFLICLLVAAISTDYXXXXXXXXXXXXXEMVIYIVEFVLRFKVMRTTGFRFSAHMKSTDNTETGQNTVNNPSGPYIIGA 617
            MCLKVDYGFIRTVPFYLKVAELLCCIAIWICVACTKGFPIYGGGGFINFCSTLSFIMTLILFLLYLFAKIQVIPGPWVLIEVITILSSIVLFL+CLLVAAISTDYG GAIATAIISGIEMVIYIVEFVLRFKVMRTTGFRFSAHMKSTDNTETGQNTVNNPSGPYIIGA
Sbjct:    1 MCLKVDYGFIRTVPFYLKVAELLCCIAIWICVACTKGFPIYGGGGFINFCSTLSFIMTLILFLLYLFAKIQVIPGPWVLIEVITILSSIVLFLVCLLVAAISTDYGSGAIATAIISGIEMVIYIVEFVLRFKVMRTTGFRFSAHMKSTDNTETGQNTVNNPSGPYIIGA 169
[Close]
BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. Planmine SMEST
Match: SMESG000017269.1 (SMESG000017269.1)

HSP 1 Score: 84.7297 bits (208), Expect = 2.522e-19
Identity = 63/141 (44.68%), Postives = 89/141 (63.12%), Query Frame = 3 
Query:  135 FIRTVPFYLKVAELLCCIAIWICVACTKGFPIYGGGGFINFCSTLSFIMTLILFLLYLFAKIQVIPGPWVLIEVITILSSIVLFLICLLVAAISTDYXXXXXXXXXXXXXEMVIYIVEFVLRFKVMRTTGFRFSAHMKSTD 557
            FI ++P  LK+ EL+  I IWICV  T  F   G GG+INF +T++FI T++ F+LYL   I  +PGPW+LIE ++IL S+    I +LV A S  +GGGAIA  +   +  V+Y VE  LRF++ R+ G+ F+A     D
Sbjct:   27 FIISLPGILKIIELVVDIIIWICVGSTPFFGYGGNGGYINFAATITFIFTIVFFILYLSNIIYRLPGPWILIECVSILLSVFFLTIAILVGAFSHKFGGGAIAATVFCALNDVVYGVEMFLRFRITRSGGWTFTATAIDGD 167
The following BLAST results are available for this feature:
BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4E0RCG13.944e-1537.74Marvel-containing potential lipid raft-associated ... [more]
A0A504YMW66.728e-1537.11Marvel-containing potential lipid raft-associated ... [more]
C1L4359.012e-1435.51Hypotheticial protein OS=Schistosoma japonicum OX=... [more]
G4VKT05.904e-1333.33Putative marvel-containing potential lipid raft-as... [more]
Q5DBL86.993e-1336.03SJCHGC06191 protein OS=Schistosoma japonicum OX=61... [more]
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CKLF-like MARVEL transmembrane domain-containing protein 7 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000001041.11.355e-10798.82SMESG000001041.1[more]
SMESG000017269.12.522e-1944.68SMESG000017269.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30024152 ID=SMED30024152|Name=CKLF-like MARVEL transmembrane domain-containing protein 7|organism=Schmidtea mediterranea sexual|type=transcript|length=960bp
TCTTAAAATTATACTTAATTTAACAGTATTACTTCATTGTAAATATTTAG
TATTTTGAAATTGAAGGAAATTAATTTTTACTTTTTGATATTATAAAATT
CTTTATCAAAATGTGTCTCAAAGTTGATTATGGTTTTATTCGAACTGTTC
CGTTTTATTTGAAAGTAGCAGAATTGCTTTGTTGCATTGCTATATGGATA
TGTGTCGCTTGCACTAAAGGTTTTCCTATATATGGCGGCGGTGGATTTAT
TAATTTCTGTTCAACTCTCTCTTTCATTATGACATTAATATTGTTTCTGC
TATATCTATTTGCGAAGATTCAAGTTATCCCCGGTCCTTGGGTGTTAATA
GAAGTCATAACAATTTTATCATCAATAGTACTATTTTTAATTTGTTTACT
CGTAGCGGCCATATCAACCGATTATGGTGGTGGTGCCATTGCTACAGCTA
TAATATCTGGAATCGAGATGGTTATTTATATTGTTGAATTCGTTCTTCGA
TTTAAAGTAATGCGTACCACGGGATTCCGATTTTCCGCTCACATGAAATC
AACCGATAATACTGAGACGGGCCAAAACACAGTCAACAATCCGTCAGGTC
CATACATTATCGGCGCCTAACTTAAATAAAACAATTTACATTTCACATTT
ATGTGCTTTTGCTTGTGACTACAGAAATTTCAGAAATTCTACATATCAAT
TAAAACAGATAATTATTAAAGGTGGTTGAAATTGAATTCTTTTTCTATCG
TTTTTATCTGAATATTTACCAGTTGTCCTAAATTAGATTTCTACATTCCA
TTTCATAATCGTTTTCTTTTATTTCTAAAAATATTTCTTCTTTATTTTTA
GTGAAAAAAATTTATTCTTTTTTGCTTTGATATATAACGAATGAGTGATA
TTTTTTATTGATTATAAAATTGTTTGTTATTATTGTTAACAAATAAAAAC
TTTTGATAAT
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protein sequence of SMED30024152-orf-1

>SMED30024152-orf-1 ID=SMED30024152-orf-1|Name=SMED30024152-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=170bp
MCLKVDYGFIRTVPFYLKVAELLCCIAIWICVACTKGFPIYGGGGFINFC
STLSFIMTLILFLLYLFAKIQVIPGPWVLIEVITILSSIVLFLICLLVAA
ISTDYGGGAIATAIISGIEMVIYIVEFVLRFKVMRTTGFRFSAHMKSTDN
TETGQNTVNNPSGPYIIGA*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000034epidermis
PLANA:0000070intestinal phagocyte
PLANA:0000099neuron
PLANA:0003117parapharyngeal cell
Vocabulary: INTERPRO
TermDefinition
IPR008253Marvel
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availablePANTHERPTHR22776MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEINcoord: 5..135
NoneNo IPR availableTMHMMTMhelixcoord: 79..101
NoneNo IPR availableTMHMMTMhelixcoord: 45..67
NoneNo IPR availableTMHMMTMhelixcoord: 13..35
NoneNo IPR availableTMHMMTMhelixcoord: 105..127
IPR008253Marvel domainPROSITEPS51225MARVELcoord: 9..135
score: 12.678