Acid-sensing ion channel 1

Overview
NameAcid-sensing ion channel 1
Smed IDSMED30023659
Length (bp)1939
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Acid-sensing ion channel 1 (SMED30023659) t-SNE clustered cells

Violin plots show distribution of expression levels for Acid-sensing ion channel 1 (SMED30023659) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Acid-sensing ion channel 1 (SMED30023659) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Acid-sensing ion channel 1 (SMED30023659) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30023659

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parapharyngeal regionSMED30023659h1SMcG0021014 SmedASXL_009885SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
nervous systemSMED30023659h1SMcG0021014 dd_Smed_v4_12878_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30023659h1SMcG0021014 dd_Smed_v4_12878_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30023659h1SMcG0021014 dd_Smed_v4_12878_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
anterior sideSMED30023659h1SMcG0021014 dd_Smed_v4_12878_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Human
Match: SCNN1B (sodium channel epithelial 1 beta subunit [Source:HGNC Symbol;Acc:HGNC:10600])

HSP 1 Score: 77.0258 bits (188), Expect = 4.580e-14
Identity = 86/370 (23.24%), Postives = 152/370 (41.08%), Query Frame = 2 
Query:  506 QFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYI-------FEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILD 1594
            + S+PG  +I  C +  + C + NFT I    YG C+ FN     MT  A   S   G     ++IL  G       ++D    +   +G+  M+HE +SYP+I         G       +VD K+ R   EP   PC    +     +  ++ + TY      C+ +  Q+ + ++CNC    YP+     G ++C +      A    +C  +   ++ + E  + +C K+ C+ + Y+  IS A +P+  E + + ++                                L Q  DQ     L++    +  + L +  Q      +EE     I  LLS++GG  G W+G S++ + E  ++I+D
Sbjct:  210 EMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFN---WGMTEKALP-SANPGTEFGLKLILDIG-------QEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVD-KLQR-MGEP-YSPCTVNGSEVPVQNFYSDYNTTY--SIQACLRSCFQDHMIRNCNCGHYLYPLP---RGEKYCNNRDFPDWA----HCYSDLQMSVAQRETCIGMC-KESCNDTQYKMTISMADWPS--EASEDWIFH------------------------------VLSQERDQSTNITLSR----KGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIID 519
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Human
Match: SCNN1B (sodium channel epithelial 1 beta subunit [Source:HGNC Symbol;Acc:HGNC:10600])

HSP 1 Score: 77.0258 bits (188), Expect = 4.858e-14
Identity = 86/370 (23.24%), Postives = 152/370 (41.08%), Query Frame = 2 
Query:  506 QFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYI-------FEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILD 1594
            + S+PG  +I  C +  + C + NFT I    YG C+ FN     MT  A   S   G     ++IL  G       ++D    +   +G+  M+HE +SYP+I         G       +VD K+ R   EP   PC    +     +  ++ + TY      C+ +  Q+ + ++CNC    YP+     G ++C +      A    +C  +   ++ + E  + +C K+ C+ + Y+  IS A +P+  E + + ++                                L Q  DQ     L++    +  + L +  Q      +EE     I  LLS++GG  G W+G S++ + E  ++I+D
Sbjct:  237 EMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFN---WGMTEKALP-SANPGTEFGLKLILDIG-------QEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVD-KLQR-MGEP-YSPCTVNGSEVPVQNFYSDYNTTY--SIQACLRSCFQDHMIRNCNCGHYLYPLP---RGEKYCNNRDFPDWA----HCYSDLQMSVAQRETCIGMC-KESCNDTQYKMTISMADWPS--EASEDWIFH------------------------------VLSQERDQSTNITLSR----KGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIID 546
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Human
Match: SCNN1B (sodium channel epithelial 1 beta subunit [Source:HGNC Symbol;Acc:HGNC:10600])

HSP 1 Score: 77.0258 bits (188), Expect = 5.021e-14
Identity = 86/370 (23.24%), Postives = 152/370 (41.08%), Query Frame = 2 
Query:  506 QFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYI-------FEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILD 1594
            + S+PG  +I  C +  + C + NFT I    YG C+ FN     MT  A   S   G     ++IL  G       ++D    +   +G+  M+HE +SYP+I         G       +VD K+ R   EP   PC    +     +  ++ + TY      C+ +  Q+ + ++CNC    YP+     G ++C +      A    +C  +   ++ + E  + +C K+ C+ + Y+  IS A +P+  E + + ++                                L Q  DQ     L++    +  + L +  Q      +EE     I  LLS++GG  G W+G S++ + E  ++I+D
Sbjct:  282 EMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFN---WGMTEKALP-SANPGTEFGLKLILDIG-------QEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVD-KLQR-MGEP-YSPCTVNGSEVPVQNFYSDYNTTY--SIQACLRSCFQDHMIRNCNCGHYLYPLP---RGEKYCNNRDFPDWA----HCYSDLQMSVAQRETCIGMC-KESCNDTQYKMTISMADWPS--EASEDWIFH------------------------------VLSQERDQSTNITLSR----KGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIID 591
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Human
Match: ASIC5 (acid sensing ion channel subunit family member 5 [Source:HGNC Symbol;Acc:HGNC:17537])

HSP 1 Score: 71.2478 bits (173), Expect = 2.483e-12
Identity = 111/511 (21.72%), Postives = 199/511 (38.94%), Query Frame = 2 
Query:  143 AQRTTVHGVNHLSQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDH-EMFEFPEISFCNLNPIFVPPSGTKEYQNLLRW-----IAEYPKVKNNQT---LASSYLASLSDFL---YIQKKQFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIY-RGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFEGYLL----DFFSVVDLKITRKFHEP----KLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCV---MEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCD----HSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLIL 1591
            A  T+ HG++++ Q +++  R+ WL++V  +    T  ++  +  Y  +   ++    + E  EFP ++FCNLN  F   +  K       W     +    ++  N T    A+ + AS  +F    +I+ K F +   S +  C +  K C+  +F  +    YG CFTFN       +  +K+S+  RG    F V      D P     D        +GI+F++H P+  P  F+G  L       + V ++  +  H+     +  P IK + + +Y               + C+       +KK C CV   +  Y I  +      C S +L H                        + +KDLC     +SS      + +YPA                         + S   S+  +   S  L Q+          + ++  N + + +    L     ++ +   +S LL+D+GG +GL+ GASLIT+ E+ + + 
Sbjct:   42 AISTSFHGIHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNR-FQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGF-YLNNSTLLDCEFFGKPCSPKDFAHV-FTEYGNCFTFNHGE--TLQAKRKVSVSGRGLSLLFNVNQEAFTDNPALGFVD--------AGIIFVIHSPKKVPQ-FDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPNIKLQNFSSYST-------------SGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDH------------------------IEFKDLCTVGTHNSSCPVSCEEIEYPAT-----------------------ISYSSFPSQKALKYLSKKLNQS----------RKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLF 468
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Human
Match: ASIC2 (acid sensing ion channel subunit 2 [Source:HGNC Symbol;Acc:HGNC:99])

HSP 1 Score: 56.6102 bits (135), Expect = 9.617e-8
Identity = 68/307 (22.15%), Postives = 123/307 (40.07%), Query Frame = 2 
Query:  713 GIDFPLEMKQDPHHTV-------TMPSGILFMMHEPQSYPYIFE---GYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVD--PITNTSKTYLGRWADC-IYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILD 1594
            G++  L+++QD +  +       T  +G+   +H     P+I E   G    F + V  +  R  + P   P  + R+    +D  P+ + +   +    DC    I++N     CNC M   P         FC       + E  K C   A   + + +    LC +  C+ + Y   +S  K P+                  +   +KFNKS+                             ++  N ++L +  ++L  + +E+ + Y ++ LL DIGG +GL++GAS++T+ ELFD I +
Sbjct:  267 GLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPP--PWGECRSSEMGLDFFPVYSITACRI----DCETRYIVEN-----CNCRMVHMP-----GDAPFC-------TPEQHKECAEPALGLLAEKDSNYCLC-RTPCNLTRYNKELSMVKIPS--------------KTSAKYLEKKFNKSE----------------------------KYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYE 507
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Celegans
Match: deg-1 (Degenerin deg-1 [Source:UniProtKB/Swiss-Prot;Acc:P24585])

HSP 1 Score: 59.6918 bits (143), Expect = 5.206e-9
Identity = 90/435 (20.69%), Postives = 164/435 (37.70%), Query Frame = 2 
Query:  359 NPIFVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLASLSDFLYIQKKQFSHPGWSLIAHCRYQTKVCTWINFTPITLWP-YGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFE-GYLLDFFSVVDLKITRKFHEPKLKP---CIKTRTYYTYVDPITNTSKTYLG---RWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNA--FKAIFKNEVKMNLCY-KDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAEILYNNPYYQ 1630
            NP  +   G   +Q +   +A   + K N       +A+LSD   I   Q  H     I  C +  K C       + + P +G CFTFN +  N    ++   +Y             GI   L +    + + +  SG+   +H P  YP+    GY           I +K  +    P   C++T+        + + +  Y G       C  +  QN +   C+C   ++P+     G   C S+    +   ++  +G+   F  I +   KM+ C  K  C+   ++   S +K+P+                               +  L +   +T  +    +R           N  ++ V  + L  + ++E E Y +  L++D GG +GLWLG S+ITV E+  L++D   + + + + +
Sbjct:  387 NPETIKAMG---FQGMTDGVAMLTRAKENLMFT---MAALSDKQRIALSQSKH---EFIEMCSFNGKECDIDEDFRLHVDPEFGNCFTFNYDVNNNYTSSRAGPMY-------------GIRVLLFVNTSDYMSTSESSGVRLAIHPPTEYPFPDTFGYSAPVGFASSFGIKKKVMQRLPAPYGECVETKK-------VVDRNYIYAGYDYHPEGCHRSCFQNGLIDDCSCGDPRFPVP---EGYRHC-SAFNATARTCLEKNIGSVGDFHHITQ---KMDKCVCKQSCEEIIHEVTFSCSKWPS------------------------------GATDLGDCDGMTESECEQYYR----------LNAAMIEVFYEQLNYELLQESEAYGLVNLIADFGGHLGLWLGFSVITVMEVCVLLVDMISLFFKSRHEE 745
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Celegans
Match: deg-1 (Degenerin deg-1 [Source:UniProtKB/Swiss-Prot;Acc:P24585])

HSP 1 Score: 59.6918 bits (143), Expect = 5.206e-9
Identity = 90/435 (20.69%), Postives = 164/435 (37.70%), Query Frame = 2 
Query:  359 NPIFVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLASLSDFLYIQKKQFSHPGWSLIAHCRYQTKVCTWINFTPITLWP-YGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFE-GYLLDFFSVVDLKITRKFHEPKLKP---CIKTRTYYTYVDPITNTSKTYLG---RWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNA--FKAIFKNEVKMNLCY-KDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAEILYNNPYYQ 1630
            NP  +   G   +Q +   +A   + K N       +A+LSD   I   Q  H     I  C +  K C       + + P +G CFTFN +  N    ++   +Y             GI   L +    + + +  SG+   +H P  YP+    GY           I +K  +    P   C++T+        + + +  Y G       C  +  QN +   C+C   ++P+     G   C S+    +   ++  +G+   F  I +   KM+ C  K  C+   ++   S +K+P+                               +  L +   +T  +    +R           N  ++ V  + L  + ++E E Y +  L++D GG +GLWLG S+ITV E+  L++D   + + + + +
Sbjct:  387 NPETIKAMG---FQGMTDGVAMLTRAKENLMFT---MAALSDKQRIALSQSKH---EFIEMCSFNGKECDIDEDFRLHVDPEFGNCFTFNYDVNNNYTSSRAGPMY-------------GIRVLLFVNTSDYMSTSESSGVRLAIHPPTEYPFPDTFGYSAPVGFASSFGIKKKVMQRLPAPYGECVETKK-------VVDRNYIYAGYDYHPEGCHRSCFQNGLIDDCSCGDPRFPVP---EGYRHC-SAFNATARTCLEKNIGSVGDFHHITQ---KMDKCVCKQSCEEIIHEVTFSCSKWPS------------------------------GATDLGDCDGMTESECEQYYR----------LNAAMIEVFYEQLNYELLQESEAYGLVNLIADFGGHLGLWLGFSVITVMEVCVLLVDMISLFFKSRHEE 745
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Celegans
Match: deg-1 (Degenerin deg-1 [Source:UniProtKB/Swiss-Prot;Acc:P24585])

HSP 1 Score: 59.6918 bits (143), Expect = 5.206e-9
Identity = 90/435 (20.69%), Postives = 164/435 (37.70%), Query Frame = 2 
Query:  359 NPIFVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLASLSDFLYIQKKQFSHPGWSLIAHCRYQTKVCTWINFTPITLWP-YGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFE-GYLLDFFSVVDLKITRKFHEPKLKP---CIKTRTYYTYVDPITNTSKTYLG---RWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNA--FKAIFKNEVKMNLCY-KDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAEILYNNPYYQ 1630
            NP  +   G   +Q +   +A   + K N       +A+LSD   I   Q  H     I  C +  K C       + + P +G CFTFN +  N    ++   +Y             GI   L +    + + +  SG+   +H P  YP+    GY           I +K  +    P   C++T+        + + +  Y G       C  +  QN +   C+C   ++P+     G   C S+    +   ++  +G+   F  I +   KM+ C  K  C+   ++   S +K+P+                               +  L +   +T  +    +R           N  ++ V  + L  + ++E E Y +  L++D GG +GLWLG S+ITV E+  L++D   + + + + +
Sbjct:  387 NPETIKAMG---FQGMTDGVAMLTRAKENLMFT---MAALSDKQRIALSQSKH---EFIEMCSFNGKECDIDEDFRLHVDPEFGNCFTFNYDVNNNYTSSRAGPMY-------------GIRVLLFVNTSDYMSTSESSGVRLAIHPPTEYPFPDTFGYSAPVGFASSFGIKKKVMQRLPAPYGECVETKK-------VVDRNYIYAGYDYHPEGCHRSCFQNGLIDDCSCGDPRFPVP---EGYRHC-SAFNATARTCLEKNIGSVGDFHHITQ---KMDKCVCKQSCEEIIHEVTFSCSKWPS------------------------------GATDLGDCDGMTESECEQYYR----------LNAAMIEVFYEQLNYELLQESEAYGLVNLIADFGGHLGLWLGFSVITVMEVCVLLVDMISLFFKSRHEE 745
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Celegans
Match: acd-1 (pep chromosome:WBcel235:I:4103713:4108045:1 gene:WBGene00016064.1 transcript:C24G7.2.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:acd-1)

HSP 1 Score: 59.3066 bits (142), Expect = 6.151e-9
Identity = 57/257 (22.18%), Postives = 107/257 (41.63%), Query Frame = 2 
Query:  146 QRTTVHGVNHLSQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVLSNTYH--DHEMFEFPEISFCNLNPIFVPPSGTKEYQN---------------LLRWIAEYPKVKNNQTLASSYLASLSDFLYIQKKQ-------FSHPGWS---LIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHH------TVTMPSGILFMMHEPQSYPYI 817
            + TT+HG   + Q K +   +FWL++VS +       +F +  +YL    +S+     + +  +FP I+ CNLNPI       K Y N               +++W  E P +       + +  +    LY++          F + G+S   +   C +Q ++      +   L P G CFT + +S      + K S+++   P  +  L   +D  LE + D  +      T +  +G  + +H P + P++
Sbjct:   85 ETTTMHGPKRIFQGK-RWATLFWLIMVSCSLGLLITQVFILASEYLSKPTVSDVSFLINEDGMDFPLITICNLNPI------RKTYVNEINKTGEVSPPMINYMMKWFTEIPTLIGGADRPTLHEGNEELKLYMKNHLNFTVDSFFMNSGFSCPDIFKLCSFQGEIFDCCTLSTEVLTPLGKCFTLDLSS------STKASMHKQTEPGIQAGLAITLDAHLEEQFDGSNGMDALFTNSFVNGFRYFVHPPNTIPHL 328
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Celegans
Match: F58G6.8 (pep chromosome:WBcel235:IV:9643422:9644268:1 gene:WBGene00010278.1 transcript:F58G6.8.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F58G6.8)

HSP 1 Score: 51.6026 bits (122), Expect = 3.543e-7
Identity = 24/74 (32.43%), Postives = 37/74 (50.00%), Query Frame = 2 
Query:  143 AQRTTVHGVNHLSQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDHEMFEFPEISFCNLNP 364
             +  T+HGV H++Q       I W +I+  +A+ F    + I   YL + V+ N     +   FP I+FCN NP
Sbjct:   97 GETATIHGVPHMAQAHTVIAIIVWSIILIVSAVAFVYMFYSIAASYLAFNVVVNLNTGLDSEPFPSITFCNTNP 170
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Zebrafish
Match: asic1b (acid-sensing (proton-gated) ion channel 1b [Source:NCBI gene;Acc:407672])

HSP 1 Score: 67.781 bits (164), Expect = 2.360e-11
Identity = 109/542 (20.11%), Postives = 196/542 (36.16%), Query Frame = 2 
Query:  107 ADPKTYADSSFNA------QRTTVHGVNHLSQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDH-EMFEFPEISFCNLNPIFVPPSGTK-EYQNLLRWIAEYPKVKNNQTLASSYLASLSDFLYIQK-----------------------------KQFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTV-------TMPSGILFMMHEPQSYPYIFE---GYLLDFFSVVDLKITR-KFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLI 1588
            A PK  A+ S         + TT HG+ H+    +   R+ WL+    A           +   L   V +  +  + +   FP ++ CN N I +P    K +  +  RW+  + K           LASL D   +                                +  H    ++ +CR+Q ++C   NF+ I    YG C+TFN            L   +G   N       G++  L+++QD +  V       T  +GI   +H     P+I +   G    F + V  +  R  +  P    C  T     + +  + T+         C  +     + ++CNC M   P    +           C   +Y K C   A   + + +    +C +  C+ + Y   +S  + P+                  +   +K+NK++                             ++  N M+L +  ++L  + +E+ + Y ++ LL DIGG +GL++GAS++T+ ELFD +
Sbjct:    6 APPKPRAEGSLKEAGKLFLKHTTFHGLRHVFLSGSYPRRVAWLLAFLTALALLFTWSSNRVRYLLSSPVYTKAHMVYAKRLVFPAVTICNKN-ILLPRRMKKPDIFSAGRWLGIFGKNWQVSAAVRDALASLDDGTNVDPPWSPFSRILEFNHFLPPPRDSQPSMRQLLDRLGHQLEEMLLYCRFQGQLCGPRNFSTI-FTRYGKCYTFNSGQDGRPL----LITTKGGMGN-------GLEIMLDIQQDEYLPVWGETDETTFEAGIKVQIHTQDEPPFIDQLGFGVAPGFQTFVSCQEQRLTYLPPPWGDCKATPIDSDFFNTYSITA---------CRIDCETRYLVENCNCRMVHMPGDAPY-----------CTPEQY-KECADPALDFLVERDNDYCVC-ETPCNMTRYGKELSFVRIPS--------------KASAKYLAKKYNKTE----------------------------QYISDNIMVLDIFFEALNYETIEQKKAYELAGLLGDIGGQMGLFIGASILTILELFDYL 470
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Zebrafish
Match: asic4b (acid-sensing (proton-gated) ion channel family member 4b [Source:NCBI gene;Acc:407667])

HSP 1 Score: 56.6102 bits (135), Expect = 6.575e-8
Identity = 25/71 (35.21%), Postives = 49/71 (69.01%), Query Frame = 2 
Query: 1391 RKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAE 1603
            RK   +++++  NF++L +  ++L  + +E+ + Y I+ LL DIGG +GL++GAS++T+ E+ D I + A+
Sbjct:  398 RKYQKSEEYIRDNFLILDIFFEALNYETIEQKKAYDIAGLLGDIGGQMGLFIGASILTILEILDYIYEVAK 468
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Zebrafish
Match: asic4a (acid-sensing (proton-gated) ion channel family member 4a [Source:NCBI gene;Acc:407668])

HSP 1 Score: 55.0694 bits (131), Expect = 1.170e-7
Identity = 25/79 (31.65%), Postives = 51/79 (64.56%), Query Frame = 2 
Query: 1352 NSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLI 1588
             S+  L + YD+      ++D++  NF++L +  ++L  + +E+ + Y ++ LL DIGG +GL++GAS++T+ E+ D +
Sbjct:  195 GSARYLSRKYDK------SEDYIRDNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASVLTILEILDYV 267
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Zebrafish
Match: asic4a (acid-sensing (proton-gated) ion channel family member 4a [Source:NCBI gene;Acc:407668])

HSP 1 Score: 55.0694 bits (131), Expect = 1.800e-7
Identity = 25/79 (31.65%), Postives = 51/79 (64.56%), Query Frame = 2 
Query: 1352 NSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLI 1588
             S+  L + YD+      ++D++  NF++L +  ++L  + +E+ + Y ++ LL DIGG +GL++GAS++T+ E+ D +
Sbjct:  387 GSARYLSRKYDK------SEDYIRDNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASVLTILEILDYV 459
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Zebrafish
Match: asic1a (acid-sensing (proton-gated) ion channel 1a [Source:NCBI gene;Acc:791696])

HSP 1 Score: 55.0694 bits (131), Expect = 1.983e-7
Identity = 23/63 (36.51%), Postives = 44/63 (69.84%), Query Frame = 2 
Query: 1406 NKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILD 1594
            ++ ++  N M+L V  ++L  + +E+ + Y ++ LL DIGG +GL++GAS++T+ ELFD + +
Sbjct:  399 SEKYITENVMVLDVFFEALNYETIEQRKAYEVAGLLGDIGGQMGLFIGASILTILELFDYLYE 461
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Xenopus
Match: ASIC1 (acid sensing ion channel subunit 1 [Source:NCBI gene;Acc:100489966])

HSP 1 Score: 84.3445 bits (207), Expect = 1.607e-16
Identity = 107/497 (21.53%), Postives = 197/497 (39.64%), Query Frame = 2 
Query:  143 AQRTTVHGVNHL-SQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVLS--NTYHDHEMFEFPEISFCNLNPIFVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLASLSDF---LYIQKKQFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTV-------TMPSGILFMMHEPQSYPYIFE---GYLLDFFSVVDLKITR-KFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFD 1582
            A   T+HG+NH+ ++      R+ W +    +   F   +++ +  Y  Y  L+  +      MF FP ++FCN N  F P   ++   + L ++A  P +   +   +++  + SD    LY    + SH    ++  CRYQ   C   +F P+    YG C+TFN      +     L   +G   N       G++  L+++QD +  V       +  +GI   +H     P+I +   G    F + V  +  R  +  P    C  +     + D  + ++         C  +     + ++CNC M   P         +C       + E  K C   A   + + +    +C +  C+ + Y   +S  K P+                      +K+NKS+                             ++  N ++L +  ++L  + +E+ + Y ++ LL DIGG +GL++GAS++TV ELFD
Sbjct:   47 ASNCTLHGLNHIVTEGAWGPRRVIWTVSFLLSLSLFLSQVWERVAYYKTYPRLTAIDEMVAKRMF-FPAVTFCNCNR-FRP---SQLSADELLYLA--PLIGAPEDGEATFTQTPSDSKYDLYEITDRTSHQLSDMMLECRYQGAECDADDFIPV-FTRYGKCYTFNSGRNGRS----PLVTTKGGTGN-------GLELMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLTYLPPPWGDCKSSAMDSEFFDTYSISA---------CRIDCETRYLVENCNCRMVHMP-----GDAAYC-------TPELYKECADPALDFLVEKDNDFCVC-ETPCNMTRYGKELSMVKIPS--------------KASARYLAKKYNKSE----------------------------QYIAENILVLDIFFEALNYETIEQKKAYEVAGLLGDIGGQMGLFIGASILTVLELFD 460
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Xenopus
Match: ASIC5 (acid sensing ion channel subunit family member 5 [Source:HGNC Symbol;Acc:HGNC:17537])

HSP 1 Score: 57.3806 bits (137), Expect = 5.565e-8
Identity = 124/532 (23.31%), Postives = 209/532 (39.29%), Query Frame = 2 
Query:  143 AQRTTVHGVNHL----SQVKNQRGRI-FWLMIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDH----EMFEFPEISFCNLNPIFVPPSGTKEYQNLLRWIAEY-----PKVKNNQTLAS--SYLASLSDFLYIQK----KQFS-----HPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFEGYLLDFFSVVDLKIT-RKFHE-------PKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDL----CDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAEILYNNPYY 1627
            A  T+ HGV++L       KN + R   W  +VS   +   +  +Q+  + + Y     T   +    E  +FP I+FCNLN        TK   NL   IA +       V +  ++AS    +  ++DFL + K    K+F+     +   S +  C +    C   +F  I    YG C+TFN N+++M +  +  +  RG    F++   +  D P     D        +GI F++H P   P  F+G  L   + +   ++ R+F          +  P +K + +  Y         TY G   +C    IQNE    C C+    P  +  NG E C    L        NC+  A   I K+E+     Y       C+ + +   IS + +P+                         +K+     A ++ S+L +R                  N + + +    +    +++ +    S LLS+IGG +GL+ GAS+IT+ E+        E L+ N Y+
Sbjct:   41 ATSTSFHGVHNLVENGGSGKNSKFRTAIWTSVVSVFII---MACWQVCTRVINYFSWPTTTSVNVQYVENIDFPAITFCNLNRF-----QTKAVNNLS--IAFFLWNIVSAVLHFTSIASDPGEMQEVTDFLKLNKNFSIKEFTKNYGFYLNNSTLLKCSFFGYPCYPEDFEHI-FTEYGNCYTFNYNTVSMNK--RITTAGRGLSVLFDIKQTEFTDEPSLGFVD--------AGISFVLHSPLVPPR-FDGLGLHSPAGMHAHVSMRRFKTVIQEHPWGECNPSLKLKYHEIY--------STY-GCLQECKSYYIQNE----CGCI----PFLLPGNGKE-CDLQQL-------YNCVSRALYTIEKSELCSMGTYNSTCPVPCEETDFPATISYSTFPS-------------------------DKAAQFLSAKLSKSALYMRN-----------------NLVYIDIKYHEMNYKIMKQQKALTASELLSNIGGQLGLFCGASMITIIEIL-------EYLFTNSYW 476
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Xenopus
Match: ASIC4 (acid sensing ion channel subunit family member 4 [Source:NCBI gene;Acc:100486325])

HSP 1 Score: 56.9954 bits (136), Expect = 6.353e-8
Identity = 27/84 (32.14%), Postives = 53/84 (63.10%), Query Frame = 2 
Query: 1391 RKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAEILYNNPYYQYKKM 1642
            RK   N+ ++  NF++L +  ++L  + +E+ + Y +  LL DIGG +GL++GAS +T+ E+ D + +  ++L+   YY+ K +
Sbjct:  351 RKYNKNETYIRENFLVLDIFFEALNYETIEQKKAYDLPSLLGDIGGQMGLFIGASFLTILEILDYMYEVIQVLFY--YYREKGI 432
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Xenopus
Match: cspg4 (chondroitin sulfate proteoglycan 4 [Source:Xenbase;Acc:XB-GENE-5893460])

HSP 1 Score: 55.0694 bits (131), Expect = 2.613e-7
Identity = 31/96 (32.29%), Postives = 57/96 (59.38%), Query Frame = 2 
Query: 1310 KFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDS 1597
            ++NK     K     S+  L + +++  K +L+      N ++L V  ++L  + +E+ + Y ++ LL DIGG +GL++GAS++T+ ELFD I +S
Sbjct:  397 RYNKELSMVKIPSKTSAKYLEKKFNKSEKYILD------NILVLDVFFEALNYETIEQRKAYEVAGLLGDIGGQMGLFIGASILTILELFDYIYES 486
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Xenopus
Match: cspg4 (chondroitin sulfate proteoglycan 4 [Source:Xenbase;Acc:XB-GENE-5893460])

HSP 1 Score: 54.6842 bits (130), Expect = 3.346e-7
Identity = 33/118 (27.97%), Postives = 65/118 (55.08%), Query Frame = 2 
Query: 1310 KFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAEILYNNPYYQYKKMSTGVSKK 1663
            ++NK     K     S+  L + +++  K +L+      N ++L V  ++L  + +E+ + Y ++ LL DIGG +GL++GAS++T+ ELFD I +    L +  +   +K+ T +  +
Sbjct:  397 RYNKELSMVKIPSKTSAKYLEKKFNKSEKYILD------NILVLDVFFEALNYETIEQRKAYEVAGLLGDIGGQMGLFIGASILTILELFDYIYEVITFLKSCEHACRRKLYTTLDHR 508
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Mouse
Match: Scnn1b (sodium channel, nonvoltage-gated 1 beta [Source:MGI Symbol;Acc:MGI:104696])

HSP 1 Score: 64.6994 bits (156), Expect = 2.536e-10
Identity = 82/357 (22.97%), Postives = 142/357 (39.78%), Query Frame = 2 
Query:  530 LIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHT-VTMPSGILFMMHEPQSYPYIFE-------GYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFEL 1576
            +I  C + T+ C+  NFTPI    YG C+ FN     MT             P  E     G+   L++ Q+ +   +   +G   M+HE ++YP+I E       G       +VD K+ RK  EP   PC    +     +  +  + TY      C+++  Q+ + ++C+C    YP+     G ++C +      A     C  N   ++ + E  +++C K+ C+ + Y+  IS A +P+    +    W+                               L Q  DQ     L++    +  + L +  Q      +EE     I  LLS++GG  G W+G S++ + E 
Sbjct:  243 IILACLFGTEPCSHRNFTPIFYPDYGNCYIFN---WGMTE-----ETLPSANPGTEF----GLKLILDIGQEDYVPFLASTAGARLMLHEQRTYPFIREEGIYAMAGTETSIGVLVD-KLQRK-GEP-YSPCTMNGSDVAIKNLYSVYNTTY--SIQACLHSCFQDHMIRNCSCGHYLYPLP---EGEKYCNNRDFPDWAY----CYLNLQMSVTQRETCLSMC-KESCNDTQYKMTISMADWPSEASED----WILH----------------------------VLSQERDQSSNITLSR----KGIVKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEF 538
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Mouse
Match: Asic2 (acid-sensing (proton-gated) ion channel 2 [Source:MGI Symbol;Acc:MGI:1100867])

HSP 1 Score: 56.9954 bits (136), Expect = 5.183e-8
Identity = 68/307 (22.15%), Postives = 123/307 (40.07%), Query Frame = 2 
Query:  713 GIDFPLEMKQDPHHTV-------TMPSGILFMMHEPQSYPYIFE---GYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVD--PITNTSKTYLGRWADC-IYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILD 1594
            G++  L+++QD +  +       T  +G+   +H     P+I E   G    F + V  +  R  + P   P  + R+    +D  P+ + +   +    DC    I++N     CNC M   P         FC       + E  K C   A   + + +    LC +  C+ + Y   +S  K P+                  +   +KFNKS+                             ++  N ++L +  ++L  + +E+ + Y ++ LL DIGG +GL++GAS++T+ ELFD I +
Sbjct:  267 GLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPP--PWGECRSSEMGLDFFPVYSITACRI----DCETRYIVEN-----CNCRMVHMP-----GDAPFC-------TPEQHKECAEPALGLLAEKDSNYCLC-RTPCNLTRYNKELSMVKIPS--------------KTSAKYLEKKFNKSE----------------------------KYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYE 507
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Mouse
Match: Asic4 (acid-sensing (proton-gated) ion channel family member 4 [Source:MGI Symbol;Acc:MGI:2652846])

HSP 1 Score: 56.225 bits (134), Expect = 9.890e-8
Identity = 29/93 (31.18%), Postives = 54/93 (58.06%), Query Frame = 2 
Query: 1391 RKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLIL----DSAEILYNNPYYQYKKMSTGVS 1657
            RK   N+ ++  NF++L V  ++L  + +E+   Y +S LL D+GG +GL++GAS++T+ E+ D I     D  + ++  P    +  + G+S
Sbjct:  400 RKYNRNETYIRENFLVLDVFFEALTSEAMEQQAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGGIS 492
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Mouse
Match: Asic4 (acid-sensing (proton-gated) ion channel family member 4 [Source:MGI Symbol;Acc:MGI:2652846])

HSP 1 Score: 56.225 bits (134), Expect = 1.061e-7
Identity = 29/93 (31.18%), Postives = 54/93 (58.06%), Query Frame = 2 
Query: 1391 RKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLIL----DSAEILYNNPYYQYKKMSTGVS 1657
            RK   N+ ++  NF++L V  ++L  + +E+   Y +S LL D+GG +GL++GAS++T+ E+ D I     D  + ++  P    +  + G+S
Sbjct:  381 RKYNRNETYIRENFLVLDVFFEALTSEAMEQQAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGGIS 473
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Mouse
Match: Asic2 (acid-sensing (proton-gated) ion channel 2 [Source:MGI Symbol;Acc:MGI:1100867])

HSP 1 Score: 55.8398 bits (133), Expect = 1.077e-7
Identity = 68/305 (22.30%), Postives = 122/305 (40.00%), Query Frame = 2 
Query:  713 GIDFPLEMKQDPHHTV-------TMPSGILFMMHEPQSYPYIFE---GYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVD--PITNTSKTYLGRWADC-IYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLI 1588
            G++  L+++QD +  +       T  +G+   +H     P+I E   G    F + V  +  R  + P   P  + R+    +D  P+ + +   +    DC    I++N     CNC M   P         FC       + E  K C   A   + + +    LC +  C+ + Y   +S  K P+                  +   +KFNKS+                             ++  N ++L +  ++L  + +E+ + Y ++ LL DIGG +GL++GAS++T+ ELFD I
Sbjct:  216 GLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPP--PWGECRSSEMGLDFFPVYSITACRI----DCETRYIVEN-----CNCRMVHMP-----GDAPFC-------TPEQHKECAEPALGLLAEKDSNYCLC-RTPCNLTRYNKELSMVKIPS--------------KTSAKYLEKKFNKSE----------------------------KYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYI 454
[Close]
BLAST of Acid-sensing ion channel 1 vs. UniProt/SwissProt
Match: sp|Q25011|FANA_CORAP (FMRFamide-activated amiloride-sensitive sodium channel OS=Cornu aspersum OX=6535 PE=2 SV=1)

HSP 1 Score: 105.145 bits (261), Expect = 3.213e-22
Identity = 120/544 (22.06%), Postives = 223/544 (40.99%), Query Frame = 2 
Query:  143 AQRTTVHGVNHLSQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVLS-NTYHDHEMFEFPEISFCNLNPIFVPPSG----TKEYQNLLRWIAEYPKVKNNQTLASSYLASLSDFLYIQKKQFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYR-GYRPNFEVILYKGIDFPLEMKQDPH---HTVTMPSGILFMMHEPQSYPYIFEGYLLDFFSVVD--LKITRKFHEP-KLKPCIKTRTYYTY---VDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFC------------KSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNL-----------CYKDLCDHSSYQTVISQAKYP-------AVEE--RNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLT---LRQAYDQHRKDLLNK--DFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAEILYNN 1618
               +  HG+  +   ++ + ++ W ++V A     T+ L  ++ KYLQ+QV+  +   D    ++P +S CN+ PI +          E QNL+ W+    K +  Q    + + +  + L    K+ SH    ++ HCR+  ++C   NF+      Y  CFTFN          Q+L ++  G      +I     D PL      +   + +   +G+  ++H P S P           S VD  + I   +     LK  + TR  Y Y    + + N  K Y   +  C+    Q  + + C C     P    +N   FC             S+   + +E  +  +   + A  + E K NL           C++  C  +SY   +S + +P       AVE   +           +     + K   +  + K L  N S     L ++Y    K++  +  D + +N + L +  + L + +  ++  Y ++ L +DIGG +GLW+G S++T+ EL +L++    +++N+
Sbjct:   47 GSESNAHGLAKIVTSRDTKRKVIWALLVIAGFTAATLQLSLLVRKYLQFQVVELSEIKDSMPVQYPSVSICNIEPISLRTIRRMYFNNESQNLITWLRFIQKFRFEQDSFMNSIRAFYENLGQDAKKLSHNLEDMLMHCRFNRELCHVSNFSTFFDGNYFNCFTFNS--------GQRLQMHATGPENGLSLIFSVEKDDPLPGTYGVYNFDNNILHSAGVRVVVHAPGSMP-----------SPVDHGIDIPPGYSSSVGLKAILHTRLPYPYGNCTNDMLNGIKQYKYTFFACLQLCKQRLIIQRCGCKSSALPEVPSYNAT-FCGVIKDWQEINRNHSNEDHNQSEEDRAFIPTPYLACEEREQK-NLNNDRTYELSCGCFQP-CSETSYLKSVSLSYWPLEFYQLSAVERFFKQERQAGQNHFMKTAYEYLEKL--AHPSQKHLARNDSHMDDILSKSYSLSEKEMAKEASDLIRQNMLRLNIYLEDLSVVEYRQLPAYGLADLFADIGGTLGLWMGISVLTIMELIELVIRLTGLVFNS 566
[Close]
BLAST of Acid-sensing ion channel 1 vs. UniProt/SwissProt
Match: sp|Q9R0W5|ASIC5_RAT (Acid-sensing ion channel 5 OS=Rattus norvegicus OX=10116 GN=Asic5 PE=1 SV=1)

HSP 1 Score: 77.411 bits (189), Expect = 1.166e-13
Identity = 112/521 (21.50%), Postives = 208/521 (39.92%), Query Frame = 2 
Query:  143 AQRTTVHGVNHLSQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDH----EMFEFPEISFCNLNPIFVPPSGTKEYQNLLRW-----IAEYPKVKNNQT--------LASSYLASLSDFLYIQKKQFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIY-RGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFEGYLLD----FFSVVDLKITRKFHEP----KLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDL--------CDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKD--FVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDS 1597
            A  T+ HG+++++Q +N+  ++ WL +V  +    ++ ++QI  + + Y +   T        E  EFP ++FCNLN  F   + ++       W     +    ++  N T        +AS    S+++F+       +H     + HC +  K C   +F  +    YG CFTFN      ++   K+S+  RG +   +V   +  D P+    D        +G++F++H P+  P  F+G  L       + V ++  +  H+     +  P IK R + TY         TY      C+       +++ C C+    P  +  NG+E       C   +Y      N    I  +  +  LC            C+ + Y   I+ + +P                            S  A+K L       L Q+ +  R++L+N +  + D N+ +             ++ +   +  LL+D+GG +GL+ GASLIT+ E+ + +  S
Sbjct:   42 AISTSFHGIHNIAQNQNKVRKVIWLSVVLGSV---SLLVWQIYSRLVNYFMWPTTTSIEVQYVEKIEFPAVTFCNLNR-FQTEAVSRFGIIFFLWDIVSKVLRLQEISGNNTGSPEALDFVASHRNFSITEFVKNNGFYLNH---DTLVHCEFFGKTCDPKDFKHV-FTEYGNCFTFNYGENVQSK--NKVSVSGRGLKLLLDVHQEEFTDNPVPGFAD--------AGVIFVIHSPKKEPQ-FDGLGLSSPVGMHARVTIRQLKTIHQEYPWGECNPDIKLRNFTTY--------STY-----GCLKECKAKHIQRLCGCL----PFLLPGNGVE-------CDLLKYY-----NCVSPILDHIERKGLCTMGTHNSSCPVPCEETEYPATIAYSTFP----------------------------SQRATKFLAKK----LNQSQEYIRENLVNIEINYSDLNYKI------------TQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIEYLFTS 470
[Close]
BLAST of Acid-sensing ion channel 1 vs. UniProt/SwissProt
Match: sp|P51168|SCNNB_HUMAN (Amiloride-sensitive sodium channel subunit beta OS=Homo sapiens OX=9606 GN=SCNN1B PE=1 SV=2)

HSP 1 Score: 77.0258 bits (188), Expect = 2.333e-13
Identity = 86/370 (23.24%), Postives = 152/370 (41.08%), Query Frame = 2 
Query:  506 QFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYI-------FEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILD 1594
            + S+PG  +I  C +  + C + NFT I    YG C+ FN     MT  A   S   G     ++IL  G       ++D    +   +G+  M+HE +SYP+I         G       +VD K+ R   EP   PC    +     +  ++ + TY      C+ +  Q+ + ++CNC    YP+     G ++C +      A    +C  +   ++ + E  + +C K+ C+ + Y+  IS A +P+  E + + ++                                L Q  DQ     L++    +  + L +  Q      +EE     I  LLS++GG  G W+G S++ + E  ++I+D
Sbjct:  237 EMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFN---WGMTEKALP-SANPGTEFGLKLILDIG-------QEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVD-KLQR-MGEP-YSPCTVNGSEVPVQNFYSDYNTTY--SIQACLRSCFQDHMIRNCNCGHYLYPLP---RGEKYCNNRDFPDWA----HCYSDLQMSVAQRETCIGMC-KESCNDTQYKMTISMADWPS--EASEDWIFH------------------------------VLSQERDQSTNITLSR----KGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIID 546
[Close]
BLAST of Acid-sensing ion channel 1 vs. UniProt/SwissProt
Match: sp|Q95165|SCNNB_CANLF (Amiloride-sensitive sodium channel subunit beta OS=Canis lupus familiaris OX=9615 GN=SCNN1B PE=3 SV=2)

HSP 1 Score: 75.0998 bits (183), Expect = 8.443e-13
Identity = 86/366 (23.50%), Postives = 151/366 (41.26%), Query Frame = 2 
Query:  506 QFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIF-EGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWA--DCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILD 1594
            + S+P   LI  C +  + C++ NFT I    YG C+ FN     MT  A   S   G     ++IL  G       ++D    +T  +G   M+HE +SYP+I  EG      +   + +     E K +P  +     + V P+ N    Y   ++   CI +  Q+ + ++C+C    YP+     G  +C +      A     C  +   ++ + E  +N+C K+ C+ + Y+  IS A +P+  E + + ++                                L Q  DQ     L++  V +    L +  Q      +EE     I  LLS++GG  G W+G S++ + E  ++++D
Sbjct:  238 EMSYPAERLILACLFGAEPCSYRNFTSIFHPDYGNCYIFN---WGMTEKALP-SANPGAEFGLKLILDIG-------QEDYVPFLTSTAGARLMLHEQRSYPFIKDEGIYAMSGTETSIGVLVDRLERKGEPYSQCTVNGSDV-PVRNLYSDYNTTYSIQACIRSCFQDHMIQNCSCAHYLYPLP---RGERYCNNREFPDWAY----CYSHLRMSVAQRETCINMC-KESCNDTQYKMTISMADWPS--EASEDWIFH------------------------------VLSQERDQSTNITLSRKGVVK----LNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEILID 547
[Close]
BLAST of Acid-sensing ion channel 1 vs. UniProt/SwissProt
Match: sp|O97742|SCNNB_RABIT (Amiloride-sensitive sodium channel subunit beta OS=Oryctolagus cuniculus OX=9986 GN=SCNN1B PE=2 SV=1)

HSP 1 Score: 74.3294 bits (181), Expect = 1.550e-12
Identity = 94/389 (24.16%), Postives = 160/389 (41.13%), Query Frame = 2 
Query:  467 LASLSDFLYIQKKQFSHPGWS---LIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFE-------GYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWA--DCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAE-YIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILD 1594
            L + + F  + +++    G+S   LI  C +  + C++ NFT I    YG C+ FN     MT  A   S   G     ++IL  G       ++D    +   +G+  M+HE +SYP+I E       G       +VD K+ RK  EP   PC    +      P+ N   +Y   ++   C+++  Q ++  SC C    YP+     G E+C S      A  Y+   +  A     + E  + +C K+ C+ + Y+  IS A +P+  E + + ++                                L Q  DQ     L++    +  + L +  Q      +EE     I  LLS++GG  G W+G S++ + E  ++I+D
Sbjct:  222 LQATNIFSQVPQRELVELGYSAERLILACLFGAEPCSYRNFTSIFYPDYGNCYVFN---WGMTEKALP-SANPGTEFGLKLILDIG-------QEDYVPFLASTAGVRLMLHEQRSYPFIREEGVDAMSGTETSIGVLVD-KLQRK-GEP-YSPCTVNGSDV----PVQNLYGSYNTTYSIQACLHSCFQTQMIASCQCGHYLYPLP---RGQEYCNSRDFPDWAPCYLALRMSEA-----ERETCIRMC-KESCNDTQYKMTISMADWPS--EASEDWIFH------------------------------VLSQERDQSTNVTLSR----KGVVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFAEIIID 547
[Close]
BLAST of Acid-sensing ion channel 1 vs. TrEMBL
Match: A0A0R3SIE1 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS4705 PE=3 SV=1)

HSP 1 Score: 408.683 bits (1049), Expect = 2.916e-130
Identity = 206/492 (41.87%), Postives = 309/492 (62.80%), Query Frame = 2 
Query:  143 AQRTTVHGVNHLSQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDHEMFEFPEISFCNLNPIFVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLASLSDFLYIQKKQF-SHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSM--NMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKF-NKSDLASKAL----INNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILD 1594
            ++R+T+HG+NHL+Q +  + R+FWL I  AA +GF  N+F +IEKY+Q  VL+N  HD + F +P+++FCN+NPI+ PP  T E++ ++  I ++ K K + T    +   L+D+L++++  F  HP W  I  C+Y    C++ +F    LWPYG C+TFN   M  NMTR     + +  +RP+F++I+YK +D P E + DPH +V +PSGIL M+HEP +YP+I    ++D  + ++L++T   H  KL  C+  R + +YV+  TN S+ +L   +DC+   +Q  + ++C C M   P+   +N L FC S  L  S  +I++C  N       N V    C++D+C+H +   V+  AK+PA+ ER++   WL+ L  +EE E  ++  KSD+A  AL      N +LT++  +      LLN DFV+RNFM+LR+V  SLFMD+VEE EEYP SRLLSDIGG VGLW+GASLIT+FE  DLILD
Sbjct:   83 SRRSTMHGLNHLAQARTAQRRLFWLCISIAALVGFFFNMFFLIEKYIQVPVLTNVLHDSDNFIYPDVTFCNINPIYFPPKETAEFKRMIAAIEKFKKFKKS-THPHVHRLELADYLFVERNTFYVHPKWLTIVECQYMQTPCSYKHFDEKILWPYGACYTFNATKMLNNMTREIITRNRFNRFRPDFKIIVYKALDMPEEYRMDPHGSVNVPSGILLMIHEPGTYPHIGHSSIVDECAQIELRMTYVKHLAKLGKCVPEREHISYVNTATNESQNFLSSQSDCLDAAVQTALAENCGCQMHTMPVMYRYNNLPFCFSDSLNFS--FIESCFSNV-----SNAVDRQHCFRDVCEHFTIDRVVVHAKFPAIAERHTYQNWLRLLARLEEREKAQYRGKSDIAKLALNADFTANPNLTIKDIFASGNTSLLNLDFVNRNFMMLRIVPASLFMDRVEETEEYPFSRLLSDIGGCVGLWIGASLITLFEFADLILD 566
[Close]
BLAST of Acid-sensing ion channel 1 vs. TrEMBL
Match: A0A564Z6I1 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS12764 PE=3 SV=1)

HSP 1 Score: 408.297 bits (1048), Expect = 3.352e-130
Identity = 206/492 (41.87%), Postives = 309/492 (62.80%), Query Frame = 2 
Query:  143 AQRTTVHGVNHLSQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDHEMFEFPEISFCNLNPIFVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLASLSDFLYIQKKQF-SHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSM--NMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKF-NKSDLASKAL----INNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILD 1594
            ++R+T+HG+NHL+Q +  + R+FWL I  AA +GF  N+F +IEKY+Q  VL+N  HD + F +P+++FCN+NPI+ PP  T E++ ++  I ++ K K + T    +   L+D+L++++  F  HP W  I  C+Y    C++ +F    LWPYG C+TFN   M  NMTR     + +  +RP+F++I+YK +D P E + DPH +V +PSGIL M+HEP +YP+I    ++D  + ++L++T   H  KL  C+  R + +YV+  TN S+ +L   +DC+   +Q  + ++C C M   P+   +N L FC S  L  S  +I++C  N       N V    C++D+C+H +   V+  AK+PA+ ER++   WL+ L  +EE E  ++  KSD+A  AL      N +LT++  +      LLN DFV+RNFM+LR+V  SLFMD+VEE EEYP SRLLSDIGG VGLW+GASLIT+FE  DLILD
Sbjct:   83 SRRSTMHGLNHLAQARTAQRRLFWLCISIAALVGFFFNMFFLIEKYIQVPVLTNVLHDSDNFIYPDVTFCNINPIYFPPKETAEFKRMIAAIEKFKKFKKS-THPHVHRLELADYLFVERNTFYVHPKWLTIVECQYMQTPCSYKHFDEKILWPYGACYTFNATKMLNNMTREIITRNRFNRFRPDFKIIVYKALDMPEEYRMDPHGSVNVPSGILLMIHEPGTYPHIGHSSIVDECAQIELRMTYVKHLAKLGKCVPEREHISYVNTATNESQNFLSSQSDCLDAAVQTALAENCGCQMHTMPVMYRYNNLPFCFSDSLNFS--FIESCFSNV-----SNAVDRQHCFRDVCEHFTIDRVVVHAKFPAIAERHTYQNWLRLLARLEEREKAQYRGKSDIAKLALNADFTANPNLTIKDIFASGNTSLLNLDFVNRNFMMLRIVPASLFMDRVEETEEYPFSRLLSDIGGCVGLWIGASLITLFEFADLILD 566
[Close]
BLAST of Acid-sensing ion channel 1 vs. TrEMBL
Match: A0A0R3TJX9 (Uncharacterized protein OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS7422 PE=3 SV=1)

HSP 1 Score: 392.119 bits (1006), Expect = 7.878e-124
Identity = 203/496 (40.93%), Postives = 309/496 (62.30%), Query Frame = 2 
Query:  143 AQRTTVHGVNHLSQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDHEMFEFPEISFCNLNPIFVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLASLSDFLYIQKKQF-SHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSM--NMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKF-NKSDLASKAL----INNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAEI 1606
            ++R+T+HG+NHLSQ +  + R+FWL I  AA  GF  N+F ++EKY+Q  VL+N  HD + F +P+++FC +NPI+ PP GT E++ +   I ++ + K +       L  L+D+L++++  +  HP W  I  C+Y    C++ +F    LWPYG C+TFN   M  NMTR     + +  +RP+F++I+YK +D P + + DPH +V +PSG+L M+HEP +YP+I    ++D  + ++L++T   H  KL  C+  R Y +YV+  TN S+ +L    DC+   +Q  + ++C C M   P+  +++ L FC S  L  +  +I+NC  N       N V    C++D+C+H +   V++ AK+PA+EER++   WL  L  +EE E  ++  KSD+A  AL      N +LT+++        LLN DFV+RNFM+LR+V  SLFMD+VEE EEYP SRLLSDIGG VGLW+GASLIT+FE  DLILD  ++
Sbjct:   85 SRRSTMHGLNHLSQARTAQRRLFWLCISIAALFGFFFNMFFLVEKYVQVPVLTNVLHDSDNFIYPDVTFCTINPIYFPPEGTTEFERMSSAIEKFKEFKRSNHPHVHRL-ELADYLFVERNTYYVHPKWLTIVECQYMQTPCSYKHFDEKILWPYGACYTFNATKMLNNMTREIITRNRFNRFRPDFKIIVYKALDMPEKFRMDPHGSVNVPSGVLLMIHEPGTYPHIGHSSIVDECTQIELRMTYVKHLAKLGKCVPEREYISYVNTATNKSQIFLSSQPDCLDAAVQTALAENCGCQMHTMPVMYKYHHLPFCFSDAL--NFTFIENCFSNV-----ANTVDRKHCFRDVCEHFTIDRVVAHAKFPAIEERHTYYNWLHLLARLEEREEAQYKGKSDIAKLALNADFTVNPNLTIKEVLVSGNTSLLNLDFVNRNFMMLRIVPASLFMDRVEETEEYPFSRLLSDIGGCVGLWIGASLITLFEFADLILDCVDL 572
[Close]
BLAST of Acid-sensing ion channel 1 vs. TrEMBL
Match: A0A3P7LUS4 (Uncharacterized protein OS=Dibothriocephalus latus OX=60516 GN=DILT_LOCUS5772 PE=3 SV=1)

HSP 1 Score: 384.8 bits (987), Expect = 2.589e-121
Identity = 208/486 (42.80%), Postives = 302/486 (62.14%), Query Frame = 2 
Query:  143 AQRTTVHGVNHLSQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDHEMFEFPEISFCNLNPIFVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLASLSDFLYIQKKQF-SHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSM--NMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKF-NKSDLASKALINNS-----SLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFE 1573
            ++R+T+HG+NHL+Q +  + R+FWL I  A++ GF  NLF ++EKYLQ  VL+N  HD + F FP+++FCN+NPI  PP+GT E++ +   I E+   K      +  LA L+D+L+I++  +  HP W  I  C Y    C+  +F    +WPYG C+TFN   M  NMTR     + Y  +RP+  VI+YK ++FP   + DPH +  +P G+L M+HEP +YP+I    ++D  + V+LK+T   H  KL  CI  R+  +YV+   N S+T+L   +DC+   +Q+ + K C C M   PI  E++   FC S  L     +++NC  NA  ++ +       C+ D+C+H +   VI+  K+PA+E+R++E+ WL+ L  +E  E   +  KSDLA  AL N S     + TL +A +Q + DLLN DFV+RNFM+LRVV  SLFMD+VEE EEYP SRLLSDIGG VGLW+GASLIT+FE
Sbjct:   77 SRRSTMHGLNHLAQARTAQRRLFWLCISLASSFGFFFNLFFLMEKYLQMPVLTNVLHDSDNFIFPDVTFCNVNPIHFPPNGTPEFERIKENIREFEDFKRGPNPFAQRLA-LADYLFIKRNTYYVHPKWLTIVECSYMQTPCSSEHFDEKIIWPYGACYTFNATRMPHNMTREISTRTRYNRFRPDLRVIVYKALEFPEGYRFDPHDSFQVPPGVLLMIHEPGTYPHIGHSGIVDECTQVELKMTSVTHLAKLGKCIPIRSRISYVNVAKNESQTFLSSQSDCLDAEVQSALAKYCGCQMHTMPIMYEYHYQPFCFSGAL--DPTFLENCFNNATASVDRKH-----CFLDVCEHYTIDQVIAHTKFPAIEDRHTELHWLQLLARLEARERNHYGGKSDLAKLALKNASRDGGGNWTLAEAVNQRQIDLLNIDFVNRNFMMLRVVPASLFMDRVEETEEYPFSRLLSDIGGCVGLWIGASLITLFE 554
[Close]
BLAST of Acid-sensing ion channel 1 vs. TrEMBL
Match: A0A183SCX1 (Uncharacterized protein OS=Schistocephalus solidus OX=70667 GN=SSLN_LOCUS2069 PE=3 SV=1)

HSP 1 Score: 379.407 bits (973), Expect = 1.671e-120
Identity = 200/484 (41.32%), Postives = 306/484 (63.22%), Query Frame = 2 
Query:  143 AQRTTVHGVNHLSQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDHEMFEFPEISFCNLNPIFVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLASLSDFLYIQKKQF-SHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSM--NMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFN-KSDLASKAL--INNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFEL 1576
            ++R+T+HG+NHL+Q +  + R+FWL I  A++ GF  NLF ++EKY+Q  VL+N  HD + F FP+++FCN+NPI+ PP+GT E++ +   I  +   K +    +  LA L+D+L+I++  +  HP W  I  C Y    C+  +F    +WPYG C+TFN   M  NM+R     + Y  +RP+  +I+YK ++FP   + DPH +  +P G+L M+HEP +YP+I    ++D  + V+LK+T   H  KL  CI  R+   YV+  +N S+T+L   +DC+   +Q+ + K C C M   PI  E++   FC S  L     +++ C   A  ++ +       C+ D+C+H +   VI+  K+PAVE+R++E  WL+ L ++E+ E+++++ +SDLA  AL  +   ++TL +A  + + DLLN DFV+RNFM+LRVV  SLFMD+VEE EEYP SRLLSDIGG VGLW+GASLIT+FEL
Sbjct:   81 SRRSTMHGLNHLAQARTAQRRLFWLCISLASSFGFFFNLFFLMEKYIQVPVLTNVLHDSDNFIFPDVTFCNVNPIYFPPNGTPEFERIKENIHAFEDFKRSSNPFAKRLA-LADYLFIKRNTYYVHPKWLTIVECSYMQTPCSSEHFDEKIIWPYGACYTFNATRMPHNMSREISTRTRYNRFRPDLRIIVYKALEFPEGYRFDPHDSFQVPPGVLLMIHEPGTYPHIGHSGIVDECTQVELKMTSVTHLAKLGKCIPMRSRIAYVNVASNESQTFLSSQSDCLDAEVQSALAKYCGCQMHTMPIMYEYHHQPFCFSGAL--EPSFLETCFNKATASVDRKH-----CFLDVCEHYTIDRVIAHTKFPAVEDRHTEQHWLQLLADLEDRELKQYSGRSDLAKMALKDVPGGNITLAEAAKKRQIDLLNIDFVNRNFMMLRVVPDSLFMDRVEETEEYPFSRLLSDIGGCVGLWIGASLITLFEL 556
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Cavefish
Match: asic4a (acid-sensing ion channel 4 [Source:NCBI gene;Acc:103040152])

HSP 1 Score: 57.3806 bits (137), Expect = 3.350e-8
Identity = 25/66 (37.88%), Postives = 46/66 (69.70%), Query Frame = 2 
Query: 1391 RKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLI 1588
            RK   ++D++  NF++L +  ++L  + +E+ + Y ++ LL DIGG +GL++GAS++TV E+ D I
Sbjct:  397 RKYHKSEDYIRDNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASILTVLEILDYI 462
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Cavefish
Match: asic4b (acid-sensing ion channel 4 [Source:NCBI gene;Acc:103044180])

HSP 1 Score: 57.3806 bits (137), Expect = 3.654e-8
Identity = 25/66 (37.88%), Postives = 45/66 (68.18%), Query Frame = 2 
Query: 1391 RKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLI 1588
            RK    +D++  NF++L +  ++L  + +E+ + Y I+ LL DIGG +GL++GAS++T+ E+ D I
Sbjct:  401 RKYHTTEDYIRDNFLILDIYFEALNYETIEQKKAYDIAGLLGDIGGQMGLFIGASILTILEILDYI 466
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Cavefish
Match: asic2 (acid-sensing (proton-gated) ion channel 2 [Source:NCBI gene;Acc:407669])

HSP 1 Score: 54.299 bits (129), Expect = 1.467e-7
Identity = 45/192 (23.44%), Postives = 79/192 (41.15%), Query Frame = 2 
Query: 1007 VKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFD 1582
            + ++CNC M   P             S  C   +Y K+C   A  A+   E    +C ++ C+ + Y   +S  K P+                      +KFN+S+                             ++  N ++L V  ++L  + +E+ + Y ++ LL DIGG +GL++GAS++T+ ELFD
Sbjct:  109 IVENCNCRMVHMP-----------GDSPYCTPEQY-KDCAEPALAALSAVEGSNCVC-RNPCNMTRYNKELSMVKIPS--------------KTSARYLEKKFNRSE----------------------------KYITDNILVLDVFFEALNYETIEQKKAYEVAGLLGDIGGQMGLFIGASILTILELFD 245
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Cavefish
Match: asic4a (acid-sensing ion channel 4 [Source:NCBI gene;Acc:103040152])

HSP 1 Score: 54.6842 bits (130), Expect = 2.170e-7
Identity = 26/72 (36.11%), Postives = 48/72 (66.67%), Query Frame = 2 
Query: 1391 RKDLLNKDFVD-RNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAE 1603
            RK   ++D++   NF++L +  ++L  + +E+ + Y ++ LL DIGG +GL++GAS++TV E+ D I +  E
Sbjct:  379 RKYHKSEDYIRYHNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASILTVLEILDYIYEVKE 450
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Cavefish
Match: asic1c (acid-sensing ion channel 1C-like [Source:NCBI gene;Acc:103034544])

HSP 1 Score: 54.299 bits (129), Expect = 3.159e-7
Identity = 42/192 (21.88%), Postives = 82/192 (42.71%), Query Frame = 2 
Query: 1013 KSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLI 1588
            ++CNC M   P            +S +C   +Y K+C   A   + + +    +C +  C+ + Y   +S  K P+                  +   +KFNK++                             ++  N ++L +  ++L  +K+E+ + Y ++ LL DIGG +GL++GAS++T+ E+FD +
Sbjct:  321 ENCNCRMVHMP-----------GTSTVCTPEQY-KDCADPALDFLVEKDNDYCVC-QTPCNMTRYGKELSMVKIPS--------------KASAKYLAKKFNKTE----------------------------QYIGDNILVLDIFFEALNYEKIEQKKAYEVAGLLGDIGGQMGLFIGASVLTILEIFDYL 457
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Sea Lamprey
Match: asic1a (acid-sensing (proton-gated) ion channel 1a [Source:NCBI gene;Acc:791696])

HSP 1 Score: 76.6406 bits (187), Expect = 6.823e-15
Identity = 112/519 (21.58%), Postives = 198/519 (38.15%), Query Frame = 2 
Query:  107 ADPKTYADSSFNAQRTTVHGVNHL-SQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVLSN-TYHDHEMFEFPEISFCNLNPIF---VPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLASLSDFLYIQKKQF----SHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVI---LYKGIDFPLEMKQDPH-------HTVTMPSGILFMMHEPQSYPYIFE---GYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPI-TNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDL-CDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQS-LFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLI 1588
              P+  A + F A  +T+HG+NH+ +  +    R  W     A+   F       I  YL++  ++     +  +  FP I+ CN N      V P   K Y   +  I +     N+  LA+  +  L  +      +F     H    ++  CRY+ + C   NFT +    YG C+ FN                +G RP    +      G++  L+++QD +         +++ +G+   +H     P++ +   G    F + V  +  R  + P      K        DPI ++   TY      C  +     V ++CNC M   P    +           C   +Y K C   A    F  E   N C  D  C+ + Y   +S  K P+                  +   +K+NK++                            D++  N ++L +  ++ L  + +E+ + Y ++ LL DIGG +GL++GAS++T+ E+FD +
Sbjct:   41 GQPQASAITEF-ASESTLHGINHIFAPGEFSLRRAIWACAFLASLGMFLYQSADRIVFYLEHHHVTQLDEQESHLMLFPAITLCNFNSFRRSKVTPV-DKHYAGPILGIPD-----NDPDLATVDVRLLRAWSRYSTYEFYDRAGHTMDEMLLRCRYRDRECGPTNFTTV-FTRYGKCYMFNSG--------------KGGRPLLTTLKGGTGNGLEMMLDIQQDEYLPVWGETDEISLEAGVKVQIHSQDEPPFVHQLGFGVAPGFQTFVSCQEQRLIYLPSPWGDCK-------ADPINSDFFDTY--SITACRIDCETRYVVENCNCRMVHMPGDAPY-----------CTPEQY-KECADPALD--FLVEKDNNYCVCDTPCNTTRYGKELSMVKIPS--------------KASAKYLAKKYNKTE----------------------------DYIRENVLVLDIFFEAALNYETIEQKKAYEVAGLLGDIGGQMGLFIGASILTILEIFDYL 472
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Sea Lamprey
Match: SCNN1B (sodium channel epithelial 1 beta subunit [Source:HGNC Symbol;Acc:HGNC:10600])

HSP 1 Score: 53.9138 bits (128), Expect = 7.821e-8
Identity = 71/364 (19.51%), Postives = 136/364 (37.36%), Query Frame = 2 
Query:  497 QKKQFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHT-VTMPSGILFMMHEPQSYPYIFEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVD--------PITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLI 1561
            +K   S  G  LI  C + +  C+  NFT      YG CF FN          +  ++ +   P  E     G+   L + QD +   +T  +G + M+H+  +YP++ +   L  F    ++ +      +L+     R    Y D        PITN           C+ +  Q ++ + C C    YP+     G ++C++          + C    ++   + ++      K  C  S Y+  IS + +P+  + + + ++     E +    R FN+                       ++D++  +   + F  +           + E     I  LLS++GG  G W+G S++
Sbjct:  238 EKSNLSSSGDELIRSCLFSSDTCSATNFTTFFHPMYGNCFIFN--------WGENETVMQVSNPGVEY----GLKLVLSIDQDEYIPFLTTIAGAVIMVHDQNTYPFLSD---LGVFVKTGVETSVGIEVGQLQ-----RQGAPYSDCTMDGTDLPITNLYNGTAYSVQACLRSCFQTKMIEMCGCGYYLYPLP---PGEKYCQNQNFTG----WRYCYYKLYEQFVEEDMDCYTICKQPCIESEYKMSISMSDWPS--QSSEDWIFHILSKERKHNVSRIFNR-----------------------KQDIIKLNLFFQEFNSM----------TISESPAQTIVTLLSNLGGQFGFWMGGSVL 539
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Sea Lamprey
Match: asic1b (acid-sensing (proton-gated) ion channel 1b [Source:NCBI gene;Acc:407672])

HSP 1 Score: 47.7506 bits (112), Expect = 6.604e-6
Identity = 30/100 (30.00%), Postives = 57/100 (57.00%), Query Frame = 2 
Query: 1406 NKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLL--SDIGGIVGLWLGASLITVFELFDLI--LDSAEILYNNPYYQYKKMS------TGVSKKSRNH 1675
             + ++  N ++L +  ++L  + +E+ + Y ++ LL   DIGG +GL++GAS++T+ E+FD +  L   +IL+   Y++ KK        TG  +  R H
Sbjct:  401 TEAYIAENVLVLDIFFEALNYETIEQKKAYEVAGLLETGDIGGQMGLFIGASILTILEIFDYVYELIRDKILF---YFRAKKKQKTESKDTGPCEALRGH 497
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Nematostella
Match: EDO39413 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SA77])

HSP 1 Score: 73.9442 bits (180), Expect = 7.374e-14
Identity = 114/520 (21.92%), Postives = 200/520 (38.46%), Query Frame = 2 
Query:  125 ADSSFN------AQRTTVHGVNHLSQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVL-SNTYHDHEMFEFPEISFCNLNPI----FVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLASLSDFLYIQKKQFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSY--PYIFEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGL-----EFCKSSMLCHSAEY-IKNCLGNAFKAIFKNE-----VKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQH-------RKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLIL 1591
            ADS+ N      A  TT+HG++ L Q   +  +I W +++  A +G +I +   + K   Y +  + T+   E   FP I+ CN N +     +  +G +    L    A +     N T     + ++     +QK    H    ++  CR+    C   +    T    G C+TFN + +N T +                + + G ++ L ++ D                EP  Y  PY ++G           KI    H+ K+ P I+   Y   + P         G +        Q + K+SC  V+  Y I+ +   L       C S  L  S EY  KNC+      +         + M L   D   + + + V  Q     V ER+S       +         + + +   S+ +       L  AYD +         D+  + FV + F ++++  ++L  +   +   Y +S L +D+GG +GL+LG S++T+ E  DL +
Sbjct:   41 ADSAKNTLIGNFASYTTLHGLHFLFQPIPRARKIIWGIMLVIATVGLSIQIGNGLVKVYSYNIFTAKTFVRPESLPFPAITICNQNMLRKTAILGSAGQRYLDQLDELRARFIGEDMNVTSERINMDAI-----VQKS--GHQLEKMVYECRFVRDKCDNKSIKVFTSEKRGLCYTFN-SGVNGTPLLN--------------VSHSGSEYSLSLRLDA---------------EPTEYYGPYSYDG--------TGFKIA--VHDQKVLPDIEEDAY--DISP---------GFYTKITMKRAQKQTKQSCTDVVTAYVINSQTLFLPSPYSSGCGSRKLQFSQEYSYKNCIRECHTQLMIGRCRCRAIGMTLQENDTTPYCTTREV--QDCIMRVHERSSRQRCDCPVPCEMTTFTSRISLAYFPSQHVWETFLPFLTTAYDLNLTGLSPDELDMKAEHFVRKRFAMVKIFYETLRTEMYHQRPAYEMSDLFADVGGNMGLFLGCSMLTIAEFIDLAI 500
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Nematostella
Match: EDO36191 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJB5])

HSP 1 Score: 57.3806 bits (137), Expect = 9.505e-9
Identity = 77/378 (20.37%), Postives = 136/378 (35.98%), Query Frame = 2 
Query:  530 LIAHCRYQTKVCTWINF----TPITLWPYGTCFTFNPN-SMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHT-VTMPSGILFMMHEPQSYPYIFEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAEILYNNPYYQYKKMS 1645
            L+  C +   VC   +F     P   W YG C+TFN    +N T +    S   G  P +      G+   L + Q+ +   ++  +G+  ++ + ++ P+ F                               T+   V P  + S    G    C+ + + N   K CNC   ++   ++                     CL N  K      +  +      C H S++  ISQ ++    E+  +               R   KSD      +N++S+                  + +NF+ +++  + L  + +     YP+  LL D+GG +GLW+G S+IT  E   L++D A       +Y   KMS
Sbjct:  189 LVFRCVWNGFVCNKGDFLKYWRPFWHWRYGNCYTFNQGVDVNGTELPSLASSKPG--PMY------GLTLDLFIDQEQYIIPLSQEAGVKVLLSDQRNIPFPF-------------------------------THGFTVQPGVSASA---GIRQGCMSSCLANNQFKVCNCTEGKFRAKVK---------------------CLNNISKKYENGSLGCSKSCPQPCTHYSFRRTISQTQWSDSYEKTFQ---------------RLVRKSDRGFANKMNDASI------------------LRKNFLRVKLYYEELNRETITYSLSYPVENLLGDVGGQLGLWIGVSVITCAEFLKLLVDLA-------WYLASKMS 463
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Nematostella
Match: EDO30892 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZH3])

HSP 1 Score: 56.6102 bits (135), Expect = 1.252e-8
Identity = 54/251 (21.51%), Postives = 104/251 (41.43%), Query Frame = 2 
Query:  152 TTVHGVNHLSQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQY-QVLSNTYHDHEMFEFPEISFCNLNPI-----------FVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLASL--SDFLYIQKKQFSHPGWSLIAH-------------CRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHT--VTMPSGILFMMHEPQSYPYI 817
            T++HGV +L++    R R+ WL++V AA  GF   L++ I  Y ++  V + T    E  +FP ++ CNLN +           +   + T++ +  +     +     N+   S  L     +   Y ++  F +   +  +H             C++  + C   NF+      +G C TFN       +    L +     PN       G+   L ++Q+ H +    +P+G   ++H+ + YP +
Sbjct:   13 TSLHGVRYLTENSFIR-RVIWLLVVLAAFCGFGYQLYKSITFYYEWPTVTAMTTEWDEELDFPAVTICNLNTLSKENFVKARKRYKSDATTEQLEKEVETFTFFMSAPLNENAKSKLLNDFFENSTFYRERGNFVNKSLNDFSHSIDGILSIKWLRPCQFSGEDCDRKNFSSFVDLNFGLCHTFNSGK----KEENALKV-ESLGPN------NGLRLRLNVQQEDHVSNFYWLPAGFKVLVHDRKEYPIM 251
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Nematostella
Match: EDO48656 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI82])

HSP 1 Score: 55.4546 bits (132), Expect = 5.599e-8
Identity = 28/80 (35.00%), Postives = 46/80 (57.50%), Query Frame = 2 
Query: 1349 NNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLI 1588
            NN +  L + Y     D  N+ ++  N + +++  + L    V++V  Y +  LL D+GG +GL+LGASL+TV E  DL+
Sbjct:  493 NNYAKMLAKEYGLKGSDEENRQYLRDNLIEIKIYYEDLTYFDVQQVPSYDLYSLLGDVGGQIGLFLGASLLTVVEYLDLL 572
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Nematostella
Match: EDO48658 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI84])

HSP 1 Score: 52.373 bits (124), Expect = 1.714e-7
Identity = 22/60 (36.67%), Postives = 39/60 (65.00%), Query Frame = 2 
Query: 1412 DFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLIL 1591
            DF+  N+ ++ +    L +D +++   Y   RL+ D+GG +GL LGAS+IT+ E+ DL++
Sbjct:  153 DFILENYSVINLFFDELRLDTIQQTPAYGFFRLVGDVGGQLGLVLGASVITIVEIIDLVI 212
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Medaka
Match: ENSORLT00000015581.2 (acid-sensing ion channel 1C [Source:NCBI gene;Acc:101174951])

HSP 1 Score: 85.1149 bits (209), Expect = 6.173e-17
Identity = 111/519 (21.39%), Postives = 210/519 (40.46%), Query Frame = 2 
Query:  110 DPKTYADSSFNAQRTTVHGVNHLSQVKNQR-GRIFWLMIVSAAALGFTINLFQIIEKYLQY-QVLSNTYHDHEMFEFPEISFCNLNPIFVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLASLS----DFLYIQKKQF---------SHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTV-------TMPSGILFMMHEPQSYPYIFE---GYLLDFFSVVDLKITR-KFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLI 1588
            +P+  +D +      T+HG++H+         R+ W    S++   F + +   + +Y QY  V      D  +  FP I+FCN N        ++  +N + W+A+   V+  Q     ++A+L     D  +   K F         SH    ++  C+Y+ + C   NFT I    YG C+TFN + ++   +   L+  +G   N       G++  L+++QD +  V       +  +GI   +H     P+I +   G    F + V  +    ++  P    C  T     +    + T+         C  +     + ++CNC M   P            +S +C   +Y K+C   A   + + +    +C +  C+ + Y   +S  K P+                  +   +KFNK++                             ++  N ++L +  ++L  +K+E+ + Y I+ LL DIGG +GL++GAS++T+ E+FD +
Sbjct:    8 EPRPPSDITVFGANCTLHGLSHIFLPGGVTFRRLLWAAAFSSSLSIFLLQVADRVIEYFQYPHVTILDEMDSPVMFFPAITFCNYNSF----RKSQITRNDIFWMAKMLGVE--QGDFDDFMAALGKPSDDSKFFPSKTFNMLEFVQRSSHSIEEMLLDCKYRGQDCGPENFTTIYTR-YGKCYTFN-SGLDGNPL---LTTLKGGTGN-------GLEIMLDIQQDEYLPVWGETDETSYEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQQQLLQYLPPPWGDCKSTPIDSEFFSTYSITA---------CRIDCETRYLLENCNCRMVHMP-----------GTSTVCTPDQY-KDCADPALDFLVEKDNNYCVC-ETPCNMTRYGKELSMVKIPS--------------KASAKYLAKKFNKTE----------------------------QYIGDNILVLDIFFEALNYEKIEQKKAYEIAGLLGDIGGQMGLFIGASVLTILEIFDYL 444
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Medaka
Match: asic4a (acid sensing ion channel subunit family member 4 [Source:NCBI gene;Acc:101159336])

HSP 1 Score: 56.9954 bits (136), Expect = 4.474e-8
Identity = 26/81 (32.10%), Postives = 52/81 (64.20%), Query Frame = 2 
Query: 1352 NSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILD 1594
             S+  L + YD+      ++D++  NF++L +  ++L  + +E+ + Y ++ LL DIGG +GL++GAS++TV E+ D + +
Sbjct:  387 GSARYLSRKYDK------SEDYIRDNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASILTVLEILDYVFE 461
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Medaka
Match: ENSORLT00000035361.1 (acid-sensing ion channel 1C [Source:NCBI gene;Acc:101174951])

HSP 1 Score: 54.299 bits (129), Expect = 2.684e-7
Identity = 22/63 (34.92%), Postives = 44/63 (69.84%), Query Frame = 2 
Query: 1406 NKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILD 1594
             + ++  N ++L +  ++L  +K+E+ + Y I+ LL DIGG +GL++GAS++T+ E+FD + +
Sbjct:  418 TEQYIGDNILVLDIFFEALNYEKIEQKKAYEIAGLLGDIGGQMGLFIGASVLTILEIFDYLYE 480
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Medaka
Match: ENSORLT00000021925.2 (acid-sensing ion channel 1C [Source:NCBI gene;Acc:101174951])

HSP 1 Score: 54.299 bits (129), Expect = 2.687e-7
Identity = 22/60 (36.67%), Postives = 43/60 (71.67%), Query Frame = 2 
Query: 1409 KDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLI 1588
            + ++  N ++L +  ++L  +K+E+ + Y I+ LL DIGG +GL++GAS++T+ E+FD +
Sbjct:  395 EQYIGDNILVLDIFFEALNYEKIEQKKAYEIAGLLGDIGGQMGLFIGASVLTILEIFDYL 454
[Close]
BLAST of Acid-sensing ion channel 1 vs. Ensembl Medaka
Match: ENSORLT00000021936.2 (acid-sensing ion channel 1C [Source:NCBI gene;Acc:101174951])

HSP 1 Score: 54.299 bits (129), Expect = 2.871e-7
Identity = 22/61 (36.07%), Postives = 43/61 (70.49%), Query Frame = 2 
Query: 1406 NKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLI 1588
             + ++  N ++L +  ++L  +K+E+ + Y I+ LL DIGG +GL++GAS++T+ E+FD +
Sbjct:  418 TEQYIGDNILVLDIFFEALNYEKIEQKKAYEIAGLLGDIGGQMGLFIGASVLTILEIFDYL 478
[Close]
BLAST of Acid-sensing ion channel 1 vs. Planmine SMEST
Match: SMESG000016710.1 (SMESG000016710.1)

HSP 1 Score: 1117.84 bits (2890), Expect = 0.000e+0
Identity = 563/563 (100.00%), Postives = 563/563 (100.00%), Query Frame = 2 
Query:  218 MIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDHEMFEFPEISFCNLNPIFVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLASLSDFLYIQKKQFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAEILYNNPYYQYKKMSTGVSKKSRNHLLYRSNTKYDEIVKLNSNIVTINKWKDDVCCSSPPDNRIFGDXXXXXXXXXXXXEDLTKLRPRSKSLKDDYNIVSTV 1906
            MIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDHEMFEFPEISFCNLNPIFVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLASLSDFLYIQKKQFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWLKKLTEMEELEMRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAEILYNNPYYQYKKMSTGVSKKSRNHLLYRSNTKYDEIVKLNSNIVTINKWKDDVCCSSPPDNRIFGDNNCINTSNSLNNEDLTKLRPRSKSLKDDYNIVSTV
Sbjct:    1 MIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDHEMFEFPEISFCNLNPIFVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLASLSDFLYIQKKQFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWLKKLTEMEELEMRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAEILYNNPYYQYKKMSTGVSKKSRNHLLYRSNTKYDEIVKLNSNIVTINKWKDDVCCSSPPDNRIFGDNNCINTSNSLNNEDLTKLRPRSKSLKDDYNIVSTV 563
[Close]
BLAST of Acid-sensing ion channel 1 vs. Planmine SMEST
Match: SMESG000047581.1 (SMESG000047581.1)

HSP 1 Score: 450.284 bits (1157), Expect = 3.394e-150
Identity = 231/523 (44.17%), Postives = 343/523 (65.58%), Query Frame = 2 
Query:  143 AQRTTVHGVNHLSQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDHEMFEFPEISFCNLNPIFVPPSGTKEYQNLLRWIAEYPKVKNN--QTLASSYLASL-----SDFLYIQKK-QFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNM--TRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALI-NNSSL-----TLRQAYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAEILYNNPYYQYKKMSTGVSKK 1663
            ++R+T+HG+NHL+Q ++ + R+FWL I  +A+LGF +NLF +IEK+LQ  VL+N +HD   F +P++S C +NPI+ PP  T+    L+  I EY ++ N+      SSY A+L     SD+L++  K ++SHP WS I  CRY  K C + +F    +WPYG CFTFN   M +  TR  +K ++  G+RP+F++++YK +++P+ ++ DP + +  PSG+L M+HEP +YP+I E +++D F+ VDLKIT K H   LK C   R  YTY D  TNTS  ++GR  DC+++IIQ  +   C C + + PI  +   L FC         E +  CL  +   + + +++  LCYKDLC+H S+ TV+S +KYPAV ER + M+WL+ L ++E LE+  + +S+L + A++ +NSSL     ++R+ YD+ R DLLN+ F+++NFM LR V  SLFMD VEE EEYP+SRLLSDIGG VGLW+GASLITVFE  DL+LD +EI+      +Y+  +T V K+
Sbjct:   61 SRRSTIHGLNHLAQARSAKHRLFWLTISCSASLGFCVNLFYLIEKFLQTPVLTNVFHDFNNFTYPDLSICIVNPIYFPPENTRYRNELISTIEEYYRLTNSSFHDSKSSYNANLQKIELSDYLFMHSKLEYSHPSWSAIILCRYLKKKCNYTHFETRHIWPYGNCFTFNGTKMGLEGTRDVKKNTVLNGWRPDFKLVIYKALEYPVNLQIDPFNDINKPSGVLVMIHEPNTYPHIGESFVVDSFTQVDLKITTKSHLSSLKKCESIRNNYTYYDFKTNTSNIFVGRQGDCLFSIIQTNIANYCGCQLHKMPILEKHKQLPFCYDKRF--RNENLTYCLHASLDDVDREQLRQ-LCYKDLCEHPSFSTVVSHSKYPAVRERQTHMLWLEHLKDLELLEIEHYGQSELINMAILKSNSSLKHNYKSIREIYDKGRIDLLNEKFINKNFMHLRFVPSSLFMDHVEETEEYPLSRLLSDIGGCVGLWVGASLITVFEFIDLLLDLSEII------RYRSQATVVYKQ 574
[Close]
BLAST of Acid-sensing ion channel 1 vs. Planmine SMEST
Match: SMESG000009914.1 (SMESG000009914.1)

HSP 1 Score: 419.468 bits (1077), Expect = 2.222e-138
Identity = 220/534 (41.20%), Postives = 327/534 (61.24%), Query Frame = 2 
Query:  143 AQRTTVHGVNHLSQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDHEMFEFPEISFCNLNPIFVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLAS-----------LSDFLYIQKK-QFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSM--NMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCH--SAEYIKNCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINNSSLTLRQ-------------------AYDQHRKDLLNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAEILYNNPYYQYKK 1639
             +R+T+HG+NHL+Q ++ + R+FWL I + A +GF +NLF ++EK++Q  +L+NT+HD+  F +P+I+FC +NPI  PP  + +Y+ L+  I  Y  ++N ++L   Y+ S           L D+L+I++   +SH  WS I  CRY    C+W +F    +WPYG CFTFN   M  N+TR  Q+     G+RP+F +I+YK I+    +  DP + +T PSG+L M+HE ++YP++ + +++D ++ VDLKIT K H   LK C   R  YTY D  +   +T+ GR  DC++ IIQN++ K+C C M   P+ M+     FC S ML +  +   I+ CL      + K  +  ++CY+DLC H SY TVIS +KYPA+++R +  +WLKKL  +E+ E+  +  S+L  KA+  N S  LR                     Y   R DL+++ F+D+NFM LR V  SLFMD +EE EEYPISRLLSDIGG VGLW+GASLIT+FE FDL++D ++IL   P+   +K
Sbjct:   40 TRRSTIHGLNHLAQARSAKRRLFWLFISTCATVGFFVNLFYLVEKFIQTPILTNTFHDYTSFIYPDITFCLVNPINFPPKTSAQYKYLIGIINNY--IRNEESLFHKYINSSKNEDFLPKLELMDYLFIKENISYSHSPWSAIVDCRYLHYPCSWEHFDVHFVWPYGNCFTFNATKMQKNLTRDVQRNMQLNGFRPDFRIIIYKSINRLSSVVHDPFNDITKPSGVLVMIHEIETYPHVSDSFIVDSYTQVDLKITTKSHLESLKKCNPNRQNYTYCDYRSKKCQTFQGRNIDCVFEIIQNKIAKNCKCQMHTMPVLMKNRFYPFCYSLMLSNPLNVSSIRKCLNQTIVGVDKQSIH-SICYQDLCSHPSYSTVISHSKYPAIQDRQTHSLWLKKLIVIEKREIENYGISNLFQKAIKRNHSTLLRNPNFMENQIPIGKRFDSIDAVYRDMRDDLIDELFIDQNFMQLRFVPSSLFMDHIEETEEYPISRLLSDIGGCVGLWVGASLITIFEFFDLLMDLSDILRIRPFPNSRK 570
[Close]
BLAST of Acid-sensing ion channel 1 vs. Planmine SMEST
Match: SMESG000056126.1 (SMESG000056126.1)

HSP 1 Score: 389.423 bits (999), Expect = 4.974e-127
Identity = 217/540 (40.19%), Postives = 320/540 (59.26%), Query Frame = 2 
Query:  143 AQRTTVHGVNHLSQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDHEMFEFPEISFCNLNPIFVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLA-------------SLSDFLYIQKK-QFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKN-------CLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINN-------SSLTLRQAYDQHRKDL--LNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAEILYNNPYYQYKKMSTGVSKKSRN 1672
            ++++T+H ++HL+Q +N + R+FW +I  +A++GF INL  IIEKY +  VL+N YHD+  F FP+ISFC +NPI  PP GT++Y+ L    A Y K +N+  L +   A              LSD+L+IQ +  + HP WS I  C Y    C W +F    +WPYG CFTF    +N +R   K  I   +RP+F++I+YKG+    +   DP + +  PSG+L M+HE  +YPY  EG+++D ++ +DLKIT K H      C   R  Y Y D  T  S  + GR  DC++++IQ ++   C C+++  P+S +F  L FC   +     E I N       C+ ++F  + +  +    C++DLC H S+ TV+S +KYPAV+ER ++ +WL+KL E+E+L+MR +N SDL  KAL  N       SSL+         K++  L + FVDRNFM +RVV  SLFMD +EE  EY +SRLL DIGG +GLW+GASLITVFE  DLI    ++L +   Y+++ +     +KS+N
Sbjct:   43 SRQSTIHSLSHLAQARNIKQRMFWTIIALSASIGFLINLVNIIEKYYERPVLTNVYHDYRTFVFPDISFCLVNPIHFPPVGTRQYKQLEHQFAMYFKFRNSTHLKARQEALSFMMYKNYSLDIDLSDYLFIQPEVHYGHPAWSAIFLCVYMQSPCNWTHFEVRHVWPYGNCFTF---VVNNSRRDVKNMIKNAWRPDFKIIVYKGLTPTTQFSMDPFNNLNTPSGVLVMVHEADTYPYPDEGFIVDSYTQIDLKITTKVHLNVNNKCDMQRLNYEYYDFRTKKSAKFAGRQPDCVFDMIQTQIANRCKCLLQNMPVSKKFKHLPFC---LAVEVNETINNRDVDLNECIKSSFSFVDQGAINKK-CHRDLCSHPSFTTVVSHSKYPAVKERQTQYLWLEKLGELEKLQMRHYNISDLYLKALKPNLVKQYNISSLSQAIKIQNASKNVNFLEESFVDRNFMQIRVVPSSLFMDHIEETLEYTLSRLLGDIGGCIGLWIGASLITVFEFVDLIFRFGDLLSS---YRHRPVINQWDEKSKN 572
[Close]
BLAST of Acid-sensing ion channel 1 vs. Planmine SMEST
Match: SMESG000056126.1 (SMESG000056126.1)

HSP 1 Score: 389.037 bits (998), Expect = 5.322e-127
Identity = 217/540 (40.19%), Postives = 320/540 (59.26%), Query Frame = 2 
Query:  143 AQRTTVHGVNHLSQVKNQRGRIFWLMIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDHEMFEFPEISFCNLNPIFVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLA-------------SLSDFLYIQKK-QFSHPGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLSIYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYIFEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLGRWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIKN-------CLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMVWXXXXXXXXXXXXRKFNKSDLASKALINN-------SSLTLRQAYDQHRKDL--LNKDFVDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITVFELFDLILDSAEILYNNPYYQYKKMSTGVSKKSRN 1672
            ++++T+H ++HL+Q +N + R+FW +I  +A++GF INL  IIEKY +  VL+N YHD+  F FP+ISFC +NPI  PP GT++Y+ L    A Y K +N+  L +   A              LSD+L+IQ +  + HP WS I  C Y    C W +F    +WPYG CFTF    +N +R   K  I   +RP+F++I+YKG+    +   DP + +  PSG+L M+HE  +YPY  EG+++D ++ +DLKIT K H      C   R  Y Y D  T  S  + GR  DC++++IQ ++   C C+++  P+S +F  L FC   +     E I N       C+ ++F  + +  +    C++DLC H S+ TV+S +KYPAV+ER ++ +WL+KL E+E+L+MR +N SDL  KAL  N       SSL+         K++  L + FVDRNFM +RVV  SLFMD +EE  EY +SRLL DIGG +GLW+GASLITVFE  DLI    ++L +   Y+++ +     +KS+N
Sbjct:   35 SRQSTIHSLSHLAQARNIKQRMFWTIIALSASIGFLINLVNIIEKYYERPVLTNVYHDYRTFVFPDISFCLVNPIHFPPVGTRQYKQLEHQFAMYFKFRNSTHLKARQEALSFMMYKNYSLDIDLSDYLFIQPEVHYGHPAWSAIFLCVYMQSPCNWTHFEVRHVWPYGNCFTF---VVNNSRRDVKNMIKNAWRPDFKIIVYKGLTPTTQFSMDPFNNLNTPSGVLVMVHEADTYPYPDEGFIVDSYTQIDLKITTKVHLNVNNKCDMQRLNYEYYDFRTKKSAKFAGRQPDCVFDMIQTQIANRCKCLLQNMPVSKKFKHLPFC---LAVEVNETINNRDVDLNECIKSSFSFVDQGAINKK-CHRDLCSHPSFTTVVSHSKYPAVKERQTQYLWLEKLGELEKLQMRHYNISDLYLKALKPNLVKQYNISSLSQAIKIQNASKNVNFLEESFVDRNFMQIRVVPSSLFMDHIEETLEYTLSRLLGDIGGCIGLWIGASLITVFEFVDLIFRFGDLLSS---YRHRPVINQWDEKSKN 564
The following BLAST results are available for this feature:
BLAST of Acid-sensing ion channel 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SCNN1B4.580e-1423.24sodium channel epithelial 1 beta subunit [Source:H... [more]
SCNN1B4.858e-1423.24sodium channel epithelial 1 beta subunit [Source:H... [more]
SCNN1B5.021e-1423.24sodium channel epithelial 1 beta subunit [Source:H... [more]
ASIC52.483e-1221.72acid sensing ion channel subunit family member 5 [... [more]
ASIC29.617e-822.15acid sensing ion channel subunit 2 [Source:HGNC Sy... [more]
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BLAST of Acid-sensing ion channel 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
deg-15.206e-920.69Degenerin deg-1 [Source:UniProtKB/Swiss-Prot;Acc:... [more]
deg-15.206e-920.69Degenerin deg-1 [Source:UniProtKB/Swiss-Prot;Acc:... [more]
deg-15.206e-920.69Degenerin deg-1 [Source:UniProtKB/Swiss-Prot;Acc:... [more]
acd-16.151e-922.18pep chromosome:WBcel235:I:4103713:4108045:1 gene:W... [more]
F58G6.83.543e-732.43pep chromosome:WBcel235:IV:9643422:9644268:1 gene:... [more]
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BLAST of Acid-sensing ion channel 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Acid-sensing ion channel 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
asic1b2.360e-1120.11acid-sensing (proton-gated) ion channel 1b [Source... [more]
asic4b6.575e-835.21acid-sensing (proton-gated) ion channel family mem... [more]
asic4a1.170e-731.65acid-sensing (proton-gated) ion channel family mem... [more]
asic4a1.800e-731.65acid-sensing (proton-gated) ion channel family mem... [more]
asic1a1.983e-736.51acid-sensing (proton-gated) ion channel 1a [Source... [more]
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BLAST of Acid-sensing ion channel 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ASIC11.607e-1621.53acid sensing ion channel subunit 1 [Source:NCBI ge... [more]
ASIC55.565e-823.31acid sensing ion channel subunit family member 5 [... [more]
ASIC46.353e-832.14acid sensing ion channel subunit family member 4 [... [more]
cspg42.613e-732.29chondroitin sulfate proteoglycan 4 [Source:Xenbase... [more]
cspg43.346e-727.97chondroitin sulfate proteoglycan 4 [Source:Xenbase... [more]
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BLAST of Acid-sensing ion channel 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Scnn1b2.536e-1022.97sodium channel, nonvoltage-gated 1 beta [Source:MG... [more]
Asic25.183e-822.15acid-sensing (proton-gated) ion channel 2 [Source:... [more]
Asic49.890e-831.18acid-sensing (proton-gated) ion channel family mem... [more]
Asic41.061e-731.18acid-sensing (proton-gated) ion channel family mem... [more]
Asic21.077e-722.30acid-sensing (proton-gated) ion channel 2 [Source:... [more]
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BLAST of Acid-sensing ion channel 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q25011|FANA_CORAP3.213e-2222.06FMRFamide-activated amiloride-sensitive sodium cha... [more]
sp|Q9R0W5|ASIC5_RAT1.166e-1321.50Acid-sensing ion channel 5 OS=Rattus norvegicus OX... [more]
sp|P51168|SCNNB_HUMAN2.333e-1323.24Amiloride-sensitive sodium channel subunit beta OS... [more]
sp|Q95165|SCNNB_CANLF8.443e-1323.50Amiloride-sensitive sodium channel subunit beta OS... [more]
sp|O97742|SCNNB_RABIT1.550e-1224.16Amiloride-sensitive sodium channel subunit beta OS... [more]
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BLAST of Acid-sensing ion channel 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0R3SIE12.916e-13041.87Uncharacterized protein OS=Hymenolepis diminuta OX... [more]
A0A564Z6I13.352e-13041.87Uncharacterized protein OS=Hymenolepis diminuta OX... [more]
A0A0R3TJX97.878e-12440.93Uncharacterized protein OS=Rodentolepis nana OX=10... [more]
A0A3P7LUS42.589e-12142.80Uncharacterized protein OS=Dibothriocephalus latus... [more]
A0A183SCX11.671e-12041.32Uncharacterized protein OS=Schistocephalus solidus... [more]
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BLAST of Acid-sensing ion channel 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
asic4a3.350e-837.88acid-sensing ion channel 4 [Source:NCBI gene;Acc:1... [more]
asic4b3.654e-837.88acid-sensing ion channel 4 [Source:NCBI gene;Acc:1... [more]
asic21.467e-723.44acid-sensing (proton-gated) ion channel 2 [Source:... [more]
asic4a2.170e-736.11acid-sensing ion channel 4 [Source:NCBI gene;Acc:1... [more]
asic1c3.159e-721.88acid-sensing ion channel 1C-like [Source:NCBI gene... [more]
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BLAST of Acid-sensing ion channel 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
asic1a6.823e-1521.58acid-sensing (proton-gated) ion channel 1a [Source... [more]
SCNN1B7.821e-819.51sodium channel epithelial 1 beta subunit [Source:H... [more]
asic1b6.604e-630.00acid-sensing (proton-gated) ion channel 1b [Source... [more]
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BLAST of Acid-sensing ion channel 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Acid-sensing ion channel 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO394137.374e-1421.92Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO361919.505e-920.37Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO308921.252e-821.51Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO486565.599e-835.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO486581.714e-736.67Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Acid-sensing ion channel 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSORLT00000015581.26.173e-1721.39acid-sensing ion channel 1C [Source:NCBI gene;Acc:... [more]
asic4a4.474e-832.10acid sensing ion channel subunit family member 4 [... [more]
ENSORLT00000035361.12.684e-734.92acid-sensing ion channel 1C [Source:NCBI gene;Acc:... [more]
ENSORLT00000021925.22.687e-736.67acid-sensing ion channel 1C [Source:NCBI gene;Acc:... [more]
ENSORLT00000021936.22.871e-736.07acid-sensing ion channel 1C [Source:NCBI gene;Acc:... [more]
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BLAST of Acid-sensing ion channel 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000016710.10.000e+0100.00SMESG000016710.1[more]
SMESG000047581.13.394e-15044.17SMESG000047581.1[more]
SMESG000009914.12.222e-13841.20SMESG000009914.1[more]
SMESG000056126.14.974e-12740.19SMESG000056126.1[more]
SMESG000056126.15.322e-12740.19SMESG000056126.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30023659 ID=SMED30023659|Name=Acid-sensing ion channel 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1939bp
ATTTTACCAAGATTTATAATGAGGATATTTCATTTGATGTAAATTATAAA
ACCCCCATTAATTCTGAAACTGACAATCCGAACTTTTTGAATAATTTAAA
CAATGCGCCGATCCCAAAACGTATGCCGATTCCTCATTCAATGCGCAACG
AACTACCGTTCACGGAGTCAATCATTTGTCACAAGTCAAAAACCAGAGAG
GTCGGATTTTCTGGTTGATGATCGTTTCGGCCGCCGCGTTAGGTTTCACG
ATAAATCTCTTTCAAATCATTGAGAAATACCTCCAATACCAAGTTCTCAG
CAATACCTATCACGATCATGAAATGTTTGAGTTTCCGGAGATTTCGTTTT
GTAACTTAAATCCAATTTTTGTGCCTCCATCCGGCACGAAAGAATATCAA
AATCTCCTTCGTTGGATTGCAGAGTATCCAAAAGTTAAAAACAACCAAAC
TTTGGCTAGCTCTTATCTAGCTAGTTTAAGTGACTTTCTCTATATTCAAA
AGAAACAATTCAGTCATCCTGGATGGTCCTTGATTGCTCACTGTCGGTAT
CAAACTAAAGTATGTACCTGGATTAATTTTACACCAATTACATTGTGGCC
CTATGGCACTTGTTTTACATTTAATCCTAACTCAATGAACATGACCCGAG
TGGCTCAAAAGCTTTCCATTTATAGAGGGTATCGTCCAAACTTTGAAGTT
ATTTTATATAAAGGTATAGATTTCCCGTTAGAAATGAAACAAGATCCACA
TCATACCGTTACAATGCCAAGTGGAATTCTTTTCATGATGCATGAACCAC
AGTCATATCCTTATATATTTGAAGGTTACCTTTTGGATTTCTTTAGTGTC
GTAGATTTAAAGATAACCCGTAAATTTCACGAACCAAAATTAAAGCCTTG
TATTAAAACTCGAACATATTATACATATGTTGACCCCATCACAAATACTA
GCAAAACATACTTAGGTAGATGGGCAGATTGTATATATAATATCATTCAA
AATGAAGTGAAAAAGTCCTGCAATTGTGTCATGGAACAATATCCCATTTC
AATGGAATTTAATGGGCTAGAATTCTGCAAGTCTTCCATGCTCTGCCATT
CTGCTGAATACATTAAGAACTGTCTGGGAAATGCCTTTAAAGCCATCTTT
AAAAATGAAGTGAAAATGAATCTATGCTACAAAGATCTTTGTGATCACAG
TTCTTATCAAACCGTTATATCCCAAGCTAAATATCCAGCCGTTGAAGAAC
GAAACTCTGAAATGGTTTGGTTAAAAAAGCTTACCGAAATGGAAGAATTA
GAAATGAGAAAATTCAACAAATCAGACTTGGCTTCAAAAGCTCTTATTAA
TAACTCATCGTTGACGTTGCGACAGGCTTATGATCAACATCGTAAAGATT
TATTAAACAAGGATTTTGTCGATCGAAATTTTATGCTCCTTCGAGTAGTG
GCACAGTCACTTTTTATGGACAAAGTAGAAGAAGTTGAAGAATATCCCAT
CAGTAGGCTGTTAAGTGACATTGGCGGCATTGTCGGCTTGTGGCTAGGTG
CAAGTTTGATAACAGTTTTTGAACTTTTTGATTTGATTCTCGACAGTGCT
GAAATATTGTACAATAATCCGTATTATCAGTACAAGAAAATGAGTACGGG
GGTAAGTAAAAAATCAAGAAATCATCTCCTTTATAGGTCTAATACAAAAT
ACGATGAAATCGTAAAGCTAAACTCAAATATTGTAACAATAAATAAATGG
AAAGATGACGTTTGTTGCAGTTCTCCACCTGATAATCGTATTTTTGGAGA
TAATAATTGCATAAATACTTCTAATAGTTTAAATAATGAAGATTTGACAA
AATTGCGACCCAGATCTAAATCTTTGAAAGATGACTACAATATTGTTTCA
ACTGTGTAATATTTATTAAAAATATATCACCAAATTACC
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protein sequence of SMED30023659-orf-1

>SMED30023659-orf-1 ID=SMED30023659-orf-1|Name=SMED30023659-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=564bp
MIVSAAALGFTINLFQIIEKYLQYQVLSNTYHDHEMFEFPEISFCNLNPI
FVPPSGTKEYQNLLRWIAEYPKVKNNQTLASSYLASLSDFLYIQKKQFSH
PGWSLIAHCRYQTKVCTWINFTPITLWPYGTCFTFNPNSMNMTRVAQKLS
IYRGYRPNFEVILYKGIDFPLEMKQDPHHTVTMPSGILFMMHEPQSYPYI
FEGYLLDFFSVVDLKITRKFHEPKLKPCIKTRTYYTYVDPITNTSKTYLG
RWADCIYNIIQNEVKKSCNCVMEQYPISMEFNGLEFCKSSMLCHSAEYIK
NCLGNAFKAIFKNEVKMNLCYKDLCDHSSYQTVISQAKYPAVEERNSEMV
WLKKLTEMEELEMRKFNKSDLASKALINNSSLTLRQAYDQHRKDLLNKDF
VDRNFMLLRVVAQSLFMDKVEEVEEYPISRLLSDIGGIVGLWLGASLITV
FELFDLILDSAEILYNNPYYQYKKMSTGVSKKSRNHLLYRSNTKYDEIVK
LNSNIVTINKWKDDVCCSSPPDNRIFGDNNCINTSNSLNNEDLTKLRPRS
KSLKDDYNIVSTV*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: cellular component
TermDefinition
GO:0005886plasma membrane
GO:0005887integral component of plasma membrane
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: molecular function
TermDefinition
GO:0015280ligand-gated sodium channel activity
GO:0044736acid-sensing ion channel activity
GO:0005272sodium channel activity
Vocabulary: biological process
TermDefinition
GO:0070207protein homotrimerization
GO:0071467cellular response to pH
GO:0006814sodium ion transport
GO:0006810transport
GO:0006811ion transport
GO:0035725sodium ion transmembrane transport
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000140anterior region of the whole animal
PLANA:0000420parapharyngeal region
PLANA:0003001lateral region of the whole animal
Vocabulary: INTERPRO
TermDefinition
IPR001873ENaC
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001873Epithelial sodium channelPRINTSPR01078AMINACHANNELcoord: 106..117
score: 27.67
coord: 321..341
score: 25.9
coord: 35..51
score: 39.53
coord: 261..278
score: 29.78
coord: 120..136
score: 43.29
IPR001873Epithelial sodium channelPFAMPF00858ASCcoord: 2..456
e-value: 8.4E-50
score: 170.0
IPR001873Epithelial sodium channelPANTHERPTHR11690AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATEDcoord: 6..461
NoneNo IPR availableGENE3DG3DSA:2.60.470.10coord: 26..424
e-value: 6.6E-41
score: 142.6
NoneNo IPR availableGENE3DG3DSA:1.10.287.820coord: 220..325
e-value: 6.6E-41
score: 142.6
NoneNo IPR availableGENE3DG3DSA:1.10.3590.10coord: 48..186
e-value: 6.6E-41
score: 142.6
NoneNo IPR availableGENE3DG3DSA:1.10.287.770coord: 2..454
e-value: 6.6E-41
score: 142.6
NoneNo IPR availableCDDcd06226M14_CPT_likecoord: 126..164
e-value: 0.00298066
score: 37.4337