Heat shock factor-binding protein

Overview


Name	Heat shock factor-binding protein
Smed ID	SMED30023628
Length (bp)	407

Neoblast Clusters

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30023628

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30023628	SMESG000032253.1	dd_Smed_v4_15016_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30023628	SMESG000032253.1	dd_Smed_v4_15016_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30023628	SMESG000032253.1	dd_Smed_v4_15016_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of Heat shock factor-binding protein vs. Ensembl Human
Match: HSBP1 (heat shock factor binding protein 1 [Source:HGNC Symbol;Acc:HGNC:5203])

HSP 1 Score: 56.9954 bits (136), Expect = 3.138e-11
Identity = 30/88 (34.09%), Postives = 49/88 (55.68%), Query Frame = 1

Query:  121 NDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
             DP+++Q+L+  +Q +LQQMQD FQ M+D+I  R                             +DDM  +ID++E+++A+LMTQAG++
Sbjct:    4 TDPKTVQDLTSVVQTLLQQMQDKFQTMSDQIIGR-----------------------------IDDMSSRIDDLEKNIADLMTQAGVE 62

[Close]

Query:  121 NDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
             DP+++Q+L+  +Q +LQQMQD FQ M+D+I  R                             +DDM  +ID++E+++A+LMTQAG++
Sbjct:    4 TDPKTVQDLTSVVQTLLQQMQDKFQTMSDQIIGR-----------------------------IDDMSSRIDDLEKNIADLMTQAGVE 62

[Close]

BLAST of Heat shock factor-binding protein vs. Ensembl Fly
Match: CG5446 (gene:FBgn0032429 transcript:FBtr0333094)

HSP 1 Score: 63.929 bits (154), Expect = 3.316e-14
Identity = 38/105 (36.19%), Postives = 63/105 (60.00%), Query Frame = 1

Query:   82 KMSAAVKEN-NINTN-DPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGIDLQ 390
            +M + + +N ++N+N DP+++QEL++Y+Q +LQ +QD FQ M+D+I TR                             +DDMG +ID++E+S+A+LM QAGI+ Q
Sbjct:    7 EMDSDLDQNYSLNSNADPKNMQELTIYVQNLLQNVQDKFQTMSDQIITR-----------------------------IDDMGNRIDDLEKSIADLMNQAGIEGQ 82

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BLAST of Heat shock factor-binding protein vs. Ensembl Fly
Match: CG5446 (gene:FBgn0032429 transcript:FBtr0080388)

HSP 1 Score: 63.929 bits (154), Expect = 3.316e-14
Identity = 38/105 (36.19%), Postives = 63/105 (60.00%), Query Frame = 1

Query:   82 KMSAAVKEN-NINTN-DPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGIDLQ 390
            +M + + +N ++N+N DP+++QEL++Y+Q +LQ +QD FQ M+D+I TR                             +DDMG +ID++E+S+A+LM QAGI+ Q
Sbjct:    7 EMDSDLDQNYSLNSNADPKNMQELTIYVQNLLQNVQDKFQTMSDQIITR-----------------------------IDDMGNRIDDLEKSIADLMNQAGIEGQ 82

[Close]

BLAST of Heat shock factor-binding protein vs. Ensembl Fly
Match: CG5446 (gene:FBgn0032429 transcript:FBtr0333093)

HSP 1 Score: 50.8322 bits (120), Expect = 3.244e-9
Identity = 33/94 (35.11%), Postives = 51/94 (54.26%), Query Frame = 1

Query:  112 INTN-DPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGIDLQ 390
            +N+N DP+++QEL++Y       +QD FQ M+D+I TR                             +DDMG +ID++E+S+A+LM QAGI+ Q
Sbjct:   18 LNSNADPKNMQELTIY------NVQDKFQTMSDQIITR-----------------------------IDDMGNRIDDLEKSIADLMNQAGIEGQ 76

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BLAST of Heat shock factor-binding protein vs. Ensembl Zebrafish
Match: hsbp1b (heat shock factor binding protein 1b [Source:ZFIN;Acc:ZDB-GENE-040426-1721])

HSP 1 Score: 56.6102 bits (135), Expect = 2.726e-11
Identity = 30/88 (34.09%), Postives = 49/88 (55.68%), Query Frame = 1

Query:  121 NDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
             DP+S+Q+L+  +Q +LQQMQD FQ M+D+I  R                             +D+M  +ID++E+++A+LMTQAG++
Sbjct:    4 TDPKSVQDLTAVVQTLLQQMQDKFQTMSDQIIGR-----------------------------IDEMSTRIDDLEKNIADLMTQAGVE 62

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BLAST of Heat shock factor-binding protein vs. Ensembl Zebrafish
Match: hsbp1a (heat shock factor binding protein 1a [Source:ZFIN;Acc:ZDB-GENE-050320-136])

HSP 1 Score: 54.299 bits (129), Expect = 2.286e-10
Identity = 29/91 (31.87%), Postives = 51/91 (56.04%), Query Frame = 1

Query:  112 INTNDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
            ++  DP+S Q+L++ +Q +LQQMQD FQ M+D+I  R                             +D+M  +ID++E+++++LMTQAG++
Sbjct:    1 MSEKDPKSSQDLTVVVQTLLQQMQDKFQTMSDQIIGR-----------------------------IDEMSTRIDDLEKNISDLMTQAGVE 62

[Close]

Query:  112 INTNDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
            ++  DP+S Q+L++ +Q +LQQMQD FQ M+D+I  R                             +D+M  +ID++E+++++LMTQAG++
Sbjct:    1 MSEKDPKSSQDLTVVVQTLLQQMQDKFQTMSDQIIGR-----------------------------IDEMSTRIDDLEKNISDLMTQAGVE 62

[Close]

BLAST of Heat shock factor-binding protein vs. Ensembl Zebrafish
Match: hsbp1b (heat shock factor binding protein 1b [Source:ZFIN;Acc:ZDB-GENE-040426-1721])

HSP 1 Score: 43.1282 bits (100), Expect = 2.395e-6
Identity = 25/76 (32.89%), Postives = 40/76 (52.63%), Query Frame = 1

Query:  157 LQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
            +Q +LQQMQD FQ M+D+I  R                             +D+M  +ID++E+++A+LMTQAG++
Sbjct:    2 VQTLLQQMQDKFQTMSDQIIGR-----------------------------IDEMSTRIDDLEKNIADLMTQAGVE 48

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BLAST of Heat shock factor-binding protein vs. Ensembl Xenopus
Match: hsbp1 (heat shock factor binding protein 1 [Source:NCBI gene;Acc:496903])

HSP 1 Score: 59.3066 bits (142), Expect = 2.697e-12
Identity = 31/91 (34.07%), Postives = 52/91 (57.14%), Query Frame = 1

Query:  112 INTNDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
            ++  DP+++Q+L++ +Q +LQQMQD FQ M+D+I  R                             +DDM  +ID++E+++A+LMTQAG+D
Sbjct:    1 MSETDPKTVQDLTVVVQNLLQQMQDKFQTMSDQIIGR-----------------------------IDDMSTRIDDLEKNIADLMTQAGVD 62

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BLAST of Heat shock factor-binding protein vs. Ensembl Mouse
Match: Hsbp1 (heat shock factor binding protein 1 [Source:MGI Symbol;Acc:MGI:1915446])

HSP 1 Score: 55.4546 bits (132), Expect = 8.606e-11
Identity = 29/88 (32.95%), Postives = 50/88 (56.82%), Query Frame = 1

Query:  121 NDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
             DP+++Q+++L ++ +LQQMQD FQ M+D+I  R                             +DDM  +ID++E+++A+LMTQAG++
Sbjct:    4 TDPKTMQDITLVVETLLQQMQDKFQIMSDQIIGR-----------------------------IDDMSSRIDDLEKNIADLMTQAGVE 62

[Close]

Query:  121 NDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
             DP+++Q+++L ++ +LQQMQD FQ M+D+I  R                             +DDM  +ID++E+++A+LMTQAG++
Sbjct:    4 TDPKTMQDITLVVETLLQQMQDKFQIMSDQIIGR-----------------------------IDDMSSRIDDLEKNIADLMTQAGVE 62

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BLAST of Heat shock factor-binding protein vs. UniProt/SwissProt
Match: sp|Q8K3X8|HSBP1_RAT (Heat shock factor-binding protein 1 OS=Rattus norvegicus OX=10116 GN=Hsbp1 PE=3 SV=1)

HSP 1 Score: 55.4546 bits (132), Expect = 5.293e-10
Identity = 29/88 (32.95%), Postives = 50/88 (56.82%), Query Frame = 1

Query:  121 NDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
             DP+++Q+++L ++ +LQQMQD FQ M+D+I  R                             +DDM  +ID++E+++A+LMTQAG++
Sbjct:    4 TDPKTMQDITLVVETLLQQMQDKFQIMSDQIIGR-----------------------------IDDMSSRIDDLEKNIADLMTQAGVE 62

[Close]

BLAST of Heat shock factor-binding protein vs. UniProt/SwissProt
Match: sp|Q9CQZ1|HSBP1_MOUSE (Heat shock factor-binding protein 1 OS=Mus musculus OX=10090 GN=Hsbp1 PE=1 SV=1)

HSP 1 Score: 55.4546 bits (132), Expect = 6.020e-10
Identity = 29/88 (32.95%), Postives = 50/88 (56.82%), Query Frame = 1

Query:  121 NDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
             DP+++Q+++L ++ +LQQMQD FQ M+D+I  R                             +DDM  +ID++E+++A+LMTQAG++
Sbjct:    4 TDPKTMQDITLVVETLLQQMQDKFQIMSDQIIGR-----------------------------IDDMSSRIDDLEKNIADLMTQAGVE 62

[Close]

BLAST of Heat shock factor-binding protein vs. TrEMBL
Match: A0A1L8GF50 (Uncharacterized protein OS=Xenopus laevis OX=8355 GN=XELAEV_18024934mg PE=4 SV=1)

HSP 1 Score: 78.9518 bits (193), Expect = 2.805e-16
Identity = 39/88 (44.32%), Postives = 60/88 (68.18%), Query Frame = 1

Query:  121 NDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
             DP+++Q+L++ +Q +LQQMQD FQ M+D+I  RNILL          F L      F++  LLDDM  +ID++E+++A+LMTQAG++
Sbjct:    4 TDPKTVQDLTVVVQNLLQQMQDKFQTMSDQIIGRNILLV--------TFLLARLYRSFSLTKLLDDMSTRIDDLEKNIADLMTQAGVE 83

[Close]

BLAST of Heat shock factor-binding protein vs. TrEMBL
Match: A0A1L8GL11 (Uncharacterized protein OS=Xenopus laevis OX=8355 GN=XELAEV_18022656mg PE=4 SV=1)

HSP 1 Score: 75.0998 bits (183), Expect = 1.203e-14
Identity = 38/91 (41.76%), Postives = 61/91 (67.03%), Query Frame = 1

Query:  112 INTNDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
            ++  DP+++Q+L++ +Q +LQQMQD FQ M+D+I  RNILL Y                 F++  LLDDM  +ID++E+++A+LMTQAG++
Sbjct:    1 MSETDPKTVQDLTVVVQNLLQQMQDKFQTMSDQIIGRNILLLYRS---------------FSLTKLLDDMSTRIDDLEKNIADLMTQAGVE 76

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BLAST of Heat shock factor-binding protein vs. TrEMBL
Match: A0A195DA13 (Heat shock factor-binding protein 1 OS=Trachymyrmex cornetzi OX=471704 GN=ALC57_18244 PE=4 SV=1)

HSP 1 Score: 74.3294 bits (181), Expect = 1.454e-14
Identity = 38/90 (42.22%), Postives = 62/90 (68.89%), Query Frame = 1

Query:  115 NTNDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
            N+ DP+++QEL+ Y+Q +LQ MQD FQ M+D+I  RN+ +          F + P S F +   +LD+MG +ID++E+++A+LMTQAG++
Sbjct:   20 NSADPKNMQELTQYVQTLLQNMQDKFQTMSDQIIGRNMHV--------KFFAVLPSSLFIS-EQILDEMGNRIDDLEKNIADLMTQAGVE 100

[Close]

BLAST of Heat shock factor-binding protein vs. TrEMBL
Match: A0A151XES6 (Heat shock factor-binding protein 1 OS=Trachymyrmex zeteki OX=64791 GN=ALC60_02438 PE=4 SV=1)

HSP 1 Score: 73.1738 bits (178), Expect = 7.251e-14
Identity = 39/105 (37.14%), Postives = 62/105 (59.05%), Query Frame = 1

Query:  115 NTNDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFS---------FFFNIPFL------LDDMGQKIDEIERSVANLMTQAGID 384
            N+ DP+++QEL+ Y+Q +LQ MQD FQ M+D+I  RNIL     +        N  S          +  + +L      LD+MG +ID++E+++A+LMTQAG++
Sbjct:   20 NSADPKNMQELTQYVQTLLQNMQDKFQTMSDQIIGRNILFLMLNLKRCCSLSCNWLSVVLIASSFLLYCQVDYLSLNVKILDEMGNRIDDLEKNIADLMTQAGVE 124

[Close]

BLAST of Heat shock factor-binding protein vs. TrEMBL
Match: A0A2G9SJP3 (Uncharacterized protein OS=Lithobates catesbeianus OX=8400 GN=AB205_0019410 PE=4 SV=1)

HSP 1 Score: 72.4034 bits (176), Expect = 1.026e-13
Identity = 36/97 (37.11%), Postives = 61/97 (62.89%), Query Frame = 1

Query:  115 NTNDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXX-------XXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
            ++ DP+++Q+L+  +Q +LQQMQD FQ M+D+I  RNIL +                 C +P  +  ++   LD+M  +ID++E+++A+LMTQAG+D
Sbjct:    3 DSADPKTVQDLTEVVQNLLQQMQDKFQTMSDQIIGRNILSWTQGVYCGDLVSLYKCDLCTSPL-YVLSLIQTLDEMSTRIDDLEKNIADLMTQAGVD 98

[Close]

BLAST of Heat shock factor-binding protein vs. Ensembl Cavefish
Match: hsbp1b (heat shock factor binding protein 1b [Source:ZFIN;Acc:ZDB-GENE-040426-1721])

HSP 1 Score: 55.4546 bits (132), Expect = 5.991e-11
Identity = 31/87 (35.63%), Postives = 48/87 (55.17%), Query Frame = 1

Query:  124 DPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
            DP+S+Q+L+  +Q +LQQMQD FQ M+D+I  RNIL                                +ID++E+++A+LMTQAG++
Sbjct:    5 DPKSVQDLTGVVQTLLQQMQDKFQTMSDQIIGRNILFT------------------------------RIDDLEKNIADLMTQAGVE 61

[Close]

BLAST of Heat shock factor-binding protein vs. Ensembl Nematostella
Match: EDO35978 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJY7])

HSP 1 Score: 50.0618 bits (118), Expect = 2.200e-9
Identity = 29/98 (29.59%), Postives = 51/98 (52.04%), Query Frame = 1

Query:   91 AAVKENNINTNDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
            A  K  + +  +P+++Q+L+ ++Q +L QMQD FQ M+D+I TR                             +D+M  +ID++E+++  LM QAG+D
Sbjct:    2 ADTKIKSGDVENPENLQDLTGFVQTLLTQMQDKFQNMSDQIITR-----------------------------IDEMSNRIDDLEKNIGELMNQAGVD 70

[Close]

BLAST of Heat shock factor-binding protein vs. Ensembl Medaka
Match: hsbp1a (heat shock factor binding protein 1 [Source:NCBI gene;Acc:101175153])

HSP 1 Score: 55.0694 bits (131), Expect = 9.413e-11
Identity = 30/88 (34.09%), Postives = 49/88 (55.68%), Query Frame = 1

Query:  121 NDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID 384
             DP+S+Q+L+  +Q +LQQMQD FQ M+D+I  R                             +D+M  +ID++E+++A+LMTQAG++
Sbjct:    4 TDPKSVQDLTNVVQTLLQQMQDKFQTMSDQIIGR-----------------------------IDEMSTRIDDLEKNIADLMTQAGVE 62

[Close]

BLAST of Heat shock factor-binding protein vs. Planmine SMEST
Match: SMESG000032253.1 (SMESG000032253.1)

HSP 1 Score: 181.415 bits (459), Expect = 2.241e-60
Identity = 101/102 (99.02%), Postives = 101/102 (99.02%), Query Frame = 1

Query:   85 MSAAVKENNINTNDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGIDLQ 390
            MSAAVKENNINTNDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFYYYIHIIYIFCLN FSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGIDLQ
Sbjct:    1 MSAAVKENNINTNDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFYYYIHIIYIFCLNSFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGIDLQ 102

HSP 2 Score: 55.8398 bits (133), Expect = 5.587e-11
Identity = 27/27 (100.00%), Postives = 27/27 (100.00%), Query Frame = -3

Query:    1 NNINTNDPQSIQELSLYLQGMLQQMQD 81
            NNINTNDPQSIQELSLYLQGMLQQMQD
Sbjct:    8 NNINTNDPQSIQELSLYLQGMLQQMQD 34

[Close]

BLAST of Heat shock factor-binding protein vs. Planmine SMEST
Match: SMESG000030373.1 (SMESG000030373.1)

HSP 1 Score: 45.8246 bits (107), Expect = 1.859e-7
Identity = 20/58 (34.48%), Postives = 34/58 (58.62%), Query Frame = 1

Query:   97 VKENNINTNDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILLFXXXXXXXXXFC 270
             +++     DPQ+ QEL+ Y++ ++QQMQDN  ++++KI   NILL          +C
Sbjct:    9 ARDSKFGIADPQTPQELAHYIERIMQQMQDNVDRVSEKINNNNILLLVSRNLNFISYC 66

The following BLAST results are available for this feature:

BLAST of Heat shock factor-binding protein vs. Ensembl Human
BLAST of Heat shock factor-binding protein vs. Ensembl Celegans
BLAST of Heat shock factor-binding protein vs. Ensembl Fly
BLAST of Heat shock factor-binding protein vs. Ensembl Zebrafish
BLAST of Heat shock factor-binding protein vs. Ensembl Xenopus
BLAST of Heat shock factor-binding protein vs. Ensembl Mouse
BLAST of Heat shock factor-binding protein vs. UniProt/SwissProt
BLAST of Heat shock factor-binding protein vs. TrEMBL
BLAST of Heat shock factor-binding protein vs. Ensembl Cavefish
BLAST of Heat shock factor-binding protein vs. Ensembl Sea Lamprey
BLAST of Heat shock factor-binding protein vs. Ensembl Yeast
BLAST of Heat shock factor-binding protein vs. Ensembl Nematostella
BLAST of Heat shock factor-binding protein vs. Ensembl Medaka
BLAST of Heat shock factor-binding protein vs. Planmine SMEST

BLAST of Heat shock factor-binding protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2


Match Name	E-value	Identity	Description
HSBP1	3.138e-11	34.09	heat shock factor binding protein 1 [Source:HGNC S...	[more]
HSBP1	3.138e-11	34.09	heat shock factor binding protein 1 [Source:HGNC S...	[more]

BLAST of Heat shock factor-binding protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Heat shock factor-binding protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3


Match Name	E-value	Identity	Description
CG5446	3.316e-14	36.19	gene:FBgn0032429 transcript:FBtr0333094	[more]
CG5446	3.316e-14	36.19	gene:FBgn0032429 transcript:FBtr0080388	[more]
CG5446	3.244e-9	35.11	gene:FBgn0032429 transcript:FBtr0333093	[more]

BLAST of Heat shock factor-binding protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
hsbp1b	2.726e-11	34.09	heat shock factor binding protein 1b [Source:ZFIN;...	[more]
hsbp1a	2.286e-10	31.87	heat shock factor binding protein 1a [Source:ZFIN;...	[more]
hsbp1a	2.286e-10	31.87	heat shock factor binding protein 1a [Source:ZFIN;...	[more]
hsbp1b	2.395e-6	32.89	heat shock factor binding protein 1b [Source:ZFIN;...	[more]

BLAST of Heat shock factor-binding protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1


Match Name	E-value	Identity	Description
hsbp1	2.697e-12	34.07	heat shock factor binding protein 1 [Source:NCBI g...	[more]

BLAST of Heat shock factor-binding protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2


Match Name	E-value	Identity	Description
Hsbp1	8.606e-11	32.95	heat shock factor binding protein 1 [Source:MGI Sy...	[more]
Hsbp1	8.606e-11	32.95	heat shock factor binding protein 1 [Source:MGI Sy...	[more]

BLAST of Heat shock factor-binding protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 2


Match Name	E-value	Identity	Description
sp\|Q8K3X8\|HSBP1_RAT	5.293e-10	32.95	Heat shock factor-binding protein 1 OS=Rattus norv...	[more]
sp\|Q9CQZ1\|HSBP1_MOUSE	6.020e-10	32.95	Heat shock factor-binding protein 1 OS=Mus musculu...	[more]

BLAST of Heat shock factor-binding protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1L8GF50	2.805e-16	44.32	Uncharacterized protein OS=Xenopus laevis OX=8355 ...	[more]
A0A1L8GL11	1.203e-14	41.76	Uncharacterized protein OS=Xenopus laevis OX=8355 ...	[more]
A0A195DA13	1.454e-14	42.22	Heat shock factor-binding protein 1 OS=Trachymyrme...	[more]
A0A151XES6	7.251e-14	37.14	Heat shock factor-binding protein 1 OS=Trachymyrme...	[more]
A0A2G9SJP3	1.026e-13	37.11	Uncharacterized protein OS=Lithobates catesbeianus...	[more]

BLAST of Heat shock factor-binding protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
hsbp1b	5.991e-11	35.63	heat shock factor binding protein 1b [Source:ZFIN;...	[more]

BLAST of Heat shock factor-binding protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Heat shock factor-binding protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Heat shock factor-binding protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO35978	2.200e-9	29.59	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Heat shock factor-binding protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
hsbp1a	9.413e-11	34.09	heat shock factor binding protein 1 [Source:NCBI g...	[more]

BLAST of Heat shock factor-binding protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2


Match Name	E-value	Identity	Description
SMESG000032253.1	2.241e-60	99.02	SMESG000032253.1	[more]
SMESG000030373.1	1.859e-7	34.48	SMESG000030373.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30023628 ID=SMED30023628|Name=Heat shock factor-binding protein|organism=Schmidtea mediterranea sexual|type=transcript|length=407bp
GTCCTGCATTTGTTGAAGCATTCCTTGTAAATATAATGAAAGTTCCTGGA
TCGACTGAGGATCATTTGTGTTTATATTATTAAAATGTCAGCAGCTGTCA
AAGAAAATAATATAAACACAAATGATCCTCAGTCGATCCAGGAACTTTCA
TTATATTTACAAGGAATGCTTCAACAAATGCAGGACAATTTCCAGAAAAT
GACGGACAAGATTACTACAAGAAATATCCTTTTATTTTATTATTATATAC
ATATAATTTATATTTTTTGTTTAAATCCATTTAGTTTTTTCTTTAACATT
CCATTTCTACTAGATGATATGGGCCAGAAAATTGATGAAATAGAACGAAG
CGTAGCCAATCTGATGACCCAAGCTGGAATTGATCTACAATGAATAATAA
ATGCATT

protein sequence of SMED30023628-orf-1

>SMED30023628-orf-1 ID=SMED30023628-orf-1|Name=SMED30023628-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=103bp
MSAAVKENNINTNDPQSIQELSLYLQGMLQQMQDNFQKMTDKITTRNILL
FYYYIHIIYIFCLNPFSFFFNIPFLLDDMGQKIDEIERSVANLMTQAGID
LQ*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **INTERPRO**
Term	Definition
IPR009643	HS1-bd

Vocabulary: **molecular function**
Term	Definition
GO:0003714	transcription corepressor activity

Vocabulary: **biological process**
Term	Definition
GO:1903507	negative regulation of nucleic acid-templated transcription

Main menu

Heat shock factor-binding protein

Zeng et. al., 2018

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Owlery

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