Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

Overview
NameDeoxynucleoside triphosphate triphosphohydrolase SAMHD1
Smed IDSMED30023897
Length (bp)2128
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SMED30023897) t-SNE clustered cells

Violin plots show distribution of expression levels for Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SMED30023897) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SMED30023897) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SMED30023897) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30023897

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30023897SMESG000079585.1 SMESG000079583.1 dd_Smed_v4_17810_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30023897SMESG000079585.1 SMESG000079583.1 dd_Smed_v4_17810_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30023897SMESG000079585.1 SMESG000079583.1 dd_Smed_v4_17810_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30023897SMESG000079382.1 Contig51710newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30023897SMESG000079382.1 Contig51710uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
head regionSMED30023897SMESG000079585.1 SMESG000079583.1 dd_Smed_v6_17810_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
head regionSMED30023897SMESG000079585.1 SMESG000079583.1 dd_Smed_v6_25908_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Human
Match: SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925])

HSP 1 Score: 189.504 bits (480), Expect = 3.242e-51
Identity = 156/473 (32.98%), Postives = 241/473 (50.95%), Query Frame = 1 
Query:  538 IKKLMENEKVVT--KKMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRK--HEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTY------------NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIE-TVIGPKVYDPKIWFSSDFI---SKVCDYHIWNIMS------KYTSGIVEKIQERKLYKIF------DQIQIKLD-----PKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLV 1845
            +  L E +K+++  +++ +    T   +ND +HG I+L   +  IIDTPQFQRLR+I+QLG GY V+P A ++RFEHS+G  +LA  L+  L     K+    IS+ +V CV+IA LCHDLGHGPFSH+++  F        K  HE  SV +F  L+       +      I      I FI++ I+G               + E K F +EIV+NK +G+DVDK+DY  RD  +LG  N     D KR +   R+ +  +  +  +  RD+E+ +++D+F+ R+ LHR AYQHK   +I+ M   A    +K +D     IE T  G K Y  +I  + D +   +K+ D     I+       K    I+++I+ R L+K         QI+IK +     PK         L ++K K +DF +  +  +   G + K NP+  V+FY K  P+     T + +  L+
Sbjct:   91 VSSLGERKKLLSYIQRLVQIHVDTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGE---KQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED--ICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARVCEVDN--ELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAF---LKADD----YIEITGAGGKKY--RISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVI--NMDYGMQEK-NPIDHVSFYCKTAPNRAIRITKNQVSQLL 541
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Human
Match: SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925])

HSP 1 Score: 189.504 bits (480), Expect = 5.997e-51
Identity = 156/473 (32.98%), Postives = 241/473 (50.95%), Query Frame = 1 
Query:  538 IKKLMENEKVVT--KKMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRK--HEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTY------------NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIE-TVIGPKVYDPKIWFSSDFI---SKVCDYHIWNIMS------KYTSGIVEKIQERKLYKIF------DQIQIKLD-----PKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLV 1845
            +  L E +K+++  +++ +    T   +ND +HG I+L   +  IIDTPQFQRLR+I+QLG GY V+P A ++RFEHS+G  +LA  L+  L     K+    IS+ +V CV+IA LCHDLGHGPFSH+++  F        K  HE  SV +F  L+       +      I      I FI++ I+G               + E K F +EIV+NK +G+DVDK+DY  RD  +LG  N     D KR +   R+ +  +  +  +  RD+E+ +++D+F+ R+ LHR AYQHK   +I+ M   A    +K +D     IE T  G K Y  +I  + D +   +K+ D     I+       K    I+++I+ R L+K         QI+IK +     PK         L ++K K +DF +  +  +   G + K NP+  V+FY K  P+     T + +  L+
Sbjct:   91 VSSLGERKKLLSYIQRLVQIHVDTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGE---KQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED--ICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARVCEVDN--ELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAF---LKADD----YIEITGAGGKKY--RISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVI--NMDYGMQEK-NPIDHVSFYCKTAPNRAIRITKNQVSQLL 541
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Human
Match: SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925])

HSP 1 Score: 189.504 bits (480), Expect = 5.997e-51
Identity = 156/473 (32.98%), Postives = 241/473 (50.95%), Query Frame = 1 
Query:  538 IKKLMENEKVVT--KKMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRK--HEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTY------------NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIE-TVIGPKVYDPKIWFSSDFI---SKVCDYHIWNIMS------KYTSGIVEKIQERKLYKIF------DQIQIKLD-----PKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLV 1845
            +  L E +K+++  +++ +    T   +ND +HG I+L   +  IIDTPQFQRLR+I+QLG GY V+P A ++RFEHS+G  +LA  L+  L     K+    IS+ +V CV+IA LCHDLGHGPFSH+++  F        K  HE  SV +F  L+       +      I      I FI++ I+G               + E K F +EIV+NK +G+DVDK+DY  RD  +LG  N     D KR +   R+ +  +  +  +  RD+E+ +++D+F+ R+ LHR AYQHK   +I+ M   A    +K +D     IE T  G K Y  +I  + D +   +K+ D     I+       K    I+++I+ R L+K         QI+IK +     PK         L ++K K +DF +  +  +   G + K NP+  V+FY K  P+     T + +  L+
Sbjct:   91 VSSLGERKKLLSYIQRLVQIHVDTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGE---KQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED--ICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARVCEVDN--ELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAF---LKADD----YIEITGAGGKKY--RISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVI--NMDYGMQEK-NPIDHVSFYCKTAPNRAIRITKNQVSQLL 541
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Human
Match: SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925])

HSP 1 Score: 182.57 bits (462), Expect = 3.058e-50
Identity = 116/310 (37.42%), Postives = 176/310 (56.77%), Query Frame = 1 
Query:  538 IKKLMENEKVVT--KKMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRK--HEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTY------------NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAAL 1419
            +  L E +K+++  +++ +    T   +ND +HG I+L   +  IIDTPQFQRLR+I+QLG GY V+P A ++RFEHS+G  +LA  L+  L     K+    IS+ +V CV+IA LCHDLGHGPFSH+++  F        K  HE  SV +F  L+     G    +++   +  E I FI++ I+G               + E K F +EIV+NK +G+DVDK+DY  RD  +LG  N     D KR +   R+ +  +  +  +  RD+E+ +++D+F+ R+ LHR AYQHK   +I+ M   A 
Sbjct:   67 VSSLGERKKLLSYIQRLVQIHVDTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGE---KQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLI--NSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARVCEVDN--ELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAF 366
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Human
Match: SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925])

HSP 1 Score: 183.341 bits (464), Expect = 4.350e-49
Identity = 115/310 (37.10%), Postives = 172/310 (55.48%), Query Frame = 1 
Query:  538 IKKLMENEKVVT--KKMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRK--HEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTY------------NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAAL 1419
            +  L E +K+++  +++ +    T   +ND +HG I+L   +  IIDTPQFQRLR+I+QLG GY V+P A ++RFEHS+G  +LA  L+  L     K+    IS+ +V CV+IA LCHDLGHGPFSH+++  F        K  HE  SV +F  L+       +      I      I FI++ I+G               + E K F +EIV+NK +G+DVDK+DY  RD  +LG  N     D KR +   R+ +  +  +  +  RD+E+ +++D+F+ R+ LHR AYQHK   +I+ M   A 
Sbjct:   91 VSSLGERKKLLSYIQRLVQIHVDTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGE---KQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED--ICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARVCEVDN--ELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAF 390
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Celegans
Match: ZK177.8 (pep chromosome:WBcel235:II:5509032:5513775:-1 gene:WBGene00022673.1 transcript:ZK177.8b.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK177.8)

HSP 1 Score: 152.91 bits (385), Expect = 3.238e-39
Identity = 126/469 (26.87%), Postives = 214/469 (45.63%), Query Frame = 1 
Query:  613 VNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXX--XXXXXXXXXXMINFIEKLILGT--------------------YNKDE--------EKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAAL---NDIVKNEDARNELI--------------------ETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKY----------------TSGIVEKIQE--RKLYKIFDQIQIKLDPKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSE 1806
            +ND V+G +K+P  I ++IDT +FQRLRH++Q G  YLVYP   +SRF HS+GTF LA  L+ +L+   + +    I++ ++ C  +AAL HD+GHGPFSH+++  F  +     KHED+S+ I  +++   +        + E  +   + +  I +LI G                       K+E        EK F F++V+N  +G DVDK DYL RDS   G         ++R+ + +R+    ++G   +A   + I  +  +   R  LH   YQHK V+ +E +   AL    D +K + +  EL                     + ++  ++ DPK+  +   + K+    I   +  +                 +G  E +++  +K+ +I +Q+               D +E+  KLKD     + S    G ++K +P+    FY  + PSE
Sbjct:   12 INDNVYGTVKVPRPIDKLIDTVEFQRLRHLKQTGLVYLVYPNCEHSRFVHSLGTFSLAYALVDKLR---HSQPSLNITESDLICTSVAALLHDVGHGPFSHLFDGEFAKRNGSRFKHEDMSILIIKKIMNKPEIKSEFACILGETDEEYAKSVTLITELISGKPFDFQDMDGFKDLPADVREETVKNEWAIIGCGPEKSFLFDVVSNSYNGHDVDKMDYLLRDSKASGVGITFSESTLERLFNHVRVVIDPNSGLKRIAYSIKCIGDLKAIGDSRQELHSKVYQHKAVRFMETLMVDALINAGDFLKYKGSNGELYSLKNVTEDVDAFLKTTDYVEQEILNSQITDPKMIEAQTALLKIQRREIGCKLGYFEMNPENATQLKGNCNNQTGAAEVVKKVGQKMKEILEQMD--------------DTEEMDGKLKDIQFTVMHSVLGRGLDDKTHPIERQIFYDGK-PSE 462
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Celegans
Match: ZK177.8 (pep chromosome:WBcel235:II:5509028:5511208:-1 gene:WBGene00022673.1 transcript:ZK177.8b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK177.8)

HSP 1 Score: 152.91 bits (385), Expect = 3.238e-39
Identity = 126/469 (26.87%), Postives = 214/469 (45.63%), Query Frame = 1 
Query:  613 VNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXX--XXXXXXXXXXMINFIEKLILGT--------------------YNKDE--------EKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAAL---NDIVKNEDARNELI--------------------ETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKY----------------TSGIVEKIQE--RKLYKIFDQIQIKLDPKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSE 1806
            +ND V+G +K+P  I ++IDT +FQRLRH++Q G  YLVYP   +SRF HS+GTF LA  L+ +L+   + +    I++ ++ C  +AAL HD+GHGPFSH+++  F  +     KHED+S+ I  +++   +        + E  +   + +  I +LI G                       K+E        EK F F++V+N  +G DVDK DYL RDS   G         ++R+ + +R+    ++G   +A   + I  +  +   R  LH   YQHK V+ +E +   AL    D +K + +  EL                     + ++  ++ DPK+  +   + K+    I   +  +                 +G  E +++  +K+ +I +Q+               D +E+  KLKD     + S    G ++K +P+    FY  + PSE
Sbjct:   12 INDNVYGTVKVPRPIDKLIDTVEFQRLRHLKQTGLVYLVYPNCEHSRFVHSLGTFSLAYALVDKLR---HSQPSLNITESDLICTSVAALLHDVGHGPFSHLFDGEFAKRNGSRFKHEDMSILIIKKIMNKPEIKSEFACILGETDEEYAKSVTLITELISGKPFDFQDMDGFKDLPADVREETVKNEWAIIGCGPEKSFLFDVVSNSYNGHDVDKMDYLLRDSKASGVGITFSESTLERLFNHVRVVIDPNSGLKRIAYSIKCIGDLKAIGDSRQELHSKVYQHKAVRFMETLMVDALINAGDFLKYKGSNGELYSLKNVTEDVDAFLKTTDYVEQEILNSQITDPKMIEAQTALLKIQRREIGCKLGYFEMNPENATQLKGNCNNQTGAAEVVKKVGQKMKEILEQMD--------------DTEEMDGKLKDIQFTVMHSVLGRGLDDKTHPIERQIFYDGK-PSE 462
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Celegans
Match: ZK177.8 (pep chromosome:WBcel235:II:5509032:5513748:-1 gene:WBGene00022673.1 transcript:ZK177.8a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK177.8)

HSP 1 Score: 152.525 bits (384), Expect = 6.747e-39
Identity = 126/469 (26.87%), Postives = 214/469 (45.63%), Query Frame = 1 
Query:  613 VNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXX--XXXXXXXXXXMINFIEKLILGT--------------------YNKDE--------EKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAAL---NDIVKNEDARNELI--------------------ETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKY----------------TSGIVEKIQE--RKLYKIFDQIQIKLDPKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSE 1806
            +ND V+G +K+P  I ++IDT +FQRLRH++Q G  YLVYP   +SRF HS+GTF LA  L+ +L+   + +    I++ ++ C  +AAL HD+GHGPFSH+++  F  +     KHED+S+ I  +++   +        + E  +   + +  I +LI G                       K+E        EK F F++V+N  +G DVDK DYL RDS   G         ++R+ + +R+    ++G   +A   + I  +  +   R  LH   YQHK V+ +E +   AL    D +K + +  EL                     + ++  ++ DPK+  +   + K+    I   +  +                 +G  E +++  +K+ +I +Q+               D +E+  KLKD     + S    G ++K +P+    FY  + PSE
Sbjct:   46 INDNVYGTVKVPRPIDKLIDTVEFQRLRHLKQTGLVYLVYPNCEHSRFVHSLGTFSLAYALVDKLR---HSQPSLNITESDLICTSVAALLHDVGHGPFSHLFDGEFAKRNGSRFKHEDMSILIIKKIMNKPEIKSEFACILGETDEEYAKSVTLITELISGKPFDFQDMDGFKDLPADVREETVKNEWAIIGCGPEKSFLFDVVSNSYNGHDVDKMDYLLRDSKASGVGITFSESTLERLFNHVRVVIDPNSGLKRIAYSIKCIGDLKAIGDSRQELHSKVYQHKAVRFMETLMVDALINAGDFLKYKGSNGELYSLKNVTEDVDAFLKTTDYVEQEILNSQITDPKMIEAQTALLKIQRREIGCKLGYFEMNPENATQLKGNCNNQTGAAEVVKKVGQKMKEILEQMD--------------DTEEMDGKLKDIQFTVMHSVLGRGLDDKTHPIERQIFYDGK-PSE 496
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Fly
Match: fal (gene:FBgn0028380 transcript:FBtr0347258)

HSP 1 Score: 110.923 bits (276), Expect = 5.201e-26
Identity = 84/283 (29.68%), Postives = 141/283 (49.82%), Query Frame = 1 
Query:  610 FVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGF-GYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWE----HAFDSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYNKDEEKM----FFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIV 1431
             + D VHG+I+L  +I+EI++ P FQRL+H+ QLG   + +   A + R++H +G +  A + ++ ++   + E    + D   + VEIAAL HD+GHGP SH WE    H FD        HE+ ++    ++   K     + +  +       +  I+ LILG+       M    + F+IV N+  GLDVDK+DYL RD+  L   +  ++ D   +    RI+      ++  A   R    ++ +F  R LLH  AYQ+     ++ +F + +  I 
Sbjct:    2 LIEDEVHGVIELSSHIQEIVEHPLFQRLKHVHQLGLLPWAIDKKADHKRYDHCLGAYKSAQDHLRAIERNSHYEP--KLPDWCRQAVEIAALLHDIGHGPMSHAWELVTHHEFD--------HEENAMACVDKIF--KDALNQELVSLRDDGGGRGVQLIKALILGSSENLPFPMLGHTYIFDIVHNRRCGLDVDKWDYLRRDNKRLKILSSAEM-DFDDVFLQARISPDGQRIEYRYADYHR----VYRLFEARSLLHVKAYQYPLTCAMDVIFVSVVQRIA 267
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Fly
Match: fal (gene:FBgn0028380 transcript:FBtr0290284)

HSP 1 Score: 110.923 bits (276), Expect = 5.201e-26
Identity = 84/283 (29.68%), Postives = 141/283 (49.82%), Query Frame = 1 
Query:  610 FVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGF-GYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWE----HAFDSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYNKDEEKM----FFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIV 1431
             + D VHG+I+L  +I+EI++ P FQRL+H+ QLG   + +   A + R++H +G +  A + ++ ++   + E    + D   + VEIAAL HD+GHGP SH WE    H FD        HE+ ++    ++   K     + +  +       +  I+ LILG+       M    + F+IV N+  GLDVDK+DYL RD+  L   +  ++ D   +    RI+      ++  A   R    ++ +F  R LLH  AYQ+     ++ +F + +  I 
Sbjct:    2 LIEDEVHGVIELSSHIQEIVEHPLFQRLKHVHQLGLLPWAIDKKADHKRYDHCLGAYKSAQDHLRAIERNSHYEP--KLPDWCRQAVEIAALLHDIGHGPMSHAWELVTHHEFD--------HEENAMACVDKIF--KDALNQELVSLRDDGGGRGVQLIKALILGSSENLPFPMLGHTYIFDIVHNRRCGLDVDKWDYLRRDNKRLKILSSAEM-DFDDVFLQARISPDGQRIEYRYADYHR----VYRLFEARSLLHVKAYQYPLTCAMDVIFVSVVQRIA 267
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Fly
Match: fal (gene:FBgn0028380 transcript:FBtr0321324)

HSP 1 Score: 110.923 bits (276), Expect = 5.201e-26
Identity = 84/283 (29.68%), Postives = 141/283 (49.82%), Query Frame = 1 
Query:  610 FVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGF-GYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWE----HAFDSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYNKDEEKM----FFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIV 1431
             + D VHG+I+L  +I+EI++ P FQRL+H+ QLG   + +   A + R++H +G +  A + ++ ++   + E    + D   + VEIAAL HD+GHGP SH WE    H FD        HE+ ++    ++   K     + +  +       +  I+ LILG+       M    + F+IV N+  GLDVDK+DYL RD+  L   +  ++ D   +    RI+      ++  A   R    ++ +F  R LLH  AYQ+     ++ +F + +  I 
Sbjct:    2 LIEDEVHGVIELSSHIQEIVEHPLFQRLKHVHQLGLLPWAIDKKADHKRYDHCLGAYKSAQDHLRAIERNSHYEP--KLPDWCRQAVEIAALLHDIGHGPMSHAWELVTHHEFD--------HEENAMACVDKIF--KDALNQELVSLRDDGGGRGVQLIKALILGSSENLPFPMLGHTYIFDIVHNRRCGLDVDKWDYLRRDNKRLKILSSAEM-DFDDVFLQARISPDGQRIEYRYADYHR----VYRLFEARSLLHVKAYQYPLTCAMDVIFVSVVQRIA 267
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Zebrafish
Match: si:ch73-236c18.9 (si:ch73-236c18.9 [Source:ZFIN;Acc:ZDB-GENE-121214-125])

HSP 1 Score: 194.512 bits (493), Expect = 1.117e-53
Identity = 159/471 (33.76%), Postives = 231/471 (49.04%), Query Frame = 1 
Query:  616 NDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAF--DSQTIQPR-----------KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYNKDE---------EKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAA--LNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSGIVEKIQE------RKLYKIFDQIQIKLDPKFQGQNGHI----DLQEIKSKLK---------DFSIKSVCSSFSV-------GSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTI 1878
            ND +HG I L   + +I DTPQFQRLRH++QLG  YLVYP A ++RFEHSIG  +LA  L+K L     + K   I+  +  CV+IA LCHDLGHGP SHV++     +++ I+ R           KHE +SV +F  ++        + +  +  L    + FI++LI G    D          EK F +EIVANK +G+DVDK+DY  RD  +LG  N     D  R+L   R+   +  G+ H+  RD+E  +++D+F  R+ LHR AYQHK   +IE MF  A  L D   +ED   ++++               S+ I  V DY      SK T  I E+I        ++   I D+I  +  PKF G+         ++E+K+  K         D ++        V       G ++K NP+  V FYSK  P+E     D  L   +    NE ++ +
Sbjct:   64 NDPIHGHIALHPLLVKITDTPQFQRLRHLKQLGGTYLVYPGASHNRFEHSIGVAYLAGRLVKSLHDNQPELK---ITKQDFLCVQIAGLCHDLGHGPLSHVFDALVIPEAKKIKTRKGLPDDIPESWKHEQMSVLMFDSIV----KSLNEEVLREHGLTDNDVIFIKELIEGAKASDNEWPYKGRNVEKSFLYEIVANKQNGIDVDKWDYFARDCHHLGIRNS---FDHLRLLKFARVCVVN--GRKHICFRDKEADNVYDMFRTRYTLHRQAYQHKIGNIIEDMFAEALLLADRDLHEDRPADMLKI--------------SEAIKSVEDY------SKLTDEIFEQILSSTSPNLKESRDILDKIMRRKLPKFIGETRLTKKIKSMEELKNSWKAAIEKYKPTDPNVNLTTEELPVYVVDLDHGMKDK-NPIEHVYFYSKRKPNEASTIEDYQLSSFLPNKFNEELVRV 501
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Zebrafish
Match: si:ch73-236c18.8 (si:ch73-236c18.8 [Source:ZFIN;Acc:ZDB-GENE-121214-113])

HSP 1 Score: 193.741 bits (491), Expect = 2.343e-53
Identity = 152/461 (32.97%), Postives = 223/461 (48.37%), Query Frame = 1 
Query:  616 NDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWE-------------HAFDSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYNKDE---------EKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAAL----NDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMS------KYTSGIVEKIQERKLYKIFDQIQIKLDPKFQGQNGHIDLQEIKS-KLKDFSIKSVCSSFSV-------GSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTI 1878
            ND +HG I L   + +I DTPQFQRLRH++QLG  YLVYP A ++RFEHSIG  +LA  L+K L     + K   I+  +  CV+IA LCHDLGHGP SHV++                     +  KHE +SV +F  ++       ++            + FI++LI G    D          EK F +EIVANK +G+DVDK+DY  RD  +LG  N     D  R+L   R+   +  G+ H+  RD+E  +++D+F  R+ LHR AYQHK   +IE MF  AL     D+ + + A    I   I           S +  SK+ D     I+S      K +  I++KI  RKL K   ++++ +    + +  +     +K+ K  D ++        V       G ++K NP+  V FYSK  P+E     D  L   +    NE ++ +
Sbjct:   64 NDPIHGHIALHPLLVKITDTPQFQRLRHLKQLGGTYLVYPGASHNRFEHSIGVAYLAGRLVKSLHDNQPELK---ITKQDFLCVQIAGLCHDLGHGPLSHVFDVLVIPEVKKIKKLKGLPDDIPESWKHEQMSVLMFDSIVKSLNEEVLREHGLTDND----VIFIKELIEGAKASDNEWPYQGRNVEKSFLYEIVANKQNGIDVDKWDYFARDCHHLGIRNS---FDHLRLLKFARVCVVN--GRKHICFRDKEADNVYDMFRTRYTLHRQAYQHKIANIIEDMFAEALLLADRDLHEKKPADMLKISEAIK----------SVEDYSKLTDEIFEQILSSTSPNLKESKDILDKIMRRKLPKFIREVRLTVKNMSKEELKNSWKAAVKTYKPTDPTVTLTAEELPVYVVDLDHGMKDK-NPIERVYFYSKRKPNEASTIEDYQLSSFLPKKFNEELVRV 501
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Zebrafish
Match: samhd1 (SAM domain and HD domain 1 [Source:NCBI gene;Acc:553453])

HSP 1 Score: 192.971 bits (489), Expect = 1.732e-52
Identity = 148/459 (32.24%), Postives = 231/459 (50.33%), Query Frame = 1 
Query:  574 KKMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDM-ISDDEVKCVEIAALCHDLGHGPFSHVWEHAF--DSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTY-------------NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECM-----FKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSG--------IVEKIQERKLYKIFDQIQIKLDPKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSEN-------------------KGNPLLSVNFYSKENPSE 1806
            +K+++         ND +HG I+L   +   IDTPQFQRLRHI+QLG  YLV+P A ++RFEHSIG  +LA  L+K L    N+ + ++ I+  ++ CV+IA LCHDLGHGPFSH+++  F   ++     KHE  SV++F  L+  +  G    +        E + FI++ I G                +  EK F +E+VANK +G+DVDK+DY  RD  +LG  N     D +R L   R+ +    G+ H+  RD+E+ +++D+F+ R+ LHR AYQHK   +IE M      KA  +  ++    R   I + I             +  SK+ D+    I+  Y+SG        I++ I  R+LYK   Q   + +         +D+ +   KL D++ K +  S   G+E                    + NP+ +V+FY K +P++
Sbjct:   84 QKLSQISTEPMKVFNDPIHGHIELHPLLLHFIDTPQFQRLRHIKQLGGTYLVFPGASHNRFEHSIGVGYLAGCLVKAL----NERQPELFITKQDILCVQIAGLCHDLGHGPFSHMFDGMFIPKARPADKWKHEIASVQMFDHLV--EVNGLEAVMLHHGMRLPEDLIFIKEQIAGPLESAVLDQSQWPYKGRPVEKSFLYEVVANKRNGIDVDKWDYFARDCYHLGIQNN---FDYQRFLRFARVCEVK--GRKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIETMITEAFLKADPHIQIQGSSGRIFTISSAIE----------DMEAYSKLTDHIFEQIL--YSSGPELSEARAILQNIICRRLYKCVGQTTSETN---------VDVSQ--EKLLDWA-KELARSKPTGTEGNLIAEDFVVSVIHMDYGMKEKNPINNVHFYCKNDPTK 507
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Xenopus
Match: SAMHD1 (SAM domain and HD domain 1 [Source:NCBI gene;Acc:100498574])

HSP 1 Score: 198.749 bits (504), Expect = 8.060e-55
Identity = 147/446 (32.96%), Postives = 226/446 (50.67%), Query Frame = 1 
Query:  607 SFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR--KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYNKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECM-----FKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIW---NIMSKYTSGIVEKIQERKLYKIFDQIQIKLDPKFQGQN------------GHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTI 1878
            S  ND +HG I+L   +  IIDTP+FQRLR+I+QLG  Y V+P A ++RFEHSIG  +LA  L++ L     ++    I+  ++ CV+IA LCHDLGHGPFSH+++  F       R  KHE  SV +F  L+  K  G  + +KE      + + FI++ I     + EEK F +EIVANK +G+DVDK+DY  RD  +LG  N     D KR L   R+ +     K H+  RD+E+ +++D+F+ R+ LHR AYQHK   +IE M      KA  +  +K  D     I   +   V   K+   +D I     +HI    N   K    I+ K++ R+LYK   Q    ++ + +                     +++   +DF +  +   + +  +   NP+ +V FY K +P +      D +  L+     E ++ +
Sbjct:   50 SVFNDPIHGHIELHPLLVRIIDTPEFQRLRYIKQLGGSYYVFPGASHNRFEHSIGVGYLAGCLVQALHE---RQPELQINHRDMLCVQIAGLCHDLGHGPFSHMFDGRFMPLACPKRKFKHESASVAMFDHLI--KSNGLEEVMKEYGLCLPDDLTFIKEQIWPYRGRTEEKSFLYEIVANKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFLKFARVCEVG--SKKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIETMITDAFIKADPHIRIKGSDGNYYTISGSVDDMVAYTKL---TDNIY----HHILYSDNPDLKEAREILRKVERRQLYKFVGQTHPSINSRIEPDEYDTLPADLAKSVPQTSTTDVELNTEDFIVDVIHMDYGMKEQ---NPINNVRFYCKSDPRKAIKIRRDQVSQLLPEKFAEQIIRV 475
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Xenopus
Match: SAMHD1 (SAM domain and HD domain 1 [Source:NCBI gene;Acc:100498574])

HSP 1 Score: 197.978 bits (502), Expect = 4.061e-54
Identity = 146/443 (32.96%), Postives = 225/443 (50.79%), Query Frame = 1 
Query:  616 NDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR--KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYNKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECM-----FKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIW---NIMSKYTSGIVEKIQERKLYKIFDQIQIKLDPKFQGQN------------GHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTI 1878
            ND +HG I+L   +  IIDTP+FQRLR+I+QLG  Y V+P A ++RFEHSIG  +LA  L++ L     ++    I+  ++ CV+IA LCHDLGHGPFSH+++  F       R  KHE  SV +F  L+  K  G  + +KE      + + FI++ I     + EEK F +EIVANK +G+DVDK+DY  RD  +LG  N     D KR L   R+ +     K H+  RD+E+ +++D+F+ R+ LHR AYQHK   +IE M      KA  +  +K  D     I   +   V   K+   +D I     +HI    N   K    I+ K++ R+LYK   Q    ++ + +                     +++   +DF +  +   + +  +   NP+ +V FY K +P +      D +  L+     E ++ +
Sbjct:  112 NDPIHGHIELHPLLVRIIDTPEFQRLRYIKQLGGSYYVFPGASHNRFEHSIGVGYLAGCLVQALHE---RQPELQINHRDMLCVQIAGLCHDLGHGPFSHMFDGRFMPLACPKRKFKHESASVAMFDHLI--KSNGLEEVMKEYGLCLPDDLTFIKEQIWPYRGRTEEKSFLYEIVANKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFLKFARVCEVG--SKKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIETMITDAFIKADPHIRIKGSDGNYYTISGSVDDMVAYTKL---TDNIY----HHILYSDNPDLKEAREILRKVERRQLYKFVGQTHPSINSRIEPDEYDTLPADLAKSVPQTSTTDVELNTEDFIVDVIHMDYGMKEQ---NPINNVRFYCKSDPRKAIKIRRDQVSQLLPEKFAEQIIRV 534
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Xenopus
Match: SAMHD1 (SAM domain and HD domain 1 [Source:NCBI gene;Acc:100498574])

HSP 1 Score: 195.282 bits (495), Expect = 6.229e-54
Identity = 149/460 (32.39%), Postives = 230/460 (50.00%), Query Frame = 1 
Query:  616 NDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR--KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYN--------------------KDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECM-----FKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIW---NIMSKYTSGIVEKIQERKLYKIFDQIQIKLDPKFQGQNGHIDLQ---------EIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTI 1878
            ND +HG I+L   +  IIDTP+FQRLR+I+QLG  Y V+P A ++RFEHSIG  +LA  L++ L     ++    I+  ++ CV+IA LCHDLGHGPFSH+++  F       R  KHE  SV +F  L+  K  G  + +KE      + + FI++ I G  +                    + EEK F +EIVANK +G+DVDK+DY  RD  +LG  N     D KR L   R+ +     K H+  RD+E+ +++D+F+ R+ LHR AYQHK   +IE M      KA  +  +K  D     I   +   V   K+   +D I     +HI    N   K    I+ K++ R+LYK   Q    ++ + +    + DL          +++   +DF +  +   + +  +   NP+ +V FY K +P +      D +  L+     E ++ +
Sbjct:    5 NDPIHGHIELHPLLVRIIDTPEFQRLRYIKQLGGSYYVFPGASHNRFEHSIGVGYLAGCLVQALHE---RQPELQINHRDMLCVQIAGLCHDLGHGPFSHMFDGRFMPLACPKRKFKHESASVAMFDHLI--KSNGLEEVMKEYGLCLPDDLTFIKEQIAGPLSSEDEQQFNSSQNSSSWPYRGRTEEKSFLYEIVANKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFLKFARVCEVG--SKKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIETMITDAFIKADPHIRIKGSDGNYYTISGSVDDMVAYTKL---TDNIY----HHILYSDNPDLKEAREILRKVERRQLYKFVGQTHPSINSRIEPVRINTDLAKSVPQTSTTDVELNTEDFIVDVIHMDYGMKEQ---NPINNVRFYCKSDPRKAIKIRRDQVSQLLPEKFAEQIIRV 444
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Xenopus
Match: SAMHD1 (SAM domain and HD domain 1 [Source:NCBI gene;Acc:100498574])

HSP 1 Score: 192.971 bits (489), Expect = 1.899e-53
Identity = 147/458 (32.10%), Postives = 227/458 (49.56%), Query Frame = 1 
Query:  616 NDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR--KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGT---------------YNKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECM-----FKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIW---NIMSKYTSGIVEKIQERKLYKIFDQIQIKLDPKFQGQN------------GHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTI 1878
            ND +HG I+L   +  IIDTP+FQRLR+I+QLG  Y V+P A ++RFEHSIG  +LA  L++ L     ++    I+  ++ CV+IA LCHDLGHGPFSH+++  F       R  KHE  SV +F  L+  K  G  + +KE      + + FI++ I G                + + EEK F +EIVANK +G+DVDK+DY  RD  +LG  N     D KR L   R+ +     K H+  RD+E+ +++D+F+ R+ LHR AYQHK   +IE M      KA  +  +K  D     I   +   V   K+   +D I     +HI    N   K    I+ K++ R+LYK   Q    ++ + +                     +++   +DF +  +   + +  +   NP+ +V FY K +P +      D +  L+     E ++ +
Sbjct:    5 NDPIHGHIELHPLLVRIIDTPEFQRLRYIKQLGGSYYVFPGASHNRFEHSIGVGYLAGCLVQALHE---RQPELQINHRDMLCVQIAGLCHDLGHGPFSHMFDGRFMPLACPKRKFKHESASVAMFDHLI--KSNGLEEVMKEYGLCLPDDLTFIKEQIAGPLSSEDDAASFSTWYIFCRTEEKSFLYEIVANKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFLKFARVCEVG--SKKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIETMITDAFIKADPHIRIKGSDGNYYTISGSVDDMVAYTKL---TDNIY----HHILYSDNPDLKEAREILRKVERRQLYKFVGQTHPSINSRIEPDEYDTLPADLAKSVPQTSTTDVELNTEDFIVDVIHMDYGMKEQ---NPINNVRFYCKSDPRKAIKIRRDQVSQLLPEKFAEQIIRV 442
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Xenopus
Match: SAMHD1 (SAM domain and HD domain 1 [Source:NCBI gene;Acc:100498574])

HSP 1 Score: 194.126 bits (492), Expect = 2.510e-53
Identity = 147/453 (32.45%), Postives = 227/453 (50.11%), Query Frame = 1 
Query:  616 NDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR--KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTY----------NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECM-----FKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIW---NIMSKYTSGIVEKIQERKLYKIFDQIQIKLDPKFQGQN------------GHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTI 1878
            ND +HG I+L   +  IIDTP+FQRLR+I+QLG  Y V+P A ++RFEHSIG  +LA  L++ L     ++    I+  ++ CV+IA LCHDLGHGPFSH+++  F       R  KHE  SV +F  L+  K  G  + +KE      + + FI++ I G            ++ EEK F +EIVANK +G+DVDK+DY  RD  +LG  N     D KR L   R+ +     K H+  RD+E+ +++D+F+ R+ LHR AYQHK   +IE M      KA  +  +K  D     I   +   V   K+   +D I     +HI    N   K    I+ K++ R+LYK   Q    ++ + +                     +++   +DF +  +   + +  +   NP+ +V FY K +P +      D +  L+     E ++ +
Sbjct:   30 NDPIHGHIELHPLLVRIIDTPEFQRLRYIKQLGGSYYVFPGASHNRFEHSIGVGYLAGCLVQALHE---RQPELQINHRDMLCVQIAGLCHDLGHGPFSHMFDGRFMPLACPKRKFKHESASVAMFDHLI--KSNGLEEVMKEYGLCLPDDLTFIKEQIAGPLSSEDEQQFNSSRTEEKSFLYEIVANKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFLKFARVCEVG--SKKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIETMITDAFIKADPHIRIKGSDGNYYTISGSVDDMVAYTKL---TDNIY----HHILYSDNPDLKEAREILRKVERRQLYKFVGQTHPSINSRIEPDEYDTLPADLAKSVPQTSTTDVELNTEDFIVDVIHMDYGMKEQ---NPINNVRFYCKSDPRKAIKIRRDQVSQLLPEKFAEQIIRV 462
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Mouse
Match: Samhd1 (SAM domain and HD domain, 1 [Source:MGI Symbol;Acc:MGI:1927468])

HSP 1 Score: 187.963 bits (476), Expect = 6.861e-51
Identity = 144/461 (31.24%), Postives = 228/461 (49.46%), Query Frame = 1 
Query:  538 IKKLMENEKVVT--KKMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR--KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGT------------YNKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAK-----KSDTGKW----HLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCD------YHIWNIMSKYTSGIVEKIQERKLYKIFDQIQIKLD----------PKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKEN 1797
            +  L E +K++   ++++++R       ND +HG I+    +  IIDTPQFQRLR+I+QLG GY V+P A ++RFEHS+G  +LA  L++ L     K+    IS+ ++ CV+IA LCHDLGHGPFSH+++  F  +    +  KHE  S+E+F  L+   +   +      +      I FI++ I+G               +   K F +EIV+NK +G+DVDK+DY  RD  +LG  N     D KR +   RI +     K D        H+  R++E+ +++D+F+ R+ LHR AYQHK   +I+ M    + D     D   E+  T  G K          +  +K+ D       H  +        I+  I+ R LYK   + Q K +          P+   +       +++ K +DF +  +  +   G E+K NP+  V+FY K N
Sbjct:  123 VSSLEERKKMIECIQQLSQSRIDLMKVFNDPIHGHIEFHPLLIRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVRALAE---KQPELQISERDILCVQIAGLCHDLGHGPFSHMFDGRFIPRARPEKKWKHEQGSIEMFEHLVNSNELKLVMKNYGLVPEED--ITFIKEQIMGPPITPVKDSLWPYKGRPATKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARICEVEYKVKEDKTYIRKVKHICSREKEVGNLYDMFHTRNCLHRRAYQHKISNLIDIM----ITDAFLKADPYVEITGTA-GKKFRISTAIDDMEAFTKLTDNIFLEVLHSTDPQLSEAQSILRNIECRNLYKYLGETQPKREKIRKEEYERLPQEVAKAKPEKAPDVELKAEDFIVDVI--NVDYGMEDK-NPIDRVHFYCKSN 567
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Mouse
Match: Samhd1 (SAM domain and HD domain, 1 [Source:MGI Symbol;Acc:MGI:1927468])

HSP 1 Score: 188.348 bits (477), Expect = 1.484e-50
Identity = 145/477 (30.40%), Postives = 233/477 (48.85%), Query Frame = 1 
Query:  538 IKKLMENEKVVT--KKMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR--KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTY------------NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAK-----KSDTGKW----HLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCD------YHIWNIMSKYTSGIVEKIQERKLYKIFDQIQIKLD----------PKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLV 1845
            +  L E +K++   ++++++R       ND +HG I+    +  IIDTPQFQRLR+I+QLG GY V+P A ++RFEHS+G  +LA  L++ L     K+    IS+ ++ CV+IA LCHDLGHGPFSH+++  F  +    +  KHE  S+E+F  L+   +   +      +      I FI++ I+G               +   K F +EIV+NK +G+DVDK+DY  RD  +LG  N     D KR +   RI +     K D        H+  R++E+ +++D+F+ R+ LHR AYQHK   +I+ M    + D     D   E+  T  G K          +  +K+ D       H  +        I+  I+ R LYK   + Q K +          P+   +       +++ K +DF +  +  +   G E+K NP+  V+FY K N  +      + +  L+
Sbjct:  123 VSSLEERKKMIECIQQLSQSRIDLMKVFNDPIHGHIEFHPLLIRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVRAL---AEKQPELQISERDILCVQIAGLCHDLGHGPFSHMFDGRFIPRARPEKKWKHEQGSIEMFEHLVNSNELKLVMKNYGLVPEED--ITFIKEQIMGPPITPVKDSLWPYKGRPATKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARICEVEYKVKEDKTYIRKVKHICSREKEVGNLYDMFHTRNCLHRRAYQHKISNLIDIM----ITDAFLKADPYVEITGTA-GKKFRISTAIDDMEAFTKLTDNIFLEVLHSTDPQLSEAQSILRNIECRNLYKYLGETQPKREKIRKEEYERLPQEVAKAKPEKAPDVELKAEDFIVDVI--NVDYGMEDK-NPIDRVHFYCKSNSKQAVRINKEQVSQLL 583
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Mouse
Match: Samhd1 (SAM domain and HD domain, 1 [Source:MGI Symbol;Acc:MGI:1927468])

HSP 1 Score: 187.963 bits (476), Expect = 1.518e-50
Identity = 145/477 (30.40%), Postives = 233/477 (48.85%), Query Frame = 1 
Query:  538 IKKLMENEKVVT--KKMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR--KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGT------------YNKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAK-----KSDTGKW----HLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCD------YHIWNIMSKYTSGIVEKIQERKLYKIFDQIQIKLD----------PKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLV 1845
            +  L E +K++   ++++++R       ND +HG I+    +  IIDTPQFQRLR+I+QLG GY V+P A ++RFEHS+G  +LA  L++ L     K+    IS+ ++ CV+IA LCHDLGHGPFSH+++  F  +    +  KHE  S+E+F  L+   +   +      +      I FI++ I+G               +   K F +EIV+NK +G+DVDK+DY  RD  +LG  N     D KR +   RI +     K D        H+  R++E+ +++D+F+ R+ LHR AYQHK   +I+ M    + D     D   E+  T  G K          +  +K+ D       H  +        I+  I+ R LYK   + Q K +          P+   +       +++ K +DF +  +  +   G E+K NP+  V+FY K N  +      + +  L+
Sbjct:  103 VSSLEERKKMIECIQQLSQSRIDLMKVFNDPIHGHIEFHPLLIRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVRAL---AEKQPELQISERDILCVQIAGLCHDLGHGPFSHMFDGRFIPRARPEKKWKHEQGSIEMFEHLVNSNELKLVMKNYGLVPEED--ITFIKEQIMGPPITPVKDSLWPYKGRPATKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARICEVEYKVKEDKTYIRKVKHICSREKEVGNLYDMFHTRNCLHRRAYQHKISNLIDIM----ITDAFLKADPYVEITGTA-GKKFRISTAIDDMEAFTKLTDNIFLEVLHSTDPQLSEAQSILRNIECRNLYKYLGETQPKREKIRKEEYERLPQEVAKAKPEKAPDVELKAEDFIVDVI--NVDYGMEDK-NPIDRVHFYCKSNSKQAVRINKEQVSQLL 563
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Mouse
Match: Samhd1 (SAM domain and HD domain, 1 [Source:MGI Symbol;Acc:MGI:1927468])

HSP 1 Score: 187.963 bits (476), Expect = 1.746e-50
Identity = 145/477 (30.40%), Postives = 233/477 (48.85%), Query Frame = 1 
Query:  538 IKKLMENEKVVT--KKMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR--KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGT------------YNKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAK-----KSDTGKW----HLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCD------YHIWNIMSKYTSGIVEKIQERKLYKIFDQIQIKLD----------PKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLV 1845
            +  L E +K++   ++++++R       ND +HG I+    +  IIDTPQFQRLR+I+QLG GY V+P A ++RFEHS+G  +LA  L++ L     K+    IS+ ++ CV+IA LCHDLGHGPFSH+++  F  +    +  KHE  S+E+F  L+   +   +      +      I FI++ I+G               +   K F +EIV+NK +G+DVDK+DY  RD  +LG  N     D KR +   RI +     K D        H+  R++E+ +++D+F+ R+ LHR AYQHK   +I+ M    + D     D   E+  T  G K          +  +K+ D       H  +        I+  I+ R LYK   + Q K +          P+   +       +++ K +DF +  +  +   G E+K NP+  V+FY K N  +      + +  L+
Sbjct:  123 VSSLEERKKMIECIQQLSQSRIDLMKVFNDPIHGHIEFHPLLIRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVRALAE---KQPELQISERDILCVQIAGLCHDLGHGPFSHMFDGRFIPRARPEKKWKHEQGSIEMFEHLVNSNELKLVMKNYGLVPEED--ITFIKEQIMGPPITPVKDSLWPYKGRPATKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARICEVEYKVKEDKTYIRKVKHICSREKEVGNLYDMFHTRNCLHRRAYQHKISNLIDIM----ITDAFLKADPYVEITGTA-GKKFRISTAIDDMEAFTKLTDNIFLEVLHSTDPQLSEAQSILRNIECRNLYKYLGETQPKREKIRKEEYERLPQEVAKAKPEKAPDVELKAEDFIVDVI--NVDYGMEDK-NPIDRVHFYCKSNSKQAVRINKEQVSQLL 583
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. UniProt/SwissProt
Match: sp|Q5ZJL9|SAMH1_CHICK (Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Gallus gallus OX=9031 GN=SAMHD1 PE=2 SV=2)

HSP 1 Score: 202.601 bits (514), Expect = 4.250e-55
Identity = 150/464 (32.33%), Postives = 239/464 (51.51%), Query Frame = 1 
Query:  580 MTEARNSTD--SFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR--KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYN------------KDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALND---IVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSGIVEKIQERKLYKIFDQIQ---IKLDPK--FQGQNGHI-------DLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTI 1878
            + + R + D     ND VHG I++   +  IIDTPQFQRLR+I+QLG  Y V+P A ++RFEHS+G  +LA  L+++LK +  + ++D+   D + CVEIA LCHDLGHGPFSH+++  F     Q    KHE  SVE+F  L+   K  EI      I      I FI++ I G  +            + +EK F +EIVANK +G+DVDK+DY  RD  +LG  N     D +R++   R+ +  +  + H+  RD+E+ +++D+F+ R+ LHR AYQHK   +IE M   A        + E ++ +L       +  +     + +   ++   H           I+ KI+ R+LYK   + Q   +   PK  + G  G I       D  +++   +DF +  V   + +  +   NP+ +V FY K +PS+    + + +  L+    +E V+ +
Sbjct:   96 LNQLRQTADIMKVFNDPVHGHIEIHPLLVRIIDTPQFQRLRYIKQLGGTYFVFPGASHNRFEHSLGVGYLAGCLVRELKER--QPELDITQRD-ILCVEIAGLCHDLGHGPFSHMFDGRFIPLARQGLNWKHETASVEMFEHLITSNKLEEIMESYGLILEED--IAFIKEQIGGPIDETACEESWPYRGRPKEKSFLYEIVANKKNGIDVDKWDYFARDCHHLGIQNN---FDYRRLIKFTRVCEAGN--QKHICARDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIEIMITEAFQKADCFFQIEGSKGKLYHISTAMEDMEAYTKLTDNIYLEI--LHSSRPELSEAREILHKIERRELYKFLGETQPEKVNEIPKDEYDGLAGDIANSKPEKDPPDVELTAEDFIVDVVNMDYGMKDQ---NPIDNVLFYCKADPSKAIKISKEQVSRLLPGTFSEQVIRV 544
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. UniProt/SwissProt
Match: sp|Q502K2|SAMH1_DANRE (Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Danio rerio OX=7955 GN=samhd1 PE=2 SV=2)

HSP 1 Score: 192.971 bits (489), Expect = 1.347e-51
Identity = 148/459 (32.24%), Postives = 231/459 (50.33%), Query Frame = 1 
Query:  574 KKMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDM-ISDDEVKCVEIAALCHDLGHGPFSHVWEHAF--DSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTY-------------NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECM-----FKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSG--------IVEKIQERKLYKIFDQIQIKLDPKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSEN-------------------KGNPLLSVNFYSKENPSE 1806
            +K+++         ND +HG I+L   +   IDTPQFQRLRHI+QLG  YLV+P A ++RFEHSIG  +LA  L+K L    N+ + ++ I+  ++ CV+IA LCHDLGHGPFSH+++  F   ++     KHE  SV++F  L+  +  G    +        E + FI++ I G                +  EK F +E+VANK +G+DVDK+DY  RD  +LG  N     D +R L   R+ +    G+ H+  RD+E+ +++D+F+ R+ LHR AYQHK   +IE M      KA  +  ++    R   I + I             +  SK+ D+    I+  Y+SG        I++ I  R+LYK   Q   + +         +D+ +   KL D++ K +  S   G+E                    + NP+ +V+FY K +P++
Sbjct:   84 QKLSQISTEPMKVFNDPIHGHIELHPLLLHFIDTPQFQRLRHIKQLGGTYLVFPGASHNRFEHSIGVGYLAGCLVKAL----NERQPELFITKQDILCVQIAGLCHDLGHGPFSHMFDGMFIPKARPADKWKHEIASVQMFDHLV--EVNGLEAVMLHHGMRLPEDLIFIKEQIAGPLESAVLDQSQWPYKGRPVEKSFLYEVVANKRNGIDVDKWDYFARDCYHLGIQNN---FDYQRFLRFARVCEVK--GRKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIETMITEAFLKADPHIQIQGSSGRIFTISSAIE----------DMEAYSKLTDHIFEQIL--YSSGPELSEARAILQNIICRRLYKCVGQTTSETN---------VDVSQ--EKLLDWA-KELARSKPTGTEGNLIAEDFVVSVIHMDYGMKEKNPINNVHFYCKNDPTK 507
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. UniProt/SwissProt
Match: sp|Q6INN8|SAMH1_XENLA (Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Xenopus laevis OX=8355 GN=samhd1 PE=1 SV=2)

HSP 1 Score: 190.274 bits (482), Expect = 1.291e-50
Identity = 149/491 (30.35%), Postives = 232/491 (47.25%), Query Frame = 1 
Query:  493 DFVIISLII-LDFRKKIKKLMENEKVVTKKMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR--KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYN--------------------KDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAAL---NDIVKNEDARNELIETVIGPKVYDPKIW--FSSDFISKVCDYHIWNIMSKYTSGIVEKIQERKLYKIFDQIQI------------KLDPKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLV 1845
            D  I S+ + LD    ++ L +N   + K             ND +HG I+L   +  IIDTP+FQRLR+I+QLG  Y V+P A ++RFEHSIG  +LA  L++ L  +    ++DM    ++ CV+IA LCHDLGHGPFSH+++  F       +  KHE  SV +F  L+      E          +   + FI++ I G  +                    + EEK F +EIVANK +G+DVDK+DY  RD  +LG  N     D KR L   R+ +     K H+  RD+E+ +++D+F+ R+ LHR AYQHK   +IE M   A    +  +K E A  +     I   V D   +   + +   ++   +  N+  K    I++K++ R LYK   Q               KL             ++++   +DF +  +   + +  +   NP+ +V FY K +P +      D +  L+
Sbjct:   85 DLQISSVALRLDLLSCLRMLCQNSPSIMK-----------VFNDPIHGHIELHPLLVRIIDTPEFQRLRYIKQLGGSYYVFPGASHNRFEHSIGVGYLAGCLVQALHERQPDLQIDM---RDMLCVQIAGLCHDLGHGPFSHMFDGRFMPLACPQKKFKHESASVAMFDHLIQSNGLEEAMKENGLCLPDD--LTFIKEQIAGPLSSEAEQQFNSSPNSSSWPYRGRTEEKSFLYEIVANKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFLKFARVCEVG--SKKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVGNIIETMITDAFVKADPHIKIEGANGKYYS--ISGSVDDMVAYTKLTDNIYHQILYSNDPNL--KEAREILQKVERRHLYKYIGQTHPHSNSRIEPDKYDKLPADLASSVPQTSAKDVELHAEDFIVDVIHMDYGMKEQ---NPINNVRFYCKADPRKAIKIRRDQVSQLL 547
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. UniProt/SwissProt
Match: sp|Q9Y3Z3|SAMH1_HUMAN (Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Homo sapiens OX=9606 GN=SAMHD1 PE=1 SV=2)

HSP 1 Score: 189.504 bits (480), Expect = 2.880e-50
Identity = 156/473 (32.98%), Postives = 241/473 (50.95%), Query Frame = 1 
Query:  538 IKKLMENEKVVT--KKMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRK--HEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTY------------NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIE-TVIGPKVYDPKIWFSSDFI---SKVCDYHIWNIMS------KYTSGIVEKIQERKLYKIF------DQIQIKLD-----PKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLV 1845
            +  L E +K+++  +++ +    T   +ND +HG I+L   +  IIDTPQFQRLR+I+QLG GY V+P A ++RFEHS+G  +LA  L+  L     K+    IS+ +V CV+IA LCHDLGHGPFSH+++  F        K  HE  SV +F  L+       +      I      I FI++ I+G               + E K F +EIV+NK +G+DVDK+DY  RD  +LG  N     D KR +   R+ +  +  +  +  RD+E+ +++D+F+ R+ LHR AYQHK   +I+ M   A    +K +D     IE T  G K Y  +I  + D +   +K+ D     I+       K    I+++I+ R L+K         QI+IK +     PK         L ++K K +DF +  +  +   G + K NP+  V+FY K  P+     T + +  L+
Sbjct:   91 VSSLGERKKLLSYIQRLVQIHVDTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGE---KQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED--ICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNN---FDYKRFIKFARVCEVDN--ELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAF---LKADD----YIEITGAGGKKY--RISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVI--NMDYGMQEK-NPIDHVSFYCKTAPNRAIRITKNQVSQLL 541
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. UniProt/SwissProt
Match: sp|Q0VCA5|SAMH1_BOVIN (Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Bos taurus OX=9913 GN=SAMHD1 PE=2 SV=1)

HSP 1 Score: 187.193 bits (474), Expect = 9.418e-50
Identity = 143/465 (30.75%), Postives = 226/465 (48.60%), Query Frame = 1 
Query:  577 KMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR---KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTY-------------NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSG------IVEKIQERKLYKIFDQIQIKLDPKFQGQNGHIDLQEIKSKLKDFSIKSVCSS---------FSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTI 1878
            K+      T   +ND +HG I+    +  IIDTPQFQRLR+I+QLG GY V+P A ++RFEHS+G  +LA  L+++L     K+    IS+ ++ CV+IA LCHDLGHGPFSH+++  F     +P     HE  SV +F  L+      ++      I     +  FI++ I G                + +EK F +EIVANK +G+DVDK+DY  RD  +LG  N     D KR L   R+ +  +    H+  R++E+ +++D+F+ R+ LHR AYQHK   +I+ M   A    +K +D     I    G K +        +  +K+ D     I+            I++KI+ R LYK   + Q  +    +    H+  +   +K  D  +++   +            G E+K NP+  V FY K + S+    T + +   +     E ++ +
Sbjct:   94 KLLNCIQDTMKVINDPIHGHIEFHPLLMRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGRLVRELSE---KQPELQISERDILCVQIAGLCHDLGHGPFSHMFDGRF-IPLARPEIKWTHEQGSVMMFEHLINSNGLQDVMKYYGLIPEEDIL--FIKEQITGPPESPIKDASKWLYKGRPKEKSFLYEIVANKRNGIDVDKWDYFARDCHHLGIQNS---FDYKRFLKFARVCEVDNMK--HICTREKEVGNLYDMFHTRNCLHRRAYQHKVGNIIDTMITDAF---LKADDHIE--ITGSAGRKYHISTAIDDMEAFTKLTDNIFLEILYSTDPNLNDARMILKKIESRNLYKFVGETQPMIQRIKKENYEHLPNEVASAKPSDVELEAELKAEDLIVDVINMDYGMEDK-NPIDHVRFYCKSDLSKAVMITRNQVSQFLPETFAEQLIRV 541
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. TrEMBL
Match: A0A3Q1HLR5 (HD domain-containing protein OS=Anabas testudineus OX=64144 PE=4 SV=1)

HSP 1 Score: 221.861 bits (564), Expect = 1.340e-60
Identity = 146/442 (33.03%), Postives = 239/442 (54.07%), Query Frame = 1 
Query:  616 NDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQ--PRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLI----------LGTYNKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDI--VKNEDARNELIETVIGPKVYD-------PKIWFSSDFISKVCDYHIWNIMSKYTSGIVEKIQERKLYKIFDQIQIKLDPKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTI 1878
            ND VHG ++    + +IIDTPQFQRLR+I+QLG  Y VYP A ++RFEHS+G  +LA EL + LK++ + E  ++I + ++  V+IA LCHDLGHGPFSH++E     + ++    +HE +S+E+F  L+   +   +  + +    +   ++FI+++I          L    + E+K F +EIV+NKT+G+DVDKFDY  RD  +LG  N     D +R L   R+ +  D GK H+ +RD+E+++++D F+ R+ LHR AYQH+  K IE M K  L+ +  +K E     L+E++     Y          I FS+D           N+  K    I+ +I  R LY    +  +    K       +  + ++ K +DF I+ V  ++ +      NP+  +NFY+K +P +      + +  L+    +ET + +
Sbjct:   40 NDSVHGHMEFHPLLVKIIDTPQFQRLRYIKQLGGAYFVYPGASHNRFEHSLGVGYLAGELAQALKTKHDNEGENLIDEKDILSVQIAGLCHDLGHGPFSHMFESVCPKKKVKCNSTEHEQISIEMFEHLVEENRLKPLMKLYDLSDRD---LHFIKEMIDLEPRGKDGKLRFEGRGEDKSFLYEIVSNKTNGVDVDKFDYFARDCHHLGMQNN---FDYRRFLKFARVCEAED-GKKHICIRDKEVYNMYDFFHTRYCLHRRAYQHRVNKAIEIMIKDVLSKVKDIKIEGFEKTLLESIDDMAAYTKLTDSLLQVILFSTD----------ENL--KEAKEILARICSRDLYVFLGETLVAESKKKIEWKKKL-AEPLRLKPEDFEIEQVTINYGMKER---NPIEKMNFYNKSDPQKAVPLPKEQVSHLLPDTFSETFIRV 458
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. TrEMBL
Match: A0A3Q1HLT1 (HD domain-containing protein OS=Anabas testudineus OX=64144 PE=4 SV=1)

HSP 1 Score: 219.935 bits (559), Expect = 5.953e-60
Identity = 146/444 (32.88%), Postives = 239/444 (53.83%), Query Frame = 1 
Query:  616 NDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLI----------LGTYNKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDI--VKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIM------SKYTSGIVEKIQERKLYKIFDQIQIKLDPKFQGQNGHIDLQEIKSKLKDFSIK-----SVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTI 1878
            ND VHG ++    + +IIDTPQFQRLR+I+QLG  Y VYP A ++RFEHS+G  +LA EL + LK++ + E  ++I + ++  V+IA LCHDLGHGPFSH++E  F        +HE +S+E+F  L+   +   +  + +    +   ++FI+++I          L    + E+K F +EIV+NKT+G+DVDKFDY  RD  +LG  N     D +R L   R+ +  D GK H+ +RD+E+++++D F+ R+ LHR AYQH+  K IE M K  L+ +  +K E     L+E++     Y           +K+ D  +  I+       K    I+ +I  R LY    +  I+   K          + ++ K +DF I+      +  + + G + + NP+  +NFY+K +P +      + +  L+    +ET + +
Sbjct:   45 NDSVHGHMEFHPLLVKIIDTPQFQRLRYIKQLGGAYFVYPGASHNRFEHSLGVGYLAGELAQALKTKHDNEGENLIDEKDILSVQIAGLCHDLGHGPFSHMFESVFSV-----LQHEQISIEMFEHLVEENRLKPLMKLYDLSDRD---LHFIKEMIDLEPRGKDGKLRFEGRGEDKSFLYEIVSNKTNGVDVDKFDYFARDCHHLGMQNN---FDYRRFLKFARVCEAED-GKKHICIRDKEVYNMYDFFHTRYCLHRRAYQHRVNKAIEIMIKDVLSKVKDIKIEGFEKTLLESIDDMAAY-----------TKLTDSLLQVILFSTDENLKEAKEILARICSRDLYVFLGETLIEWKKKLA--------EPLRLKPEDFEIEVGSYLHLQVTINYGMKER-NPIEKMNFYNKSDPQKAVPLPKEQVSHLLPDTFSETFIRV 456
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. TrEMBL
Match: A0A3Q4G7S4 (HD domain-containing protein OS=Neolamprologus brichardi OX=32507 PE=4 SV=1)

HSP 1 Score: 216.468 bits (550), Expect = 1.951e-58
Identity = 149/454 (32.82%), Postives = 243/454 (53.52%), Query Frame = 1 
Query:  616 NDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR----KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLI----------LGTY-NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAAL---NDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSG-------IVEKIQERKLYKIFDQIQI--------KLDPKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTI 1878
            ND +HG I+L   + +IIDTPQFQRLR+I+QLG GY V+P A ++RFEHSIG  HLA EL K LK  + + ++D I++ +V CV+IA LCHDLGHGPFSH+++  F+ +   P     KHED S+E+F  L+      +       I      + FI+++I          L  Y  +DE K F +EIV+NK +G+DVDKFDY  RD  +LG  N     D +R +   R+   +  G+ H+  RD+E+ +++D+F+ R+ LHR AYQH+  K +E M K AL   +  +  + +   ++         +     +   I ++   H  +  +++T         I+++I  R LY+   + ++        K+ P+         ++  KS +   S+ +V  +   G +NK +P+ +  FY+K  P+E F  + + +  L+ +   E +L +
Sbjct:   43 NDPIHGHIELHPLLVKIIDTPQFQRLRNIKQLGGGYFVFPGASHNRFEHSIGVGHLAGELAKTLK--LKQPELD-INERDVLCVQIAGLCHDLGHGPFSHLFDGMFNPEA-DPEHKDWKHEDASLEMFDHLVVASGLAQEMERYGLILPPD--LTFIKEMIKPLKSDDAEVLWPYEGRDENKSFLYEIVSNKQNGIDVDKFDYFARDCHHLGIRNN---FDHQRFIMFARVCDVN--GRKHICSRDKEVANLYDMFHTRNSLHRRAYQHRVTKSVEIMIKDALLKADQYILTKGSGGTMLCLSKAKTDMEAYTKLTDQMIERI--LHPCSCSNEFTPSPLEEARMILQRIMSRDLYQFVGETKVCNQGWTGTKIWPRLFWPTHSKHIKCHKSHISKLSLATVV-TLDYGMKNK-DPINTTYFYTKAKPTEAFKISREQVSKLLPVCFAEKILRV 481
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. TrEMBL
Match: A0A1L8EU46 (HD domain-containing protein OS=Xenopus laevis OX=8355 GN=XELAEV_18043967mg PE=4 SV=1)

HSP 1 Score: 214.542 bits (545), Expect = 3.703e-58
Identity = 156/437 (35.70%), Postives = 235/437 (53.78%), Query Frame = 1 
Query:  616 NDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDM-ISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGT-------------YNKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTG-KWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDI-----VKNEDARNELIETVIG-----PKVYDP---KIWFSSDFISKVCDYHIWNIMSKYTSGIVEKIQERKLYKIFDQIQIKLDPKFQGQNGHIDLQEIKSKL--KDFSIKSVCSSFSV-------GSENKGNPLLSVNFYSKENPSECFN 1815
            ND VHG I+L   +  IIDTP+FQRLR+I+QLG  Y V+P A ++RFEHSIG  HLA  L ++L+ +    + D+ I+D ++ CV+IA LCHDLGHGPFSH++E  F + T    KHED+SV++F  L+         +   K +++   + FI++LI+G                + EEK F +EIVANK +G+DVDKFDY  RD  +LG  N     D KR L   R+    D G + H+ +RD+E+++++++FY R+ L+R A  H+ V VIE M   A         ++  +  +  I   +       K+ D    +I +SSD  SK+ D             I+EKI +RK YK   +     +   Q  +    L+E+   +  +D +++     F V       G + K NP+  V+FYSK +P E F+
Sbjct:   11 NDPVHGHIELHPLLVRIIDTPEFQRLRYIKQLGGIYYVFPGASHNRFEHSIGVGHLAGCLARELRDR----QTDLGITDTDILCVQIAGLCHDLGHGPFSHLFEKQFTTYTKPEFKHEDVSVKMFDHLI--------ASNNLKEEISESDLIFIKELIMGCPLSDELKQEVWPYAGRPEEKSFLYEIVANKENGIDVDKFDYFARDCYHLGIQNN---FDYKRFLKFARVC---DVGNRKHICVRDKEVWNLYNMFYTRYGLYRRACHHRVVNVIEIMIGEAFRKADQYIQIEGSNGGSFTISKAVDDMAAYTKLTDAIFVQILYSSD--SKLSD----------AKKILEKIVQRKFYKYLGEATPNPN-NTQSLDKKQLLEELAKAVAAEDPNMRCTSEDFVVDVFLMDYGMKEK-NPIDKVHFYSKNDPKEAFH 415
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. TrEMBL
Match: A0A3Q4G7R6 (HD domain-containing protein OS=Neolamprologus brichardi OX=32507 PE=4 SV=1)

HSP 1 Score: 215.312 bits (547), Expect = 5.171e-58
Identity = 147/452 (32.52%), Postives = 241/452 (53.32%), Query Frame = 1 
Query:  616 NDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR----KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLI---------LGTYNKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAAL---NDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSG-------IVEKIQERKLYKIFDQIQI--------KLDPKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTI 1878
            ND +HG I+L   + +IIDTPQFQRLR+I+QLG GY V+P A ++RFEHSIG  HLA EL K LK  + + ++D I++ +V CV+IA LCHDLGHGPFSH+++  F+ +   P     KHED S+E+F  L+      +       I      + FI+++I              +DE K F +EIV+NK +G+DVDKFDY  RD  +LG  N     D +R +   R+   +  G+ H+  RD+E+ +++D+F+ R+ LHR AYQH+  K +E M K AL   +  +  + +   ++         +     +   I ++   H  +  +++T         I+++I  R LY+   + ++        K+ P+         ++  KS +   S+ +V  +   G +NK +P+ +  FY+K  P+E F  + + +  L+ +   E +L +
Sbjct:   36 NDPIHGHIELHPLLVKIIDTPQFQRLRNIKQLGGGYFVFPGASHNRFEHSIGVGHLAGELAKTLK--LKQPELD-INERDVLCVQIAGLCHDLGHGPFSHLFDGMFNPEA-DPEHKDWKHEDASLEMFDHLVVASGLAQEMERYGLILPPD--LTFIKEMIKPLKSDDAEWPYEGRDENKSFLYEIVSNKQNGIDVDKFDYFARDCHHLGIRNN---FDHQRFIMFARVCDVN--GRKHICSRDKEVANLYDMFHTRNSLHRRAYQHRVTKSVEIMIKDALLKADQYILTKGSGGTMLCLSKAKTDMEAYTKLTDQMIERI--LHPCSCSNEFTPSPLEEARMILQRIMSRDLYQFVGETKVCNQGWTGTKIWPRLFWPTHSKHIKCHKSHISKLSLATVV-TLDYGMKNK-DPINTTYFYTKAKPTEAFKISREQVSKLLPVCFAEKILRV 472
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Cavefish
Match: ENSAMXT00000032130.1 (deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like [Source:NCBI gene;Acc:103028826])

HSP 1 Score: 206.453 bits (524), Expect = 6.924e-57
Identity = 156/472 (33.05%), Postives = 255/472 (54.03%), Query Frame = 1 
Query:  538 IKKLMENEKVVTKKMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMIN--FIEKLILGTY---------NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSGIVEKIQERKLYKI-----FDQIQIK-LDPKFQG--------QNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLV--KLVENETVL 1872
            +K + +++    +  T+   +     ND VHG I++   + +IIDTP+FQRLR+I+QLG GY VYP A ++RFEHS+G  HLA +L++ LK  +  E +++  +DE+ CV+IAALCHDLGHGPFSH ++  F  +     KHED SV++F  L+      EI   + K        +  FI +LI G            +D++K F ++IVAN  +G+DVDK DY  RD  +LG    N  H+  R +   R+    + G+  + MRD+E  +++++F+ R+LLH  AYQH+ VK +E M   AL +    +D  N L E  + PK +   ++ + D + K+ +     +  +    I++++ +R LYK+     F+  ++K LD   +         +N    +   K   +DF+   V   F+ G ++K NP+ S+ FY K +P+     + D +  L+  K  E + +L
Sbjct:    1 MKTMAQSKPQGEQSTTKKEKAIYKVFNDSVHGHIEMHPLLVKIIDTPEFQRLRNIKQLGGGYYVYPGASHNRFEHSLGVAHLAGKLLQSLKKTL-PEGLEITPNDEL-CVQIAALCHDLGHGPFSHAFD-IFMKKLDSSWKHEDASVKMFKHLIEENGIKEIMARENKDWDAFSEKDFMFIMELIQGPSKSASEWPYKGRDKKKAFLYDIVANHRNGIDVDKMDYFTRDCHHLGMKC-NFSHE--RFITFARVC--DENGETQICMRDKEAMNMYELFHVRNLLHHNAYQHRVVKAVELMIMDALKEA---KDHLN-LKEATMDPKTF---VYLTDDILQKILNKPEKKL--EKAQKIIKRVLKRDLYKLLGVKTFEPQELKHLDSDEEWKKVLETWLENIQTPVGARKLNPEDFT--EVQVKFNYGMKDK-NPIDSLRFYRKYDPNTPIKLSKDEVSHLLPEKFAETKVML 452
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Cavefish
Match: ENSAMXT00000041115.1 (deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like [Source:NCBI gene;Acc:111197473])

HSP 1 Score: 189.504 bits (480), Expect = 2.320e-53
Identity = 129/358 (36.03%), Postives = 205/358 (57.26%), Query Frame = 1 
Query:  580 MTEARNSTDSF--VNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWE---HAFDSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXX--XXXXXXMINFIEKLILGTYN-----KDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSGIVEKIQERKLYKIF 1617
            M +   ST  +   ND VHG I++   + +IIDTP+FQR R+I+QLG  Y VYP A ++RFEHS+G  HLA +L++ LK  +  E +++  +DE+ CV+IAALCHDLGHGPFSH ++     FDS+     KHED S+E+F  L+      +I   + K     + E   FI+KLI GT       ++++K F ++IVAN  +G+DVDK DY  RD  +LG    N  H+  R +   R+ +  + G+  + MRD+E  +++++F+ R+LLH  A QH+ VK +E M    + D +K  +   +L E    P+ +   +  + D + ++      +   +    I++++ +R LYK  
Sbjct:    1 MADQPTSTQVYKVFNDSVHGHIEMHPLLVKIIDTPEFQRSRNIKQLGGVYYVYPGASHNRFEHSLGVAHLAGKLLQSLKKNL-PEGLEITPNDEL-CVQIAALCHDLGHGPFSHAFDIFMKDFDSKW----KHEDASIEMFDHLIQKNGIKKIMEEENKDWDAFSEEHFMFIKKLIRGTKTEQPNEEEKKKAFLYDIVANYRNGIDVDKMDYFTRDCHHLGMKC-NFSHE--RFITFARVCE--ENGETQICMRDKEAMNMYEIFHVRNLLHHNACQHRVVKAVELM----IMDALKEANDHFKLKEKASKPETF---VHLTDDILLEILRTPKKSTKVEKAQKIIKRLLKRDLYKFL 340
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Cavefish
Match: ENSAMXT00000045292.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000081.1:2518931:2530795:1 gene:ENSAMXG00000031001.1 transcript:ENSAMXT00000045292.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 187.578 bits (475), Expect = 1.028e-51
Identity = 142/442 (32.13%), Postives = 219/442 (49.55%), Query Frame = 1 
Query:  580 MTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR-KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTY---------------NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIETVIGPKVYDPKIWFS-SDFI-SKVCDYHIWNIMSKYTSGIVEKIQERKLYKIFD------------QIQIKLDPKFQGQNGHI----DLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPS 1803
            M    N  +    D VHG I L   +  IIDTPQFQRLR+I+QLG GY V+P A ++RFEHSIG  HLA +L++ L++     ++++   DE+ CV+IA LCHDLGHGPFSHV+E     +  +   KHE++SV +F  L+      EI   +           FI +LI                    + +EK + ++IV N+T+G+DVDK DY  RD  +LG    N  H+  R L   R+    + G   + +RD+E  +++++F+ R  LH   Y H+  K +E M   AL        A NE +   I   V DP  +   +DFI  K+ D  + +       GI+E+I +R++YK  D             +    + K Q    H+       +++   +DF I  +    + G  N+ +P+  + FY ++ P+
Sbjct:    1 MAVQPNQVNKVFYDPVHGHIALDPLLVSIIDTPQFQRLRNIKQLGGGYFVFPGASHNRFEHSIGVAHLAGKLVQSLRTD---NELNITDTDEL-CVKIAGLCHDLGHGPFSHVFEGFMKEENPESNWKHEEMSVRMFDYLIEENGISEIMRNEYNFTDQD--FQFIRELIYTPKPPNNPNPENRQWSYTGRPQEKSYLYQIVNNQTTGIDVDKMDYFSRDCHHLGIKC-NFSHE--RYLVFARVCIDEELGT-QICIRDKEAMNMYELFHIRSYLHHNIYHHRVTKAVESMIVDALR-------AANERLS--ISAAVNDPSAYMKLTDFILQKILD--LADPEHPAAPGIIERISKREVYKFIDGKVFRPNDVRHVDLAESWEEKLQAWVEHVRNKAGGHQLEFNAQDFKIMPI--KINCG-RNEDDPISFLRFYRRDEPN 418
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Cavefish
Match: ENSAMXT00000040847.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000081.1:2469780:2530795:1 gene:ENSAMXG00000031001.1 transcript:ENSAMXT00000040847.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 187.578 bits (475), Expect = 1.028e-51
Identity = 142/442 (32.13%), Postives = 219/442 (49.55%), Query Frame = 1 
Query:  580 MTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR-KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTY---------------NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIETVIGPKVYDPKIWFS-SDFI-SKVCDYHIWNIMSKYTSGIVEKIQERKLYKIFD------------QIQIKLDPKFQGQNGHI----DLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPS 1803
            M    N  +    D VHG I L   +  IIDTPQFQRLR+I+QLG GY V+P A ++RFEHSIG  HLA +L++ L++     ++++   DE+ CV+IA LCHDLGHGPFSHV+E     +  +   KHE++SV +F  L+      EI   +           FI +LI                    + +EK + ++IV N+T+G+DVDK DY  RD  +LG    N  H+  R L   R+    + G   + +RD+E  +++++F+ R  LH   Y H+  K +E M   AL        A NE +   I   V DP  +   +DFI  K+ D  + +       GI+E+I +R++YK  D             +    + K Q    H+       +++   +DF I  +    + G  N+ +P+  + FY ++ P+
Sbjct:    1 MAVQPNQVNKVFYDPVHGHIALDPLLVSIIDTPQFQRLRNIKQLGGGYFVFPGASHNRFEHSIGVAHLAGKLVQSLRTD---NELNITDTDEL-CVKIAGLCHDLGHGPFSHVFEGFMKEENPESNWKHEEMSVRMFDYLIEENGISEIMRNEYNFTDQD--FQFIRELIYTPKPPNNPNPENRQWSYTGRPQEKSYLYQIVNNQTTGIDVDKMDYFSRDCHHLGIKC-NFSHE--RYLVFARVCIDEELGT-QICIRDKEAMNMYELFHIRSYLHHNIYHHRVTKAVESMIVDALR-------AANERLS--ISAAVNDPSAYMKLTDFILQKILD--LADPEHPAAPGIIERISKREVYKFIDGKVFRPNDVRHVDLAESWEEKLQAWVEHVRNKAGGHQLEFNAQDFKIMPI--KINCG-RNEDDPISFLRFYRRDEPN 418
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Cavefish
Match: ENSAMXT00000057570.1 (deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like [Source:NCBI gene;Acc:111191578])

HSP 1 Score: 185.267 bits (469), Expect = 6.924e-50
Identity = 126/360 (35.00%), Postives = 197/360 (54.72%), Query Frame = 1 
Query:  580 MTEARNSTDSF--VNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVK-CVEIAALCHDLGHGPFSHVWEHAFDS-QTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYN---------KDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSGIVEKIQERKLYKIFD 1620
            M +   ST  +   ND VHG I++   + +IIDTP+FQRLR+++Q G GY VYP A ++RFEHS+G  HLA +L++ LK      + D+  DDE + CV+IA LCHDLGHGPFSH ++   +  Q     KHED SV++F  L+       I   K  +K       FI++LI    +         + +EK F +EIVANK +G+DVDK DY  RD  +LG ++ N  H+  R +   R+    + G+ H+ MRD+E  +++++F+ R+L+ + A  H+  K +E M   AL +   +     E +         D     + D + ++      N+  K +  I+++I++R LY+  D
Sbjct:    1 MADQPTSTQVYKVFNDSVHGHIEMHPLLVKIIDTPEFQRLRNVKQFGGGYYVYPGASHNRFEHSLGVAHLAGKLVQNLKDS----QPDLGIDDEDELCVQIAGLCHDLGHGPFSHAFDDFMEQVQEDDKWKHEDQSVKMFDHLIIKGHIKGIMEKKYNLKNED--FEFIKELINPDKDNKTEWQFKGRTQEKSFLYEIVANKLTGIDVDKMDYFSRDCHHLGMTS-NFSHE--RYMMFARVC-TDENGEKHICMRDKEAVNMYELFHVRNLIRQRACHHRVAKAVELMITDALIEANSHFKLGEENLTICEAVNDLDTFTHLTDDILQEIERSTDDNL--KQSQEIIKRIRDRDLYRFVD 348
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Sea Lamprey
Match: samhd1 (SAM domain and HD domain 1 [Source:NCBI gene;Acc:553453])

HSP 1 Score: 190.274 bits (482), Expect = 2.491e-53
Identity = 149/462 (32.25%), Postives = 243/462 (52.60%), Query Frame = 1 
Query:  538 IKKLMENEKV--VTKKMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAF--DSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTY-----------NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAK-KSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAAL---NDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMS------KYTSGIVEKIQERKLYKIFDQIQ------------IKLDPKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECF 1812
            +KKL    KV  V K M +         ND +HG I +   +  IIDTPQFQRLR+I+QLG  Y V+P A ++RFEHS+G  +LA +L   ++S   ++    I++ +V CV+IA LCHDLGHGPFSH+++++F   ++     KHE  SV++F  L+      E    KE      E ++FI++ I G              + ++K F +EIVANK++G+DVDK+DY  RD  +LG  N     D +R +  +R+ + +++  K  +  R++E+ +++D+F+ R+ LHR AYQH+   +IE M K A    +  +K E +  ++  ++ G    D  + +     +K+ D   + I+       K    I+E +  R+LYK  +  Q            +KL  +       + L  +K   +DF +  +  +   G + K NP+ +V FY KE+P + F
Sbjct:   34 VKKLGNQLKVFQVLKIMCQDSKQNMKVFNDPIHGHIVMHPLLVRIIDTPQFQRLRNIKQLGGTYWVFPGASHNRFEHSMGVGYLAGQLATAIQS---RQPELGINERDVLCVQIAGLCHDLGHGPFSHMFDNSFIPAARPGCKWKHEVASVQMFDHLV-QANGLEEVLSKEYGLKLPEDLDFIKEQIAGPLADIADSKWPYKGRTKDKGFLYEIVANKSNGIDVDKWDYFARDCHHLGIQNN---FDHRRFIEFVRVCEVENERTKKVICFRNKEVGNLYDMFHTRNCLHRRAYQHRVGNIIELMIKEAFLKADKYIKIEGSGGKMF-SISG--AIDDMVAY-----TKLTDLIFYEILHSRDPNLKEARVILENVVCRRLYKFVNHTQPGEATLPKEPDEVKLAKEIANSEPEMPLN-VKLNPEDFVVHVI--NLDYGMKEK-NPINNVWFYCKEDPDKPF 476
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008965.1 (pep scaffold:Pmarinus_7.0:GL476766:34734:72987:-1 gene:ENSPMAG00000008111.1 transcript:ENSPMAT00000008965.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 175.252 bits (443), Expect = 2.962e-49
Identity = 110/277 (39.71%), Postives = 161/277 (58.12%), Query Frame = 1 
Query:  610 FVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLIL----GTYNKDEE----------KMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIE 1398
             +ND +HG+I+L + +  I+DTP+FQRLR I+QLG  + VYP+A ++RFEH IGT HLA +L++ LK + +KE    I+D +V CVEIA LCHDLGHGPFSH +E     + I+  KHE  SVE+   L+      +          +  ++  I  LI+    G  +   E          KMF FEIVAN  + +DVDKFDY  RD+ YLG+   N   + +R +   R+ +    G +H+    ++  ++ ++F+ R  LHR AYQH+  K+IE
Sbjct:    2 MINDPIHGLIELKKPLLLIVDTPEFQRLRFIKQLGLCHKVYPSAVHTRFEHCIGTSHLAGQLVRHLK-ECSKEH--NITDMDVLCVEIAGLCHDLGHGPFSHAFETVMKKKGIE-WKHELKSVEMLCHLIEKNSLQKDLENCGLQFPHHLIL--IASLIVAPKAGPLSSATEWLYIEKEYKCKMFLFEIVANDLNCIDVDKFDYFARDAYYLGF---NTGFEHQRYIQNARVCEFH--GDFHICQPKKQWSNLLELFHVRERLHRNAYQHRVTKLIE 267
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008964.1 (pep scaffold:Pmarinus_7.0:GL476766:34701:72987:-1 gene:ENSPMAG00000008111.1 transcript:ENSPMAT00000008964.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 174.481 bits (441), Expect = 5.116e-49
Identity = 110/278 (39.57%), Postives = 162/278 (58.27%), Query Frame = 1 
Query:  610 FVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGT------------YNKDEE---KMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIE 1398
             +ND +HG+I+L + +  I+DTP+FQRLR I+QLG  + VYP+A ++RFEH IGT HLA +L++ LK + +KE    I+D +V CVEIA LCHDLGHGPFSH +E     + I+  KHE  SVE+   L+      +          +  ++  I  LI+              Y  ++E   KMF FEIVAN  + +DVDKFDY  RD+ YLG+   N   + +R +   R+ +    G +H+    ++  ++ ++F+ R  LHR AYQH+  K+IE
Sbjct:    2 MINDPIHGLIELKKPLLLIVDTPEFQRLRFIKQLGLCHKVYPSAVHTRFEHCIGTSHLAGQLVRHLK-ECSKEH--NITDMDVLCVEIAGLCHDLGHGPFSHAFETVMKKKGIE-WKHELKSVEMLCHLIEKNSLQKDLENCGLQFPHHLIL--IASLIVAGPLSSATCKIYFWYKIEKEYKCKMFLFEIVANDLNCIDVDKFDYFARDAYYLGF---NTGFEHQRYIQNARVCEFH--GDFHICQPKKQWSNLLELFHVRERLHRNAYQHRVTKLIE 268
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008967.1 (pep scaffold:Pmarinus_7.0:GL476766:55761:72987:-1 gene:ENSPMAG00000008111.1 transcript:ENSPMAT00000008967.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 150.214 bits (378), Expect = 3.337e-42
Identity = 87/193 (45.08%), Postives = 119/193 (61.66%), Query Frame = 1 
Query:  610 FVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYNKDEEKMFFFEIVANKTSGLDVDKFDYLCR 1188
             +ND +HG+I+L + +  I+DTP+FQRLR I+QLG  + VYP+A ++RFEH IGT HLA +L++ LK + +KE    I+D +V CVEIA LCHDLGHGPFSH +E     + I+  KHE  SVE+   L+      +     + I         + ++I   Y     KMF FEIVAN  + +DVDKFDY  R
Sbjct:    2 MINDPIHGLIELKKPLLLIVDTPEFQRLRFIKQLGLCHKVYPSAVHTRFEHCIGTSHLAGQLVRHLK-ECSKEH--NITDMDVLCVEIAGLCHDLGHGPFSHAFETVMKKKGIE-WKHELKSVEMLCHLIEKNSLQKDLENLKTITFLLLSKTTLTEIIEKEYKC---KMFLFEIVANDLNCIDVDKFDYFAR 187
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Nematostella
Match: EDO35455 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLH5])

HSP 1 Score: 192.2 bits (487), Expect = 8.874e-53
Identity = 148/453 (32.67%), Postives = 228/453 (50.33%), Query Frame = 1 
Query:  583 TEARNSTDSF--VNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR---KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYN--------------KDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMS------KYTSGIVEKIQERKLYKIFDQIQIK------------------LDPKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECF 1812
            ++A N+  S    ND +HG I +     +IIDTPQFQRLR+++QLG  Y V+P A ++RFEHSIGT HLA EL++ ++ Q  +  +  +   +V CV+IA LCHDLGHGPFSH+++  F     +P    KHE  SV++F  L+      ++     +  L+ + + FI++LI G  N              +  EK + +EIVANK +G+DVDK+DY  RD   LG  N     D KR + L R+ K     +  + +RD+E  +I+D+F+ R  L + AYQHKT  +IE M   A     K+     +  + +   +  D  + +      K+ D+  + I+       +    I++ I++R LYK   Q  +K                  + P   G    ID  ++   L          SF  G +++ NP+  + FYSK+N SE F
Sbjct:  112 SQASNAVSSLKVFNDPIHGHIDVHPLCVKIIDTPQFQRLRNLKQLGGCYFVFPGAAHNRFEHSIGTSHLAGELLESIREQQPELGITYV---DVLCVKIAGLCHDLGHGPFSHMFDAGF-IPAARPGCDWKHEQASVDMFNYLV---DDNKLSEEFRRYGLSDKDMEFIQELIAGPRNMETPLKTQDWPYTGRSVEKSYLYEIVANKRTGIDVDKWDYFARDCHNLGIRNS---FDHKRFMKLARVIKVGK--RQQICIRDKEAGNIYDMFHTRTSLFKRAYQHKTANIIETMITEAFLKADKHLLFPGKNGKMLKMSEAIDDMVAYC-----KLSDHVFYQILHSTDPQLQKAREILQCIEKRDLYKCVGQTIMKQRRDKEEIPDIRREIIDAIPPDVLGGGRAIDSDDVIIHL---------ISFDYGMKDR-NPIDELRFYSKDNLSEAF 537
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Nematostella
Match: EDO35454 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLH4])

HSP 1 Score: 188.348 bits (477), Expect = 2.182e-52
Identity = 144/439 (32.80%), Postives = 223/439 (50.80%), Query Frame = 1 
Query:  616 NDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR---KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYNKDE--------------EKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMS------KYTSGIVEKIQERKLYKIFDQIQIKLDPKFQGQNGHIDLQEIKSKLKDFSIKSVCS---------------SFSVGSENKGNPLLSVNFYSKENPSECFNY 1818
            ND +HG I +     +IIDTPQFQRLR+++QLG  Y V+P A ++RFEHSIGT HLA  L+K ++    ++    I+D +V CV+IA LCHDLGHGPFSH+++  F     +P    KHE  SV++F  L+   K  E          +   + FI++LI G  N +               EK + +EIVANK +G+DVDK+DY  RD   LG  N     D KR + L R+ K     +  + +RD+E  +I+D+F+ R  L + AYQHKT  +IE M   A     K+     +  + +   +  D  + +      K+ D+  + I+       +    I++ I++R LYK   Q  +K       Q    ++ +I+ ++ D     + +               SF  G +++ NP+  + FY+K+N SE F +
Sbjct:   74 NDPIHGHIDVHPLCVKIIDTPQFQRLRNLKQLGGCYFVFPGAAHNRFEHSIGTSHLAGGLLKSIR---KRQPGLGITDVDVLCVKIAGLCHDLGHGPFSHMFDAGF-IPAARPGCDWKHEQASVDMFNYLVDDNKLLEEFRRYGLSDKD---MEFIQELIAGPRNMETPLKTQDWPYTGRSIEKSYLYEIVANKRTGIDVDKWDYFARDCHNLGIRNS---FDHKRFMKLARVIKVGK--RQQICIRDKEAGNIYDMFHTRTSLFKRAYQHKTANIIETMITEAFLKADKHLLFPGKNGKMLKMSEAIDDMVAYC-----KLSDHVFYQILHSTDPQLQEARRILQCIEKRDLYKCVGQTIMK-------QRRDKEIPDIRKEIIDAIPPDILAVGRAIDSDDVIIHLISFDYGMKDR-NPIDELRFYTKDNLSEAFVF 487
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Nematostella
Match: EDO26257 (pep supercontig:ASM20922v1:NEMVEscaffold_7765:3208:3433:-1 gene:NEMVEDRAFT_v1g154803 transcript:EDO26257 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 65.4698 bits (158), Expect = 1.156e-13
Identity = 30/52 (57.69%), Postives = 39/52 (75.00%), Query Frame = 1 
Query:  616 NDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIG 771
            ND +HG I +     +IIDTPQFQRLR+++QLG  Y V+P A ++RFEHSIG
Sbjct:    4 NDPIHGHIDVHPLCVKIIDTPQFQRLRNLKQLGGCYFVFPGAAHNRFEHSIG 55
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Medaka
Match: samhd1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:NCBI gene;Acc:101159989])

HSP 1 Score: 197.593 bits (501), Expect = 2.086e-54
Identity = 138/431 (32.02%), Postives = 222/431 (51.51%), Query Frame = 1 
Query:  616 NDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR---KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYN------------KDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAAL---NDIVKNEDARNEL--IETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSGIVE------KIQERKLYKIFDQIQIKL--------DPKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSE 1806
            ND +HG ++L   + +IIDTPQFQRLR+I+QLG  Y V+P A ++RFEHSIG  +LA +L++ L     ++   +I   ++ CV+IA LCHDLGHGPFSH+++  F  +   P+   KHE  S+++F  L+       +      +      ++FI++ I G  +            + E+K F +EIVANK +G+DVDK+DY  RD  +LG  N     D +R L   R+ +    G+ H+  RD+E+ +++D+F+ R+ LHR AYQHK   +IE M   A    +  ++ E    ++  + T I   V            +K+ DY    I++  +S + E       I  R+LYK   Q Q           +   Q  +  + LQ      +DF +  +   + +  +   NP+ +V FY K +P++
Sbjct:   82 NDPIHGHVELHPLLIKIIDTPQFQRLRNIKQLGGTYFVFPGASHNRFEHSIGVGYLAGQLVQALNE---RQPELLICHRDILCVQIAGLCHDLGHGPFSHMFDGMFIPKAC-PQVNWKHETASLDMFDHLVESNGLKVVMEEHGLVLPED--LDFIKEQIAGPLSTQTPGQKWPYKGRPEDKSFLYEIVANKRNGIDVDKWDYFARDCYHLGIQNN---FDYQRFLKFARVCEVD--GQKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVCNIIETMITEAFLKADPYIQIEGTEGKMFTLSTAIDDMVA----------YTKLTDYVFEQILNSSSSELREAREILHNIVCRRLYKCLGQTQPDQTIWEQELSESTPQNSSSAVSLQP-----QDFIVNVIVMDYGMKEK---NPINNVRFYCKNDPNK 483
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Medaka
Match: samhd1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:NCBI gene;Acc:101159989])

HSP 1 Score: 198.364 bits (503), Expect = 2.254e-54
Identity = 146/491 (29.74%), Postives = 240/491 (48.88%), Query Frame = 1 
Query:  487 DVDFVIISLIILDFRKKIKKLMENEKVVTKKMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPR---KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYN------------KDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAAL---NDIVKNEDARNEL--IETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSGIVE------KIQERKLYKIFDQIQIKLDPKFQGQNGHIDLQEIKS------------KLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLV 1845
            D D   I +  L  R +I   +       +K+ +     +   ND +HG ++L   + +IIDTPQFQRLR+I+QLG  Y V+P A ++RFEHSIG  +LA +L++ L     ++   +I   ++ CV+IA LCHDLGHGPFSH+++  F  +   P+   KHE  S+++F  L+       +      +      ++FI++ I G  +            + E+K F +EIVANK +G+DVDK+DY  RD  +LG  N     D +R L   R+ +    G+ H+  RD+E+ +++D+F+ R+ LHR AYQHK   +IE M   A    +  ++ E    ++  + T I   V            +K+ DY    I++  +S + E       I  R+LYK   Q Q         +   I  QE+              + +DF +  +   + +  +   NP+ +V FY K +P++      + +  L+
Sbjct:   75 DADLKTIGIECLGVRLRILHSL-------RKLWQIDTEANKVFNDPIHGHVELHPLLIKIIDTPQFQRLRNIKQLGGTYFVFPGASHNRFEHSIGVGYLAGQLVQALNE---RQPELLICHRDILCVQIAGLCHDLGHGPFSHMFDGMFIPKAC-PQVNWKHETASLDMFDHLVESNGLKVVMEEHGLVLPED--LDFIKEQIAGPLSTQTPGQKWPYKGRPEDKSFLYEIVANKRNGIDVDKWDYFARDCYHLGIQNN---FDYQRFLKFARVCEVD--GQKHICTRDKEVGNLYDMFHTRNCLHRRAYQHKVCNIIETMITEAFLKADPYIQIEGTEGKMFTLSTAIDDMVA----------YTKLTDYVFEQILNSSSSELREAREILHNIVCRRLYKCLGQTQPDQTVTVSQETIKIWEQELSESTPQNSSSAVSLQPQDFIVNVIVMDYGMKEK---NPINNVRFYCKNDPNKAIQIRKNQVSKLL 534
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Medaka
Match: ENSORLT00000044675.1 (deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like [Source:NCBI gene;Acc:101162528])

HSP 1 Score: 92.4337 bits (228), Expect = 1.364e-19
Identity = 97/332 (29.22%), Postives = 157/332 (47.29%), Query Frame = 1 
Query:  958 KHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGT-----------------YNKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRI--AKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAAL---NDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTS------GIVEKIQERKLYKIFDQI--QIKLDPKFQGQNGHIDLQ-----EIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKEN-PSECFNYTDDNLPDLV 1845
            +HED SVE+F  LL   +    +    +++ N  +  FI++LILG                    + E+K F +EIV+NK +G+DVDKFDY  RD  +LG  N     D  R     R+   +K+   + H+  RD+E  +++D+FY R  LHR AYQHK  K +E M K AL   N  +K +    E  E      + D K   + +  +++ D     I+   +S       I+E+I+ R LY++ D+   Q K   K   +    +L+     E++    D+  + V  ++S G  +K +P+    FY K+  P E F  T   + + +
Sbjct:   30 RHEDASVEMFQYLLEKNRELLTEMKNSRLEDNDLV--FIKELILGEPLKKKSDKPEDPSDWPYEGRGEDKSFLYEIVSNKQNGIDVDKFDYFARDCHHLGLKNN---FDHMRYFKFTRVIGVEKNKLKRKHICSRDKEAGNLYDLFYTRDRLHRRAYQHKVTKNVEIMIKDALLKANKHIKFKGKDKEKKENFFT--ISDAKD--NMEAYTQLTDQVTQRILESSSSELEQARNILERIKTRDLYELVDEAKGQNKQHKKISKETITNELKVVLPGEVRDHHNDY-FEVVLVTYSYGKGDK-DPVECSYFYKKDGEPPEAFQITRQQVSNFL 350
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Planmine SMEST
Match: SMESG000079583.1 (SMESG000079583.1)

HSP 1 Score: 887.1 bits (2291), Expect = 0.000e+0
Identity = 464/473 (98.10%), Postives = 469/473 (99.15%), Query Frame = 1 
Query:  580 MTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYNKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSGIVEKIQERKLYKIFDQIQIKLDPKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTIXXXXXXXXXXXXXXXXXMDNLINRKIASLREKYIFKKMLY 1998
            MTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRKHEDLSVE+FLRLLYHKKTGEIKNIKEKIKLNTEMINFIEKLILGTYNKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIV NEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSGIVEKIQERKLYKIFDQIQIKLDP FQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTILTET+P EETK++LKTLMDNLINRKIASLREKY FK+MLY
Sbjct:    1 MTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRKHEDLSVEMFLRLLYHKKTGEIKNIKEKIKLNTEMINFIEKLILGTYNKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVHNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSGIVEKIQERKLYKIFDQIQIKLDPNFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTILTETKPDEETKKQLKTLMDNLINRKIASLREKYTFKRMLY 473
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Planmine SMEST
Match: SMESG000079585.1 (SMESG000079585.1)

HSP 1 Score: 788.489 bits (2035), Expect = 0.000e+0
Identity = 416/430 (96.74%), Postives = 424/430 (98.60%), Query Frame = 1 
Query:  709 LGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYNKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSGIVEKIQERKLYKIFDQIQIKLDPKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTIXXXXXXXXXXXXXXXXXMDNLINRKIASLREKYIFKKMLY 1998
            +GFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTI  RKHEDLSVE+FLRLLYHKKTGEIKNIKEKIKLNTEMINFIEKLILGTYNKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIV NEDARNELIETVIGPKVYDPKIWFSS+FISKVCDYHIWNIMSKYTSGIVEKIQERKLYKIFDQIQIKLDP FQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTILTET+P EETK++LKTLMD+LINRKIASLREKY FK+MLY
Sbjct:    1 MGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIPSRKHEDLSVEMFLRLLYHKKTGEIKNIKEKIKLNTEMINFIEKLILGTYNKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVHNEDARNELIETVIGPKVYDPKIWFSSEFISKVCDYHIWNIMSKYTSGIVEKIQERKLYKIFDQIQIKLDPNFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTILTETKPNEETKKQLKTLMDDLINRKIASLREKYTFKRMLY 430
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Planmine SMEST
Match: SMESG000079667.1 (SMESG000079667.1)

HSP 1 Score: 700.664 bits (1807), Expect = 0.000e+0
Identity = 359/476 (75.42%), Postives = 411/476 (86.34%), Query Frame = 1 
Query:  577 KMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTYNK--DEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSGIVEKIQERKLYKIFDQIQIKLDPKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTIXXXXXXXXXXXXXXXXXMDNLINRKIASLREKYIFKKMLY 1998
            +++++ +   +FVNDIVHGIIKLP YIKEIID+PQFQRLRHIRQLGFGY VY +AGYSRFEHSIGTFHLASELIKQLK+Q +++K   ISD++VKCVEIAALCHDLGHGP+SH WEHAFD++TI+PRKHEDLSVEIF  LL H K+ E + IK+KI L    I+ I+++ILG ++K  D+++MF FEIVANK SGLDVDKFDYLCRDSIY GWSNKNKIHDIKRILH LRIAKKSD   WHLAMRDREIFHIHDVFYYRHLLHRY YQHKTVK+IECMF  ALNDIV NEDARNELIETVIGPKVYDPKIWFSS+FISKVCDYHIWNIMSKYTSGIVE+IQERKLYKIFDQIQI+L+P FQGQ GHIDLQEIKSKLKDF IK V SSF++ SEN+GNPLLSVNFY+K+NP +C NY +++LPDLVKL  +E VL I TET P +ET+  L+TL  NL + +I  LREKYIF+  LY
Sbjct:    4 QLSQSEDPETTFVNDIVHGIIKLPVYIKEIIDSPQFQRLRHIRQLGFGYFVYSSAGYSRFEHSIGTFHLASELIKQLKNQTDQDKEIEISDEDVKCVEIAALCHDLGHGPYSHFWEHAFDNETIEPRKHEDLSVEIFSMLLEHIKSDETQKIKDKIGLKKNTIDLIKRIILGNFDKEIDKKRMFLFEIVANKCSGLDVDKFDYLCRDSIYFGWSNKNKIHDIKRILHFLRIAKKSDM--WHLAMRDREIFHIHDVFYYRHLLHRYGYQHKTVKIIECMFNDALNDIVHNEDARNELIETVIGPKVYDPKIWFSSEFISKVCDYHIWNIMSKYTSGIVERIQERKLYKIFDQIQIELNPNFQGQKGHIDLQEIKSKLKDFPIKFVISSFALQSENRGNPLLSVNFYTKQNPLKCTNYEEESLPDLVKLKGDEIVLMIFTETIPNKETERMLRTLKANLCSNEIEGLREKYIFRAKLY 477
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Planmine SMEST
Match: SMESG000079633.1 (SMESG000079633.1)

HSP 1 Score: 443.736 bits (1140), Expect = 1.963e-149
Identity = 235/430 (54.65%), Postives = 302/430 (70.23%), Query Frame = 1 
Query:  613 VNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFD-SQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTY--NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIETVIGPKV-YDPKIWFSSDFISKVCDYHIWNIMSKYTSGIVEKIQERKLYKIF--DQIQIKLDPKFQGQNGHI-DLQEIKSKLKDFS-IKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTI 1878
            +NDIVHG I LPEY+K IIDT +FQRLR+I Q+G    +YP+A  SRFEHS+GTF+LAS+LIKQLK Q+  E   +I+ +EVKCVE+AALCHDLGHGP SH WEHAFD S  I+ RKHED+SVEIF  L+  KK+   + IK  I L  EMI+ I ++I G Y   KD EK F F+IVANK SGLDVDK DYLCRDS YLGWSN NKIHD KR+++  R+ K   T  WHLAMRDRE+F +++VF +RH+LHRY  QH+ VK IECMF+  +  +++N  AR+E +ETV+  KV Y+  IWFS  FISKV DYH+W+++ KY   + + IQER LYK+    QIQI     F   +  I DLQ    +    S I    S +S+ +ENKG+PL+ + FYSKENP++ FNY  D+LP+ + L E+E +L +
Sbjct:    2 INDIVHGTITLPEYVKVIIDTEEFQRLRYISQIGLTRHIYPSATCSRFEHSLGTFYLASKLIKQLKDQLESEDKLIITSEEVKCVELAALCHDLGHGPHSHFWEHAFDPSLKIKTRKHEDVSVEIFRELVDQKKSTSTETIKTIIGLTEEMIDQICRMITGEYEREKDGEKKFLFQIVANKDSGLDVDKLDYLCRDSFYLGWSN-NKIHDFKRLIYFFRVVKDESTKDWHLAMRDRELFKVNEVFSFRHILHRYGCQHRVVKSIECMFRNGIKQVIENTVARDEFLETVLEQKVPYNSDIWFSKQFISKVNDYHLWHVLKKYAKEMFKNIQERNLYKLLHQSQIQITSGNNFDSLDNDISDLQTFLQRTSGHSNIYLSLSIYSLQTENKGDPLMLMKFYSKENPNKSFNYDKDSLPNSLSLKEDEIILMV 430
[Close]
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Planmine SMEST
Match: SMESG000079627.1 (SMESG000079627.1)

HSP 1 Score: 441.039 bits (1133), Expect = 3.173e-148
Identity = 234/433 (54.04%), Postives = 304/433 (70.21%), Query Frame = 1 
Query:  604 DSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRHIRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISDDEVKCVEIAALCHDLGHGPFSHVWEHAFD-SQTIQPRKHEDLSVEIFLRLLYHXXXXXXXXXXXXXXXXXXMINFIEKLILGTY--NKDEEKMFFFEIVANKTSGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLAMRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDARNELIETVIGPKV-YDPKIWFSSDFISKVCDYHIWNIMSKYTSGIVEKIQERKLYKIF--DQIQIKLDPKFQGQNGHI-DLQEIKSKLKDFS-IKSVCSSFSVGSENKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTI 1878
            ++ VNDIV+G I LPEY+KEIIDT +FQRLR+I Q G  + V P+A  SRFEHS+GTF+LAS+LIKQLK Q+  E   +I+ +EVKCVE+AALCHDLGHGP SH WEHAFD S  I+ RKHED+SVEIF  L+  KK+   + IK  I L  EMI+ I ++I G Y   KD EK F F+IVANK SGLDVDK DYLCRDS YLGWSN NKIHD KR+++  R+ K   T  WHLAMRDRE+F +++VF +RH+LHRY  +H+ VK IECMF+  +  +++N  AR+E +ETV+  KV Y+  IWFS  FISKV DYH+W+++ KY   + + IQER LYK+    QIQI     F   +  I DLQ    +    S I    S +S+ +ENKG+PL+ + FYSKENP++ F+Y  D+LP+ + L E+E +L +
Sbjct:    6 ETMVNDIVYGTITLPEYVKEIIDTQEFQRLRYISQTGLTWYVNPSATCSRFEHSLGTFYLASKLIKQLKDQLEGEDKLIITSEEVKCVELAALCHDLGHGPHSHFWEHAFDPSLKIKTRKHEDVSVEIFRELVDQKKSTSTETIKTIIGLTEEMIDQICRMITGEYEREKDGEKKFLFQIVANKDSGLDVDKLDYLCRDSFYLGWSN-NKIHDFKRLIYFFRVVKDESTKDWHLAMRDRELFKVNEVFSFRHILHRYGCKHRVVKSIECMFRNGIKQVIENTVARDEFLETVLEQKVPYNSDIWFSKQFISKVNDYHLWHVLKKYAKEMFKNIQERNLYKLLHQSQIQITSGNNFDSLDNDISDLQTFLQRTSGHSNIYLSLSIYSLQTENKGDPLMLMKFYSKENPNKSFDYDKDSLPNSLSLKEDEIILMV 437
The following BLAST results are available for this feature:
BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SAMHD13.242e-5132.98SAM and HD domain containing deoxynucleoside triph... [more]
SAMHD15.997e-5132.98SAM and HD domain containing deoxynucleoside triph... [more]
SAMHD15.997e-5132.98SAM and HD domain containing deoxynucleoside triph... [more]
SAMHD13.058e-5037.42SAM and HD domain containing deoxynucleoside triph... [more]
SAMHD14.350e-4937.10SAM and HD domain containing deoxynucleoside triph... [more]
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
ZK177.83.238e-3926.87pep chromosome:WBcel235:II:5509032:5513775:-1 gene... [more]
ZK177.83.238e-3926.87pep chromosome:WBcel235:II:5509028:5511208:-1 gene... [more]
ZK177.86.747e-3926.87pep chromosome:WBcel235:II:5509032:5513748:-1 gene... [more]
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
fal5.201e-2629.68gene:FBgn0028380 transcript:FBtr0347258[more]
fal5.201e-2629.68gene:FBgn0028380 transcript:FBtr0290284[more]
fal5.201e-2629.68gene:FBgn0028380 transcript:FBtr0321324[more]
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
si:ch73-236c18.91.117e-5333.76si:ch73-236c18.9 [Source:ZFIN;Acc:ZDB-GENE-121214-... [more]
si:ch73-236c18.82.343e-5332.97si:ch73-236c18.8 [Source:ZFIN;Acc:ZDB-GENE-121214-... [more]
samhd11.732e-5232.24SAM domain and HD domain 1 [Source:NCBI gene;Acc:5... [more]
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SAMHD18.060e-5532.96SAM domain and HD domain 1 [Source:NCBI gene;Acc:1... [more]
SAMHD14.061e-5432.96SAM domain and HD domain 1 [Source:NCBI gene;Acc:1... [more]
SAMHD16.229e-5432.39SAM domain and HD domain 1 [Source:NCBI gene;Acc:1... [more]
SAMHD11.899e-5332.10SAM domain and HD domain 1 [Source:NCBI gene;Acc:1... [more]
SAMHD12.510e-5332.45SAM domain and HD domain 1 [Source:NCBI gene;Acc:1... [more]
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Samhd16.861e-5131.24SAM domain and HD domain, 1 [Source:MGI Symbol;Acc... [more]
Samhd11.484e-5030.40SAM domain and HD domain, 1 [Source:MGI Symbol;Acc... [more]
Samhd11.518e-5030.40SAM domain and HD domain, 1 [Source:MGI Symbol;Acc... [more]
Samhd11.746e-5030.40SAM domain and HD domain, 1 [Source:MGI Symbol;Acc... [more]
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5ZJL9|SAMH1_CHICK4.250e-5532.33Deoxynucleoside triphosphate triphosphohydrolase S... [more]
sp|Q502K2|SAMH1_DANRE1.347e-5132.24Deoxynucleoside triphosphate triphosphohydrolase S... [more]
sp|Q6INN8|SAMH1_XENLA1.291e-5030.35Deoxynucleoside triphosphate triphosphohydrolase S... [more]
sp|Q9Y3Z3|SAMH1_HUMAN2.880e-5032.98Deoxynucleoside triphosphate triphosphohydrolase S... [more]
sp|Q0VCA5|SAMH1_BOVIN9.418e-5030.75Deoxynucleoside triphosphate triphosphohydrolase S... [more]
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A3Q1HLR51.340e-6033.03HD domain-containing protein OS=Anabas testudineus... [more]
A0A3Q1HLT15.953e-6032.88HD domain-containing protein OS=Anabas testudineus... [more]
A0A3Q4G7S41.951e-5832.82HD domain-containing protein OS=Neolamprologus bri... [more]
A0A1L8EU463.703e-5835.70HD domain-containing protein OS=Xenopus laevis OX=... [more]
A0A3Q4G7R65.171e-5832.52HD domain-containing protein OS=Neolamprologus bri... [more]
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSAMXT00000032130.16.924e-5733.05deoxynucleoside triphosphate triphosphohydrolase S... [more]
ENSAMXT00000041115.12.320e-5336.03deoxynucleoside triphosphate triphosphohydrolase S... [more]
ENSAMXT00000045292.11.028e-5132.13pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
ENSAMXT00000040847.11.028e-5132.13pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
ENSAMXT00000057570.16.924e-5035.00deoxynucleoside triphosphate triphosphohydrolase S... [more]
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4
Match NameE-valueIdentityDescription
samhd12.491e-5332.25SAM domain and HD domain 1 [Source:NCBI gene;Acc:5... [more]
ENSPMAT00000008965.12.962e-4939.71pep scaffold:Pmarinus_7.0:GL476766:34734:72987:-1 ... [more]
ENSPMAT00000008964.15.116e-4939.57pep scaffold:Pmarinus_7.0:GL476766:34701:72987:-1 ... [more]
ENSPMAT00000008967.13.337e-4245.08pep scaffold:Pmarinus_7.0:GL476766:55761:72987:-1 ... [more]
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO354558.874e-5332.67Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO354542.182e-5232.80Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO262571.156e-1357.69pep supercontig:ASM20922v1:NEMVEscaffold_7765:3208... [more]
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
samhd12.086e-5432.02SAM and HD domain containing deoxynucleoside triph... [more]
samhd12.254e-5429.74SAM and HD domain containing deoxynucleoside triph... [more]
ENSORLT00000044675.11.364e-1929.22deoxynucleoside triphosphate triphosphohydrolase S... [more]
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BLAST of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000079583.10.000e+098.10SMESG000079583.1[more]
SMESG000079585.10.000e+096.74SMESG000079585.1[more]
SMESG000079667.10.000e+075.42SMESG000079667.1[more]
SMESG000079633.11.963e-14954.65SMESG000079633.1[more]
SMESG000079627.13.173e-14854.04SMESG000079627.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30023897 ID=SMED30023897|Name=Deoxynucleoside triphosphate triphosphohydrolase SAMHD1|organism=Schmidtea mediterranea sexual|type=transcript|length=2128bp
GTAATTTTCGGCATACTAAAGAGATATGCTAAAAAGATTGCAAAGGTCTT
GGTGAAAAACCTAGTGACAGTGCAATTCCTGATTTTCCGGATCCAAAATA
ATTCTAGAAAGTACAAGATGTTTGTAGTAAATCGAATTGGTTTCATCAAA
GAAGGGACGAATTCACGACGATATCGGTATTTTCTCACTAAAGAAAACCC
AACTAATTTGATATCCCTGGGAATAACTGAACAATTGAAATTAAATTTTA
AAATTATATTTTAGTTGTTAAATTACATTTTATGTTATAGAAAACTTCTC
TTCTTTCTATATTTCTTTATATGTTAAACAAATAAATGCAAGATAAGCCT
TTACTGCAAAATGTGCAATAAATAGTTGTAAATATTGGTTTTCAATCTAG
TAAAGATTGAAGTCTTATCATTTATTTGTCCAAAATTTAATTTTTACTGA
TAGGGCGAAAACTAAATAAACTAAAAATCAAGTTTTGATGTAGATTTTGT
AATAATTTCATTGATTATTTTAGATTTTAGGAAGAAAATTAAAAAACTTA
TGGAAAACGAAAAAGTCGTAACCAAGAAAATGACAGAAGCAAGAAATTCT
ACAGATTCATTTGTCAATGACATTGTTCATGGAATAATCAAACTGCCGGA
ATATATAAAGGAGATCATCGACACTCCTCAATTCCAACGATTAAGACACA
TTCGCCAATTGGGATTCGGATATCTTGTGTACCCCACTGCTGGTTACTCG
AGATTTGAGCATTCCATAGGAACTTTTCATTTGGCCTCGGAGCTCATAAA
GCAATTAAAAAGTCAAATAAACAAAGAGAAAGTAGATATGATTTCAGATG
ATGAAGTAAAATGTGTAGAAATCGCAGCATTGTGCCATGACCTGGGTCAT
GGGCCCTTCTCTCACGTTTGGGAGCACGCATTCGACAGTCAAACCATTCA
ACCACGAAAACATGAAGATTTATCAGTCGAAATTTTTTTAAGGTTGCTCT
ATCATAAGAAAACCGGCGAGATTAAAAATATAAAAGAAAAAATAAAATTG
AATACGGAAATGATTAATTTTATAGAAAAATTAATTTTAGGAACATATAA
CAAAGATGAAGAGAAAATGTTTTTTTTTGAAATCGTTGCCAATAAAACTT
CAGGTTTAGACGTGGACAAATTTGACTATCTATGTCGGGACTCGATCTAC
TTAGGATGGTCAAATAAGAATAAAATTCACGATATCAAACGAATTCTGCA
CCTTTTACGGATTGCAAAGAAATCCGATACCGGCAAGTGGCATTTGGCAA
TGAGAGACAGGGAGATCTTTCACATTCACGACGTGTTTTATTACCGACAT
TTGCTGCATCGGTACGCATATCAACACAAAACTGTTAAGGTCATCGAATG
TATGTTTAAGGCGGCTCTGAATGATATAGTAAAGAATGAGGACGCCCGGA
ATGAGTTGATAGAAACTGTTATAGGACCGAAAGTTTATGACCCGAAAATT
TGGTTCAGTAGTGACTTCATTAGCAAAGTCTGTGATTACCACATTTGGAA
TATCATGAGTAAATACACAAGTGGCATAGTAGAAAAAATACAAGAAAGAA
AGCTTTACAAAATATTCGATCAAATCCAAATTAAACTCGATCCAAAATTT
CAAGGGCAAAACGGTCATATAGATCTCCAGGAAATCAAATCAAAACTCAA
AGACTTTTCTATAAAATCTGTCTGTTCTTCATTTTCTGTTGGGAGTGAAA
ATAAAGGCAATCCTTTGCTTTCTGTTAATTTTTACTCCAAGGAAAATCCA
TCTGAATGCTTCAATTACACAGATGATAATTTGCCGGATTTGGTGAAATT
GGTAGAGAATGAAACCGTTCTGACCATCTTAACTGAAACCGAACCAGGTG
AGGAAACCAAAGAAAAGTTGAAGACTTTAATGGATAATCTAATTAACAGA
AAAATTGCAAGTCTTCGCGAAAAGTATATATTTAAAAAGATGTTATATTA
GTTAGAACTGACAGTTTACATTTTGATATTTATTTTGGTTTATTTTGGTT
TAGCTTAAAAGTATCTTTAGGAATTTTATCTTAGTTAGTGATGACAATTT
ACATTTTGGTATTTATTTTGGTTTAGCC
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protein sequence of SMED30023897-orf-1

>SMED30023897-orf-1 ID=SMED30023897-orf-1|Name=SMED30023897-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=484bp
MENEKVVTKKMTEARNSTDSFVNDIVHGIIKLPEYIKEIIDTPQFQRLRH
IRQLGFGYLVYPTAGYSRFEHSIGTFHLASELIKQLKSQINKEKVDMISD
DEVKCVEIAALCHDLGHGPFSHVWEHAFDSQTIQPRKHEDLSVEIFLRLL
YHKKTGEIKNIKEKIKLNTEMINFIEKLILGTYNKDEEKMFFFEIVANKT
SGLDVDKFDYLCRDSIYLGWSNKNKIHDIKRILHLLRIAKKSDTGKWHLA
MRDREIFHIHDVFYYRHLLHRYAYQHKTVKVIECMFKAALNDIVKNEDAR
NELIETVIGPKVYDPKIWFSSDFISKVCDYHIWNIMSKYTSGIVEKIQER
KLYKIFDQIQIKLDPKFQGQNGHIDLQEIKSKLKDFSIKSVCSSFSVGSE
NKGNPLLSVNFYSKENPSECFNYTDDNLPDLVKLVENETVLTILTETEPG
EETKEKLKTLMDNLINRKIASLREKYIFKKMLY*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR003607HD/PDEase_dom
IPR006674HD_domain
Vocabulary: biological process
TermDefinition
GO:0002376immune system process
GO:0006203dGTP catabolic process
GO:0008152metabolic process
GO:0045087innate immune response
GO:0045088regulation of innate immune response
GO:0046061dATP catabolic process
GO:0051607defense response to virus
Vocabulary: molecular function
TermDefinition
GO:0003676nucleic acid binding
GO:0003723RNA binding
GO:0003824catalytic activity
GO:0008270zinc ion binding
GO:0008832dGTPase activity
GO:0016787hydrolase activity
GO:0032567dGTP binding
GO:0046872metal ion binding
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR003607HD/PDEase domainSMARTSM00471hd_13coord: 54..210
e-value: 1.2E-10
score: 51.4
IPR003607HD/PDEase domainPROSITEPS51831HDcoord: 58..201
score: 12.925
IPR003607HD/PDEase domainCDDcd00077HDccoord: 56..209
e-value: 8.70278E-11
score: 58.1197
NoneNo IPR availableGENE3DG3DSA:1.10.3210.10coord: 10..350
e-value: 4.6E-88
score: 297.8
NoneNo IPR availablePANTHERPTHR11373SAM DOMAIN AND HD DOMAIN-CONTAINING PROTEIN-RELATEDcoord: 11..454
NoneNo IPR availablePANTHERPTHR11373:SF4DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1coord: 11..454
NoneNo IPR availableSUPERFAMILYSSF109604HD-domain/PDEase-likecoord: 11..435
IPR006674HD domainPFAMPF01966HDcoord: 58..202
e-value: 2.6E-12
score: 47.0