Soluble guanylate cyclase gcy
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30024148 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 4
Homology
BLAST of Soluble guanylate cyclase gcy vs. TrEMBL
Match: G4LU96 (Soluble guanylate cyclase gcy, putative OS=Schistosoma mansoni OX=6183 GN=Smp_211220 PE=4 SV=1) HSP 1 Score: 115.546 bits (288), Expect = 5.813e-24 Identity = 94/328 (28.66%), Postives = 152/328 (46.34%), Query Frame = 2 Query: 155 ILLETKDFYLIDKPAGVSLF-------RSKPKGDPNYVSKCSEFAVQDIIPDL---CSKLEIESQFAN-----------------ISSELPWNYSGLFVFSKNKQHYETSKKFFKTSSYGMGSGYISQSYRCLCWNRPINNQLDTIPFSFRKFYPDKTDYQNSIIYKSKHSSKNEINTK-----SVWTKHIGHDVVSYGNLENDKIVLIDVKCNSSYRGLVQLYLLHQGSIVVGEFLQASRLVTDGVNNDICILPPEKANAAKPLPIQFRQRLGTFGRELNKLPLHIHCIELLVP----SNDRKPKTESYLSESKFNFNSRPGITINW 1030 I+ TK F +IDKP +S++ + +P S S+ + D +P L + LE E Q + I LP YSGL + +N+++ ++KF+KT+ G + + Q +CW +P Q+ + P SF P + ++ S NEI+ + K + H ++S G+ K L+ ++ NS YRGL ++YLL++G VVGE QASRLV G++ +LPP K +P++ RQ LG L +P+HIH L +P N +SY+ + F ++ G I + Sbjct: 785 IVALTKHFVVIDKPPNLSVWGHSLASREAITMINPKLCSA-SDLGINDCLPQLNTIITSLEQEQQDTSNDDSSNLSRSVEIPKLYIIESLPAAYSGLILLGRNEKYTNAARKFYKTAMLGGTTWDLYQKLLIVCWGKP--QQIQSKPKSF----PIAAYALHDHLHVGYRPSPNEISKSLKLKGVILEKLVHHTILSEGS---KKSSLVKLETNSLYRGLPEVYLLYEGCTVVGETFQASRLVNTGISP--IVLPPSKIRLNYSIPLEQRQILGQSNNNLEDIPVHIHRSHLYLPIPFYMNSSNLCIKSYVKKPSHLFKTKSGTMIQY 1100
BLAST of Soluble guanylate cyclase gcy vs. TrEMBL
Match: A0A5K4F0L8 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1) HSP 1 Score: 113.62 bits (283), Expect = 7.466e-24 Identity = 93/323 (28.79%), Postives = 150/323 (46.44%), Query Frame = 2 Query: 155 ILLETKDFYLIDKPAGVSLF-------RSKPKGDPNYVSKCSEFAVQDIIPDL---CSKLEIESQFAN-----------------ISSELPWNYSGLFVFSKNKQHYETSKKFFKTSSYGMGSGYISQSYRCLCWNRPINNQLDTIPFSFRKFYPDKTDYQNSIIYKSKHSSKNEINTK-----SVWTKHIGHDVVSYGNLENDKIVLIDVKCNSSYRGLVQLYLLHQGSIVVGEFLQASRLVTDGVNNDICILPPEKANAAKPLPIQFRQRLGTFGRELNKLPLHIHCIELLVP----SNDRKPKTESYLSESKFNFNSRPG 1015 I+ TK F +IDKP +S++ + +P S S+ + D +P L + LE E Q + I LP YSGL + +N+++ ++KF+KT+ G + + Q +CW +P Q+ + P SF P + ++ S NEI+ + K + H ++S G+ K L+ ++ NS YRGL ++YLL++G VVGE QASRLV G++ +LPP K +P++ RQ LG L +P+HIH L +P N +SY+ + F ++ G Sbjct: 94 IVALTKHFVVIDKPPNLSVWGHSLASREAISMINPKLCS-ASDLGINDCLPQLNTIITSLEQEQQDTSNNDSSNLSRSVEIPKLYIIESLPAAYSGLILLGRNEKYTNAARKFYKTAMLGGTTWDLYQKLLIVCWGKP--QQIQSKPKSF----PIAAYALHDHLHVGYRPSPNEISKSLKLKGVILEKLVHHTILSEGS---KKSSLVKLETNSLYRGLPEVYLLYEGCTVVGETFQASRLVNTGISP--IVLPPSKIRLNYSIPLEQRQILGQSNNNLEDIPVHIHRSHLYLPIPFYMNSSNLCIKSYVKKPSHLFKTKSG 404
BLAST of Soluble guanylate cyclase gcy vs. TrEMBL
Match: A0A564Z2D7 (Uncharacterized protein (Fragment) OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS11744 PE=4 SV=1) HSP 1 Score: 108.997 bits (271), Expect = 2.627e-22 Identity = 98/383 (25.59%), Postives = 167/383 (43.60%), Query Frame = 2 Query: 143 IFDNILLETKDFYLIDKPAGVSLFRSKPKGDP---NYVSKCSEFAVQDIIPDLCSKLE----------------------------IESQFAN---------ISSELPWNYSGLFVFSKNKQHYETSKKFFKTSSYGMGSGYISQSYRCLCWNRPINNQLDTIPFSFRKFYPDKTDYQNSIIYKSKHSSKNEINTKS-----VWTKHIGHDVVSYGNLENDKIVLIDVKCNSSYRGLVQLYLLHQGSIVVGEFLQASRLVTD-GVNNDICILPPEKANAAKPLPIQFRQRLGTFGRELNKLPLHIHCIELLVP---SNDRKPKTESYLSESKFN--FNSRPGITI----NWDHSLKLNVC----SYHSVPDYYSEIMKHFNIS 1114 + ++ ++F +IDKPA +S++ P S+ +V++ +P L L E F+N I LP YSGL + + +K + + ++ F++ ++ G I Q++ CW P + + F + K S+ Y+ + ++I ++S + KH+GH V+S G+ + LI + CNS Y GL ++YLLH+G V+GE +QASRLV + GV +LPP A P+ + + G +P HIH +LL+P S K + S +S F FN++ G I + + K NVC + S+P Y+ ++ +S Sbjct: 68 LVSRVVAYGRNFLVIDKPANLSVWGHAYSASPLISGATSQSPPLSVRECLPHLRDVLSGSNPFSLTNPSDSSRPLSVLVSGKGNKHSERPFSNAWAPPSEIFIVEALPAAYSGLILLATSKAYADFARSFYRDATKNTFPGSIYQTFHIACWGHPSRDHAENERFPIAVY---KASESISVAYRP---TDDKITSRSNKRGALVFKHVGHSVLSRGSNQGSG-SLIKLVCNSCYAGLPEVYLLHEGCEVIGEDIQASRLVENAGVP---MVLPPAMAKLGAPIRTELLKIFGVKNIPRAAIPTHIHRSQLLIPSPLSTSSKVEMFSRRHQSPFGWIFNTQEGSPILSWKTYPANEKKNVCFLSAASPSLPSYFVRTLEKLGLS 440
BLAST of Soluble guanylate cyclase gcy vs. TrEMBL
Match: A0A183R269 (Uncharacterized protein OS=Schistosoma rodhaini OX=6188 PE=4 SV=1) HSP 1 Score: 107.071 bits (266), Expect = 4.197e-22 Identity = 70/210 (33.33%), Postives = 108/210 (51.43%), Query Frame = 2 Query: 329 ISSELPWNYSGLFVFSKNKQHYETSKKFFKTSSYGMGSGYISQSYRCLCWNRPINNQLDTIPFSFRKFYPDKTDYQNSIIYKSKHSSKNEINTK-----SVWTKHIGHDVVSYGNLENDKIVLIDVKCNSSYRGLVQLYLLHQGSIVVGEFLQASRLVTDGVNNDICILPPEKANAAKPLPIQFRQRLGTFGRELNKLPLHIHCIELLVP 943 I LP YSGL + +N+++ ++KF+KT+ G + + Q +CW +P Q+ + P SF P + ++ S NEI+ + K + H ++S G K LI ++ NS YRGL ++YLL++G VVGE QASRLV G++ +LPP K +P++ RQ LG L +P+HIH L +P Sbjct: 57 IIESLPAAYSGLILLGRNEKYTNAARKFYKTAMLGGTTWDLYQKLLIVCWGKP--QQIQSKPTSF----PIAAYALHDRLHVGYRPSPNEISKSLKLKGVILEKLVHHTILSEGP---KKSSLIKLETNSLYRGLPEVYLLYEGCTVVGETFQASRLVNTGISP--IVLPPSKIRLNYSIPLEQRQILGQSDTNLEDIPVHIHRSHLYLP 255
BLAST of Soluble guanylate cyclase gcy vs. TrEMBL
Match: A0A4Z2CWT5 (Soluble guanylate cyclase 88E isoform 3 OS=Schistosoma japonicum OX=6182 GN=EWB00_006867 PE=4 SV=1) HSP 1 Score: 109.768 bits (273), Expect = 4.378e-22 Identity = 84/298 (28.19%), Postives = 144/298 (48.32%), Query Frame = 2 Query: 155 ILLETKDFYLIDKPAGVSLFRSKPKG-------DPNYVSKCSEFAVQDIIPDL----------------------CSKLEIESQFANISSELPWNYSGLFVFSKNKQHYETSKKFFKTSSYGMGSGYISQSYRCLCWNRPINNQLDTIPFSFRKFYPDKTDYQNSIIYKSKHSSKNEINTK-----SVWTKHIGHDVVSYGNLENDKIVLIDVKCNSSYRGLVQLYLLHQGSIVVGEFLQASRLVTDGVNNDICILPPEKANAAKPLPIQFRQRLGTFGRE-LNKLPLHIHCIELLVP 943 I+ TK F +IDKP +S++ +P VS S+ + D +P L C+ +E+ + I LP YSGL + +N+++ ++KF+K+++ G + Q +CW +P + D+IP SF P + N + S NEI+ + K + H ++S G+ D L+ ++ NS++RGL ++YLL++G VVGE QASRL+ G++ +LPP + +P++ R+ LG + L+ +P+HIH L +P Sbjct: 628 IVAITKYFVVIDKPPNLSVWGHSLTSREAISVINPKLVST-SDLGINDCLPQLSNIITSLEKEQHHNFNNDLSNSCTTVEVPKLY--IIEALPAAYSGLILLGRNEKYTNAARKFYKSATLGGTPWELYQKLLIVCWGKP--QKKDSIPASF----PIASYRVNDHLRVGYRPSPNEISGSLIKKGVILQKSVQHTILSEGH---DNCSLLKLETNSTFRGLPEVYLLYEGCAVVGETFQASRLLNTGLSP--VVLPPSQIRLNYSIPLKHRRILGQSNADNLDFIPVHIHRSHLYLP 911
BLAST of Soluble guanylate cyclase gcy vs. Planmine SMEST
Match: SMESG000045324.1 (SMESG000045324.1) HSP 1 Score: 767.689 bits (1981), Expect = 0.000e+0 Identity = 374/375 (99.73%), Postives = 374/375 (99.73%), Query Frame = 2 Query: 2 MNLNKSLRTLKISECNSIFRGSIFRYLSQFKANEIDFEDRKQNFINTIFDNILLETKDFYLIDKPAGVSLFRSKPKGDPNYVSKCSEFAVQDIIPDLCSKLEIESQFANISSELPWNYSGLFVFSKNKQHYETSKKFFKTSSYGMGSGYISQSYRCLCWNRPINNQLDTIPFSFRKFYPDKTDYQNSIIYKSKHSSKNEINTKSVWTKHIGHDVVSYGNLENDKIVLIDVKCNSSYRGLVQLYLLHQGSIVVGEFLQASRLVTDGVNNDICILPPEKANAAKPLPIQFRQRLGTFGRELNKLPLHIHCIELLVPSNDRKPKTESYLSESKFNFNSRPGITINWDHSLKLNVCSYHSVPDYYSEIMKHFNISLPLN 1126 MNLNKSLRTLKISECNSIFRGSIFRYLSQFKANEIDFEDRKQNFINTIFDNILLETKDFYLIDKPAGVSLFRSKPKGDPNYVSKCSEFAVQDIIPDLCSKLEIESQFANISSELPWNYSGLFVFSKNKQHYETSKKFFKTSSYGMGSGYISQSYRCLCWNRPINNQLDTIPFSFRKFYPDKTD QNSIIYKSKHSSKNEINTKSVWTKHIGHDVVSYGNLENDKIVLIDVKCNSSYRGLVQLYLLHQGSIVVGEFLQASRLVTDGVNNDICILPPEKANAAKPLPIQFRQRLGTFGRELNKLPLHIHCIELLVPSNDRKPKTESYLSESKFNFNSRPGITINWDHSLKLNVCSYHSVPDYYSEIMKHFNISLPLN Sbjct: 1 MNLNKSLRTLKISECNSIFRGSIFRYLSQFKANEIDFEDRKQNFINTIFDNILLETKDFYLIDKPAGVSLFRSKPKGDPNYVSKCSEFAVQDIIPDLCSKLEIESQFANISSELPWNYSGLFVFSKNKQHYETSKKFFKTSSYGMGSGYISQSYRCLCWNRPINNQLDTIPFSFRKFYPDKTDNQNSIIYKSKHSSKNEINTKSVWTKHIGHDVVSYGNLENDKIVLIDVKCNSSYRGLVQLYLLHQGSIVVGEFLQASRLVTDGVNNDICILPPEKANAAKPLPIQFRQRLGTFGRELNKLPLHIHCIELLVPSNDRKPKTESYLSESKFNFNSRPGITINWDHSLKLNVCSYHSVPDYYSEIMKHFNISLPLN 375 The following BLAST results are available for this feature:
BLAST of Soluble guanylate cyclase gcy vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Soluble guanylate cyclase gcy vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Soluble guanylate cyclase gcy vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Soluble guanylate cyclase gcy vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Soluble guanylate cyclase gcy vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Soluble guanylate cyclase gcy vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Soluble guanylate cyclase gcy vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Soluble guanylate cyclase gcy vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Soluble guanylate cyclase gcy vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Soluble guanylate cyclase gcy vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Soluble guanylate cyclase gcy vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Soluble guanylate cyclase gcy vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Soluble guanylate cyclase gcy vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Soluble guanylate cyclase gcy vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30024148 ID=SMED30024148|Name=Soluble guanylate cyclase gcy|organism=Schmidtea mediterranea sexual|type=transcript|length=1189bpback to top protein sequence of SMED30024148-orf-1 >SMED30024148-orf-1 ID=SMED30024148-orf-1|Name=SMED30024148-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=376bp MNLNKSLRTLKISECNSIFRGSIFRYLSQFKANEIDFEDRKQNFINTIFDback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|