Histone-lysine N-methyltransferase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30023718 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 1
Homology
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD1 (nuclear receptor binding SET domain protein 1 [Source:HGNC Symbol;Acc:HGNC:14234]) HSP 1 Score: 342.043 bits (876), Expect = 1.462e-97 Identity = 198/572 (34.62%), Postives = 301/572 (52.62%), Query Frame = 2
Query: 491 QSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDC--VDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
++VC CE E +L C C FHL CL L E P K F C +C +GI+ C +C++ +D+ C CG+ YH+ C++ + NK C H CI+C + +L+ C+RCP+++H ND C+AAG+ L+ + +ICP HF + N H+ + +WCF C + G L C+ CPA++H EC++ E + C +C+ ++P Y E+++VKV +YRWWP EI HPR P NI K+ G +PVLF GSN+Y W + R + SS K G +D + L+ A L LR + ++ PY ++K +N+ + ++ A++ P C+C D P +C N + EC T CP +C+NQ F+ + + +F+T RG+GL+T I K +F+ EY+GELI + E R+ A++ + +FYM+ L D +IDAGPKGN +R+MNH C PNC + W VNG + G+FAL +I + ELTF+Y + + C C + NC+GFLG
Sbjct: 1274 ENVCQNCEKLGE---LLLCEAQCCGAFHLECL-GLTE-MPRGK--FICNECRTGIHTCFVCKQSG--EDVKRCLLPLCGKFYHEECVQK---YPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRN-HEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKG---VDGTYKKALQEAA----ARFEELKAQKELRQLQEDRKNDKKPPPYKHIK-VNRPIGRVQIFTADLSEIPR----------CNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLE-CLGNGKTVCKCGAPNCSGFLG 1813 HSP 2 Score: 94.7449 bits (234), Expect = 6.657e-19 Identity = 43/91 (47.25%), Postives = 53/91 (58.24%), Query Frame = 2
Query: 2456 HENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKSICLLH 2728
E+ C+ C D G LV C K CPK YH CL L + P+G W CPWH CDICG+ + FC CP+SFC H +E + I + R S C H
Sbjct: 1848 REDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQH-REGMLFISKLDGRLS-CTEH 1936
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD1 (nuclear receptor binding SET domain protein 1 [Source:HGNC Symbol;Acc:HGNC:14234]) HSP 1 Score: 342.043 bits (876), Expect = 1.462e-97 Identity = 198/572 (34.62%), Postives = 301/572 (52.62%), Query Frame = 2
Query: 491 QSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDC--VDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
++VC CE E +L C C FHL CL L E P K F C +C +GI+ C +C++ +D+ C CG+ YH+ C++ + NK C H CI+C + +L+ C+RCP+++H ND C+AAG+ L+ + +ICP HF + N H+ + +WCF C + G L C+ CPA++H EC++ E + C +C+ ++P Y E+++VKV +YRWWP EI HPR P NI K+ G +PVLF GSN+Y W + R + SS K G +D + L+ A L LR + ++ PY ++K +N+ + ++ A++ P C+C D P +C N + EC T CP +C+NQ F+ + + +F+T RG+GL+T I K +F+ EY+GELI + E R+ A++ + +FYM+ L D +IDAGPKGN +R+MNH C PNC + W VNG + G+FAL +I + ELTF+Y + + C C + NC+GFLG
Sbjct: 1274 ENVCQNCEKLGE---LLLCEAQCCGAFHLECL-GLTE-MPRGK--FICNECRTGIHTCFVCKQSG--EDVKRCLLPLCGKFYHEECVQK---YPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRN-HEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKG---VDGTYKKALQEAA----ARFEELKAQKELRQLQEDRKNDKKPPPYKHIK-VNRPIGRVQIFTADLSEIPR----------CNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLE-CLGNGKTVCKCGAPNCSGFLG 1813 HSP 2 Score: 94.7449 bits (234), Expect = 6.657e-19 Identity = 43/91 (47.25%), Postives = 53/91 (58.24%), Query Frame = 2
Query: 2456 HENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKSICLLH 2728
E+ C+ C D G LV C K CPK YH CL L + P+G W CPWH CDICG+ + FC CP+SFC H +E + I + R S C H
Sbjct: 1848 REDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQH-REGMLFISKLDGRLS-CTEH 1936
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD1 (nuclear receptor binding SET domain protein 1 [Source:HGNC Symbol;Acc:HGNC:14234]) HSP 1 Score: 341.658 bits (875), Expect = 1.919e-97 Identity = 198/572 (34.62%), Postives = 301/572 (52.62%), Query Frame = 2
Query: 491 QSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDC--VDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
++VC CE E +L C C FHL CL L E P K F C +C +GI+ C +C++ +D+ C CG+ YH+ C++ + NK C H CI+C + +L+ C+RCP+++H ND C+AAG+ L+ + +ICP HF + N H+ + +WCF C + G L C+ CPA++H EC++ E + C +C+ ++P Y E+++VKV +YRWWP EI HPR P NI K+ G +PVLF GSN+Y W + R + SS K G +D + L+ A L LR + ++ PY ++K +N+ + ++ A++ P C+C D P +C N + EC T CP +C+NQ F+ + + +F+T RG+GL+T I K +F+ EY+GELI + E R+ A++ + +FYM+ L D +IDAGPKGN +R+MNH C PNC + W VNG + G+FAL +I + ELTF+Y + + C C + NC+GFLG
Sbjct: 1543 ENVCQNCEKLGE---LLLCEAQCCGAFHLECL-GLTE-MPRGK--FICNECRTGIHTCFVCKQSG--EDVKRCLLPLCGKFYHEECVQK---YPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRN-HEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKG---VDGTYKKALQEAA----ARFEELKAQKELRQLQEDRKNDKKPPPYKHIK-VNRPIGRVQIFTADLSEIPR----------CNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLE-CLGNGKTVCKCGAPNCSGFLG 2082 HSP 2 Score: 95.1301 bits (235), Expect = 6.399e-19 Identity = 43/91 (47.25%), Postives = 53/91 (58.24%), Query Frame = 2
Query: 2456 HENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKSICLLH 2728
E+ C+ C D G LV C K CPK YH CL L + P+G W CPWH CDICG+ + FC CP+SFC H +E + I + R S C H
Sbjct: 2117 REDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQH-REGMLFISKLDGRLS-CTEH 2205
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD2 (nuclear receptor binding SET domain protein 2 [Source:HGNC Symbol;Acc:HGNC:12766]) HSP 1 Score: 325.865 bits (834), Expect = 4.685e-93 Identity = 189/590 (32.03%), Postives = 307/590 (52.03%), Query Frame = 2
Query: 449 EIQRLVASPAQYSFQSVCA----VCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDC--VDNCP---KQDCKNYLNKIECQITQCPK---CKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
E Q V+ ++ S + V A VC++ + ++L C G C FHL CL + +P + F C +C SGI+ C +C+ + D+ C + CG+ YH++C++ + + +++ CP H C+SC + + + K++ C+RCP+++H D C+AAG ++ + +IC HF + K + H + +WCF C K G L C CPA++H +C++ + + C +CR ++ + ++++VK+ YRWWP E+ HP+N P NI K+ G +PV F GS +Y W + R + S ++ G + R F + L+ A + I L R + + + PY ++K +N+ K ++ A+I P C+C D P +C N + EC CP C+NQ FT + + KT +G+GL I K +F+ EY+GELI + E R+ +A + + FYM+ + D +IDAGPKGN SR+MNHSC PNC W VNG + G+FA+ +I + ELTF+Y + + E C C ++NC+GFLG
Sbjct: 646 ETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSR--RPEGR--FTCSECASGIHSCFVCK--ESKTDVKRCVVTQCGKFYHEACVKK---YPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRH-HAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQ---GVRGIGRVFKNALQEA---EARFREIKLQ----REARETQESERKPPPYKHIK-VNKPYGKVQIYTADISEIPK----------CNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLD-CLGNEKTVCRCGASNCSGFLG 1203 HSP 2 Score: 107.457 bits (267), Expect = 8.106e-23 Identity = 46/79 (58.23%), Postives = 52/79 (65.82%), Query Frame = 2
Query: 2441 ESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQET 2677
E K E+ C+RC DGG LVLCD+ C K YHLSCLGL + P G W CPWH CD+CG+PS FC CP SFC H T
Sbjct: 1233 EGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGT 1311
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD2 (nuclear receptor binding SET domain protein 2 [Source:HGNC Symbol;Acc:HGNC:12766]) HSP 1 Score: 325.865 bits (834), Expect = 4.685e-93 Identity = 189/590 (32.03%), Postives = 307/590 (52.03%), Query Frame = 2
Query: 449 EIQRLVASPAQYSFQSVCA----VCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDC--VDNCP---KQDCKNYLNKIECQITQCPK---CKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
E Q V+ ++ S + V A VC++ + ++L C G C FHL CL + +P + F C +C SGI+ C +C+ + D+ C + CG+ YH++C++ + + +++ CP H C+SC + + + K++ C+RCP+++H D C+AAG ++ + +IC HF + K + H + +WCF C K G L C CPA++H +C++ + + C +CR ++ + ++++VK+ YRWWP E+ HP+N P NI K+ G +PV F GS +Y W + R + S ++ G + R F + L+ A + I L R + + + PY ++K +N+ K ++ A+I P C+C D P +C N + EC CP C+NQ FT + + KT +G+GL I K +F+ EY+GELI + E R+ +A + + FYM+ + D +IDAGPKGN SR+MNHSC PNC W VNG + G+FA+ +I + ELTF+Y + + E C C ++NC+GFLG
Sbjct: 646 ETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSR--RPEGR--FTCSECASGIHSCFVCK--ESKTDVKRCVVTQCGKFYHEACVKK---YPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRH-HAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQ---GVRGIGRVFKNALQEA---EARFREIKLQ----REARETQESERKPPPYKHIK-VNKPYGKVQIYTADISEIPK----------CNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLD-CLGNEKTVCRCGASNCSGFLG 1203 HSP 2 Score: 107.457 bits (267), Expect = 8.106e-23 Identity = 46/79 (58.23%), Postives = 52/79 (65.82%), Query Frame = 2
Query: 2441 ESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQET 2677
E K E+ C+RC DGG LVLCD+ C K YHLSCLGL + P G W CPWH CD+CG+PS FC CP SFC H T
Sbjct: 1233 EGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGT 1311
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Match: set-12 (Histone-lysine N-methyltransferase [Source:UniProtKB/TrEMBL;Acc:Q21404]) HSP 1 Score: 115.161 bits (287), Expect = 4.239e-27 Identity = 67/184 (36.41%), Postives = 92/184 (50.00%), Query Frame = 2
Query: 1640 CDCVDNCPKQDCKNYLNKIECQITQCPKCKNQQFTNVDHKNIAVFKTSNR-GFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKK--GVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
C C +C ++C N+ N EC C C+NQ+F + F T N G GL+ T I I+EY GE ITK E R+ KK K Y + + +D KGN +R++NHSC+PN ++ W V P K G+FA K I +E+TFDY G + D C C C G++G
Sbjct: 57 CKCGTDCTTEECSNFANHRECP-RGCSNCENQRFRKRQFCGVETFLTDNGIGHGLRATEEIATGKLILEYRGEAITKAEHNKRVKRYKKDGIKHSYSFEVGRNYYVDPTRKGNSARFINHSCNPNALVKVWTVPDRPMKSLGIFASKVIKPGEEITFDY---GTSFRNDQPCQCGEAACRGWIG 236
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Match: met-1 (Histone-lysine N-methyltransferase [Source:UniProtKB/TrEMBL;Acc:A4LBC2]) HSP 1 Score: 104.375 bits (259), Expect = 2.467e-22 Identity = 72/204 (35.29%), Postives = 103/204 (50.49%), Query Frame = 2
Query: 1622 KVQPSICDC---VDNCPKQDCKNYLNKIECQITQCP-----KCKNQQFTNVDHKNIAVFKT-SNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHL---TGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYP----KKGVFALKEIGSDQELTFDYRISGVIMKEDA-FCLCSSNNCTGFLG 2182
K + C+C NC C N +T+CP KCKNQ+F + + F T + +G GL+ I K FIIEY+GE++ +++ E R K+ A + H TG IDA GN SR++NHSCDPN E W V P + G F+ + I + +E+TFDY+ V DA C C S +C+G++G
Sbjct: 635 KTESLTCECHRTGGNCSDNTCVN-----RAMLTECPSSCQVKCKNQRFAKKKYAAVEAFHTGTAKGCGLRAVKDIKKGRFIIEYIGEVVERDDYEKRKT---KYAADKKHKHHYLCDTGVYTIDATVYGNPSRFVNHSCDPNAICEKWSVPRTPGDVNRVGFFSKRFIKAGEEITFDYQF--VNYGRDAQQCFCGSASCSGWIG 828
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Match: met-1 (Histone-lysine N-methyltransferase [Source:UniProtKB/TrEMBL;Acc:A4LBC2]) HSP 1 Score: 104.375 bits (259), Expect = 2.865e-22 Identity = 72/204 (35.29%), Postives = 102/204 (50.00%), Query Frame = 2
Query: 1622 KVQPSICDC---VDNCPKQDCKNYLNKIECQITQCP-----KCKNQQFTNVDHKNIAVFKTSN-RGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHL---TGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYP----KKGVFALKEIGSDQELTFDYRISGVIMKEDA-FCLCSSNNCTGFLG 2182
K + C+C NC C N +T+CP KCKNQ+F + + F T +G GL+ I K FIIEY+GE++ +++ E R K+ A + H TG IDA GN SR++NHSCDPN E W V P + G F+ + I + +E+TFDY+ V DA C C S +C+G++G
Sbjct: 621 KTESLTCECHRTGGNCSDNTCVN-----RAMLTECPSSCQVKCKNQRFAKKKYAAVEAFHTGTAKGCGLRAVKDIKKGRFIIEYIGEVVERDDYEKRKT---KYAADKKHKHHYLCDTGVYTIDATVYGNPSRFVNHSCDPNAICEKWSVPRTPGDVNRVGFFSKRFIKAGEEITFDYQF--VNYGRDAQQCFCGSASCSGWIG 814
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Match: set-23 (Probable histone-lysine N-methyltransferase set-23 [Source:UniProtKB/Swiss-Prot;Acc:Q95Y12]) HSP 1 Score: 85.8853 bits (211), Expect = 2.596e-18 Identity = 53/169 (31.36%), Postives = 84/169 (49.70%), Query Frame = 2
Query: 1724 CKNQQFTNVDHKNIAVFKTSN--RGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHL----TGDLV---IDAGPKGNLSRYMNHSCDPNC-YLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLGPIKSLP 2200
C+N+ K + +F T +GFG++ I +F+ EY GE I + E E R ++F D Y + L G V +D +GN+ R++NHSC+PNC + + P G+FA ++I +EL +DY S + + CLC S C +L P+ + P
Sbjct: 78 CRNRVVQCGPQKKLEIFSTCEMAKGFGVRAGEQIAAGEFVCEYAGECIGEQEVERR---CREFRGDDNYTLTLKEFFGGKPVKTFVDPRLRGNIGRFLNHSCEPNCEIILARLGRMIPAAGIFAKRDIVRGEELCYDYGHSAIEGENRKLCLCKSEKCRKYL-PMSATP 242
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Match: mes-4 (Histone-lysine N-methyltransferase mes-4 [Source:UniProtKB/Swiss-Prot;Acc:Q9NH52]) HSP 1 Score: 90.5077 bits (223), Expect = 4.167e-18 Identity = 63/202 (31.19%), Postives = 102/202 (50.50%), Query Frame = 2
Query: 1640 CDCVDNCPKQDCKNYLNKIECQITQCPK---CKNQQFT-NVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLN---AKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKG-----------VFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLGPIK 2191
C+ D C K C+ + EC + C K C N+Q + + + I + T +G+G+ I K+++I EY+GE+I K E + R+ + ++ F A + YM+ L L +DA GN+SRY+NHSCDPN +++ + KK + A++ I E+TF Y ++ D C C + NC G +G K
Sbjct: 495 CEGADRCTKLSCQYLADDYECPPS-CSKKGVCHNRQVSMGIVSEKIKLAATLCKGYGVFAKGQIEKDEYICEYVGEIIDKAEKKRRLDSVSISRDFQA-NHYMMELHKGLTVDAARYGNISRYINHSCDPNA--ASFVTKVFVKKTKEGSLYDTRSYIRAIRTIDDGDEITFSYNMNNEENLPD--CECGAENCMGTMGKAK 690
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Match: NSD (gene:FBgn0039559 transcript:FBtr0085267) HSP 1 Score: 270.011 bits (689), Expect = 1.931e-74 Identity = 176/632 (27.85%), Postives = 287/632 (45.41%), Query Frame = 2
Query: 485 SFQSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSK----------------------------------PNFQCLDCFSG-IYHCILCQKVDKI------------------DDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDAT--FAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIEC--VSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQP-SICDC--VDN---CPKQDCKNYLNKIECQITQCPK---CKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
S + +C C Y + +++C+ C + H CL+ P K + C +C G C++C +V+ D LL C CG+ +H SC + H + CP H C +CV +D + F Q KL +C+RCP ++H C+ AG L+ +++ICP+H + K +AH + WC+ C K G + C CP + H C + + ES Y+C C + R P YGE+++ K + +RWWP I+ P P NILK + + V F G++++ W+++ R + K +++ R++++G+ A + + ++ + + +L+P VK IK N VPP + ++ S C+C VD P+ C N + EC C C+N+ F + V + RGFGL PI DF+IEY+GE+I E + RM ++ +++Y + + D +IDAGPKGNL+R+MNHSC+PNC + W VN + G+FA+K+I + ELTF+Y ++ C C + C+G +G
Sbjct: 775 SREPICKYC--YQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSAR---CPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRH---NIAKADAH--VNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNES-YICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTK---SQLFRNYTTGVEEASRF------LPIIKARRQEQDMERQSGNKLHPPPYVK-----------IKTNKAVPPLRFSQNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIG 1375
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Match: NSD (gene:FBgn0039559 transcript:FBtr0335014) HSP 1 Score: 270.011 bits (689), Expect = 2.154e-74 Identity = 176/632 (27.85%), Postives = 287/632 (45.41%), Query Frame = 2
Query: 485 SFQSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSK----------------------------------PNFQCLDCFSG-IYHCILCQKVDKI------------------DDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDAT--FAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIEC--VSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQP-SICDC--VDN---CPKQDCKNYLNKIECQITQCPK---CKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
S + +C C Y + +++C+ C + H CL+ P K + C +C G C++C +V+ D LL C CG+ +H SC + H + CP H C +CV +D + F Q KL +C+RCP ++H C+ AG L+ +++ICP+H + K +AH + WC+ C K G + C CP + H C + + ES Y+C C + R P YGE+++ K + +RWWP I+ P P NILK + + V F G++++ W+++ R + K +++ R++++G+ A + + ++ + + +L+P VK IK N VPP + ++ S C+C VD P+ C N + EC C C+N+ F + V + RGFGL PI DF+IEY+GE+I E + RM ++ +++Y + + D +IDAGPKGNL+R+MNHSC+PNC + W VN + G+FA+K+I + ELTF+Y ++ C C + C+G +G
Sbjct: 771 SREPICKYC--YQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSAR---CPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRH---NIAKADAH--VNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNES-YICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTK---SQLFRNYTTGVEEASRF------LPIIKARRQEQDMERQSGNKLHPPPYVK-----------IKTNKAVPPLRFSQNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIG 1371
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Match: ash1 (gene:FBgn0005386 transcript:FBtr0306009) HSP 1 Score: 129.798 bits (325), Expect = 5.969e-30 Identity = 72/208 (34.62%), Postives = 113/208 (54.33%), Query Frame = 2
Query: 1646 CVDNCPKQDCKNYLNKIECQITQCP---KCKNQQFT-NVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG-------PIKSLPNSPVKSQLTSRN 2236
C+DNC N + EC + CP KC+NQ+ + + F T+++G+G++T +PI K +I+EY+GE++T+ E + RM + N Y +HL G LVID G+ R++NHSC+PNC ++ W VNG + +FA + I +ELT+DY S E C C++ C G +G P+ ++ P L+ RN
Sbjct: 1354 CLDNC-----LNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIY-LNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGLSGRN 1555
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Match: ash1 (gene:FBgn0005386 transcript:FBtr0306010) HSP 1 Score: 129.798 bits (325), Expect = 5.969e-30 Identity = 72/208 (34.62%), Postives = 113/208 (54.33%), Query Frame = 2
Query: 1646 CVDNCPKQDCKNYLNKIECQITQCP---KCKNQQFT-NVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG-------PIKSLPNSPVKSQLTSRN 2236
C+DNC N + EC + CP KC+NQ+ + + F T+++G+G++T +PI K +I+EY+GE++T+ E + RM + N Y +HL G LVID G+ R++NHSC+PNC ++ W VNG + +FA + I +ELT+DY S E C C++ C G +G P+ ++ P L+ RN
Sbjct: 1354 CLDNC-----LNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIY-LNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGLSGRN 1555
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Match: Set2 (gene:FBgn0030486 transcript:FBtr0073779) HSP 1 Score: 125.946 bits (315), Expect = 1.007e-28 Identity = 83/260 (31.92%), Postives = 129/260 (49.62%), Query Frame = 2
Query: 1517 EELYPYVNVKEINQKTVK------FKLIKANIIVPPAKLPPKVQPSICDCVDNCPKQ---------DCKNYLNKIECQ--ITQCPKCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDA-FCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSS 2242
E+L N++ IN++ ++ F+L+K N ++ + CDC ++ C N + IEC + +C N++F VF+T +G G+ + I +FI+EY+GE+I E E R K + +Y + L G+ VIDA KGN+SRY+NHSCDPN + W VNG + G F++K I +E+TFDY+ + DA C C + NC G++G P+S QL + S
Sbjct: 1314 EQLAELANIEAINEQFLRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCFLTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQY--LRYGRDAQRCYCEAANCRGWIG---GEPDSDEGEQLDEESDS 1568
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581]) HSP 1 Score: 340.887 bits (873), Expect = 3.778e-98 Identity = 212/663 (31.98%), Postives = 327/663 (49.32%), Query Frame = 2
Query: 296 KIDENDHRKSIKSRKPQRSPSPNLKKYRKDSLHNENSVIKIEKESVPIFQMEIQRLVASPAQYS----------------FQSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILL-MHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVDNCPKQDCKNY-----------LNKI---ECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
K D +++RK K + + P P K+ RK + K+ P E +R SP+ + +SVC VCE E+ ++ C G C +HLHC+ + S C C +G++ C C+K + ++ C CGR YH++C+ +S + + +N+ CP H C+SC + K++ CLRCP+++H DLC+AAG+ +S S ++C HF K + H + +WCF C K G L C CPA++H +C++ + + C +CR+ ++P+Y +V++VK+ YRWWP EI HP+N P NI L G +PV F GS +Y W + R + S ++++G I +V+ N LL + I E E N+K FK IK N K +VQ D + PK +CK LN++ EC CP +C+NQ FT + + +T+ +G+GL + I K +F+ EY+GELI + E R+ +A++ + FYM+ + D +IDAGPKGN SR+MNHSC PNC + W VNG + G+FA+ +I + ELTF+Y + + E C C + NC+GFLG
Sbjct: 680 KTDRDENRKRSK-KASKEEPPPKAKRGRKRKEESGRQSFPASKKCRPSSYAEPER-PDSPSDSTDESHPSKKAERTPGAKKESVCLVCEQTGED--IVTCAGQCYGTYHLHCIGVER-----SAEKILCTACSTGVHVCFTCKKSE--GEVRRCCALHCGRFYHEACVRLS---ALTVFENRGFRCPLHTCLSCHYSGRAACKATKGKMMRCLRCPVAYHVGDLCVAAGSEMISSSAIVCTNHFRAK-KGYSHHSHVNVSWCFICSKGGRLLCCESCPAAFHPDCLNIAMPDGSWFCNDCRSGKKPKYRDVIWVKLGNYRWWPAEIRHPKNIPTNIQHLRHEIGEFPVFFFGSKDYFWTHQGRVFPYMEGDRGSKYQQTG------------------IGKVFKNALLDAETRFKEIEMEREAKE-------AHENNKKPPPFKYIKVN------KPCGRVQVYTAD-ISEIPKCNCKPSTERPCSFESECLNRMLLYECHPQVCPAGERCQNQDFTKRLYPETKIIRTAGKGWGLISLRDIKKGEFVNEYVGELIDEEECRSRIRHAQENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCDIPAGTELTFNYNLD-CLGNEKTVCRCGAPNCSGFLG 1294 HSP 2 Score: 99.7525 bits (247), Expect = 1.188e-20 Identity = 41/71 (57.75%), Postives = 48/71 (67.61%), Query Frame = 2
Query: 2459 ENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQ 2671
E+ C+RC DGG LVLCDK C K YHLSCL + P G W CPWH CD+CG+ S FC CP SFC +H +
Sbjct: 1327 EDECFRCGDGGQLVLCDKKGCTKAYHLSCLDRTKRPFGRWDCPWHHCDVCGKNSAAFCQLCPNSFCKAHQE 1397
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:ZFIN;Acc:ZDB-GENE-050324-2]) HSP 1 Score: 334.724 bits (857), Expect = 7.630e-96 Identity = 203/583 (34.82%), Postives = 301/583 (51.63%), Query Frame = 2
Query: 494 SVCAVCEIYTENNAVLQCTGICKRYFHLHCL--KNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAH--KPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVD----NCPKQD---------CKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
+VC VCE + ++++ C G C R FH C+ + KE++ C +C +G + C C+ + D+ C + CGR YH++C+ + G D K L CP H C +C D + +++ C+RCP+++H D C+AAG+ ++ +IC H ++ N H P + WCF C + G L C CPAS+H EC+ E ++C C++ ++P Y ++++VK+ YRWWP EI +PR P NI L G +PV F GS++Y W+ + R F + F E G +++ F L A K Q + A T E L N +++ +KLIK+N K KVQ + D + NC D C N + + EC CP +C NQ F+ + + V KT+ RG+GLKT + K DF++EY+GELI E + R+ A + + +FYM+ LT D VIDAGPKGNLSR+MNHSC PNC + W VNG + G+F L +I +D ELTF+Y + + C C S NC+GFLG
Sbjct: 848 TVCHVCETF--GDSLVSCEGDCNRLFHPECMGSNSGKESETV------CQECKTGSHPCFSCKVTE--GDMKRCSVNGCGRYYHETCVR--KYTG-SASDTKGLRCPQHSCATCCL-DRDLQKAGKGRMMRCIRCPVAYHTGDGCVAAGSVLITPHIIICSNHSSSRK---NGHFSSPVNVGWCFICARGGRLLCCEACPASFHPECLKIEMPEGTWLCGECKSGKKPHYKQIVWVKLGNYRWWPAEICNPRLVPSNIQSLKHDIGDFPVFFFGSHDYYWINQGRV--FPYVESDKNFAE--GQVGINKTFKKALEEAAKRFQ-------------ELKAQRETKEALEQERN----SRRPPPYKLIKSN------KPFGKVQLHVADLSEIPRCNCKPTDERPCSQDSQCLNRMLQYECHPQVCPAGDRCHNQCFSKRLYPDTEVIKTTGRGWGLKTKQDLKKGDFVMEYVGELIDSEECKQRIRTANENHVTNFYMLTLTKDRVIDAGPKGNLSRFMNHSCSPNCETQKWTVNGDVRIGLFTLCDISADTELTFNYNLD-CLGNGRTSCHCGSENCSGFLG 1385 HSP 2 Score: 100.523 bits (249), Expect = 6.270e-21 Identity = 42/76 (55.26%), Postives = 50/76 (65.79%), Query Frame = 2
Query: 2438 VESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSH 2665
ESK HE +CY C +GG LV+CDK +CPK YHL CL L + P G W CPWH C +C + + FC CPASFC H
Sbjct: 1414 TESKQTHELYCYCCGEGGELVMCDKKDCPKAYHLLCLNLSKPPYGRWECPWHQCSVCQRTATSFCHFCPASFCREH 1489
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:ZFIN;Acc:ZDB-GENE-050324-2]) HSP 1 Score: 334.339 bits (856), Expect = 7.933e-96 Identity = 203/583 (34.82%), Postives = 301/583 (51.63%), Query Frame = 2
Query: 494 SVCAVCEIYTENNAVLQCTGICKRYFHLHCL--KNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAH--KPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVD----NCPKQD---------CKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
+VC VCE + ++++ C G C R FH C+ + KE++ C +C +G + C C+ + D+ C + CGR YH++C+ + G D K L CP H C +C D + +++ C+RCP+++H D C+AAG+ ++ +IC H ++ N H P + WCF C + G L C CPAS+H EC+ E ++C C++ ++P Y ++++VK+ YRWWP EI +PR P NI L G +PV F GS++Y W+ + R F + F E G +++ F L A K Q + A T E L N +++ +KLIK+N K KVQ + D + NC D C N + + EC CP +C NQ F+ + + V KT+ RG+GLKT + K DF++EY+GELI E + R+ A + + +FYM+ LT D VIDAGPKGNLSR+MNHSC PNC + W VNG + G+F L +I +D ELTF+Y + + C C S NC+GFLG
Sbjct: 812 TVCHVCETF--GDSLVSCEGDCNRLFHPECMGSNSGKESETV------CQECKTGSHPCFSCKVTE--GDMKRCSVNGCGRYYHETCVR--KYTG-SASDTKGLRCPQHSCATCCL-DRDLQKAGKGRMMRCIRCPVAYHTGDGCVAAGSVLITPHIIICSNHSSSRK---NGHFSSPVNVGWCFICARGGRLLCCEACPASFHPECLKIEMPEGTWLCGECKSGKKPHYKQIVWVKLGNYRWWPAEICNPRLVPSNIQSLKHDIGDFPVFFFGSHDYYWINQGRV--FPYVESDKNFAE--GQVGINKTFKKALEEAAKRFQ-------------ELKAQRETKEALEQERN----SRRPPPYKLIKSN------KPFGKVQLHVADLSEIPRCNCKPTDERPCSQDSQCLNRMLQYECHPQVCPAGDRCHNQCFSKRLYPDTEVIKTTGRGWGLKTKQDLKKGDFVMEYVGELIDSEECKQRIRTANENHVTNFYMLTLTKDRVIDAGPKGNLSRFMNHSCSPNCETQKWTVNGDVRIGLFTLCDISADTELTFNYNLD-CLGNGRTSCHCGSENCSGFLG 1349 HSP 2 Score: 100.523 bits (249), Expect = 6.265e-21 Identity = 42/76 (55.26%), Postives = 50/76 (65.79%), Query Frame = 2
Query: 2438 VESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSH 2665
ESK HE +CY C +GG LV+CDK +CPK YHL CL L + P G W CPWH C +C + + FC CPASFC H
Sbjct: 1378 TESKQTHELYCYCCGEGGELVMCDKKDCPKAYHLLCLNLSKPPYGRWECPWHQCSVCQRTATSFCHFCPASFCREH 1453
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd1a (nuclear receptor binding SET domain protein 1a [Source:ZFIN;Acc:ZDB-GENE-080519-3]) HSP 1 Score: 333.569 bits (854), Expect = 4.961e-95 Identity = 197/575 (34.26%), Postives = 299/575 (52.00%), Query Frame = 2
Query: 491 QSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPC---KKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDC--VDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
++VC VCE E +L C G C FHL C+ L E T K F C +C G++ C +C+K DK ++ C CG+ YH C+ + + N+ C H C+SC T NP +L C+RCP+++H ND CMAAG+ L+ + +CP HF + N H+ + +WCF C + G L C CPA++H EC++ + + C +CR ++P Y ++L+VKV +YRWWP E+ P++ P NI ++ G +PV F GS +Y W + R + ++ K G D + L A LL +R + ++ PY ++K +N++ K +I A++ P C+C D P +C N + EC CP +C+NQ FT + + +F+T +RG+GL++ I K F+ EY+GE+I + E R+ NA+ + +FYM+ L D +IDAGPKGN SR+MNHSC PNC + W VNG + G+FAL++I ELTF+Y + + C C + NC+GFLG
Sbjct: 1226 ENVCQVCEKTGE---LLLCEGQCCGAFHLQCI-GLTE---TPKGRFICQECKMGVHTCFVCKKPDK--EVRRCMIPVCGKFYHMDCILKYSPT---VAQNRGFRCSIHVCLSCY---ITNPNNPGISKGRLTRCVRCPVAYHANDYCMAAGSVPLANNSFLCPNHFTPRKGCKN-HEHINVSWCFVCSEGGSLLCCESCPAAFHRECLNIEMPQGSWFCNDCRAGKKPHYKDILWVKVGRYRWWPAEVTQPKSVPENISRMKHEVGEFPVHFFGSKDYVWTYQARCFPYMEGDANNKEKMGKGA---DAVYKKALNEAAD----RFRELLKEKEMRQLQEDRKNDKKPPPYKHIK-VNKQIGKVLIITADLSEIPR----------CNCKATDENPCGIDSECINRMLLYECHSQVCPAGERCQNQSFTKRQYTEVEIFRTLSRGWGLRSISDIKKGAFVNEYVGEVIDEEECRSRIKNAQDNDICNFYMLTLDKDRIIDAGPKGNESRFMNHSCQPNCETQKWTVNGDTRVGLFALEDIPKGVELTFNYNLE-CLGNGKTVCKCGAPNCSGFLG 1765 HSP 2 Score: 88.5817 bits (218), Expect = 3.342e-17 Identity = 36/83 (43.37%), Postives = 48/83 (57.83%), Query Frame = 2
Query: 2423 KDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQ 2671
K K E E+ C+ C DGG +V C K CPK YH CL L + P+G W CPWH C+ CG+ + +C CP S+C+ H +
Sbjct: 1788 KRKSQSEVTKEREDECFYCGDGGQIVSCKKPGCPKVYHADCLNLSKRPAGRWECPWHQCNECGREAASYCEMCPNSYCEQHRE 1870
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd1a (nuclear receptor binding SET domain protein 1a [Source:ZFIN;Acc:ZDB-GENE-080519-3]) HSP 1 Score: 333.569 bits (854), Expect = 5.233e-95 Identity = 199/576 (34.55%), Postives = 300/576 (52.08%), Query Frame = 2
Query: 491 QSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSC-LEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPC---KKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDC--VDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
++VC VCE E +L C G C FHL C+ L E T K F C +C G++ C +C+K DK ++ C CG+ YH C L+ S + N+ C H C+SC T NP +L C+RCP+++H ND CMAAG+ L+ + +CP HF + N H+ + +WCF C + G L C CPA++H EC++ + + C +CR ++P Y ++L+VKV +YRWWP E+ P++ P NI ++ G +PV F GS +Y W + R + ++ K G D + L A LL +R + ++ PY ++K +N++ K +I A++ P C+C D P +C N + EC CP +C+NQ FT + + +F+T +RG+GL++ I K F+ EY+GE+I + E R+ NA+ + +FYM+ L D +IDAGPKGN SR+MNHSC PNC + W VNG + G+FAL++I ELTF+Y + + C C + NC+GFLG
Sbjct: 1242 ENVCQVCEKTGE---LLLCEGQCCGAFHLQCI-GLTE---TPKGRFICQECKMGVHTCFVCKKPDK--EVRRCMIPVCGKFYHMDCILKYSPTVA----QNRGFRCSIHVCLSCY---ITNPNNPGISKGRLTRCVRCPVAYHANDYCMAAGSVPLANNSFLCPNHFTPRKGCKN-HEHINVSWCFVCSEGGSLLCCESCPAAFHRECLNIEMPQGSWFCNDCRAGKKPHYKDILWVKVGRYRWWPAEVTQPKSVPENISRMKHEVGEFPVHFFGSKDYVWTYQARCFPYMEGDANNKEKMGKGA---DAVYKKALNEAAD----RFRELLKEKEMRQLQEDRKNDKKPPPYKHIK-VNKQIGKVLIITADLSEIPR----------CNCKATDENPCGIDSECINRMLLYECHSQVCPAGERCQNQSFTKRQYTEVEIFRTLSRGWGLRSISDIKKGAFVNEYVGEVIDEEECRSRIKNAQDNDICNFYMLTLDKDRIIDAGPKGNESRFMNHSCQPNCETQKWTVNGDTRVGLFALEDIPKGVELTFNYNLE-CLGNGKTVCKCGAPNCSGFLG 1781 HSP 2 Score: 88.5817 bits (218), Expect = 3.493e-17 Identity = 36/83 (43.37%), Postives = 48/83 (57.83%), Query Frame = 2
Query: 2423 KDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQ 2671
K K E E+ C+ C DGG +V C K CPK YH CL L + P+G W CPWH C+ CG+ + +C CP S+C+ H +
Sbjct: 1804 KRKSQSEVTKEREDECFYCGDGGQIVSCKKPGCPKVYHADCLNLSKRPAGRWECPWHQCNECGREAASYCEMCPNSYCEQHRE 1886
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD3 (Triosephosphate isomerase [Source:UniProtKB/Swiss-Prot;Acc:B0BM40]) HSP 1 Score: 387.111 bits (993), Expect = 1.328e-114 Identity = 245/736 (33.29%), Postives = 359/736 (48.78%), Query Frame = 2
Query: 500 CAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCK-KLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHC-NYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSI--CDC--VDNCP---KQDCKNYLNKIECQITQCPK---CKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRIS--GVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSH 2665
C +CE Y E +++ C G C R FHL CL + P K F C++C +G++ C C+ + C CG+ YH++C I D+K CP H C SC + + CK +++ C+RCP+++H D C+AAG+ LS S +IC H + +A + +CF C + G KL C + CPA++H C++ + + C +CR+ ++ Y ++++VK+ YRWWP EI +PR+ P+NI L G +PV F GS++Y WV + R + S + G T +++ F L A + Q + A + E L +++ ++K +K IK+N V ++ I C+C D+ P +C N + EC CP C NQ FT + +F T RG+GL+T I K +F+ EY+GELI + E RM A + +FY++ +T D +IDAGPKGN SR+MNHSC+PNC + W VNG + G+FAL +I ELTF+Y + G +E C C + NC+GFL G+ K + ++ SK +K L +E ++E F C+RC DGG LV+CDK +CPK YHL CL L + P G W CPWH CDICG S FC CPASFC H
Sbjct: 717 CQICESYGE--SLVSCDGECSRLFHLECLG--MDTLPDGK--FICMECKTGLHTCFSCKIPST--SVKRCSAPCCGKFYHETCARQ---YSATIFDSKGFRCPHHCCSSCTADKDPY--RACKGRMLSCVRCPVAYHNGDSCIAAGSLHLSSSLIICSNHSKRSG---HASSSVNVGFCFVCARGGGKLLCCDSCPAAFHPSCLNLEMPQGSWSCNDCRSGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSF----ADGQTSINKTFKKALEEAARRFQ-------------ELKAQRESKEAL----EIEQNSRKPPPYKHIKSNKPVGKVQIQLADLSEIPRCNCRPTDDTPCGLDTECLNRMLLYECHPQICPAGEHCLNQNFTKRLYPEAEIFITERRGWGLRTKRDIRKGEFVNEYVGELIDEEECRQRMKRAHENGTTNFYLLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPKGAELTFNYNLDCLGNGRRE---CHCGAENCSGFL--------------------------GVRPKTACATATEERSKNARLKAKKRKLKTEQKQMHEDF-------------------------------CFRCGDGGELVMCDKRDCPKAYHLLCLNLTQPPYGKWDCPWHQCDICGAASSSFCDFCPASFCREH 1355
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD3 (Triosephosphate isomerase [Source:UniProtKB/Swiss-Prot;Acc:B0BM40]) HSP 1 Score: 382.874 bits (982), Expect = 1.402e-114 Identity = 244/735 (33.20%), Postives = 362/735 (49.25%), Query Frame = 2
Query: 506 VCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCK-KLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSI--CDC--VDNCP---KQDCKNYLNKIECQITQCPK---CKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRIS--GVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQ 2671
+CE Y E +++ C G C R FHL CL + P K F C++C +G++ C C+ + C CG+ YH++C I D+K CP H C SC + + CK +++ C+RCP+++H D C+AAG+ LS S +IC H + +A + +CF C + G L C+ CPA++H C++ + + C +CR+ ++ Y ++++VK+ YRWWP EI +PR+ P+NI L G +PV F GS++Y WV + R + S + G T +++ F L A + Q + A + E L +++ ++K +K IK+N V ++ I C+C D+ P +C N + EC CP C NQ FT + +F T RG+GL+T I K +F+ EY+GELI + E RM A + +FY++ +T D +IDAGPKGN SR+MNHSC+PNC + W VNG + G+FAL +I ELTF+Y + G +E C C + NC+GFLG V+ ++T ++ ++ SK +K L +E ++E F C+RC DGG LV+CDK +CPK YHL CL L + P G W CPWH CDICG S FC CPASFC H +
Sbjct: 494 ICESYGE--SLVSCDGECSRLFHLECLG--MDTLPDGK--FICMECKTGLHTCFSCKIPST--SVKRCSAPCCGKFYHETCARQ---YSATIFDSKGFRCPHHCCSSCTADKDPY--RACKGRMLSCVRCPVAYHNGDSCIAAGSLHLSSSLIICSNHSKRSG---HASSSVNVGFCFVCARGGKLLCCDSCPAAFHPSCLNLEMPQGSWSCNDCRSGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSF----ADGQTSINKTFKKALEEAARRFQ-------------ELKAQRESKEAL----EIEQNSRKPPPYKHIKSNKPVGKVQIQLADLSEIPRCNCRPTDDTPCGLDTECLNRMLLYECHPQICPAGEHCLNQNFTKRLYPEAEIFITERRGWGLRTKRDIRKGEFVNEYVGELIDEEECRQRMKRAHENGTTNFYLLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPKGAELTFNYNLDCLGNGRRE---CHCGAENCSGFLG---------VRPKVTCATAT-----------------EERSKNARLKAKKRKLKTEQKQMHEDF-------------------------------CFRCGDGGELVMCDKRDCPKAYHLLCLNLTQPPYGKWDCPWHQCDICGAASSSFCDFCPASFCREHEK 1131
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD3 (Triosephosphate isomerase [Source:UniProtKB/Swiss-Prot;Acc:B0BM40]) HSP 1 Score: 385.185 bits (988), Expect = 3.264e-114 Identity = 244/737 (33.11%), Postives = 357/737 (48.44%), Query Frame = 2
Query: 500 CAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCK-KLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSI--CDC--VDNCP---KQDCKNYLNKIECQITQCPK---CKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRIS--GVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQ 2671
C +CE Y E +++ C G C R FHL CL + P K F C++C +G H K+ + C CG+ YH++C I D+K CP H C SC + + CK +++ C+RCP+++H D C+AAG+ LS S +IC H + +A + +CF C + G L C+ CPA++H C++ + + C +CR+ ++ Y ++++VK+ YRWWP EI +PR+ P+NI L G +PV F GS++Y WV + R + S + G T +++ F L A + Q + A + E L +++ ++K +K IK+N V ++ I C+C D+ P +C N + EC CP C NQ FT + +F T RG+GL+T I K +F+ EY+GELI + E RM A + +FY++ +T D +IDAGPKGN SR+MNHSC+PNC + W VNG + G+FAL +I ELTF+Y + G +E C C + NC+GFL G+ K + ++ SK +K L +E ++E F C+RC DGG LV+CDK +CPK YHL CL L + P G W CPWH CDICG S FC CPASFC H +
Sbjct: 668 CQICESYGE--SLVSCDGECSRLFHLECLG--MDTLPDGK--FICMECKTGSLHTCFSCKIPSTS-VKRCSAPCCGKFYHETCARQ---YSATIFDSKGFRCPHHCCSSCTADKDPY--RACKGRMLSCVRCPVAYHNGDSCIAAGSLHLSSSLIICSNHSKRSG---HASSSVNVGFCFVCARGGKLLCCDSCPAAFHPSCLNLEMPQGSWSCNDCRSGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSF----ADGQTSINKTFKKALEEAARRFQ-------------ELKAQRESKEAL----EIEQNSRKPPPYKHIKSNKPVGKVQIQLADLSEIPRCNCRPTDDTPCGLDTECLNRMLLYECHPQICPAGEHCLNQNFTKRLYPEAEIFITERRGWGLRTKRDIRKGEFVNEYVGELIDEEECRQRMKRAHENGTTNFYLLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPKGAELTFNYNLDCLGNGRRE---CHCGAENCSGFL--------------------------GVRPKTACATATEERSKNARLKAKKRKLKTEQKQMHEDF-------------------------------CFRCGDGGELVMCDKRDCPKAYHLLCLNLTQPPYGKWDCPWHQCDICGAASSSFCDFCPASFCREHEK 1308
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD3 (Triosephosphate isomerase [Source:UniProtKB/Swiss-Prot;Acc:B0BM40]) HSP 1 Score: 382.104 bits (980), Expect = 5.954e-113 Identity = 244/741 (32.93%), Postives = 358/741 (48.31%), Query Frame = 2
Query: 500 CAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCK-KLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYR------WWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSI--CDC--VDNCP---KQDCKNYLNKIECQITQCPK---CKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRIS--GVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSH 2665
C +CE Y E +++ C G C R FHL CL + P K F C++C +G++ C C+ + C CG+ YH++C I D+K CP H C SC + + CK +++ C+RCP+++H D C+AAG+ LS S +IC H + +A + +CF C + G L C+ CPA++H C++ + + C +CR+ ++ Y ++++VK+ YR WWP EI +PR+ P+NI L G +PV F GS++Y WV + R + S + G T +++ F L A + Q + A + E L +++ ++K +K IK+N V ++ I C+C D+ P +C N + EC CP C NQ FT + +F T RG+GL+T I K +F+ EY+GELI + E RM A + +FY++ +T D +IDAGPKGN SR+MNHSC+PNC + W VNG + G+FAL +I ELTF+Y + G +E C C + NC+GFL G+ K + ++ SK +K L +E ++E F C+RC DGG LV+CDK +CPK YHL CL L + P G W CPWH CDICG S FC CPASFC H
Sbjct: 695 CQICESYGE--SLVSCDGECSRLFHLECLG--MDTLPDGK--FICMECKTGLHTCFSCKIPST--SVKRCSAPCCGKFYHETCARQ---YSATIFDSKGFRCPHHCCSSCTADKDPY--RACKGRMLSCVRCPVAYHNGDSCIAAGSLHLSSSLIICSNHSKRSG---HASSSVNVGFCFVCARGGKLLCCDSCPAAFHPSCLNLEMPQGSWSCNDCRSGKKLHYKQIVWVKLGNYRQVELSVWWPAEICNPRSVPLNIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSF----ADGQTSINKTFKKALEEAARRFQ-------------ELKAQRESKEAL----EIEQNSRKPPPYKHIKSNKPVGKVQIQLADLSEIPRCNCRPTDDTPCGLDTECLNRMLLYECHPQICPAGEHCLNQNFTKRLYPEAEIFITERRGWGLRTKRDIRKGEFVNEYVGELIDEEECRQRMKRAHENGTTNFYLLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPKGAELTFNYNLDCLGNGRRE---CHCGAENCSGFL--------------------------GVRPKTACATATEERSKNARLKAKKRKLKTEQKQMHEDF-------------------------------CFRCGDGGELVMCDKRDCPKAYHLLCLNLTQPPYGKWDCPWHQCDICGAASSSFCDFCPASFCREH 1338
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD3 (Triosephosphate isomerase [Source:UniProtKB/Swiss-Prot;Acc:B0BM40]) HSP 1 Score: 371.703 bits (953), Expect = 6.052e-109 Identity = 246/780 (31.54%), Postives = 360/780 (46.15%), Query Frame = 2
Query: 500 CAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCK-KLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFEN---------------------------------------------KLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSI--CDC--VDNCP---KQDCKNYLNKIECQITQCPK---CKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRIS--GVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSH 2665
C +CE Y E +++ C G C R FHL CL + P K F C++C +G++ C C+ + C CG+ YH++C I D+K CP H C SC + + CK +++ C+RCP+++H D C+AAG+ LS S +IC H + +L+K+ PA+ K K G L C+ CPA++H C++ + + C +CR+ ++ Y ++++VK+ YRWWP EI +PR+ P+NI L G +PV F GS++Y WV + R + S + G T +++ F L A + Q + A + E L +++ ++K +K IK+N V ++ I C+C D+ P +C N + EC CP C NQ FT + +F T RG+GL+T I K +F+ EY+GELI + E RM A + +FY++ +T D +IDAGPKGN SR+MNHSC+PNC + W VNG + G+FAL +I ELTF+Y + G +E C C + NC+GFL G+ K + ++ SK +K L +E ++E F C+RC DGG LV+CDK +CPK YHL CL L + P G W CPWH CDICG S FC CPASFC H
Sbjct: 710 CQICESYGE--SLVSCDGECSRLFHLECLG--MDTLPDGK--FICMECKTGLHTCFSCKIPST--SVKRCSAPCCGKFYHETCARQ---YSATIFDSKGFRCPHHCCSSCTADKDPY--RACKGRMLSCVRCPVAYHNGDSCIAAGSLHLSSSLIICSNHSKRSGHASSSVNVGFCFVCARGLIVQDYSLVSSMSFKSHFLLTDSKRAELMKIPMIPSSSPAYIKKSEKGGKLLCCDSCPAAFHPSCLNLEMPQGSWSCNDCRSGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSF----ADGQTSINKTFKKALEEAARRFQ-------------ELKAQRESKEAL----EIEQNSRKPPPYKHIKSNKPVGKVQIQLADLSEIPRCNCRPTDDTPCGLDTECLNRMLLYECHPQICPAGEHCLNQNFTKRLYPEAEIFITERRGWGLRTKRDIRKGEFVNEYVGELIDEEECRQRMKRAHENGTTNFYLLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPKGAELTFNYNLDCLGNGRRE---CHCGAENCSGFL--------------------------GVRPKTACATATEERSKNARLKAKKRKLKTEQKQMHEDF-------------------------------CFRCGDGGELVMCDKRDCPKAYHLLCLNLTQPPYGKWDCPWHQCDICGAASSSFCDFCPASFCREH 1395
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd1 (nuclear receptor-binding SET-domain protein 1 [Source:MGI Symbol;Acc:MGI:1276545]) HSP 1 Score: 411.379 bits (1056), Expect = 4.115e-121 Identity = 249/754 (33.02%), Postives = 368/754 (48.81%), Query Frame = 2
Query: 491 QSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDC--VDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKSICLLH 2728
++VC CE E +L C C FHL CL L E P K F C +C +GI+ C +C++ +D+ C CG+ YH+ C++ + NK CP H CI+C + +L+ C+RCP+++H ND C+AAG+ L+ + +ICP HF + N H+ + +WCF C + G L C+ CPA++H EC++ E + C +C+ ++P Y E+++VKV +YRWWP EI HPR P NI K+ G +PVLF GSN+Y W + R + SS K G +D + L+ A L LR + ++ PY ++K +N+ + ++ A++ P C+C D P +C N + EC T CP +C+NQ F+ + ++ +F+T RG+GL+T I K +F+ EY+GELI + E R+ A++ + +FYM+ L D +IDAGPKGN +R+MNH C PNC + W VNG + G+FAL +I + ELTF+Y + + C C + NC+GFLG + +N I + E FK P K + E E+ C+ C D G LV C K CPK YH CL L + P+G W CPWH CD+CG+ + FC CP+SFC H +E + I + R S C H
Sbjct: 1441 ENVCQNCEKLGE---LLLCEAQCCGAFHLECL-GLPE-MPRGK--FICNECHTGIHTCFVCKQSG--EDVKRCLLPLCGKFYHEECVQK---YPPTVTQNKGFRCPLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRN-HEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKG---VDGTYKKALQEAA----ARFEELKAQKELRQLQEDRKNDKKPPPYKHIK-VNRPIGRVQIFTADLSEIPR----------CNCKATDENPCGIDSECINRMLLYECHPTVCPAGVRCQNQCFSKRQYPDVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLE-CLGNGKTVCKCGAPNCSGFLG-------------VRPKNQPI-------------------------------------VTEEKSRKFKRKPHG-------KRRSQGEVTKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDVCGKEAASFCEMCPSSFCKQH-REGMLFISKLDGRLS-CTEH 2103
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd1 (nuclear receptor-binding SET-domain protein 1 [Source:MGI Symbol;Acc:MGI:1276545]) HSP 1 Score: 411.379 bits (1056), Expect = 4.247e-121 Identity = 249/754 (33.02%), Postives = 368/754 (48.81%), Query Frame = 2
Query: 491 QSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDC--VDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKSICLLH 2728
++VC CE E +L C C FHL CL L E P K F C +C +GI+ C +C++ +D+ C CG+ YH+ C++ + NK CP H CI+C + +L+ C+RCP+++H ND C+AAG+ L+ + +ICP HF + N H+ + +WCF C + G L C+ CPA++H EC++ E + C +C+ ++P Y E+++VKV +YRWWP EI HPR P NI K+ G +PVLF GSN+Y W + R + SS K G +D + L+ A L LR + ++ PY ++K +N+ + ++ A++ P C+C D P +C N + EC T CP +C+NQ F+ + ++ +F+T RG+GL+T I K +F+ EY+GELI + E R+ A++ + +FYM+ L D +IDAGPKGN +R+MNH C PNC + W VNG + G+FAL +I + ELTF+Y + + C C + NC+GFLG + +N I + E FK P K + E E+ C+ C D G LV C K CPK YH CL L + P+G W CPWH CD+CG+ + FC CP+SFC H +E + I + R S C H
Sbjct: 1544 ENVCQNCEKLGE---LLLCEAQCCGAFHLECL-GLPE-MPRGK--FICNECHTGIHTCFVCKQSG--EDVKRCLLPLCGKFYHEECVQK---YPPTVTQNKGFRCPLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRN-HEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKG---VDGTYKKALQEAA----ARFEELKAQKELRQLQEDRKNDKKPPPYKHIK-VNRPIGRVQIFTADLSEIPR----------CNCKATDENPCGIDSECINRMLLYECHPTVCPAGVRCQNQCFSKRQYPDVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLE-CLGNGKTVCKCGAPNCSGFLG-------------VRPKNQPI-------------------------------------VTEEKSRKFKRKPHG-------KRRSQGEVTKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDVCGKEAASFCEMCPSSFCKQH-REGMLFISKLDGRLS-CTEH 2206
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd3 (nuclear receptor binding SET domain protein 3 [Source:MGI Symbol;Acc:MGI:2142581]) HSP 1 Score: 403.675 bits (1036), Expect = 9.418e-121 Identity = 252/761 (33.11%), Postives = 376/761 (49.41%), Query Frame = 2
Query: 494 SVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVD----NCPKQD---------CKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKSICLLH 2728
+VC VCE + ++ C G C R+FH+ CL + +F C +C +G + C C+ K D+ C S CG+ YH++C+ I ++K CP H C SC E + +++ CLRCP+++H D C+AAG+ +S +IC H + + + + +CF C + G L C CPAS+H EC+S E + C +C+ ++ Y ++++VK+ YRWWP EI PR+ P+NI L G +PV F GS++Y WV + R F + F E G T +++ F L A K Q + A + E L ++ ++K +K IKAN ++ KVQ + D + NC D C N +++ EC CP +C+NQ FT + + V KT RG+GL+T I K +F+ EY+GELI + E LR+ A + + +FYM+ +T D +IDAGPKGN SR+MNHSC+PNC + W VNG + G+FAL +I + ELTF+Y + + C C ++NC+GFLG P S + TS ++EK ++ + K + +EA K IHE++C++C DGG LV+CDK +CPK YHL CL L + P G W CPWH CD CG + FC CP SFC +H + ++P+ + C H
Sbjct: 712 TVCQVCE--KAGDCLVACEGECCRHFHVECLGLTA----VPEGHFTCEECETGQHPCFSCKVSGK--DVKRCSVSVCGKFYHEACVRK---FPTAIFESKGFRCPQHCCSSCSMEKDIHKASK-GRMMRCLRCPVAYHVGDACVAAGSVSVSSHILICSNHSK----RSSQSAAINVGFCFVCARGGRLLCCESCPASFHPECLSIDMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICSPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRV--FPYVEGDKHFAE--GQTSINKTFKKALEEAAKRFQ-------------ELKAQRESKEAL----EMERTSRKPPPYKHIKANKVIG------KVQVQVADLSEIPRCNCKPGDENPCGLESQCLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAEVIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLD-CLGNGRTVCHCGADNCSGFLG---VRPKS-------------ACTSAVDEK-----------TKNAKLKKRRKVKAEA-------------------------------KPIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPHGKWECPWHRCDECGSVAVSFCEFCPHSFCKAHGK--GALVPSALEGRLCCSSH 1368
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd3 (nuclear receptor binding SET domain protein 3 [Source:MGI Symbol;Acc:MGI:2142581]) HSP 1 Score: 387.497 bits (994), Expect = 1.032e-114 Identity = 254/806 (31.51%), Postives = 378/806 (46.90%), Query Frame = 2
Query: 494 SVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENK-----------------LVKLNAHKPFHPAWCFK----------------------------CFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVD----NCPKQD---------CKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKSICLLH 2728
+VC VCE + ++ C G C R+FH+ CL + +F C +C +G + C C+ K D+ C S CG+ YH++C+ I ++K CP H C SC E + +++ CLRCP+++H D C+AAG+ +S +IC H + L+ + P ++ +K C K G L C CPAS+H EC+S E + C +C+ ++ Y ++++VK+ YRWWP EI PR+ P+NI L G +PV F GS++Y WV + R F + F E G T +++ F L A K Q + A + E L ++ ++K +K IKAN ++ KVQ + D + NC D C N +++ EC CP +C+NQ FT + + V KT RG+GL+T I K +F+ EY+GELI + E LR+ A + + +FYM+ +T D +IDAGPKGN SR+MNHSC+PNC + W VNG + G+FAL +I + ELTF+Y + + C C ++NC+GFLG P S + TS ++EK ++ + K + +EA K IHE++C++C DGG LV+CDK +CPK YHL CL L + P G W CPWH CD CG + FC CP SFC +H + ++P+ + C H
Sbjct: 712 TVCQVCE--KAGDCLVACEGECCRHFHVECLGLTA----VPEGHFTCEECETGQHPCFSCKVSGK--DVKRCSVSVCGKFYHEACVRK---FPTAIFESKGFRCPQHCCSSCSMEKDIHKASK-GRMMRCLRCPVAYHVGDACVAAGSVSVSSHILICSNHSKRSSQSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLSESNRAELMKLPMIPSSSASKKRCEKGGRLLCCESCPASFHPECLSIDMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICSPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRV--FPYVEGDKHFAE--GQTSINKTFKKALEEAAKRFQ-------------ELKAQRESKEAL----EMERTSRKPPPYKHIKANKVIG------KVQVQVADLSEIPRCNCKPGDENPCGLESQCLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAEVIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLD-CLGNGRTVCHCGADNCSGFLG---VRPKS-------------ACTSAVDEK-----------TKNAKLKKRRKVKAEA-------------------------------KPIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPHGKWECPWHRCDECGSVAVSFCEFCPHSFCKAHGK--GALVPSALEGRLCCSSH 1417
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd3 (nuclear receptor binding SET domain protein 3 [Source:MGI Symbol;Acc:MGI:2142581]) HSP 1 Score: 387.497 bits (994), Expect = 1.032e-114 Identity = 254/806 (31.51%), Postives = 378/806 (46.90%), Query Frame = 2
Query: 494 SVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENK-----------------LVKLNAHKPFHPAWCFK----------------------------CFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVD----NCPKQD---------CKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKSICLLH 2728
+VC VCE + ++ C G C R+FH+ CL + +F C +C +G + C C+ K D+ C S CG+ YH++C+ I ++K CP H C SC E + +++ CLRCP+++H D C+AAG+ +S +IC H + L+ + P ++ +K C K G L C CPAS+H EC+S E + C +C+ ++ Y ++++VK+ YRWWP EI PR+ P+NI L G +PV F GS++Y WV + R F + F E G T +++ F L A K Q + A + E L ++ ++K +K IKAN ++ KVQ + D + NC D C N +++ EC CP +C+NQ FT + + V KT RG+GL+T I K +F+ EY+GELI + E LR+ A + + +FYM+ +T D +IDAGPKGN SR+MNHSC+PNC + W VNG + G+FAL +I + ELTF+Y + + C C ++NC+GFLG P S + TS ++EK ++ + K + +EA K IHE++C++C DGG LV+CDK +CPK YHL CL L + P G W CPWH CD CG + FC CP SFC +H + ++P+ + C H
Sbjct: 712 TVCQVCE--KAGDCLVACEGECCRHFHVECLGLTA----VPEGHFTCEECETGQHPCFSCKVSGK--DVKRCSVSVCGKFYHEACVRK---FPTAIFESKGFRCPQHCCSSCSMEKDIHKASK-GRMMRCLRCPVAYHVGDACVAAGSVSVSSHILICSNHSKRSSQSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLSESNRAELMKLPMIPSSSASKKRCEKGGRLLCCESCPASFHPECLSIDMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICSPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRV--FPYVEGDKHFAE--GQTSINKTFKKALEEAAKRFQ-------------ELKAQRESKEAL----EMERTSRKPPPYKHIKANKVIG------KVQVQVADLSEIPRCNCKPGDENPCGLESQCLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAEVIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLD-CLGNGRTVCHCGADNCSGFLG---VRPKS-------------ACTSAVDEK-----------TKNAKLKKRRKVKAEA-------------------------------KPIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPHGKWECPWHRCDECGSVAVSFCEFCPHSFCKAHGK--GALVPSALEGRLCCSSH 1417
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|O88491|NSD1_MOUSE (Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Mus musculus OX=10090 GN=Nsd1 PE=1 SV=1) HSP 1 Score: 410.994 bits (1055), Expect = 3.886e-120 Identity = 249/754 (33.02%), Postives = 368/754 (48.81%), Query Frame = 2
Query: 491 QSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDC--VDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKSICLLH 2728
++VC CE E +L C C FHL CL L E P K F C +C +GI+ C +C++ +D+ C CG+ YH+ C++ + NK CP H CI+C + +L+ C+RCP+++H ND C+AAG+ L+ + +ICP HF + N H+ + +WCF C + G L C+ CPA++H EC++ E + C +C+ ++P Y E+++VKV +YRWWP EI HPR P NI K+ G +PVLF GSN+Y W + R + SS K G +D + L+ A L LR + ++ PY ++K +N+ + ++ A++ P C+C D P +C N + EC T CP +C+NQ F+ + ++ +F+T RG+GL+T I K +F+ EY+GELI + E R+ A++ + +FYM+ L D +IDAGPKGN +R+MNH C PNC + W VNG + G+FAL +I + ELTF+Y + + C C + NC+GFLG + +N I + E FK P K + E E+ C+ C D G LV C K CPK YH CL L + P+G W CPWH CD+CG+ + FC CP+SFC H +E + I + R S C H
Sbjct: 1441 ENVCQNCEKLGE---LLLCEAQCCGAFHLECL-GLPE-MPRGK--FICNECHTGIHTCFVCKQSG--EDVKRCLLPLCGKFYHEECVQK---YPPTVTQNKGFRCPLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRN-HEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKG---VDGTYKKALQEAA----ARFEELKARKELRQLQEDRKNDKKPPPYKHIK-VNRPIGRVQIFTADLSEIPR----------CNCKATDENPCGIDSECINRMLLYECHPTVCPAGVRCQNQCFSKRQYPDVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLE-CLGNGKTVCKCGAPNCSGFLG-------------VRPKNQPI-------------------------------------VTEEKSRKFKRKPHG-------KRRSQGEVTKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDVCGKEAASFCEMCPSSFCKQH-REGMLFISKLDGRLS-CTEH 2103
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|Q6P2L6|NSD3_MOUSE (Histone-lysine N-methyltransferase NSD3 OS=Mus musculus OX=10090 GN=Nsd3 PE=1 SV=2) HSP 1 Score: 382.104 bits (980), Expect = 6.554e-112 Identity = 254/809 (31.40%), Postives = 378/809 (46.72%), Query Frame = 2
Query: 494 SVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENK-----------------LVKLNAHKPFHPAWCFK----------------------------CFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYR---WWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVD----NCPKQD---------CKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKSICLLH 2728
+VC VCE + ++ C G C R+FH+ CL + +F C +C +G + C C+ K D+ C S CG+ YH++C+ I ++K CP H C SC E + +++ CLRCP+++H D C+AAG+ +S +IC H + L+ + P ++ +K C K G L C CPAS+H EC+S E + C +C+ ++ Y ++++VK+ YR WWP EI PR+ P+NI L G +PV F GS++Y WV + R F + F E G T +++ F L A K Q + A + E L ++ ++K +K IKAN ++ KVQ + D + NC D C N +++ EC CP +C+NQ FT + + V KT RG+GL+T I K +F+ EY+GELI + E LR+ A + + +FYM+ +T D +IDAGPKGN SR+MNHSC+PNC + W VNG + G+FAL +I + ELTF+Y + + C C ++NC+GFLG P S + TS ++EK ++ + K + +EA K IHE++C++C DGG LV+CDK +CPK YHL CL L + P G W CPWH CD CG + FC CP SFC +H + ++P+ + C H
Sbjct: 702 TVCQVCE--KAGDCLVACEGECCRHFHVECLGLTA----VPEGHFTCEECETGQHPCFSCKVSGK--DVKRCSVSVCGKFYHEACVRK---FPTAIFESKGFRCPQHCCSSCSMEKDIHKASK-GRMMRCLRCPVAYHVGDACVAAGSVSVSSHILICSNHSKRSSQSAAINVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLSESNRAELMKLPMIPSSSASKKRCEKGGRLLCCESCPASFHPECLSIDMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRQVLWWPAEICSPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRV--FPYVEGDKHFAE--GQTSINKTFKKALEEAAKRFQ-------------ELKAQRESKEAL----EMERTSRKPPPYKHIKANKVIG------KVQVQVADLSEIPRCNCKPGDENPCGLESQCLNRMSQYECHPQVCPAGDRCQNQCFTKRLYPDAEVIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLD-CLGNGRTVCHCGADNCSGFLG---VRPKS-------------ACTSAVDEK-----------TKNAKLKKRRKVKAEA-------------------------------KPIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPHGKWECPWHRCDECGSVAVSFCEFCPHSFCKAHGK--GALVPSALEGRLCCSSH 1410
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|Q96L73|NSD1_HUMAN (Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=1) HSP 1 Score: 341.658 bits (875), Expect = 9.214e-97 Identity = 198/572 (34.62%), Postives = 301/572 (52.62%), Query Frame = 2
Query: 491 QSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDC--VDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
++VC CE E +L C C FHL CL L E P K F C +C +GI+ C +C++ +D+ C CG+ YH+ C++ + NK C H CI+C + +L+ C+RCP+++H ND C+AAG+ L+ + +ICP HF + N H+ + +WCF C + G L C+ CPA++H EC++ E + C +C+ ++P Y E+++VKV +YRWWP EI HPR P NI K+ G +PVLF GSN+Y W + R + SS K G +D + L+ A L LR + ++ PY ++K +N+ + ++ A++ P C+C D P +C N + EC T CP +C+NQ F+ + + +F+T RG+GL+T I K +F+ EY+GELI + E R+ A++ + +FYM+ L D +IDAGPKGN +R+MNH C PNC + W VNG + G+FAL +I + ELTF+Y + + C C + NC+GFLG
Sbjct: 1543 ENVCQNCEKLGE---LLLCEAQCCGAFHLECL-GLTE-MPRGK--FICNECRTGIHTCFVCKQSG--EDVKRCLLPLCGKFYHEECVQK---YPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRN-HEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKG---VDGTYKKALQEAA----ARFEELKAQKELRQLQEDRKNDKKPPPYKHIK-VNRPIGRVQIFTADLSEIPR----------CNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLE-CLGNGKTVCKCGAPNCSGFLG 2082 HSP 2 Score: 95.1301 bits (235), Expect = 3.073e-18 Identity = 43/91 (47.25%), Postives = 53/91 (58.24%), Query Frame = 2
Query: 2456 HENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKSICLLH 2728
E+ C+ C D G LV C K CPK YH CL L + P+G W CPWH CDICG+ + FC CP+SFC H +E + I + R S C H
Sbjct: 2117 REDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQH-REGMLFISKLDGRLS-CTEH 2205
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|O96028|NSD2_HUMAN (Histone-lysine N-methyltransferase NSD2 OS=Homo sapiens OX=9606 GN=NSD2 PE=1 SV=1) HSP 1 Score: 325.865 bits (834), Expect = 2.250e-92 Identity = 189/590 (32.03%), Postives = 307/590 (52.03%), Query Frame = 2
Query: 449 EIQRLVASPAQYSFQSVCA----VCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDC--VDNCP---KQDCKNYLNKIECQITQCPK---CKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
E Q V+ ++ S + V A VC++ + ++L C G C FHL CL + +P + F C +C SGI+ C +C+ + D+ C + CG+ YH++C++ + + +++ CP H C+SC + + + K++ C+RCP+++H D C+AAG ++ + +IC HF + K + H + +WCF C K G L C CPA++H +C++ + + C +CR ++ + ++++VK+ YRWWP E+ HP+N P NI K+ G +PV F GS +Y W + R + S ++ G + R F + L+ A + I L R + + + PY ++K +N+ K ++ A+I P C+C D P +C N + EC CP C+NQ FT + + KT +G+GL I K +F+ EY+GELI + E R+ +A + + FYM+ + D +IDAGPKGN SR+MNHSC PNC W VNG + G+FA+ +I + ELTF+Y + + E C C ++NC+GFLG
Sbjct: 646 ETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSR--RPEGR--FTCSECASGIHSCFVCK--ESKTDVKRCVVTQCGKFYHEACVKK---YPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRH-HAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQ---GVRGIGRVFKNALQEA---EARFREIKLQ----REARETQESERKPPPYKHIK-VNKPYGKVQIYTADISEIPK----------CNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLD-CLGNEKTVCRCGASNCSGFLG 1203 HSP 2 Score: 107.457 bits (267), Expect = 3.893e-22 Identity = 46/79 (58.23%), Postives = 52/79 (65.82%), Query Frame = 2
Query: 2441 ESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQET 2677
E K E+ C+RC DGG LVLCD+ C K YHLSCLGL + P G W CPWH CD+CG+PS FC CP SFC H T
Sbjct: 1233 EGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGT 1311
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|Q8BVE8|NSD2_MOUSE (Histone-lysine N-methyltransferase NSD2 OS=Mus musculus OX=10090 GN=Nsd2 PE=1 SV=2) HSP 1 Score: 322.398 bits (825), Expect = 3.010e-91 Identity = 196/625 (31.36%), Postives = 319/625 (51.04%), Query Frame = 2
Query: 350 SPSPNLKKYR-KDSLHNENSVIKIE-----KESVPIFQMEIQRLVASPAQYSFQSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDC--VDNCP---KQDCKNYLNKIECQITQCPK---CKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
SPS +L ++ DS +E S E + + + +R +A+ +Y VC +CE + ++L C G C FHL CL + +P + F C +C SGI+ C +C++ ++ C + CG+ YH++C++ + + +++ CP H C+SC + + + K++ C+RCP+++H D C+AAG ++ + +IC HF + K + H + +WCF C K G L C CPA++H +C++ + + C +CR ++ + ++++VK+ YRWWP E+ HP+N P NI K+ G +PV F GS +Y W + R + S ++ G + R F + L+ A + N + + R S PY ++K +N+ K ++ A+I P C+C D P +C N + EC CP C+NQ FT + + KT +G+GL I K +F+ EY+GELI + E R+ A + + FYM+ + D +IDAGPKGN SR+MNHSC PNC W VNG + G+FA+ +I + ELTF+Y + + E C C ++NC+GFLG
Sbjct: 618 SPSASLTEHEVSDSPGDEPSESPYESADETQTEASVSSKKSERGMAAKKEY----VCQLCE---KTGSLLLCEGPCCGAFHLACLGLSR--RPEGR--FTCTECASGIHSCFVCKESKM--EVKRCVVNQCGKFYHEACVKK---YPLTVFESRGFRCPLHSCMSCHASNPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTARKGKRH-HTHVNVSWCFVCSKGGSLLCCEACPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQ---GVRGIGRVFKNALQEA----EARFNEVKLQREARETQESERKPP---PYKHIK-VNKPYGKVQIYTADISEIPK----------CNCKPTDENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLD-CLGNEKTVCRCGASNCSGFLG 1203 HSP 2 Score: 107.457 bits (267), Expect = 4.097e-22 Identity = 46/79 (58.23%), Postives = 52/79 (65.82%), Query Frame = 2
Query: 2441 ESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQET 2677
E K E+ C+RC DGG LVLCD+ C K YHLSCLGL + P G W CPWH CD+CG+PS FC CP SFC H T
Sbjct: 1233 EGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGT 1311
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A075AHA7 (Uncharacterized protein (Fragment) OS=Opisthorchis viverrini OX=6198 GN=T265_13347 PE=4 SV=1) HSP 1 Score: 524.628 bits (1350), Expect = 8.491e-165 Identity = 315/955 (32.98%), Postives = 480/955 (50.26%), Query Frame = 2
Query: 197 KNDAGKSLEVEGKARCEWSNLRLNEKKSFIKSFKIDENDHRKSIKSRKPQR--------SPSPNLKKYRKDSLHNENSVIKIEKESVPI------FQMEIQRLVASPAQYSFQSVCAVCEIYTE-NNAVLQCTGICKRYFHLHCL--KNLKENQPTSKPNFQCLDCFSGIYHCILCQKV------DKIDDLLACENSDCGRLYHKSC-LEMSNFI---GIEIHDN------KILSCPSHYCISCVREDATFAQNPCKK---LVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKT--GVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVN-ILLMHVPLRSISASSMTAEELYP----------YVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVDNCP---------------KQDCKNYLNKIECQITQCP----KCKNQQFTNV----DHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNA--------------KDFYMIHLTGDL--VIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYR----ISGVIMKEDAFCLCSSNNCTGFLGPIKS-------LPNSPVKSQ--LTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISK-------AIDLISEA--------------PILNESFESFKDIPLNALEEKFIKDKDSVES--KTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIII 2689
KN + +E + + +W ++ K+S++++ + S +S +P+R +P P LKK + ++ + K S +EI RL+ SPAQY +Q VC CE+Y+ +++C G C R H C+ K F+C +C SG Y C +C K ++ L C DCGR +H+ C LE + + H +++ CP+H C +C E A P L++C+RCP +FH DLC AG+ E+SLSH++CP+H+E+ LV + K HP WCF+CF T K+ C CPA+YH EC + ++C +CRN PRY ++++ K+ +RWWPCEIIH RNAP+NIL + P+GT+PV FLGS+EYQWVA+ + + SS K+S GT +++ F+ L+ A K +Q+YVN +L +PL S+ A + EEL P + +++E ++ +L + + P KL PK+ I V + P K C + N+ +C C C N++F + + + +F+T NRGFGLK D + EY+GE+IT +++ R+L A NA + Y+ L+ DL V+DA +GNLSR++NHSC+PN +NW+ P G+FALK I ++ELT DYR +S +M + CLC ++ C L KS + PV SQ + R S + S + S+ LS ++ +++ + L++ A P + + L A + D+ ++ HE+FCYRC DGG L+LCDK +CPK++HL+CLGL PSG WYCPWH+CD CG PS C RCP S+C HA ++ I +
Sbjct: 29 KNPDLDRVALEEELKAQWPAFDISTKRSYLQN---KLGLFQSSAQSDRPKRKSSVSIEFTPKPCLKKSKDETSATKPHKKKPTDGSAKSGDEPRELDIEIHRLIVSPAQYRWQPVCPACEVYSNVPGQMVKCLGPCGRLVHPSCMRYKTPPPPDNNRPDKFKCSECLSGDYLCTICGKPADPKAKGNLNCLYLCPVRDCGRHFHRDCALEWPGTVCRPSLSEHKTSRSSAFQLIRCPAHCCQTCWLERDPSAPQPTTSETPLLQCVRCPAAFHTGDLCTPAGSVEVSLSHIVCPRHYEDTLVSTHGFKTQHPNWCFQCFNTIAADKVLCQTCPATYHKECSQSAPNDGNFICQSCRNGVFPRYAQIIWAKIMHFRWWPCEIIHARNAPINILNMTHPEGTFPVHFLGSDEYQWVARGAVLPYEIGLKSSAAKDSHGTKSVEKAFTRALKRAPKAYQLYVNHVLKRGLPLTSMHADPLPDEELLPPASMDADVGIHPSLEEESKALALAELTPLHSSIFPEKLWPKLHKLITSRVPSSPCSCATSSSTNTMCSNKSGCIHVRNRADCASAVCSFGTKDCGNRRFAQMLLTSEADRVTLFRTVNRGFGLKANKSFKSGDLVTEYVGEIITLDDANKRILEALGPNALANISSSRKGFQPLAETYLARLSSDLDFVVDAHKQGNLSRFINHSCEPNLQADNWLTGEKPHVGLFALKAIAPNEELTVDYRTSQFLSTGLMGAASLCLCGADTCASTLNLPKSFESVQSHVAEVPVSSQSAINERRKSKAKGSASETPADTNASRGSLSTTNEEVAEQKPQAFSVVSLLAAASTHASARRDRALIQPTTAAARAAMSKAKLPAPQPDIAHDQYALLGLRPPPHEDFCYRCGDGGELLLCDKSSCPKSFHLNCLGLSSPPSGIWYCPWHYCDQCGHPSTHLCWRCPNSYCLDHALDSKIEV 980
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A4S2LAE9 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_009922 PE=4 SV=1) HSP 1 Score: 522.316 bits (1344), Expect = 2.839e-162 Identity = 319/959 (33.26%), Postives = 485/959 (50.57%), Query Frame = 2
Query: 218 LEVEGKARCEWSNLRLNEKKSFIKS----FKID-ENDHRKSIKSRKPQRSPSPNLKKYRKDSLHNENSVIKIEKESVPI------------FQMEIQRLVASPAQYSFQSVCAVCEIYTE-NNAVLQCTGICKRYFHLHCL--KNLKENQPTSKPNFQCLDCFSGIYHCILCQKV------DKIDDLLACENSDCGRLYHKSC-LEMSNFI---GIEIHDN------KILSCPSHYCISCVREDATFAQNPCKK---LVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKT--GVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVN-ILLMHVPLRSISASSMTAEELYP----------YVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVDNCP---------------KQDCKNYLNKIECQITQCP----KCKNQQFTNV----DHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNA--------------KDFYMIHLTGDL--VIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYR----ISGVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESF-----ESFKDIPLNALEEKFI---KDKDSVESKTI--------------------------------HENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIII 2689
+ +E + + +W ++ K+S++++ F+ ++D K S + +P P LKK ++ E S IK K+ P +EI RL+ SPAQY +Q VC CE+Y+ +++C G C R H C+ K F+C +C SG Y C +C K ++ L C DCGR +H+ C LE + + H +++ CP+H C +C E A P L++C+RCP +FH DLC AG+ E+SLSH++CP+H+E+ LV + K HP WCF+CF T K+ C CPA+YH EC + ++C +CRN PRY ++++ K+ +RWWPCEIIH RNAP+NIL + P+GT+PV FLGS+EYQWVA+ + + SS K+S GT +++ F+ L+ A K +Q+YVN +L +PL S+ A + EEL P + +++E ++ +L + + P KL PK+ I V + P K C + N+ +C C C N++F + + + +F+T NRGFGLK D + EY+GE+IT +++ R+L A NA + Y+ L+ DL V+DA +GNLSR++NHSC+PN E+W+ P G+FALK I ++ELT DYR +S +M + CLC ++ C L KS + V+SQ+T + +S S INE+ +K S+ + + ++++ NE ++F + L A +D+ ++ T HE+FCYRC DGG L+LCDK +CPK++HL+CLGL PSG WYCPWH+CD CG PS C RCP S+C HA ++ I +
Sbjct: 187 VALEEELKAQWPAFDISTKRSYLQNKLGLFQSSAQSDRPKRKSSMAIEFTPKPCLKKAKE-----ETSGIKTHKKK-PTDGSAKSGDEPRELDIEIHRLIVSPAQYRWQPVCPACEVYSNVPGQMVKCLGPCGRLVHPSCMRYKTPPPPDNNRPDKFKCSECLSGDYLCTICGKPADPKAKGNLNCLYLCPVRDCGRHFHRDCVLEWPGTVCRPSLSEHKTSRSSAFQLIRCPAHCCQTCWLERDPSAPQPTTSENPLLQCVRCPAAFHTGDLCTPAGSAEVSLSHIVCPRHYEDTLVSAHGFKTQHPNWCFQCFNTIAADKVLCQTCPATYHKECNQSAPNDGNFICQSCRNGVFPRYAQIIWAKIMHFRWWPCEIIHARNAPINILNMTHPEGTFPVHFLGSDEYQWVARGAVLPYEIGLKSSAAKDSHGTKSVEKAFTRALKRAPKAYQLYVNHVLKRGLPLTSMHADPLPDEELLPPASMDADVGIHPSLEEESKALALAELTPLHSTIFPEKLWPKLHKLITSRVPSSPCSCATSSTTNTMCSNKSGCIHVRNRADCASAVCSFGTKDCGNRRFAQMLLTSETDRVTLFRTVNRGFGLKANKSFKPGDLVTEYVGEIITLDDANQRILEALGPNALANISSSRKGFQPLAETYLARLSSDLDFVVDAHKQGNLSRFINHSCEPNLLAESWLTGDKPHVGLFALKTIAPNEELTVDYRASQFLSTGLMGAASLCLCGADTCASTLNLPKSFDS--VQSQVT--DVPVSSQSAINER-RKSKAKGSASETPVDTNAGRGSLNKSRTANEEVAEQKPQAFSVVSLLAAASTHASARRDRALIQPTTAAARAAMSKAKIPVTQSDIAHDQYALLGLRPPPHEDFCYRCGDGGELLLCDKSSCPKSFHLNCLGLSSPPSGIWYCPWHYCDQCGHPSTHLCWRCPNSYCLEHALDSKIEV 1134
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: G7YW68 (Probable histone-lysine N-methyltransferase NSD2 OS=Clonorchis sinensis OX=79923 GN=CLF_112319 PE=4 SV=1) HSP 1 Score: 519.235 bits (1336), Expect = 3.612e-161 Identity = 315/952 (33.09%), Postives = 478/952 (50.21%), Query Frame = 2
Query: 218 LEVEGKARCEWSNLRLNEKKSFIKSFKIDENDHRKSIKSRKPQRSPSPNLKKYRKDSLH---NENSVIKIEKESVPI------------FQMEIQRLVASPAQYSFQSVCAVCEIYTE-NNAVLQCTGICKRYFHLHCL--KNLKENQPTSKPNFQCLDCFSGIYHCILCQKV------DKIDDLLACENSDCGRLYHKSC-LEMSNFI---GIEIHDN------KILSCPSHYCISCVREDATFAQNPCKK---LVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKT--GVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVN-ILLMHVPLRSISASSMTAEELYP----------YVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVDNCP---------------KQDCKNYLNKIECQITQCP----KCKNQQFTNV----DHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNA--------------KDFYMIHLTGDL--VIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYR----ISGVIMKEDAFCLCSSNNCTGFLGPIKS-------LPNSPVKSQ--LTSRNSSISLTSGINEKPLVDISKDDLSK----------QDDNISKAIDLISEA--------------PILNESFESFKDIPLNALEEKFIKDKDSVES--KTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIII 2689
+ +E + + +W ++ K+S++++ + S +S +P+R S +++ K L +E S IK K+ P +EI RL+ SPAQY +Q VC CE+Y+ +++C G C R H C+ K F+C +C SG Y C +C K ++ L C DCGR +H+ C LE + + H +++ CP+H C +C E A P L++C+RCP +FH DLC AG+ E+SLSH++CP+H+E+ LV + K HP WCF+CF T K+ C CPA+YH EC + ++C +CRN PRY ++++ K+ +RWWPCEIIH RNAP+NIL + P+GT+PV FLGS+EYQWVA+ + + SS K+S GT +++ F+ L+ A K +Q+YVN +L +PL S+ A + EEL P + +++E ++ +L + + P KL PK+ I V + P K C + N+ +C C C N++F + + + +F+T NRGFGLK D + EY+GE+IT +++ R+L A NA + Y+ L+ DL V+DA +GNLSR++NHSC+PN ++W+ P G+FALK I ++ELT DYR +S +M + CLC ++ C L KS + + PV SQ + R S + S + S+ L+K Q + L++ A P + + L A + D+ ++ HE+FCYRC DGG L+LCDK +CPK++HL+CLGL PSG WYCPWH+CD CG PS C RCP S+C HA ++ I +
Sbjct: 187 VALEEELKAQWPAFDISTKRSYLQN---KLGLFQSSAQSDRPKRKSSMSIEFTPKSCLKKAKDETSGIKTHKKK-PTDGSAKSGDEPRELDIEIHRLIVSPAQYRWQPVCPACEVYSNVPGQMVKCLGPCGRLVHPSCMRYKTPPPPDNNRPDKFKCSECLSGDYLCTVCGKPADPKAKGNLNCLYLCPVRDCGRHFHRECVLEWPGTVCRPSLSEHKTSRSSAFQLIRCPAHCCQTCWLERDPSAPQPTTSETPLLQCVRCPAAFHTGDLCTPAGSAEVSLSHIVCPRHYEDTLVSAHGFKTQHPNWCFQCFNTIAADKVLCQTCPATYHKECSQSAPNDGNFICQSCRNGVFPRYAQIIWAKIMHFRWWPCEIIHARNAPINILNMTHPEGTFPVHFLGSDEYQWVARGAVLPYEIGLKSSAAKDSHGTKSVEKAFTRALKRAPKAYQLYVNHVLKRGLPLTSMHADPLPDEELLPPASMEADVGIHPSLEEESKALALAELTPLHSSIFPEKLWPKLHKLITSRVPSSPCSCATSSSTNTMCSNKSGCIHVRNRADCASAVCSFGTKDCGNRRFAQMLLTPETDRVTLFRTVNRGFGLKANKSFKSGDLVTEYVGEIITLDDANKRILEALGPNALANISSSRKGFQPLAETYLARLSSDLDFVVDAHKQGNLSRFINHSCEPNLLADSWLTGEKPHVGLFALKTIAPNEELTVDYRASQFLSTGLMGAASLCLCGADTCASTLNLPKSFDSVQSHVTDVPVSSQSAINERRKSKAKGSASESPADTNASRGSLNKSRTTNEEVAEQKPQAFSVVSLLAAASTHASARRDRALIQPTTAAARAAMSKAKLPAPQSDIAHDQYTLLGLRPPPHEDFCYRCGDGGELLLCDKSSCPKSFHLNCLGLSSPPSGIWYCPWHYCDQCGHPSTHLCWRCPNSYCLEHALDSKIEV 1134
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A419PQA4 (Histone-lysine N-methyltransferase OS=Clonorchis sinensis OX=79923 GN=Nsd1 PE=4 SV=1) HSP 1 Score: 519.62 bits (1337), Expect = 7.184e-160 Identity = 315/952 (33.09%), Postives = 478/952 (50.21%), Query Frame = 2
Query: 218 LEVEGKARCEWSNLRLNEKKSFIKSFKIDENDHRKSIKSRKPQRSPSPNLKKYRKDSLH---NENSVIKIEKESVPI------------FQMEIQRLVASPAQYSFQSVCAVCEIYTE-NNAVLQCTGICKRYFHLHCL--KNLKENQPTSKPNFQCLDCFSGIYHCILCQKV------DKIDDLLACENSDCGRLYHKSC-LEMSNFI---GIEIHDN------KILSCPSHYCISCVREDATFAQNPCKK---LVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKT--GVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVN-ILLMHVPLRSISASSMTAEELYP----------YVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVDNCP---------------KQDCKNYLNKIECQITQCP----KCKNQQFTNV----DHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNA--------------KDFYMIHLTGDL--VIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYR----ISGVIMKEDAFCLCSSNNCTGFLGPIKS-------LPNSPVKSQ--LTSRNSSISLTSGINEKPLVDISKDDLSK----------QDDNISKAIDLISEA--------------PILNESFESFKDIPLNALEEKFIKDKDSVES--KTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIII 2689
+ +E + + +W ++ K+S++++ + S +S +P+R S +++ K L +E S IK K+ P +EI RL+ SPAQY +Q VC CE+Y+ +++C G C R H C+ K F+C +C SG Y C +C K ++ L C DCGR +H+ C LE + + H +++ CP+H C +C E A P L++C+RCP +FH DLC AG+ E+SLSH++CP+H+E+ LV + K HP WCF+CF T K+ C CPA+YH EC + ++C +CRN PRY ++++ K+ +RWWPCEIIH RNAP+NIL + P+GT+PV FLGS+EYQWVA+ + + SS K+S GT +++ F+ L+ A K +Q+YVN +L +PL S+ A + EEL P + +++E ++ +L + + P KL PK+ I V + P K C + N+ +C C C N++F + + + +F+T NRGFGLK D + EY+GE+IT +++ R+L A NA + Y+ L+ DL V+DA +GNLSR++NHSC+PN ++W+ P G+FALK I ++ELT DYR +S +M + CLC ++ C L KS + + PV SQ + R S + S + S+ L+K Q + L++ A P + + L A + D+ ++ HE+FCYRC DGG L+LCDK +CPK++HL+CLGL PSG WYCPWH+CD CG PS C RCP S+C HA ++ I +
Sbjct: 334 VALEEELKAQWPAFDISTKRSYLQN---KLGLFQSSAQSDRPKRKSSMSIEFTPKSCLKKAKDETSGIKTHKKK-PTDGSAKSGDEPRELDIEIHRLIVSPAQYRWQPVCPACEVYSNVPGQMVKCLGPCGRLVHPSCMRYKTPPPPDNNRPDKFKCSECLSGDYLCTVCGKPADPKAKGNLNCLYLCPVRDCGRHFHRECVLEWPGTVCRPSLSEHKTSRSSAFQLIRCPAHCCQTCWLERDPSAPQPTTSETPLLQCVRCPAAFHTGDLCTPAGSAEVSLSHIVCPRHYEDTLVSAHGFKTQHPNWCFQCFNTIAADKVLCQTCPATYHKECSQSAPNDGNFICQSCRNGVFPRYAQIIWAKIMHFRWWPCEIIHARNAPINILNMTHPEGTFPVHFLGSDEYQWVARGAVLPYEIGLKSSAAKDSHGTKSVEKAFTRALKRAPKAYQLYVNHVLKRGLPLTSMHADPLPDEELLPPASMEADVGIHPSLEEESKALALAELTPLHSSIFPEKLWPKLHKLITSRVPSSPCSCATSSSTNTMCSNKSGCIHVRNRADCASAVCSFGTKDCGNRRFAQMLLTPETDRVTLFRTVNRGFGLKANKSFKSGDLVTEYVGEIITLDDANKRILEALGPNALANISSSRKGFQPLAETYLARLSSDLDFVVDAHKQGNLSRFINHSCEPNLLADSWLTGEKPHVGLFALKTIAPNEELTVDYRASQFLSTGLMGAASLCLCGADTCASTLNLPKSFDSVQSHVTDVPVSSQSAINERRKSKAKGSASESPADTNASRGSLNKSRTTNEEVAEQKPQAFSVVSLLAAASTHASARRDRALIQPTTAAARAAMSKAKLPAPQSDIAHDQYTLLGLRPPPHEDFCYRCGDGGELLLCDKSSCPKSFHLNCLGLSSPPSGIWYCPWHYCDQCGHPSTHLCWRCPNSYCLEHALDSKIEV 1281
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A5K3EIB1 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1) HSP 1 Score: 502.286 bits (1292), Expect = 3.343e-157 Identity = 303/917 (33.04%), Postives = 467/917 (50.93%), Query Frame = 2
Query: 218 LEVEGKARCEWSNLRLNEKKSFIKS----------FKID-----ENDHRKSIKSRKPQRSPSPNLKKYRKDSLHNENSVIKIEKESVPIFQMEIQRLVASPAQYSFQSVCAVCEIYTEN-NAVLQCTGICKRYFHLHCLKNLKENQP-TSKPN-FQCLDCFSGIYHCILC----QKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDA-TFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGV-KLHCNYCPASYHIECVSD-----YSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMH-VPLRSISASSMTAEELYPY----------------VNVKEINQKTVKFKLIKANIIVPPA--KLPPKVQPSI-CDCVDN-----CPKQ-DCKNYLNKIECQITQCP--------KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRM----------------LNAKKFNAKDF---YMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVI----MKEDAFCLCSSNNCTGFLGPIKSLPNS---PVKSQLTSRNSSISLTSGINEKPL----------VDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQ 2671
LE++ R +W + K+S++ + FK+D RKS+ S P K + D + K+E +EI RL+ASPA + FQ VC VCE+Y+ +L+C G C R H C++ + +P +P F+C C + Y C +C +K + D LL C+ CGR +H+ CL + G+ + D + CP+H C +C ED +P + +++C+RCP +H DLC AG+ E+SLSH++CP HF ++L + +K PAWCF C K G ++ C CP +YH C+ + SEES + C NCR +PRY +V++ K+ +RWWPCEIIH RNAP+NI L P+GT+ + F+GS EYQWV + ++ + +S + ++ D F+ ++A K+H+ YVN + +PLRS+SA+ ++ EEL P + ++ + F+ + +N A KL + P CDC + C K+ +C+N IEC C C N+ F+ ++AVF+T+NRGFGLK + + F++E++GE+I E+ R+ + +F ++ Y+I T +LVIDA GNL+R++NHSC+PN + W V G + G+FAL + ELT DY+ + ++ + CLC +++C G L LP+S P K+ +N++ ++ S NEK SK + + L + A + + + +P K ++ K S K+ H++FCYRC DGG L+LCDK +CPK YHL CLGL P G W+CPWH+CD CG PS C RCP S+C HA+
Sbjct: 37 LELDNALRIQWPAFDIATKRSYLSNKLEMLNLESEFKMDHSRTTRGAGRKSVLSTDESSGMKPTPKANKSDKPKKQKPREKLE------LDLEIHRLIASPAPFRFQPVCPVCEVYSSAPGQMLKCNGPCGRIVHPRCMRYKEPPKPENQRPEIFKCPQCLTQKYLCAVCGDSSKKTNTDDQLLPCQMKGCGRHFHRGCL--AQHPGVVLADT-LSRCPAHVCATCCLEDPDNVVVDPNRPMLQCVRCPRVYHTGDLCTPAGSVEVSLSHIVCPAHFSSQLSEDQHYKTQWPAWCFACLKAGADRVFCKTCPFNYHRTCLPEDEQVGVSEESTFTCKNCRQHIEPRYAQVVWAKIPFFRWWPCEIIHARNAPLNIFNLAHPEGTFLIHFIGSGEYQWVCRAQTFPYECGLNTSAAVLAKSNSKKDVAFNLSAKMAPKVHEFYVNYVWKRGIPLRSMSATRLSDEELVPLSTPETAIALGLTPHQDTDAVQLAEALSSFQQVVSNQYANSALEKLAKQELPETKCDCAKSETETHCSKETECRNASEGIECTDQVCSVLAHNPSVDCGNRPFSV--QPSLAVFRTTNRGFGLKVLENVKEGSFVVEFMGEVIGVEEANRRLEASIAARAAHRGHQGSTSQSRFTSETMPTTYLIRFTPELVIDAEKLGNLARFVNHSCEPNLVAKLWNVRGTLRMGLFALSPLSEQDELTLDYQQANLLDSSFVGNRNICLCGADSCQGSL----HLPSSFHCPEKA----KNATPAVASKSNEKGADQVVEVQVVEEPKSKRGRKSAGGGANMSQLLSAAASVDVKPQKKVVAVPTVGPSPKVVETKPS--KKSSHDDFCYRCGDGGELILCDKSSCPKAYHLGCLGLVRPPFGIWFCPWHYCDDCGNPSSHLCWRCPNSYCLEHAE 932
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581]) HSP 1 Score: 335.495 bits (859), Expect = 1.195e-96 Identity = 193/578 (33.39%), Postives = 303/578 (52.42%), Query Frame = 2
Query: 476 AQYSFQSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVA-GKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDC--VDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
A +SVC VCE +E+ ++ C G C +HL CL + PT K C C +G++ C C++ + ++ C CG+ YH++CL +S + + DN+ CP H C+SC + A+ K++ CLRCP+++H DLC+AAG+ L+ + ++C HF N + H + +WCF C K G L C CPA++H +C++ + + C +CR+ ++P+Y ++++VK+ YRWWP EI HPRN P NI L G +PV F GS +Y W + R + S + +G + + F + L A + Q+ + R + ++ PY +K N+ + ++ A+I P C+C D P + +C N + EC CP +C NQ FT + +T+ +G+GL T I K +F+ EY+GELI + E R+ A++ + FYM+ + D +IDAGPKGN SR+MNHSC PNC + W VNG + G+FA+ +I + ELTF+Y + + E C C + NC+GFLG
Sbjct: 678 ASVKKESVCQVCEKTSED--LVTCEGHCFATYHLQCLG---LDHPTDK--VLCTACRTGVHACFTCKQSE--GEVKRCSVLHCGKYYHEACLRLS---ALTVFDNRGFRCPLHTCLSCHYSNRGTAKATKGKMIRCLRCPVAYHAGDLCVAAGSEMLTSTAIVCTNHF-NPKKGYSHHSHVNVSWCFICSKGGRLLCCESCPAAFHPDCLNIAMPDGSWFCNDCRSGKKPKYRDIIWVKLGNYRWWPAEIRHPRNIPTNIQHLRHEIGEFPVYFFGSKDYFWTHQGRVFPYIEGDRGSRHQRNG----IGKVFKTALLEAETRFKQIKME--------REAKEAHENNKKPPPYKYIK-TNKPCGRVQIYTADISEIPK----------CNCKPTDERPCSFESECLNRMLLYECHPQVCPAGERCMNQDFTKRLYPETKTIRTAGKGWGLLTLRDIKKGEFVNEYVGELIDEEECRARIRYAQENDITHFYMLTINKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCDIPTGTELTFNYNLD-CLGNEKTVCRCGAPNCSGFLG 1218 HSP 2 Score: 106.686 bits (265), Expect = 7.000e-23 Identity = 49/96 (51.04%), Postives = 57/96 (59.38%), Query Frame = 2
Query: 2441 ESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKSICLLH 2728
E K E+ C+RC DGG LVLCDK C K YHLSCL + P G W CPWH CD+CG+PS FC CP SFC +H E + P T + C H
Sbjct: 1246 EGKKQSEDECFRCGDGGQLVLCDKKGCTKAYHLSCLDRTKRPFGRWDCPWHHCDVCGKPSDAFCQHCPNSFCKAH--EEGALRPHPVTSRLCCQEH 1339
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581]) HSP 1 Score: 335.88 bits (860), Expect = 1.505e-96 Identity = 193/578 (33.39%), Postives = 303/578 (52.42%), Query Frame = 2
Query: 476 AQYSFQSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVA-GKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDC--VDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
A +SVC VCE +E+ ++ C G C +HL CL + PT K C C +G++ C C++ + ++ C CG+ YH++CL +S + + DN+ CP H C+SC + A+ K++ CLRCP+++H DLC+AAG+ L+ + ++C HF N + H + +WCF C K G L C CPA++H +C++ + + C +CR+ ++P+Y ++++VK+ YRWWP EI HPRN P NI L G +PV F GS +Y W + R + S + +G + + F + L A + Q+ + R + ++ PY +K N+ + ++ A+I P C+C D P + +C N + EC CP +C NQ FT + +T+ +G+GL T I K +F+ EY+GELI + E R+ A++ + FYM+ + D +IDAGPKGN SR+MNHSC PNC + W VNG + G+FA+ +I + ELTF+Y + + E C C + NC+GFLG
Sbjct: 725 ASVKKESVCQVCEKTSED--LVTCEGHCFATYHLQCLG---LDHPTDK--VLCTACRTGVHACFTCKQSE--GEVKRCSVLHCGKYYHEACLRLS---ALTVFDNRGFRCPLHTCLSCHYSNRGTAKATKGKMIRCLRCPVAYHAGDLCVAAGSEMLTSTAIVCTNHF-NPKKGYSHHSHVNVSWCFICSKGGRLLCCESCPAAFHPDCLNIAMPDGSWFCNDCRSGKKPKYRDIIWVKLGNYRWWPAEIRHPRNIPTNIQHLRHEIGEFPVYFFGSKDYFWTHQGRVFPYIEGDRGSRHQRNG----IGKVFKTALLEAETRFKQIKME--------REAKEAHENNKKPPPYKYIK-TNKPCGRVQIYTADISEIPK----------CNCKPTDERPCSFESECLNRMLLYECHPQVCPAGERCMNQDFTKRLYPETKTIRTAGKGWGLLTLRDIKKGEFVNEYVGELIDEEECRARIRYAQENDITHFYMLTINKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCDIPTGTELTFNYNLD-CLGNEKTVCRCGAPNCSGFLG 1265 HSP 2 Score: 107.071 bits (266), Expect = 5.013e-23 Identity = 49/96 (51.04%), Postives = 57/96 (59.38%), Query Frame = 2
Query: 2441 ESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKSICLLH 2728
E K E+ C+RC DGG LVLCDK C K YHLSCL + P G W CPWH CD+CG+PS FC CP SFC +H E + P T + C H
Sbjct: 1293 EGKKQSEDECFRCGDGGQLVLCDKKGCTKAYHLSCLDRTKRPFGRWDCPWHHCDVCGKPSDAFCQHCPNSFCKAH--EEGALRPHPVTSRLCCQEH 1386
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd1a (nuclear receptor binding SET domain protein 1a [Source:ZFIN;Acc:ZDB-GENE-080519-3]) HSP 1 Score: 332.413 bits (851), Expect = 8.940e-95 Identity = 191/573 (33.33%), Postives = 300/573 (52.36%), Query Frame = 2
Query: 491 QSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPC---KKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
++VC VCE E +L C G C FHL C+ L E + F C +C SG++ C +C+ +D+ C CG+ YH C+ N+ C H C++C T NP +L C+RCP+++H ND CMAAG+ L+ + ++CP HF + N H+ + +WCF C + G L C CPA++H EC++ + + C +CR ++P+Y ++L+VKV +YRWWP E+ P+N P NIL++ G +PV F GS +Y W + R + S+I K GT D + L A + L +R + ++ PY ++K +N+ K +++ A++ ++ C D P +C N + EC C +C+NQ FT ++ + +F+T +RG+GL++ I K F+ EY+GE+I + E R+ +A+ + +FYM+ L D +IDAGPKGN +R+MNH C PNC + W VNG + G+FAL++IG+ ELTF+Y + + C C + NC+GFLG
Sbjct: 1206 ENVCQVCEQPGE---LLLCEGHCCGAFHLQCI-GLSE---MPRGRFVCKECKSGLHTCFVCKLSG--EDVRRCMVPVCGKFYHAECILK---YAPTAPQNRGFRCSLHVCLACY---ITNPNNPSISKGRLTRCVRCPVAYHANDYCMAAGSVPLANNSILCPNHFTPRKGCKN-HEHINVSWCFVCSEGGSLLCCESCPAAFHRECLNIEMPQDSWYCNDCRAGKKPQYKDILWVKVGRYRWWPAEVTLPKNVPENILRMKHEVGEFPVHFFGSKDYVWTYQARCFPYMEGDASNIEKMGKGT---DAVYKKALNEAAE----RFRELQAEKEMRQLQEDRKNDKKPPPYKHIK-VNRPIGKVQILTADLS--------EIPRCNCKATDETPCGMDSECINRMLMYECNPQVCAAGERCQNQCFTKREYSPVEIFRTLSRGWGLRSVSEIKKGAFVSEYVGEMIDEEECRARIKHAQDNDISNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALEDIGAGVELTFNYNLE-CLGNGKTVCKCGAPNCSGFLG 1745 HSP 2 Score: 84.7297 bits (208), Expect = 4.618e-16 Identity = 36/87 (41.38%), Postives = 50/87 (57.47%), Query Frame = 2
Query: 2411 EKFIKDKDSVESKTI--HENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSH 2665
+K + K +S+ I E+ C+ C D G ++ C K CPK YH CL L + P+G W CPWH C+ CG+ + FC CP S+C H
Sbjct: 1762 KKRVSGKRKSQSEVIKEREDECFYCGDSGQIISCKKPGCPKVYHADCLNLNKRPAGRWECPWHQCNECGREAASFCEMCPNSYCKQH 1848
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd1b (nuclear receptor binding SET domain protein 1b [Source:ZFIN;Acc:ZDB-GENE-080519-2]) HSP 1 Score: 290.426 bits (742), Expect = 4.497e-86 Identity = 159/444 (35.81%), Postives = 243/444 (54.73%), Query Frame = 2
Query: 869 KLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
+L C+RCP+++H D C+ AG+ L+ + ++CP HF + N H+ + +WCF C + G L C CPA++H EC++ E + C +CR ++P Y EV++VKV +YRWWP E+ +P+N P NIL++ G +PVLF GSN+Y W + R + +S K G +D + L A K Q L LR + ++ PY ++K N+ K ++I A++ P C D P +C N + EC CP KC+NQ+F ++ + +F+T +RG+GL+ I K DF+ EY+GE+I + E R+ A++ + +FYM+ L D +IDAGPKGN +R+MNHSC PNC + W VNG + G+FAL +I + ELTF+Y + + C C + NC+GFLG
Sbjct: 14 RLTRCVRCPIAYHATDYCIPAGSVILANNLILCPNHFIPRKGCRN-HEHVNVSWCFVCSEGGSLLCCESCPAAFHRECLNIDMPEGSWFCNDCRAGKKPHYKEVVWVKVGRYRWWPAEVSNPKNIPENILRMRHDVGEFPVLFFGSNDYLWTYQARVFPYMEGDANSKEKMGKG---VDSVYKKALEEAAKRFQE----LQAEKELRQLQEDRRNDKKPPPYKHIK-ANRPIGKVQIITADLSEIPR--------CNCRATDESPCGMDSECINRMLLYECNPQVCPAGEKCQNQRFLKREYSEVEIFRTLSRGWGLRGCHDIKKGDFVNEYVGEVIDEEECRARIRQAQENDIGNFYMLTLDKDRIIDAGPKGNEARFMNHSCQPNCETQKWTVNGDTRVGLFALVDISTGTELTFNYNLE-CLGNGKTVCKCGAPNCSGFLG 439 HSP 2 Score: 93.5893 bits (231), Expect = 3.744e-19 Identity = 42/99 (42.42%), Postives = 57/99 (57.58%), Query Frame = 2
Query: 2417 FIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKS 2713
++K K E E+ C+ C DGG +V C + CPK YH CL L + P+G W CPWH CD+CGQ S FC CP+S+C H ++ + I + R S
Sbjct: 459 YMKRKQQQEVTKEREDECFSCGDGGQMVSCKRPGCPKVYHADCLNLTKRPAGRWECPWHQCDLCGQESASFCEMCPSSYCVEH-RDGMLFISKLDGRLS 556
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:ZFIN;Acc:ZDB-GENE-050324-2]) HSP 1 Score: 253.062 bits (645), Expect = 5.786e-69 Identity = 175/513 (34.11%), Postives = 244/513 (47.56%), Query Frame = 2
Query: 692 DDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVD----NCPKQD---------CKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
D LL+CE DC RL+H CL + E C C + P +L L D +++ ++ SH + + +L+KL A K G L C CPAS+H C++ E ++C CR ++P Y ++++VK+ YRWWP EI +PR P NI L G +PV F GS++Y W+ + R F + F E G +++ F L A K Q + A T E L N +++ +KLIKAN V KVQ + D + NC D C N + + EC CP +C NQ F+ + + V KTS RG+GLKT + K DFI+EY+GELI E R+ +A K + +FYM+ LT D VIDAGPKGNLSR+MNHSC PNC + W VNG + G+F L +I +D ELTF+Y + + C C + NC+GFLG
Sbjct: 662 DSLLSCEG-DCNRLFHPECLTSAGGTEGET-----------ICTECRTGKPGPSPIPSYRL-------LVHDHTDTVLSSYTFK---SHYLLTESNRAELMKLPMIPSSSSATKKNVGKGGRLLCCEACPASFHPSCLNIEMPEGVWLCSECRAGKKPHYKQIVWVKLGNYRWWPAEICNPRLVPSNIQSLKHDVGDFPVFFFGSHDYYWIHQGRV--FPYVESDKNFAE--GQVGINKTFKKALEEAAKRFQ-------------ELKAQRETKEALEQERN----SRRPPPYKLIKANKPVG------KVQVHVADLSEVPRCNCRPTDERPCGQDSQCLNRMLQYECHPQVCPAAERCLNQSFSKRVYPDTEVIKTSGRGWGLKTKQDLKKGDFIMEYVGELIDLEECRQRISHANKNHITNFYMLTLTKDRVIDAGPKGNLSRFMNHSCSPNCETQKWTVNGDIRIGLFTLCDIAADTELTFNYNLD-CLGNGRTSCHCGAENCSGFLG 1124 HSP 2 Score: 95.9005 bits (237), Expect = 1.291e-19 Identity = 38/75 (50.67%), Postives = 49/75 (65.33%), Query Frame = 2
Query: 2441 ESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSH 2665
ES+ HE +C+ C +GG LV+CD+ +CPK YHL CL L + P G W CPWH C +C +P+ C CP SFC H
Sbjct: 1154 ESRQTHEYYCFCCGEGGELVMCDRKDCPKAYHLLCLNLTKPPYGRWECPWHQCSVCQRPASASCQFCPESFCREH 1228
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581]) HSP 1 Score: 299.286 bits (765), Expect = 3.777e-85 Identity = 186/623 (29.86%), Postives = 292/623 (46.87%), Query Frame = 2
Query: 494 SVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFK---------TGVKLH------------------------------------------CNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTA-QFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDC--VDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
++C CE T +++ C G C FH+ CL + P K C +C +G++ C C+ ++ C S CGR YH+ C++ S+ + + + CP H C+SC ++ ++ C+RCP+++H +D C+AAG+ LS ++C HF H + WCF C + G+ L C CPA++H EC+ E + C CR ++P+Y ++++VK+ YRWWP EI PRN P NI L G +PV F GS++Y W + R + + S+ +K T +++ F L A +Q L R + + + Y ++K N+ + ++ A++ P C+C D P +C N + + EC + CP +C+NQ FT + + KT+ RG+GL T + I K +F+ EY+GELI + E R+ A + N +FYM+ + D +IDAGPKGN SR+MNHSC PNC + W VNG + G+FA +I + ELTF+Y + + E C C + NC+GFLG
Sbjct: 567 ALCLACE-KTGGGSLVSCEGQCCGTFHVECLG--VQTAPGDK--VMCNECSTGLHVCFACKCAGA--EVRRCAVSSCGRFYHEECVQRSS---AAVFEGRRFRCPLHVCLSCHLAYPASSRASRGRMQRCVRCPVAYHTSDSCLAAGSKVLSPYSIVCSGHFTPNKRDSTWH--VNVNWCFLCSRGVIGAPLPDAGLALFEQSSHYLLSEYKRSSELGKLPMIPVVPAAAAKACGKGGCLLCCESCPAAFHPECLGMEPPEGTWCCAECRAGKKPQYHDIVWVKLGNYRWWPAEICQPRNIPQNIQNLKHTVGQFPVQFFGSHDYYWTTQGRVFPYMEGDKGSTDYK----TNCLNKTFKRALLEAAARYQA----LKAQRETREAQETERSERKPPTYKHIKS-NKPVGRVQVYTADVSEIPR----------CNCKPTDESPCGLDSECLNRMLQYECHPSICPAGDRCQNQAFTKRAYPPSQIVKTAGRGWGLLTLVSIRKGEFVNEYVGELIDEEECRKRIKYAHEKNLSNFYMLTIEKDRIIDAGPKGNFSRFMNHSCQPNCETQKWTVNGDTRVGLFATSDIATGTELTFNYNLD-CLGNEKTICKCGAPNCSGFLG 1157 HSP 2 Score: 106.686 bits (265), Expect = 1.530e-23 Identity = 44/74 (59.46%), Postives = 51/74 (68.92%), Query Frame = 2
Query: 2444 SKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSH 2665
++ HE+ CYRC DGG LV+CDK CPK YHLSCL L + P G W CPWH CD+CG+PS C CP SFC H
Sbjct: 1189 ARAEHEDECYRCGDGGELVMCDKKACPKAYHLSCLNLTKPPFGKWECPWHHCDVCGRPSVRSCELCPNSFCKEH 1262
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005461.1 (pep scaffold:Pmarinus_7.0:GL477205:1717:42601:-1 gene:ENSPMAG00000004962.1 transcript:ENSPMAT00000005461.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 120.553 bits (301), Expect = 7.376e-28 Identity = 71/202 (35.15%), Postives = 105/202 (51.98%), Query Frame = 2
Query: 1628 QPSICDCV------DNCPKQDCKNYLNKIECQITQCP---KCKNQQFTNVDHK-NIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKN-----ESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENW--IVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
+P C C D+ + C N L EC + CP C N++F + + F+T++RG+G++TT ND IIEYLGE++++ RML A++ Y + L +VID+ GN +R++NHSC PNC ++ W VNG + G+FALK+I ELT+DY + CLC S NC +G
Sbjct: 1113 EPVSCSCKRPEETEDSACTEGCLNRLVYAECVQSSCPCGELCTNRRFQRQERSAGLERFRTTDRGWGVRTTHHFQANDLIIEYLGEVLSEANFRAFAPRSRML-AQRGEQAGMYCVQLDSGVVIDSYRMGNEARFINHSCQPNCEMQKWCVSVNGIYRIGLFALKDIPISTELTYDYNFHTFTAESQRPCLCGSPNCRNVIG 1313
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003690.1 (pep scaffold:Pmarinus_7.0:GL484755:705:3732:1 gene:ENSPMAG00000003373.1 transcript:ENSPMAT00000003690.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 93.9745 bits (232), Expect = 1.651e-21 Identity = 41/80 (51.25%), Postives = 54/80 (67.50%), Query Frame = 2
Query: 1943 DLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
D +IDAGPKGN SR+MNHSC PNC + W VNG + G+FA+ +I ELTF+Y + + E C+C + NC+GFLG
Sbjct: 2 DRIIDAGPKGNFSRFMNHSCQPNCETQKWTVNGDTRVGLFAVSDIPCGTELTFNYNLD-CLGNEKTVCMCGAPNCSGFLG 80 HSP 2 Score: 71.633 bits (174), Expect = 5.542e-14 Identity = 35/79 (44.30%), Postives = 45/79 (56.96%), Query Frame = 2
Query: 2453 IHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHF-------CDICGQPSKLFCVRCPASFCDSHA 2668
+H++ CYRC DGG LV+CD NC KT+HL+CL L P G W P C G+ + FC CP+SFC H+
Sbjct: 111 VHDSECYRCKDGGELVMCDHRNCTKTFHLACLNLGTLPEGKWA-PRTLPLPHATRCRRSGKTAVAFCQICPSSFCKQHS 188
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004922.1 (pep scaffold:Pmarinus_7.0:GL479351:23010:32607:-1 gene:ENSPMAG00000004401.1 transcript:ENSPMAT00000004922.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 98.5969 bits (244), Expect = 3.299e-21 Identity = 59/172 (34.30%), Postives = 87/172 (50.58%), Query Frame = 2
Query: 1640 CDCVDNCPKQDCKNYLNKIECQITQCPKCKNQQF---TNVDHKNIAVFKTSNR----------GFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRIS 2116
C C C + C YL EC C C NV KN + + + G+G+ +P+ KN+FI EY GE+I+++E++ R K+ ++ +L D V+DA KGN R+ NHS PNCY + +VNG + G+FA + I + +EL FDYR S
Sbjct: 597 CRCKAQCNTKQCPCYLAVRECDPDLCQTCGAADHWDNRNVSCKNCCIQRGLKKHLLLAPSDVAGWGIFIKVPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCS--FLFNLNNDFVVDATRKGNKIRFANHSVSPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYS 766
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: SUV39H2 (suppressor of variegation 3-9 homolog 2 [Source:HGNC Symbol;Acc:HGNC:17287]) HSP 1 Score: 88.5817 bits (218), Expect = 9.600e-19 Identity = 55/149 (36.91%), Postives = 85/149 (57.05%), Query Frame = 2
Query: 1697 EC-QITQC-PKCKNQQFTNVDHKNIAVFKTSN-RGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHL---TGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGY----PKKGVFALKEIGSDQELTFDYRI 2113
EC + QC P+CKN+ + +F+T N RG+G+KT I KN F++EY+GELI E+E R + + A Y+ L D +DA GN+S ++NHSC+PN + + +N + P+ FA+ ++ + +ELTFDY I
Sbjct: 231 ECNSLCQCGPECKNRVVQKGIPFPLCIFRTDNGRGWGVKTMQKIKKNSFVMEYVGELIPSEEAERRGVIYDR--AGTTYLFDLDFCKDDYTVDATFYGNISHFVNHSCEPNLQVYSTFINNHDFSQPRIAFFAMDDLAAGEELTFDYNI 377
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Yeast
Match: SET2 (Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain(CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000003704]) HSP 1 Score: 127.487 bits (319), Expect = 1.550e-30 Identity = 67/175 (38.29%), Postives = 97/175 (55.43%), Query Frame = 2
Query: 1670 DCKNYLNKIECQITQCPKC----KNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
DC N L IEC C C +NQ+F + IA+FKT ++G+G++ I N FI EY GE+I + E R+++ + + K FY + L IDA KG+L+R+ NHSC PN Y+ W+V + G+FA ++I +E+TFDY + + C C NC GFLG
Sbjct: 87 DCINRLTLIECVNDLCSSCGNDCQNQRFQKKQYAPIAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYDQRHFKHFYFMMLQNGEFIDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYGAQAQK-CYCEEPNCIGFLG 260
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Yeast
Match: SET1 (Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain [Source:SGD;Acc:S000001161]) HSP 1 Score: 90.1225 bits (222), Expect = 1.010e-18 Identity = 49/146 (33.56%), Postives = 78/146 (53.42%), Query Frame = 2
Query: 1745 NVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAF-CLCSSNNCTGFL 2179
N K + +++ +GL I + IIEY+GE I + +E+R K Y+ + + VIDA KG ++R++NH CDPNC + V G + ++AL++I + +ELT+DY+ E+ CLC + NC GFL
Sbjct: 934 NKRKKPVMFARSAIHNWGLYALDSIAAKEMIIEYVGERIRQPVAEMREKRYLKNGIGSSYLFRVDENTVIDATKKGGIARFINHCCDPNCTAKIIKVGGRRRIVIYALRDIAASEELTYDYKFEREKDDEERLPCLCGAPNCKGFL 1079
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Match: EDO43156 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZJ4]) HSP 1 Score: 352.829 bits (904), Expect = 1.338e-108 Identity = 225/721 (31.21%), Postives = 349/721 (48.40%), Query Frame = 2
Query: 551 GICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVS-DYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKAN-------IIVPPAKLPPKVQPSICDCV-DNCPKQD--CKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQ 2671
G C +H C+ K F+C +C SG++ C +C++ D+ AC C + YHK CL+ I D + CP H+C +C+ + +L +C+RCP ++H C+ AG ++ ++C +HF K + H + WCF C G + C CPA++H EC+S + E R+ C +C + YG++++VK+ YRWWP I +PR+ P NI + G +PV+FLGS+++ W+ K R + + ESG + + F L A + + + A E +++ +K ++K IK N II+ P+++P +C+C D QD C N + + EC ++CP KC+NQ+F + + F+ +RG+GL++ I K F+IEY+GELI +++ R K + ++YM+ + D +IDAGP GNLSR+MNHSC PNC + W VNG + G+F +++ S +ELTFDY CL +C G N K S+N S L G+ K ++ +NE D NA ++ + K +HE+ C+ C DGG L++CD+ C K YH+ CL L++ P G W CPWHFCD CG+ + + C CP SFC SHAQ
Sbjct: 4 GDCNSAYHPDCIGL----STAPKGKFKCDECTSGVHSCFVCRQTG---DVKACSQPLCSKFYHKECLQSYKCSKI---DGDRIYCPLHFCSTCISNKTPVNRG---RLTKCIRCPTAYHAG--CLVAGCMPITSHLMVCAKHFLPNKSKAH-HTHVNVNWCFVCSIGGTLICCESCPAAFHPECISYEGIPEGRFYCKDCVEGKSLLYGDIVWVKLGMYRWWPAMICNPRDVPTNIQSMRHQPGEFPVMFLGSHDFYWIHKGRVFSYQDGDKGT---ESGNNKYLAKVFKKALVEAKEKYDEW-----------------KKAREDKAEQDLQRFCKKPPQYKHIKTNKCTTAQRIILDPSEMP------VCECTPDQACGQDANCLNLMLQFECVASRCPAGDKCQNQRFQKRQYVDCEPFRAHSRGWGLRSKQAIKKGTFVIEYVGELI--DDATCRERVKKGDDDTNYYMLTIDKDCIIDAGPMGNLSRFMNHSCYPNCETQKWTVNGEVRVGLFTSRDVESQEELTFDY------------CL----DCHG---------NEKKKCHCGSQNCSGFL--GVRPK------------------------TQNAQMNE------DKAKNAALKRRKRKPKKPAVKQVHEDDCFICGDGGQLIMCDRSGCLKCYHVDCLNLDKKPQGRWQCPWHFCDNCGKRATVLCSECPNSFCRSHAQ 623
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Match: EDO43763 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXE9]) HSP 1 Score: 129.798 bits (325), Expect = 1.095e-32 Identity = 69/183 (37.70%), Postives = 104/183 (56.83%), Query Frame = 2
Query: 1667 QDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRIS--GVIMKEDAFCLCSSNNCTGFLGPIKSLP 2200
+DC N L IEC +CP C N++F + VFKT +G+G+KT + +N F+IEY GE++ + + R + + +Y + L D +IDA KG++SR++NHSC+PNC + W VNG + G F L+ I + +ELTFDY++ G I + C C S +C G +G K P
Sbjct: 45 EDCLNRLLMIECN-HRCPCGDLCTNRRFQEGCKIKVEVFKTEKKGWGVKTLEDLEQNQFVIEYCGEVMNYRDFQSRAQRYDRQKRRHYYFMTLRADEIIDATLKGSISRFINHSCEPNCVTQKWTVNGLLRIGFFTLRTIKAGEELTFDYQLQRYGKIAQT---CYCESPSCRGIIGGEKHTP 223
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Match: EDO30322 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T142]) HSP 1 Score: 96.2857 bits (238), Expect = 2.115e-20 Identity = 56/173 (32.37%), Postives = 86/173 (49.71%), Query Frame = 2
Query: 1640 CDCVDNCPKQDCKNYLNKIECQITQC------------PKCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGV 2122
C C C + C +L EC C CKN K++ + + G+G+ + KN+FI EY GE+I+++E++ R K+ ++ +L D V+DA KGN R+ NHS PNCY + +VNG + G+FA ++I + +EL FDYR S
Sbjct: 501 CRCKAQCNTKQCPCFLAVRECDPDLCGTCGADNFDQDSKTCKNVSLQRGQRKHMLLAPSDVAGWGIYIKQSVKKNEFISEYCGEVISQDEADRRGKVYDKYMCS--FLFNLNNDFVVDATRKGNKIRFANHSISPNCYAKVMMVNGDHRIGIFAKRDIEAGEELFFDYRYSAT 671
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Match: EDO44546 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVC2]) HSP 1 Score: 88.1965 bits (217), Expect = 1.309e-19 Identity = 48/145 (33.10%), Postives = 76/145 (52.41%), Query Frame = 2
Query: 1745 NVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFL 2179
V K + K+S +GL PI ++ +IEY+GE+I + ++ R ++ YM L +IDA GN +R++NH CDPNCY + V K +++ ++I D+E+T+DY+ I E CLC + C G L
Sbjct: 70 RVRKKQLKFAKSSIHDWGLFALEPIAADEMVIEYVGEVIRQAIADYRERCYEERGIGSSYMFRLDETTIIDATTMGNFARFINHCCDPNCYAKVIAVENMKKIVIYSKRDIQVDEEITYDYKFP--IEDEKIPCLCGAPQCRGTL 212
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Match: EDO30857 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZK5]) HSP 1 Score: 88.1965 bits (217), Expect = 5.688e-19 Identity = 52/147 (35.37%), Postives = 75/147 (51.02%), Query Frame = 2
Query: 1745 NVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDF--YMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFL 2179
N + IAVF++ G GL T I + +IEY G LI ++ R + +K YM + G V+DA GN +R++NHSC+PNCY ++G K +FA K I +ELT+DY+ + E C C S C +L
Sbjct: 146 NYNKGTIAVFRSGIHGRGLYCTRHIAAGEMVIEYSGMLIRSTLTDKR---EAYYESKGIGCYMFRIDGTYVVDATTSGNAARFINHSCEPNCYSRVVTIDGNKKILIFASKSISRGEELTYDYKFP--LEDEKLPCHCKSKRCRKYL 287
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:NCBI gene;Acc:101172132]) HSP 1 Score: 339.347 bits (869), Expect = 2.140e-98 Identity = 211/665 (31.73%), Postives = 333/665 (50.08%), Query Frame = 2
Query: 227 EGKARCEWSNLRLNEKKS---FIKSFKIDENDHRKSIKSRKPQRSPSPNLKKYRKDSLHNENSVIKIEKESVPIFQMEIQRLVASPAQYSFQSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPN--FQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDC--VDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
E + R + S RL E +S + K ++ K+ K++K + SP P+ + + E+ P ++ + ++ VC VCE E+ ++ C G C FHLHCL P+ KP C C +GI+ C C++ + ++ C CG+ YH++C+ ++ + DNK L CP H C+SC T ++ +L+ CLRCP+++H DLC+AAG+ ++ + ++C HF N + H + +WCF C K G L C CPA++H +C++ + + C +CR ++PRY ++++VK+ YRWWP EI HPRN P NI L G +PV F GS +Y W + R + S + +G + R F + L A + + M R + ++ + PY +K +N+ + ++ A++ P C+C D P + +C N + + EC CP +C NQ FT + + KT +G+GL I K F+ EY+GELI + E R+ A + N +FYM+ + D +IDAGPKGN SR+MNHSC PNC + W VNG + G+FA+ I + ELTF+Y + + E C C + NC+GFLG
Sbjct: 499 EARKRADKSQPRLQEDQSTEKPKRRRKRKQDGEMKTSKAKKRRSSPCPDAEGSGSE-----------ERPDSPSDSLDGTKKGEKRKEF----VCQVCEQAGED--LVPCEGQCCGMFHLHCLG------PSFKPEDKLLCQQCRAGIHSCFACKQSE--GEVRRCHVVHCGKFYHEACIRLNPLT---VFDNKGLRCPLHACLSCHYGSRTKHKSTKGRLMRCLRCPVAYHVGDLCVAAGSEMITNTAIVCTNHF-NAKKGYSHHSHVNVSWCFVCSKGGQLLCCESCPAAFHPDCLNIAMPDGSWYCNDCRAGKKPRYRDIIWVKLGTYRWWPAEIQHPRNIPTNIQHLRHEIGEFPVFFFGSRDYFWTHQGRVFPYMEGDRGSKHQRTG----IGRVFKNALLEA----EARFKEMKMK---REAKEAQESSRKPPPYKFIK-VNRPYGRVQVYTADVSEIPK----------CNCKPTDERPCGFESECLNRMLQYECHPQVCPSGERCCNQDFTKRLYPETKIIKTPGKGWGLVALRDIKKGKFVNEYIGELIDEEECRARIKYAHENNITNFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCHIPAGTELTFNYNLD-CLGNEKTICRCGAPNCSGFLG 1111 HSP 2 Score: 103.99 bits (258), Expect = 4.483e-22 Identity = 52/112 (46.43%), Postives = 62/112 (55.36%), Query Frame = 2
Query: 2441 ESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKSICLLHKSPPENQTSYLHDEAS 2776
E K E+ C+RC DGG LVLCDK C K YHLSCL L + P G W CPWH CD+CG+ S+ FC CP SFC +H + + P + CL H E HD S
Sbjct: 1139 EGKKKSEDECFRCGDGGQLVLCDKKTCTKAYHLSCLNLTKRPFGRWDCPWHHCDVCGKNSEAFCQLCPNSFCKAH--QEGGLWPRPPGGELCCLEHDE-LEGANGPAHDPGS 1247
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd1b (histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [Source:NCBI gene;Acc:101161079]) HSP 1 Score: 333.954 bits (855), Expect = 3.112e-95 Identity = 191/570 (33.51%), Postives = 298/570 (52.28%), Query Frame = 2
Query: 491 QSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
+++C VCE E +L C G C FHL C+ +L + K F C +C SG++ C +C+K + +D+ C CG+ YH C+ +N N+ C H C++C + + +LV C+RCP+++H DLCMAAG+ LS + ++CP HF + N H+ + +WCF C + G L C CPA++H EC++ + + C +C+ ++P Y ++L+VKV +YRWWP E+ HP+ P NI ++ G +PV F GSN+Y W + R + +S K G +D + L A V L LR + + PY ++K +N+ K ++ A++ +V C D P +C N + EC CP KC NQ FT + + +F+T +RG+GL+ I K F+ EY+GE+I + E R+ +A++ + +FYM+ L D +IDAGPKGN +R+MNH C PNC + W VNG + G+FAL ++ + ELTF+Y + + C C + NC+GFLG
Sbjct: 1282 ETICQVCEKTGE---LLLCEGQCCGAFHLACI-SLAD---APKGKFVCPECKSGVHTCFVCKK--RGEDVRRCMIPVCGKFYHGECI--TNHAPT-APVNRGFRCSIHVCLTCFIANPNSSSISKGRLVRCVRCPVAYHATDLCMAAGSVVLSSNSIVCPNHFTPRRGVKN-HEHVNVSWCFVCTEGGSLLCCESCPAAFHRECLNIEMPKGSWYCNDCKAGKKPHYKDILWVKVGRYRWWPAEVSHPKTIPENIQRMRHDVGEFPVHFFGSNDYLWTYQARVFPYMDVDANSKEKMGKG---VDTTYKKALEEAA----VRFRELQAEKELRQLQEDRKNDRKPPPYKHIK-VNRPIGKVQIFTADLS--------EVPRCNCKATDESPCGSDSECINRMLLYECNPQVCPAGEKCLNQAFTKRQYSQVEIFRTLSRGWGLRCVHDIKKGQFVSEYVGEVIDEEECRSRIRHAQENDICNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALVDVKAGTELTFNYNLE-CLGNGKTVCKCGAPNCSGFLG 1821 HSP 2 Score: 92.0485 bits (227), Expect = 2.510e-18 Identity = 35/70 (50.00%), Postives = 45/70 (64.29%), Query Frame = 2
Query: 2456 HENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSH 2665
E+ C+ C DGG +V C K CPK YH CL L + P+G W CPWH CD+CG+ + FC CP+S+C H
Sbjct: 1855 REDECFSCGDGGQMVSCKKPGCPKVYHADCLNLTKRPAGRWECPWHQCDVCGKEAASFCEMCPSSYCCQH 1924
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd1b (histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [Source:NCBI gene;Acc:101161079]) HSP 1 Score: 333.954 bits (855), Expect = 3.255e-95 Identity = 191/570 (33.51%), Postives = 297/570 (52.11%), Query Frame = 2
Query: 491 QSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
+++C VCE E +L C G C FHL C+ + P K F C +C SG++ C +C+K + +D+ C CG+ YH C+ +N N+ C H C++C + + +LV C+RCP+++H DLCMAAG+ LS + ++CP HF + N H+ + +WCF C + G L C CPA++H EC++ + + C +C+ ++P Y ++L+VKV +YRWWP E+ HP+ P NI ++ G +PV F GSN+Y W + R + +S K G +D + L A V L LR + + PY ++K +N+ K ++ A++ +V C D P +C N + EC CP KC NQ FT + + +F+T +RG+GL+ I K F+ EY+GE+I + E R+ +A++ + +FYM+ L D +IDAGPKGN +R+MNH C PNC + W VNG + G+FAL ++ + ELTF+Y + + C C + NC+GFLG
Sbjct: 1605 ETICQVCEKTGE---LLLCEGQCCGAFHLACISLA--DAPKGK--FVCPECKSGVHTCFVCKK--RGEDVRRCMIPVCGKFYHGECI--TNHAPT-APVNRGFRCSIHVCLTCFIANPNSSSISKGRLVRCVRCPVAYHATDLCMAAGSVVLSSNSIVCPNHFTPRRGVKN-HEHVNVSWCFVCTEGGSLLCCESCPAAFHRECLNIEMPKGSWYCNDCKAGKKPHYKDILWVKVGRYRWWPAEVSHPKTIPENIQRMRHDVGEFPVHFFGSNDYLWTYQARVFPYMDVDANSKEKMGKG---VDTTYKKALEEAA----VRFRELQAEKELRQLQEDRKNDRKPPPYKHIK-VNRPIGKVQIFTADLS--------EVPRCNCKATDESPCGSDSECINRMLLYECNPQVCPAGEKCLNQAFTKRQYSQVEIFRTLSRGWGLRCVHDIKKGQFVSEYVGEVIDEEECRSRIRHAQENDICNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALVDVKAGTELTFNYNLE-CLGNGKTVCKCGAPNCSGFLG 2144 HSP 2 Score: 92.4337 bits (228), Expect = 2.258e-18 Identity = 35/70 (50.00%), Postives = 45/70 (64.29%), Query Frame = 2
Query: 2456 HENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSH 2665
E+ C+ C DGG +V C K CPK YH CL L + P+G W CPWH CD+CG+ + FC CP+S+C H
Sbjct: 2178 REDECFSCGDGGQMVSCKKPGCPKVYHADCLNLTKRPAGRWECPWHQCDVCGKEAASFCEMCPSSYCCQH 2247
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd1b (histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [Source:NCBI gene;Acc:101161079]) HSP 1 Score: 333.954 bits (855), Expect = 3.994e-95 Identity = 191/570 (33.51%), Postives = 298/570 (52.28%), Query Frame = 2
Query: 491 QSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
+++C VCE E +L C G C FHL C+ +L + K F C +C SG++ C +C+K + +D+ C CG+ YH C+ +N N+ C H C++C + + +LV C+RCP+++H DLCMAAG+ LS + ++CP HF + N H+ + +WCF C + G L C CPA++H EC++ + + C +C+ ++P Y ++L+VKV +YRWWP E+ HP+ P NI ++ G +PV F GSN+Y W + R + +S K G +D + L A V L LR + + PY ++K +N+ K ++ A++ +V C D P +C N + EC CP KC NQ FT + + +F+T +RG+GL+ I K F+ EY+GE+I + E R+ +A++ + +FYM+ L D +IDAGPKGN +R+MNH C PNC + W VNG + G+FAL ++ + ELTF+Y + + C C + NC+GFLG
Sbjct: 1688 ETICQVCEKTGE---LLLCEGQCCGAFHLACI-SLAD---APKGKFVCPECKSGVHTCFVCKK--RGEDVRRCMIPVCGKFYHGECI--TNHAPT-APVNRGFRCSIHVCLTCFIANPNSSSISKGRLVRCVRCPVAYHATDLCMAAGSVVLSSNSIVCPNHFTPRRGVKN-HEHVNVSWCFVCTEGGSLLCCESCPAAFHRECLNIEMPKGSWYCNDCKAGKKPHYKDILWVKVGRYRWWPAEVSHPKTIPENIQRMRHDVGEFPVHFFGSNDYLWTYQARVFPYMDVDANSKEKMGKG---VDTTYKKALEEAA----VRFRELQAEKELRQLQEDRKNDRKPPPYKHIK-VNRPIGKVQIFTADLS--------EVPRCNCKATDESPCGSDSECINRMLLYECNPQVCPAGEKCLNQAFTKRQYSQVEIFRTLSRGWGLRCVHDIKKGQFVSEYVGEVIDEEECRSRIRHAQENDICNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALVDVKAGTELTFNYNLE-CLGNGKTVCKCGAPNCSGFLG 2227 HSP 2 Score: 92.0485 bits (227), Expect = 2.371e-18 Identity = 35/70 (50.00%), Postives = 45/70 (64.29%), Query Frame = 2
Query: 2456 HENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSH 2665
E+ C+ C DGG +V C K CPK YH CL L + P+G W CPWH CD+CG+ + FC CP+S+C H
Sbjct: 2261 REDECFSCGDGGQMVSCKKPGCPKVYHADCLNLTKRPAGRWECPWHQCDVCGKEAASFCEMCPSSYCCQH 2330
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd1b (histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [Source:NCBI gene;Acc:101161079]) HSP 1 Score: 333.954 bits (855), Expect = 3.994e-95 Identity = 191/570 (33.51%), Postives = 298/570 (52.28%), Query Frame = 2
Query: 491 QSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVDNCP---KQDCKNYLNKIECQITQCP---KCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG 2182
+++C VCE E +L C G C FHL C+ +L + K F C +C SG++ C +C+K + +D+ C CG+ YH C+ +N N+ C H C++C + + +LV C+RCP+++H DLCMAAG+ LS + ++CP HF + N H+ + +WCF C + G L C CPA++H EC++ + + C +C+ ++P Y ++L+VKV +YRWWP E+ HP+ P NI ++ G +PV F GSN+Y W + R + +S K G +D + L A V L LR + + PY ++K +N+ K ++ A++ +V C D P +C N + EC CP KC NQ FT + + +F+T +RG+GL+ I K F+ EY+GE+I + E R+ +A++ + +FYM+ L D +IDAGPKGN +R+MNH C PNC + W VNG + G+FAL ++ + ELTF+Y + + C C + NC+GFLG
Sbjct: 1688 ETICQVCEKTGE---LLLCEGQCCGAFHLACI-SLAD---APKGKFVCPECKSGVHTCFVCKK--RGEDVRRCMIPVCGKFYHGECI--TNHAPT-APVNRGFRCSIHVCLTCFIANPNSSSISKGRLVRCVRCPVAYHATDLCMAAGSVVLSSNSIVCPNHFTPRRGVKN-HEHVNVSWCFVCTEGGSLLCCESCPAAFHRECLNIEMPKGSWYCNDCKAGKKPHYKDILWVKVGRYRWWPAEVSHPKTIPENIQRMRHDVGEFPVHFFGSNDYLWTYQARVFPYMDVDANSKEKMGKG---VDTTYKKALEEAA----VRFRELQAEKELRQLQEDRKNDRKPPPYKHIK-VNRPIGKVQIFTADLS--------EVPRCNCKATDESPCGSDSECINRMLLYECNPQVCPAGEKCLNQAFTKRQYSQVEIFRTLSRGWGLRCVHDIKKGQFVSEYVGEVIDEEECRSRIRHAQENDICNFYMLTLDKDRIIDAGPKGNEARFMNHCCQPNCETQKWTVNGDTRVGLFALVDVKAGTELTFNYNLE-CLGNGKTVCKCGAPNCSGFLG 2227 HSP 2 Score: 92.0485 bits (227), Expect = 2.371e-18 Identity = 35/70 (50.00%), Postives = 45/70 (64.29%), Query Frame = 2
Query: 2456 HENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSH 2665
E+ C+ C DGG +V C K CPK YH CL L + P+G W CPWH CD+CG+ + FC CP+S+C H
Sbjct: 2261 REDECFSCGDGGQMVSCKKPGCPKVYHADCLNLTKRPAGRWECPWHQCDVCGKEAASFCEMCPSSYCCQH 2330
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000081033.1 (SMESG000081033.1) HSP 1 Score: 1830.07 bits (4739), Expect = 0.000e+0 Identity = 884/889 (99.44%), Postives = 886/889 (99.66%), Query Frame = 2
Query: 113 YLSFDDDNSLDSIEDETGFQYFLYDLKVKNDAGKSLEVEGKARCEWSNLRLNEKKSFIKSFKIDENDHRKSIKSRKPQRSPSPNLKKYRKDSLHNENSVIKIEKESVPIFQMEIQRLVASPAQYSFQSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSICDCVDNCPKQDCKNYLNKIECQITQCPKCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKSICLLHKSPPENQTSYLHDEASH 2779
YLSFDDDNSLDSIEDETGFQYFLYDLKVKND GKSLEVEGKARCEWSNLRLNEKKSFIKSFKIDENDHRKSIKSRKPQRSPSPNLKK RKDSLHNENSVIKIEKESVPIFQMEIQRLVASPAQYSFQSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQ SICDCVDNCPKQDCKNYLNKIECQITQCPKCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLI+EAPIL+ESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKSICLLHKSPPENQTSYLHDEASH
Sbjct: 17 YLSFDDDNSLDSIEDETGFQYFLYDLKVKNDDGKSLEVEGKARCEWSNLRLNEKKSFIKSFKIDENDHRKSIKSRKPQRSPSPNLKKNRKDSLHNENSVIKIEKESVPIFQMEIQRLVASPAQYSFQSVCAVCEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQKVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQASICDCVDNCPKQDCKNYLNKIECQITQCPKCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLITEAPILDESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHAQETNIIIPTIKTRKSICLLHKSPPENQTSYLHDEASH 905
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000039925.1 (SMESG000039925.1) HSP 1 Score: 403.29 bits (1035), Expect = 7.943e-123 Identity = 268/838 (31.98%), Postives = 398/838 (47.49%), Query Frame = 2
Query: 527 NNAVLQCTGICKRYFHLHCLK----NLKENQPTSK--PNFQCLDCFSGIYHCILCQKV---DKIDDLLACENSDCGRLYHKSCLEMSNFIG-IEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHF-----------------ENKLVKLNA---------------------------HKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFN-----TAQFSSIFKESG-----------GTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANI------IVPPAKLP--PKVQPSICD-CVDNC-PKQDCKNYLNKIECQITQC---PKCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG--PIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSH-------AQETNIIIPTIKTRKSICLLHKSPPENQTSYLH 2764
NN V CTG C + FH CL+ L +PT+K +C+DC + C +CQK+ DK D+++ C S+CGR YH +CL ++ I + + L+CPSH C +C +D A C V CL CP SFH D C+ AG+ E++ +++ICP+H +N VKLN+ K + WCF C G + C CPAS H C + ++C +C++ R PRYG++ ++K+ YRWWP +IIHP NAP +LK + DG + V F G+N+Y W+ KT + F T + I S G T++DRD+ L++A K + LR+ S+ +N+K K +++ IK N+ I PA L P+ + D C D C P +C N EC C C+NQ+F ++ VF T NRG+ L+T PI K F+ EY+GELI + E+ R+ A + N +FYM+ L G +IDAGP N+SR+MNHSC PN Y + W VNG + G+FAL I + +ELTF+Y + K+ C C ++NC+GFLG P + P+ S+ + ++S + L N +D K ++K+ +N +DL N ++K + + CYRC + C +CP+ YHL C+ L P W CPWH CD CG+ S+ FC C S+C H + N++ + + L H SP E+Q ++
Sbjct: 327 NNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGKNDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPE-AVKQCSNHVRCLMCPSSFHKGDWCIPAGSKEINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKA-----------LVLRTSKWESI--------LNLK---NKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLP-CKCGASNCSGFLGDPPKTASPD----SEPSDKDSILELKKSYNSNNKIDKKKILINKKPNN---TVDL------------------QNFFQKKLVDQE------------CYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMV---CSNHEDLFLSHGSPTESQNGSIN 1100
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000039925.1 (SMESG000039925.1) HSP 1 Score: 403.29 bits (1035), Expect = 1.070e-122 Identity = 268/838 (31.98%), Postives = 398/838 (47.49%), Query Frame = 2
Query: 527 NNAVLQCTGICKRYFHLHCLK----NLKENQPTSKP--NFQCLDCFSGIYHCILCQKV---DKIDDLLACENSDCGRLYHKSCLEMSNFIG-IEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHF-----------------ENKLVKLNA---------------------------HKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFN-----TAQFSSIFKESG-----------GTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANI------IVPPAKLP--PKVQPSICD-CVDNC-PKQDCKNYLNKIECQITQC---PKCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLG--PIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSH-------AQETNIIIPTIKTRKSICLLHKSPPENQTSYLH 2764
NN V CTG C + FH CL+ L +PT+K +C+DC + C +CQK+ DK D+++ C S+CGR YH +CL ++ I + + L+CPSH C +C +D A C V CL CP SFH D C+ AG+ E++ +++ICP+H +N VKLN+ K + WCF C G + C CPAS H C + ++C +C++ R PRYG++ ++K+ YRWWP +IIHP NAP +LK + DG + V F G+N+Y W+ KT + F T + I S G T++DRD+ L++A K + LR+ S+ +N+K K +++ IK N+ I PA L P+ + D C D C P +C N EC C C+NQ+F ++ VF T NRG+ L+T PI K F+ EY+GELI + E+ R+ A + N +FYM+ L G +IDAGP N+SR+MNHSC PN Y + W VNG + G+FAL I + +ELTF+Y + K+ C C ++NC+GFLG P + P+ S+ + ++S + L N +D K ++K+ +N +DL N ++K + + CYRC + C +CP+ YHL C+ L P W CPWH CD CG+ S+ FC C S+C H + N++ + + L H SP E+Q ++
Sbjct: 342 NNLVANCTGGCGQQFHPDCLRLLFDYLTSKEPTTKVINYLKCVDCNRNVRRCFICQKLGKNDKKDEMMKCSTSNCGRYYHSNCLYNGHYQQLITYNRSGSLTCPSHICHACYIDDPE-AVKQCSNHVRCLMCPSSFHKGDWCIPAGSKEINDNYIICPKHLSMGGSAEITVTPFMDCIKNGRVKLNSVNFKLTPFNDPQNKDFWVLEKPLKVSKSKSHNVTWCFLCPDGGKLICCERCPASLHQHCAAIDEIPVVFICDDCQSGRYPRYGDIYWLKIGSYRWWPGQIIHPNNAPEKVLKASHGDGQFLVQFFGTNDYYWMNKTHAFPFEDGDDKTGEMKKIIANSSLDEVTRDTSGNGNTKLDRDYRKSLKIAAKA-----------LVLRTSKWESI--------LNLK---NKPSQYRSIKTNVPIGNVRINKPADLTEIPQCECRPSDKCNDPCGPTSECMNRELMYECHPLVCRNGENCRNQRFMRREYPKQEVFSTDNRGWALRTLEPIKKGAFVNEYVGELIDEAEANRRLKKAHETNVSNFYMMELDGQRIIDAGPAANISRFMNHSCSPNVYTQKWSVNGDTRIGLFALHTIKAGEELTFNYNFFSLGQKKLP-CKCGASNCSGFLGDPPKTASPD----SEPSDKDSILELKKSYNSNNKIDKKKILINKKPNN---TVDL------------------QNFFQKKLVDQE------------CYRCGQNNCEIFCSHQHCPRVYHLQCVSLSNIPKSLWLCPWHCCDDCGRISEYFCSECTTSYCLLHRFNRLVKSSNENMV---CSNHEDLFLSHGSPTESQNGSIN 1115
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000015015.1 (SMESG000015015.1) HSP 1 Score: 291.582 bits (745), Expect = 7.990e-84 Identity = 221/774 (28.55%), Postives = 335/774 (43.28%), Query Frame = 2
Query: 509 CEIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNF-QCLDCFSGIYHCILCQKVDKIDD---LLACENSDCGRLYHKSCLEMSNFIGI-EIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQH---------------------------FENKLVKLN---------AHKPFHPAWCFKCFKTGVKLHCNYCPASYHIECVSDYSEESRYVCYNCRNFRQPRYGEVLFVKVHQYRWWPCEIIHPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRVAGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKTVKFKLIKANIIVPPAKLPPKVQPSI--CDCVDNCPKQDCK------NYLNKIECQITQC---PKCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRC---FDGGNLVLCDKMNCPKTYHLSCLGLEEA--PSGTWYCPWHFCDICGQPSKLFCVRCPASFCD 2659
C E ++QC FH+ CL+ L+ + T + +CL+C GI C C K+ I + + C C + +H +CLE + + + L CP H C C + + + C KL+ C+ CP +FH D C+ AG+ EL+ +ICP+H + N L K++ KP + WCFKC + G L C CPA+YH +C ++ C +C +F YGE++++K + WWP +I+H N P NI +G + V F GS +Y W ++ G +++ + + Y NI L + + + +T EE + + + + + I+ N P +L KV P C+C+ PK DC N +K EC C KCKNQ F + F ++RG+GLK I F+ EY+GE+IT ESE R+L A + N DFY + L +IDA NLSR++N+SCDPN E WIVN + G+FAL++I +ELTF Y + C C S NC+GFLG +P ++++ S S SK D ++ + + + F+ DK+S C+RC D + ++C C KTYH CL L A +W CP H+CD+C +PS F S+C+
Sbjct: 199 CRYCLETKNIVQCNKCLFNNFHVKCLEFLQNSIETKINDLDRCLECSLGIIRCYACYKIVDISNEQGFMRCIIKTCTKWFHTNCLETGPMLEMTKFPKPGQLVCPCHICHKCELVNPS-PKYRCTKLIVCIMCPATFHTGDWCIPAGSVELNTGEIICPRHLVDLNFSMNIMVPPFVARVKSDLQERIYGNTLTKISEPMTITPSTVTKPTNVNWCFKCGEGGELLCCETCPAAYHFKCTDLKEIPQKFYCPDCASFCYRSYGEIVWIKCGTHPWWPGQILHLENVPKNIAAKKHANGQFVVQFFGSRDYMW------------------RDHGNVFLYEKEDECNSKTS---KYRYNNIFLERI--KEAAIGYVTREEKWQSGSCDHVMNSKI-YNKIQVNKC--PLELRRKVVPETPHCNCISFDPKSDCSIGSGCFNVASKCECDPQICNLGDKCKNQNFVKRIYPKQYTFWANDRGWGLKADEFIKTKQFVNEYIGEIITMEESEKRILWANENNISDFYFMELDNGRLIDARQFSNLSRFINNSCDPNLVAEKWIVNREHRIGLFALRDIQKGEELTFQYNLQNK-SSNRIVCKCFSVNCSGFLG------EAPKMAKVSKLKSDTSKK-----------SKGDTTESESSC-----------------------------KSFLTDKNSNSQ-------CFRCGEIIDMLSSIVCSVGPCMKTYHSVCLNLNMANYVQSSWICPHHYCDVCARPSHHFSSNTTESYCN 891
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000051054.1 (SMESG000051054.1) HSP 1 Score: 245.358 bits (625), Expect = 1.204e-66 Identity = 205/786 (26.08%), Postives = 347/786 (44.15%), Query Frame = 2
Query: 350 SPSPNLKKYRKDSLHNENSVIKIEKESVPIFQMEIQRLVASPAQYSFQSVCAVC-EIYTENNAVLQCTGICKRYFHLHCLKNLKENQPTSKPNFQCLDCFSGIYHCILCQ--KVDKIDDLLACENSDCGRLYHKSCLEMSNFIGIEIHDNKILSCPSHYCISCVREDATFAQNPCKKLVECLRCPLSFHCNDLCMAAGAYELSLSHVICPQHFENKLVKLNAHKPFHPAWCFKCFKTGVKLHCNYCPASYHIEC--VSDYSEESR-YVCYNCRNFRQPRY-GEVLFVKVHQYRWWPCEII-HPRNAPMNILKLNRPDGTYPVLFLGSNEYQWVAKTRSIDFNTAQFSSIFKESGGTTRMDRDFSSGLRV---AGKIHQVYVNILLMHVPLRSISASSMTAEELYPYVNVKEINQKT-VKFKLIKANIIVPPAK-LPPKVQPSICDCVDNCPKQDCKNYLNKIECQITQCPKCKNQQFTNVDHKNIAVFKTSNRGFGLKTTIPINKNDFIIEYLGELITKNESELRMLNAKKFNAKDFYMIHLTGDLVIDAGPKGNLSRYMNHSCDPNCYLENWIVNGYPKKGVFALKEIGSDQELTFDYRISGVIMKEDAFCLCSSNNCTGFLGPIKSLPNSPVKSQLTSRNSSISLTSGINEKPLVDISKDDLSKQDDNISKAIDLISEAPILNESFESFKDIPLNALEEKFIKDKDSVESKTIHENFCYRCFDGGNLVLCDKMNCPKTYHLSCLGLEEAPSGTWYCPWHFCDICGQPSKLFCVRCPASFCDSHA 2668
SPS L +++L + +++K ++ MEI +L+A+ ++C C + + N+ C G C+ +HL C +L S N +C++C + C +C+ K K L+ C S C +H +C++ NFI + +I+ CP+H C++C RED N LV C+RCP+S+H N LC+ AG +S +IC +HFE+ + CF CF L C C +H +C ++ Y++ + +VC C+ QP + G++++ ++ W P EI+ H R A I N V+ G F +A+ + G + +S +V A ++ VY N P S ++ E+L T K++ I N+ K + P ++C C + K P +F NR F +K ++K D I E+ G LI+++++ +Y+ L +L +D +GN R+++HSC+ N L W V G + V AL+ + +++E+T DY+ SG+++K + C C + NC GP N ++I + + ++D S + + SK + + + I+ +SF + + + +++D V C+RC G L+ C+K NC K YHL C+GL +A G WYCP HFC CGQ + +FC C S C +H+
Sbjct: 309 SPSLQLNSINRETL--DTALLK--SVTIKNSSMEIFKLIANNELSIMSNICHQCLQPFKPNDKQKSCKGDCEATYHLMC--SLTHKLFRSDDNNKCVNCVPKEFLCCICKNSKYMKKMFLVKCSKSGCPLYFHATCMKFLNFIDNTSDEKEIVECPNHSCLTCFREDNKHPCNNLGALVTCIRCPISYHNNMLCIPAGCRVISERKIICHRHFESNSSSSSN-----LTRCFVCFNENATLKCCRCRGVFHPKCMGLATYADLLKDFVCSTCK-LEQPMFHGQLVWTEIDNV-WTPAEIVAHKRAAGQTIQHNNHKSLVVRVIENGC-------------FRSAEPCELVTFLIGEIVLKDSMTSNKKVVESAKIMNMVYFNWRKRMRPFFSEKCPTIDQEDLVKLSTTSLSKPLTNSKYEYITKNVYDENVKNIIPSKPMTVCSCSLENTHHNSFCVSGKFTEGFKTKPIVTENEF-------------PNRSF-VKVYESLSKGDMIGEFTGRLISRDKAVEISSKENGLLNPSYYIYQLEENLFLDCDKQGNEWRFLSHSCNANAELVCWNVAGELRVSVVALRSL-ANEEITIDYQKSGLVLKHEYLCNCRAYNCRKSFGPTSVFANK----------TNIIVPRCCIDNRIIDESAINHCQSQ---SKPKPVTNRSSIVRMKLDSFAGVKIEEIPVVDNRERDRVT--------CHRCGYHGELITCNKTNCKKRYHLQCVGLSDASKGLWYCPKHFCIECGQVASIFCGSCSTSHCRNHS 1032 The following BLAST results are available for this feature:
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 2
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30023718 ID=SMED30023718|Name=Histone-lysine N-methyltransferase|organism=Schmidtea mediterranea sexual|type=transcript|length=3104bpback to top protein sequence of SMED30023718-orf-1 >SMED30023718-orf-1 ID=SMED30023718-orf-1|Name=SMED30023718-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=906bp MTSKSKNITSNSNKDSYLSFDDDNSLDSIEDETGFQYFLYDLKVKNDAGKback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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