SCO cytochrome c oxidase assembly protein 1

Overview


Name	SCO cytochrome c oxidase assembly protein 1
Smed ID	SMED30023957
Length (bp)	1009

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of SCO cytochrome c oxidase assembly protein 1 (SMED30023957) t-SNE clustered cells

Violin plots show distribution of expression levels for SCO cytochrome c oxidase assembly protein 1 (SMED30023957) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of SCO cytochrome c oxidase assembly protein 1 (SMED30023957) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30023957

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X1 cell	SMED30023957	SMESG000073891.1	SmedASXL_011303	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
nervous system	SMED30023957	SMESG000073891.1	dd_Smed_v4_9334_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30023957	SMESG000073891.1	dd_Smed_v4_9334_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

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Homology

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BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Human
Match: SCO1 (SCO cytochrome c oxidase assembly protein 1 [Source:HGNC Symbol;Acc:HGNC:10603])

HSP 1 Score: 202.601 bits (514), Expect = 1.727e-62
Identity = 86/167 (51.50%), Postives = 121/167 (72.46%), Query Frame = 3

Query:  276 GDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYN 776
            G P +GG F L  H G ++T  D+  +WLL+YFG+ HCPD+CPE+LEKM  +VD+ID+ + +P++ P+F+S+DP+RDT  ++A Y+KEFS K++GLTG   E+  + ++Y+V+Y  G KDE  DY+VDH IIMYLIGP G+FL Y+G  K   EI ASI + MR Y 
Sbjct:  132 GKPLLGGPFSLTTHTGERKTDKDYLGQWLLIYFGFTHCPDVCPEELEKMIQVVDEIDSITTLPDLTPLFISIDPERDTKEAIANYVKEFSPKLVGLTGTREEVDQVARAYRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKRKGEIAASIATHMRPYR 298

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BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Human
Match: SCO2 (SCO cytochrome c oxidase assembly protein 2 [Source:HGNC Symbol;Acc:HGNC:10604])

HSP 1 Score: 174.096 bits (440), Expect = 5.226e-52
Identity = 67/164 (40.85%), Postives = 114/164 (69.51%), Query Frame = 3

Query:  294 GDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNVLV 785
            GDF L+DH+G  R + DF+ +W+L+YFG+ HCPDICP++LEK+  +V +++    +P + P+F++VDP+RD   ++A+Y+++F  +++GLTG   ++   + SY+V+Y  G KDE  DY+VDH+I +YL+ P G F  YYG ++S ++I  S+   M  +  ++
Sbjct:  102 GDFHLLDHRGRARCKADFRGQWVLMYFGFTHCPDICPDELEKLVQVVRQLEAEPGLPPVQPVFITVDPERDDVEAMARYVQDFHPRLLGLTGSTKQVAQASHSYRVYYNAGPKDEDQDYIVDHSIAIYLLNPDGLFTDYYGRSRSAEQISDSVRRHMAAFRSVL 265

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Query:  294 GDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNVLV 785
            GDF L+DH+G  R + DF+ +W+L+YFG+ HCPDICP++LEK+  +V +++    +P + P+F++VDP+RD   ++A+Y+++F  +++GLTG   ++   + SY+V+Y  G KDE  DY+VDH+I +YL+ P G F  YYG ++S ++I  S+   M  +  ++
Sbjct:  102 GDFHLLDHRGRARCKADFRGQWVLMYFGFTHCPDICPDELEKLVQVVRQLEAEPGLPPVQPVFITVDPERDDVEAMARYVQDFHPRLLGLTGSTKQVAQASHSYRVYYNAGPKDEDQDYIVDHSIAIYLLNPDGLFTDYYGRSRSAEQISDSVRRHMAAFRSVL 265

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Query:  294 GDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNVLV 785
            GDF L+DH+G  R + DF+ +W+L+YFG+ HCPDICP++LEK+  +V +++    +P + P+F++VDP+RD   ++A+Y+++F  +++GLTG   ++   + SY+V+Y  G KDE  DY+VDH+I +YL+ P G F  YYG ++S ++I  S+   M  +  ++
Sbjct:  102 GDFHLLDHRGRARCKADFRGQWVLMYFGFTHCPDICPDELEKLVQVVRQLEAEPGLPPVQPVFITVDPERDDVEAMARYVQDFHPRLLGLTGSTKQVAQASHSYRVYYNAGPKDEDQDYIVDHSIAIYLLNPDGLFTDYYGRSRSAEQISDSVRRHMAAFRSVL 265

[Close]

Query:  294 GDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNVLV 785
            GDF L+DH+G  R + DF+ +W+L+YFG+ HCPDICP++LEK+  +V +++    +P + P+F++VDP+RD   ++A+Y+++F  +++GLTG   ++   + SY+V+Y  G KDE  DY+VDH+I +YL+ P G F  YYG ++S ++I  S+   M  +  ++
Sbjct:  102 GDFHLLDHRGRARCKADFRGQWVLMYFGFTHCPDICPDELEKLVQVVRQLEAEPGLPPVQPVFITVDPERDDVEAMARYVQDFHPRLLGLTGSTKQVAQASHSYRVYYNAGPKDEDQDYIVDHSIAIYLLNPDGLFTDYYGRSRSAEQISDSVRRHMAAFRSVL 265

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BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Celegans
Match: sco-1 (SCO (Yeast Suppressor of Cytochrome Oxidase deficiency) homolog [Source:UniProtKB/TrEMBL;Acc:Q17557])

HSP 1 Score: 145.976 bits (367), Expect = 5.541e-41
Identity = 63/172 (36.63%), Postives = 105/172 (61.05%), Query Frame = 3

Query:  270 SYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIK--DEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNV 779
            + G   IGG+++L++  G      + +  WLL+YFG+ +CPDICP+++EKM  +V+ I+   +   I+P+F+SVDP+RD+   V +Y  EFS K+ G TG   ++  + ++++V++  G +   +  DY+VDH +IMYLI P G F  YYG  +  +EI   I  ++  Y  
Sbjct:  131 TAGKARIGGEWELMNTDGKMEGSQELRGNWLLMYFGFTNCPDICPDEIEKMVKVVEIIEAKKDATPIVPVFISVDPERDSVARVKEYCSEFSNKLRGFTGTTEQVNKVAKTFRVYHSQGPRTNKQEDDYIVDHTVIMYLIDPSGQFHDYYGQNRKAEEIANVIEMKVLKYQA 302

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BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Fly
Match: Scox (gene:FBgn0262467 transcript:FBtr0079052)

HSP 1 Score: 196.438 bits (498), Expect = 3.883e-61
Identity = 89/225 (39.56%), Postives = 141/225 (62.67%), Query Frame = 3

Query:  114 SKSLLPKSRRKLMIV--IGCTGFSFFIYGLAQYKNRQAEESYKLIFDIIDSSNNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNVL 782
            +K   P S R L ++  +G  G  F +Y  ++    + +E  + +           G   IGG ++LVD +G  R   DF  KWLL+YFG+ HCPDICP++LEKM+ +VD+++ +   P + PIF++VDP+RD+   VAKY+KEFS K++GLTG   +I+ + ++++V++  G +DE  DY+VDH IIMYL+ P G+F+ YYG  +  D+  ASI+  +  +N +
Sbjct:   31 TKGKGPISWRSLAVIGALGAGGVGFMLYVKSEKDEARMKERQRQL-----------GKAAIGGSWELVDSQGAVRKSEDFLGKWLLIYFGFTHCPDICPDELEKMAAVVDEVEKSPQTPAVQPIFITVDPERDSKEVVAKYVKEFSPKLLGLTGTVEQIRKVCKAFRVYFSAGPRDEDNDYIVDHTIIMYLVNPDGEFVDYYGQNRDKDQCVASILVNIAKWNSM 244

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BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Zebrafish
Match: sco1 (SCO cytochrome c oxidase assembly protein 1 [Source:ZFIN;Acc:ZDB-GENE-140909-1])

HSP 1 Score: 192.2 bits (487), Expect = 1.669e-58
Identity = 91/192 (47.40%), Postives = 128/192 (66.67%), Query Frame = 3

Query:  201 QYKNRQAEESYKLIFDIIDSSNNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYN 776
            +Y  R+ EE ++           S G P +GG F L+DH        DF  +WLL+YFG+ HCPDICP++LEKM   VD+IDN   +P++ P+ +S+DP+RDTP ++A Y+K+FS K+IGLTG   +I+ ++++Y+V+Y  G KDE  DY+VDH IIMYL+GP G FL+YYG  K   EI +SI S MR + 
Sbjct:  130 KYFKREKEELFE------KERTKSIGKPALGGPFSLLDHNNKPSRSEDFLGRWLLIYFGFTHCPDICPDELEKMIEAVDEIDNIDTLPDVTPLLISIDPERDTPEALAAYVKDFSPKLIGLTGTTAQIEQVSRAYRVYYSQGPKDEDNDYIVDHTIIMYLVGPDGQFLEYYGQNKKSSEIASSIASYMRKHK 315

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BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Zebrafish
Match: sco1 (SCO cytochrome c oxidase assembly protein 1 [Source:ZFIN;Acc:ZDB-GENE-140909-1])

HSP 1 Score: 192.2 bits (487), Expect = 1.838e-58
Identity = 91/192 (47.40%), Postives = 128/192 (66.67%), Query Frame = 3

Query:  201 QYKNRQAEESYKLIFDIIDSSNNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYN 776
            +Y  R+ EE ++           S G P +GG F L+DH        DF  +WLL+YFG+ HCPDICP++LEKM   VD+IDN   +P++ P+ +S+DP+RDTP ++A Y+K+FS K+IGLTG   +I+ ++++Y+V+Y  G KDE  DY+VDH IIMYL+GP G FL+YYG  K   EI +SI S MR + 
Sbjct:  130 KYFKREKEELFE------KERTKSIGKPALGGPFSLLDHNNKPSRSEDFLGRWLLIYFGFTHCPDICPDELEKMIEAVDEIDNIDTLPDVTPLLISIDPERDTPEALAAYVKDFSPKLIGLTGTTAQIEQVSRAYRVYYSQGPKDEDNDYIVDHTIIMYLVGPDGQFLEYYGQNKKSSEIASSIASYMRKHK 315

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BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Zebrafish
Match: sco2 (SCO cytochrome c oxidase assembly protein 2 [Source:NCBI gene;Acc:606683])

HSP 1 Score: 173.711 bits (439), Expect = 6.757e-52
Identity = 70/160 (43.75%), Postives = 116/160 (72.50%), Query Frame = 3

Query:  294 GDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNY 773
            GDF L+DH G +RT+ DF   W+L+YFG+ HCPDICP++LEK++ +V  +D + ++P++ P+F++VDP+RD  +++A+Y+K+F  +++GLTG   E+K   + ++V+   G KDE GDY+VDH+I++YL+ P G F+ YY   K+  +I  SI + M+ +
Sbjct:  114 GDFHLLDHTGQRRTKRDFLGHWVLLYFGFTHCPDICPDELEKLTSVVHILDKDPSLPSVQPLFITVDPERDDVSAMARYVKDFHPRLVGLTGSAEEVKQAGRDFRVYASNGPKDEDGDYIVDHSIVIYLVNPDGLFIDYYNRMKNDTQIAESIRNHMKTF 273

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Query:  294 GDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNY 773
            GDF L+DH G +RT+ DF   W+L+YFG+ HCPDICP++LEK++ +V  +D + ++P++ P+F++VDP+RD  +++A+Y+K+F  +++GLTG   E+K   + ++V+   G KDE GDY+VDH+I++YL+ P G F+ YY   K+  +I  SI + M+ +
Sbjct:  114 GDFHLLDHTGQRRTKRDFLGHWVLLYFGFTHCPDICPDELEKLTSVVHILDKDPSLPSVQPLFITVDPERDDVSAMARYVKDFHPRLVGLTGSAEEVKQAGRDFRVYASNGPKDEDGDYIVDHSIVIYLVNPDGLFIDYYNRMKNDTQIAESIRNHMKTF 273

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BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Xenopus
Match: sirt4 (sirtuin 4 [Source:Xenbase;Acc:XB-GENE-948981])

HSP 1 Score: 202.986 bits (515), Expect = 1.799e-63
Identity = 93/215 (43.26%), Postives = 141/215 (65.58%), Query Frame = 3

Query:  129 PKSRRKLMIVIGCTGFSFFIYGLAQYKNRQAEESYKLIFDIIDSSNNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNY 773
            P S + L + +   G    + G+ +Y  ++ E+  +           S G P +GG F L+DH G  +T  D+  +W+L+YFG+ HCPDICPE++EKM L+VD+ID    +PN+ P+F+++DP+RD+ ++VA Y+KEFS K+IGLTG   +I+ + ++Y+V++ +G KDE  DY+VDH IIMYL+ P G F+ YYG  K   EI +SI S MRN+
Sbjct:   42 PVSWKSLALTVALGGA--LMAGM-KYLKKEKEDKLE------QERKRSLGKPLLGGPFSLIDHNGQPKTDKDYLGQWVLLYFGFTHCPDICPEEIEKMILVVDEIDKIPTLPNLTPLFITIDPERDSKDAVANYVKEFSPKLIGLTGSSEQIEKVAKAYRVYFSSGPKDEDNDYIVDHTIIMYLLAPDGSFVDYYGQNKRNAEISSSIASHMRNF 247

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BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Xenopus
Match: sec24a (SEC24 homolog A, COPII coat complex component [Source:Xenbase;Acc:XB-GENE-987688])

HSP 1 Score: 176.792 bits (447), Expect = 6.848e-53
Identity = 72/161 (44.72%), Postives = 113/161 (70.19%), Query Frame = 3

Query:  294 GDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYN 776
            GDF LVDH G  RT+   ++ W+L+YFG+ HCPDICP++LEK+S  V  +D +  +P+++P+F++VDP+RD+  ++AKY+ +F  +++GLTG   ++K + ++Y+V+Y TG KDE  DY+VDH I++YL+ P G F  YY   K+  EI  S+   M+ Y 
Sbjct:  109 GDFSLVDHTGQPRTKSFLRDNWVLLYFGFTHCPDICPDELEKLSSAVSLLDKDPALPHVLPVFITVDPERDSVAALAKYVSDFHPRLLGLTGSTEQVKEVAKAYRVYYSTGPKDEDNDYIVDHTIMIYLLNPDGLFTDYYSRGKTDQEIADSVRRHMQTYT 269

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BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Mouse
Match: Sco1 (SCO1 cytochrome c oxidase assembly protein [Source:MGI Symbol;Acc:MGI:106362])

HSP 1 Score: 202.216 bits (513), Expect = 9.810e-63
Identity = 92/215 (42.79%), Postives = 138/215 (64.19%), Query Frame = 3

Query:  129 PKSRRKLMIVIGCTGFSFFIYGLAQYKNRQAEESYKLIFDIIDSSNNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNY 773
            P S + L +     G    + G+  +K  + E     + ++    + S G P +GG F L  H G  +T  D+  +W+L+YFG+ HCPDICPE+LEKM  +V++ID+  ++PN+ P+F+++DP+RDT  ++A Y+KEFS K++GLTG   EI  + ++Y+V+Y  G KDE  DY+VDH IIMYLIGP G+FL Y+G  K   EI  SI + MR++
Sbjct:   75 PVSWKSLALTFAIGGS--LLAGMKYFKKEKIESVS--LLELEKQRHRSIGKPLLGGPFSLTTHNGEPKTDKDYLGQWVLIYFGFTHCPDICPEELEKMIEVVEEIDSIPSLPNLTPLFITIDPERDTKEAIATYVKEFSPKLVGLTGTKEEIDGVARAYRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKKKAEIAGSIAAHMRSH 285

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BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Mouse
Match: Sco1 (SCO1 cytochrome c oxidase assembly protein [Source:MGI Symbol;Acc:MGI:106362])

HSP 1 Score: 199.134 bits (505), Expect = 1.225e-61
Identity = 85/170 (50.00%), Postives = 122/170 (71.76%), Query Frame = 3

Query:  264 NNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNY 773
            + S G P +GG F L  H G  +T  D+  +W+L+YFG+ HCPDICPE+LEKM  +V++ID+  ++PN+ P+F+++DP+RDT  ++A Y+KEFS K++GLTG   EI  + ++Y+V+Y  G KDE  DY+VDH IIMYLIGP G+FL Y+G  K   EI  SI + MR++
Sbjct:  111 HRSIGKPLLGGPFSLTTHNGEPKTDKDYLGQWVLIYFGFTHCPDICPEELEKMIEVVEEIDSIPSLPNLTPLFITIDPERDTKEAIATYVKEFSPKLVGLTGTKEEIDGVARAYRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKKKAEIAGSIAAHMRSH 280

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BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Mouse
Match: Sco2 (SCO2 cytochrome c oxidase assembly protein [Source:MGI Symbol;Acc:MGI:3818630])

HSP 1 Score: 176.792 bits (447), Expect = 2.634e-53
Identity = 85/251 (33.86%), Postives = 146/251 (58.17%), Query Frame = 3

Query:   45 NFSKYIKFLRFS--KILNINQSFYCSKSLL--PKSRRKLMIVIGCTGFSFFIYGLAQYKNRQAEESYKLIFDIIDSSNNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNVLV 785
              S++   LR S  + L+ N   +  +     P  R +L+I    T       G A    R  +E ++           + G     GDF L+DHKG  R + DF+ +W+L+YFG+ HCPDICP++LEK+  +V K++   ++P + P+F++VDP+RD   ++A+Y++EF  +++GLTG   ++ + +++Y+V+Y  G KDE  DY+VDH+I +YL+ P G F  YYG ++S ++I  SI   +  ++ ++
Sbjct:   12 KLSQFKPLLRISGGETLHRNSRHWAGQGQRQGPGLRTRLLI----TALFGAGLGWAWLAARAEKEQWRQQQRTEALRQAAVGQ----GDFSLLDHKGQPRCKADFRGQWVLMYFGFTHCPDICPDELEKLVQVVRKLEAEPDLPLVQPVFITVDPERDDVAAMARYVQEFHPRLLGLTGSTEQVAHASRNYRVYYSAGPKDEDQDYIVDHSIAIYLLNPDGLFTDYYGRSRSAEQIVESIRRHIAAFHSVL 254

[Close]

Query:   45 NFSKYIKFLRFS--KILNINQSFYCSKSLL--PKSRRKLMIVIGCTGFSFFIYGLAQYKNRQAEESYKLIFDIIDSSNNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNVLV 785
              S++   LR S  + L+ N   +  +     P  R +L+I    T       G A    R  +E ++           + G     GDF L+DHKG  R + DF+ +W+L+YFG+ HCPDICP++LEK+  +V K++   ++P + P+F++VDP+RD   ++A+Y++EF  +++GLTG   ++ + +++Y+V+Y  G KDE  DY+VDH+I +YL+ P G F  YYG ++S ++I  SI   +  ++ ++
Sbjct:   12 KLSQFKPLLRISGGETLHRNSRHWAGQGQRQGPGLRTRLLI----TALFGAGLGWAWLAARAEKEQWRQQQRTEALRQAAVGQ----GDFSLLDHKGQPRCKADFRGQWVLMYFGFTHCPDICPDELEKLVQVVRKLEAEPDLPLVQPVFITVDPERDDVAAMARYVQEFHPRLLGLTGSTEQVAHASRNYRVYYSAGPKDEDQDYIVDHSIAIYLLNPDGLFTDYYGRSRSAEQIVESIRRHIAAFHSVL 254

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. UniProt/SwissProt
Match: sp|O75880|SCO1_HUMAN (Protein SCO1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=SCO1 PE=1 SV=1)

HSP 1 Score: 202.601 bits (514), Expect = 8.293e-62
Identity = 86/167 (51.50%), Postives = 121/167 (72.46%), Query Frame = 3

Query:  276 GDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYN 776
            G P +GG F L  H G ++T  D+  +WLL+YFG+ HCPD+CPE+LEKM  +VD+ID+ + +P++ P+F+S+DP+RDT  ++A Y+KEFS K++GLTG   E+  + ++Y+V+Y  G KDE  DY+VDH IIMYLIGP G+FL Y+G  K   EI ASI + MR Y 
Sbjct:  132 GKPLLGGPFSLTTHTGERKTDKDYLGQWLLIYFGFTHCPDVCPEELEKMIQVVDEIDSITTLPDLTPLFISIDPERDTKEAIANYVKEFSPKLVGLTGTREEVDQVARAYRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKRKGEIAASIATHMRPYR 298

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. UniProt/SwissProt
Match: sp|Q5SUC9|SCO1_MOUSE (Protein SCO1 homolog, mitochondrial OS=Mus musculus OX=10090 GN=Sco1 PE=1 SV=1)

HSP 1 Score: 199.134 bits (505), Expect = 8.566e-61
Identity = 85/170 (50.00%), Postives = 122/170 (71.76%), Query Frame = 3

Query:  264 NNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNY 773
            + S G P +GG F L  H G  +T  D+  +W+L+YFG+ HCPDICPE+LEKM  +V++ID+  ++PN+ P+F+++DP+RDT  ++A Y+KEFS K++GLTG   EI  + ++Y+V+Y  G KDE  DY+VDH IIMYLIGP G+FL Y+G  K   EI  SI + MR++
Sbjct:  111 HRSIGKPLLGGPFSLTTHNGEPKTDKDYLGQWVLIYFGFTHCPDICPEELEKMIEVVEEIDSIPSLPNLTPLFITIDPERDTKEAIATYVKEFSPKLVGLTGTKEEIDGVARAYRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKKKAEIAGSIAAHMRSH 280

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. UniProt/SwissProt
Match: sp|A1A4J8|SCO1_BOVIN (Protein SCO1 homolog, mitochondrial OS=Bos taurus OX=9913 GN=SCO1 PE=2 SV=1)

HSP 1 Score: 199.519 bits (506), Expect = 1.106e-60
Identity = 86/171 (50.29%), Postives = 120/171 (70.18%), Query Frame = 3

Query:  264 NNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYN 776
            + S G P +GG F L  H G  +T  D+  +W+L+YFG+ HCPDICPE+LEKM  +VD+ID+   +PN+ P+F+++DP+RDT  ++A Y+KEFS K+IGLTG   EI  + ++++V+Y  G KDE  DY+VDH IIMYLIGP G+FL Y+G  K   EI  SI + MR + 
Sbjct:  132 HRSIGKPLLGGPFSLTTHTGEPKTDKDYLGQWVLIYFGFTHCPDICPEELEKMIQVVDEIDSIPTLPNLTPLFITIDPERDTKEAIANYVKEFSPKLIGLTGTKEEIDQVARAFRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKKNAEIAGSIAAHMRTHR 302

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. UniProt/SwissProt
Match: sp|A6H784|SCO2_BOVIN (Protein SCO2 homolog, mitochondrial OS=Bos taurus OX=9913 GN=SCO2 PE=2 SV=1)

HSP 1 Score: 177.178 bits (448), Expect = 1.738e-52
Identity = 69/164 (42.07%), Postives = 116/164 (70.73%), Query Frame = 3

Query:  294 GDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNVLV 785
            GDF L+DH+G  R + DF+ +W+L+YFG+ HCPDICP++LEK+  +V +++    +P + P+F++VDP+RDT  ++A+Y+++F  +++GLTG   +I  +++SY+V+Y  G KDE  DY+VDH+I +YL+ P G F  YY  A+S ++I  S+   M  +  ++
Sbjct:  102 GDFSLLDHRGRVRCKADFRGQWVLLYFGFTHCPDICPDELEKLVQVVRQLEAEPGLPPVQPLFITVDPERDTVAAMARYVQDFHPRLLGLTGSAEQIAQVSRSYRVYYSAGPKDEDQDYIVDHSIAIYLLSPDGLFTDYYSRARSAEQITDSVRRHMAAFRSVL 265

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. UniProt/SwissProt
Match: sp|Q8VCL2|SCO2_MOUSE (Protein SCO2 homolog, mitochondrial OS=Mus musculus OX=10090 GN=Sco2 PE=1 SV=1)

HSP 1 Score: 176.792 bits (447), Expect = 1.842e-52
Identity = 85/251 (33.86%), Postives = 146/251 (58.17%), Query Frame = 3

Query:   45 NFSKYIKFLRFS--KILNINQSFYCSKSLL--PKSRRKLMIVIGCTGFSFFIYGLAQYKNRQAEESYKLIFDIIDSSNNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNVLV 785
              S++   LR S  + L+ N   +  +     P  R +L+I    T       G A    R  +E ++           + G     GDF L+DHKG  R + DF+ +W+L+YFG+ HCPDICP++LEK+  +V K++   ++P + P+F++VDP+RD   ++A+Y++EF  +++GLTG   ++ + +++Y+V+Y  G KDE  DY+VDH+I +YL+ P G F  YYG ++S ++I  SI   +  ++ ++
Sbjct:   12 KLSQFKPLLRISGGETLHRNSRHWAGQGQRQGPGLRTRLLI----TALFGAGLGWAWLAARAEKEQWRQQQRTEALRQAAVGQ----GDFSLLDHKGQPRCKADFRGQWVLMYFGFTHCPDICPDELEKLVQVVRKLEAEPDLPLVQPVFITVDPERDDVAAMARYVQEFHPRLLGLTGSTEQVAHASRNYRVYYSAGPKDEDQDYIVDHSIAIYLLNPDGLFTDYYGRSRSAEQIVESIRRHIAAFHSVL 254

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BLAST of SCO cytochrome c oxidase assembly protein 1 vs. TrEMBL
Match: A0A452IUW6 (SCO cytochrome c oxidase assembly protein 1 OS=Gopherus agassizii OX=38772 GN=SCO1 PE=4 SV=1)

HSP 1 Score: 213.001 bits (541), Expect = 9.870e-64
Identity = 92/170 (54.12%), Postives = 124/170 (72.94%), Query Frame = 3

Query:  267 NSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYN 776
             + G P +GG F LVDH+G  RT  DF  +W+L+YFG+ HCPDICPE+LEKM L VD+ID   ++PN+ P+F+++DP+RDT  +VA+Y+KEFS K+IGLTG   +I+ + ++Y+V+Y +G KDE  DY+VDH IIMYLIGP G F+ YYG  K   EI  SI + MR Y 
Sbjct:  108 RALGKPLLGGPFSLVDHQGQPRTNRDFLGQWVLIYFGFTHCPDICPEELEKMILAVDEIDQIPSLPNVTPLFITIDPERDTGEAVARYVKEFSPKLIGLTGTKEQIEQVARAYRVYYSSGPKDEDNDYIVDHTIIMYLIGPDGGFVDYYGQNKKNSEIATSIAAHMRQYK 277

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. TrEMBL
Match: A0A4D9DQT7 (EMILIN-1 OS=Platysternon megacephalum OX=55544 GN=DR999_PMT18256 PE=4 SV=1)

HSP 1 Score: 212.616 bits (540), Expect = 1.353e-63
Identity = 92/170 (54.12%), Postives = 125/170 (73.53%), Query Frame = 3

Query:  267 NSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYN 776
             + G P +GG F LVDH+G  RT  DF  +W+L+YFG+ HCPDICPE+LEKM L VD+ID   ++PN+ P+F+++DP+RDT  +VA+Y+KEFS K+IGLTG   +I+ ++++Y+V+Y +G KDE  DY+VDH IIMYLIGP G F+ YYG  K   EI  SI + MR Y 
Sbjct:  107 RAVGKPLLGGPFSLVDHQGQPRTNRDFLGQWVLIYFGFTHCPDICPEELEKMILAVDEIDKIPSLPNVTPLFITIDPERDTGEAVARYVKEFSPKLIGLTGTKEQIEQVSRAYRVYYSSGPKDEDHDYIVDHTIIMYLIGPDGGFVDYYGQNKKNSEIATSIAAHMRQYK 276

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. TrEMBL
Match: K7G5X0 (SCO cytochrome c oxidase assembly protein 1 OS=Pelodiscus sinensis OX=13735 GN=SCO1 PE=4 SV=1)

HSP 1 Score: 209.149 bits (531), Expect = 6.577e-63
Identity = 89/170 (52.35%), Postives = 126/170 (74.12%), Query Frame = 3

Query:  267 NSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYN 776
             + G P +GG F LVDH+G  RT  DF  +W+L+YFG+ HCPDICPE+LEKM L VD+ID   ++P++ P+F+++DP+RDT  ++A+Y+KEFS K++GLTG   +I+ + ++Y+V+Y +G KDE  DY+VDH IIMYLIGP GDF+ YYG  K   EI +SI + MR + 
Sbjct:   59 RALGKPLLGGPFSLVDHQGQPRTNKDFLGQWVLIYFGFTHCPDICPEELEKMILAVDEIDKIPSLPDVTPLFITIDPERDTGEAIARYVKEFSPKLVGLTGTKEQIEQVARAYRVYYSSGPKDEDNDYIVDHTIIMYLIGPDGDFVDYYGQNKKNSEIASSIAAHMRQHK 228

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. TrEMBL
Match: A0A091G1F6 (Uncharacterized protein (Fragment) OS=Cuculus canorus OX=55661 GN=N303_04651 PE=4 SV=1)

HSP 1 Score: 206.068 bits (523), Expect = 2.964e-62
Identity = 90/170 (52.94%), Postives = 124/170 (72.94%), Query Frame = 3

Query:  264 NNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNY 773
            N   G P +GG F LV+HKG  RT  D+  +W+L+YFG+ HCPDICP++LEKM  +VD+ID   ++PN+ P+F+++DP+RDT  ++A+Y+KEFS K+IGLTG   +I  + ++Y+V+Y  G KDE  DY+VDH IIMYL+GP GDF+ YYG  K   EI ASI + MR Y
Sbjct:   23 NRGIGKPLLGGPFSLVNHKGQPRTSKDYIGQWVLIYFGFTHCPDICPDELEKMIEVVDEIDRIPSLPNLTPLFITIDPERDTEEAIARYVKEFSPKLIGLTGTKAQIDQVAKAYRVYYSEGPKDEDDDYIVDHTIIMYLLGPDGDFVDYYGQNKRSTEISASIAAHMRKY 192

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. TrEMBL
Match: A0A091N4A5 (Uncharacterized protein (Fragment) OS=Acanthisitta chloris OX=57068 GN=N310_03492 PE=4 SV=1)

HSP 1 Score: 205.682 bits (522), Expect = 3.850e-62
Identity = 88/170 (51.76%), Postives = 123/170 (72.35%), Query Frame = 3

Query:  264 NNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNY 773
            N   G P +GG F LV H+G  RT  D+  +W+L+YFG+ HCPDICP++LEKM  +VD+ID   ++PN+ P+F+++DP+RD+  ++A+Y+KEFS K++GLTG   +I  + ++Y+V+Y  G KDE  DY+VDH IIMYL+GP GDF+ YYG  K   EI ASI S MR Y
Sbjct:   15 NRGIGKPLLGGPFSLVSHEGQPRTSKDYLGQWVLIYFGFTHCPDICPDELEKMVAVVDEIDRIPSLPNLTPLFITIDPERDSQEAIARYVKEFSPKLVGLTGTRAQIDQVAKAYRVYYSEGPKDEDNDYIVDHTIIMYLLGPDGDFVDYYGQNKRSTEISASIASHMRKY 184

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Cavefish
Match: sco1 (SCO cytochrome c oxidase assembly protein 1 [Source:ZFIN;Acc:ZDB-GENE-140909-1])

HSP 1 Score: 200.675 bits (509), Expect = 5.309e-62
Identity = 94/217 (43.32%), Postives = 134/217 (61.75%), Query Frame = 3

Query:  129 PKSRRKLMIVIGCTGFSFFIYGLAQYKNRQAEESYKLIFDIIDSSNNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNV 779
            P + + L I     G   F+ G+  +K  + E        I      S G   +GG F LVDH        DF  +W+L+YFG+ HCPDICP++LEKM+ +V +ID+   +P++ P+ +++DPDRDTP ++AKY+KEFS K+IGLTG   +I+  +++Y+V++  G KDE  DY+VDH IIMYL+GP G F+ YYG  K   EI ASI S MR   +
Sbjct:  102 PVTWKSLAITFAIGGT--FLLGMKYFKKEKEEM-------IERERTRSVGKAALGGPFSLVDHNNKPTKSDDFLGQWVLIYFGFTHCPDICPDELEKMAEVVKEIDSIRTLPDLTPLLITIDPDRDTPEALAKYVKEFSPKLIGLTGTAAQIQEASRAYRVYFSQGPKDEDNDYIVDHTIIMYLVGPDGQFVDYYGQNKKATEISASIASHMRKQKL 309

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Cavefish
Match: sco2 (SCO cytochrome c oxidase assembly protein 2 [Source:NCBI gene;Acc:606683])

HSP 1 Score: 194.126 bits (492), Expect = 7.559e-60
Identity = 81/160 (50.62%), Postives = 119/160 (74.38%), Query Frame = 3

Query:  294 GDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNY 773
            GDF L DH G +R++ D++  W+L+YFG+ HCPDICPE+LEKM+ +V+ +D  +N+P + P+FV+VDP+RD   ++AKY+K+F  ++IGLTG P E+K + Q+Y+V+   G KD+ GDY+VDH II+YLI P G FL YY  AKS  +I  S+ + M+N+
Sbjct:  114 GDFSLTDHTGKRRSKKDYRGSWVLMYFGFTHCPDICPEELEKMASVVNLLDEETNLPRVQPLFVTVDPERDDTATMAKYVKDFHPRLIGLTGTPEEVKEVGQTYRVYASAGPKDDDGDYIVDHTIIIYLINPDGLFLDYYNRAKSATQIAESVRNHMKNH 273

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Sea Lamprey
Match: sco2 (SCO cytochrome c oxidase assembly protein 2 [Source:NCBI gene;Acc:606683])

HSP 1 Score: 143.28 bits (360), Expect = 8.527e-42
Identity = 62/165 (37.58%), Postives = 107/165 (64.85%), Query Frame = 3

Query:  291 GGDFQLVDHKGVQRTRVDF-KNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEY-GDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNV 779
            G  F+L D  G +    D    +W L+YFG+ HCPD+CPE++EK+S ++  +D ++N+P + P+FV++DP RD   +VA+YIK+F  +++GLTG P +I  I+++Y+V+ + G +D    +Y+VDH+II YLI P G  L++Y  +    ++   +   +R + +
Sbjct:   39 GVKFELTDQSGRKVKGHDLLVGRWSLLYFGFTHCPDVCPEEMEKVSGVIHTLDKDTNLPRVQPVFVTIDPQRDDVAAVAQYIKDFHPRLVGLTGSPEQISAISKAYRVYAQPGPRDPTDQEYVVDHSIITYLICPHGAVLEFYNRSVEEADMAEKVRQRLRAHRL 203

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Yeast
Match: SCO2 (Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication [Source:SGD;Acc:S000000228])

HSP 1 Score: 132.109 bits (331), Expect = 1.190e-36
Identity = 62/154 (40.26%), Postives = 100/154 (64.94%), Query Frame = 3

Query:  261 SNNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKT--GIKDEYGDYLVDHAIIMYLIGPQGDFLQYYG 716
            +N +YG   +GG F L D  G   T  + K K+ ++YFG+ HCPDICPE+L++++  + ++D+  ++  I P+F+S DP RDTP+ + +Y+ +F   +IGLTG   ++K++ + YKV++ T   +K    DYLVDH+I  YLI P+G F+   G
Sbjct:  112 ANRAYGSVALGGPFNLTDFNGKPFTEENLKGKFSILYFGFSHCPDICPEELDRLTYWISELDDKDHI-KIQPLFISCDPARDTPDVLKEYLSDFHPAIIGLTGTYDQVKSVCKKYKVYFSTPRDVKPN-QDYLVDHSIFFYLIDPEGQFIDALG 263

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Yeast
Match: SCO1 (Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication [Source:SGD;Acc:S000000241])

HSP 1 Score: 125.946 bits (315), Expect = 2.445e-34
Identity = 60/172 (34.88%), Postives = 102/172 (59.30%), Query Frame = 3

Query:  261 SNNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYG-DYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNY 773
            +N  YG P +GG F L D  G + T  +   K+ ++YFG+ +CPDICP++L+K+ L ++ + +   +  + P+F++ DP RD+P  + +Y+ +F   ++GLTG   E+KN  + Y+V++ T    + G DYLVDH+I  YL+ P+G F+   G           IV  +++Y
Sbjct:  106 ANRGYGKPSLGGPFHLEDMYGNEFTEKNLLGKFSIIYFGFSNCPDICPDELDKLGLWLNTLSSKYGI-TLQPLFITCDPARDSPAVLKEYLSDFHPSILGLTGTFDEVKNACKKYRVYFSTPPNVKPGQDYLVDHSIFFYLMDPEGQFVDALGRNYDEKTGVDKIVEHVKSY 276

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Nematostella
Match: EDO49876 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7REY8])

HSP 1 Score: 180.259 bits (456), Expect = 1.062e-55
Identity = 78/171 (45.61%), Postives = 115/171 (67.25%), Query Frame = 3

Query:  267 NSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNV 779
             S G   +GG F L+DH G  +T  DF+ KWLL+YFG+ HCPDICP++LEKM+  +D          + P+F+SVDP RDT  +VA+Y+KEF  K++GLTG   +++ + ++Y+V++  G  DE  DY+VDH II YL+ P G+F++Y+G  K+ +EI ASI + M  Y +
Sbjct:   39 RSIGKVALGGPFDLIDHHGKPKTDKDFRGKWLLLYFGFTHCPDICPDELEKMAEAIDLTTKGKVSEELQPLFISVDPKRDTVEAVAEYVKEFHPKLLGLTGPVEKVQEVCKAYRVYFSAGPADEDNDYIVDHTIIQYLVSPDGEFMEYFGQNKNAEEIAASITNHMLKYKL 209

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Nematostella
Match: EDO25395 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8DWL6])

HSP 1 Score: 54.299 bits (129), Expect = 1.137e-9
Identity = 31/97 (31.96%), Postives = 48/97 (49.48%), Query Frame = 3

Query:  477 IFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFY----KTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIV 755
            IFVSVDP+RDT   +A+YI  F    +G+TG+  ++  +  +    Y         DE  +YLVDH   + L+ P G F   + S  +   I   ++
Sbjct:    4 IFVSVDPERDTLEKLAQYIPYFHPTFLGVTGEHDQLTQLAHNLGAMYLKLPAAAENDE--NYLVDHTGSILLVNPAGHFHAVFTSPHNAQAIAKDLI 98

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Medaka
Match: sco1 (protein SCO1 homolog, mitochondrial [Source:NCBI gene;Acc:101175404])

HSP 1 Score: 197.978 bits (502), Expect = 3.255e-61
Identity = 85/171 (49.71%), Postives = 122/171 (71.35%), Query Frame = 3

Query:  264 NNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYN 776
            N S G P +GG F LVDH        DF  +W+L+YFG+ HCPDICP+++EKM  +VD+ID   ++PN+ P+ +++DP+RDTP ++A Y+KEFS K+IGLTG   +I+ ++++Y+V+Y  G KDE  DY+VDH IIMYLIGP G+F++Y+G  K   EI  SI + MR + 
Sbjct:  109 NKSIGRPALGGPFSLVDHNNKPTKSQDFLGQWVLLYFGFTHCPDICPDEIEKMIEVVDEIDKIQSLPNLTPLLITIDPERDTPEAMAAYVKEFSPKLIGLTGSTAQIEEVSRAYRVYYSQGPKDEDNDYIVDHTIIMYLIGPDGEFVEYFGQNKRGVEISNSIAAHMRKHR 279

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Medaka
Match: sco2 (SCO cytochrome c oxidase assembly protein 2 [Source:NCBI gene;Acc:606683])

HSP 1 Score: 181.415 bits (459), Expect = 4.032e-55
Identity = 76/163 (46.63%), Postives = 118/163 (72.39%), Query Frame = 3

Query:  294 GDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNVL 782
            G F LVDH G +RT+ DF   W+L+YFG+ HCPDICP++L+K+S  V  +D ++++P + P+F++VDP+RD   ++A+Y+K+F  ++IGLTG P E+K+  + Y+V+   G KD+ GDY+VDH+I++YL+ P G FL YY   KS ++I  S+ + MR+Y  L
Sbjct:   93 GTFSLVDHTGRRRTKQDFLGSWVLLYFGFTHCPDICPDELDKLSAAVAVLDQDASLPPVQPLFITVDPERDGVPALARYVKDFHPRLIGLTGTPEEVKHAGRDYRVYASPGPKDQDGDYIVDHSILIYLLSPDGLFLDYYNRMKSSEQIADSVRNHMRSYQRL 255

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Planmine SMEST
Match: SMESG000073891.1 (SMESG000073891.1)

HSP 1 Score: 434.106 bits (1115), Expect = 2.780e-155
Identity = 211/212 (99.53%), Postives = 211/212 (99.53%), Query Frame = 3

Query:  150 MIVIGCTGFSFFIYGLAQYKNRQAEESYKLIFDIIDSSNNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNVLV 785
            MIVIGCTGFSFFIYGLAQYKNRQAEESYKLIFDIIDSSNNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYK GIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNVLV
Sbjct:    1 MIVIGCTGFSFFIYGLAQYKNRQAEESYKLIFDIIDSSNNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKAGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNVLV 212

[Close]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Planmine SMEST
Match: SMESG000067103.1 (SMESG000067103.1)

HSP 1 Score: 208.379 bits (529), Expect = 4.097e-66
Identity = 102/234 (43.59%), Postives = 151/234 (64.53%), Query Frame = 3

Query:   63 KFLRFSKILNINQSFYCSKSLLPKSRRKLMIVIGCTGFSFFIYGLAQYKNRQAEESYKLIFDIIDSSNNSYGDPDIGGDFQLVDHKGVQRTRVDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVSVDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDEYGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEM 764
            KF R    +   + F  S         K+ +       S FI G   YK  + +E  KLI  + +  N   G P IGGDF LVDH G   + +DF++KWLL+YFG+C+CPD+CP+Q+EK+ ++VD++ +     N++P+FVSVDP+RDTP  +  Y+KEFS K++GLTG   +I  ++++Y+++Y  G  D++GDY+VDHAIIMYLIGP+G+F++YYG  +S+ EI  SI   M
Sbjct:    3 KFSRLFNSVKFGRRFCSSNPKQDSKYSKMALKTSIFAGSIFIAGYF-YKKYRIDEFEKLI--VQNKLNEGVGTPLIGGDFHLVDHNGTSVSLLDFRSKWLLIYFGFCNCPDVCPDQIEKVVMVVDRLAHKK--INVVPLFVSVDPERDTPEIMKDYLKEFSNKILGLTGSVEDIHAVSKTYRIYYSKGPVDKFGDYIVDHAIIMYLIGPEGEFVEYYGQNRSVPEIARSIQGHM 231

The following BLAST results are available for this feature:

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Human
BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Celegans
BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Fly
BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Zebrafish
BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Xenopus
BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Mouse
BLAST of SCO cytochrome c oxidase assembly protein 1 vs. UniProt/SwissProt
BLAST of SCO cytochrome c oxidase assembly protein 1 vs. TrEMBL
BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Cavefish
BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Sea Lamprey
BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Yeast
BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Nematostella
BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Medaka
BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Planmine SMEST

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
SCO1	1.727e-62	51.50	SCO cytochrome c oxidase assembly protein 1 [Sourc...	[more]
SCO2	5.226e-52	40.85	SCO cytochrome c oxidase assembly protein 2 [Sourc...	[more]
SCO2	5.226e-52	40.85	SCO cytochrome c oxidase assembly protein 2 [Sourc...	[more]
SCO2	5.226e-52	40.85	SCO cytochrome c oxidase assembly protein 2 [Sourc...	[more]
SCO2	5.226e-52	40.85	SCO cytochrome c oxidase assembly protein 2 [Sourc...	[more]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
sco-1	5.541e-41	36.63	SCO (Yeast Suppressor of Cytochrome Oxidase defici...	[more]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Scox	3.883e-61	39.56	gene:FBgn0262467 transcript:FBtr0079052	[more]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
sco1	1.669e-58	47.40	SCO cytochrome c oxidase assembly protein 1 [Sourc...	[more]
sco1	1.838e-58	47.40	SCO cytochrome c oxidase assembly protein 1 [Sourc...	[more]
sco2	6.757e-52	43.75	SCO cytochrome c oxidase assembly protein 2 [Sourc...	[more]
sco2	6.757e-52	43.75	SCO cytochrome c oxidase assembly protein 2 [Sourc...	[more]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2


Match Name	E-value	Identity	Description
sirt4	1.799e-63	43.26	sirtuin 4 [Source:Xenbase;Acc:XB-GENE-948981]	[more]
sec24a	6.848e-53	44.72	SEC24 homolog A, COPII coat complex component [Sou...	[more]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Sco1	9.810e-63	42.79	SCO1 cytochrome c oxidase assembly protein [Source...	[more]
Sco1	1.225e-61	50.00	SCO1 cytochrome c oxidase assembly protein [Source...	[more]
Sco2	2.634e-53	33.86	SCO2 cytochrome c oxidase assembly protein [Source...	[more]
Sco2	2.634e-53	33.86	SCO2 cytochrome c oxidase assembly protein [Source...	[more]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|O75880\|SCO1_HUMAN	8.293e-62	51.50	Protein SCO1 homolog, mitochondrial OS=Homo sapien...	[more]
sp\|Q5SUC9\|SCO1_MOUSE	8.566e-61	50.00	Protein SCO1 homolog, mitochondrial OS=Mus musculu...	[more]
sp\|A1A4J8\|SCO1_BOVIN	1.106e-60	50.29	Protein SCO1 homolog, mitochondrial OS=Bos taurus ...	[more]
sp\|A6H784\|SCO2_BOVIN	1.738e-52	42.07	Protein SCO2 homolog, mitochondrial OS=Bos taurus ...	[more]
sp\|Q8VCL2\|SCO2_MOUSE	1.842e-52	33.86	Protein SCO2 homolog, mitochondrial OS=Mus musculu...	[more]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A452IUW6	9.870e-64	54.12	SCO cytochrome c oxidase assembly protein 1 OS=Gop...	[more]
A0A4D9DQT7	1.353e-63	54.12	EMILIN-1 OS=Platysternon megacephalum OX=55544 GN=...	[more]
K7G5X0	6.577e-63	52.35	SCO cytochrome c oxidase assembly protein 1 OS=Pel...	[more]
A0A091G1F6	2.964e-62	52.94	Uncharacterized protein (Fragment) OS=Cuculus cano...	[more]
A0A091N4A5	3.850e-62	51.76	Uncharacterized protein (Fragment) OS=Acanthisitta...	[more]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
sco1	5.309e-62	43.32	SCO cytochrome c oxidase assembly protein 1 [Sourc...	[more]
sco2	7.559e-60	50.63	SCO cytochrome c oxidase assembly protein 2 [Sourc...	[more]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
sco2	8.527e-42	37.58	SCO cytochrome c oxidase assembly protein 2 [Sourc...	[more]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2


Match Name	E-value	Identity	Description
SCO2	1.190e-36	40.26	Protein anchored to mitochondrial inner membrane; ...	[more]
SCO1	2.445e-34	34.88	Copper-binding protein of mitochondrial inner memb...	[more]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO49876	1.062e-55	45.61	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO25395	1.137e-9	31.96	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8...	[more]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
sco1	3.255e-61	49.71	protein SCO1 homolog, mitochondrial [Source:NCBI g...	[more]
sco2	4.032e-55	46.63	SCO cytochrome c oxidase assembly protein 2 [Sourc...	[more]

BLAST of SCO cytochrome c oxidase assembly protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2


Match Name	E-value	Identity	Description
SMESG000073891.1	2.780e-155	99.53	SMESG000073891.1	[more]
SMESG000067103.1	4.097e-66	43.59	SMESG000067103.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30023957 ID=SMED30023957|Name=SCO cytochrome c oxidase assembly protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1009bp
CAATACTTTGTTTAAATAATTATTAATTTAAAATTAAAATGAACAATTTC
TCGAAGTACATAAAATTTTTAAGGTTTTCTAAAATTTTAAACATCAATCA
ATCATTTTATTGCAGTAAATCTTTGTTACCAAAATCCAGAAGAAAATTGA
TGATAGTAATAGGATGTACTGGATTCAGTTTTTTTATATATGGTTTAGCT
CAATATAAAAATAGGCAGGCTGAAGAGTCTTATAAACTTATTTTTGATAT
TATTGATTCATCTAATAATTCATATGGGGATCCTGATATAGGAGGAGATT
TTCAACTAGTTGATCATAAAGGAGTTCAGAGGACCAGAGTAGATTTTAAA
AATAAATGGTTATTAGTATATTTTGGTTATTGTCATTGCCCCGATATCTG
CCCTGAGCAGTTAGAAAAAATGTCACTTATCGTAGATAAAATCGACAATA
ATTCCAATGTGCCAAATATCATACCGATATTCGTCAGTGTTGACCCTGAC
AGAGATACTCCTAATAGTGTAGCTAAATATATAAAGGAATTCTCTACCAA
AATGATTGGATTAACCGGAGATCCTCATGAAATCAAAAATATTACGCAGT
CATATAAAGTATTTTATAAAACTGGAATAAAAGATGAATATGGCGATTAC
TTGGTCGATCATGCAATAATCATGTATCTCATCGGTCCTCAAGGTGATTT
CCTCCAATATTATGGCTCTGCGAAATCTATCGATGAAATATATGCTTCTA
TCGTATCAGAAATGAGAAATTATAATGTGTTGGTTTAATGTTGTAAAGGG
CAGTCATTTTTAGTACAATTTTTGTAACCATCGTGATAGTTTTGTTTTAT
TCATTTTCTTGTAATAATTTTTTATAGATTTTTATTGACAATTTTGTAAT
CGCACTGTCCTCAACTTTGGTTACATACTACAGTAGTGAATTGTGTGCCA
TCTGACACTTTGGCACCTAAATGCTTCCTACTAAATAATATTTCAGATTA
TAAATAAAG

protein sequence of SMED30023957-orf-1

>SMED30023957-orf-1 ID=SMED30023957-orf-1|Name=SMED30023957-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=250bp
MNNFSKYIKFLRFSKILNINQSFYCSKSLLPKSRRKLMIVIGCTGFSFFI
YGLAQYKNRQAEESYKLIFDIIDSSNNSYGDPDIGGDFQLVDHKGVQRTR
VDFKNKWLLVYFGYCHCPDICPEQLEKMSLIVDKIDNNSNVPNIIPIFVS
VDPDRDTPNSVAKYIKEFSTKMIGLTGDPHEIKNITQSYKVFYKTGIKDE
YGDYLVDHAIIMYLIGPQGDFLQYYGSAKSIDEIYASIVSEMRNYNVLV*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000499	cell
PLANA:0002109	X1 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036249	Thioredoxin-like_sf
IPR012336	Thioredoxin-like_fold
IPR003782	SCO1/SenC

Vocabulary: **molecular function**
Term	Definition
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Vocabulary: **cellular component**
Term	Definition
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0030016	myofibril
GO:0072492	host cell mitochondrial intermembrane space

Vocabulary: **biological process**
Term	Definition
GO:0006091	generation of precursor metabolites and energy
GO:0006825	copper ion transport
GO:0006878	cellular copper ion homeostasis
GO:0008535	respiratory chain complex IV assembly
GO:0033617	mitochondrial respiratory chain complex IV assembly
GO:1901799	negative regulation of proteasomal protein catabolic process

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR036249	Thioredoxin-like superfamily	GENE3D	G3DSA:3.40.30.10		coord: 81..249 e-value: 1.2E-53 score: 183.2
IPR036249	Thioredoxin-like superfamily	SUPERFAMILY	SSF52833	Thioredoxin-like	coord: 82..242
IPR003782	Copper chaperone SCO1/SenC	PFAM	PF02630	SCO1-SenC	coord: 85..221 e-value: 7.3E-44 score: 148.9
IPR003782	Copper chaperone SCO1/SenC	PANTHER	PTHR12151	SCO1/SENC	coord: 37..246
IPR003782	Copper chaperone SCO1/SenC	CDD	cd02968	SCO	coord: 84..226 e-value: 5.78752E-55 score: 171.247
None	No IPR available	PANTHER	PTHR12151:SF5	AT19154P	coord: 37..246
None	No IPR available	TMHMM	TMhelix		coord: 37..56