Mitogen-activated protein kinase kinase kinase kinase 4

Overview
NameMitogen-activated protein kinase kinase kinase kinase 4
Smed IDSMED30023902
Length (bp)4675
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Mitogen-activated protein kinase kinase kinase kinase 4 (SMED30023902) t-SNE clustered cells

Violin plots show distribution of expression levels for Mitogen-activated protein kinase kinase kinase kinase 4 (SMED30023902) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Mitogen-activated protein kinase kinase kinase kinase 4 (SMED30023902) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Mitogen-activated protein kinase kinase kinase kinase 4 (SMED30023902) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30023902

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30023902SMESG000031711.1 dd_Smed_v4_1029_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30023902SMESG000031711.1 dd_Smed_v4_1029_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Human
Match: MINK1 (misshapen like kinase 1 [Source:HGNC Symbol;Acc:HGNC:17565])

HSP 1 Score: 393.66 bits (1010), Expect = 2.300e-121
Identity = 184/261 (70.50%), Postives = 222/261 (85.06%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNF 979
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T+ E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDLV++T+ N+LKED IAYI REIL+GL++LHA+ VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD RSD+WSL IT+IEMAEG PPLC++HPMRALFLI RNPPP+LKS+KWS  F DF++  LIK +
Sbjct:    9 DLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTY 269
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Human
Match: TNIK (TRAF2 and NCK interacting kinase [Source:HGNC Symbol;Acc:HGNC:30765])

HSP 1 Score: 400.979 bits (1029), Expect = 1.018e-116
Identity = 183/268 (68.28%), Postives = 222/268 (82.84%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T  E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDL+++T+ N+LKE+WIAYI REIL+GLS+LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD +SDLWSL IT+IEMAEG PPLC++HPMRALFLI RNP P+LKS+KWS  F  F+E  L+KN  +   T+
Sbjct:   14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATE 281

HSP 2 Score: 318.931 bits (816), Expect = 8.381e-89
Identity = 149/311 (47.91%), Postives = 214/311 (68.81%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KK+F  EI  A  WG N LVG+E+GL  +DR+ Q KV  L+N+R+F Q+DVLE + ++++ISGK+++LR+Y L WL+N+I+ +D + E K GW  +G DLE    +K V +E I FLVI+LKN +++YAWAP+P  KFM +K   +L  KPLL++L++ +     V++ +  GF+ ID+ S   Y++YIP H+   I PH IV +P +DGM +L+CY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VRS  S  +  + L
Sbjct:  951 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVG-DLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1260
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Human
Match: TNIK (TRAF2 and NCK interacting kinase [Source:HGNC Symbol;Acc:HGNC:30765])

HSP 1 Score: 400.593 bits (1028), Expect = 1.325e-116
Identity = 183/268 (68.28%), Postives = 222/268 (82.84%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T  E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDL+++T+ N+LKE+WIAYI REIL+GLS+LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD +SDLWSL IT+IEMAEG PPLC++HPMRALFLI RNP P+LKS+KWS  F  F+E  L+KN  +   T+
Sbjct:   14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATE 281

HSP 2 Score: 318.931 bits (816), Expect = 9.654e-89
Identity = 149/311 (47.91%), Postives = 214/311 (68.81%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KK+F  EI  A  WG N LVG+E+GL  +DR+ Q KV  L+N+R+F Q+DVLE + ++++ISGK+++LR+Y L WL+N+I+ +D + E K GW  +G DLE    +K V +E I FLVI+LKN +++YAWAP+P  KFM +K   +L  KPLL++L++ +     V++ +  GF+ ID+ S   Y++YIP H+   I PH IV +P +DGM +L+CY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VRS  S  +  + L
Sbjct:  959 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVG-DLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1268
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Human
Match: TNIK (TRAF2 and NCK interacting kinase [Source:HGNC Symbol;Acc:HGNC:30765])

HSP 1 Score: 400.979 bits (1029), Expect = 1.616e-116
Identity = 183/268 (68.28%), Postives = 222/268 (82.84%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T  E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDL+++T+ N+LKE+WIAYI REIL+GLS+LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD +SDLWSL IT+IEMAEG PPLC++HPMRALFLI RNP P+LKS+KWS  F  F+E  L+KN  +   T+
Sbjct:   14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATE 281

HSP 2 Score: 319.316 bits (817), Expect = 9.013e-89
Identity = 149/311 (47.91%), Postives = 214/311 (68.81%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KK+F  EI  A  WG N LVG+E+GL  +DR+ Q KV  L+N+R+F Q+DVLE + ++++ISGK+++LR+Y L WL+N+I+ +D + E K GW  +G DLE    +K V +E I FLVI+LKN +++YAWAP+P  KFM +K   +L  KPLL++L++ +     V++ +  GF+ ID+ S   Y++YIP H+   I PH IV +P +DGM +L+CY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VRS  S  +  + L
Sbjct:  988 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVG-DLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1297
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Human
Match: TNIK (TRAF2 and NCK interacting kinase [Source:HGNC Symbol;Acc:HGNC:30765])

HSP 1 Score: 400.593 bits (1028), Expect = 2.168e-116
Identity = 183/268 (68.28%), Postives = 222/268 (82.84%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T  E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDL+++T+ N+LKE+WIAYI REIL+GLS+LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD +SDLWSL IT+IEMAEG PPLC++HPMRALFLI RNP P+LKS+KWS  F  F+E  L+KN  +   T+
Sbjct:   14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATE 281

HSP 2 Score: 319.316 bits (817), Expect = 8.307e-89
Identity = 149/311 (47.91%), Postives = 214/311 (68.81%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KK+F  EI  A  WG N LVG+E+GL  +DR+ Q KV  L+N+R+F Q+DVLE + ++++ISGK+++LR+Y L WL+N+I+ +D + E K GW  +G DLE    +K V +E I FLVI+LKN +++YAWAP+P  KFM +K   +L  KPLL++L++ +     V++ +  GF+ ID+ S   Y++YIP H+   I PH IV +P +DGM +L+CY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VRS  S  +  + L
Sbjct:  980 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVG-DLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1289
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Celegans
Match: mig-15 (Serine/threonine-protein kinase mig-15 [Source:UniProtKB/Swiss-Prot;Acc:Q23356])

HSP 1 Score: 390.193 bits (1001), Expect = 6.169e-115
Identity = 181/266 (68.05%), Postives = 222/266 (83.46%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA----DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLK-SRKWSTNFHDFLEKALIKNFHE 985
            +L SL+DPAGIF LIE+VG GTYG VYKG+ +KT  LAAIK+M I + E++EI LEIN L++ S H NVA YYGAF+K   ++    D LWLVMEFCG+GSITDLV++T+  SLKE+WIAYI REIL+GL +LH + VIHRDIKGQNVLL D+AEVKLVDFGVSAQLD+T G+RNTFIGTPYWMAPEVI C+E+P +TYD+RSDLWSL IT++EMAEG PPLC++HPMRALFLI RNPPPKLK ++KW+  F  F+E  L+K++H+
Sbjct:   10 DLNSLRDPAGIFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNINEDEEDEIKLEINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRNPPPKLKRNKKWTKKFETFIETVLVKDYHQ 275

HSP 2 Score: 303.523 bits (776), Expect = 3.772e-85
Identity = 149/327 (45.57%), Postives = 214/327 (65.44%), Query Frame = 2 
Query: 3296 AGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSD------TQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            A N   ++   KKKF+ EI  A  WG N L+G++SGL  +DR+ Q KV  L+++R+F Q+ VLE   I+ +ISG++ R+R+Y L WL+ KI++++      T E + GW N+G DL+    FK V +E I FLV+ L++ I++YAWAP+P  KFM +K   +L   PL+++L++   +   VLY +T GF+AIDL S   Y++Y P        PHCIV +PNS+GM LLLCY+ EGVYV+  G + K+VVLQWGE+P+SV + S  QI+ WG KAIEIR V+ G + G+F HK+  K KFL E+N+KV FS+ +   S  I  + L
Sbjct:  739 AENDAPEIRKYKKKFSGEILCAALWGVNLLIGTDSGLMLLDRSGQGKVYPLISRRRFDQMTVLEGQNILATISGRKRRIRVYYLSWLRQKILRTEGAGSANTTEKRNGWVNVG-DLQGAIHFKIVRYERIKFLVVGLESSIEIYAWAPKPYHKFMSFKSFGSLSHVPLIVDLTVEDNARLKVLYGSTGGFHAIDLDSAAVYDIYTPAQSGQTTTPHCIVVLPNSNGMQLLLCYDNEGVYVNTYGRMTKNVVLQWGEMPSSVAYISTGQIMGWGNKAIEIRSVDTGHLDGVFMHKKAQKLKFLCERNDKVFFSSAKGGGSCQIYFMTL 1064
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Celegans
Match: mig-15 (Serine/threonine-protein kinase mig-15 [Source:UniProtKB/Swiss-Prot;Acc:Q23356])

HSP 1 Score: 390.578 bits (1002), Expect = 6.792e-115
Identity = 181/266 (68.05%), Postives = 222/266 (83.46%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA----DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLK-SRKWSTNFHDFLEKALIKNFHE 985
            +L SL+DPAGIF LIE+VG GTYG VYKG+ +KT  LAAIK+M I + E++EI LEIN L++ S H NVA YYGAF+K   ++    D LWLVMEFCG+GSITDLV++T+  SLKE+WIAYI REIL+GL +LH + VIHRDIKGQNVLL D+AEVKLVDFGVSAQLD+T G+RNTFIGTPYWMAPEVI C+E+P +TYD+RSDLWSL IT++EMAEG PPLC++HPMRALFLI RNPPPKLK ++KW+  F  F+E  L+K++H+
Sbjct:   10 DLNSLRDPAGIFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNINEDEEDEIKLEINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRNPPPKLKRNKKWTKKFETFIETVLVKDYHQ 275

HSP 2 Score: 303.908 bits (777), Expect = 3.642e-85
Identity = 149/327 (45.57%), Postives = 214/327 (65.44%), Query Frame = 2 
Query: 3296 AGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSD------TQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            A N   ++   KKKF+ EI  A  WG N L+G++SGL  +DR+ Q KV  L+++R+F Q+ VLE   I+ +ISG++ R+R+Y L WL+ KI++++      T E + GW N+G DL+    FK V +E I FLV+ L++ I++YAWAP+P  KFM +K   +L   PL+++L++   +   VLY +T GF+AIDL S   Y++Y P        PHCIV +PNS+GM LLLCY+ EGVYV+  G + K+VVLQWGE+P+SV + S  QI+ WG KAIEIR V+ G + G+F HK+  K KFL E+N+KV FS+ +   S  I  + L
Sbjct:  749 AENDAPEIRKYKKKFSGEILCAALWGVNLLIGTDSGLMLLDRSGQGKVYPLISRRRFDQMTVLEGQNILATISGRKRRIRVYYLSWLRQKILRTEGAGSANTTEKRNGWVNVG-DLQGAIHFKIVRYERIKFLVVGLESSIEIYAWAPKPYHKFMSFKSFGSLSHVPLIVDLTVEDNARLKVLYGSTGGFHAIDLDSAAVYDIYTPAQSGQTTTPHCIVVLPNSNGMQLLLCYDNEGVYVNTYGRMTKNVVLQWGEMPSSVAYISTGQIMGWGNKAIEIRSVDTGHLDGVFMHKKAQKLKFLCERNDKVFFSSAKGGGSCQIYFMTL 1074
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Celegans
Match: mig-15 (Serine/threonine-protein kinase mig-15 [Source:UniProtKB/Swiss-Prot;Acc:Q23356])

HSP 1 Score: 390.193 bits (1001), Expect = 8.010e-115
Identity = 181/266 (68.05%), Postives = 222/266 (83.46%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA----DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLK-SRKWSTNFHDFLEKALIKNFHE 985
            +L SL+DPAGIF LIE+VG GTYG VYKG+ +KT  LAAIK+M I + E++EI LEIN L++ S H NVA YYGAF+K   ++    D LWLVMEFCG+GSITDLV++T+  SLKE+WIAYI REIL+GL +LH + VIHRDIKGQNVLL D+AEVKLVDFGVSAQLD+T G+RNTFIGTPYWMAPEVI C+E+P +TYD+RSDLWSL IT++EMAEG PPLC++HPMRALFLI RNPPPKLK ++KW+  F  F+E  L+K++H+
Sbjct:   10 DLNSLRDPAGIFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNINEDEEDEIKLEINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRNPPPKLKRNKKWTKKFETFIETVLVKDYHQ 275

HSP 2 Score: 303.908 bits (777), Expect = 4.183e-85
Identity = 149/327 (45.57%), Postives = 214/327 (65.44%), Query Frame = 2 
Query: 3296 AGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSD------TQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            A N   ++   KKKF+ EI  A  WG N L+G++SGL  +DR+ Q KV  L+++R+F Q+ VLE   I+ +ISG++ R+R+Y L WL+ KI++++      T E + GW N+G DL+    FK V +E I FLV+ L++ I++YAWAP+P  KFM +K   +L   PL+++L++   +   VLY +T GF+AIDL S   Y++Y P        PHCIV +PNS+GM LLLCY+ EGVYV+  G + K+VVLQWGE+P+SV + S  QI+ WG KAIEIR V+ G + G+F HK+  K KFL E+N+KV FS+ +   S  I  + L
Sbjct:  754 AENDAPEIRKYKKKFSGEILCAALWGVNLLIGTDSGLMLLDRSGQGKVYPLISRRRFDQMTVLEGQNILATISGRKRRIRVYYLSWLRQKILRTEGAGSANTTEKRNGWVNVG-DLQGAIHFKIVRYERIKFLVVGLESSIEIYAWAPKPYHKFMSFKSFGSLSHVPLIVDLTVEDNARLKVLYGSTGGFHAIDLDSAAVYDIYTPAQSGQTTTPHCIVVLPNSNGMQLLLCYDNEGVYVNTYGRMTKNVVLQWGEMPSSVAYISTGQIMGWGNKAIEIRSVDTGHLDGVFMHKKAQKLKFLCERNDKVFFSSAKGGGSCQIYFMTL 1079
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Celegans
Match: mig-15 (Serine/threonine-protein kinase mig-15 [Source:UniProtKB/Swiss-Prot;Acc:Q23356])

HSP 1 Score: 390.193 bits (1001), Expect = 9.606e-115
Identity = 181/266 (68.05%), Postives = 222/266 (83.46%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA----DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLK-SRKWSTNFHDFLEKALIKNFHE 985
            +L SL+DPAGIF LIE+VG GTYG VYKG+ +KT  LAAIK+M I + E++EI LEIN L++ S H NVA YYGAF+K   ++    D LWLVMEFCG+GSITDLV++T+  SLKE+WIAYI REIL+GL +LH + VIHRDIKGQNVLL D+AEVKLVDFGVSAQLD+T G+RNTFIGTPYWMAPEVI C+E+P +TYD+RSDLWSL IT++EMAEG PPLC++HPMRALFLI RNPPPKLK ++KW+  F  F+E  L+K++H+
Sbjct:   10 DLNSLRDPAGIFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNINEDEEDEIKLEINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRNPPPKLKRNKKWTKKFETFIETVLVKDYHQ 275

HSP 2 Score: 303.523 bits (776), Expect = 5.907e-85
Identity = 149/327 (45.57%), Postives = 214/327 (65.44%), Query Frame = 2 
Query: 3296 AGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSD------TQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            A N   ++   KKKF+ EI  A  WG N L+G++SGL  +DR+ Q KV  L+++R+F Q+ VLE   I+ +ISG++ R+R+Y L WL+ KI++++      T E + GW N+G DL+    FK V +E I FLV+ L++ I++YAWAP+P  KFM +K   +L   PL+++L++   +   VLY +T GF+AIDL S   Y++Y P        PHCIV +PNS+GM LLLCY+ EGVYV+  G + K+VVLQWGE+P+SV + S  QI+ WG KAIEIR V+ G + G+F HK+  K KFL E+N+KV FS+ +   S  I  + L
Sbjct:  763 AENDAPEIRKYKKKFSGEILCAALWGVNLLIGTDSGLMLLDRSGQGKVYPLISRRRFDQMTVLEGQNILATISGRKRRIRVYYLSWLRQKILRTEGAGSANTTEKRNGWVNVG-DLQGAIHFKIVRYERIKFLVVGLESSIEIYAWAPKPYHKFMSFKSFGSLSHVPLIVDLTVEDNARLKVLYGSTGGFHAIDLDSAAVYDIYTPAQSGQTTTPHCIVVLPNSNGMQLLLCYDNEGVYVNTYGRMTKNVVLQWGEMPSSVAYISTGQIMGWGNKAIEIRSVDTGHLDGVFMHKKAQKLKFLCERNDKVFFSSAKGGGSCQIYFMTL 1088
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Celegans
Match: cst-2 (Caenorhabditis STE20-like kinase [Source:UniProtKB/TrEMBL;Acc:Q304D8])

HSP 1 Score: 233.032 bits (593), Expect = 7.178e-67
Identity = 123/261 (47.13%), Postives = 169/261 (64.75%), Query Frame = 2 
Query:  218 KDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKS-RKWSTNFHDFLEKALIKNFHEVITT 997
            K P  +F ++  +G+G+YG+V+K    ++G + AIK + +   + +EII EI+ +++      V  YYG++ KH      LW+VME+CGAGSI+D++R+ R   L E  I+ + R+ L+GL YLH    IHRDIK  N+LLN +   KL DFGV+ QL  T  KRNT IGTP+WMAPEVI  EE     YD ++D+WSL IT+IEMAEGRPP  +IHPMRA+F+I   PPP  K   +WS+ F+DF+   LIK   E  T 
Sbjct:   29 KPPEEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDT-DLQEIIKEISIMQQCKSK-YVVKYYGSYFKHSD----LWIVMEYCGAGSISDIMRA-RRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI--EE---IGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTA 277
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Fly
Match: msn (gene:FBgn0010909 transcript:FBtr0072959)

HSP 1 Score: 405.216 bits (1040), Expect = 8.489e-120
Identity = 188/263 (71.48%), Postives = 225/263 (85.55%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHE 985
            +L +LKDPAGIF LIE+VG GTYG VYKG+  KTG LAAIKVM++T+ E+EEI LEIN L++ S+H N+A YYGAF+K       D LWLVME+CGAGS+TDLV+ST+  SLKE+WIAYI REIL+GLSYLH+N VIHRDIKGQNVLL DNAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD RSDLWSL IT++EMAE +PPLC++HPMRALFLI RN PP+LKS+KWS  FH F++  L+K++H+
Sbjct:   21 DLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDTVLVKDYHQ 283

HSP 2 Score: 322.783 bits (826), Expect = 2.471e-91
Identity = 155/331 (46.83%), Postives = 225/331 (67.98%), Query Frame = 2 
Query: 3278 VPLSALAGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMK----SDTQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
             P S  A N   ++   KK+F  EI  A  WG N L+G+E+GL  +DR+ Q KV +L+++R+F Q++VLE   I+++ISGK++R+R+Y L WLK+KI++    SD  E + GW N+G DL+    FK V +E I FLVI+LK+ I++YAWAP+P  KFM +K    L  +PLL++L+I  +S   V+Y + +GF+A+DL S   Y++Y+P+H    I PHCIV +PNS+GM LLLCY+ EGVYV+  G V K++VLQWGE+P SV +    QI+ WG KAIEIR V +G + G+F HK+  + KFL E+N+KV FS+ + ++S  I  + L
Sbjct:  765 TPTSHEAANDTPEIRKYKKRFNSEILCAALWGVNLLIGTENGLMLLDRSGQGKVYQLISRRRFQQMEVLEGQNILVTISGKKNRVRVYYLSWLKSKILRTDGLSDQVERRNGWINVG-DLQGAVHFKIVKYERIKFLVIALKDSIEIYAWAPKPYHKFMAFKNFGELEHRPLLVDLTIEDQSRLKVIYGSAEGFHAVDLDSAEVYDIYLPKHTQGAIIPHCIVALPNSNGMQLLLCYDNEGVYVNTVGRVSKNIVLQWGEMPTSVAYIGTGQIMGWGNKAIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKVFFSSAKGASSCQIYFMTL 1094
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Fly
Match: msn (gene:FBgn0010909 transcript:FBtr0072958)

HSP 1 Score: 405.216 bits (1040), Expect = 8.489e-120
Identity = 188/263 (71.48%), Postives = 225/263 (85.55%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHE 985
            +L +LKDPAGIF LIE+VG GTYG VYKG+  KTG LAAIKVM++T+ E+EEI LEIN L++ S+H N+A YYGAF+K       D LWLVME+CGAGS+TDLV+ST+  SLKE+WIAYI REIL+GLSYLH+N VIHRDIKGQNVLL DNAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD RSDLWSL IT++EMAE +PPLC++HPMRALFLI RN PP+LKS+KWS  FH F++  L+K++H+
Sbjct:   21 DLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDTVLVKDYHQ 283

HSP 2 Score: 322.783 bits (826), Expect = 2.471e-91
Identity = 155/331 (46.83%), Postives = 225/331 (67.98%), Query Frame = 2 
Query: 3278 VPLSALAGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMK----SDTQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
             P S  A N   ++   KK+F  EI  A  WG N L+G+E+GL  +DR+ Q KV +L+++R+F Q++VLE   I+++ISGK++R+R+Y L WLK+KI++    SD  E + GW N+G DL+    FK V +E I FLVI+LK+ I++YAWAP+P  KFM +K    L  +PLL++L+I  +S   V+Y + +GF+A+DL S   Y++Y+P+H    I PHCIV +PNS+GM LLLCY+ EGVYV+  G V K++VLQWGE+P SV +    QI+ WG KAIEIR V +G + G+F HK+  + KFL E+N+KV FS+ + ++S  I  + L
Sbjct:  765 TPTSHEAANDTPEIRKYKKRFNSEILCAALWGVNLLIGTENGLMLLDRSGQGKVYQLISRRRFQQMEVLEGQNILVTISGKKNRVRVYYLSWLKSKILRTDGLSDQVERRNGWINVG-DLQGAVHFKIVKYERIKFLVIALKDSIEIYAWAPKPYHKFMAFKNFGELEHRPLLVDLTIEDQSRLKVIYGSAEGFHAVDLDSAEVYDIYLPKHTQGAIIPHCIVALPNSNGMQLLLCYDNEGVYVNTVGRVSKNIVLQWGEMPTSVAYIGTGQIMGWGNKAIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKVFFSSAKGASSCQIYFMTL 1094
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Fly
Match: msn (gene:FBgn0010909 transcript:FBtr0333363)

HSP 1 Score: 404.831 bits (1039), Expect = 8.572e-120
Identity = 188/263 (71.48%), Postives = 225/263 (85.55%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHE 985
            +L +LKDPAGIF LIE+VG GTYG VYKG+  KTG LAAIKVM++T+ E+EEI LEIN L++ S+H N+A YYGAF+K       D LWLVME+CGAGS+TDLV+ST+  SLKE+WIAYI REIL+GLSYLH+N VIHRDIKGQNVLL DNAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD RSDLWSL IT++EMAE +PPLC++HPMRALFLI RN PP+LKS+KWS  FH F++  L+K++H+
Sbjct:   21 DLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDTVLVKDYHQ 283

HSP 2 Score: 323.168 bits (827), Expect = 2.347e-91
Identity = 155/331 (46.83%), Postives = 225/331 (67.98%), Query Frame = 2 
Query: 3278 VPLSALAGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMK----SDTQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
             P S  A N   ++   KK+F  EI  A  WG N L+G+E+GL  +DR+ Q KV +L+++R+F Q++VLE   I+++ISGK++R+R+Y L WLK+KI++    SD  E + GW N+G DL+    FK V +E I FLVI+LK+ I++YAWAP+P  KFM +K    L  +PLL++L+I  +S   V+Y + +GF+A+DL S   Y++Y+P+H    I PHCIV +PNS+GM LLLCY+ EGVYV+  G V K++VLQWGE+P SV +    QI+ WG KAIEIR V +G + G+F HK+  + KFL E+N+KV FS+ + ++S  I  + L
Sbjct:  764 TPTSHEAANDTPEIRKYKKRFNSEILCAALWGVNLLIGTENGLMLLDRSGQGKVYQLISRRRFQQMEVLEGQNILVTISGKKNRVRVYYLSWLKSKILRTDGLSDQVERRNGWINVG-DLQGAVHFKIVKYERIKFLVIALKDSIEIYAWAPKPYHKFMAFKNFGELEHRPLLVDLTIEDQSRLKVIYGSAEGFHAVDLDSAEVYDIYLPKHTQGAIIPHCIVALPNSNGMQLLLCYDNEGVYVNTVGRVSKNIVLQWGEMPTSVAYIGTGQIMGWGNKAIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKVFFSSAKGASSCQIYFMTL 1093
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Fly
Match: msn (gene:FBgn0010909 transcript:FBtr0333365)

HSP 1 Score: 405.216 bits (1040), Expect = 4.964e-119
Identity = 188/263 (71.48%), Postives = 225/263 (85.55%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHE 985
            +L +LKDPAGIF LIE+VG GTYG VYKG+  KTG LAAIKVM++T+ E+EEI LEIN L++ S+H N+A YYGAF+K       D LWLVME+CGAGS+TDLV+ST+  SLKE+WIAYI REIL+GLSYLH+N VIHRDIKGQNVLL DNAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD RSDLWSL IT++EMAE +PPLC++HPMRALFLI RN PP+LKS+KWS  FH F++  L+K++H+
Sbjct:   21 DLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDTVLVKDYHQ 283

HSP 2 Score: 322.783 bits (826), Expect = 9.672e-91
Identity = 155/331 (46.83%), Postives = 225/331 (67.98%), Query Frame = 2 
Query: 3278 VPLSALAGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMK----SDTQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
             P S  A N   ++   KK+F  EI  A  WG N L+G+E+GL  +DR+ Q KV +L+++R+F Q++VLE   I+++ISGK++R+R+Y L WLK+KI++    SD  E + GW N+G DL+    FK V +E I FLVI+LK+ I++YAWAP+P  KFM +K    L  +PLL++L+I  +S   V+Y + +GF+A+DL S   Y++Y+P+H    I PHCIV +PNS+GM LLLCY+ EGVYV+  G V K++VLQWGE+P SV +    QI+ WG KAIEIR V +G + G+F HK+  + KFL E+N+KV FS+ + ++S  I  + L
Sbjct:  863 TPTSHEAANDTPEIRKYKKRFNSEILCAALWGVNLLIGTENGLMLLDRSGQGKVYQLISRRRFQQMEVLEGQNILVTISGKKNRVRVYYLSWLKSKILRTDGLSDQVERRNGWINVG-DLQGAVHFKIVKYERIKFLVIALKDSIEIYAWAPKPYHKFMAFKNFGELEHRPLLVDLTIEDQSRLKVIYGSAEGFHAVDLDSAEVYDIYLPKHTQGAIIPHCIVALPNSNGMQLLLCYDNEGVYVNTVGRVSKNIVLQWGEMPTSVAYIGTGQIMGWGNKAIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKVFFSSAKGASSCQIYFMTL 1192
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Fly
Match: msn (gene:FBgn0010909 transcript:FBtr0072957)

HSP 1 Score: 405.216 bits (1040), Expect = 4.964e-119
Identity = 188/263 (71.48%), Postives = 225/263 (85.55%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHE 985
            +L +LKDPAGIF LIE+VG GTYG VYKG+  KTG LAAIKVM++T+ E+EEI LEIN L++ S+H N+A YYGAF+K       D LWLVME+CGAGS+TDLV+ST+  SLKE+WIAYI REIL+GLSYLH+N VIHRDIKGQNVLL DNAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD RSDLWSL IT++EMAE +PPLC++HPMRALFLI RN PP+LKS+KWS  FH F++  L+K++H+
Sbjct:   21 DLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDTVLVKDYHQ 283

HSP 2 Score: 322.783 bits (826), Expect = 9.672e-91
Identity = 155/331 (46.83%), Postives = 225/331 (67.98%), Query Frame = 2 
Query: 3278 VPLSALAGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMK----SDTQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
             P S  A N   ++   KK+F  EI  A  WG N L+G+E+GL  +DR+ Q KV +L+++R+F Q++VLE   I+++ISGK++R+R+Y L WLK+KI++    SD  E + GW N+G DL+    FK V +E I FLVI+LK+ I++YAWAP+P  KFM +K    L  +PLL++L+I  +S   V+Y + +GF+A+DL S   Y++Y+P+H    I PHCIV +PNS+GM LLLCY+ EGVYV+  G V K++VLQWGE+P SV +    QI+ WG KAIEIR V +G + G+F HK+  + KFL E+N+KV FS+ + ++S  I  + L
Sbjct:  863 TPTSHEAANDTPEIRKYKKRFNSEILCAALWGVNLLIGTENGLMLLDRSGQGKVYQLISRRRFQQMEVLEGQNILVTISGKKNRVRVYYLSWLKSKILRTDGLSDQVERRNGWINVG-DLQGAVHFKIVKYERIKFLVIALKDSIEIYAWAPKPYHKFMAFKNFGELEHRPLLVDLTIEDQSRLKVIYGSAEGFHAVDLDSAEVYDIYLPKHTQGAIIPHCIVALPNSNGMQLLLCYDNEGVYVNTVGRVSKNIVLQWGEMPTSVAYIGTGQIMGWGNKAIEIRSVESGHLDGVFMHKKAQRLKFLCERNDKVFFSSAKGASSCQIYFMTL 1192
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Zebrafish
Match: tnikb (TRAF2 and NCK interacting kinase b [Source:ZFIN;Acc:ZDB-GENE-051113-320])

HSP 1 Score: 400.208 bits (1027), Expect = 1.966e-124
Identity = 182/268 (67.91%), Postives = 223/268 (83.21%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T  E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDL+++T+ NSLKE+W AYI REIL+GL++LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD +SDLWSL IT+IEMAEG PPLC++HPMRALFLI RNP P+LKS+KWS  F  F+E  L+KN ++  +T+
Sbjct:   14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKAEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNSLKEEWTAYICREILRGLTHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHNQRPSTE 281

HSP 2 Score: 51.6026 bits (122), Expect = 7.601e-6
Identity = 22/31 (70.97%), Postives = 27/31 (87.10%), Query Frame = 3 
Query: 2208 RPVTEQLIQHSFVKHLPTERKVRIEIKDHID 2300
            RP TEQLI+H F+K LP ER+VRI++KDHID
Sbjct:  277 RPSTEQLIKHPFIKDLPNERQVRIQLKDHID 307
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Zebrafish
Match: tnikb (TRAF2 and NCK interacting kinase b [Source:ZFIN;Acc:ZDB-GENE-051113-320])

HSP 1 Score: 396.356 bits (1017), Expect = 4.732e-123
Identity = 181/267 (67.79%), Postives = 221/267 (82.77%), Query Frame = 2 
Query:  206 LESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            L + +DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T  E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDL+++T+ NSLKE+W AYI REIL+GL++LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD +SDLWSL IT+IEMAEG PPLC++HPMRALFLI RNP P+LKS+KWS  F  F+E  L+KN ++  +T+
Sbjct:   15 LTAERDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKAEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNSLKEEWTAYICREILRGLTHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHNQRPSTE 281

HSP 2 Score: 51.6026 bits (122), Expect = 7.866e-6
Identity = 22/31 (70.97%), Postives = 27/31 (87.10%), Query Frame = 3 
Query: 2208 RPVTEQLIQHSFVKHLPTERKVRIEIKDHID 2300
            RP TEQLI+H F+K LP ER+VRI++KDHID
Sbjct:  277 RPSTEQLIKHPFIKDLPNERQVRIQLKDHID 307
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Zebrafish
Match: si:zfos-2326c3.2 (si:zfos-2326c3.2 [Source:ZFIN;Acc:ZDB-GENE-091113-25])

HSP 1 Score: 393.66 bits (1010), Expect = 5.259e-116
Identity = 181/261 (69.35%), Postives = 221/261 (84.67%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNF 979
            +L SL+DPAGIF LIE+VG GTYG VYKG+ +KTG LAAIKVM++T+ E++EI LEIN L+  S H N+A YYGAFVK   A   D LWLVME+CGAGS+TDL++ T+ N LKEDWIAY+ RE+L+GL +LH+++VIHRDIKGQNVLL +NAE+KLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP+STYD RSD+WSL IT++EMAEG PPLC++HPMRALFLI RNPPPKLKS+K+ T    F++  L+KN+
Sbjct:   14 DLASLRDPAGIFELIEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEDEIKLEINMLKTHSHHRNIATYYGAFVKKSPAGQDDQLWLVMEYCGAGSVTDLLKKTKGNCLKEDWIAYVCREVLRGLLHLHSHHVIHRDIKGQNVLLTENAEIKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDSTYDYRSDVWSLGITALEMAEGVPPLCDMHPMRALFLIPRNPPPKLKSKKFQT----FVDSCLVKNY 270

HSP 2 Score: 315.849 bits (808), Expect = 4.851e-89
Identity = 147/311 (47.27%), Postives = 215/311 (69.13%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KKKF  EI  A+ WG N LVG+E+GL  +DR+ Q KV  L+++R+F Q+DVLE + ++++ISGK+++LR+Y L WL+NKI+ +D + E K GW ++G DLE    +K V +E I FLVI+L+N ++VYAWAP+P  KFM +K   +LP+KPL ++L++       V+Y +  GF+AID+ S   ++LY+P H+   I+PH I+ +P+S GM LLLCY  EGVY+D  G + K+ VLQWGE+P SV +   NQ++ WG KAIE+R    G + G+F HK+  K KFL E+N+KV F++V+S  S  I  + L
Sbjct:  746 KKKFNAEILCASLWGVNLLVGTENGLWLLDRSGQGKVYSLISRRRFQQMDVLEGLNVLITISGKKNKLRLYYLSWLRNKILHNDPEVEKKQGWTSVG-DLEGCVSYKVVRYEKIKFLVIALRNAVEVYAWAPKPYHKFMAFKSFSSLPQKPLSVDLTVENGQRLKVIYGSHNGFHAIDVDSGTPFDLYLPSHIQGLIRPHAIIILPSSSGMELLLCYEDEGVYIDTYGRITKETVLQWGEMPASVAYLQANQVMGWGEKAIELRSAKTGSLEGVFMHKKAQKLKFLCERNDKVFFASVQSGGSSQIYFMTL 1055
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Zebrafish
Match: tnika (TRAF2 and NCK interacting kinase a [Source:ZFIN;Acc:ZDB-GENE-030131-3767])

HSP 1 Score: 392.889 bits (1008), Expect = 5.857e-114
Identity = 181/262 (69.08%), Postives = 219/262 (83.59%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFH 982
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIK M++T  E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDL+++T+ NSLKEDW AYISREIL+GL++LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT  +RNTFIGTPYWMAPEVI C+ENP++TYD +SDLWSL IT++EMAEG PPLCE+HPMRALFLI RN PP+LKS+KW+  FH F+E  L+KN +
Sbjct:   14 DLSTLRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKCMDVTGEEEEEIKAEINMLKKYSHHRNIATYYGAFIKKNPPGVDDQLWLVMEFCGAGSVTDLIKNTKGNSLKEDWTAYISREILRGLTHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVSRRNTFIGTPYWMAPEVIACDENPDATYDYKSDLWSLGITALEMAEGAPPLCELHPMRALFLIPRNAPPRLKSKKWTKRFHSFIESCLVKNHN 275

HSP 2 Score: 316.235 bits (809), Expect = 5.002e-88
Identity = 147/311 (47.27%), Postives = 213/311 (68.49%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KK+F  EI  A  WG N LVG+E+GL  +DR+ Q KV  L+ +R+F Q+DVLE + ++++ISGK+++LR+Y L WL+N+I+ +D + E K GW  +GE LE    +K V +E I FLVI+LKN +++YAWAP+P  KFM +K    L  +P L++L++ +     V+Y ++ GF+ ID+ S   Y++YIP H+ + + PH IV +P +DGM +LLCY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VRS  S  +  + L
Sbjct:  986 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLITRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGE-LEGCIHYKVVKYERIKFLVIALKNSVEIYAWAPKPYHKFMAFKSFTELQHRPQLVDLTVEEGQRLKVIYGSSVGFHVIDVDSGSPYDIYIPSHIQSTVTPHAIVVLPKTDGMEMLLCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1295
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Zebrafish
Match: tnika (TRAF2 and NCK interacting kinase a [Source:ZFIN;Acc:ZDB-GENE-030131-3767])

HSP 1 Score: 392.889 bits (1008), Expect = 1.132e-113
Identity = 181/262 (69.08%), Postives = 219/262 (83.59%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFH 982
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIK M++T  E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDL+++T+ NSLKEDW AYISREIL+GL++LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT  +RNTFIGTPYWMAPEVI C+ENP++TYD +SDLWSL IT++EMAEG PPLCE+HPMRALFLI RN PP+LKS+KW+  FH F+E  L+KN +
Sbjct:   14 DLSTLRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKCMDVTGEEEEEIKAEINMLKKYSHHRNIATYYGAFIKKNPPGVDDQLWLVMEFCGAGSVTDLIKNTKGNSLKEDWTAYISREILRGLTHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVSRRNTFIGTPYWMAPEVIACDENPDATYDYKSDLWSLGITALEMAEGAPPLCELHPMRALFLIPRNAPPRLKSKKWTKRFHSFIESCLVKNHN 275

HSP 2 Score: 316.62 bits (810), Expect = 6.164e-88
Identity = 147/311 (47.27%), Postives = 213/311 (68.49%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KK+F  EI  A  WG N LVG+E+GL  +DR+ Q KV  L+ +R+F Q+DVLE + ++++ISGK+++LR+Y L WL+N+I+ +D + E K GW  +GE LE    +K V +E I FLVI+LKN +++YAWAP+P  KFM +K    L  +P L++L++ +     V+Y ++ GF+ ID+ S   Y++YIP H+ + + PH IV +P +DGM +LLCY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VRS  S  +  + L
Sbjct: 1015 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLITRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGE-LEGCIHYKVVKYERIKFLVIALKNSVEIYAWAPKPYHKFMAFKSFTELQHRPQLVDLTVEEGQRLKVIYGSSVGFHVIDVDSGSPYDIYIPSHIQSTVTPHAIVVLPKTDGMEMLLCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1324
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Xenopus
Match: limk1 (LIM domain kinase 1 [Source:Xenbase;Acc:XB-GENE-1011258])

HSP 1 Score: 392.889 bits (1008), Expect = 6.734e-118
Identity = 188/276 (68.12%), Postives = 227/276 (82.25%), Query Frame = 2 
Query:  176 SINFFEMIKNLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITT 997
            SIN  ++  +   L++PAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM +T+ E+EEI LEIN L++ S H N+A YYGAFV+   A   D LWLVME+CGAGS+TDLV+ T+ N  KEDWIAYI RE+L+GL++LHA++VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP+STYD RSDLWSL IT+IEMAEG PPLC++HPMRALFLI RNPPPKLKSRKWS    +F++  L+KN+    +T
Sbjct:   11 SINSLKLT-HFSLLQEPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMNVTEEEEEEIKLEINMLKKYSHHRNIATYYGAFVRKGLAGQDDQLWLVMEYCGAGSVTDLVKKTKGNCFKEDWIAYICREVLRGLAHLHAHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDSTYDYRSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSRKWSKKCINFVDSCLVKNYSHRPST 285

HSP 2 Score: 305.064 bits (780), Expect = 4.588e-87
Identity = 145/311 (46.62%), Postives = 209/311 (67.20%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KKKF  EI  A  WG N LVG+E GL  +DR+ Q +V  L+++R+F Q+DVLE + I+++ISGK+++LR+Y L WL+NKI+++D   E + GW ++G DLE    +K V +E I FLVI+LKN ++VYAWAP+P  KFM +K   +L  KPL ++L++       V+Y +  GF+AID+ S   Y+LY+P H+   I PH I+ +PN++GM LL+ Y  EGVY+D  G   K+ +LQWGE+P SV +  +NQI+ WG KAIE+R    G + G+F HK+  K KFL E+N+KV FS+V+S     I  + L
Sbjct:  505 KKKFNSEILCAALWGVNLLVGTEHGLWLLDRSGQGRVYPLISRRRFYQMDVLEGLNILITISGKKNKLRVYYLSWLRNKILRNDPDVEKRQGWVSVG-DLEGCVHYKVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFSSLHHKPLFVDLTVENGQRLKVIYGSAVGFHAIDVDSGTAYDLYLPTHMQGNIHPHAIIILPNTNGMELLVSYEDEGVYIDTYGRFTKETILQWGEMPASVAYLQSNQIMGWGEKAIELRSGETGSLEGVFMHKKAQKLKFLCERNDKVFFSSVQSGGCSQIYFMTL 814
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Xenopus
Match: limk1 (LIM domain kinase 1 [Source:Xenbase;Acc:XB-GENE-1011258])

HSP 1 Score: 392.119 bits (1006), Expect = 1.171e-117
Identity = 188/276 (68.12%), Postives = 227/276 (82.25%), Query Frame = 2 
Query:  176 SINFFEMIKNLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITT 997
            SIN  ++  +   L++PAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM +T+ E+EEI LEIN L++ S H N+A YYGAFV+   A   D LWLVME+CGAGS+TDLV+ T+ N  KEDWIAYI RE+L+GL++LHA++VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP+STYD RSDLWSL IT+IEMAEG PPLC++HPMRALFLI RNPPPKLKSRKWS    +F++  L+KN+    +T
Sbjct:   11 SINSLKLT-HFSLLQEPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMNVTEEEEEEIKLEINMLKKYSHHRNIATYYGAFVRKGLAGQDDQLWLVMEYCGAGSVTDLVKKTKGNCFKEDWIAYICREVLRGLAHLHAHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDSTYDYRSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSRKWSKKCINFVDSCLVKNYSHRPST 285

HSP 2 Score: 305.064 bits (780), Expect = 5.488e-87
Identity = 145/311 (46.62%), Postives = 209/311 (67.20%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KKKF  EI  A  WG N LVG+E GL  +DR+ Q +V  L+++R+F Q+DVLE + I+++ISGK+++LR+Y L WL+NKI+++D   E + GW ++G DLE    +K V +E I FLVI+LKN ++VYAWAP+P  KFM +K   +L  KPL ++L++       V+Y +  GF+AID+ S   Y+LY+P H+   I PH I+ +PN++GM LL+ Y  EGVY+D  G   K+ +LQWGE+P SV +  +NQI+ WG KAIE+R    G + G+F HK+  K KFL E+N+KV FS+V+S     I  + L
Sbjct:  504 KKKFNSEILCAALWGVNLLVGTEHGLWLLDRSGQGRVYPLISRRRFYQMDVLEGLNILITISGKKNKLRVYYLSWLRNKILRNDPDVEKRQGWVSVG-DLEGCVHYKVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFSSLHHKPLFVDLTVENGQRLKVIYGSAVGFHAIDVDSGTAYDLYLPTHMQGNIHPHAIIILPNTNGMELLVSYEDEGVYIDTYGRFTKETILQWGEMPASVAYLQSNQIMGWGEKAIELRSGETGSLEGVFMHKKAQKLKFLCERNDKVFFSSVQSGGCSQIYFMTL 813
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Xenopus
Match: limk1 (LIM domain kinase 1 [Source:Xenbase;Acc:XB-GENE-1011258])

HSP 1 Score: 391.734 bits (1005), Expect = 7.788e-117
Identity = 185/263 (70.34%), Postives = 221/263 (84.03%), Query Frame = 2 
Query:  215 LKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITT 997
            L++PAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM +T+ E+EEI LEIN L++ S H N+A YYGAFV+   A   D LWLVME+CGAGS+TDLV+ T+ N  KEDWIAYI RE+L+GL++LHA++VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP+STYD RSDLWSL IT+IEMAEG PPLC++HPMRALFLI RNPPPKLKSRKWS    +F++  L+KN+    +T
Sbjct:   19 LQEPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMNVTEEEEEEIKLEINMLKKYSHHRNIATYYGAFVRKGLAGQDDQLWLVMEYCGAGSVTDLVKKTKGNCFKEDWIAYICREVLRGLAHLHAHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDSTYDYRSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSRKWSKKCINFVDSCLVKNYSHRPST 281

HSP 2 Score: 305.064 bits (780), Expect = 1.770e-86
Identity = 145/311 (46.62%), Postives = 209/311 (67.20%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KKKF  EI  A  WG N LVG+E GL  +DR+ Q +V  L+++R+F Q+DVLE + I+++ISGK+++LR+Y L WL+NKI+++D   E + GW ++G DLE    +K V +E I FLVI+LKN ++VYAWAP+P  KFM +K   +L  KPL ++L++       V+Y +  GF+AID+ S   Y+LY+P H+   I PH I+ +PN++GM LL+ Y  EGVY+D  G   K+ +LQWGE+P SV +  +NQI+ WG KAIE+R    G + G+F HK+  K KFL E+N+KV FS+V+S     I  + L
Sbjct:  567 KKKFNSEILCAALWGVNLLVGTEHGLWLLDRSGQGRVYPLISRRRFYQMDVLEGLNILITISGKKNKLRVYYLSWLRNKILRNDPDVEKRQGWVSVG-DLEGCVHYKVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFSSLHHKPLFVDLTVENGQRLKVIYGSAVGFHAIDVDSGTAYDLYLPTHMQGNIHPHAIIILPNTNGMELLVSYEDEGVYIDTYGRFTKETILQWGEMPASVAYLQSNQIMGWGEKAIELRSGETGSLEGVFMHKKAQKLKFLCERNDKVFFSSVQSGGCSQIYFMTL 876
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Xenopus
Match: limk1 (LIM domain kinase 1 [Source:Xenbase;Acc:XB-GENE-1011258])

HSP 1 Score: 392.119 bits (1006), Expect = 5.016e-115
Identity = 188/276 (68.12%), Postives = 227/276 (82.25%), Query Frame = 2 
Query:  176 SINFFEMIKNLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITT 997
            SIN  ++  +   L++PAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM +T+ E+EEI LEIN L++ S H N+A YYGAFV+   A   D LWLVME+CGAGS+TDLV+ T+ N  KEDWIAYI RE+L+GL++LHA++VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP+STYD RSDLWSL IT+IEMAEG PPLC++HPMRALFLI RNPPPKLKSRKWS    +F++  L+KN+    +T
Sbjct:   11 SINSLKLT-HFSLLQEPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMNVTEEEEEEIKLEINMLKKYSHHRNIATYYGAFVRKGLAGQDDQLWLVMEYCGAGSVTDLVKKTKGNCFKEDWIAYICREVLRGLAHLHAHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDSTYDYRSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSRKWSKKCINFVDSCLVKNYSHRPST 285

HSP 2 Score: 303.908 bits (777), Expect = 1.045e-84
Identity = 145/311 (46.62%), Postives = 209/311 (67.20%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KKKF  EI  A  WG N LVG+E GL  +DR+ Q +V  L+++R+F Q+DVLE + I+++ISGK+++LR+Y L WL+NKI+++D   E + GW ++G DLE    +K V +E I FLVI+LKN ++VYAWAP+P  KFM +K   +L  KPL ++L++       V+Y +  GF+AID+ S   Y+LY+P H+   I PH I+ +PN++GM LL+ Y  EGVY+D  G   K+ +LQWGE+P SV +  +NQI+ WG KAIE+R    G + G+F HK+  K KFL E+N+KV FS+V+S     I  + L
Sbjct:  776 KKKFNSEILCAALWGVNLLVGTEHGLWLLDRSGQGRVYPLISRRRFYQMDVLEGLNILITISGKKNKLRVYYLSWLRNKILRNDPDVEKRQGWVSVG-DLEGCVHYKVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFSSLHHKPLFVDLTVENGQRLKVIYGSAVGFHAIDVDSGTAYDLYLPTHMQGNIHPHAIIILPNTNGMELLVSYEDEGVYIDTYGRFTKETILQWGEMPASVAYLQSNQIMGWGEKAIELRSGETGSLEGVFMHKKAQKLKFLCERNDKVFFSSVQSGGCSQIYFMTL 1085
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Xenopus
Match: MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4 [Source:NCBI gene;Acc:100491719])

HSP 1 Score: 387.882 bits (995), Expect = 7.234e-113
Identity = 190/263 (72.24%), Postives = 226/263 (85.93%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHE 985
            +L SL+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T+ E+EEI LEIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGSITDLV++T+ NSLKEDWIAYISREIL+GL++LHA++VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD RSDLWS  IT+IEMAEG PPLC++HPMRALFLI RNPPP+LKS+KWS  F  F+E  L+KN+ +
Sbjct:   14 DLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNSLKEDWIAYISREILRGLAHLHAHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQ 276

HSP 2 Score: 328.561 bits (841), Expect = 1.908e-92
Identity = 155/315 (49.21%), Postives = 221/315 (70.16%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINLVGRS 4270
            KK+F  EI  A  WG N LVG+ESGL  +DR+ Q KV  L+N+R+F Q+DVLE + ++++ISGK+++LR+Y L WL+NKI+ +D + E K GW  +G DLE    +K V +E I FLVI+LK+ ++VYAWAP+P  KFM +K   +L  +PLL++L++ +     V+Y +  GF+A+D+ S   Y++Y+P H+ + IQPH I+ +PN+DGM LL+CY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VRS  S  +  + L GRS
Sbjct:  866 KKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG-DLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGDLVHRPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGAVYDIYLPTHIQSSIQPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTL-GRS 1178
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Mouse
Match: Map4k4 (mitogen-activated protein kinase kinase kinase kinase 4 [Source:MGI Symbol;Acc:MGI:1349394])

HSP 1 Score: 383.259 bits (983), Expect = 6.742e-120
Identity = 189/268 (70.52%), Postives = 228/268 (85.07%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            +L SL+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T+ E+EEI LEIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGSITDLV++T+ N+LKEDWIAYISREIL+GL++LH ++VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD RSDLWS  IT+IEMAEG PPLC++HPMRALFLI RNPPP+LKS+KWS  F  F+E  L+KN+ +  +T+
Sbjct:   14 DLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTE 281
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Mouse
Match: Tnik (TRAF2 and NCK interacting kinase [Source:MGI Symbol;Acc:MGI:1916264])

HSP 1 Score: 400.593 bits (1028), Expect = 7.854e-117
Identity = 183/268 (68.28%), Postives = 222/268 (82.84%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T  E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDL+++T+ N+LKE+WIAYI REIL+GLS+LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD +SDLWSL IT+IEMAEG PPLC++HPMRALFLI RNP P+LKS+KWS  F  F+E  L+KN  +   T+
Sbjct:   14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATE 281

HSP 2 Score: 319.316 bits (817), Expect = 3.883e-89
Identity = 149/311 (47.91%), Postives = 214/311 (68.81%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KK+F  EI  A  WG N LVG+E+GL  +DR+ Q KV  L+N+R+F Q+DVLE + ++++ISGK+++LR+Y L WL+N+I+ +D + E K GW  +G DLE    +K V +E I FLVI+LKN +++YAWAP+P  KFM +K   +L  KPLL++L++ +     V++ +  GF+ ID+ S   Y++YIP H+   I PH IV +P +DGM +L+CY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VRS  S  +  + L
Sbjct:  951 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVG-DLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1260
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Mouse
Match: Tnik (TRAF2 and NCK interacting kinase [Source:MGI Symbol;Acc:MGI:1916264])

HSP 1 Score: 400.979 bits (1029), Expect = 7.940e-117
Identity = 183/268 (68.28%), Postives = 222/268 (82.84%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T  E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDL+++T+ N+LKE+WIAYI REIL+GLS+LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD +SDLWSL IT+IEMAEG PPLC++HPMRALFLI RNP P+LKS+KWS  F  F+E  L+KN  +   T+
Sbjct:   14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATE 281

HSP 2 Score: 319.316 bits (817), Expect = 4.726e-89
Identity = 149/311 (47.91%), Postives = 214/311 (68.81%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KK+F  EI  A  WG N LVG+E+GL  +DR+ Q KV  L+N+R+F Q+DVLE + ++++ISGK+++LR+Y L WL+N+I+ +D + E K GW  +G DLE    +K V +E I FLVI+LKN +++YAWAP+P  KFM +K   +L  KPLL++L++ +     V++ +  GF+ ID+ S   Y++YIP H+   I PH IV +P +DGM +L+CY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VRS  S  +  + L
Sbjct:  959 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVG-DLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1268
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Mouse
Match: Tnik (TRAF2 and NCK interacting kinase [Source:MGI Symbol;Acc:MGI:1916264])

HSP 1 Score: 400.593 bits (1028), Expect = 1.299e-116
Identity = 183/268 (68.28%), Postives = 222/268 (82.84%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T  E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDL+++T+ N+LKE+WIAYI REIL+GLS+LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD +SDLWSL IT+IEMAEG PPLC++HPMRALFLI RNP P+LKS+KWS  F  F+E  L+KN  +   T+
Sbjct:   14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATE 281

HSP 2 Score: 319.316 bits (817), Expect = 5.400e-89
Identity = 149/311 (47.91%), Postives = 214/311 (68.81%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KK+F  EI  A  WG N LVG+E+GL  +DR+ Q KV  L+N+R+F Q+DVLE + ++++ISGK+++LR+Y L WL+N+I+ +D + E K GW  +G DLE    +K V +E I FLVI+LKN +++YAWAP+P  KFM +K   +L  KPLL++L++ +     V++ +  GF+ ID+ S   Y++YIP H+   I PH IV +P +DGM +L+CY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VRS  S  +  + L
Sbjct:  980 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVG-DLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1289
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Mouse
Match: Tnik (TRAF2 and NCK interacting kinase [Source:MGI Symbol;Acc:MGI:1916264])

HSP 1 Score: 400.593 bits (1028), Expect = 1.512e-116
Identity = 183/268 (68.28%), Postives = 222/268 (82.84%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T  E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDL+++T+ N+LKE+WIAYI REIL+GLS+LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD +SDLWSL IT+IEMAEG PPLC++HPMRALFLI RNP P+LKS+KWS  F  F+E  L+KN  +   T+
Sbjct:   14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATE 281

HSP 2 Score: 319.316 bits (817), Expect = 6.778e-89
Identity = 149/311 (47.91%), Postives = 214/311 (68.81%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KK+F  EI  A  WG N LVG+E+GL  +DR+ Q KV  L+N+R+F Q+DVLE + ++++ISGK+++LR+Y L WL+N+I+ +D + E K GW  +G DLE    +K V +E I FLVI+LKN +++YAWAP+P  KFM +K   +L  KPLL++L++ +     V++ +  GF+ ID+ S   Y++YIP H+   I PH IV +P +DGM +L+CY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VRS  S  +  + L
Sbjct:  988 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVG-DLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1297
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. UniProt/SwissProt
Match: sp|P83510|TNIK_MOUSE (Traf2 and NCK-interacting protein kinase OS=Mus musculus OX=10090 GN=Tnik PE=1 SV=2)

HSP 1 Score: 400.979 bits (1029), Expect = 1.176e-115
Identity = 183/268 (68.28%), Postives = 222/268 (82.84%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T  E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDL+++T+ N+LKE+WIAYI REIL+GLS+LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD +SDLWSL IT+IEMAEG PPLC++HPMRALFLI RNP P+LKS+KWS  F  F+E  L+KN  +   T+
Sbjct:   14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATE 281

HSP 2 Score: 318.931 bits (816), Expect = 7.290e-88
Identity = 149/311 (47.91%), Postives = 214/311 (68.81%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KK+F  EI  A  WG N LVG+E+GL  +DR+ Q KV  L+N+R+F Q+DVLE + ++++ISGK+++LR+Y L WL+N+I+ +D + E K GW  +G DLE    +K V +E I FLVI+LKN +++YAWAP+P  KFM +K   +L  KPLL++L++ +     V++ +  GF+ ID+ S   Y++YIP H+   I PH IV +P +DGM +L+CY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VRS  S  +  + L
Sbjct: 1006 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVG-DLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1315
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. UniProt/SwissProt
Match: sp|Q9UKE5|TNIK_HUMAN (TRAF2 and NCK-interacting protein kinase OS=Homo sapiens OX=9606 GN=TNIK PE=1 SV=1)

HSP 1 Score: 400.979 bits (1029), Expect = 1.990e-115
Identity = 183/268 (68.28%), Postives = 222/268 (82.84%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T  E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDL+++T+ N+LKE+WIAYI REIL+GLS+LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD +SDLWSL IT+IEMAEG PPLC++HPMRALFLI RNP P+LKS+KWS  F  F+E  L+KN  +   T+
Sbjct:   14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATE 281

HSP 2 Score: 318.931 bits (816), Expect = 9.849e-88
Identity = 149/311 (47.91%), Postives = 214/311 (68.81%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KK+F  EI  A  WG N LVG+E+GL  +DR+ Q KV  L+N+R+F Q+DVLE + ++++ISGK+++LR+Y L WL+N+I+ +D + E K GW  +G DLE    +K V +E I FLVI+LKN +++YAWAP+P  KFM +K   +L  KPLL++L++ +     V++ +  GF+ ID+ S   Y++YIP H+   I PH IV +P +DGM +L+CY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VRS  S  +  + L
Sbjct: 1043 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVG-DLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTL 1352
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. UniProt/SwissProt
Match: sp|Q23356|MIG15_CAEEL (Serine/threonine-protein kinase mig-15 OS=Caenorhabditis elegans OX=6239 GN=mig-15 PE=2 SV=3)

HSP 1 Score: 390.193 bits (1001), Expect = 1.222e-113
Identity = 181/266 (68.05%), Postives = 222/266 (83.46%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA----DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLK-SRKWSTNFHDFLEKALIKNFHE 985
            +L SL+DPAGIF LIE+VG GTYG VYKG+ +KT  LAAIK+M I + E++EI LEIN L++ S H NVA YYGAF+K   ++    D LWLVMEFCG+GSITDLV++T+  SLKE+WIAYI REIL+GL +LH + VIHRDIKGQNVLL D+AEVKLVDFGVSAQLD+T G+RNTFIGTPYWMAPEVI C+E+P +TYD+RSDLWSL IT++EMAEG PPLC++HPMRALFLI RNPPPKLK ++KW+  F  F+E  L+K++H+
Sbjct:   10 DLNSLRDPAGIFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNINEDEEDEIKLEINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRNPPPKLKRNKKWTKKFETFIETVLVKDYHQ 275

HSP 2 Score: 303.523 bits (776), Expect = 7.514e-84
Identity = 149/327 (45.57%), Postives = 214/327 (65.44%), Query Frame = 2 
Query: 3296 AGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSD------TQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            A N   ++   KKKF+ EI  A  WG N L+G++SGL  +DR+ Q KV  L+++R+F Q+ VLE   I+ +ISG++ R+R+Y L WL+ KI++++      T E + GW N+G DL+    FK V +E I FLV+ L++ I++YAWAP+P  KFM +K   +L   PL+++L++   +   VLY +T GF+AIDL S   Y++Y P        PHCIV +PNS+GM LLLCY+ EGVYV+  G + K+VVLQWGE+P+SV + S  QI+ WG KAIEIR V+ G + G+F HK+  K KFL E+N+KV FS+ +   S  I  + L
Sbjct:  763 AENDAPEIRKYKKKFSGEILCAALWGVNLLIGTDSGLMLLDRSGQGKVYPLISRRRFDQMTVLEGQNILATISGRKRRIRVYYLSWLRQKILRTEGAGSANTTEKRNGWVNVG-DLQGAIHFKIVRYERIKFLVVGLESSIEIYAWAPKPYHKFMSFKSFGSLSHVPLIVDLTVEDNARLKVLYGSTGGFHAIDLDSAAVYDIYTPAQSGQTTTPHCIVVLPNSNGMQLLLCYDNEGVYVNTYGRMTKNVVLQWGEMPSSVAYISTGQIMGWGNKAIEIRSVDTGHLDGVFMHKKAQKLKFLCERNDKVFFSSAKGGGSCQIYFMTL 1088
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. UniProt/SwissProt
Match: sp|Q9JM52|MINK1_MOUSE (Misshapen-like kinase 1 OS=Mus musculus OX=10090 GN=Mink1 PE=1 SV=3)

HSP 1 Score: 394.43 bits (1012), Expect = 1.413e-113
Identity = 184/261 (70.50%), Postives = 222/261 (85.06%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNF 979
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T+ E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDLV++T+ N+LKED IAYI REIL+GL++LHA+ VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD RSD+WSL IT+IEMAEG PPLC++HPMRALFLI RNPPP+LKS+KWS  F DF++  LIK +
Sbjct:   14 DLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFTDFIDTCLIKTY 274

HSP 2 Score: 332.028 bits (850), Expect = 2.716e-92
Identity = 153/327 (46.79%), Postives = 225/327 (68.81%), Query Frame = 2 
Query: 3281 PLSALAGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            P +  A +   ++   KK+F  EI  A  WG N LVG+E+GL  +DR+ Q KV  L+ +R+F Q+DVLE + ++++ISGKR++LR+Y L WL+NKI+ +D + E K GW  +G D+E    ++ V +E I FLVI+LKN ++VYAWAP+P  KFM +K   +LP +PLL++L++ +     V+Y ++ GF+A+D+ S   Y++YIP H+ + I PH I+ +PN+DGM +LLCY  EGVYV+  G ++KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VRS  S  +  + L
Sbjct:  975 PTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG-DMEGCGHYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTL 1300
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. UniProt/SwissProt
Match: sp|Q8N4C8|MINK1_HUMAN (Misshapen-like kinase 1 OS=Homo sapiens OX=9606 GN=MINK1 PE=1 SV=2)

HSP 1 Score: 393.275 bits (1009), Expect = 5.387e-113
Identity = 184/261 (70.50%), Postives = 222/261 (85.06%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNF 979
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T+ E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDLV++T+ N+LKED IAYI REIL+GL++LHA+ VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD RSD+WSL IT+IEMAEG PPLC++HPMRALFLI RNPPP+LKS+KWS  F DF++  LIK +
Sbjct:   14 DLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTY 274

HSP 2 Score: 329.717 bits (844), Expect = 1.939e-91
Identity = 152/327 (46.48%), Postives = 225/327 (68.81%), Query Frame = 2 
Query: 3281 PLSALAGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            P +  A +   ++   KK+F  EI  A  WG N LVG+E+GL  +DR+ Q KV  L+ +R+F Q+DVLE + ++++ISGKR++LR+Y L WL+NKI+ +D + E K GW  +G D+E    ++ V +E I FLVI+LK+ ++VYAWAP+P  KFM +K   +LP +PLL++L++ +     V+Y ++ GF+A+D+ S   Y++YIP H+ + I PH I+ +PN+DGM +LLCY  EGVYV+  G ++KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VRS  S  +  + L
Sbjct:  999 PTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG-DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTL 1324
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. TrEMBL
Match: A0A5E4QA78 (Protein kinase domain-containing protein OS=Leptidea sinapis OX=189913 GN=LSINAPIS_LOCUS6159 PE=3 SV=1)

HSP 1 Score: 415.231 bits (1066), Expect = 1.191e-129
Identity = 189/263 (71.86%), Postives = 225/263 (85.55%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHE 985
            +L +LKDPAGIF LIE+VG GTYG VYKG+  KTG LAAIKVM++TQ E+EEI LEIN L++ S+H N+A YYGAF+K       D LWLVME+CGAGS+TDLV+ST+  SLKE+WI+YI REIL+GLSYLH+N VIHRDIKGQNVLL DNAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP +TYD RSDLWSL IT++EMAE +PPLC++HPMRALFLI RNPPP+LKS+KW+  FH F+E  L+K++H+
Sbjct:   17 DLGALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTQDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWISYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPEATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNPPPRLKSKKWTKKFHGFIETVLVKDYHQ 279
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. TrEMBL
Match: A0A183QJJ9 (Protein kinase domain-containing protein OS=Schistosoma rodhaini OX=6188 PE=4 SV=1)

HSP 1 Score: 416.772 bits (1070), Expect = 2.819e-127
Identity = 195/272 (71.69%), Postives = 233/272 (85.66%), Query Frame = 2 
Query:  197 IKNLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLK-----SRKWSTNFHDFLEKALIKNFHEVITT 997
            I NL+ L+DP+GIFSLIE+VGKGTYGNVYKG+  +TG LAAIKVM IT+ ++EEI LEI+TL++LS+H N+A+YYGAF+K  +  D+LWL ME+CGAGS+ DL++STR  SLKEDWIAYISREIL+GL +LHAN VIHRDIKGQNVLL DNAEVKLVDFGVSAQLD+TFGKRNTFIGTPYWMAPEVI+CE++ + TYDARSD+WSL IT++EMAEGRPPLCE+HPMRALFLI RN PP+LK     SR W+  FHDF+ K L K+FH+   T
Sbjct:    9 ITNLDDLRDPSGIFSLIEVVGKGTYGNVYKGRYTRTGQLAAIKVMPITEEDEEEIKLEIDTLKKLSNHRNIASYYGAFIKKSSPRDHLWLAMEYCGAGSVADLIKSTRTKSLKEDWIAYISREILRGLMHLHANRVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDKTFGKRNTFIGTPYWMAPEVIHCEQDSSCTYDARSDIWSLGITALEMAEGRPPLCEMHPMRALFLIMRNSPPRLKQSPNGSRHWTPRFHDFVNKCLTKDFHKRPNT 280
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. TrEMBL
Match: A0A504YG90 (Serine threonine-protein kinase mig-15 OS=Fasciola gigantica OX=46835 GN=FGIG_03595 PE=3 SV=1)

HSP 1 Score: 414.461 bits (1064), Expect = 7.024e-127
Identity = 203/274 (74.09%), Postives = 234/274 (85.40%), Query Frame = 2 
Query:  173 ISINFFEMIKNLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLK-----SRKWSTNFHDFLEKALIKNF 979
            +S N  E I NL++L DP+GIFSLIE+VGKGTYGNVYKG+ ++T  LAAIKVM ITQ ++EEIILEINTLR+LS+H N+A YYGAF+K  +  D+LWLVME+CGAGS+TDLV+STR  SLKEDWIAYI REIL+GL +LH N VIHRDIKGQNVLL DNAEVKLVDFGVSAQLD+TFGKRNTFIGTPYWMAPEVI+CE++   TYDARSDLWSL IT++EMAEGRPPLCE+HPMRALFLI RNPPP+LK     SR WS  FHDF+ K L K+F
Sbjct:    1 MSNNSLE-ITNLDNLSDPSGIFSLIEVVGKGTYGNVYKGRHVRTSQLAAIKVMPITQEDEEEIILEINTLRKLSNHRNIATYYGAFIKKASPQDHLWLVMEYCGAGSVTDLVKSTRGQSLKEDWIAYICREILRGLVHLHNNRVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDKTFGKRNTFIGTPYWMAPEVIHCEQDSRCTYDARSDLWSLGITALEMAEGRPPLCEMHPMRALFLIMRNPPPRLKQAPNGSRHWSLRFHDFVNKCLTKDF 273
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. TrEMBL
Match: A0A1B6MSP4 (Protein kinase domain-containing protein (Fragment) OS=Graphocephala atropunctata OX=36148 GN=g.39535 PE=3 SV=1)

HSP 1 Score: 406.371 bits (1043), Expect = 6.179e-126
Identity = 189/263 (71.86%), Postives = 226/263 (85.93%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHE 985
            +L +LKDPAGIF LIE+VG GTYG VYKG+  KTG LAAIKVM++T+ E+EEI LEIN L++ S+H N+A YYGAF+K       D LWLVME+CGAGS+TDLV+ST+  SLKE+WIAYI REIL+GLSYLH+N VIHRDIKGQNVLL DNAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD RSDLWSL IT++EMAE +PPLC++HPMRALFLI RNPPP+LKS+KW+  FH F+E  L+K++H+
Sbjct:   18 DLNALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNPPPRLKSKKWAKKFHGFIETVLVKDYHQ 280
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. TrEMBL
Match: A0A1B6HXX0 (Protein kinase domain-containing protein (Fragment) OS=Homalodisca liturata OX=320908 GN=g.33745 PE=3 SV=1)

HSP 1 Score: 407.142 bits (1045), Expect = 7.843e-126
Identity = 189/263 (71.86%), Postives = 226/263 (85.93%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHE 985
            +L +LKDPAGIF LIE+VG GTYG VYKG+  KTG LAAIKVM++T+ E+EEI LEIN L++ S+H N+A YYGAF+K       D LWLVME+CGAGS+TDLV+ST+  SLKE+WIAYI REIL+GLSYLH+N VIHRDIKGQNVLL DNAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD RSDLWSL IT++EMAE +PPLC++HPMRALFLI RNPPP+LKS+KW+  FH F+E  L+K++H+
Sbjct:   18 DLNALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNPPPRLKSKKWAKKFHGFIETVLVKDYHQ 280
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Cavefish
Match: MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4 [Source:NCBI gene;Acc:103041713])

HSP 1 Score: 400.593 bits (1028), Expect = 1.523e-116
Identity = 187/261 (71.65%), Postives = 222/261 (85.06%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNF 979
            +L SL+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T+ E+EEI LEIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGSITDLV++T+ N LKED IAYISREIL+GL++LHA++VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD RSDLWS  IT+IEMAEG PPLC++HPMRALFLI RNPPP+LKS+ WS  F  F+E  L+KN+
Sbjct:   14 DLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNKLKEDQIAYISREILRGLAHLHAHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKTWSKKFFSFIESCLVKNY 274

HSP 2 Score: 323.168 bits (827), Expect = 2.575e-90
Identity = 153/331 (46.22%), Postives = 225/331 (67.98%), Query Frame = 2 
Query: 3281 PLSALAGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINLVGRS 4270
            P++    +   ++   KK+F  EI  A  WG N LVG+ESGL  +DR+ Q KV  L+++R+F Q+DVLE + ++++ISGK+++LR+Y L WL+NKI+ +D + E K GW  +GE LE    +K V +E I FLV++LKN ++VYAWAP+P  KFM +K   +L  KPLL++L++ +     V+Y +  GF+A+D+ S   Y++Y+P H+ T IQ H I+ +PN+DG+ LL+CY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VR   S  +  + L GR+
Sbjct:  984 PVNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLISRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGE-LEGCVHYKVVKYERIKFLVLALKNSVEVYAWAPKPYHKFMAFKSFGDLAHKPLLVDLTVEEGQRLKVIYGSCSGFHAVDVDSGAVYDIYLPTHIQTSIQSHAIIILPNTDGIELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRQGGSSQVYFMTL-GRT 1312
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Cavefish
Match: MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4 [Source:NCBI gene;Acc:103041713])

HSP 1 Score: 400.593 bits (1028), Expect = 3.901e-116
Identity = 188/267 (70.41%), Postives = 224/267 (83.90%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITT 997
            +L SL+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T+ E+EEI LEIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGSITDLV++T+ N LKED IAYISREIL+GL++LHA++VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD RSDLWS  IT+IEMAEG PPLC++HPMRALFLI RNPPP+LKS+ WS  F  F+E  L+KN+ +   T
Sbjct:   14 DLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNKLKEDQIAYISREILRGLAHLHAHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKTWSKKFFSFIESCLVKNYTQRPPT 280

HSP 2 Score: 322.783 bits (826), Expect = 7.735e-90
Identity = 153/331 (46.22%), Postives = 225/331 (67.98%), Query Frame = 2 
Query: 3281 PLSALAGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINLVGRS 4270
            P++    +   ++   KK+F  EI  A  WG N LVG+ESGL  +DR+ Q KV  L+++R+F Q+DVLE + ++++ISGK+++LR+Y L WL+NKI+ +D + E K GW  +GE LE    +K V +E I FLV++LKN ++VYAWAP+P  KFM +K   +L  KPLL++L++ +     V+Y +  GF+A+D+ S   Y++Y+P H+ T IQ H I+ +PN+DG+ LL+CY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VR   S  +  + L GR+
Sbjct: 1057 PVNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLISRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGE-LEGCVHYKVVKYERIKFLVLALKNSVEVYAWAPKPYHKFMAFKSFGDLAHKPLLVDLTVEEGQRLKVIYGSCSGFHAVDVDSGAVYDIYLPTHIQTSIQSHAIIILPNTDGIELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRQGGSSQVYFMTL-GRT 1385
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Cavefish
Match: MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4 [Source:NCBI gene;Acc:103041713])

HSP 1 Score: 400.593 bits (1028), Expect = 4.399e-116
Identity = 187/261 (71.65%), Postives = 222/261 (85.06%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNF 979
            +L SL+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T+ E+EEI LEIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGSITDLV++T+ N LKED IAYISREIL+GL++LHA++VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD RSDLWS  IT+IEMAEG PPLC++HPMRALFLI RNPPP+LKS+ WS  F  F+E  L+KN+
Sbjct:   14 DLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNKLKEDQIAYISREILRGLAHLHAHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKTWSKKFFSFIESCLVKNY 274

HSP 2 Score: 323.168 bits (827), Expect = 6.021e-90
Identity = 153/331 (46.22%), Postives = 225/331 (67.98%), Query Frame = 2 
Query: 3281 PLSALAGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINLVGRS 4270
            P++    +   ++   KK+F  EI  A  WG N LVG+ESGL  +DR+ Q KV  L+++R+F Q+DVLE + ++++ISGK+++LR+Y L WL+NKI+ +D + E K GW  +GE LE    +K V +E I FLV++LKN ++VYAWAP+P  KFM +K   +L  KPLL++L++ +     V+Y +  GF+A+D+ S   Y++Y+P H+ T IQ H I+ +PN+DG+ LL+CY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VR   S  +  + L GR+
Sbjct: 1066 PVNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLISRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGE-LEGCVHYKVVKYERIKFLVLALKNSVEVYAWAPKPYHKFMAFKSFGDLAHKPLLVDLTVEEGQRLKVIYGSCSGFHAVDVDSGAVYDIYLPTHIQTSIQSHAIIILPNTDGIELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRQGGSSQVYFMTL-GRT 1394
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Cavefish
Match: MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4 [Source:NCBI gene;Acc:103041713])

HSP 1 Score: 400.593 bits (1028), Expect = 1.210e-115
Identity = 187/261 (71.65%), Postives = 222/261 (85.06%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNF 979
            +L SL+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T+ E+EEI LEIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGSITDLV++T+ N LKED IAYISREIL+GL++LHA++VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD RSDLWS  IT+IEMAEG PPLC++HPMRALFLI RNPPP+LKS+ WS  F  F+E  L+KN+
Sbjct:   14 DLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNKLKEDQIAYISREILRGLAHLHAHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKTWSKKFFSFIESCLVKNY 274

HSP 2 Score: 322.783 bits (826), Expect = 1.274e-89
Identity = 153/331 (46.22%), Postives = 225/331 (67.98%), Query Frame = 2 
Query: 3281 PLSALAGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINLVGRS 4270
            P++    +   ++   KK+F  EI  A  WG N LVG+ESGL  +DR+ Q KV  L+++R+F Q+DVLE + ++++ISGK+++LR+Y L WL+NKI+ +D + E K GW  +GE LE    +K V +E I FLV++LKN ++VYAWAP+P  KFM +K   +L  KPLL++L++ +     V+Y +  GF+A+D+ S   Y++Y+P H+ T IQ H I+ +PN+DG+ LL+CY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VR   S  +  + L GR+
Sbjct: 1144 PVNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLISRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGE-LEGCVHYKVVKYERIKFLVLALKNSVEVYAWAPKPYHKFMAFKSFGDLAHKPLLVDLTVEEGQRLKVIYGSCSGFHAVDVDSGAVYDIYLPTHIQTSIQSHAIIILPNTDGIELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRQGGSSQVYFMTL-GRT 1472
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BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Cavefish
Match: TNIK (TRAF2 and NCK interacting kinase [Source:HGNC Symbol;Acc:HGNC:30765])

HSP 1 Score: 392.889 bits (1008), Expect = 1.480e-114
Identity = 180/262 (68.70%), Postives = 217/262 (82.82%), Query Frame = 2 
Query:  221 DPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T  E+EEI  EIN L++ S H N+A YYGAFVK       D LWLVMEFCGAGS+TDL+++T+ NSLKE+W AYI REIL+GL++LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD +SDLWSL IT+IEMAEG PPLC++HPMRALFLI RNP P+LKS+KWS  F  F++  L+KN  +  +T+
Sbjct:   16 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKAEINMLKKYSHHRNIATYYGAFVKKNPPGIDDQLWLVMEFCGAGSVTDLIKNTKGNSLKEEWTAYICREILRGLTHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIDSCLVKNHTQRPSTE 277

HSP 2 Score: 320.472 bits (820), Expect = 9.163e-90
Identity = 149/311 (47.91%), Postives = 214/311 (68.81%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KK+F  EI  A  WG N LVG+E+GL  +DR+ Q KV  L+N+R+F Q+DVLE + ++++ISGK+++LR+Y L WL+N+I+ +D + E K GW  +G DLE    +K V +E I FLVI+LKN +++YAWAP+P  KFM +K   +L  KP L++L++ +     V+Y ++ GF+ ID+ S   Y++YIP H+   + PH IV +P +DGM +LLCY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VRS  S  +  + L
Sbjct:  900 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVG-DLEGCVHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFTDLQHKPQLVDLTVEEGQRLKVIYGSSVGFHVIDVDSGNPYDIYIPSHIQGSVTPHAIVVLPKTDGMEMLLCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLSERNDKVFFASVRSGGSSQVFFMTL 1209
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BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000169.1 (pep scaffold:Pmarinus_7.0:GL478331:850:46844:1 gene:ENSPMAG00000000147.1 transcript:ENSPMAT00000000169.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 365.155 bits (936), Expect = 5.523e-109
Identity = 170/241 (70.54%), Postives = 204/241 (84.65%), Query Frame = 2 
Query:  284 KGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            +G+ +KTG LAAIKVM++T+ E+EEI LEIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDLV++T+ NSLKEDWIAYI REIL+GLS+LHA+ VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD RSDLWSL +T+IEMAEG PPLC++HPMRALFLI RNPPP+LKS+KWS  F  F E  L+KN+ + + T+
Sbjct:    1 QGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSVTDLVKNTKGNSLKEDWIAYICREILRGLSHLHAHRVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSLGVTAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKRFLSFAESCLVKNYLQRLPTE 241
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Sea Lamprey
Match: myo3a (myosin IIIA [Source:ZFIN;Acc:ZDB-GENE-041026-4])

HSP 1 Score: 258.84 bits (660), Expect = 2.288e-70
Identity = 127/273 (46.52%), Postives = 176/273 (64.47%), Query Frame = 2 
Query:  209 ESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVME-------ITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAA-ADYLWLVMEFCGAGSITDLVRSTRYNSLKED--WIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRK-WSTNFHDFLEKALIKNFHEVIT 994
            E LKDP+  + L+E +GKGTYG VYK    K G  AA+K ++         Q   EEI  E + L  L +HPN+  ++G + + +    D LW+V+E C  GS+TDLV+       + D   IAYI R  L GL++LH++ +IHRDIKG N+LL  +  ++LVDFGVSAQ+ +T  +RNT +GTP+WMAPEVI CE+  +  YD R D+WS+ IT+IE+ +G PPL E+HPMRALF I RNPPP LK  + W   F++F+ + L+K+F    T
Sbjct:   15 EQLKDPSDTWELVETIGKGTYGKVYKATSRKDGSKAAVKTLDPVNNLETSNQDIDEEIEAEYSILTSLPEHPNIVRFFGMYYQKDGVNGDQLWIVLELCNGGSVTDLVKGQLKRGERMDVMLIAYILRGALLGLNHLHSHNIIHRDIKGNNILLTTDGGIRLVDFGVSAQVSKTRVERNTAVGTPFWMAPEVIACEQQLDYMYDRRCDVWSMGITAIELGDGDPPLYELHPMRALFKIPRNPPPTLKQPELWPPLFNEFIAQCLVKDFERRAT 287
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BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Sea Lamprey
Match: MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6865])

HSP 1 Score: 241.891 bits (616), Expect = 2.072e-66
Identity = 118/250 (47.20%), Postives = 170/250 (68.00%), Query Frame = 2 
Query:  236 FSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRN--PPPKLKSR-KWSTNFHDFLEKALIKN 976
            F L E +G GTYG+V+K + ++TG L AIK++++   +   +I +   + +   H N+ AYYG++++H    D LW+ ME CG GS+ D+   T    L E  IAY++RE LQGL+YLH+   +HRDIKG N+LL D+ +VKL DFGVSAQ+  T  KR +FIGTPYWMAPEV   E      Y+ + D+W++ IT+IE+AE +PP+ ++HPMRALFL+ ++   PPKL+ + KWS  FH+F++ AL KN
Sbjct:   14 FELAERLGSGTYGDVHKARNVQTGELVAIKIIKLEPGDDFSVIQQEIVMMKECKHTNIVAYYGSYLRH----DKLWICMEHCGGGSLQDIYHVT--GPLTERQIAYVTRETLQGLAYLHSEGKMHRDIKGANILLTDDGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVER--KGGYNHQCDVWAVGITAIELAELQPPMFDLHPMRALFLMSKSGFQPPKLRDKQKWSPVFHNFIKMALTKN 255
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Sea Lamprey
Match: stk25a (serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-GENE-041010-92])

HSP 1 Score: 212.616 bits (540), Expect = 3.297e-60
Identity = 119/259 (45.95%), Postives = 166/259 (64.09%), Query Frame = 2 
Query:  212 SLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIIL--EINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKG--QNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKN 976
            S  DP  +F+  E +GKG++G V+KG   +T  + AIK++++ + E E   +  EI  L +  D P V  Y+G+++K       LW++ME+ G GS  DL++      L+E  IA I REIL+GL YLH+   IHRDIKG   NVLL++  +VKL DFGV+ QL  T  KRNTF+GTP+WMAPEVI       S YD ++D+WSL IT+IE+A+G PP  E+HPMR LFLI +N PP L+   +S  F +F++  L K+
Sbjct:   18 SCADPEELFTKQERIGKGSFGEVFKGIDNRTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSPYVTHYFGSYLK----GTKLWIIMEYLGGGSALDLIKP---GPLEEHQIATILREILKGLDYLHSERKIHRDIKGPAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK-----QSAYDFKADIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPTLEG-NYSKAFKEFVDSCLNKD 262
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Sea Lamprey
Match: slka (STE20-like kinase a [Source:ZFIN;Acc:ZDB-GENE-050411-66])

HSP 1 Score: 222.246 bits (565), Expect = 5.183e-59
Identity = 113/254 (44.49%), Postives = 162/254 (63.78%), Query Frame = 2 
Query:  221 DPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEI-TQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLK-SRKWSTNFHDFLEKALIKN 976
            DPA ++S+I  +G G +G VYK Q  ++G+LAA KV+E  ++ E E+ ++EI  L  L DHPN+     AF       + LW+ +EFC  G++ D +       L E  I  + +++L+ L+YLH + +IHRD+K  N+LL    +VKL DFGVSA+  RT  +R++FIGTPYWMAPEV+ CE   ++ YD ++D+WSL IT IE+A+  PP  E++PMR +  I +N PP L    KWS  F DFL+K L KN
Sbjct:   28 DPAELWSVIGELGDGAFGKVYKAQNKESGVLAAAKVIETKSEEELEDYMVEIEILA-LCDHPNIVGLLNAFY----YENKLWIFIEFCPGGAV-DAIMLELERGLAEPQIRVVCKQMLEALNYLHTHRIIHRDLKAGNILLTFEGDVKLADFGVSAKNTRTLQRRDSFIGTPYWMAPEVVMCETMKDAPYDYKADIWSLGITLIELAQMEPPNHELNPMRVMLKIAKNDPPSLSFPSKWSAEFTDFLKKCLDKN 275
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144])

HSP 1 Score: 204.527 bits (519), Expect = 8.476e-54
Identity = 105/260 (40.38%), Postives = 159/260 (61.15%), Query Frame = 2 
Query:  221 DPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQH--EKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVIT 994
            D + +F   E++G+G +G VYKG  +KTG + AIKV+ +     E E++  EI  L  L    N+  YYG+++K  +    LW++ME C  GS+  L+R  +   + E +I  I RE+L  L  +H + VIHRDIK  NVL+ +   VKL DFGV+AQ+++T  +R T  GTPYWMAPEVI         YD + D+WSL IT+ E+A G PP C++  +RA+ LI ++ PP+L+ R +ST+  +F+   L ++  E ++
Sbjct:   18 DVSSLFKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTS----LWIIMEHCAGGSLRSLLRPGK---IDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIM----EGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDPKERLS 266
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931])

HSP 1 Score: 188.734 bits (478), Expect = 1.181e-51
Identity = 102/260 (39.23%), Postives = 156/260 (60.00%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIIL---EINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIK 973
            ++ S   P+ ++S+   +G+G +G+VYK     T  + AIKV+ + +H  E+I L   EI  L  L   P +  Y    ++  +    +W+VME+CG GS +DL++ +  N L E+ +++I  E+  GL YLH    IHRDIK  N+LLN+   VKL DFGVS  +  T  KR+TF+GTPYWMAPEV+ CE +    Y+ ++D+WSL IT+ E+ +G PPL +  PM+ +  + +  PPKL+   +S    DF+   L+K
Sbjct:    7 SIRSRTPPSKLYSIQSCIGRGNFGDVYKAVDRVTQEIVAIKVVNL-EHSDEDIELLAQEIFFLAELKS-PLITNYIATMLEDVS----MWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFGVSGHIRSTL-KRDTFVGTPYWMAPEVVCCEVD---GYNEKADIWSLGITTYELLKGLPPLSKYDPMKVMTNLPKRKPPKLQG-PFSDAAKDFVAGCLVK 255
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242])

HSP 1 Score: 182.57 bits (462), Expect = 1.801e-47
Identity = 102/257 (39.69%), Postives = 143/257 (55.64%), Query Frame = 2 
Query:  221 DPAGIFSLIEIVGKGTYGNVYKGQQIK-------------------TGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNS-----LKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLK 919
            DP+  F +IE  G+G  G+VY  ++                      G   AIK M +++  ++E+I+    + + S H N+  +  A+++ +   D LW+VMEF   GS+TD++ ++  N      L E  IAYI RE  QGL +LH  ++IHRDIK  NVLL+  A VK+ DFG  A+L     KR T +GTPYWMAPEV+   E     YD + D+WSL I +IEM EG PP     P++AL+LI  N  PKLK
Sbjct:  541 DPSQCFKVIEKAGQGASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYLRTD---DDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGTPYWMAPEVVKQRE-----YDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLK 789
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999])

HSP 1 Score: 177.948 bits (450), Expect = 9.985e-46
Identity = 97/247 (39.27%), Postives = 142/247 (57.49%), Query Frame = 2 
Query:  221 DPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKS-RKWSTNFHDFLE 958
            DP+  ++ +  +G+G  G VY   +I T +  AIK M + +  K+E+I+    + + S HPN+  +  ++V        LW++ME+   GS+TD+V    +  L E  I  + RE L GL +LH+  V+HRDIK  N+LL+   ++KL DFG  AQ++    KR T +GTPYWMAPEV+  +E     Y  + D+WSL I  IEM EG PP     P+RAL+LI  N  PKLK     S++   FL+
Sbjct:  615 DPSTKYANLVKIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKELIINEILVMKGSKHPNIVNFIDSYV----LKGDLWVIMEYMEGGSLTDVVT---HCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRKE-----YGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLD 849
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Yeast
Match: SKM1 (Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication [Source:SGD;Acc:S000005473])

HSP 1 Score: 162.155 bits (409), Expect = 1.192e-41
Identity = 91/257 (35.41%), Postives = 136/257 (52.92%), Query Frame = 2 
Query:  221 DPAGIFSLIEIVGKGTYGNVYKGQQIK-----------------TGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRS-TRYNS------LKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLK 919
            +P   F L+E  G+G  G VY  ++IK                  G   AIK + +++  K+++I+    +   S   N+  +  A++  +   + LW++ME+   G +TD++ +  R N+      L E+ +AYI +E  QGL +LH   +IHRDIK  N+LLN    VK+ DFG   +L     KR T +GTPYWMAPE++         YD + D+WSL I  IEM EG PP     P++AL+LI  N  PKL+
Sbjct:  355 NPRPYFQLVEKAGQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLSEQPKKQLIMNELLVMNDSRQENIVNFLEAYIIDD---EELWVIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRSKRATMVGTPYWMAPEIVN-----QKGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLIANNGSPKLR 603
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Nematostella
Match: EDO40961 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5T6])

HSP 1 Score: 358.992 bits (920), Expect = 7.225e-113
Identity = 169/263 (64.26%), Postives = 213/263 (80.99%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKH--EAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKR-NPPPKLKSRKWSTNFHDFLEKALIKNFH 982
            +L +LKDPAGIF L+E+VG GTYG V+KG+  +TG L AIK+M++T+ E+EEI LEIN LR+ S+H N+A YYGAF+K   +   D LWLVMEFCGAGS+TDLV++ R  +LKE+WI+YI RE+L G+S+LH N+VIHRDIKGQNVLL ++AEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+E P++TYD R D+WS+ IT+IEMAE +PPLC++HPMRALFLI R +PP     + WS  FH F+   LIK++ 
Sbjct:    9 DLAALKDPAGIFDLVEVVGNGTYGQVHKGRHKRTGQLTAIKIMDVTEDEEEEIKLEINVLRKFSNHRNIATYYGAFIKKSLQGQDDQLWLVMEFCGAGSVTDLVKTARNKALKEEWISYICREVLNGVSHLHMNHVIHRDIKGQNVLLTESAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDEQPDATYDNRCDMWSIGITAIEMAESQPPLCDMHPMRALFLIPRSDPPKLKSKKSWSKRFHHFVNTCLIKDYQ 271
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Nematostella
Match: EDO40960 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5T5])

HSP 1 Score: 270.781 bits (691), Expect = 2.405e-81
Identity = 134/314 (42.68%), Postives = 197/314 (62.74%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMK---SDTQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQE-SIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            K KF  EI     WG N L+G+E+GL  +DR+   KV +L+++R+F QIDVLE I ++++ISGKRH+LR+Y L WLK KI+K   +D    + G+  +G  +E    +K V+F  I FL ++ +NRI+VYAWAP+P  KFM +K   +L   P+L+ ++I +E S   V YA+  GF+++DL S    +LYIP  +     PH I  +P+S G  LLLC+N EGVY D  G +++   +QWGE P ++      QI+ WG KAIE+R V  G + G+F HKR    +FL E+NEK  F++ RS++S  +  + L
Sbjct:    8 KYKFRSEILCGALWGVNLLIGTETGLYLLDRSGNGKVFQLISRRRFQQIDVLEGINVLITISGKRHKLRVYYLSWLKAKILKGEEADHNRRQRGYTTVG-SIEGCVHYKVVNFHRIKFLAMASRNRIEVYAWAPKPYHKFMAFKSFPDLKHNPVLLNMTIEKENSKLKVCYASDIGFHSVDLDSAAVSDLYIPTKLQERFYPHAITPLPSSGGRELLLCFNNEGVYADTFGQLVRHATMQWGETPYAIASVGVGQIMGWGEKAIEVRAVETGLLDGVFMHKRAQTFRFLCERNEKGFFAS-RSTSSGQVYFMTL 319
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Nematostella
Match: EDO43631 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RY41])

HSP 1 Score: 276.174 bits (705), Expect = 1.106e-75
Identity = 132/270 (48.89%), Postives = 188/270 (69.63%), Query Frame = 2 
Query:  194 MIKNLESLK--DPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEA-AADYLWLVMEFCGAGSITDLVRS--TRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLK-SRKWSTNFHDFLEKALIKNFHE 985
            M K  ESL+  DP   + L+E +G+GTYG VYK + +KTG +AA KV++    + EE++ E+  L++ SDHPN+A ++GAF++ +    D LWLVME C  GS+T+LV++   +  SL+ED +AYI  E L+G+ YLH   V+HRDIKG NV+L + A+++L+DFGVS++L     K+N+ +GTP+WMAPEVI CE+  + +YD R D+WS+ IT IE+A+G  PL + HPMRALF I RN PP +K   KWS  + DF+   LIK+F E
Sbjct:    1 MGKGAESLRSLDPPVDWQLVESIGEGTYGEVYKVRNVKTGEIAAAKVIDSILEKIEEVLPELEILKKFSDHPNIAGFHGAFIQRDPNRQDQLWLVMELCRGGSVTNLVKNLIKKGKSLEEDLVAYILHETLKGVEYLHRKNVMHRDIKGANVMLTNEADIRLIDFGVSSELTNALMKKNSSVGTPFWMAPEVIACEQQLDYSYDMRCDVWSIGITGIELADGVAPLSDEHPMRALFKIPRNKPPTMKHPEKWSHEYRDFIAHCLIKDFEE 270
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Nematostella
Match: EDO42845 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0A9])

HSP 1 Score: 235.728 bits (600), Expect = 2.710e-69
Identity = 121/265 (45.66%), Postives = 171/265 (64.53%), Query Frame = 2 
Query:  209 ESL-KDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKS-RKWSTNFHDFLEKALIKNFHEVITT 997
            ESL + P  +F ++E +G+G+YG+V+K    ++G + AIK + +   + +EII EI+ +++  D P V  YYG++ K+      LW+VME+CGAGS++DL++  R  +L E+ I  + +  L+GL YLH    IHRDIK  N+LLN     KL DFGV+ QL  T  KRNT IGTP+WMAPEVI         YD  +D+WSL IT++EMAEG+PP  +IHPMRA+F+I   PPP  +   +WS +F DF+ K L+KN  E  T 
Sbjct:   14 ESLTRPPEEVFDVLEKLGEGSYGSVFKAMHKESGQVVAIKQVPV-DTDLQEIIKEISMMQQ-CDSPYVVKYYGSYFKNTD----LWIVMEYCGAGSVSDLMK-IRNKTLTEEEIKCVLKYTLKGLEYLHLRRKIHRDIKAGNILLNSEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ-----EVGYDCLADIWSLGITAMEMAEGKPPYADIHPMRAIFMIPTKPPPTFRDPGQWSEDFKDFVSKCLVKNPEERATA 266
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Nematostella
Match: EDO49047 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHW1])

HSP 1 Score: 232.261 bits (591), Expect = 2.666e-68
Identity = 118/258 (45.74%), Postives = 168/258 (65.12%), Query Frame = 2 
Query:  212 SLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNP--PPKLKSR-KWSTNFHDFLEKALIKN 976
            S  +P  +F LIE VG GTYG+V+K + I TG LAA+KV+++   +  E+I +   + +   H N+  Y GA+++     D LW+ ME+CG GSI D+   T      E  I++++ E L+GL+YLH   ++HRDIKG N+LL  N EVKL DFG+SA++  T  KR +FIGTPYWMAPE+   E      YD + D+W++ IT+IEMAE +PP+ ++HPMRAL++I +    PP LK + KWS   H F++ ALIKN
Sbjct:   10 SRGNPDKVFDLIEKVGGGTYGDVFKARVIATGDLAAVKVVKVEPGDDFELIQQEIAMMQQCRHNNIINYIGAYMRR----DKLWIGMEYCGGGSIQDVYCVT--GPCSETQISFVTVETLKGLAYLHEKSLMHRDIKGANILLTTNGEVKLADFGISARITETMKKRKSFIGTPYWMAPEMAAVER--TGGYDLKCDIWAVGITAIEMAELQPPMFDLHPMRALYIIGKKSFIPPTLKEKDKWSNEMHHFIKVALIKN 259
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Medaka
Match: TNIK (TRAF2 and NCK-interacting protein kinase [Source:NCBI gene;Acc:101166259])

HSP 1 Score: 398.667 bits (1023), Expect = 4.601e-117
Identity = 182/268 (67.91%), Postives = 223/268 (83.21%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T  E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDL+++T+ NSLKE+WIAYI REIL+GL++LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD +SDLWSL IT+IEMAEG PPLC++HPMRALFLI RNP P+LKS+KWS  F  F+E  L+K+  +  +T+
Sbjct:   14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKAEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNSLKEEWIAYICREILRGLTHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLLKSHSQRPSTE 281

HSP 2 Score: 308.916 bits (790), Expect = 2.832e-86
Identity = 143/293 (48.81%), Postives = 204/293 (69.62%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKV 4204
            KK+F  EI  A  WG N LVG+E+GL  +DR+ Q KV  L+N+R+F Q+DVLE + ++++ISGK+++LR+Y L WL+N+I+ +D + E K GW  +GE LE    +K V +E I FLVI+LKN +++YAWAP+P  KFM +K    L  +PLL++L++ +     V+Y +T GF+ ID+ S   Y++Y+P H+   + PH IV +P +DGM +LLCY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV
Sbjct:  835 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGE-LEGSVHYKVVKYERIKFLVIALKNSVEIYAWAPKPYHKFMAFKSFTELQHRPLLVDLTVEEGQRLKVIYGSTVGFHVIDVDSGNPYDIYVPSHIQGQVTPHAIVVLPKTDGMEMLLCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLTERNDKV 1126
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Medaka
Match: tnika (TRAF2 and NCK-interacting protein kinase [Source:NCBI gene;Acc:101155647])

HSP 1 Score: 391.734 bits (1005), Expect = 1.048e-116
Identity = 178/260 (68.46%), Postives = 217/260 (83.46%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKN 976
            +L +LKDPAGIF ++E+VG GTYG VYKG+ +KTG LAAIKVM++T  E+EEI  EIN L++ S++ N+A YYGAF+K       D LWLVMEFCGAGS+TDL+++T+ NSLKE+W +YI REIL+GL++LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT GKRNTFIGTPYWMAPEVI C+ENP +TYD +SD+WSL IT+IEMAEG PPLC++HPMRALFLI RNP P+LKS+KWS     F+E  L+KN
Sbjct:   14 DLSALKDPAGIFEVVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKAEINMLKKYSNNRNIATYYGAFIKKNPPGIDDQLWLVMEFCGAGSVTDLIKNTKGNSLKEEWTSYICREILRGLAHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGKRNTFIGTPYWMAPEVIACDENPAATYDFKSDVWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSRKLQSFIEFCLVKN 273
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Medaka
Match: TNIK (TRAF2 and NCK-interacting protein kinase [Source:NCBI gene;Acc:101166259])

HSP 1 Score: 399.053 bits (1024), Expect = 1.520e-115
Identity = 182/268 (67.91%), Postives = 223/268 (83.21%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAA--DYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVM++T  E+EEI  EIN L++ S H N+A YYGAF+K       D LWLVMEFCGAGS+TDL+++T+ NSLKE+WIAYI REIL+GL++LH + VIHRDIKGQNVLL +NAEVKLVDFGVSAQLDRT G+RNTFIGTPYWMAPEVI C+ENP++TYD +SDLWSL IT+IEMAEG PPLC++HPMRALFLI RNP P+LKS+KWS  F  F+E  L+K+  +  +T+
Sbjct:   14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKAEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNSLKEEWIAYICREILRGLTHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLLKSHSQRPSTE 281

HSP 2 Score: 320.857 bits (821), Expect = 2.889e-89
Identity = 149/311 (47.91%), Postives = 214/311 (68.81%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KK+F  EI  A  WG N LVG+E+GL  +DR+ Q KV  L+N+R+F Q+DVLE + ++++ISGK+++LR+Y L WL+N+I+ +D + E K GW  +GE LE    +K V +E I FLVI+LKN +++YAWAP+P  KFM +K    L  +PLL++L++ +     V+Y +T GF+ ID+ S   Y++Y+P H+   + PH IV +P +DGM +LLCY  EGVYV+  G + KDVVLQWGE+P SV +  +NQI+ WG KAIEIR V  G + G+F HKR  + KFL E+N+KV F++VRS  S  +  + L
Sbjct: 1027 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGE-LEGSVHYKVVKYERIKFLVIALKNSVEIYAWAPKPYHKFMAFKSFTELQHRPLLVDLTVEEGQRLKVIYGSTVGFHVIDVDSGNPYDIYVPSHIQGQVTPHAIVVLPKTDGMEMLLCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLTERNDKVFFASVRSGGSSQVFFMTL 1336
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Medaka
Match: ENSORLT00000011250.2 (mitogen-activated protein kinase kinase kinase kinase 4 [Source:NCBI gene;Acc:101156098])

HSP 1 Score: 394.045 bits (1011), Expect = 2.753e-115
Identity = 184/260 (70.77%), Postives = 219/260 (84.23%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAAD--YLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKN 976
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVME+T+ E+EEI LEIN L+  S H N+A YYGAFVK   A     LWLVME+CGAGS+TDLV+ T+ N  KEDWIAYI RE+L+GLS+LH+++VIHRDIKGQNVLL +NAEVKLVDFGVSAQLD+T G+RNTFIGTPYWMAPEVI C+ENP +TYD RSDLWSL IT++EMAEG PPLC++HPMRALFLI RNPPPKLKS+KWS  F  F++  L+KN
Sbjct:   14 DLAALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMEVTEEEEEEIKLEINMLKSYSHHRNIATYYGAFVKKSPAGQDHQLWLVMEYCGAGSVTDLVKKTKGNCFKEDWIAYICREVLRGLSHLHSHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDKTIGRRNTFIGTPYWMAPEVIACDENPEATYDYRSDLWSLGITALEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSKKWSKRFLSFVDSCLVKN 273

HSP 2 Score: 305.449 bits (781), Expect = 4.900e-85
Identity = 139/293 (47.44%), Postives = 205/293 (69.97%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKV 4204
            KKKF  E+  A  WG N LVG+E+GL  +DR+ Q KV  L+++R+F Q+DVLE + ++++ISGK+++LR+Y L WL+NKI+ +D + E + GW ++G DLE    +K V +E I FLV++LKN ++VYAWAP+P  KFM +K   +LP+KPL ++L++ +     V+Y ++ GF+AID+ S   Y+LY+P H+   I PH I+ +PN  G  +L+CY  EGVY+D  G + KD VLQWGE+P SV +  +NQ++ WG KAIE+R  N G + G+F HK+  K KFL E+N+KV
Sbjct:  835 KKKFNAEVLCAGLWGVNLLVGTENGLWLLDRSGQGKVYSLISRRRFQQMDVLEGLNVLITISGKKNKLRLYYLSWLRNKILHNDPEVEKRQGWTSVG-DLEGCVHYKVVRYEKIKFLVVALKNAVEVYAWAPKPYHKFMAFKSFRSLPQKPLFVDLTVEEGQRLKVIYGSSSGFHAIDVDSGTPYDLYLPTHIQGLIHPHAIIILPNKAGTEVLVCYEDEGVYIDTYGRITKDTVLQWGEMPASVAYLQSNQVMGWGEKAIELRSANTGNLEGVFMHKKAQKLKFLCERNDKV 1126
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Medaka
Match: ENSORLT00000042856.1 (mitogen-activated protein kinase kinase kinase kinase 4 [Source:NCBI gene;Acc:101156098])

HSP 1 Score: 394.43 bits (1012), Expect = 8.065e-115
Identity = 184/260 (70.77%), Postives = 219/260 (84.23%), Query Frame = 2 
Query:  203 NLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAAD--YLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKN 976
            +L +L+DPAGIF L+E+VG GTYG VYKG+ +KTG LAAIKVME+T+ E+EEI LEIN L+  S H N+A YYGAFVK   A     LWLVME+CGAGS+TDLV+ T+ N  KEDWIAYI RE+L+GLS+LH+++VIHRDIKGQNVLL +NAEVKLVDFGVSAQLD+T G+RNTFIGTPYWMAPEVI C+ENP +TYD RSDLWSL IT++EMAEG PPLC++HPMRALFLI RNPPPKLKS+KWS  F  F++  L+KN
Sbjct:   14 DLAALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMEVTEEEEEEIKLEINMLKSYSHHRNIATYYGAFVKKSPAGQDHQLWLVMEYCGAGSVTDLVKKTKGNCFKEDWIAYICREVLRGLSHLHSHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDKTIGRRNTFIGTPYWMAPEVIACDENPEATYDYRSDLWSLGITALEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSKKWSKRFLSFVDSCLVKN 273

HSP 2 Score: 317.775 bits (813), Expect = 8.942e-89
Identity = 145/311 (46.62%), Postives = 215/311 (69.13%), Query Frame = 2 
Query: 3329 KKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQ-EIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINL 4258
            KKKF  E+  A  WG N LVG+E+GL  +DR+ Q KV  L+++R+F Q+DVLE + ++++ISGK+++LR+Y L WL+NKI+ +D + E + GW ++G DLE    +K V +E I FLV++LKN ++VYAWAP+P  KFM +K   +LP+KPL ++L++ +     V+Y ++ GF+AID+ S   Y+LY+P H+   I PH I+ +PN  G  +L+CY  EGVY+D  G + KD VLQWGE+P SV +  +NQ++ WG KAIE+R  N G + G+F HK+  K KFL E+N+KV F++V+S  S  I  + L
Sbjct:  942 KKKFNAEVLCAGLWGVNLLVGTENGLWLLDRSGQGKVYSLISRRRFQQMDVLEGLNVLITISGKKNKLRLYYLSWLRNKILHNDPEVEKRQGWTSVG-DLEGCVHYKVVRYEKIKFLVVALKNAVEVYAWAPKPYHKFMAFKSFRSLPQKPLFVDLTVEEGQRLKVIYGSSSGFHAIDVDSGTPYDLYLPTHIQGLIHPHAIIILPNKAGTEVLVCYEDEGVYIDTYGRITKDTVLQWGEMPASVAYLQSNQVMGWGEKAIELRSANTGNLEGVFMHKKAQKLKFLCERNDKVFFASVQSGGSSQIYFMTL 1251
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Planmine SMEST
Match: SMESG000031711.1 (SMESG000031711.1)

HSP 1 Score: 696.812 bits (1797), Expect = 0.000e+0
Identity = 334/335 (99.70%), Postives = 334/335 (99.70%), Query Frame = 2 
Query: 3269 SIEVPLSALAGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINLVGRSW 4273
            SIEVPLSALAGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDR AQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINLVGRSW
Sbjct:  584 SIEVPLSALAGNSDDDVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRAAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSIVQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNSDGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGCKAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISMINLVGRSW 918

HSP 2 Score: 557.37 bits (1435), Expect = 0.000e+0
Identity = 308/336 (91.67%), Postives = 309/336 (91.96%), Query Frame = 3 
Query: 2178 FHDFENKMF*-----RPVTEQLIQHSFVKHLPTERKVRIEIKDHIDHFGKHKKVXXXXXXXXXXXXXXXXXXXVLPLPPPPESHQILQMTDKLRQFEFQNQLQVSVVNQPDICTLKKNFVKIQEKDGLNLKMTESNLVNQLQFIKSDDNCPINKSDENQIKVSKSISPEKLNRHVNSPKLEPKNHSPNIRKLTEANFSPKLSSNNVQLQTKSVSQKNKYVSKPKFPPTRPTSTQLSEKSEEHPTNVQRYSQMESMNVAKMSLNNLSNIKEVEDAKKLESNNQWLQEQENDLGKNSDKKCNEIMFPEEKNMESDDSLSEDEINTLAPAKKIPVSSSK 3170
            FHDF  K        RPVTEQLIQHSFVKHLPTERKVRIEIKDHIDHFGKHKKVIQPPIPQQISDDEDDDINDVLPLPPPPESHQILQMTDKLRQFEFQNQLQVSVVNQPDICTLKKNFVKIQEKDGLNLKMTESNLVNQLQ IKSDDNCPINKSDENQIKVSK                +PKNHSPNIRKLTEANFSPKLSSNNVQLQTKSVSQKNKYVSKPKFPPTRPTSTQLSEKSEEHPTNVQRYSQMESMNVAKMSLNNLSNIKEVEDAKKLESNNQWLQEQENDLGKNSDKKCNEIMFPEEKNMESDDSLSEDEINTLAPAKKIPVSSSK
Sbjct:  250 FHDFLEKALIKNFHERPVTEQLIQHSFVKHLPTERKVRIEIKDHIDHFGKHKKVIQPPIPQQISDDEDDDINDVLPLPPPPESHQILQMTDKLRQFEFQNQLQVSVVNQPDICTLKKNFVKIQEKDGLNLKMTESNLVNQLQLIKSDDNCPINKSDENQIKVSK----------------KPKNHSPNIRKLTEANFSPKLSSNNVQLQTKSVSQKNKYVSKPKFPPTRPTSTQLSEKSEEHPTNVQRYSQMESMNVAKMSLNNLSNIKEVEDAKKLESNNQWLQEQENDLGKNSDKKCNEIMFPEEKNMESDDSLSEDEINTLAPAKKIPVSSSK 569

HSP 3 Score: 557.37 bits (1435), Expect = 7.419e-178
Identity = 265/269 (98.51%), Postives = 266/269 (98.88%), Query Frame = 2 
Query:  194 MIKNLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHEVITTK 1000
            MIKNLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHE   T+
Sbjct:    1 MIKNLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNFHERPVTE 269
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Planmine SMEST
Match: SMESG000025153.1 (SMESG000025153.1)

HSP 1 Score: 435.647 bits (1119), Expect = 3.597e-131
Identity = 205/267 (76.78%), Postives = 238/267 (89.14%), Query Frame = 2 
Query:  179 INFFEMIKNLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNF 979
            ++  + I NLESLKDPAGIFSLIEIVGKGTYGNVYKG+  KTG LAAIKVM+IT+ ++EEI LEIN L+RLS+H N+A+YYGAF+K E   D+LWLVME+CGAGS+TDLV++T+  SLKEDWIAYISREIL+GL++LH N VIHRDIKGQNVLL +NAEVKLVDFGVSAQLD+T GKRNTFIGTPYWMAPEVI+CE++ NSTYDARSDLWSL ITS+EMAEGRPPLCE+HPMRALFLI RN PP+LKSRKWS  FH+F+EK L K+F
Sbjct:    1 MSLSQPIVNLESLKDPAGIFSLIEIVGKGTYGNVYKGRHNKTGQLAAIKVMQITEEDEEEIKLEINMLKRLSNHRNIASYYGAFIKKEKDQDFLWLVMEYCGAGSVTDLVKNTKGQSLKEDWIAYISREILRGLAHLHNNRVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDKTLGKRNTFIGTPYWMAPEVIHCEQDMNSTYDARSDLWSLGITSLEMAEGRPPLCEMHPMRALFLIMRNAPPRLKSRKWSPRFHEFIEKCLTKDF 267

HSP 2 Score: 163.31 bits (412), Expect = 2.782e-40
Identity = 76/165 (46.06%), Postives = 114/165 (69.09%), Query Frame = 2 
Query: 3290 ALAGNSDD--DVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKP 3778
            A + N++D  +  L KK+F  EI  A  WG N L+G E+GL  +DR+ Q KV  L+++RKF+Q+DVLE   I+++ISG ++RLR+Y L WL+ KI+KSD  + K GW N+GE+L+    FK V ++ I FLVI++K+ +++YAWAP+P  KFM +K  + L  +P
Sbjct:  899 ATSTNTEDGLETHLYKKRFGSEILCACLWGANLLIGLENGLSLLDRSGQGKVYSLISRRKFLQMDVLEGQNILVTISGSKNRLRVYFLSWLRGKILKSDGIDKKNGWVNVGENLQGAVHFKIVKYDKIKFLVIAMKDSVEIYAWAPRPYHKFMAFKKFETLQHRP 1063
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Planmine SMEST
Match: SMESG000025153.1 (SMESG000025153.1)

HSP 1 Score: 436.032 bits (1120), Expect = 8.335e-131
Identity = 205/267 (76.78%), Postives = 238/267 (89.14%), Query Frame = 2 
Query:  179 INFFEMIKNLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNF 979
            ++  + I NLESLKDPAGIFSLIEIVGKGTYGNVYKG+  KTG LAAIKVM+IT+ ++EEI LEIN L+RLS+H N+A+YYGAF+K E   D+LWLVME+CGAGS+TDLV++T+  SLKEDWIAYISREIL+GL++LH N VIHRDIKGQNVLL +NAEVKLVDFGVSAQLD+T GKRNTFIGTPYWMAPEVI+CE++ NSTYDARSDLWSL ITS+EMAEGRPPLCE+HPMRALFLI RN PP+LKSRKWS  FH+F+EK L K+F
Sbjct:    1 MSLSQPIVNLESLKDPAGIFSLIEIVGKGTYGNVYKGRHNKTGQLAAIKVMQITEEDEEEIKLEINMLKRLSNHRNIASYYGAFIKKEKDQDFLWLVMEYCGAGSVTDLVKNTKGQSLKEDWIAYISREILRGLAHLHNNRVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDKTLGKRNTFIGTPYWMAPEVIHCEQDMNSTYDARSDLWSLGITSLEMAEGRPPLCEMHPMRALFLIMRNAPPRLKSRKWSPRFHEFIEKCLTKDF 267

HSP 2 Score: 163.696 bits (413), Expect = 2.939e-40
Identity = 76/165 (46.06%), Postives = 114/165 (69.09%), Query Frame = 2 
Query: 3290 ALAGNSDD--DVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKP 3778
            A + N++D  +  L KK+F  EI  A  WG N L+G E+GL  +DR+ Q KV  L+++RKF+Q+DVLE   I+++ISG ++RLR+Y L WL+ KI+KSD  + K GW N+GE+L+    FK V ++ I FLVI++K+ +++YAWAP+P  KFM +K  + L  +P
Sbjct:  955 ATSTNTEDGLETHLYKKRFGSEILCACLWGANLLIGLENGLSLLDRSGQGKVYSLISRRKFLQMDVLEGQNILVTISGSKNRLRVYFLSWLRGKILKSDGIDKKNGWVNVGENLQGAVHFKIVKYDKIKFLVIAMKDSVEIYAWAPRPYHKFMAFKKFETLQHRP 1119
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Planmine SMEST
Match: SMESG000025153.1 (SMESG000025153.1)

HSP 1 Score: 436.417 bits (1121), Expect = 1.265e-130
Identity = 205/267 (76.78%), Postives = 238/267 (89.14%), Query Frame = 2 
Query:  179 INFFEMIKNLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNF 979
            ++  + I NLESLKDPAGIFSLIEIVGKGTYGNVYKG+  KTG LAAIKVM+IT+ ++EEI LEIN L+RLS+H N+A+YYGAF+K E   D+LWLVME+CGAGS+TDLV++T+  SLKEDWIAYISREIL+GL++LH N VIHRDIKGQNVLL +NAEVKLVDFGVSAQLD+T GKRNTFIGTPYWMAPEVI+CE++ NSTYDARSDLWSL ITS+EMAEGRPPLCE+HPMRALFLI RN PP+LKSRKWS  FH+F+EK L K+F
Sbjct:    1 MSLSQPIVNLESLKDPAGIFSLIEIVGKGTYGNVYKGRHNKTGQLAAIKVMQITEEDEEEIKLEINMLKRLSNHRNIASYYGAFIKKEKDQDFLWLVMEYCGAGSVTDLVKNTKGQSLKEDWIAYISREILRGLAHLHNNRVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDKTLGKRNTFIGTPYWMAPEVIHCEQDMNSTYDARSDLWSLGITSLEMAEGRPPLCEMHPMRALFLIMRNAPPRLKSRKWSPRFHEFIEKCLTKDF 267

HSP 2 Score: 163.31 bits (412), Expect = 3.991e-40
Identity = 76/165 (46.06%), Postives = 114/165 (69.09%), Query Frame = 2 
Query: 3290 ALAGNSDD--DVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKP 3778
            A + N++D  +  L KK+F  EI  A  WG N L+G E+GL  +DR+ Q KV  L+++RKF+Q+DVLE   I+++ISG ++RLR+Y L WL+ KI+KSD  + K GW N+GE+L+    FK V ++ I FLVI++K+ +++YAWAP+P  KFM +K  + L  +P
Sbjct:  991 ATSTNTEDGLETHLYKKRFGSEILCACLWGANLLIGLENGLSLLDRSGQGKVYSLISRRKFLQMDVLEGQNILVTISGSKNRLRVYFLSWLRGKILKSDGIDKKNGWVNVGENLQGAVHFKIVKYDKIKFLVIAMKDSVEIYAWAPRPYHKFMAFKKFETLQHRP 1155
[Close]
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Planmine SMEST
Match: SMESG000025153.1 (SMESG000025153.1)

HSP 1 Score: 435.261 bits (1118), Expect = 1.897e-130
Identity = 205/267 (76.78%), Postives = 238/267 (89.14%), Query Frame = 2 
Query:  179 INFFEMIKNLESLKDPAGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEINTLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYNSLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFGVSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITSIEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKNF 979
            ++  + I NLESLKDPAGIFSLIEIVGKGTYGNVYKG+  KTG LAAIKVM+IT+ ++EEI LEIN L+RLS+H N+A+YYGAF+K E   D+LWLVME+CGAGS+TDLV++T+  SLKEDWIAYISREIL+GL++LH N VIHRDIKGQNVLL +NAEVKLVDFGVSAQLD+T GKRNTFIGTPYWMAPEVI+CE++ NSTYDARSDLWSL ITS+EMAEGRPPLCE+HPMRALFLI RN PP+LKSRKWS  FH+F+EK L K+F
Sbjct:    1 MSLSQPIVNLESLKDPAGIFSLIEIVGKGTYGNVYKGRHNKTGQLAAIKVMQITEEDEEEIKLEINMLKRLSNHRNIASYYGAFIKKEKDQDFLWLVMEYCGAGSVTDLVKNTKGQSLKEDWIAYISREILRGLAHLHNNRVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDKTLGKRNTFIGTPYWMAPEVIHCEQDMNSTYDARSDLWSLGITSLEMAEGRPPLCEMHPMRALFLIMRNAPPRLKSRKWSPRFHEFIEKCLTKDF 267

HSP 2 Score: 163.31 bits (412), Expect = 3.601e-40
Identity = 76/165 (46.06%), Postives = 114/165 (69.09%), Query Frame = 2 
Query: 3290 ALAGNSDD--DVLLCKKKFTCEIYSATFWGNNCLVGSESGLDFIDRTAQSKVIRLVNKRKFVQIDVLEDIGIMLSISGKRHRLRMYALQWLKNKIMKSDTQEIKVGWANIGEDLENIHQFKTVSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKP 3778
            A + N++D  +  L KK+F  EI  A  WG N L+G E+GL  +DR+ Q KV  L+++RKF+Q+DVLE   I+++ISG ++RLR+Y L WL+ KI+KSD  + K GW N+GE+L+    FK V ++ I FLVI++K+ +++YAWAP+P  KFM +K  + L  +P
Sbjct:  969 ATSTNTEDGLETHLYKKRFGSEILCACLWGANLLIGLENGLSLLDRSGQGKVYSLISRRKFLQMDVLEGQNILVTISGSKNRLRVYFLSWLRGKILKSDGIDKKNGWVNVGENLQGAVHFKIVKYDKIKFLVIAMKDSVEIYAWAPRPYHKFMAFKKFETLQHRP 1133
The following BLAST results are available for this feature:
BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MINK12.300e-12170.50misshapen like kinase 1 [Source:HGNC Symbol;Acc:HG... [more]
TNIK1.018e-11668.28TRAF2 and NCK interacting kinase [Source:HGNC Symb... [more]
TNIK1.325e-11668.28TRAF2 and NCK interacting kinase [Source:HGNC Symb... [more]
TNIK1.616e-11668.28TRAF2 and NCK interacting kinase [Source:HGNC Symb... [more]
TNIK2.168e-11668.28TRAF2 and NCK interacting kinase [Source:HGNC Symb... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mig-156.169e-11568.05Serine/threonine-protein kinase mig-15 [Source:Un... [more]
mig-156.792e-11568.05Serine/threonine-protein kinase mig-15 [Source:Un... [more]
mig-158.010e-11568.05Serine/threonine-protein kinase mig-15 [Source:Un... [more]
mig-159.606e-11568.05Serine/threonine-protein kinase mig-15 [Source:Un... [more]
cst-27.178e-6747.13Caenorhabditis STE20-like kinase [Source:UniProtK... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
msn8.489e-12071.48gene:FBgn0010909 transcript:FBtr0072959[more]
msn8.489e-12071.48gene:FBgn0010909 transcript:FBtr0072958[more]
msn8.572e-12071.48gene:FBgn0010909 transcript:FBtr0333363[more]
msn4.964e-11971.48gene:FBgn0010909 transcript:FBtr0333365[more]
msn4.964e-11971.48gene:FBgn0010909 transcript:FBtr0072957[more]
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BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
tnikb1.966e-12467.91TRAF2 and NCK interacting kinase b [Source:ZFIN;Ac... [more]
tnikb4.732e-12367.79TRAF2 and NCK interacting kinase b [Source:ZFIN;Ac... [more]
si:zfos-2326c3.25.259e-11669.35si:zfos-2326c3.2 [Source:ZFIN;Acc:ZDB-GENE-091113-... [more]
tnika5.857e-11469.08TRAF2 and NCK interacting kinase a [Source:ZFIN;Ac... [more]
tnika1.132e-11369.08TRAF2 and NCK interacting kinase a [Source:ZFIN;Ac... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
limk16.734e-11868.12LIM domain kinase 1 [Source:Xenbase;Acc:XB-GENE-10... [more]
limk11.171e-11768.12LIM domain kinase 1 [Source:Xenbase;Acc:XB-GENE-10... [more]
limk17.788e-11770.34LIM domain kinase 1 [Source:Xenbase;Acc:XB-GENE-10... [more]
limk15.016e-11568.12LIM domain kinase 1 [Source:Xenbase;Acc:XB-GENE-10... [more]
MAP4K47.234e-11372.24mitogen-activated protein kinase kinase kinase kin... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Map4k46.742e-12070.52mitogen-activated protein kinase kinase kinase kin... [more]
Tnik7.854e-11768.28TRAF2 and NCK interacting kinase [Source:MGI Symbo... [more]
Tnik7.940e-11768.28TRAF2 and NCK interacting kinase [Source:MGI Symbo... [more]
Tnik1.299e-11668.28TRAF2 and NCK interacting kinase [Source:MGI Symbo... [more]
Tnik1.512e-11668.28TRAF2 and NCK interacting kinase [Source:MGI Symbo... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P83510|TNIK_MOUSE1.176e-11568.28Traf2 and NCK-interacting protein kinase OS=Mus mu... [more]
sp|Q9UKE5|TNIK_HUMAN1.990e-11568.28TRAF2 and NCK-interacting protein kinase OS=Homo s... [more]
sp|Q23356|MIG15_CAEEL1.222e-11368.05Serine/threonine-protein kinase mig-15 OS=Caenorha... [more]
sp|Q9JM52|MINK1_MOUSE1.413e-11370.50Misshapen-like kinase 1 OS=Mus musculus OX=10090 G... [more]
sp|Q8N4C8|MINK1_HUMAN5.387e-11370.50Misshapen-like kinase 1 OS=Homo sapiens OX=9606 GN... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5E4QA781.191e-12971.86Protein kinase domain-containing protein OS=Leptid... [more]
A0A183QJJ92.819e-12771.69Protein kinase domain-containing protein OS=Schist... [more]
A0A504YG907.024e-12774.09Serine threonine-protein kinase mig-15 OS=Fasciola... [more]
A0A1B6MSP46.179e-12671.86Protein kinase domain-containing protein (Fragment... [more]
A0A1B6HXX07.843e-12671.86Protein kinase domain-containing protein (Fragment... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MAP4K41.523e-11671.65mitogen-activated protein kinase kinase kinase kin... [more]
MAP4K43.901e-11670.41mitogen-activated protein kinase kinase kinase kin... [more]
MAP4K44.399e-11671.65mitogen-activated protein kinase kinase kinase kin... [more]
MAP4K41.210e-11571.65mitogen-activated protein kinase kinase kinase kin... [more]
TNIK1.480e-11468.70TRAF2 and NCK interacting kinase [Source:HGNC Symb... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000000169.15.523e-10970.54pep scaffold:Pmarinus_7.0:GL478331:850:46844:1 gen... [more]
myo3a2.288e-7046.52myosin IIIA [Source:ZFIN;Acc:ZDB-GENE-041026-4][more]
MAP4K32.072e-6647.20mitogen-activated protein kinase kinase kinase kin... [more]
stk25a3.297e-6045.95serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-G... [more]
slka5.183e-5944.49STE20-like kinase a [Source:ZFIN;Acc:ZDB-GENE-0504... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
KIC18.476e-5440.38Protein kinase of the PAK/Ste20 family, required f... [more]
SPS11.181e-5139.23Putative protein serine/threonine kinase; localize... [more]
CLA41.801e-4739.69Cdc42p-activated signal transducing kinase; member... [more]
STE209.985e-4639.27Cdc42p-activated signal transducing kinase; involv... [more]
SKM11.192e-4135.41Member of the PAK family of serine/threonine prote... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO409617.225e-11364.26Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO409602.405e-8142.68Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO436311.106e-7548.89Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO428452.710e-6945.66Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO490472.666e-6845.74Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TNIK4.601e-11767.91TRAF2 and NCK-interacting protein kinase [Source:N... [more]
tnika1.048e-11668.46TRAF2 and NCK-interacting protein kinase [Source:N... [more]
TNIK1.520e-11567.91TRAF2 and NCK-interacting protein kinase [Source:N... [more]
ENSORLT00000011250.22.753e-11570.77mitogen-activated protein kinase kinase kinase kin... [more]
ENSORLT00000042856.18.065e-11570.77mitogen-activated protein kinase kinase kinase kin... [more]
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BLAST of Mitogen-activated protein kinase kinase kinase kinase 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000031711.17.419e-17899.70SMESG000031711.1[more]
SMESG000025153.13.597e-13176.78SMESG000025153.1[more]
SMESG000025153.18.335e-13176.78SMESG000025153.1[more]
SMESG000025153.11.265e-13076.78SMESG000025153.1[more]
SMESG000025153.11.897e-13076.78SMESG000025153.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30023902 ID=SMED30023902|Name=Mitogen-activated protein kinase kinase kinase kinase 4|organism=Schmidtea mediterranea sexual|type=transcript|length=4675bp
GGATCTTTTAACGCTTTCGAAATATTATAAATTACTTAGATTCTAAGTTT
GAGAATAATAAAATAACCTAAAGTAAATGTCGCAAAGACATTTTGTTAAT
TTGCGTTATTGTATTTCTATTTGCTATTTACATAAATTATGTTTAATTCT
ATTAAAATGTATTTTAAGATATATTTCTATTAATTTTTTTGAAATGATAA
AAAATTTGGAAAGTTTAAAAGATCCAGCAGGGATATTTTCTTTGATTGAA
ATTGTTGGCAAAGGAACATACGGAAATGTTTACAAAGGTCAACAAATTAA
AACTGGTCTTCTTGCTGCAATCAAAGTCATGGAAATTACCCAACATGAAA
AAGAAGAAATAATTTTAGAGATAAATACATTAAGACGTCTTTCTGATCAT
CCAAATGTAGCTGCGTATTATGGAGCTTTTGTTAAGCATGAAGCGGCAGC
TGATTATTTATGGCTGGTAATGGAATTTTGTGGAGCTGGATCTATTACAG
ATTTAGTGCGAAGTACTAGATATAATTCGCTAAAAGAAGATTGGATTGCT
TATATAAGTAGAGAAATTTTACAGGGTCTTTCCTATCTTCATGCGAATTA
TGTCATTCACAGAGATATCAAAGGTCAAAATGTGCTTTTAAATGACAATG
CAGAAGTTAAATTAGTTGATTTCGGAGTAAGTGCACAATTGGATCGCACA
TTTGGAAAAAGAAACACATTCATTGGAACTCCGTATTGGATGGCACCCGA
AGTAATTTACTGTGAAGAAAACCCAAATAGTACGTATGATGCAAGAAGTG
ATTTATGGTCACTTGCTATTACATCTATTGAAATGGCAGAGGGGCGGCCA
CCCCTTTGTGAAATTCATCCAATGAGAGCCCTTTTTCTAATTAAAAGAAA
CCCCCCTCCAAAACTAAAATCTAGAAAATGGTCAACGAATTTTCATGATT
TTCTTGAAAAGGCACTTATCAAAAACTTCCACGAAGTAATAACTACTAAA
ATCAAGTTATGAATGATTTTAATTTCACTTATTTAAAATTTATTTTACAA
CTTTGGTAAACAAGAGTTGTAAATTGTTATTTCAATTGAAATAATAATCA
TTCCAGGTTTAATAGACTTGACCACAATTATGTACCGAAATATTTTTAAA
CATGATATTTCAATAATATTTCCTCCTTATTTTATATGGTTTTATTTATT
TATCGTTTCTTTTGGCATATATCTTTCAATAAAATATATGTATTTTGGAA
ATGTAGGTTGATTTCGTGTGATTGATAATGACAAATCTAAATAAAGGTTT
CCAAACAATTTCTTCAACATGATACAGTATTTTATCCGAGAAAGAAAATA
AGAATGAAATTCATCAAACATACTTAATATTTTGATAATTAATGAACTCA
AGTACATGTGTCATGTTCAAAAAATTTATCATTATTATTATCTGCAAAGT
CACAAAAATTTATCTCACAACTATTTGAAGTTGTTTTATTCTATTCATCA
AAACTTACTATAGTGGGTAATTTTCTTAAATAAATTTAGCAAGTAGTTAA
TCTAATAAGGATCAATTTTATTAACTTTCTCATCACGTTTTAAAGTGGAC
CAAAAATTTTCTTGGTATTATACTCATGGTTCCATAAATGAGGTTCCTAT
ATCTATTCTTACGGGAAAATGGACATGACAGTGTTTTGACATCTGATTTA
CCAATATTTCATTTTTTCAATTAAACGAATTGAAATTCTTTCATTTAATA
ATCATTGGATATGTGCTTCTGCATCTTTTTATCTTCCACATTAGTTATCT
TGTAGACTTGCTTGAAGCTCTCAATCAGCTGTAGCATCATAAAGTCATAA
CTATCATCATTGCTTTGCGAGTTGTCTGAGTTTATTCAAATTATTAAACA
ATATAATAAACCATTTATGGTGAGTGCAAATATCAAATAGTATAGAATCG
AATGCAAAACCAAAATCTGACGATCGATTAAAACTTCAAAATCGTAATTA
ATATGTTAATTAACTTGAGCAGACAAATGTTGTACTCACAATTATCATTC
AACAATGTATTAAATGGTACAACTAAGTAAATATATATAACAGTATTATA
TTAAAAAAATCCCATAAAAAATGAATCACATGTATCTACTTACTTTTATA
TTTTAAGTCTACTGCAATTATCCGTGATTTCATGATTTTGAAAATAAAAT
GTTTTAGAGACCCGTAACTGAACAACTTATCCAACATTCCTTTGTGAAAC
ATCTTCCAACAGAGCGCAAAGTAAGAATTGAAATTAAAGACCACATTGAT
CATTTCGGAAAGCATAAAAAAGTTATTCAACCTCCAATACCTCAGCAGAT
CAGTGATGATGAAGATGATGATATAAATGACGTCCTTCCTCTTCCGCCCC
CTCCTGAATCTCACCAAATTCTTCAAATGACAGATAAATTGCGTCAATTT
GAATTTCAAAATCAATTGCAAGTTTCAGTAGTAAATCAACCTGATATTTG
TACTTTAAAAAAGAATTTTGTTAAAATTCAAGAAAAAGATGGATTGAATT
TGAAAATGACAGAATCAAATCTTGTGAATCAGCTTCAGTTTATCAAATCA
GATGATAATTGTCCAATAAATAAATCCGATGAAAATCAGATTAAAGTTTC
TAAAAGTATATCTCCTGAGAAACTAAATAGGCATGTTAATAGTCCTAAAT
TAGAACCAAAAAATCATTCACCAAATATAAGAAAATTAACCGAAGCAAAT
TTTTCCCCTAAATTATCTAGTAATAATGTTCAACTGCAAACCAAATCTGT
TTCTCAAAAAAATAAATATGTTTCTAAACCTAAATTTCCTCCAACACGAC
CGACATCTACACAACTTTCTGAAAAATCGGAAGAACATCCTACGAATGTC
CAAAGATATAGTCAGATGGAATCGATGAATGTTGCAAAGATGAGTTTGAA
TAATCTATCAAATATTAAAGAAGTAGAAGATGCTAAAAAACTGGAATCTA
ATAATCAATGGCTTCAAGAACAAGAAAATGATTTGGGTAAAAATTCGGAC
AAAAAATGCAATGAAATAATGTTTCCAGAAGAAAAGAACATGGAATCAGA
TGATTCATTATCTGAGGATGAAATTAATACACTAGCTCCAGCCAAGAAAA
TACCCGTTTCTTCTTCAAAGAACAATGAAATTGCAGTAGTAATAAATGAA
AATAATTCTCAGGTTTGCATATTTATGTAATTAAATTTTATATTTCTTTG
TGCACATAACTTTGCTAGTCCATTGAAGTTCCATTATCGGCACTAGCTGG
AAATTCTGACGACGATGTTCTTTTGTGTAAGAAAAAATTTACTTGTGAAA
TATATTCCGCTACATTTTGGGGAAACAATTGTTTAGTTGGTTCTGAGTCA
GGTTTGGATTTTATTGATCGTACAGCACAATCTAAAGTTATACGTTTGGT
GAATAAAAGGAAGTTTGTACAAATAGATGTTTTAGAAGATATTGGAATAA
TGCTATCGATATCGGGAAAAAGACATCGTTTGAGAATGTATGCGCTGCAA
TGGTTGAAAAATAAAATAATGAAATCTGACACACAAGAAATAAAAGTTGG
ATGGGCAAATATTGGAGAAGACTTGGAGAATATACACCAATTTAAAACTG
TCTCATTTGAAAACATATTATTTTTGGTGATTTCTTTGAAAAATAGAATA
GATGTTTATGCGTGGGCTCCTCAACCTCAATGTAAATTCATGATTTATAA
AATATTGGATAATTTACCTGAAAAACCGCTACTTATAGAATTATCTATAG
TCCAAGAAAGTATTCCAACTGTACTTTATGCAACTACTCAAGGATTTTAC
GCAATTGATTTAACGTCTGATAGGCAATATAATTTATATATTCCTGAACA
TGTACCTACTCCAATACAACCTCATTGTATAGTTAAGGTTCCAAATAGTG
ATGGAATGTATCTACTGCTTTGTTATAACGTTGAAGGTGTTTATGTTGAT
GTTCGCGGTAATGTACTTAAAGATGTAGTTCTGCAATGGGGAGAAATTCC
AAATTCTGTAACACATACATCAAATAATCAAATTATAATATGGGGATGTA
AAGCTATTGAAATAAGAAAAGTTAATAATGGTCAAATAATGGGCATTTTT
ACCCACAAAAGAGATTATAAAACTAAATTTTTGTACGAAAAAAATGAAAA
GGTTTTATTTTCAACCGTACGATCAAGCACATCTCAAAATATTTCAATGA
TTAACTTAGTAGGCCGAAGTTGGTAGAATTAAACAAGATATGCTCAACCC
GTAATGAATATGTCTGACTAAAGAAAGTGCCAAAATTAACAGAAGCCTTA
CCACAGCAGTATCAACCGGAGTAGCTACAGGAAGCGTGCCAAATGAATCA
GAATTTATCAGCAACCAAGAAAGTAAAGCAATTAACGAACAAAACCATTC
AGAGTCAGAAAACGAAGCAAACAAGAGCGAAGAAGAGTATAAAAGACCAA
GACAACAATCTAGAAATGCCATCCGCAAACCAAGGCTTAGTATCAAATAA
TAATAACGCAGCTGTAGGAGAATTTAGAGAAAAATTTAGAGAATAGCCTT
TCGGTGGCAACCTCAAAAAACTGTTGGGCCAAGATACAAGTTTGTTTAAA
TGATTTAAAATCGGACCCATAAAAC
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protein sequence of SMED30023902-orf-1

>SMED30023902-orf-1 ID=SMED30023902-orf-1|Name=SMED30023902-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=268bp
MTDKLRQFEFQNQLQVSVVNQPDICTLKKNFVKIQEKDGLNLKMTESNLV
NQLQFIKSDDNCPINKSDENQIKVSKSISPEKLNRHVNSPKLEPKNHSPN
IRKLTEANFSPKLSSNNVQLQTKSVSQKNKYVSKPKFPPTRPTSTQLSEK
SEEHPTNVQRYSQMESMNVAKMSLNNLSNIKEVEDAKKLESNNQWLQEQE
NDLGKNSDKKCNEIMFPEEKNMESDDSLSEDEINTLAPAKKIPVSSSKNN
EIAVVINENNSQVCIFM*
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protein sequence of SMED30023902-orf-2

>SMED30023902-orf-2 ID=SMED30023902-orf-2|Name=SMED30023902-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=259bp
MLSISGKRHRLRMYALQWLKNKIMKSDTQEIKVGWANIGEDLENIHQFKT
VSFENILFLVISLKNRIDVYAWAPQPQCKFMIYKILDNLPEKPLLIELSI
VQESIPTVLYATTQGFYAIDLTSDRQYNLYIPEHVPTPIQPHCIVKVPNS
DGMYLLLCYNVEGVYVDVRGNVLKDVVLQWGEIPNSVTHTSNNQIIIWGC
KAIEIRKVNNGQIMGIFTHKRDYKTKFLYEKNEKVLFSTVRSSTSQNISM
INLVGRSW*
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protein sequence of SMED30023902-orf-3

>SMED30023902-orf-3 ID=SMED30023902-orf-3|Name=SMED30023902-orf-3|organism=Schmidtea mediterranea sexual|type=polypeptide|length=312bp
MSQRHFVNLRYCISICYLHKLCLILLKCILRYISINFFEMIKNLESLKDP
AGIFSLIEIVGKGTYGNVYKGQQIKTGLLAAIKVMEITQHEKEEIILEIN
TLRRLSDHPNVAAYYGAFVKHEAAADYLWLVMEFCGAGSITDLVRSTRYN
SLKEDWIAYISREILQGLSYLHANYVIHRDIKGQNVLLNDNAEVKLVDFG
VSAQLDRTFGKRNTFIGTPYWMAPEVIYCEENPNSTYDARSDLWSLAITS
IEMAEGRPPLCEIHPMRALFLIKRNPPPKLKSRKWSTNFHDFLEKALIKN
FHEVITTKIKL*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
Vocabulary: INTERPRO
TermDefinition
IPR000719Prot_kinase_dom
IPR008271Ser/Thr_kinase_AS
IPR017441Protein_kinase_ATP_BS
IPR011009Kinase-like_dom_sf
IPR001180CNH_dom
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0016310phosphorylation
Vocabulary: molecular function
TermDefinition
GO:0005524ATP binding
GO:0004672protein kinase activity
GO:0016301kinase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 54..310
e-value: 9.2E-76
score: 267.7
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 55..303
e-value: 2.3E-54
score: 184.5
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 54..311
score: 46.011
NoneNo IPR availableGENE3DG3DSA:3.30.200.20coord: 39..134
e-value: 3.9E-31
score: 109.2
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 135..310
e-value: 1.7E-55
score: 189.6
NoneNo IPR availablePIRSFPIRSF000654ILKcoord: 39..303
e-value: 5.3E-25
score: 85.6
NoneNo IPR availablePANTHERPTHR24361:SF225MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 4coord: 43..299
NoneNo IPR availablePANTHERPTHR24361MITOGEN-ACTIVATED KINASE KINASE KINASEcoord: 43..299
NoneNo IPR availableTMHMMTMhelixcoord: 13..35
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 176..188
IPR017441Protein kinase, ATP binding sitePROSITEPS00107PROTEIN_KINASE_ATPcoord: 60..83
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 54..306