Protein canopy-like protein 3

Overview


Name	Protein canopy-like protein 3
Smed ID	SMED30023812
Length (bp)	835

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Protein canopy-like protein 3 (SMED30023812) t-SNE clustered cells

Violin plots show distribution of expression levels for Protein canopy-like protein 3 (SMED30023812) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Protein canopy-like protein 3 (SMED30023812) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Protein canopy-like protein 3 (SMED30023812) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30023812

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 1

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
muscle cell	SMED30023812	SMESG000068798.1	dd_Smed_v4_4234_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of Protein canopy-like protein 3 vs. Ensembl Human
Match: CNPY3 (canopy FGF signaling regulator 3 [Source:HGNC Symbol;Acc:HGNC:11968])

HSP 1 Score: 176.407 bits (446), Expect = 2.030e-53
Identity = 96/184 (52.17%), Postives = 126/184 (68.48%), Query Frame = 2

Query:  137 AEDRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYK-LDNK-NIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEKLSPESKET 679
            AE+   V+L +KCEVCK +A+EL S F+ET K KEV  TGY  LD K + +KY KS+LRL EV E   IC+R+  Y LHKER  S RFAKG+ +TFETL  L  +GV++ MD+P  LW++ +AE + L KQC  +V + EEVIEDWY NHQ++DL +FLC  HVL  +   CL E+ S +  +T
Sbjct:   37 AEENDWVRLPSKCEVCKYVAVELKSAFEETGKTKEVIGTGYGILDQKASGVKYTKSDLRLIEVTET--ICKRLLDYSLHKERTGSNRFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDWYRNHQEEDLTEFLCANHVLKGKDTSCLAEQWSGKKGDT 218

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BLAST of Protein canopy-like protein 3 vs. Ensembl Human
Match: CNPY4 (canopy FGF signaling regulator 4 [Source:HGNC Symbol;Acc:HGNC:28631])

HSP 1 Score: 146.362 bits (368), Expect = 3.703e-42
Identity = 76/175 (43.43%), Postives = 107/175 (61.14%), Query Frame = 2

Query:  140 EDRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYKLDN---KNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNE 652
            ED    +L +KCEVCK+L+ EL +    T + +EV E G  LD    K  + Y  SE RL E +E+  +CER+  Y +H ERK S R+AKG  QT  TLK L  +GV++ + +P  LWD+P+ E + L KQC  M+ + E+++ DWYF+HQ++ L +FLC  HVL      CL E
Sbjct:   27 EDDDTERLPSKCEVCKLLSTELQAELSRTGRSREVLELGQVLDTGKRKRHVPYSVSETRLEEALEN--LCERILDYSVHAERKGSLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTYLKKQCETMLEEFEDIVGDWYFHHQEQPLQNFLCEGHVLPAAETACLQE 199

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BLAST of Protein canopy-like protein 3 vs. Ensembl Human
Match: CNPY4 (canopy FGF signaling regulator 4 [Source:HGNC Symbol;Acc:HGNC:28631])

HSP 1 Score: 90.8929 bits (224), Expect = 2.148e-22
Identity = 50/117 (42.74%), Postives = 70/117 (59.83%), Query Frame = 2

Query:  182 CKILAIELISRFKETDK-KEVYETGYKLDN---KNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQ 520
            CK+L+ EL +    T + +EV E G  LD    K  + Y  SE RL E +E+  +CER+  Y +H ERK S R+AKG  QT  TLK L  +GV++ + +P  LWD+P+ E + L KQ
Sbjct:    2 CKLLSTELQAELSRTGRSREVLELGQVLDTGKRKRHVPYSVSETRLEEALEN--LCERILDYSVHAERKGSLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTYLKKQ 116

[Close]

BLAST of Protein canopy-like protein 3 vs. Ensembl Human
Match: CNPY3 (canopy FGF signaling regulator 3 [Source:HGNC Symbol;Acc:HGNC:11968])

HSP 1 Score: 61.6178 bits (148), Expect = 2.626e-11
Identity = 40/73 (54.79%), Postives = 51/73 (69.86%), Query Frame = 2

Query:  137 AEDRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYK-LDNK-NIIKYEKSELRLTEVIEDPHICERM 346
            AE+   V+L +KCEVCK +A+EL S F+ET K KEV  TGY  LD K + +KY KS+LRL EV E   IC+R+
Sbjct:   37 AEENDWVRLPSKCEVCKYVAVELKSAFEETGKTKEVIGTGYGILDQKASGVKYTKSDLRLIEVTET--ICKRL 107

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BLAST of Protein canopy-like protein 3 vs. Ensembl Celegans
Match: C11H1.7 (pep chromosome:WBcel235:X:14327409:14330195:1 gene:WBGene00007531.1 transcript:C11H1.7a.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C11H1.7)

HSP 1 Score: 88.1965 bits (217), Expect = 3.712e-21
Identity = 43/164 (26.22%), Postives = 89/164 (54.27%), Query Frame = 2

Query:  161 LATKCEVCKILAIELISRFKETDKKEVYETGYKLDNKNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQD-KDLMDFLCVKHVLNNEYNGCLN 649
            + TKCE+C + ++E                    + K++  +++      ++ E+  IC    ++++HKE+    RF++   +T ETLK++  +GV++++ +P  +WDQP+AE  +L + C  ++  +E++IE+W+ N    +DL   LC ++ L N+   C +
Sbjct:   26 MPTKCEICALTSMEF-------------------EAKSVKVHKRLSSEFADITEN--ICNGFNEFKIHKEKTGLERFSRAQSKTIETLKQMREKGVKVELGMPFEMWDQPSAEIFALRQGCESLLEDYEDLIEEWFINKASLEDLFKQLCARNALKNQETSCFD 168

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BLAST of Protein canopy-like protein 3 vs. Ensembl Celegans
Match: C11H1.7 (pep chromosome:WBcel235:X:14327569:14330193:1 gene:WBGene00007531.1 transcript:C11H1.7a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C11H1.7)

HSP 1 Score: 88.1965 bits (217), Expect = 3.712e-21
Identity = 43/164 (26.22%), Postives = 89/164 (54.27%), Query Frame = 2

Query:  161 LATKCEVCKILAIELISRFKETDKKEVYETGYKLDNKNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQD-KDLMDFLCVKHVLNNEYNGCLN 649
            + TKCE+C + ++E                    + K++  +++      ++ E+  IC    ++++HKE+    RF++   +T ETLK++  +GV++++ +P  +WDQP+AE  +L + C  ++  +E++IE+W+ N    +DL   LC ++ L N+   C +
Sbjct:   26 MPTKCEICALTSMEF-------------------EAKSVKVHKRLSSEFADITEN--ICNGFNEFKIHKEKTGLERFSRAQSKTIETLKQMREKGVKVELGMPFEMWDQPSAEIFALRQGCESLLEDYEDLIEEWFINKASLEDLFKQLCARNALKNQETSCFD 168

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BLAST of Protein canopy-like protein 3 vs. Ensembl Celegans
Match: C11H1.7 (pep chromosome:WBcel235:X:14329920:14330135:1 gene:WBGene00007531.1 transcript:C11H1.7b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C11H1.7)

HSP 1 Score: 50.447 bits (119), Expect = 2.091e-8
Identity = 21/63 (33.33%), Postives = 38/63 (60.32%), Query Frame = 2

Query:  464 VPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQD-KDLMDFLCVKHVLNNEYNGCLN 649
            +P  +WDQP+AE  +L + C  ++  +E++IE+W+ N    +DL   LC ++ L N+   C +
Sbjct:    1 MPFEMWDQPSAEIFALRQGCESLLEDYEDLIEEWFINKASLEDLFKQLCARNALKNQETSCFD 63

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BLAST of Protein canopy-like protein 3 vs. Ensembl Fly
Match: CNPYb (gene:FBgn0036847 transcript:FBtr0075034)

HSP 1 Score: 166.007 bits (419), Expect = 2.020e-50
Identity = 88/200 (44.00%), Postives = 126/200 (63.00%), Query Frame = 2

Query:   83 LFSFHSYYVFIECSDNEIAEDRHGVKLATKCEVCKILAIELISRFKETDKK-EVYETGYKLDN---KNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQD-KDLMDFLCVKHVLNNEY-NGCLNEKLSP 664
            L  F + +V ++ +  +  E+  GV+ A +CE CKILA EL +R  ET K  +V E GY +D+   K   +Y +SELRL E +E+  +CER+ +Y LHKER DSTRFAKG+ QTF+TL  L  +GV++ + +P  LWD+P  E + +  QC  ++ ++EE I +WYF HQD K L   LC  HVL  +    CL E+L+P
Sbjct:    6 LPGFVTLWVVLQLAGADSPEEEQGVRYANRCEACKILATELEARLGETGKSHDVIEIGYSVDDVKPKKRTEYRRSELRLLESLEN--VCERVLEYNLHKERSDSTRFAKGMSQTFQTLHGLVDKGVKVDLGIPYELWDKPPVEVTQMKTQCENLLEEYEETISEWYFKHQDEKSLKKHLCEDHVLKKKAERECLKEQLAP 203

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BLAST of Protein canopy-like protein 3 vs. Ensembl Zebrafish
Match: cnpy3 (canopy FGF signaling regulator 3 [Source:NCBI gene;Acc:550136])

HSP 1 Score: 166.392 bits (420), Expect = 8.108e-50
Identity = 92/186 (49.46%), Postives = 121/186 (65.05%), Query Frame = 2

Query:  143 DRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYK-LDNKNI--IKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEKLSPESKETDFA 688
            D   V L  KCEVCK ++IE+ S F ET K KEV +T Y+ LD+K    IKY KS++R  EV E  ++C R+ QY LHKER  S RFAKG+ +TF TL  L  +GV++ MD+P  LW++ +AE + L KQC  MV Q+E+VIEDWY   Q++DL  +LC KHVL  +  GCL E  +   K+ D A
Sbjct:   22 DDEWVHLPNKCEVCKFVSIEMKSAFDETGKTKEVIDTNYRFLDDKGAPPIKYVKSDIRFIEVTE--NVCSRIMQYNLHKERDGSNRFAKGMSETFSTLHNLVNKGVKVVMDIPYELWNETSAEVADLKKQCDVMVEQYEDVIEDWYKGSQEEDLTTYLCEKHVLKGQDTGCLKETWA--GKKGDMA 203

[Close]

Query:  143 DRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYK-LDNKNI--IKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEKLSPESKETDFA 688
            D   V L  KCEVCK ++IE+ S F ET K KEV +T Y+ LD+K    IKY KS++R  EV E  ++C R+ QY LHKER  S RFAKG+ +TF TL  L  +GV++ MD+P  LW++ +AE + L KQC  MV Q+E+VIEDWY   Q++DL  +LC KHVL  +  GCL E  +   K+ D A
Sbjct:   22 DDEWVHLPNKCEVCKFVSIEMKSAFDETGKTKEVIDTNYRFLDDKGAPPIKYVKSDIRFIEVTE--NVCSRIMQYNLHKERDGSNRFAKGMSETFSTLHNLVNKGVKVVMDIPYELWNETSAEVADLKKQCDVMVEQYEDVIEDWYKGSQEEDLTTYLCEKHVLKGQDTGCLKETWA--GKKGDMA 203

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BLAST of Protein canopy-like protein 3 vs. Ensembl Zebrafish
Match: cnpy4 (canopy FGF signaling regulator 4 [Source:NCBI gene;Acc:568776])

HSP 1 Score: 163.696 bits (413), Expect = 2.063e-49
Identity = 89/194 (45.88%), Postives = 121/194 (62.37%), Query Frame = 2

Query:   83 LFSFHSYYVFIECSDNEIAEDRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYKLDN---KNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNE 652
            +F+   +Y+F     N+  E+R    L  KCEVCK+L +EL     +T + KEV E G  LD    +  IKY  SE+RLTE +++  ICER+ QY++H ER  S R+AKG  QT  TLK L  +GV++++ VP  LWD+PT E + L +QC  M+ +HEEV+EDWYF+HQDK L  F C  HVL +    CL E
Sbjct:    3 MFTVFLFYMFSLVLANQ--EER----LPNKCEVCKLLTVELQDALDKTGRSKEVVELGEVLDTGKRRRKIKYNTSEMRLTEAMDN--ICERILQYKVHAERPGSLRYAKGTSQTMNTLKNLVEKGVKVELGVPYELWDEPTVEVAELKRQCETMLEEHEEVVEDWYFHHQDKGLERFFCEAHVLKDSDQECLTE 188

[Close]

Query:   83 LFSFHSYYVFIECSDNEIAEDRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYKLDN---KNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNE 652
            +F+   +Y+F     N+  E+R    L  KCEVCK+L +EL     +T + KEV E G  LD    +  IKY  SE+RLTE +++  ICER+ QY++H ER  S R+AKG  QT  TLK L  +GV++++ VP  LWD+PT E + L +QC  M+ +HEEV+EDWYF+HQDK L  F C  HVL +    CL E
Sbjct:    3 MFTVFLFYMFSLVLANQ--EER----LPNKCEVCKLLTVELQDALDKTGRSKEVVELGEVLDTGKRRRKIKYNTSEMRLTEAMDN--ICERILQYKVHAERPGSLRYAKGTSQTMNTLKNLVEKGVKVELGVPYELWDEPTVEVAELKRQCETMLEEHEEVVEDWYFHHQDKGLERFFCEAHVLKDSDQECLTE 188

[Close]

BLAST of Protein canopy-like protein 3 vs. Ensembl Zebrafish
Match: cnpy4 (canopy FGF signaling regulator 4 [Source:NCBI gene;Acc:568776])

HSP 1 Score: 125.946 bits (315), Expect = 4.118e-36
Identity = 57/110 (51.82%), Postives = 78/110 (70.91%), Query Frame = 2

Query:  299 LRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNN 628
            +RLTE +++  ICER+ QY++H ER  S R+AKG  QT  TLK L  +GV++++ VP  LWD+PT E + L +QC  M+ +HEEV+EDWYF+HQDK L  F C  HVL +
Sbjct:    1 MRLTEAMDN--ICERILQYKVHAERPGSLRYAKGTSQTMNTLKNLVEKGVKVELGVPYELWDEPTVEVAELKRQCETMLEEHEEVVEDWYFHHQDKGLERFFCEAHVLKD 108

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BLAST of Protein canopy-like protein 3 vs. Ensembl Mouse
Match: Cnpy3 (canopy FGF signaling regulator 3 [Source:MGI Symbol;Acc:MGI:1919279])

HSP 1 Score: 177.563 bits (449), Expect = 4.115e-54
Identity = 98/187 (52.41%), Postives = 127/187 (67.91%), Query Frame = 2

Query:  137 AEDRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYK-LDNKNI-IKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEKLSPESKETDFA 688
            AE+   V+L +KCEVCK +A+EL S F+ET K KEV +TGY  LD K   +KY KS+LRL EV E   IC+R+  Y LHKER  S RFAKG+ +TFETL  L  +GV++ MD+P  LW++ +AE + L KQC  +V + EEVIEDWY NHQ++DL +FLC  HVL  +   CL E+ S   K+ D A
Sbjct:   37 AEETDWVRLPSKCEVCKYVAVELKSAFEETGKTKEVIDTGYGILDGKGSGVKYTKSDLRLIEVTET--ICKRLLDYSLHKERTGSNRFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDWYRNHQEEDLTEFLCANHVLKGKDTSCLAERWS--GKKGDIA 219

[Close]

BLAST of Protein canopy-like protein 3 vs. Ensembl Mouse
Match: Cnpy4 (canopy FGF signaling regulator 4 [Source:MGI Symbol;Acc:MGI:1913705])

HSP 1 Score: 151.369 bits (381), Expect = 2.600e-44
Identity = 82/209 (39.23%), Postives = 122/209 (58.37%), Query Frame = 2

Query:   68 KFVLILFSFHSYYVFIECSDNEIAEDRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYKLDN---KNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEKLSPESKETD 682
            +  ++LF   +Y  + E +  E  +     +L +KCEVCK+L++EL      T + +EV E G  LD    K  + Y  SE RL E +E+  +CER+  Y +H ERK S R+AKG  QT  TLK L  +GV++ + +P  LWD+P+ E + L KQC  M+ + E+V+ DWYF+HQ++ L  FLC +HVL      CL E  + + K +D
Sbjct:   12 RLEILLFILAAYGAWAEATKEEEDDTE---RLPSKCEVCKLLSMELQEALSRTGRSREVLELGQVLDTGKRKRHVPYSLSETRLEEALEN--LCERILDYNVHAERKGSLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTFLKKQCETMLEEFEDVVGDWYFHHQEQPLQHFLCERHVLPASETACLREAWTGKEKISD 215

[Close]

BLAST of Protein canopy-like protein 3 vs. Ensembl Mouse
Match: Cnpy4 (canopy FGF signaling regulator 4 [Source:MGI Symbol;Acc:MGI:1913705])

HSP 1 Score: 100.908 bits (250), Expect = 7.845e-26
Identity = 55/130 (42.31%), Postives = 79/130 (60.77%), Query Frame = 2

Query:  179 VCKILAIELISRFKETDK-KEVYETGYKLDN---KNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVI 556
            VCK+L++EL      T + +EV E G  LD    K  + Y  SE RL E +E+  +CER+  Y +H ERK S R+AKG  QT  TLK L  +GV++ + +P  LWD+P+ E + L KQC  M+ + E+V+
Sbjct:   33 VCKLLSMELQEALSRTGRSREVLELGQVLDTGKRKRHVPYSLSETRLEEALEN--LCERILDYNVHAERKGSLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTFLKKQCETMLEEFEDVV 160

[Close]

BLAST of Protein canopy-like protein 3 vs. Ensembl Mouse
Match: Cnpy3 (canopy FGF signaling regulator 3 [Source:MGI Symbol;Acc:MGI:1919279])

HSP 1 Score: 59.3066 bits (142), Expect = 7.274e-11
Identity = 36/67 (53.73%), Postives = 47/67 (70.15%), Query Frame = 2

Query:  137 AEDRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYK-LDNKNI-IKYEKSELRLTEVIEDP 328
            AE+   V+L +KCEVCK +A+EL S F+ET K KEV +TGY  LD K   +KY KS++R T V+ DP
Sbjct:   37 AEETDWVRLPSKCEVCKYVAVELKSAFEETGKTKEVIDTGYGILDGKGSGVKYTKSKVRPTGVLMDP 103

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BLAST of Protein canopy-like protein 3 vs. UniProt/SwissProt
Match: sp|Q9DAU1|CNPY3_MOUSE (Protein canopy homolog 3 OS=Mus musculus OX=10090 GN=Cnpy3 PE=1 SV=1)

HSP 1 Score: 177.563 bits (449), Expect = 2.878e-53
Identity = 98/187 (52.41%), Postives = 127/187 (67.91%), Query Frame = 2

Query:  137 AEDRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYK-LDNKNI-IKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEKLSPESKETDFA 688
            AE+   V+L +KCEVCK +A+EL S F+ET K KEV +TGY  LD K   +KY KS+LRL EV E   IC+R+  Y LHKER  S RFAKG+ +TFETL  L  +GV++ MD+P  LW++ +AE + L KQC  +V + EEVIEDWY NHQ++DL +FLC  HVL  +   CL E+ S   K+ D A
Sbjct:   37 AEETDWVRLPSKCEVCKYVAVELKSAFEETGKTKEVIDTGYGILDGKGSGVKYTKSDLRLIEVTET--ICKRLLDYSLHKERTGSNRFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDWYRNHQEEDLTEFLCANHVLKGKDTSCLAERWS--GKKGDIA 219

[Close]

BLAST of Protein canopy-like protein 3 vs. UniProt/SwissProt
Match: sp|Q0P5N1|CNPY3_BOVIN (Protein canopy homolog 3 OS=Bos taurus OX=9913 GN=CNPY3 PE=2 SV=1)

HSP 1 Score: 177.178 bits (448), Expect = 5.023e-53
Identity = 97/184 (52.72%), Postives = 126/184 (68.48%), Query Frame = 2

Query:  137 AEDRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYK-LDNK-NIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEKLSPESKET 679
            AED   V+L +KCEVCK +A+EL S F+ET K KEV +TGY  LD K + +KY KS+LRL EV E   IC+R+  Y LHKER  S RFAKG+ +TFETL  L  +GV++ MD+P  LW++ +AE + L KQC  +V + EEVIEDWY NHQ++DL  FLC  HVL  +   CL E+ S +  +T
Sbjct:   43 AEDTDWVRLPSKCEVCKYVAVELKSAFEETGKTKEVIDTGYGILDRKASGVKYTKSDLRLIEVTET--ICKRLLDYSLHKERTGSNRFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDWYRNHQEEDLTQFLCANHVLKGKDASCLAEQWSGKKGDT 224

[Close]

BLAST of Protein canopy-like protein 3 vs. UniProt/SwissProt
Match: sp|Q9BT09|CNPY3_HUMAN (Protein canopy homolog 3 OS=Homo sapiens OX=9606 GN=CNPY3 PE=1 SV=1)

HSP 1 Score: 176.407 bits (446), Expect = 9.748e-53
Identity = 96/184 (52.17%), Postives = 126/184 (68.48%), Query Frame = 2

Query:  137 AEDRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYK-LDNK-NIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEKLSPESKET 679
            AE+   V+L +KCEVCK +A+EL S F+ET K KEV  TGY  LD K + +KY KS+LRL EV E   IC+R+  Y LHKER  S RFAKG+ +TFETL  L  +GV++ MD+P  LW++ +AE + L KQC  +V + EEVIEDWY NHQ++DL +FLC  HVL  +   CL E+ S +  +T
Sbjct:   37 AEENDWVRLPSKCEVCKYVAVELKSAFEETGKTKEVIGTGYGILDQKASGVKYTKSDLRLIEVTET--ICKRLLDYSLHKERTGSNRFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDWYRNHQEEDLTEFLCANHVLKGKDTSCLAEQWSGKKGDT 218

[Close]

BLAST of Protein canopy-like protein 3 vs. UniProt/SwissProt
Match: sp|A5GFQ5|CNPY3_PIG (Protein canopy homolog 3 OS=Sus scrofa OX=9823 GN=CNPY3 PE=3 SV=1)

HSP 1 Score: 176.022 bits (445), Expect = 1.516e-52
Identity = 96/184 (52.17%), Postives = 126/184 (68.48%), Query Frame = 2

Query:  137 AEDRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYK-LDNK-NIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEKLSPESKET 679
            AE+   V+L +KCEVCK +A+EL S F+ET K KEV +TGY  LD K + +KY KS+LRL EV E   IC+R+  Y LHKER  S RFAKG+ +TFETL  L  +GV++ MD+P  LW++ +AE + L KQC  +V + EEVIEDWY NHQ++DL  FLC  HVL  +   CL E+ S +  +T
Sbjct:   45 AEETDWVRLPSKCEVCKYVAVELKSAFEETGKTKEVIDTGYGILDRKASGVKYTKSDLRLIEVTET--ICKRLLDYSLHKERTGSNRFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVLVEEFEEVIEDWYRNHQEEDLTQFLCANHVLKGKDTSCLAEQWSGKKGDT 226

[Close]

BLAST of Protein canopy-like protein 3 vs. UniProt/SwissProt
Match: sp|A3KNS2|CNPY3_DANRE (Protein canopy homolog 3 OS=Danio rerio OX=7955 GN=cnpy3 PE=2 SV=1)

HSP 1 Score: 166.392 bits (420), Expect = 5.926e-49
Identity = 92/186 (49.46%), Postives = 121/186 (65.05%), Query Frame = 2

Query:  143 DRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYK-LDNKNI--IKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEKLSPESKETDFA 688
            D   V L  KCEVCK ++IE+ S F ET K KEV +T Y+ LD+K    IKY KS++R  EV E  ++C R+ QY LHKER  S RFAKG+ +TF TL  L  +GV++ MD+P  LW++ +AE + L KQC  MV Q+E+VIEDWY   Q++DL  +LC KHVL  +  GCL E  +   K+ D A
Sbjct:   22 DDEWVHLPNKCEVCKFVSIEMKSAFDETGKTKEVIDTNYRFLDDKGAPPIKYVKSDIRFIEVTE--NVCSRIMQYNLHKERDGSNRFAKGMSETFSTLHNLVNKGVKVVMDIPYELWNETSAEVADLKKQCDVMVEQYEDVIEDWYKGSQEEDLTTYLCEKHVLKGQDTGCLKETWA--GKKGDMA 203

[Close]

BLAST of Protein canopy-like protein 3 vs. TrEMBL
Match: G4VQL9 (Ctg4a-related OS=Schistosoma mansoni OX=6183 GN=Smp_060190.3 PE=4 SV=1)

HSP 1 Score: 192.971 bits (489), Expect = 1.079e-57
Identity = 89/195 (45.64%), Postives = 136/195 (69.74%), Query Frame = 2

Query:   71 FVLILFSFHSYYVFIECSDNEIAEDRHGVKLATKCEVCKILAIELISRFKETDKKEVYETGYKLDNKNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEK 655
             +L LFS   +  F+     EI  D   V L +KCEVCK+L  E++SR +ET   +         +   +KYE SELRL EV+EDP IC R+ QY++HKER+DS+RF KG PQT ++L +L  RGV++K+DVP  LWD+P+ E ++L+K+C+P+V++++++IE+W++++QD +L D+LC ++VL+    GCLNEK
Sbjct:    1 MILHLFSLLVFLTFVR---GEIVND---VILPSKCEVCKLLVTEILSRLQETKSSDALNVRSVQGDSKKVKYETSELRLYEVLEDPPICSRLLQYKVHKERQDSSRFDKGTPQTMKSLTELVNRGVDVKLDVPFELWDKPSVEVTTLFKECIPLVNEYQDIIEEWFYSNQDINLYDYLCRENVLDKSSQGCLNEK 189

[Close]

BLAST of Protein canopy-like protein 3 vs. TrEMBL
Match: A0A4Z2DCJ7 (Protein canopy 4 isoform 1 OS=Schistosoma japonicum OX=6182 GN=EWB00_002446 PE=4 SV=1)

HSP 1 Score: 190.66 bits (483), Expect = 8.573e-57
Identity = 86/192 (44.79%), Postives = 137/192 (71.35%), Query Frame = 2

Query:   80 ILFSFHSYYVFIECSDNEIAEDRHGVKLATKCEVCKILAIELISRFKETDKKEVYETGYKLDNKNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEK 655
            +L    S  +F+    +++  D   V L +KCEVCK+L  E++SR +ET   +         +   +KY+ SELRL EV+EDP IC R+ QY++HKER+DSTRF K +PQT ++L +L  RGV++K+DVP  LWD+P+AE ++L+KQC+P+V++++E+IE+W++N+Q+++L D+LC ++VL+    GCL+EK
Sbjct:    1 MLLGSISILIFLLLVKSDMMTD---VVLPSKCEVCKLLVTEILSRLQETKSSDALNLHSFQGDPMKLKYDTSELRLYEVLEDPPICNRLLQYKVHKERQDSTRFDKSMPQTMKSLSELVNRGVDVKLDVPFELWDKPSAEVTTLFKQCIPLVNEYQEIIEEWFYNNQNRNLYDYLCRENVLDESSQGCLDEK 189

[Close]

BLAST of Protein canopy-like protein 3 vs. TrEMBL
Match: K1QUP8 (Canopy-like protein 3 OS=Crassostrea gigas OX=29159 GN=CGI_10025608 PE=4 SV=1)

HSP 1 Score: 188.734 bits (478), Expect = 1.263e-55
Identity = 95/206 (46.12%), Postives = 126/206 (61.17%), Query Frame = 2

Query:   59 FIFKFVLILFSFHSYYVFIECSDNEIAEDRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYKLDNKNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEKLSPESK 673
            F F  VL+L       V I C+D     D  GV L + CEVCK    EL SR  ET K KE  + G+ LD K  I Y KSELRLTE + DPH+C+++ +Y +HKER  S RFAKG  +T ETL  L  +GV++++ +P  LWD P+AE + + ++C  M  ++E+ IEDWYFNHQ+KDLM +LC    L  +   CL EK  P+ K
Sbjct:    6 FGFTLVLLL-----NVVGINCND-----DDSGVILPSMCEVCKFFVTELQSRLDETGKTKETLQVGHGLDKKKKIVYHKSELRLTEALTDPHVCDKILEYNVHKERSGSNRFAKGRSETMETLHGLVNKGVKVELGIPHELWDAPSAEVTDMQRKCFKMAEEYEDEIEDWYFNHQEKDLMTYLCANRALRKDDKKCLTEKYEPKGK 201

[Close]

BLAST of Protein canopy-like protein 3 vs. TrEMBL
Match: A0A5E4PUU8 (DUF3456 domain-containing protein OS=Leptidea sinapis OX=189913 GN=LSINAPIS_LOCUS1973 PE=4 SV=1)

HSP 1 Score: 187.578 bits (475), Expect = 2.074e-55
Identity = 97/206 (47.09%), Postives = 138/206 (66.99%), Query Frame = 2

Query:   71 FVLILFSFHSYYVFIECSDNEI-AEDRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYKLDN---KNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDK-DLMDFLCVKHVLNNEYNGCLNEKLSPES 670
             +L +F F  Y VF+  +D E+  E+  GVK A +CEVCKILA EL +R +ET K  ++ E GY LD+   K   KYEKSELRL E ++   +CE++ +Y +HKER+DSTRFAKG+ QTF+TL  L  +GV++ + +P  LWD+P+AE + +  QC  ++ ++EE IEDWY+ HQ   DL ++LCVKH L N  + CL E+L  + 
Sbjct:    1 MILKIFMFVMYLVFVASNDVEVKTEEDLGVKYANRCEVCKILATELQTRLEETGKVHDILEIGYSLDDVQPKKRTKYEKSELRLIESLDG--VCEKILEYNIHKERQDSTRFAKGMSQTFQTLHGLVDKGVKVDLGIPYELWDKPSAEITQMKSQCESLLEENEEAIEDWYWKHQGSIDLKNYLCVKHALRNTDDSCLYEELQSKG 204

[Close]

BLAST of Protein canopy-like protein 3 vs. TrEMBL
Match: A0A0V0J325 (DUF3456 domain-containing protein OS=Schistocephalus solidus OX=70667 GN=TR88674 PE=4 SV=1)

HSP 1 Score: 187.578 bits (475), Expect = 5.789e-55
Identity = 90/178 (50.56%), Postives = 122/178 (68.54%), Query Frame = 2

Query:  140 EDRHGVKLATKCEVCKILAIELISRFKETDKKEVYETGYKLDNKNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMD-FLCVKHVLNNEYNGCLNEKLSPES 670
            ED +GVK  T CEVCKI A E + RFKET    +    Y  ++   + Y  SELRLTE++++P +C+RM QY++HKER DSTRF K +PQTFE LK+L  RGV++K DVP  LWD P+AE + L K C+ ++ ++EEVIEDW+++HQ ++  D FLC KH+L    + CL E L P S
Sbjct:   32 EDDYGVKPPTACEVCKIFANEFMDRFKETSSFGLINIDYGAEDGRQLPYATSELRLTEILQEPSLCDRMLQYRVHKERTDSTRFEKRVPQTFEVLKELLDRGVDVKTDVPYQLWDSPSAEITLLQKSCLIILEEYEEVIEDWFYHHQLEEPFDIFLCSKHMLKGLPSDCLKETLPPPS 209

[Close]

BLAST of Protein canopy-like protein 3 vs. Ensembl Cavefish
Match: cnpy3 (canopy FGF signaling regulator 3 [Source:NCBI gene;Acc:103043697])

HSP 1 Score: 163.31 bits (412), Expect = 9.702e-49
Identity = 92/186 (49.46%), Postives = 121/186 (65.05%), Query Frame = 2

Query:  107 VFIECSDNEIAEDRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYK-LDNKNI--IKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNE 652
            VF+  S+ E  E  H   L  KCEVCK ++IE+ S  +ET K KEV ET Y+ LD+K    IKY KS++R  EVIE   +C R+  Y LHKER  S RFAKG+ +TF TL  L  +GV++ MD+P  LW++ +AE + L KQC  M+ Q+EEVIEDWY  +Q++DL  +LC KHVL  +   CL E
Sbjct:   10 VFVGVSEGEEDEWVH---LPNKCEVCKFVSIEMKSALEETGKTKEVIETNYRFLDDKGAPPIKYVKSDIRFIEVIE--SVCSRILSYNLHKERDGSNRFAKGMSETFSTLHNLVHKGVKVVMDIPYELWNETSAEVADLKKQCDVMIEQYEEVIEDWYKGNQEEDLTTYLCGKHVLKGQDQECLKE 190

[Close]

BLAST of Protein canopy-like protein 3 vs. Ensembl Cavefish
Match: cnpy4 (canopy FGF signaling regulator 4 [Source:NCBI gene;Acc:103047252])

HSP 1 Score: 155.606 bits (392), Expect = 5.468e-46
Identity = 80/169 (47.34%), Postives = 108/169 (63.91%), Query Frame = 2

Query:  158 KLATKCEVCKILAIELISRFKETDK-KEVYETGYKLDN---KNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNE 652
            +L  KCEVCK L +EL +  ++T + KEV E G  LD    +  IKY  SE RLTE +++  IC  + QY +H ER  S R+AKG  QT  TLK L  +GV++++ +P  LWD+PT E + L +QC  M+ ++EEV+EDWYFNHQ++ L  FLC  HVL N    CL E
Sbjct:   49 RLPKKCEVCKFLTVELQAALEKTGRSKEVMELGEVLDTGKRRRKIKYNTSETRLTEAVDN--ICAGILQYNVHAERPGSLRYAKGASQTMSTLKNLVDKGVKVELGIPYELWDEPTVEVADLKRQCETMLEEYEEVVEDWYFNHQEQRLEKFLCETHVLKNSDMECLKE 215

[Close]

BLAST of Protein canopy-like protein 3 vs. Ensembl Nematostella
Match: EDO37294 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SG92])

HSP 1 Score: 107.071 bits (266), Expect = 6.351e-28
Identity = 67/168 (39.88%), Postives = 97/168 (57.74%), Query Frame = 2

Query:  167 TKCEVCKILAIELISRFKETDKKEVYETGYKLD----NKNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDST-RFAKGIPQTF-ETLKKLSARG-VEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLN 649
            TKC+VC+++  EL+ R K T+ KE    GY LD     +  I Y  SELRL +V++D  +C+R+   +L++ R      + KG      E +  L+AR  V +K  VP+ + +  T E   +  QCV M+   EEVIE+WYF HQD+DLM +LC + VL  +  GCLN
Sbjct:   47 TKCQVCRLMVSELLERLKITNYKETLNKGYGLDLGEDPRLQIHYHTSELRLADVLDD--LCDRV---KLYRARAGPAFPYIKGAKSHLREAMDDLAARSKVGLKFHVPDDVIEDYTYEVVRMKFQCVHMLELFEEVIEEWYFEHQDQDLMTWLCRERVLKIDEQGCLN 209

[Close]

BLAST of Protein canopy-like protein 3 vs. Ensembl Nematostella
Match: EDO35469 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLC4])

HSP 1 Score: 111.694 bits (278), Expect = 1.022e-27
Identity = 51/117 (43.59%), Postives = 77/117 (65.81%), Query Frame = 2

Query:  278 IKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNN 628
            I Y KSELRLTE +E+   C  +  Y++HK++  + R+ K    TF+TLK L  RGV++ +  P+ +WD P AE + L  +C  MV QHE+ I +WY+NH D++L  +LC++ VLN+
Sbjct:   28 INYRKSELRLTEALEEA--CSNVLDYKVHKDKPLAQRYEKVESVTFKTLKGLKKRGVKVDLGFPDQMWDTPDAEVTRLKNRCEYMVEQHEDDITEWYWNHPDENLTQWLCIERVLNS 142

[Close]

BLAST of Protein canopy-like protein 3 vs. Ensembl Nematostella
Match: EDO37273 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SG93])

HSP 1 Score: 48.9062 bits (115), Expect = 4.533e-7
Identity = 24/66 (36.36%), Postives = 32/66 (48.48%), Query Frame = 2

Query:  464 VPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEKLS 661
             PE   D PT E   L K+C  M+   + ++  W+   Q +DL  +LC   VL  E   CLN  LS
Sbjct:  129 TPEENLDDPTGEIRRLEKKCKKMLVAEQHMLVHWFMKEQSRDLTTWLCANRVLIGEDQDCLNVDLS 194

[Close]

BLAST of Protein canopy-like protein 3 vs. Ensembl Medaka
Match: cnpy3 (protein canopy homolog 3-like [Source:NCBI gene;Acc:101158057])

HSP 1 Score: 167.548 bits (423), Expect = 3.658e-50
Identity = 89/181 (49.17%), Postives = 120/181 (66.30%), Query Frame = 2

Query:  143 DRHGVKLATKCEVCKILAIELISRFKETDK-KEVYETGYK-LDNKNI--IKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEKLSPESK 673
            D   V L  KCEVCK ++IE+ S F+ET K KEV ++ Y  +D K    IKY KS+LR  EV+E  ++C+R+ +Y LHKER  S RFAKG+ +TF TL  L  +GV++ MD+P  LW++ +AE + L KQC  M+ Q+EEVIEDWY   Q++DL  FLC KHVL  +   CLNE  + + K
Sbjct:   25 DDEWVHLPNKCEVCKFVSIEMKSAFQETGKTKEVIDSKYNFIDGKGAPPIKYVKSDLRFIEVVE--NVCQRLLEYNLHKERSGSNRFAKGMSETFSTLHGLVNKGVKVVMDIPYELWNETSAEVADLKKQCDVMIEQYEEVIEDWYKGSQEEDLTTFLCEKHVLKGQDKDCLNENWTAKKK 203

[Close]

BLAST of Protein canopy-like protein 3 vs. Ensembl Medaka
Match: cnpy2 (protein canopy homolog 2 [Source:NCBI gene;Acc:101175475])

HSP 1 Score: 48.1358 bits (113), Expect = 1.861e-6
Identity = 58/201 (28.86%), Postives = 92/201 (45.77%), Query Frame = 2

Query:   74 VLILFSFHSYYVFIECSDNEIAEDRHGVKLATKCEVCKILAIELISRFKETDKKEVYETG-YKL--DNKNIIK---YEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHE-EVIEDWYFNHQDKDLMDFLCVK------HVLNNEYN 637
             L+L S     +F+ CS       R G  +  KC  C+ L  E+     + D K+  +TG +++  D    I+     +SE  L E++E   +CERM  Y    ER D       +    ++  ++ +R  E  MD+ E+  D     TSSL   C  +V  HE E+IE  +F H+ +++ D LC K      H LN  ++
Sbjct:    6 ALLLTSCVVVGLFLSCSQAA----RQGQDI--KCGACRALVDEMEWAISQIDPKKTIQTGSFRINPDGSQSIREVPLARSEGNLLELMES--VCERMEDY---GERTD-------LSTDRKSYIRVKSRTGE-AMDLSEATLDSRV--TSSLKFACETIVEHHEDEIIE--FFAHETENVKDKLCSKRTDLCDHALNMAHD 183

[Close]

BLAST of Protein canopy-like protein 3 vs. Planmine SMEST
Match: SMESG000068798.1 (SMESG000068798.1)

HSP 1 Score: 442.58 bits (1137), Expect = 1.886e-159
Identity = 213/215 (99.07%), Postives = 214/215 (99.53%), Query Frame = 2

Query:   38 LMKYSGNFIFKFVLILFSFHSYYVFIECSDNEIAEDRHGVKLATKCEVCKILAIELISRFKETDKKEVYETGYKLDNKNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEKLSPESKETD 682
            + KYSGNFIFKFVLILFSFHSYYVFIECSDNEIAEDRHGVKLATKCEVCKILAIELISRFKETDKKEVYETGYKLDNKNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEKLSPESKETD
Sbjct:    1 MHKYSGNFIFKFVLILFSFHSYYVFIECSDNEIAEDRHGVKLATKCEVCKILAIELISRFKETDKKEVYETGYKLDNKNIIKYEKSELRLTEVIEDPHICERMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQPTAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNGCLNEKLSPESKETD 215

The following BLAST results are available for this feature:

BLAST of Protein canopy-like protein 3 vs. Ensembl Human
BLAST of Protein canopy-like protein 3 vs. Ensembl Celegans
BLAST of Protein canopy-like protein 3 vs. Ensembl Fly
BLAST of Protein canopy-like protein 3 vs. Ensembl Zebrafish
BLAST of Protein canopy-like protein 3 vs. Ensembl Xenopus
BLAST of Protein canopy-like protein 3 vs. Ensembl Mouse
BLAST of Protein canopy-like protein 3 vs. UniProt/SwissProt
BLAST of Protein canopy-like protein 3 vs. TrEMBL
BLAST of Protein canopy-like protein 3 vs. Ensembl Cavefish
BLAST of Protein canopy-like protein 3 vs. Ensembl Sea Lamprey
BLAST of Protein canopy-like protein 3 vs. Ensembl Yeast
BLAST of Protein canopy-like protein 3 vs. Ensembl Nematostella
BLAST of Protein canopy-like protein 3 vs. Ensembl Medaka
BLAST of Protein canopy-like protein 3 vs. Planmine SMEST

BLAST of Protein canopy-like protein 3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4


Match Name	E-value	Identity	Description
CNPY3	2.030e-53	52.17	canopy FGF signaling regulator 3 [Source:HGNC Symb...	[more]
CNPY4	3.703e-42	43.43	canopy FGF signaling regulator 4 [Source:HGNC Symb...	[more]
CNPY4	2.148e-22	42.74	canopy FGF signaling regulator 4 [Source:HGNC Symb...	[more]
CNPY3	2.626e-11	54.79	canopy FGF signaling regulator 3 [Source:HGNC Symb...	[more]

BLAST of Protein canopy-like protein 3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3


Match Name	E-value	Identity	Description
C11H1.7	3.712e-21	26.22	pep chromosome:WBcel235:X:14327409:14330195:1 gene...	[more]
C11H1.7	3.712e-21	26.22	pep chromosome:WBcel235:X:14327569:14330193:1 gene...	[more]
C11H1.7	2.091e-8	33.33	pep chromosome:WBcel235:X:14329920:14330135:1 gene...	[more]

BLAST of Protein canopy-like protein 3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1


Match Name	E-value	Identity	Description
CNPYb	2.020e-50	44.00	gene:FBgn0036847 transcript:FBtr0075034	[more]

BLAST of Protein canopy-like protein 3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cnpy3	8.108e-50	49.46	canopy FGF signaling regulator 3 [Source:NCBI gene...	[more]
cnpy3	8.108e-50	49.46	canopy FGF signaling regulator 3 [Source:NCBI gene...	[more]
cnpy4	2.063e-49	45.88	canopy FGF signaling regulator 4 [Source:NCBI gene...	[more]
cnpy4	2.063e-49	45.88	canopy FGF signaling regulator 4 [Source:NCBI gene...	[more]
cnpy4	4.118e-36	51.82	canopy FGF signaling regulator 4 [Source:NCBI gene...	[more]

BLAST of Protein canopy-like protein 3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Protein canopy-like protein 3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Cnpy3	4.115e-54	52.41	canopy FGF signaling regulator 3 [Source:MGI Symbo...	[more]
Cnpy4	2.600e-44	39.23	canopy FGF signaling regulator 4 [Source:MGI Symbo...	[more]
Cnpy4	7.845e-26	42.31	canopy FGF signaling regulator 4 [Source:MGI Symbo...	[more]
Cnpy3	7.274e-11	53.73	canopy FGF signaling regulator 3 [Source:MGI Symbo...	[more]

BLAST of Protein canopy-like protein 3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9DAU1\|CNPY3_MOUSE	2.878e-53	52.41	Protein canopy homolog 3 OS=Mus musculus OX=10090 ...	[more]
sp\|Q0P5N1\|CNPY3_BOVIN	5.023e-53	52.72	Protein canopy homolog 3 OS=Bos taurus OX=9913 GN=...	[more]
sp\|Q9BT09\|CNPY3_HUMAN	9.748e-53	52.17	Protein canopy homolog 3 OS=Homo sapiens OX=9606 G...	[more]
sp\|A5GFQ5\|CNPY3_PIG	1.516e-52	52.17	Protein canopy homolog 3 OS=Sus scrofa OX=9823 GN=...	[more]
sp\|A3KNS2\|CNPY3_DANRE	5.926e-49	49.46	Protein canopy homolog 3 OS=Danio rerio OX=7955 GN...	[more]

BLAST of Protein canopy-like protein 3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
G4VQL9	1.079e-57	45.64	Ctg4a-related OS=Schistosoma mansoni OX=6183 GN=Sm...	[more]
A0A4Z2DCJ7	8.573e-57	44.79	Protein canopy 4 isoform 1 OS=Schistosoma japonicu...	[more]
K1QUP8	1.263e-55	46.12	Canopy-like protein 3 OS=Crassostrea gigas OX=2915...	[more]
A0A5E4PUU8	2.074e-55	47.09	DUF3456 domain-containing protein OS=Leptidea sina...	[more]
A0A0V0J325	5.789e-55	50.56	DUF3456 domain-containing protein OS=Schistocephal...	[more]

BLAST of Protein canopy-like protein 3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
cnpy3	9.702e-49	49.46	canopy FGF signaling regulator 3 [Source:NCBI gene...	[more]
cnpy4	5.468e-46	47.34	canopy FGF signaling regulator 4 [Source:NCBI gene...	[more]

BLAST of Protein canopy-like protein 3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Protein canopy-like protein 3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Protein canopy-like protein 3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3


Match Name	E-value	Identity	Description
EDO37294	6.351e-28	39.88	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35469	1.022e-27	43.59	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37273	4.533e-7	36.36	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Protein canopy-like protein 3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
cnpy3	3.658e-50	49.17	protein canopy homolog 3-like [Source:NCBI gene;Ac...	[more]
cnpy2	1.861e-6	28.86	protein canopy homolog 2 [Source:NCBI gene;Acc:101...	[more]

BLAST of Protein canopy-like protein 3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000068798.1	1.886e-159	99.07	SMESG000068798.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30023812 ID=SMED30023812|Name=Protein canopy-like protein 3|organism=Schmidtea mediterranea sexual|type=transcript|length=835bp
GTATCTTACACTTTTGGCGCATCGCAGTACTTAAATTTTAATGAAGTATT
CTGGAAATTTTATTTTCAAATTCGTTCTAATTTTATTCTCATTTCATTCT
TATTATGTTTTCATCGAATGTTCAGATAATGAAATAGCTGAAGATCGACA
TGGGGTGAAACTTGCAACCAAATGCGAAGTGTGTAAGATATTAGCAATTG
AGTTAATATCTCGCTTTAAGGAAACAGATAAGAAGGAAGTTTATGAAACT
GGTTACAAATTGGATAACAAAAATATCATTAAATATGAAAAATCAGAATT
ACGGTTGACGGAAGTGATTGAAGATCCCCATATTTGTGAAAGAATGTGGC
AATACCAATTACACAAAGAAAGAAAAGATAGTACTAGATTCGCCAAAGGA
ATACCTCAAACATTTGAAACTCTAAAAAAATTAAGTGCCCGTGGAGTAGA
AATCAAAATGGATGTACCAGAATCTTTGTGGGATCAGCCGACTGCTGAAA
CATCTTCATTGTACAAACAGTGTGTGCCAATGGTATCTCAGCATGAGGAA
GTTATCGAGGATTGGTACTTTAATCATCAAGATAAGGATTTAATGGATTT
TTTATGTGTCAAACACGTTCTGAACAATGAATATAACGGTTGTCTAAATG
AAAAATTGTCTCCGGAATCAAAGGAAACAGATTTCGCAACAGAAAATAAC
ACAAATAATTTAGAGACAGCGCACATTTTGTGCATTCTTTAGTTGCAAGC
AAAACTTTACAAAAATCAAGGAAAACATTTCTTTTCGAGAGTTTTCCCTT
TCATATTATTTAGAAACTTTTTTGGTAACATTGAC

protein sequence of SMED30023812-orf-1

>SMED30023812-orf-1 ID=SMED30023812-orf-1|Name=SMED30023812-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=234bp
MKYSGNFIFKFVLILFSFHSYYVFIECSDNEIAEDRHGVKLATKCEVCKI
LAIELISRFKETDKKEVYETGYKLDNKNIIKYEKSELRLTEVIEDPHICE
RMWQYQLHKERKDSTRFAKGIPQTFETLKKLSARGVEIKMDVPESLWDQP
TAETSSLYKQCVPMVSQHEEVIEDWYFNHQDKDLMDFLCVKHVLNNEYNG
CLNEKLSPESKETDFATENNTNNLETAHILCIL*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0005102	signaling receptor binding

Vocabulary: **INTERPRO**
Term	Definition
IPR021852	DUF3456

Vocabulary: **biological process**
Term	Definition
GO:0002376	immune system process
GO:0045087	innate immune response

Vocabulary: **cellular component**
Term	Definition
GO:0005783	endoplasmic reticulum

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR021852	Domain of unknown function DUF3456	PFAM	PF11938	DUF3456	coord: 44..192 e-value: 5.9E-41 score: 140.6
None	No IPR available	PANTHER	PTHR15382:SF6		coord: 33..222
None	No IPR available	PANTHER	PTHR15382	CTG4A-RELATED	coord: 33..222
None	No IPR available	SIGNALP_EUK	SignalP-noTM	SignalP-noTM	coord: 1..27 score: 0.587

Main menu

Protein canopy-like protein 3

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 1

Owlery

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