Cathepsin L2
|
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30023605 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 9
Homology
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSV (cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538]) HSP 1 Score: 328.176 bits (840), Expect = 3.527e-110 Identity = 163/339 (48.08%), Postives = 218/339 (64.31%), Query Frame = 1
Query: 73 MHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMK-FGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL 1080
M+ ++ A +P F Q D W ++K ++Y E RR +WE+N++ I+ HN EY+ G+H +T+ +N F D++++EF + +R + + ++ L LP SV+W KKGYVTPVKNQ QCGSCWAFS TG++EGQ F+KT KLVS SEQ LVDCS+ GN+GCNGGFM +AFQY+ + G++ E YPY A+D C+Y + +T + G E+ L + +ATVGPISV +DA + SFQ Y GIY E CSS LDHGVL VGYG + + KYWLVKNSWG WG NGY+K++KDKNN CGIAT ASYPN+
Sbjct: 1 MNLSLVLAAFCLGIASAVP---KFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRN--QKFRKGKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSV (cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538]) HSP 1 Score: 328.176 bits (840), Expect = 3.527e-110 Identity = 163/339 (48.08%), Postives = 218/339 (64.31%), Query Frame = 1
Query: 73 MHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMK-FGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL 1080
M+ ++ A +P F Q D W ++K ++Y E RR +WE+N++ I+ HN EY+ G+H +T+ +N F D++++EF + +R + + ++ L LP SV+W KKGYVTPVKNQ QCGSCWAFS TG++EGQ F+KT KLVS SEQ LVDCS+ GN+GCNGGFM +AFQY+ + G++ E YPY A+D C+Y + +T + G E+ L + +ATVGPISV +DA + SFQ Y GIY E CSS LDHGVL VGYG + + KYWLVKNSWG WG NGY+K++KDKNN CGIAT ASYPN+
Sbjct: 1 MNLSLVLAAFCLGIASAVP---KFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRN--QKFRKGKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSL (cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537]) HSP 1 Score: 308.916 bits (790), Expect = 1.391e-102 Identity = 156/332 (46.99%), Postives = 215/332 (64.76%), Query Frame = 1
Query: 97 LIVPCFAETIPWSGIFF-QGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL 1080
LI+ F I + + F + W+++K N++Y E RR +WE+N++ I+ HN EY G+H +T+ +N F D++ +EF + ++ K + K F ++ + P SV+W +KGYVTPVKNQ QCGSCWAFS TG++EGQ F+KT +L+S SEQ LVDCS GNEGCNGG MD AFQY+ G++ E YPY A + +C+Y+ + + + DI + E+ L + +ATVGPISV IDA + SF Y GIY E CSS +DHGVL VGYG + E KYWLVKNSWG+ WG+ GY+KM+KD+ N CGIA+ ASYP +
Sbjct: 5 LILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQN-RKPRKGKVF-QEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSL (cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537]) HSP 1 Score: 308.916 bits (790), Expect = 1.391e-102 Identity = 156/332 (46.99%), Postives = 215/332 (64.76%), Query Frame = 1
Query: 97 LIVPCFAETIPWSGIFF-QGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL 1080
LI+ F I + + F + W+++K N++Y E RR +WE+N++ I+ HN EY G+H +T+ +N F D++ +EF + ++ K + K F ++ + P SV+W +KGYVTPVKNQ QCGSCWAFS TG++EGQ F+KT +L+S SEQ LVDCS GNEGCNGG MD AFQY+ G++ E YPY A + +C+Y+ + + + DI + E+ L + +ATVGPISV IDA + SF Y GIY E CSS +DHGVL VGYG + E KYWLVKNSWG+ WG+ GY+KM+KD+ N CGIA+ ASYP +
Sbjct: 5 LILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQN-RKPRKGKVF-QEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSS (cathepsin S [Source:HGNC Symbol;Acc:HGNC:2545]) HSP 1 Score: 291.967 bits (746), Expect = 5.982e-96 Identity = 148/312 (47.44%), Postives = 203/312 (65.06%), Query Frame = 1
Query: 154 FDELWSEYKTKFNKVYDEENE-FVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCS-QSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL 1080
D W +K + K Y E+NE VRR IWE+NL+F+ HN+E+++G H Y LG+N D++ +E + + R + +R K + LP+SV+W +KG VT VK Q CG+CWAFS G++E Q KT KLVS S Q LVDCS + YGN+GCNGGFM AFQYI+ GI+ ++ YPY AMD CQY + C YT++ G E+ L E +A GP+SVG+DA +PSF Y G+Y E SC+ ++HGVL VGYG + +G++YWLVKNSWG ++G GYI+M+++K N CGIA+ SYP +
Sbjct: 24 LDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLR-VPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQN-VNHGVLVVGYG--DLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI 331
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333]) HSP 1 Score: 285.804 bits (730), Expect = 7.828e-94 Identity = 142/307 (46.25%), Postives = 193/307 (62.87%), Query Frame = 1
Query: 160 ELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKS-VERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
E W +YK F+K Y E E + + +N+ I+ HN ++ LGR + +G+N DL ++ + R S ++ S ++++P+ V+W VT VKNQ CGSCWAFS TG++EGQ+ +K +LVS SEQ LVDCS YGN GCNGG MDQAF+YI G++ E YPY D C ++K+ V K Y D +G EE L +AT GPIS+ IDA + SFQ Y G+Y +E CSS +LDHGVL VGYG D + G+ YW+VKNSWG WG GYI++++++NN CG+AT ASYP
Sbjct: 30 EKWDDYKEDFDKEYSESEEQTYMEAFVKNMIHIENHNRDHRLGRKTFEMGLNHIADLPFSQYRKLNGYRRLFGDSRIKNSSSFLAPFNVQVPDEVDWRDTHLVTDVKNQGMCGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGD-YWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYP 335
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333]) HSP 1 Score: 233.417 bits (594), Expect = 2.114e-75 Identity = 110/196 (56.12%), Postives = 138/196 (70.41%), Query Frame = 1
Query: 490 CGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
CGSCWAFS TG++EGQ+ +K +LVS SEQ LVDCS YGN GCNGG MDQAF+YI G++ E YPY D C ++K+ V K Y D +G EE L +AT GPIS+ IDA + SFQ Y G+Y +E CSS +LDHGVL VGYG D + G+ YW+VKNSWG WG GYI++++++NN CG+AT ASYP
Sbjct: 2 CGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGD-YWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYP 196
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333]) HSP 1 Score: 233.417 bits (594), Expect = 2.114e-75 Identity = 110/196 (56.12%), Postives = 138/196 (70.41%), Query Frame = 1
Query: 490 CGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
CGSCWAFS TG++EGQ+ +K +LVS SEQ LVDCS YGN GCNGG MDQAF+YI G++ E YPY D C ++K+ V K Y D +G EE L +AT GPIS+ IDA + SFQ Y G+Y +E CSS +LDHGVL VGYG D + G+ YW+VKNSWG WG GYI++++++NN CG+AT ASYP
Sbjct: 2 CGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGD-YWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYP 196
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: tag-196 (pep chromosome:WBcel235:V:8594914:8597500:1 gene:WBGene00007055.1 transcript:F41E6.6.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-196) HSP 1 Score: 181.8 bits (460), Expect = 2.887e-52 Identity = 104/262 (39.69%), Postives = 152/262 (58.02%), Query Frame = 1
Query: 307 GVNQFTDLSHQEFLDIYMKYR--PIVKSVERKSFDKKRKSLK---LPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKF-GIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEES--CSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMAS 1068
G +F+D++ EF I + Y+ V +E+ +F+K ++ LP S +W +KG VT VKNQ CGSCWAFSTTG++EG +F KLVS SEQ+LVDC ++GCNGG A++ I++ G+E E YPY C ++ + ++ E ++ + L T GPIS+G++A+ + Q Y G+ C L+HGVL VGYG +D + YW+VKNSWG +WG GY K+ + K N CG+ MA+
Sbjct: 219 GFTKFSDMTTMEFKKIMLPYQWEQPVYPMEQANFEKHDVTINEEDLPESFDWREKGAVTQVKNQGNCGSCWAFSTTGNVEGAWFIAKNKLVSLSEQELVDCDSM--DQGCNGGLPSNAYKEIIRMGGLEPEDAYPYDGRGETCHLVRKDIAVYINGSVELPH-DEVEMQKWLVTKGPISIGLNAN--TLQFYRHGVVHPFKIFCEPFMLNHGVLIVGYG--KDGRKPYWIVKNSWGPNWGEAGYFKLYRGK-NVCGVQEMAT 472
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: tag-196 (pep chromosome:WBcel235:V:8594914:8597469:1 gene:WBGene00007055.1 transcript:F41E6.6.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-196) HSP 1 Score: 181.8 bits (460), Expect = 2.887e-52 Identity = 104/262 (39.69%), Postives = 152/262 (58.02%), Query Frame = 1
Query: 307 GVNQFTDLSHQEFLDIYMKYR--PIVKSVERKSFDKKRKSLK---LPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKF-GIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEES--CSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMAS 1068
G +F+D++ EF I + Y+ V +E+ +F+K ++ LP S +W +KG VT VKNQ CGSCWAFSTTG++EG +F KLVS SEQ+LVDC ++GCNGG A++ I++ G+E E YPY C ++ + ++ E ++ + L T GPIS+G++A+ + Q Y G+ C L+HGVL VGYG +D + YW+VKNSWG +WG GY K+ + K N CG+ MA+
Sbjct: 219 GFTKFSDMTTMEFKKIMLPYQWEQPVYPMEQANFEKHDVTINEEDLPESFDWREKGAVTQVKNQGNCGSCWAFSTTGNVEGAWFIAKNKLVSLSEQELVDCDSM--DQGCNGGLPSNAYKEIIRMGGLEPEDAYPYDGRGETCHLVRKDIAVYINGSVELPH-DEVEMQKWLVTKGPISIGLNAN--TLQFYRHGVVHPFKIFCEPFMLNHGVLIVGYG--KDGRKPYWIVKNSWGPNWGEAGYFKLYRGK-NVCGVQEMAT 472
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0087593) HSP 1 Score: 306.22 bits (783), Expect = 2.606e-101 Identity = 157/315 (49.84%), Postives = 205/315 (65.08%), Query Frame = 1
Query: 160 ELWSEYKTKFNKVY-DEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDI--------YMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
E W +K + K Y DE E R +I+ EN I KHN + G+ + L VN++ DL H EF + + + R +S + +F + LP SV+W KG VT VK+Q CGSCWAFS+TG++EGQ+F+K+ LVS SEQ LVDCS YGN GCNGG MD AF+YI GI+ E YPY A+D +C ++K V + +TDI QG E+ +AE +ATVGP+SV IDAS+ SFQ Y+ G+Y+E C + LDHGVL VG+G DE SGE YWLVKNSWG +WG G+IKM ++K NQCGIA+ +SYP
Sbjct: 57 EEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISP-AHVTLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDE-SGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYP 369
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0087592) HSP 1 Score: 304.679 bits (779), Expect = 3.655e-101 Identity = 157/315 (49.84%), Postives = 205/315 (65.08%), Query Frame = 1
Query: 160 ELWSEYKTKFNKVY-DEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDI--------YMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
E W +K + K Y DE E R +I+ EN I KHN + G+ + L VN++ DL H EF + + + R +S + +F + LP SV+W KG VT VK+Q CGSCWAFS+TG++EGQ+F+K+ LVS SEQ LVDCS YGN GCNGG MD AF+YI GI+ E YPY A+D +C ++K V + +TDI QG E+ +AE +ATVGP+SV IDAS+ SFQ Y+ G+Y+E C + LDHGVL VG+G DE SGE YWLVKNSWG +WG G+IKM ++K NQCGIA+ +SYP
Sbjct: 27 EEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISP-AHVTLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDE-SGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYP 339
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0339955) HSP 1 Score: 302.368 bits (773), Expect = 2.750e-100 Identity = 158/333 (47.45%), Postives = 210/333 (63.06%), Query Frame = 1
Query: 103 VPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDI--------YMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
+ C + + GI Q L E++ + DE E R +I+ EN I KHN + G+ + L VN++ DL H EF + + + R +S + +F + LP SV+W KG VT VK+Q CGSCWAFS+TG++EGQ+F+K+ LVS SEQ LVDCS YGN GCNGG MD AF+YI GI+ E YPY A+D +C ++K V + +TDI QG E+ +AE +ATVGP+SV IDAS+ SFQ Y+ G+Y+E C + LDHGVL VG+G DE SGE YWLVKNSWG +WG G+IKM ++K NQCGIA+ +SYP
Sbjct: 10 LDCSVQCAKYPGIL-QNLLRLVLEHRKNYQ---DETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISP-AHVTLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDE-SGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYP 336
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0304021) HSP 1 Score: 270.396 bits (690), Expect = 4.868e-89 Identity = 129/219 (58.90%), Postives = 162/219 (73.97%), Query Frame = 1
Query: 421 LKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
+ LP SV+W KG VT VK+Q CGSCWAFS+TG++EGQ+F+K+ LVS SEQ LVDCS YGN GCNGG MD AF+YI GI+ E YPY A+D +C ++K V + +TDI QG E+ +AE +ATVGP+SV IDAS+ SFQ Y+ G+Y+E C + LDHGVL VG+G DE SGE YWLVKNSWG +WG G+IKM ++K NQCGIA+ +SYP
Sbjct: 30 VTLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDE-SGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYP 247
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: CG6347 (gene:FBgn0033874 transcript:FBtr0087637) HSP 1 Score: 214.927 bits (546), Expect = 4.560e-66 Identity = 115/325 (35.38%), Postives = 182/325 (56.00%), Query Frame = 1
Query: 148 QGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKS-----FDKKR--KSLKLPNSVNWVKKGYVTPVKNQ-LQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKFGIEKESVYPYTAMDGNCQYSK------RKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL 1080
Q FD+ + + KVY +E R I+ + I N + G + LGVN D++ +E + I + ER + F R S LP +W +KG VTP Q + CG+CW+F+TTG++EG F++T L S S+Q LVDC+ YGN GC+GGF + F+YI G+ + YPYT + C+ ++ R+ + + ++Y I G EE + E +AT+GP++ ++A SF+ Y+GGIY++E C+ +L+H V VGYG ++G YW++KNS+ +WG G++++ ++ CGIA+ SYP L
Sbjct: 36 QNFDD----FLRQTGKVYSDEERVYRESIFAAKMSLITLSNKNADNGVSGFRLGVNTLADMTRKEIATLLGS--KISEFGERYTNGHINFVTARNPASANLPEMFDWREKGGVTPPGFQGVGCGACWSFATTGALEGHLFRRTGVLASLSQQNLVDCADDYGNMGCDGGFQEYGFEYIRDHGVTLANKYPYTQTEMQCRQNETAGRPPRESLVKIRDYATITPGDEEKMKEVIATLGPLACSMNADTISFEQYSGGIYEDEECNQGELNHSVTVVGYGT--ENGRDYWIIKNSYSQNWGEGGFMRILRNAGGFCGIASECSYPIL 352
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: si:dkey-269i1.4 (si:dkey-269i1.4 [Source:ZFIN;Acc:ZDB-GENE-121214-37]) HSP 1 Score: 332.028 bits (850), Expect = 7.807e-112 Identity = 162/335 (48.36%), Postives = 219/335 (65.37%), Query Frame = 1
Query: 82 IRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKF-GIEKESVYPYTAMDG-NCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
+ LL+ C + S I Q D+ W+ +K++ K Y E+ E RR IWEENL+ I++HN EY+ G H + +G+NQF D++++EF Y+ + + P V+W ++GYVTPVK+Q QCGSCW+FS+TG++EGQ F+KT KL+S SEQ LVDCS+ +GN+GCNGG MDQAFQY+ + G++ E YPY A D C+Y R + + + DI +G+E L +A VGP+SV IDAS+ S Q Y GIY E +CSS++LDH VL VGYG + +G +YW+VKNSW D WG GYI M+KDKNN CGIATMASYP
Sbjct: 1 MMFALLVTLCISAVFAASSIDIQ-LDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSYGNHTFKMGMNQFGDMTNEEFRHAMNGYKHDPNQTSQGPLFMEPSFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPHGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPKGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACSSSRLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYP 334
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: si:dkey-239j18.2 (si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-52]) HSP 1 Score: 328.176 bits (840), Expect = 2.883e-110 Identity = 166/339 (48.97%), Postives = 221/339 (65.19%), Query Frame = 1
Query: 70 MMHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKF-GIEKESVYPYTAMDG-NCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
MM + + L I FA I Q D+ W+ +K++ K Y E+ E RR IWEENL+ I++HN EY+LG H + +G+NQF D++++EF Y+ + + K P V+W ++GYVTPVK+Q QCGSCW+FS+TG++EGQ F+KT KL+S SEQ LVDCS+ +GN+GCNGG MDQAFQY+ + G++ E YPY A D C+Y R + + + DI +G+E L +A VGP+SV IDAS+ S Q Y GIY E +C+S QLDH VL VGYG + +G +YW+VKNSW D WG GYI M+KDKNN CGIATMASYP
Sbjct: 1 MMFALLVTLYISAVFAAP----SIDIQ-LDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSLGNHTFKMGMNQFGDMTNEEFRQAMNGYKHDPNRTSQGPLFMEPKFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPHGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPKGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACTS-QLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYP 333
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: si:dkey-239j18.2 (si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-52]) HSP 1 Score: 328.176 bits (840), Expect = 2.883e-110 Identity = 166/339 (48.97%), Postives = 221/339 (65.19%), Query Frame = 1
Query: 70 MMHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKF-GIEKESVYPYTAMDG-NCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
MM + + L I FA I Q D+ W+ +K++ K Y E+ E RR IWEENL+ I++HN EY+LG H + +G+NQF D++++EF Y+ + + K P V+W ++GYVTPVK+Q QCGSCW+FS+TG++EGQ F+KT KL+S SEQ LVDCS+ +GN+GCNGG MDQAFQY+ + G++ E YPY A D C+Y R + + + DI +G+E L +A VGP+SV IDAS+ S Q Y GIY E +C+S QLDH VL VGYG + +G +YW+VKNSW D WG GYI M+KDKNN CGIATMASYP
Sbjct: 1 MMFALLVTLYISAVFAAP----SIDIQ-LDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSLGNHTFKMGMNQFGDMTNEEFRQAMNGYKHDPNRTSQGPLFMEPKFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPHGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPKGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACTS-QLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYP 333
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: si:dkey-269i1.4 (si:dkey-269i1.4 [Source:ZFIN;Acc:ZDB-GENE-121214-37]) HSP 1 Score: 327.405 bits (838), Expect = 4.913e-110 Identity = 160/335 (47.76%), Postives = 217/335 (64.78%), Query Frame = 1
Query: 82 IRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKF-GIEKESVYPYTAMDG-NCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
+ LL+ C + S I Q D+ W+ +K++ K Y E+ E RR IWEENL+ I++HN EY+ G H + +G+NQF D++++EF Y+ + + P V+W ++GYVTPVK+Q QCGSCW+FS+TG++EGQ F+KT KL+S SEQ LVDCS+ GN+GCNGG MDQAFQY+ + G++ E YPY A D C+Y R + + + DI +G+E L +A VGP+SV IDAS+ S Q Y GIY E +CSS++LDH VL VGYG + +G +YW+VKNSW D WG GYI M+KDKNN CG+AT ASYP
Sbjct: 1 MMFALLVTLCISAVFAASSIDIQ-LDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLKKIEQHNFEYSYGNHTFKMGMNQFGDMTNEEFRQAMNGYKHDPNRTSQGPLFMEPSFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPQGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPRGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACSSSRLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGVATTASYP 334
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctslb (cathepsin Lb [Source:ZFIN;Acc:ZDB-GENE-980526-285]) HSP 1 Score: 327.02 bits (837), Expect = 7.110e-110 Identity = 160/335 (47.76%), Postives = 217/335 (64.78%), Query Frame = 1
Query: 82 IRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKF-GIEKESVYPYTAMDG-NCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
+ LL+ C + S I Q D+ W+ +K++ K Y E+ E RR IWEENL+ I++HN EY+ G H + +G+NQF D++++EF Y+ + + P V+W ++GYVTPVK+Q QCGSCW+FS+TG++EGQ F+KT KL+S SEQ LVDCS+ GN+GCNGG MDQAFQY+ + G++ E YPY A D C+Y R + + + DI +G+E L +A VGP+SV IDAS+ S Q Y GIY E +CSS++LDH VL VGYG + +G +YW+VKNSW D WG GYI M+KDKNN CG+AT ASYP
Sbjct: 1 MMFALLVTLCISAVFAASSIDIQ-LDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSYGNHTFKMGMNQFGDMTNEEFRQAMNGYKHDPNRTSQGPLFMEPSFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPQGNQGCNGGIMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPRGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACSSSRLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGVATSASYP 334
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: fcrl2 (Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-5904272]) HSP 1 Score: 317.005 bits (811), Expect = 8.639e-106 Identity = 160/313 (51.12%), Postives = 212/313 (67.73%), Query Frame = 1
Query: 151 GFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGN-CQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGV---DEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
D W+ +K K Y + E RR +WE+NL+ I+ HN+E++LG+H ++LG+NQF D++++EF + Y+ K R S + + P SV+W KKGYVTPVK+Q QCGSCWAFSTTG++EGQ+++ T K++S SEQ LVDCS++ GN+GCNGG MDQAFQY+ GI+ E YPYTA D C Y + D+ GSE+DL +A+VGP+SV +DA + SFQ Y GIY E CSS LDHGVL VGYG DED G+KYW+VKNSW + WG +GYI ++KD++N CGIAT ASYP
Sbjct: 24 ALDNHWNLWKNWHKKSYAPKEEGWRRVLWEKNLRMIEFHNLEHSLGKHSHSLGMNQFGDMTNEEFRQLMNGYKNQKKI--RGSTFLAPNNFESPKSVDWRKKGYVTPVKDQGQCGSCWAFSTTGALEGQHYRNTGKMISLSEQNLVDCSRAQGNQGCNGGLMDQAFQYVKDNGGIDSEDSYPYTAKDDQECHYDPNYNSANDTGFVDVTSGSEKDLMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDED-GKKYWIVKNSWSEKWGNDGYIYIAKDRHNHCGIATAASYP 333
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: fcrl2 (Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-5904272]) HSP 1 Score: 317.005 bits (811), Expect = 1.365e-105 Identity = 163/338 (48.22%), Postives = 220/338 (65.09%), Query Frame = 1
Query: 76 HFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGN-CQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGV---DEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
+ + + L I T+ + D W+ +K K Y + E RR +WE+NL+ I+ HN+E++LG+H ++LG+NQF D++++EF + Y+ K R S + + P SV+W KKGYVTPVK+Q QCGSCWAFSTTG++EGQ+++ T K++S SEQ LVDCS++ GN+GCNGG MDQAFQY+ GI+ E YPYTA D C Y + D+ GSE+DL +A+VGP+SV +DA + SFQ Y GIY E CSS LDHGVL VGYG DED G+KYW+VKNSW + WG +GYI ++KD++N CGIAT ASYP
Sbjct: 6 YIMALYLGIAAICLTTVFAAPTTDPALDNHWNLWKNWHKKSYAPKEEGWRRVLWEKNLRMIEFHNLEHSLGKHSHSLGMNQFGDMTNEEFRQLMNGYKNQKKI--RGSTFLAPNNFESPKSVDWRKKGYVTPVKDQGQCGSCWAFSTTGALEGQHYRNTGKMISLSEQNLVDCSRAQGNQGCNGGLMDQAFQYVKDNGGIDSEDSYPYTAKDDQECHYDPNYNSANDTGFVDVTSGSEKDLMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDED-GKKYWIVKNSWSEKWGNDGYIYIAKDRHNHCGIATAASYP 340
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: ano1 (anoctamin 1, calcium activated chloride channel [Source:Xenbase;Acc:XB-GENE-5967576]) HSP 1 Score: 286.574 bits (732), Expect = 7.750e-94 Identity = 140/315 (44.44%), Postives = 201/315 (63.81%), Query Frame = 1
Query: 151 GFDELWSEYKTKFNKVYDEENEFVRRQI-WEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSL---KLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL 1080
D W +K NK Y++E E ++R+I WE+NL + HN+EY++G H Y LG+N D++ +E +S + +F ++ S K+P+S++W KG V+ VKNQ CGSCWAFS G++EGQ KT KLVS S Q LVDCS YGN+GC GGFM QAFQY++ GI+ +S YPY AMD C Y + C YT+I G+E++L + L ++GPISV ID + PSF Y G+Y + +CS +++HGVLAVGYG +G+ +WL+KNSWG +G GY++++++K N CG+A+ YP +
Sbjct: 22 ALDNHWLLWKNTHNKDYEDEIEDLQRRITWEKNLNLVNMHNLEYSMGMHTYELGMNHLADMTSEEIKSKLTGLILPPQSERQATFSSQKNSTFGGKVPDSIDWRDKGCVSDVKNQGGCGSCWAFSAVGALEGQLMLKTGKLVSLSPQNLVDCSSKYGNKGCGGGFMTQAFQYVIDNKGIDSDSYYPYHAMDEKCHYDPTGKASTCAKYTEIVPGTEDNLKQALGSIGPISVAIDGTRPSFFLYRSGVYSDPTCSH-EVNHGVLAVGYG--NLNGQDFWLLKNSWGTKYGDQGYVRIARNKGNLCGVASYTCYPEI 333
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: harbi1 (harbinger transposase derived 1 [Source:Xenbase;Acc:XB-GENE-6077433]) HSP 1 Score: 283.493 bits (724), Expect = 1.242e-92 Identity = 143/317 (45.11%), Postives = 203/317 (64.04%), Query Frame = 1
Query: 139 IFFQG-FDELWSEYKTKFNKVYDEE-NEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIY--MKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKF-GIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
+++ G D W +KT ++K YD + +E +RR IWE+NL I+ HN+E+ G H Y LG+N+F D++ +E + + +K + S D+ S ++PNS+++ KKGYVTP+++Q +CGSCWAFST G++EGQ KKT KLV S Q LVDC + N GC GG+M AF+Y+ K GI+ E YPY MD C+Y+ K + ++ +GSE L + + VGPISVGIDA +F Y GIY ++SC ++H VLAVGYG + KYW++KNSWG+ WG GYI M+++K N CGIA +ASYP
Sbjct: 18 LYYNGTLDSEWEIWKTTYHKHYDNKIHELMRRLIWEKNLNIIRSHNLEFTQGLHTYELGMNKFGDMTSEEVVRMMTGLKVHTGMGPTNLTS-DEDEASQRIPNSIDYRKKGYVTPIRDQGECGSCWAFSTVGALEGQLMKKTGKLVGISPQNLVDCVKD--NFGCGGGYMTTAFKYVKKNKGIDSEEAYPYVGMDQKCKYNVSGRAAEIKGFKEVKKGSETALKKAVGLVGPISVGIDAGLDTFFLYKKGIYYDKSCDGDSINHAVLAVGYGKQKKG--KYWIIKNSWGEDWGNKGYILMAREKGNACGIANLASYP 329
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: ctsk (cathepsin K (pycnodysostosis) [Source:NCBI gene;Acc:448216]) HSP 1 Score: 271.166 bits (692), Expect = 8.122e-88 Identity = 136/309 (44.01%), Postives = 190/309 (61.49%), Query Frame = 1
Query: 154 FDELWSEYKTKFNKVYDEE-NEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
D W +K +++ Y+ + +E RRQIWE+NL I +HN E++ G H Y L +N D++ +E + M + ++ + S ++P +++ KKGYVTPV NQ CGSCWAFS+ G++EGQ KKT KLVS S Q LVDC N GC GG+M AF Y+ GI+ ++ YPY D C Y+ CK Y +I GSE+ L +A VGP+SV IDAS PSFQ Y G+Y + SC+ ++H VL VGYG + G K+W++KNSWGD WG GY+ +++DK N CGIA++AS+P
Sbjct: 31 LDSKWELWKKTYHRQYNGQLDEIRRRQIWEKNLNLISQHNKEFSQGLHTYDLAMNHLGDMTSEEVVQKMMGLKVPPNHRPNNTYIPEWNS-RIPEYIDYRKKGYVTPVHNQGICGSCWAFSSVGALEGQLMKKTGKLVSLSPQNLVDCDTD--NYGCEGGYMTNAFGYVRDNGGIDSDAEYPYVGQDEGCHYNPADKAATCKGYKEIPVGSEKALKRAVANVGPVSVSIDASLPSFQFYKKGVYYDSSCNPDAVNHAVLVVGYG--NEKGIKHWIIKNSWGDWWGKKGYVLLARDKKNACGIASLASFP 334
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsl (cathepsin L [Source:MGI Symbol;Acc:MGI:88564]) HSP 1 Score: 317.39 bits (812), Expect = 4.282e-106 Identity = 158/314 (50.32%), Postives = 213/314 (67.83%), Query Frame = 1
Query: 142 FFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMK-FGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
F Q F W ++K+ ++Y E RR IWE+N++ IQ HN EY+ G+H +++ +N F D++++EF + YR + ++ ++ LK+P SV+W +KG VTPVKNQ QCGSCWAFS +G +EGQ F KT KL+S SEQ LVDCS + GN+GCNGG MD AFQYI + G++ E YPY A DG+C+Y + + DI Q E+ L + +ATVGPISV +DAS+PS Q Y+ GIY E +CSS LDHGVL VGYG + + + KYWLVKNSWG WG+ GYIK++KD++N CG+AT ASYP
Sbjct: 21 FDQTFSAEWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRH--QKHKKGRLFQEPLMLKIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYP 331
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsl (cathepsin L [Source:MGI Symbol;Acc:MGI:88564]) HSP 1 Score: 317.39 bits (812), Expect = 4.282e-106 Identity = 158/314 (50.32%), Postives = 213/314 (67.83%), Query Frame = 1
Query: 142 FFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMK-FGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
F Q F W ++K+ ++Y E RR IWE+N++ IQ HN EY+ G+H +++ +N F D++++EF + YR + ++ ++ LK+P SV+W +KG VTPVKNQ QCGSCWAFS +G +EGQ F KT KL+S SEQ LVDCS + GN+GCNGG MD AFQYI + G++ E YPY A DG+C+Y + + DI Q E+ L + +ATVGPISV +DAS+PS Q Y+ GIY E +CSS LDHGVL VGYG + + + KYWLVKNSWG WG+ GYIK++KD++N CG+AT ASYP
Sbjct: 21 FDQTFSAEWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRH--QKHKKGRLFQEPLMLKIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYP 331
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsll3 (cathepsin L-like 3 [Source:MGI Symbol;Acc:MGI:1917452]) HSP 1 Score: 306.605 bits (784), Expect = 7.758e-102 Identity = 158/330 (47.88%), Postives = 207/330 (62.73%), Query Frame = 1
Query: 88 IILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKFGIEKESV-YPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
+ LL C + + D +W E+KTK K Y+ +E +R +WE N + I HN +Y G+H ++L +N F DL++ EF ++ ++ + K F + +P SV+W GYVTPVK+Q CGSCWAFS GS+EGQ F+KT KLV S Q LVDCS S GN+GC+GG D AFQY+ G SV YPY A++G C+Y+ + + ++ Q SE+ L + +ATVGPISVGID + SFQ Y G+Y E CSST LDH VL VGYG +E G KYWLVKNSWG WG+NGYIKM+KD+NN CGIA+ ASYP
Sbjct: 4 VFLLATLCLG-VVSAAPAHNPSLDAVWEEWKTKHKKTYNMNDEGQKRAVWENNKKMIDLHNEDYLKGKHGFSLEMNAFGDLTNTEFRELMTGFQGQKTKMMMKVFQEPLLG-DVPKSVDWRDHGYVTPVKDQGSCGSCWAFSAVGSLEGQMFRKTGKLVPLSVQNLVDCSWSQGNQGCDGGLPDLAFQYVKDNGGLDTSVSYPYEALNGTCRYNPKNSAATVTGFVNV-QSSEDALMKAVATVGPISVGIDTKHKSFQFYKEGMYYEPDCSSTVLDHAVLVVGYG-EESDGRKYWLVKNSWGRDWGMNGYIKMAKDRNNNCGIASDASYP 329
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: BC051665 (cDNA sequence BC051665 [Source:MGI Symbol;Acc:MGI:2682300]) HSP 1 Score: 300.827 bits (769), Expect = 1.154e-99 Identity = 154/334 (46.11%), Postives = 206/334 (61.68%), Query Frame = 1
Query: 88 IILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSL--KLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMK-FGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL 1080
+ LL C + + D +W E+KTK K Y+ E +R +WE N++ I HN +Y G+H + L +N F DL++ EF ++ + +S+ K ++ L +P SV+W GYVTPVK+Q CGSCWAFS GS+EGQ F+KT KLV SEQ L+DCS SYGN GCNGG M+ AFQY+ + G++ Y Y A DG C+Y + + + SE+ L +A+VGP+SVGID + SF+ Y GG Y E CSST LDH VL VGYG +E G KYWLVKNSWG+ WG++GYIKM+KD++N CGIAT A YP +
Sbjct: 4 VFLLATLCLG-VVSAAPAHDPSLDAVWEEWKTKHRKTYNMNEEAQKRAVWENNMKMIGLHNEDYLKGKHGFNLEMNAFGDLTNTEFRELMTGF----QSMGHKEMTIFQEPLLGDVPKSVDWRDHGYVTPVKDQGHCGSCWAFSAVGSLEGQIFRKTGKLVPLSEQNLMDCSWSYGNVGCNGGLMELAFQYVKENRGLDTRESYAYEAWDGPCRYDPKYSAVNITGFVKVPL-SEDALMNAVASVGPVSVGIDTHHHSFRFYRGGTYYEPDCSSTNLDHAVLVVGYG-EESDGRKYWLVKNSWGEDWGMDGYIKMAKDRDNNCGIATYAIYPTV 330
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: 4930486L24Rik (RIKEN cDNA 4930486L24 gene [Source:MGI Symbol;Acc:MGI:1922258]) HSP 1 Score: 290.812 bits (743), Expect = 1.352e-95 Identity = 150/335 (44.78%), Postives = 202/335 (60.30%), Query Frame = 1
Query: 79 FIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGV--DEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
F+ I+ L + A T+ S D W+E++TK K Y+ E +RR +WE+N + I+ HN EY G+H +T+ +N F DL++ EF+ + +R + ++R + + L +P V+W GYVTPVKNQ C S WAFS TGS+EGQ FKKT +LV SEQ L+DC S C+GGFM AFQY+ G+ E YPY C+Y +++ I G EE L + +A VGPISV +DAS+ SFQ Y+ GIY E C L+H VL VGYG +E G YWLVKNSWG+ WG+ GYIK++KD NN CGIAT+A+YP
Sbjct: 6 FLAILCLEIDSTAPTLDPS------LDVQWNEWRTKHGKAYNVNEERLRRAVWEKNFKMIELHNWEYLEGKHDFTMTMNAFGDLTNTEFVKMMTGFRR--QKIKRMHVFQDHQFLYVPKYVDWRMLGYVTPVKNQGYCASSWAFSATGSLEGQMFKKTGRLVPLSEQNLLDCMGSNVTHDCSGGFMQNAFQYVKDNGGLATEESYPYIGPGRKCRYHAENSAANVRDFVQI-PGREEALMKAVAKVGPISVAVDASHDSFQFYDSGIYYEPQCKRVHLNHAVLVVGYGFEGEESDGNSYWLVKNSWGEEWGMKGYIKIAKDWNNHCGIATLATYP 331
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|O60911|CATL2_HUMAN (Cathepsin L2 OS=Homo sapiens OX=9606 GN=CTSV PE=1 SV=2) HSP 1 Score: 328.176 bits (840), Expect = 1.694e-109 Identity = 163/339 (48.08%), Postives = 218/339 (64.31%), Query Frame = 1
Query: 73 MHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMK-FGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL 1080
M+ ++ A +P F Q D W ++K ++Y E RR +WE+N++ I+ HN EY+ G+H +T+ +N F D++++EF + +R + + ++ L LP SV+W KKGYVTPVKNQ QCGSCWAFS TG++EGQ F+KT KLVS SEQ LVDCS+ GN+GCNGGFM +AFQY+ + G++ E YPY A+D C+Y + +T + G E+ L + +ATVGPISV +DA + SFQ Y GIY E CSS LDHGVL VGYG + + KYWLVKNSWG WG NGY+K++KDKNN CGIAT ASYPN+
Sbjct: 1 MNLSLVLAAFCLGIASAVP---KFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRN--QKFRKGKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|P07154|CATL1_RAT (Cathepsin L1 OS=Rattus norvegicus OX=10116 GN=Ctsl PE=1 SV=2) HSP 1 Score: 320.857 bits (821), Expect = 1.739e-106 Identity = 158/314 (50.32%), Postives = 215/314 (68.47%), Query Frame = 1
Query: 142 FFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMK-FGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
F Q F+ W ++K+ ++Y E RR +WE+N++ IQ HN EY+ G+H +T+ +N F D++++EF I YR + ++ ++ L++P +V+W +KG VTPVKNQ QCGSCWAFS +G +EGQ F KT KL+S SEQ LVDCS GN+GCNGG MD AFQYI + G++ E YPY A DG+C+Y + + DI Q E+ L + +ATVGPISV +DAS+PS Q Y+ GIY E +CSS LDHGVL VGYG + + + +KYWLVKNSWG WG++GYIK++KD+NN CG+AT ASYP
Sbjct: 21 FDQTFNAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTNEEFRQIVNGYRH--QKHKKGRLFQEPLMLQIPKTVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVVGYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYP 331
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|P06797|CATL1_MOUSE (Cathepsin L1 OS=Mus musculus OX=10090 GN=Ctsl PE=1 SV=2) HSP 1 Score: 317.39 bits (812), Expect = 2.995e-105 Identity = 158/314 (50.32%), Postives = 213/314 (67.83%), Query Frame = 1
Query: 142 FFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMK-FGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
F Q F W ++K+ ++Y E RR IWE+N++ IQ HN EY+ G+H +++ +N F D++++EF + YR + ++ ++ LK+P SV+W +KG VTPVKNQ QCGSCWAFS +G +EGQ F KT KL+S SEQ LVDCS + GN+GCNGG MD AFQYI + G++ E YPY A DG+C+Y + + DI Q E+ L + +ATVGPISV +DAS+PS Q Y+ GIY E +CSS LDHGVL VGYG + + + KYWLVKNSWG WG+ GYIK++KD++N CG+AT ASYP
Sbjct: 21 FDQTFSAEWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRH--QKHKKGRLFQEPLMLKIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYP 331
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|Q9GKL8|CATL1_CHLAE (Cathepsin L1 OS=Chlorocebus aethiops OX=9534 GN=CTSL PE=1 SV=1) HSP 1 Score: 309.686 bits (792), Expect = 3.228e-102 Identity = 155/316 (49.05%), Postives = 208/316 (65.82%), Query Frame = 1
Query: 142 FFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL 1080
F + W+++K N++Y E RR +WE+N++ I+ HN EY+ G+H +T+ +N F D++ +EF + ++ K + K F ++ + P SV+W +KGYVTPVKNQ QCGSCWAFS TG++EGQ F+KT KLVS SEQ LVDCS GNEGCNGG MD AFQY+ G++ E YPY A + +C+Y+ + + DI + E+ L + +ATVGPISV IDA + SF Y GIY E CSS +DHGVL VGYG + E KYWLVKNSWG+ WG+ GYIKM+KD+ N CGIA+ ASYP +
Sbjct: 21 FNHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHSFTMAMNTFGDMTSEEFRQVMNGFQN-RKPRKGKVF-QEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVADNGGLDSEESYPYEATEESCKYNPEYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFMFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNSKYWLVKNSWGEEWGMGGYIKMAKDRRNHCGIASAASYPTV 333
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|P07711|CATL1_HUMAN (Cathepsin L1 OS=Homo sapiens OX=9606 GN=CTSL PE=1 SV=2) HSP 1 Score: 308.916 bits (790), Expect = 6.680e-102 Identity = 156/332 (46.99%), Postives = 215/332 (64.76%), Query Frame = 1
Query: 97 LIVPCFAETIPWSGIFF-QGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL 1080
LI+ F I + + F + W+++K N++Y E RR +WE+N++ I+ HN EY G+H +T+ +N F D++ +EF + ++ K + K F ++ + P SV+W +KGYVTPVKNQ QCGSCWAFS TG++EGQ F+KT +L+S SEQ LVDCS GNEGCNGG MD AFQY+ G++ E YPY A + +C+Y+ + + + DI + E+ L + +ATVGPISV IDA + SF Y GIY E CSS +DHGVL VGYG + E KYWLVKNSWG+ WG+ GY+KM+KD+ N CGIA+ ASYP +
Sbjct: 5 LILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQN-RKPRKGKVF-QEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A2U8U447 (Cathepsin L2 OS=Dugesia japonica OX=6161 PE=2 SV=1) HSP 1 Score: 394.815 bits (1013), Expect = 3.796e-133 Identity = 191/333 (57.36%), Postives = 234/333 (70.27%), Query Frame = 1
Query: 82 IRIILL--IVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
++IILL I + +P ++ W YK KF+K Y+ NE RR IWE NL+FIQ+HN+EY+LG+H Y LG+N+F D++H+EF Y+ +PI ++ F LP ++W KGYVTPVKNQ QCGSCWAFSTTGS+EGQ+F+K+ KLVSFSEQQLVDCS+S+ N GCNGG MD AF YI KFGIE E YPY A DG C Y K K++ C + DI G+E DL +AT GPISV IDASN SFQ Y GGIY+E CSS LDHGVLA+GYG ++ E YW+VKNSW SWG++GYI+MSKDK NQCGIATMASYP
Sbjct: 1 MKIILLTSIFLVTIQAVPHKFTINSELNDEWEVYKMKFSKKYETLNEISRRIIWENNLKFIQQHNVEYDLGKHTYYLGLNEFADMTHEEFKAKYLGLKPINRNFTSSRFIIPENIGDLPTRIDWRTKGYVTPVKNQGQCGSCWAFSTTGSLEGQHFRKSGKLVSFSEQQLVDCSRSFDNLGCNGGLMDNAFSYIQKFGIENEISYPYVANDGVCAYDKTKIVGTCTGFVDIKTGNETDLMAAVATQGPISVAIDASNDSFQFYRGGIYNEPHCSSKDLDHGVLAIGYG--SENNENYWIVKNSWDISWGMSGYIRMSKDKMNQCGIATMASYP 331
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A0B5ITX6 (Cathepsin L3 OS=Nephilengys cruentata OX=450950 PE=2 SV=1) HSP 1 Score: 364.385 bits (934), Expect = 3.041e-121 Identity = 179/337 (53.12%), Postives = 231/337 (68.55%), Query Frame = 1
Query: 70 MMHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKS-LKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMK-FGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
M I L V A +P F +D+ W +KTKFNK Y++ EF RR +WE NL+ + KHNIEY LG +Y G+N+++D++HQEF+ + V S + + R S + LP++V+W K G VTP+KNQ QCGSCWAFSTTGS+EGQ+ KKT KLVS SEQ LVDCSQ GN+GC GG MDQ F+YI + GI+ E+ YPY A+D C++ ++ V C Y D+ G E+ L + +AT+GPISV IDAS SFQ Y GG+Y EE+CS+ +LDHGVL VGYG ++ GE YWLVKNSWG SWG+ GYI M+++KNNQCGIAT ASYP
Sbjct: 1 MKAIALICCLFVVIAARKLP----FNPDYDQHWEVFKTKFNKNYEKNEEFARRLVWEVNLEAVIKHNIEYELGMQRYRKGINEYSDMTHQEFVRRMNGLKKGVNSTTKSVYTFDRLSNVVLPDTVDWRKDGMVTPIKNQQQCGSCWAFSTTGSLEGQHKKKTGKLVSLSEQNLVDCSQKQGNDGCEGGLMDQGFEYIKENNGIDTEASYPYEAIDDKCRFKRQSVGATCTGYVDVKSGDEDALKQAVATIGPISVAIDASQFSFQLYRGGVYYEENCSTEELDHGVLVVGYGTTQN-GEDYWLVKNSWGTSWGIKGYIMMARNKNNQCGIATQASYP 332
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A0L8HPF9 (Uncharacterized protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22009826mg PE=3 SV=1) HSP 1 Score: 363.229 bits (931), Expect = 9.040e-121 Identity = 181/338 (53.55%), Postives = 228/338 (67.46%), Query Frame = 1
Query: 73 MHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYD-EENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLK-LPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL 1080
M + +LL V C A ++P S F D+ W Y FNK Y+ ENEFVRR IWE+NLQ++ +HN+E ++G H Y LG+N++ DL ++EF+ P + + ++K LP++V+W KGYVT VKNQ QCGSCWAFSTTGS+EGQ FKKT KLVS SEQ LVDCS S+GN GC GG MD AF+YI KFGI+ E+ YPY D C+Y K V+ Y D+ SE+ L +A VGPISV IDA + SFQ Y G+Y E CS+T LDHGVLAVGYG D+G+ YWLVKNSWG SWG+ GYIKM++++NN CGIAT ASYP +
Sbjct: 3 MKSLVAVLLFVAC-AASVPLSDNFL---DQSWQTYMKLFNKKYNTAENEFVRRVIWEKNLQYVNQHNLEADMGLHTYWLGLNEYADLENREFVQRMNNLIPRNLTTYKPKLIFANDNIKDLPDTVDWRTKGYVTEVKNQAQCGSCWAFSTTGSLEGQIFKKTGKLVSLSEQNLVDCSGSFGNNGCEGGLMDNAFKYIKKFGIDSEASYPYEGRDAKCRYKKSDVVATDTGYVDVKSMSEDSLQSAVAKVGPISVAIDAGHLSFQLYKHGVYKESRCSATALDHGVLAVGYGT--DNGQDYWLVKNSWGGSWGVKGYIKMARNQNNMCGIATQASYPTV 334
BLAST of Cathepsin L2 vs. TrEMBL
Match: W4YG81 (Uncharacterized protein OS=Strongylocentrotus purpuratus OX=7668 PE=3 SV=1) HSP 1 Score: 357.451 bits (916), Expect = 1.706e-118 Identity = 176/332 (53.01%), Postives = 227/332 (68.37%), Query Frame = 1
Query: 91 ILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVY-DEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYR--PIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKF-GIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
+LL+ C ++ S F FDE W+++K + K Y +E E R+ IWE+NL + KHN++Y+LG Y LG+NQF DL ++EF+ + +R K+ + +F +LP +V+W KGYVTPVK+Q QCGSCWAFSTTGS+EGQ+FK T KLVS SEQ LVDCS GNEGC+GG MDQAFQYI+K GI+ E YPY A+DG C + K + YTD+ SE L + +A +GPISV IDAS+ SFQ Y G+Y+E CSST LDHGVLAVGYG D G YW+VKNSW ++WG+NGY+ MS++K+NQCGIAT ASYP
Sbjct: 6 VLLVAACVVSSLSMS---FTDFDEDWNQWKNEHGKRYLSDEEEASRKLIWEKNLDIVIKHNLKYDLGHFTYALGMNQFADLKNEEFVAMMTGFRVNGTSKAAKGSTFLPSNNIGELPKTVDWRTKGYVTPVKDQGQCGSCWAFSTTGSLEGQHFKATGKLVSLSEQNLVDCSGKEGNEGCDGGLMDQAFQYIIKAGGIDTEESYPYKAVDGECHFKKANIGATVTGYTDVTSDSETALQKAVAHIGPISVAIDASHMSFQLYKSGVYNEPDCSSTLLDHGVLAVGYGTTSD-GTDYWIVKNSWAETWGMNGYLWMSRNKDNQCGIATQASYP 333
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A4Y2RKW0 (Cathepsin L OS=Araneus ventricosus OX=182803 GN=CATL_10 PE=3 SV=1) HSP 1 Score: 355.14 bits (910), Expect = 1.618e-117 Identity = 177/335 (52.84%), Postives = 220/335 (65.67%), Query Frame = 1
Query: 73 MHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYI-MKFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
M F+ + L V + I +E W +K F KVYDE E RR IWE+ + + +HN+ Y+LG H Y G+N+++D+ H+EF+ I+ +R S + ++P+ V+W KG VTPVKNQ QCGSCWAFSTTGS+EGQ+ KKT +LVS SEQ LVDCS GNEGC GG MDQAF+Y+ + GI+ E YPYTA DG C + K V Y DI G EE L + +AT+GPISV IDAS+ SFQ+Y GIYDE CSS LDHGVLAVGYG ++ G YWLVKNSWG SWG+ GYIKMS++KNNQCGIAT ASYP
Sbjct: 1 MKFLALFALFVVAASRHIQLD----PKLNEHWENFKKVFGKVYDETEEVSRRMIWEQRVSDVVRHNLRYDLGLHSYRKGINEYSDMEHEEFVRIFNGFRRQPGQKTNASTWVPVFNAQIPDQVDWRTKGLVTPVKNQQQCGSCWAFSTTGSLEGQHKKKTGQLVSLSEQNLVDCSGPEGNEGCGGGLMDQAFEYVKVNKGIDTEKSYPYTAEDGTCHFKKSSVGATVTGYVDIPSGDEEALKQAVATIGPISVAIDASSDSFQTYQDGIYDEPECSSVFLDHGVLAVGYGTED--GSDYWLVKNSWGTSWGIKGYIKMSRNKNNQCGIATQASYP 329
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: si:dkey-26g8.5 (cathepsin L1-like [Source:NCBI gene;Acc:103028700]) HSP 1 Score: 327.791 bits (839), Expect = 3.211e-110 Identity = 165/337 (48.96%), Postives = 222/337 (65.88%), Query Frame = 1
Query: 79 FIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGN-CQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGY---GVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
F+ + L+ CF + Q D+ W +K+ +K Y E+ E RR +WE+NL+ ++ HN+E+++G+H Y LG+NQF D++++EF YR + S + L++P V+W +KGYVTPVK+Q +CGSCWAFS+TG++EGQ+F+KT KLVS SEQ LVDCS+ GN+GCNGG M+QAFQY+ GI+ E YPYTA D C+Y + DI G E L + +A VGP+SV IDA + SFQ Y GIY E++CSS +LDHGVL VGY G DED G+KYW+VKNSW + WG NGYI M+KD+ N CGIA+ ASYP
Sbjct: 2 FLTLASLLALCFCTGFTAPSLDRQ-LDDHWKLWKSWHSKSYHEKEEGWRRLVWEKNLKKVELHNLEHSMGKHTYRLGMNQFADMTNEEFRQAMNGYRSNPNKKSKGSLFLEPSFLEVPKQVDWREKGYVTPVKDQARCGSCWAFSSTGALEGQHFRKTGKLVSLSEQNLVDCSRPEGNQGCNGGIMEQAFQYVKDNGGIDSEESYPYTAKDDQPCRYDPNFNSANDTGFVDIPSGEEHALMKAVAAVGPVSVAIDAGHESFQFYQSGIYYEKACSSEELDHGVLVVGYGFEGADED-GKKYWIVKNSWSEKWGQNGYIYMAKDRKNHCGIASAASYP 336
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ENSAMXT00000047972.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000030.1:138766:150097:-1 gene:ENSAMXG00000038942.1 transcript:ENSAMXT00000047972.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 310.842 bits (795), Expect = 1.133e-103 Identity = 160/308 (51.95%), Postives = 201/308 (65.26%), Query Frame = 1
Query: 172 EYKTKFNKVYDEE-NEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEF---LDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL 1080
E+K KF K Y E E R+ IW NL+ + +HN+ + G + LG+N F D+ +QEF L + K F K +P++V+W +GYVT VK+Q CGSCWAFS+TG++EGQ FKKT LVS SEQQLVDCS+SYGN GCNGG M AF Y+M G++ E+ YPY D C++++ V C YT I GSEE+L E + TVGP+SV +DA SFQ Y GIYDE CSSTQL+HGVLAVGYG +G+ YWLVKNSW SWG GYI+MS++KNNQCGIAT A YP +
Sbjct: 26 EWKLKFGKSYSSEAEESQRKMIWMTNLKLVLEHNMLADQGLKSHRLGMNHFADMENQEFRKMLSRCLGSFDTTKIHNATKFTGKAGGAAVPDTVDWRTQGYVTEVKSQGLCGSCWAFSSTGALEGQMFKKTGSLVSLSEQQLVDCSESYGNNGCNGGLMSYAFNYVMNNGGLDTEASYPYEGQDSVCRFNQYSVGATCSGYTFISSGSEEELKEVVGTVGPVSVAVDA-EVSFQLYQSGIYDESDCSSTQLNHGVLAVGYG--SQNGKDYWLVKNSWSTSWGEAGYIRMSRNKNNQCGIATFALYPEV 330
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ctsl.1 (cathepsin L1-like [Source:NCBI gene;Acc:103023607]) HSP 1 Score: 309.686 bits (792), Expect = 4.502e-103 Identity = 156/305 (51.15%), Postives = 203/305 (66.56%), Query Frame = 1
Query: 175 YKTKFNKVYDE-ENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIY---MKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYI-MKFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
+K KF K+Y E E R+ W N + + HN+ + G Y LG+ F D+ ++E+ ++ + K+ +F ++ LP++V+W KGYVT +K+Q CGSCWAFS TGS+EGQ F+KT KLVS SEQQLVDCS YGN GC GG MDQAF+YI GI+ E YPY A+DG+C++ V C + DI G E+ L E +AT+GPISV IDA + SFQ Y GIY+E CSST+LDHGVLAVGYG D+G+ YWLVKNSWG WG GYI+MS++++NQCGIATM+SYP
Sbjct: 29 WKLKFGKIYHSVEEESQRKLTWLTNRKLVLVHNMLADQGIKSYRLGMTFFADMDNKEYRKLFASCLGSFNRTKAHSATTFLRQTLRDPLPDTVDWRPKGYVTDIKDQKDCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGDYGNFGCGGGLMDQAFEYIKANKGIDTEDSYPYEAVDGDCRFKPDSVGATCTGFVDITSGDEKALQEAVATIGPISVAIDAGHSSFQLYESGIYNEPDCSSTELDHGVLAVGYGT--DNGKDYWLVKNSWGLDWGNKGYIQMSRNEDNQCGIATMSSYP 331
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ENSAMXT00000042132.1 (cathepsin L1-like [Source:NCBI gene;Acc:103023924]) HSP 1 Score: 306.99 bits (785), Expect = 4.595e-102 Identity = 158/339 (46.61%), Postives = 205/339 (60.47%), Query Frame = 1
Query: 70 MMHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIY---MKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
M F+ + L+ A +I + F +K K KVY+ E R+ W N + + HN+ + G Y LG+ F D+ +QE+ + + K+ SF ++ LPN+V+W +GYVT VKNQ CGSCWAFS TG++EGQ F+K L+ SEQQLVDCS+ YGN GC+GG+M+QAFQY+ G++ E YPY AM+G C+Y V C Y DI G E+ L E +ATVGP+SV ID + SFQ Y G+YDE CS++ L H VLAVGYG D G+ YWLVKNSWG WG GYIKMS++KNNQCGIAT ASYP
Sbjct: 1 MRVFLAVATLVAVVGAASISMEDLEFHA-------WKLKLGKVYNPAEESQRKITWLANRKLVLVHNMLADQGLKTYRLGMTHFADMDNQEYRQMLQGCLGSFNETKAPGASSFLRQAGGATLPNTVDWRTQGYVTEVKNQEMCGSCWAFSATGALEGQMFRKLGYLLPLSEQQLVDCSREYGNMGCSGGWMNQAFQYVKDNGGLDTEDSYPYEAMEGYCRYYPDAVGATCSGYVDISIGDEQALQEAVATVGPVSVAIDVGHYSFQLYQSGVYDEPDCSTSALGHAVLAVGYG--SDYGQDYWLVKNSWGTYWGDQGYIKMSRNKNNQCGIATAASYP 330
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ENSAMXT00000048039.1 (cathepsin L1-like [Source:NCBI gene;Acc:103023924]) HSP 1 Score: 306.99 bits (785), Expect = 4.595e-102 Identity = 158/339 (46.61%), Postives = 205/339 (60.47%), Query Frame = 1
Query: 70 MMHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIY---MKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
M F+ + L+ A +I + F +K K KVY+ E R+ W N + + HN+ + G Y LG+ F D+ +QE+ + + K+ SF ++ LPN+V+W +GYVT VKNQ CGSCWAFS TG++EGQ F+K L+ SEQQLVDCS+ YGN GC+GG+M+QAFQY+ G++ E YPY AM+G C+Y V C Y DI G E+ L E +ATVGP+SV ID + SFQ Y G+YDE CS++ L H VLAVGYG D G+ YWLVKNSWG WG GYIKMS++KNNQCGIAT ASYP
Sbjct: 1 MRVFLAVATLVAVVGAASISMEDLEFHA-------WKLKLGKVYNPAEESQRKITWLANRKLVLVHNMLADQGLKTYRLGMTHFADMDNQEYRQMLQGCLGSFNETKAPGASSFLRQAGGATLPNTVDWRTQGYVTEVKNQEMCGSCWAFSATGALEGQMFRKLGYLLPLSEQQLVDCSREYGNMGCSGGWMNQAFQYVKDNGGLDTEDSYPYEAMEGYCRYYPDAVGATCSGYVDISIGDEQALQEAVATVGPVSVAIDVGHYSFQLYQSGVYDEPDCSTSALGHAVLAVGYG--SDYGQDYWLVKNSWGTYWGDQGYIKMSRNKNNQCGIATAASYP 330
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011285.1 (pep scaffold:Pmarinus_7.0:GL499136:454:1347:-1 gene:ENSPMAG00000010258.1 transcript:ENSPMAT00000011285.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 309.686 bits (792), Expect = 2.601e-104 Identity = 155/297 (52.19%), Postives = 200/297 (67.34%), Query Frame = 1
Query: 193 KVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPI--VKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMK-FGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
K YD+ E RR IWE+NL+ I HN+E+++G+H + +G+N+F D++ +EF + R R + K P SV+W K+GYVT VK+Q CGSCWAFSTTGS+EGQ+ +KT LVS SEQ LVDCS + GN GC GG MD AF YI K GI+ E+ YPYTA D NC+Y+ + + DI G+EE L +A+VGP+S+GIDAS SFQ Y+ GIY + CS+ LDHGVL VGYGVD+D K+W+VKNSWG WG +GYI M++DK+N CGIAT ASYP
Sbjct: 1 KTYDQNEEGWRRMIWEKNLKKIAVHNLEHSMGKHTWRMGMNRFGDMTKEEFQHTMLGLRGSNDTSKASRGATFMAPAFFKAPESVDWRKQGYVTDVKDQGDCGSCWAFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSAEGNNGCKGGLMDLAFTYIKKNGGIDSEASYPYTAKDENCKYNPKNKAAEDTGFVDIPSGNEEALKNAVASVGPVSIGIDASLESFQLYSSGIYSDSDCSN-NLDHGVLVVGYGVDDDE-RKFWIVKNSWGTKWGDHGYILMARDKDNLCGIATAASYP 295
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006499.1 (pep scaffold:Pmarinus_7.0:GL477089:42202:47941:1 gene:ENSPMAG00000005817.1 transcript:ENSPMAT00000006499.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 302.368 bits (773), Expect = 6.346e-101 Identity = 154/336 (45.83%), Postives = 215/336 (63.99%), Query Frame = 1
Query: 88 IILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEF---LDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGN-CQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
++ ++ A P I DE W +K K+Y+ + E RR IWE+NL I+ HN+E++LG+H + +G+N F D++++EF ++ Y +P V + S ++ + P +V+W KG VT VK+Q +CGSCWAFSTTG++EGQ+ +K +LVS SEQ LVDCS++ GN+GC GG MDQAFQY+ GI+ E+ YPYT DG+ C Y + + D+ G E+ L +A+VGP+SV IDAS+ SFQ Y G+Y E CSS LDHGVL VGYGV ++G+KYW+VKNSW WG GY+ M+++K N CGIAT ASYP
Sbjct: 7 LVPALLAVMASATP---IHDPMLDEEWGSWKGFHQKLYEPKQESWRRMIWEKNLNKIKIHNLEHSLGKHTWRMGMNHFGDMTNEEFRQKMNGYHGVQP--HKVSKGSTFLVPQNYEAPPTVDWRDKGLVTEVKDQGECGSCWAFSTTGALEGQHMRKVGQLVSLSEQNLVDCSRAEGNQGCGGGLMDQAFQYVKDNGGIDSEAAYPYTGTDGDKCHYDPKFNSANDTGFVDVTSGDEKALKIAVASVGPVSVAIDASHESFQFYQSGVYFEPDCSSQDLDHGVLVVGYGVKGTGENGKKYWIVKNSWSPKWGDEGYVLMARNKKNHCGIATAASYP 337
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010475.1 (pep scaffold:Pmarinus_7.0:GL482653:10321:33550:-1 gene:ENSPMAG00000009483.1 transcript:ENSPMAT00000010475.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 298.516 bits (763), Expect = 4.239e-100 Identity = 148/293 (50.51%), Postives = 194/293 (66.21%), Query Frame = 1
Query: 205 EENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPI--VKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMK-FGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
+E E RR IWE+NL+ I HN+E+++G+H + +G+NQF+D++ +EF + + +R R + + P SV+W K+GYVT +KNQ CGSCW+FSTTGS+EGQ+ +KT LVS SEQ LVDCS + GN GCNGG M AF YI K GI+ E YPY C+Y + Y +I +G EE L +A+VGP+SV IDAS SFQSY GIY + CS +DH VL VGYGVDE G+K+WLVKNSWG +WG GY++M++D NN CGIATM+SYP
Sbjct: 1 QEEEGWRRIIWEKNLKRISVHNLEHSMGKHTWRMGMNQFSDMTGEEFQQVMLGFRGWNGTSKAPRGATFMAPAFFEAPESVDWRKQGYVTDIKNQGDCGSCWSFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSTEGNHGCNGGLMINAFNYIKKNGGIDSEESYPYKGQVETCKYDPKNKAAEVTGYVEIPEGDEEALMNAVASVGPVSVAIDASLASFQSYGSGIYKDAMCSH-HIDHAVLVVGYGVDE-MGQKFWLVKNSWGVTWGEQGYVRMARDDNNLCGIATMSSYP 291
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003800.1 (pep scaffold:Pmarinus_7.0:GL485125:12828:20107:1 gene:ENSPMAG00000003453.1 transcript:ENSPMAT00000003800.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 277.715 bits (709), Expect = 7.313e-92 Identity = 142/288 (49.31%), Postives = 187/288 (64.93%), Query Frame = 1
Query: 223 RRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPI--VKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMK-FGIEKESVYPYTAMD-GNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
RR IWE+NL+ I HN+E+++G+H + +G+N+F D++ +EF + + +R R + + P SV+W K+GYVT VKNQ CGSCW+FSTTGS+EGQ+ +KT LVS SEQ LVDCS + GN GCNGG M AF YI K GI+ E YPY C+Y+ + Y +I +G EE L +A+VGP+SV IDAS SF Y GIY ++ CS ++H VL VGYGVDE G+K+WLVKNSWG WG GY++M++D NN CGIA ASYP
Sbjct: 8 RRMIWEQNLKKIAVHNLEHSMGKHTWRMGMNRFGDMTGEEFQQVMLGFRGWNGTSKAPRGATFMAPAFFEAPESVDWRKQGYVTDVKNQGDCGSCWSFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSTEGNYGCNGGLMINAFNYIKKNGGIDSEESYPYKGQGVETCKYNPKNKAAEVTGYVEIPEGDEEALKNAVASVGPVSVAIDASLNSFLYYISGIYKDKLCSHI-INHAVLVVGYGVDE-KGDKFWLVKNSWGVQWGEKGYVRMARDDNNLCGIAVTASYP 293
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008535.1 (pep scaffold:Pmarinus_7.0:GL478103:36116:54424:1 gene:ENSPMAG00000007699.1 transcript:ENSPMAT00000008535.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 277.715 bits (709), Expect = 3.812e-91 Identity = 140/310 (45.16%), Postives = 197/310 (63.55%), Query Frame = 1
Query: 151 GFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSL-----KLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMD-GNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD--EDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGI 1053
D W + F K Y + + RR IWEEN++F+ +HN+E++LG H YTLG+N DL+ EF YR S ER L ++P S++W +G VTP+KNQ QCGSCWAFS+TG++EGQ+ +++ +LV SEQ L+DCS+ G EGC GG+MD AFQY++ + GI+ ES YPYTA D +C Y +++ R + DI +GSE+DL +A+VGP+SV IDA + SFQ Y GIY E C+ T+LDH VL VG+GV ++G+K+W+VKN G G Y++++ DK CG+
Sbjct: 31 ALDGHWEAWTVYFKKAYTQTDGIKRRLIWEENMRFVDRHNLEHSLGLHSYTLGMNHLADLTVDEFRKTMNGYRR--GSRERHEGHHTSTFLAPENYEVPQSMDWRDQGLVTPIKNQGQCGSCWAFSSTGALEGQWKRRSGELVPLSEQNLLDCSRPEGTEGCGGGWMDDAFQYVLDQGGIDSESDYPYTATDVDSCHYDPSRMVARISGFVDIHKGSEKDLITAVASVGPVSVAIDAGHQSFQLYESGIYYEPECNCTELDHAVLVVGFGVKGRGENGKKFWIVKNRRGLQCGGEIYLEVAVDKRCFCGL 338
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO46465 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RPY5]) HSP 1 Score: 347.436 bits (890), Expect = 1.878e-118 Identity = 176/332 (53.01%), Postives = 216/332 (65.06%), Query Frame = 1
Query: 82 IRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKF-GIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
+ + +LI CF+E D W +K K Y E E +RR IW +NL+ ++KHN E H Y L +N F DL+ EF +M YR S +F +++LP V+W KG+VT VKNQ QCGSCWAFS+TGS+EGQ+F+KT KLVS SEQ LVDCS+ YGN GC GG MD AF+YI GI+ E YPYTA DG C + V YTD+ +GSE DL +ATVGPISV IDA + SFQ Y G+Y E CSSTQLDHGVLAVGYG ++ G+ YWLVKNSWG+ WG+NGYIKMS++K+NQCGIAT ASYP
Sbjct: 8 LLVAVLIAQCFSELSQ---------DRQWHAWKDFHGKTYTGEEEDLRRAIWNDNLEIVKKHNAE----NHSYKLDMNHFADLTVTEFKQRFMGYRAASNSTGGSTF-LPLSNVQLPAEVDWRDKGFVTAVKNQGQCGSCWAFSSTGSLEGQHFRKTGKLVSLSEQNLVDCSKKYGNNGCEGGLMDYAFKYIKNNDGIDTEQSYPYTARDGQCHFKPGSVGATVTGYTDVQRGSEGDLQSAVATVGPISVAIDAGHSSFQLYKTGVYSEPDCSSTQLDHGVLAVGYGAED--GKDYWLVKNSWGEGWGMNGYIKMSRNKDNQCGIATQASYP 323
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO45953 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRH6]) HSP 1 Score: 321.242 bits (822), Expect = 2.849e-108 Identity = 169/334 (50.60%), Postives = 216/334 (64.67%), Query Frame = 1
Query: 82 IRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVY-DEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERK-SFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYI-MKFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
+++ L++ A + WS F Q D W +K+ K Y D E R IW++NL+ I++HN E H Y + +N DL+ EF Y+ R S +R + ++K+P+SV+W +KGYVT VKNQ QCGSCWAFSTTGS+EGQ+F+KT LVS SEQ L+DCS SYGN GC GG MD AF+YI GI+ ES YPY G+C +S V R Y DI QGSE+ L +ATVGP+SV +DAS +Q Y+ G+YD CSSTQLDHGVL +GYG +G+ YWLVKNSWG SWG+ GYI MS++KNNQCGIA+ ASYP
Sbjct: 1 MKVFLVLCVLVASSRGWSVRFGQ--DSEWVAWKSYHGKSYSDVHEERTRMAIWQQNLEKIKRHNAE----DHSYKMAMNHLGDLTEDEFRYFYLGVRAHHNSTKRGWATYMPPSNVKIPSSVDWSQKGYVTGVKNQGQCGSCWAFSTTGSVEGQHFRKTGSLVSLSEQNLIDCSGSYGNNGCQGGLMDNAFRYIESNGGIDTESSYPYLGQQGSCHFSSSHVGARVTGYQDIPQGSEQALQSAVATVGPVSVAVDASQ--WQFYSSGVYDNPYCSSTQLDHGVLVIGYG--NYNGQDYWLVKNSWGYSWGVEGYIMMSRNKNNQCGIASSASYP 324
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO36727 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SHX1]) HSP 1 Score: 311.227 bits (796), Expect = 3.120e-104 Identity = 168/334 (50.30%), Postives = 207/334 (61.98%), Query Frame = 1
Query: 94 LLIVPCFAETIPWSGIFFQGFDE---LWSEYKTKFNKVYDE-ENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERK--SFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMK-FGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
LL+ C + SG F FDE W +K K Y E R+ IW +NL+ IQKHN E H +TL +N DL+ EF Y R + +K S +++P++V+W K+GYVTPVKNQ QCGSCWAFSTTGS+EGQ FKKT KLVS SEQ LVDCS +YGN GC GG MD AF+YI + GI+ E YPY A + C++ K + + D+ G EE L TVGPISV IDA + SFQ Y+ G+Y+ CSST LDHGVL VGYG + G YWLVKNSWG+ WG+ GYI MS++KNNQCG+AT ASYP
Sbjct: 3 LLVAACLLFAVA-SG-FVVKFDEDEQQWQAWKLFHTKKYTTVTEEGARKAIWRDNLKKIQKHNAE----GHSFTLAMNHLGDLTQDEFRYFYTGMRSHYSNYTKKQGSAFLAPSHVQVPDTVDWRKEGYVTPVKNQGQCGSCWAFSTTGSLEGQNFKKTGKLVSLSEQNLVDCSTAYGNNGCQGGLMDYAFKYIKENGGIDTEESYPYEARNDRCRFQKSNIGAVDTGFVDVTHGDEEALKTAAGTVGPISVAIDAGHMSFQFYHSGVYNNAGCSSTSLDHGVLVVGYGTYQ--GSDYWLVKNSWGERWGMEGYIMMSRNKNNQCGVATQASYP 328
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO45852 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRL9]) HSP 1 Score: 301.597 bits (771), Expect = 1.726e-100 Identity = 153/310 (49.35%), Postives = 204/310 (65.81%), Query Frame = 1
Query: 157 DELWSEYKTKFNKVYDEENEFVRRQ-IWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLD--IYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMK-FGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
D W +K+ K Y +NE R IW+ NL+ I HN G+H + L +N D++ E + +K + +S + + ++K+ +S++W KGYVTPVKNQ QCGSCWAFSTTG++EGQ+F+KT KLVS SEQ LVDCS YGN GC GG MD AFQYI + GI+ E YPY A DG C Y+K + + + DI G E L + LA+VGPIS+ IDAS +F Y+ G+YD+ CSST+LDHGVLAVGYG D+ G+ YWLVKNSWG SWG GYIK++++ +++CG+A+ ASYP
Sbjct: 26 DPNWKAWKSFHGKEYPNKNEETMRNFIWQNNLKKIVTHN----EGKHSFKLAMNHLGDMTSLEISQTLLGLKLKKHAESQPKGATFLPPANVKVVDSIDWRSKGYVTPVKNQGQCGSCWAFSTTGALEGQHFRKTGKLVSLSEQNLVDCSGKYGNNGCEGGLMDNAFQYIKENGGIDTEKSYPYLAKDGVCHYNKSAIGAKDTGFVDIPTGDENALQQALASVGPISIAIDASQSTFHFYHQGVYDDPDCSSTRLDHGVLAVGYGTDD--GKDYWLVKNSWGPSWGEEGYIKIARNDHDKCGVASKASYP 329
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO41322 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4P4]) HSP 1 Score: 213.001 bits (541), Expect = 1.236e-63 Identity = 125/321 (38.94%), Postives = 175/321 (54.52%), Query Frame = 1
Query: 160 ELWSEYKTKFNKVY-DEENEFVRRQIWEENLQFIQKHNIEYNLGRHK-YTLGVNQFTDLSHQEFLDIY-----------MKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKFG--IEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQ--LDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASY 1071
++ +Y K K Y D + RR+ ++ NL+FI N RH Y L +N D S +E + + Y+P + S+ +P+ +NWV +G VTPVK+Q CGSCW+F TTG++EG F KT+ L S+Q L+DCS GN C+GG +++QYIMK G +ES PY DG C ++ Y +I +G L +A GPISV IDAS+ S Y+ G+Y E C + LDH VLAVGYG + G+ YW++KNSW WG+NGY+ MS+ K+N CG+AT A+Y
Sbjct: 243 RVFDKYVKKHKKNYKDNKEHHTRREHFKHNLRFIHSKN-----RRHAGYYLAMNHLGDRSDKELRVLRGRRYTKGYNGGLPYKPDMASIN-----------DVPDEMNWVIRGAVTPVKDQAVCGSCWSFGTTGTIEGTLFLKTKYLTRLSQQNLMDCSWGEGNNACDGGEDFRSYQYIMKSGGIATEESYGPYLGADGYCHKKDAEIGATITGYVNITEGDLSALKTAIAQKGPISVSIDASHKSLSFYSYGVYYEPKCGNKNEDLDHSVLAVGYGTMD--GKPYWMIKNSWSTHWGMNGYVLMSQ-KDNNCGVATAATY 544
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsl (cathepsin L [Source:NCBI gene;Acc:100049246]) HSP 1 Score: 319.701 bits (818), Expect = 4.482e-107 Identity = 161/311 (51.77%), Postives = 210/311 (67.52%), Query Frame = 1
Query: 154 FDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGN-CQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVD-ED-SGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
D+ W +K +K Y E+ E RR +WE+NL+ I+ HN+E+++G+H Y LG+N F D++H+EF I Y+ + S + L+ P +V+W KGYVTPVK+Q QCGSCWAFSTTG++EGQ F+KT KLVS SEQ LVDCS+ GNEGCNGG MDQAFQY+ G++ E YPY D CQY+ + + DI G E L + +A+VGP+SV IDA + SFQ Y GIY E+ CSS +LDHGVL VGYG + ED G+KYW+VKNSW + WG G+I M+KD++N CGIAT ASYP
Sbjct: 24 LDQHWQLWKGWHSKNYHEKEEGWRRLVWEKNLRKIELHNLEHSMGKHSYRLGMNHFGDMTHEEFRQIMNGYKRREQRKYSGSLFMEPNFLEAPRAVDWRDKGYVTPVKDQGQCGSCWAFSTTGALEGQQFRKTGKLVSLSEQNLVDCSRPEGNEGCNGGLMDQAFQYVKDNQGLDSEDFYPYKGTDDQPCQYNAQYSAVNDTGFVDIPSGKERALMKAVASVGPVSVAIDAGHESFQFYQSGIYFEKECSSDELDHGVLVVGYGFEGEDVDGKKYWIVKNSWSEKWGDKGFIYMAKDRHNHCGIATAASYP 334
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsl.1 (cathepsin L1 [Source:NCBI gene;Acc:101171789]) HSP 1 Score: 314.694 bits (805), Expect = 4.584e-105 Identity = 162/306 (52.94%), Postives = 203/306 (66.34%), Query Frame = 1
Query: 175 YKTKFNKVYDEENEFV-RRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMK--YRPIVKSVERK--SFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKF-GIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
++ KF + Y E RRQ W N + + HNI + G Y LG+ F D+ ++E+ + + S+ R+ +F + ++ LP +V+W KGYVT VK+Q QCGSCWAFS TGS+EGQ F+KT KLVS SEQQLVDCS YGN GC GG MD AF+YI GI+ E YPY A DG C+Y V C Y D+ G E+ L E +AT+GPISVGIDAS+ SFQ Y G+YDE CSS++LDHGVLAVGYG ++G+ YWLVKNSWG +WG GYIKMSK+K+NQCGIAT ASYP
Sbjct: 34 WRLKFGRTYSSPTEEAQRRQTWLNNRKLVLVHNILADQGIKSYRLGMTYFADMENEEYKRLISQGCLGSFNASLPRRGSTFFRLPENKDLPAAVDWRDKGYVTDVKDQKQCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGDYGNMGCGGGLMDDAFRYIQATGGIDTEESYPYEAEDGECRYKPDAVGATCTGYVDVSSGDEDALQEAVATIGPISVGIDASHISFQLYESGLYDEPQCSSSELDHGVLAVGYG--SENGQDYWLVKNSWGLTWGDQGYIKMSKNKSNQCGIATAASYP 337
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctss2.1 (cathepsin S [Source:NCBI gene;Acc:101165175]) HSP 1 Score: 291.197 bits (744), Expect = 6.749e-96 Identity = 148/314 (47.13%), Postives = 191/314 (60.83%), Query Frame = 1
Query: 142 FFQGFDELWSEYKTKFNKVYDEENEFV-RRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVK-SVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIM-KFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
F D W +K +K Y E E V RR +WE NL I HN+EY++G H Y L +N DL+ +E L + RP E F S +P+ ++W +K VT VK Q CGSCWAFS G++EGQ +KT KLV S Q LVDCS YGN GCNGGFM QAFQY++ GI+ ++ YPY + NC YS C Y+ + +G E L E +AT+GPISV IDA+ P F Y G+YD+ SCS ++HGVLAVGYG +G+ YWLVKNSWG ++G GYI+M+++KN+QCGIA YP
Sbjct: 27 FDSRLDIHWELWKKTHSKHYPSEEEDVHRRDLWERNLMLITMHNLEYSMGLHTYDLSMNHMGDLTQEEILQQFASLRPPTNLKREPHLFVGASGSNNIPDEMDWRQKNCVTSVKMQGSCGSCWAFSAVGALEGQLCRKTGKLVDLSPQNLVDCSSKYGNHGCNGGFMHQAFQYVIDNQGIDSDAGYPYVGVTQNCHYSSEYRAANCSQYSFLPEGDEGALKEAIATIGPISVAIDATRPRFAFYRSGVYDDSSCSQN-VNHGVLAVGYGT--LNGQDYWLVKNSWGTTFGEQGYIRMARNKNDQCGIAMYGCYP 337
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctss (cathepsin S [Source:NCBI gene;Acc:100049247]) HSP 1 Score: 284.263 bits (726), Expect = 2.745e-93 Identity = 144/310 (46.45%), Postives = 192/310 (61.94%), Query Frame = 1
Query: 154 FDELWSEYKTKFNKVYDEE-NEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFL-DIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKF-GIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
D+ W+ +K ++K Y E EF RR+IWEENL+ I HN+E +LG H Y L +N DL+ +E + + P+ +ER +D + + +P SV+W + G VT VK Q +CGSCWAFS G++EGQ K T L S S Q LVDCS YGN GC GGFM AFQY++K GI ++ YPY C+Y + C Y + +G E L +AT+GPISV IDAS P F Y G+Y + SCS ++HGVL VGYG ++GE YWLVKNSWG+ +G GYIKM++++ NQCGIA A +P
Sbjct: 21 LDQHWNLWKKTYSKTYSHEIEEFGRRRIWEENLEMISVHNLEVSLGLHSYELAMNHLGDLTIEELIASLTGTVAPV--GLERIHYDLVKINTSVPESVDWREGGLVTSVKTQGRCGSCWAFSAVGALEGQLKKTTGILTSLSPQNLVDCSTKYGNYGCKGGFMSNAFQYVIKNQGISSDAAYPYIGKRDKCKYDSKHRAANCTGYNFLPKGDEFALKVGVATIGPISVAIDASRPKFLFYRHGVYKDHSCSH-NVNHGVLVVGYGT--ENGEDYWLVKNSWGERYGDGGYIKMARNRRNQCGIALYACFP 325
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsk (cathepsin K [Source:NCBI gene;Acc:101164922]) HSP 1 Score: 283.878 bits (725), Expect = 3.832e-93 Identity = 142/309 (45.95%), Postives = 194/309 (62.78%), Query Frame = 1
Query: 154 FDELWSEYKTKFNKVY-DEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMK-FGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
D W E+K K Y E E +RR IWE+NL+ I+ HN E LG H YTLG+NQF D++ +E ++ + + R + +KLP SV++ KKG VT VKNQ CGSCWAFS+ G++EGQ KKT LV S Q LVDC N+GC GG+M AF+Y+ + GI+ E+ YPY D C+Y+ + + K Y ++ +G E LA L GP+SVGIDAS SF Y GIY + +C+ ++H VLAVGYGV+ G+K+W+VKNSWG++WG GY+ M++++ N CGIA +ASYP
Sbjct: 24 LDAHWEEWKMTHTKEYITVEEEGIRRAIWEKNLRMIEAHNQEAALGMHTYTLGMNQFGDMTQEEVVERMTGLQMPLNPEPRVPMETDGSLIKLPKSVDYRKKGMVTSVKNQGSCGSCWAFSSVGALEGQLAKKTGNLVDLSPQNLVDCVTE--NDGCGGGYMTNAFKYVQENGGIDSEAAYPYMGEDQPCRYNVSGLAAQIKGYKEVPEGDEHALAVALFKAGPVSVGIDASQNSFLYYQKGIYFDRNCNKEDINHAVLAVGYGVNA-KGKKFWIVKNSWGETWGNKGYVLMARNRGNVCGIANLASYP 329
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049716.1 (SMESG000049716.1) HSP 1 Score: 704.131 bits (1816), Expect = 0.000e+0 Identity = 337/337 (100.00%), Postives = 337/337 (100.00%), Query Frame = 1
Query: 70 MMHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL 1080
MMHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL
Sbjct: 1 MMHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL 337
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049716.1 (SMESG000049716.1) HSP 1 Score: 702.205 bits (1811), Expect = 0.000e+0 Identity = 336/336 (100.00%), Postives = 336/336 (100.00%), Query Frame = 1
Query: 73 MHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL 1080
MHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL
Sbjct: 1 MHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYPNL 336
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049722.1 (SMESG000049722.1) HSP 1 Score: 402.905 bits (1034), Expect = 5.863e-140 Identity = 189/334 (56.59%), Postives = 249/334 (74.55%), Query Frame = 1
Query: 82 IRIILLIVPCFAETIPWSGIFFQ---GFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
++I+LL V C +I + F+ +E W+ YK +F + Y+ E RR IWEENL+ IQKHNIEY+LG+H Y LG+N+F D++++E+ + +PI K+ R F ++ LP SV+W KGYVTPVKNQ CGSCW+FSTTGS+EGQ+ +KT +L+S SEQQLVDCS+ +GN GCNGG MD AFQYI K+G+E E+ Y YTA +GNC+Y KV+ C + DI +G+E+DLA+ +ATVGPISV IDAS P+FQ Y GGIY+E+SCSS QLDHGVLAVGYG +++ + +W+VKNSWG WGL+GYIKM+KD++NQCGIATMASYP
Sbjct: 1 MKIVLLAVFCVV-SISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKYGLESEADYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYG--KENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYP 331
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049723.1 (SMESG000049723.1) HSP 1 Score: 396.356 bits (1017), Expect = 2.142e-137 Identity = 192/332 (57.83%), Postives = 242/332 (72.89%), Query Frame = 1
Query: 91 ILLIVPCFAETIPWSGIFFQGFDEL---WSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKS-FDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
I+++V F + + F EL W YKT+F K Y NE RR IWE+NL++IQ+HN+E++LG+H YTLG+N F D++++EF Y+ P K + S F LP+SV+W KG+VTPVKNQ QCGSCW+FSTTGS+EGQ+++KT+ L+SFSEQQLVDCS S+GN GC+GG MD AFQYI ++GIE ES YPYTA DGNC Y K KV+ C ++DI G+E+ LA +ATVGPISV IDASN SFQ Y GIY+E CSS+QLDHGVLA+GYG ++G+ +WLVKNSWG WG+ GYIKMSKD+ NQCGIATMASYP
Sbjct: 3 IIILVSLFLAAVSAAPQQFTINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSP--KRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGT--ENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGIATMASYP 330
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000014167.1 (SMESG000014167.1) HSP 1 Score: 390.963 bits (1003), Expect = 3.315e-135 Identity = 189/335 (56.42%), Postives = 238/335 (71.04%), Query Frame = 1
Query: 70 MMHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFVRRQIWEENLQFIQKHNIEYNLGRHKYTLGVNQFTDLSHQEFLDIYMKYRPIVKSVERKSFDKKRKSLKLPNSVNWVKKGYVTPVKNQLQCGSCWAFSTTGSMEGQYFKKTRKLVSFSEQQLVDCSQSYGNEGCNGGFMDQAFQYIMKFGIEKESVYPYTAMDGNCQYSKRKVITRCKNYTDIDQGSEEDLAEKLATVGPISVGIDASNPSFQSYNGGIYDEESCSSTQLDHGVLAVGYGVDEDSGEKYWLVKNSWGDSWGLNGYIKMSKDKNNQCGIATMASYP 1074
M F+ I + +V A +S ++ W YKT+F + Y+ E RR IWE+NL++I++HN+EY+LG+H Y LG+N++ DL+++EF ++ S + F LP +V+W KGYVTPVKNQ QCGSCWAFSTTGS+EGQ+F+KT LVSFSEQQLVDCS +YGNEGC GG MD AF YIMK+G+E E YPYTA DG C+Y + KV+ C +TDI G+E DLA +ATVGP+SV IDAS+ SFQ Y GGIY+E CS QLDHGVLAVGYG ++G YWLVKNSWG SWGL+GYIKMSKD+NNQCGI+T AS+P
Sbjct: 1 MKAFVLISVFLVAIQARRPTFS--LNSELNKDWELYKTQFKRQYEPLTEITRRIIWEQNLEYIRQHNLEYDLGKHTYYLGLNEYADLTNEEFKAKFLGKILTRSSRKGSQFMAPENMGALPTTVDWRTKGYVTPVKNQQQCGSCWAFSTTGSLEGQHFRKTGSLVSFSEQQLVDCSGAYGNEGCGGGLMDNAFNYIMKYGLESERDYPYTATDGKCKYDRSKVVGTCSGFTDIKHGNESDLAVAVATVGPVSVAIDASHYSFQLYKGGIYNEPQCSPDQLDHGVLAVGYG--SENGGNYWLVKNSWGISWGLSGYIKMSKDRNNQCGISTSASFP 331 The following BLAST results are available for this feature:
BLAST of Cathepsin L2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Cathepsin L2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30023605 ID=SMED30023605|Name=Cathepsin L2|organism=Schmidtea mediterranea sexual|type=transcript|length=1230bpback to top protein sequence of SMED30023605-orf-1 >SMED30023605-orf-1 ID=SMED30023605-orf-1|Name=SMED30023605-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=338bp MMHFIRIILLIVPCFAETIPWSGIFFQGFDELWSEYKTKFNKVYDEENEFback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|
