p2X purinoceptor 4

Overview
Namep2X purinoceptor 4
Smed IDSMED30023527
Length (bp)1657
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of p2X purinoceptor 4 (SMED30023527) t-SNE clustered cells

Violin plots show distribution of expression levels for p2X purinoceptor 4 (SMED30023527) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of p2X purinoceptor 4 (SMED30023527) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for p2X purinoceptor 4 (SMED30023527) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30023527

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 10

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parapharyngeal regionSMED30023527h1SMcG0003707 SmedASXL_005765SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
nervous systemSMED30023527h1SMcG0003707 dd_Smed_v4_10968_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30023527h1SMcG0003707 dd_Smed_v4_10968_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30023527h1SMcG0003707 dd_Smed_v4_10968_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30023527h1SMcG0003707 dd_Smed_v4_10968_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
anterior sideSMED30023527h1SMcG0003707 dd_Smed_v4_10968_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
pharynxSMED30023527h1SMcG0003707 Contig54325uc_Smed_v2PMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
pharynxSMED30023527h1SMcG0003707 Contig54325newmark_estsPMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
secretory cellSMED30023527h1SMcG0003707 Contig54325uc_Smed_v2PMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
secretory cellSMED30023527h1SMcG0003707 Contig54325newmark_estsPMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Human
Match: P2RX4 (purinergic receptor P2X 4 [Source:HGNC Symbol;Acc:HGNC:8535])

HSP 1 Score: 293.508 bits (750), Expect = 7.075e-94
Identity = 165/370 (44.59%), Postives = 235/370 (63.51%), Query Frame = 3 
Query:   99 IPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLD--DFDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRAR 1199
            + A +FEY+T ++V IRS KVG++ R  QL I+ YV  WV   EKGYQ  D  V+ VT K+KG+A  N SK G  +WDVAD+V+P Q+ ++ FV TN+++T NQT G CPE  D   V CKSD+ C         +GV TGRCV        K CE+  WCP E+D   +P    L +A NFT+L+KN+I +PKF   +RNIL  +   +L SC YD K   + FCPIF+L  ++  +    +++   G ++ I + W+CNLD     C+P Y+FRRLD  D + +V  G+NFR++++Y +  G E+RTLIK YGI+  I V G+ GKF+     +N+GSGLALLG+A+VLCD++VL  ++KR +Y+  +
Sbjct:    8 LAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTV-CKSDASCTAGSAGTHSNGVSTGRCVA--FNGSVKTCEVAAWCPVEDDTH-VPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAK--TDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYREKK 371
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Human
Match: P2RX4 (purinergic receptor P2X 4 [Source:HGNC Symbol;Acc:HGNC:8535])

HSP 1 Score: 283.878 bits (725), Expect = 6.676e-90
Identity = 165/386 (42.75%), Postives = 235/386 (60.88%), Query Frame = 3 
Query:   99 IPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVA----------------LWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLD--DFDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRAR 1199
            + A +FEY+T ++V IRS KVG++ R  QL I+ YV                  WV   EKGYQ  D  V+ VT K+KG+A  N SK G  +WDVAD+V+P Q+ ++ FV TN+++T NQT G CPE  D   V CKSD+ C         +GV TGRCV        K CE+  WCP E+D   +P    L +A NFT+L+KN+I +PKF   +RNIL  +   +L SC YD K   + FCPIF+L  ++  +    +++   G ++ I + W+CNLD     C+P Y+FRRLD  D + +V  G+NFR++++Y +  G E+RTLIK YGI+  I V G+ GKF+     +N+GSGLALLG+A+VLCD++VL  ++KR +Y+  +
Sbjct:    8 LAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGCYHPHLAEVEMESPRRWVFVWEKGYQETDSVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTV-CKSDASCTAGSAGTHSNGVSTGRCVA--FNGSVKTCEVAAWCPVEDDTH-VPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAK--TDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYREKK 387
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Human
Match: P2RX4 (purinergic receptor P2X 4 [Source:HGNC Symbol;Acc:HGNC:8535])

HSP 1 Score: 279.641 bits (714), Expect = 3.149e-89
Identity = 146/330 (44.24%), Postives = 205/330 (62.12%), Query Frame = 3 
Query:   99 IPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLD--DFDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFN 1079
            + A +FEY+T ++V IRS KVG++ R  QL I+ YV  WV   EKGYQ  D  V+ VT K+KG+A  N SK G  +WDVAD+V+P Q+ ++ FV TN+++T NQT G CPE  D   V CKSD+ C         +GV TGRCV        K CE+  WCP E+D   +P    L +A NFT+L+KN+I +PKF   +RNIL  +   +L SC YD K   + FCPIF+L  ++  +    +++   G ++ I + W+CNLD     C+P Y+FRRLD  D + +V  G+NFR++++Y +  G E+RTLIK YGI+  I V G+ GKF+
Sbjct:    8 LAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTV-CKSDASCTAGSAGTHSNGVSTGRCVA--FNGSVKTCEVAAWCPVEDDTH-VPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAK--TDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFD 331
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Human
Match: P2RX5 (purinergic receptor P2X 5 [Source:HGNC Symbol;Acc:HGNC:8536])

HSP 1 Score: 276.944 bits (707), Expect = 4.273e-87
Identity = 141/372 (37.90%), Postives = 216/372 (58.06%), Query Frame = 3 
Query:  108 TIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPV-AGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDD-FDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQFQ 1214
            ++F+Y+T K V  ++ KVG++YRL Q  I+ Y+ +WV  ++KGYQ  D  + + V  K+KG+AF N S  G  +WDVAD+V+P Q  + FFV TN+++T NQ    C E+  +    C  DSDC     +  G+GV TGRC+  +       CEI+ WCP E      P +P L  A +FT+ +KN I FPKF   + N++   D+ FL SC + PK   N +CPIF+L  +I ++ +  ++I   G +I I+IEWNC+LD    +C P Y+F RLD+     V  G+NFR++ +Y +  GVE RTL+K YGI+  + V+G+G  F                      CDLV++ +++KR+FY+  + ++ +
Sbjct:   12 SLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAENEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRE-NLARGTCEIFAWCPLETSSR--PEEPFLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPK---NHYCPIFRLGSVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGKGAFF----------------------CDLVLIYLIKKREFYRDKKYEEVR 355
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Human
Match: P2RX5-TAX1BP3 (P2RX5-TAX1BP3 readthrough (NMD candidate) [Source:HGNC Symbol;Acc:HGNC:49191])

HSP 1 Score: 276.559 bits (706), Expect = 9.058e-87
Identity = 141/372 (37.90%), Postives = 216/372 (58.06%), Query Frame = 3 
Query:  108 TIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPV-AGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDD-FDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQFQ 1214
            ++F+Y+T K V  ++ KVG++YRL Q  I+ Y+ +WV  ++KGYQ  D  + + V  K+KG+AF N S  G  +WDVAD+V+P Q  + FFV TN+++T NQ    C E+  +    C  DSDC     +  G+GV TGRC+  +       CEI+ WCP E      P +P L  A +FT+ +KN I FPKF   + N++   D+ FL SC + PK   N +CPIF+L  +I ++ +  ++I   G +I I+IEWNC+LD    +C P Y+F RLD+     V  G+NFR++ +Y +  GVE RTL+K YGI+  + V+G+G  F                      CDLV++ +++KR+FY+  + ++ +
Sbjct:   12 SLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAENEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRE-NLARGTCEIFAWCPLETSSR--PEEPFLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPK---NHYCPIFRLGSVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGKGAFF----------------------CDLVLIYLIKKREFYRDKKYEEVR 355
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Zebrafish
Match: p2rx4a (purinergic receptor P2X, ligand-gated ion channel, 4a [Source:ZFIN;Acc:ZDB-GENE-020806-2])

HSP 1 Score: 284.648 bits (727), Expect = 1.049e-90
Identity = 166/387 (42.89%), Postives = 236/387 (60.98%), Query Frame = 3 
Query:   78 LSELLEC---IPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLD--DFDFDVGKGWNFRYSEHYY-ENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRAR---IDQF 1211
            +SE + C   +    F+Y TSK++ IRS KVG + R TQ  +I YV  +V    KGYQ  D  ++ VT K+KGIA  N S+ G  +WDVAD+++PPQ++ +FFV TNM+IT NQT  +C E+      TC S  DC +      G GV TGRCV        K CE+  WCP E  V P P  PLL+ A NFTVL+KN+I +PKF   +RNIL  ++  +L  C +  K   +  CPIF+L D++  +    + +  HG ++ + I W+C+LD+    CVP YTFRRLD  D D +V  G+NFR++++Y   +G E RTLIK YGI+  + V G+ GKFN     +N+G+GLALLG+ +V+CD +VL  ++++  YK  +   +D F
Sbjct:    1 MSESVGCCDSVSQCFFDYYTSKILIIRSKKVGTLNRFTQALVIAYVIGYVCVYNKGYQDTDTVLSSVTTKVKGIALTNTSELGERIWDVADYIIPPQEDGSFFVLTNMIITTNQTQSKCAENP-TPASTCTSHRDCKRGFNDARGDGVRTGRCV--SYSASVKTCEVLSWCPLEKIVDP-PNPPLLADAENFTVLIKNNIRYPKFNFNKRNILPNINSSYLTHCVFSRK--TDPDCPIFRLGDIVGEAEEDFQIMAVHGGVMGVQIRWDCDLDMPQSWCVPRYTFRRLDNKDPDNNVAPGYNFRFAKYYKNSDGTETRTLIKGYGIRFDVMVFGQAGKFNIIPTLLNMGAGLALLGLVNVICDWIVLTFMKRKQHYKEQKYTYVDDF 381
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Zebrafish
Match: p2rx4a (purinergic receptor P2X, ligand-gated ion channel, 4a [Source:ZFIN;Acc:ZDB-GENE-020806-2])

HSP 1 Score: 277.33 bits (708), Expect = 9.886e-88
Identity = 166/396 (41.92%), Postives = 236/396 (59.60%), Query Frame = 3 
Query:   78 LSELLEC---IPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQ---------QNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLD--DFDFDVGKGWNFRYSEHYY-ENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRAR---IDQF 1211
            +SE + C   +    F+Y TSK++ IRS KVG + R TQ  +I YV  +V    KGYQ  D  ++ VT K+KGIA  N S+ G  +WDVAD+++PPQ         ++ +FFV TNM+IT NQT  +C E+      TC S  DC +      G GV TGRCV        K CE+  WCP E  V P P  PLL+ A NFTVL+KN+I +PKF   +RNIL  ++  +L  C +  K   +  CPIF+L D++  +    + +  HG ++ + I W+C+LD+    CVP YTFRRLD  D D +V  G+NFR++++Y   +G E RTLIK YGI+  + V G+ GKFN     +N+G+GLALLG+ +V+CD +VL  ++++  YK  +   +D F
Sbjct:    1 MSESVGCCDSVSQCFFDYYTSKILIIRSKKVGTLNRFTQALVIAYVIGYVCVYNKGYQDTDTVLSSVTTKVKGIALTNTSELGERIWDVADYIIPPQVVRRLDEEEEDGSFFVLTNMIITTNQTQSKCAENP-TPASTCTSHRDCKRGFNDARGDGVRTGRCV--SYSASVKTCEVLSWCPLEKIVDP-PNPPLLADAENFTVLIKNNIRYPKFNFNKRNILPNINSSYLTHCVFSRK--TDPDCPIFRLGDIVGEAEEDFQIMAVHGGVMGVQIRWDCDLDMPQSWCVPRYTFRRLDNKDPDNNVAPGYNFRFAKYYKNSDGTETRTLIKGYGIRFDVMVFGQAGKFNIIPTLLNMGAGLALLGLVNVICDWIVLTFMKRKQHYKEQKYTYVDDF 390
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Zebrafish
Match: p2rx4a (purinergic receptor P2X, ligand-gated ion channel, 4a [Source:ZFIN;Acc:ZDB-GENE-020806-2])

HSP 1 Score: 276.944 bits (707), Expect = 1.278e-87
Identity = 166/396 (41.92%), Postives = 236/396 (59.60%), Query Frame = 3 
Query:   78 LSELLEC---IPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQ---------QNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLD--DFDFDVGKGWNFRYSEHYY-ENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRAR---IDQF 1211
            +SE + C   +    F+Y TSK++ IRS KVG + R TQ  +I YV  +V    KGYQ  D  ++ VT K+KGIA  N S+ G  +WDVAD+++PPQ         ++ +FFV TNM+IT NQT  +C E+      TC S  DC +      G GV TGRCV        K CE+  WCP E  V P P  PLL+ A NFTVL+KN+I +PKF   +RNIL  ++  +L  C +  K   +  CPIF+L D++  +    + +  HG ++ + I W+C+LD+    CVP YTFRRLD  D D +V  G+NFR++++Y   +G E RTLIK YGI+  + V G+ GKFN     +N+G+GLALLG+ +V+CD +VL  ++++  YK  +   +D F
Sbjct:    1 MSESVGCCDSVSQCFFDYYTSKILIIRSKKVGTLNRFTQALVIAYVIGYVCVYNKGYQDTDTVLSSVTTKVKGIALTNTSELGERIWDVADYIIPPQVVRRLDEEEEDGSFFVLTNMIITTNQTQSKCAENP-TPASTCTSHRDCKRGFNDARGDGVRTGRCV--SYSASVKTCEVLSWCPLEKIVDP-PNPPLLADAENFTVLIKNNIRYPKFNFNKRNILPNINSSYLTHCVFSRK--TDPDCPIFRLGDIVGEAEEDFQIMAVHGGVMGVQIRWDCDLDMPQSWCVPRYTFRRLDNKDPDNNVAPGYNFRFAKYYKNSDGTETRTLIKGYGIRFDVMVFGQAGKFNIIPTLLNIGAGLALLGLVNVICDWIVLTFMKRKQHYKEQKYTYVDDF 390
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Zebrafish
Match: p2rx1 (purinergic receptor P2X, ligand-gated ion channel, 1 [Source:ZFIN;Acc:ZDB-GENE-030319-1])

HSP 1 Score: 276.174 bits (705), Expect = 3.099e-87
Identity = 153/368 (41.58%), Postives = 226/368 (61.41%), Query Frame = 3 
Query:  114 FEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRL------DDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRAR 1199
            FEYET + V +++ +V I+ R+ QLG++ Y+  WV   EKGYQ  D  +  V  K+KG++F N+S    I WDVAD+V P Q +S+F V TN + T  Q  G+CPE  D     C +DSDC  ++   TG+G +TGRC+     N T+ CEIY WCP E+D   IP  P+L +A N+T+ +KNSI FP+F V R N++  +D+ ++N+C Y PK      CPIF+L D++  S      I   G  I + I+W+CNLD++   C P+Y F  L      D  D     G+NFR++++Y EN V+KRTL+K +G++  I V G  GKF+       +GSG+ + G+A+V+CDL++L I+ K++FYK  +
Sbjct:   17 FEYETPREVLVKNRRVAIVCRIIQLGVLAYIIGWVFMYEKGYQTVDNAIGSVFTKMKGVSFTNISGQERI-WDVADYVFPEQGDSSFVVMTNFIPTIGQVQGKCPELPDGKN-KCTNDSDCDDSKYKRTGNGHMTGRCM-----NKTQTCEIYSWCPVEDD-RKIPDPPILLTAENYTLFIKNSITFPQFDVVRSNLVEGIDQNYINNCVYHPK--TAPLCPIFRLGDIVERSGFSFSEIARVGGAIGVLIDWDCNLDLSIRFCKPKYEFYGLYGTGKNDQVD-KASLGYNFRFAKYYVENSVQKRTLMKVFGVRIDIIVHGLAGKFDIIPTLTAIGSGVGIFGVATVVCDLLLLYILPKKNFYKTMK 373
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Zebrafish
Match: p2rx1 (purinergic receptor P2X, ligand-gated ion channel, 1 [Source:ZFIN;Acc:ZDB-GENE-030319-1])

HSP 1 Score: 276.174 bits (705), Expect = 3.099e-87
Identity = 153/368 (41.58%), Postives = 226/368 (61.41%), Query Frame = 3 
Query:  114 FEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRL------DDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRAR 1199
            FEYET + V +++ +V I+ R+ QLG++ Y+  WV   EKGYQ  D  +  V  K+KG++F N+S    I WDVAD+V P Q +S+F V TN + T  Q  G+CPE  D     C +DSDC  ++   TG+G +TGRC+     N T+ CEIY WCP E+D   IP  P+L +A N+T+ +KNSI FP+F V R N++  +D+ ++N+C Y PK      CPIF+L D++  S      I   G  I + I+W+CNLD++   C P+Y F  L      D  D     G+NFR++++Y EN V+KRTL+K +G++  I V G  GKF+       +GSG+ + G+A+V+CDL++L I+ K++FYK  +
Sbjct:   17 FEYETPREVLVKNRRVAIVCRIIQLGVLAYIIGWVFMYEKGYQTVDNAIGSVFTKMKGVSFTNISGQERI-WDVADYVFPEQGDSSFVVMTNFIPTIGQVQGKCPELPDGKN-KCTNDSDCDDSKYKRTGNGHMTGRCM-----NKTQTCEIYSWCPVEDD-RKIPDPPILLTAENYTLFIKNSITFPQFDVVRSNLVEGIDQNYINNCVYHPK--TAPLCPIFRLGDIVERSGFSFSEIARVGGAIGVLIDWDCNLDLSIRFCKPKYEFYGLYGTGKNDQVD-KASLGYNFRFAKYYVENSVQKRTLMKVFGVRIDIIVHGLAGKFDIIPTLTAIGSGVGIFGVATVVCDLLLLYILPKKNFYKTMK 373
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Xenopus
Match: p2rx5 (purinergic receptor P2X, ligand gated ion channel, 5 [Source:NCBI gene;Acc:100485445])

HSP 1 Score: 291.582 bits (745), Expect = 3.640e-93
Identity = 158/376 (42.02%), Postives = 236/376 (62.77%), Query Frame = 3 
Query:  108 TIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPV-AGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDD--FDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQFQKEL 1223
            + F+Y+T K V  ++ KVGI++R+ QL I+ Y+  WV  ++KGYQ  D  + + +  KLKG+AF N S+ G  +WDV D+V+PPQ  + FFV TN+++T NQ    CPES  +    C  +SDC +   +  G+GV TGRC+ +   N T  CEI+ WCP E    P    PLL  A NFTV +KNSI FPKF   + NIL   +  +L +CRY      + +CPIF L  +++++ ++ +++   G +I I IEWNCNLD    +C P Y+F RLD+   +  V  G+NFR++++Y + NG + RTLIK YGI+  I V+G+ GKFN     +N+GSGLALLG  +  CDLV+L +++K +FY+  + ++ ++ L
Sbjct:   12 SFFDYKTEKYVIAKNKKVGILFRVVQLSILAYLVGWVFVVKKGYQETDTSIQSSIITKLKGVAFTNTSELGERLWDVVDYVIPPQGENVFFVVTNLIVTPNQRQSTCPESFGIPDAECSKNSDCPEGEPVVAGNGVKTGRCLKTGAVNATGTCEIFAWCPIEKKKKPK--TPLLGKAENFTVYIKNSIRFPKFDFSKTNILETDNGSYLKTCRYSKD---DHYCPIFHLGKIVSWAGSEFQSMAIEGGVIGIQIEWNCNLDKLASECHPHYSFTRLDNKFTEKSVSSGYNFRFAKYYRDANGNDYRTLIKAYGIRFDIMVNGKAGKFNIIPTIINIGSGLALLGAGAFFCDLVLLYLIKKSNFYRDKKFEEVKRCL 382
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Xenopus
Match: p2rx5 (purinergic receptor P2X, ligand gated ion channel, 5 [Source:NCBI gene;Acc:100485445])

HSP 1 Score: 291.582 bits (745), Expect = 6.825e-93
Identity = 157/373 (42.09%), Postives = 234/373 (62.73%), Query Frame = 3 
Query:  108 TIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPV-AGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDD--FDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQFQ 1214
            + F+Y+T K V  ++ KVGI++R+ QL I+ Y+  WV  ++KGYQ  D  + + +  KLKG+AF N S+ G  +WDV D+V+PPQ  + FFV TN+++T NQ    CPES  +    C  +SDC +   +  G+GV TGRC+ +   N T  CEI+ WCP E    P    PLL  A NFTV +KNSI FPKF   + NIL   +  +L +CRY      + +CPIF L  +++++ ++ +++   G +I I IEWNCNLD    +C P Y+F RLD+   +  V  G+NFR++++Y + NG + RTLIK YGI+  I V+G+ GKFN     +N+GSGLALLG  +  CDLV+L +++K +FY+  + ++ +
Sbjct:   12 SFFDYKTEKYVIAKNKKVGILFRVVQLSILAYLVGWVFVVKKGYQETDTSIQSSIITKLKGVAFTNTSELGERLWDVVDYVIPPQGENVFFVVTNLIVTPNQRQSTCPESFGIPDAECSKNSDCPEGEPVVAGNGVKTGRCLKTGAVNATGTCEIFAWCPIEKKKKPK--TPLLGKAENFTVYIKNSIRFPKFDFSKTNILETDNGSYLKTCRYSKD---DHYCPIFHLGKIVSWAGSEFQSMAIEGGVIGIQIEWNCNLDKLASECHPHYSFTRLDNKFTEKSVSSGYNFRFAKYYRDANGNDYRTLIKAYGIRFDIMVNGKAGKFNIIPTIINIGSGLALLGAGAFFCDLVLLYLIKKSNFYRDKKFEEVK 379
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Xenopus
Match: p2rx5 (purinergic receptor P2X, ligand gated ion channel, 5 [Source:NCBI gene;Acc:100485445])

HSP 1 Score: 290.812 bits (743), Expect = 7.191e-93
Identity = 157/375 (41.87%), Postives = 235/375 (62.67%), Query Frame = 3 
Query:  108 TIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPV-AGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDD--FDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQFQKE 1220
            + F+Y+T K V  ++ KVGI++R+ QL I+ Y+  WV  ++KGYQ  D  + + +  KLKG+AF N S+ G  +WDV D+V+PPQ  + FFV TN+++T NQ    CPES  +    C  +SDC +   +  G+GV TGRC+ +   N T  CEI+ WCP E    P    PLL  A NFTV +KNSI FPKF   + NIL   +  +L +CRY      + +CPIF L  +++++ ++ +++   G +I I IEWNCNLD    +C P Y+F RLD+   +  V  G+NFR++++Y + NG + RTLIK YGI+  I V+G+ GKFN     +N+GSGLALLG  +  CDLV+L +++K +FY+  + ++  ++
Sbjct:   12 SFFDYKTEKYVIAKNKKVGILFRVVQLSILAYLVGWVFVVKKGYQETDTSIQSSIITKLKGVAFTNTSELGERLWDVVDYVIPPQGENVFFVVTNLIVTPNQRQSTCPESFGIPDAECSKNSDCPEGEPVVAGNGVKTGRCLKTGAVNATGTCEIFAWCPIEKKKKPK--TPLLGKAENFTVYIKNSIRFPKFDFSKTNILETDNGSYLKTCRYSKD---DHYCPIFHLGKIVSWAGSEFQSMAIEGGVIGIQIEWNCNLDKLASECHPHYSFTRLDNKFTEKSVSSGYNFRFAKYYRDANGNDYRTLIKAYGIRFDIMVNGKAGKFNIIPTIINIGSGLALLGAGAFFCDLVLLYLIKKSNFYRDKKFEEVGRQ 381
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Xenopus
Match: p2rx5 (purinergic receptor P2X, ligand gated ion channel, 5 [Source:NCBI gene;Acc:100485445])

HSP 1 Score: 291.197 bits (744), Expect = 1.193e-92
Identity = 158/374 (42.25%), Postives = 234/374 (62.57%), Query Frame = 3 
Query:  108 TIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPV-AGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDD--FDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQFQK 1217
            + F+Y+T K V  ++ KVGI++R+ QL I+ Y+  WV  ++KGYQ  D  + + +  KLKG+AF N S+ G  +WDV D+V+PPQ  + FFV TN+++T NQ    CPES  +    C  +SDC +   +  G+GV TGRC+ +   N T  CEI+ WCP E    P    PLL  A NFTV +KNSI FPKF   + NIL   +  +L +CRY      + +CPIF L  +++++ ++ +++   G +I I IEWNCNLD    +C P Y+F RLD+   +  V  G+NFR++++Y + NG + RTLIK YGI+  I V+G+ GKFN     +N+GSGLALLG  +  CDLV+L +++K +FY+  + ++  K
Sbjct:   12 SFFDYKTEKYVIAKNKKVGILFRVVQLSILAYLVGWVFVVKKGYQETDTSIQSSIITKLKGVAFTNTSELGERLWDVVDYVIPPQGENVFFVVTNLIVTPNQRQSTCPESFGIPDAECSKNSDCPEGEPVVAGNGVKTGRCLKTGAVNATGTCEIFAWCPIEKKKKPK--TPLLGKAENFTVYIKNSIRFPKFDFSKTNILETDNGSYLKTCRYSKD---DHYCPIFHLGKIVSWAGSEFQSMAIEGGVIGIQIEWNCNLDKLASECHPHYSFTRLDNKFTEKSVSSGYNFRFAKYYRDANGNDYRTLIKAYGIRFDIMVNGKAGKFNIIPTIINIGSGLALLGAGAFFCDLVLLYLIKKSNFYRDKKFEEVNK 380
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Xenopus
Match: ENSXETT00000000163.1 (purinergic receptor P2X, ligand gated ion channel, 4 [Source:NCBI gene;Acc:100489363])

HSP 1 Score: 290.426 bits (742), Expect = 1.639e-92
Identity = 156/368 (42.39%), Postives = 236/368 (64.13%), Query Frame = 3 
Query:  105 ATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLD--DFDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRAR 1199
            + IF+Y+T ++  I+S K+G + R  QLGI+ YV  WV   EKGYQ FD  V+ VT+K+KG+A  N S+ G  +WDVAD+++P Q+ +AFFV TN+++T NQT G CPE  +     C     C    +    +GV TG+CV  +   +T  CEI+ WCP END   +P    L+ A NFTVL+KN+I +PKF+  +RNIL+ +   +L SC+YD  +  + FCPIF+L  ++  +    +++   G ++ I I W+C+LD     CVP+Y+FRRLD  + D +V  G+NFR+++++ + NGVE R+L+K YGI+  I V G  GKF+     +N+GSG AL G+A+VLCD++V +  +KR +Y+  +
Sbjct:   23 SCIFDYDTPRIALIKSRKIGFLNRFIQLGILAYVIGWVFIWEKGYQEFDTVVSSVTSKVKGVAVTNTSELGVKIWDVADYIIPAQEENAFFVMTNLILTQNQTQGYCPELPE--NSVCSEKQPCTPGYVGKQSNGVQTGKCVPYNSTVNT--CEIFAWCPVENDTH-VPDPAFLNGAENFTVLIKNNIWYPKFQAFKRNILSNISSSYLKSCQYDKVN--HPFCPIFRLGSIVKEAGETFRDMAVQGGVMGIQINWDCDLDWKLTYCVPKYSFRRLDNREIDHNVSPGYNFRFAKYFKDSNGVESRSLMKVYGIRFDILVFGTAGKFDIIPTMINIGSGAALFGVATVLCDMIVFHFFKKRHYYREKK 383
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Mouse
Match: P2rx4 (purinergic receptor P2X, ligand-gated ion channel 4 [Source:MGI Symbol;Acc:MGI:1338859])

HSP 1 Score: 281.182 bits (718), Expect = 2.980e-89
Identity = 159/355 (44.79%), Postives = 225/355 (63.38%), Query Frame = 3 
Query:  105 ATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLD--DFDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVL 1160
            A +FEY+T ++V IRS KVG++ R+ QL I+ YV  WV   EKGYQ  D  V+ VT K KG+A  N S+ G  +WDVAD+VVP Q+ ++ F+ TNM++T NQT G CPE  D   + C SD++C         SG+ TGRCV        K CE+  WCP END   +P    L +A NFT+L+KN+I +PKF   +RNIL  +   +L SC Y+ +   + FCPIF+L  ++  +    + +   G ++ I I+W+CNLD     C+P Y+FRRLD  D + +V  G+NFR++++Y +  G E+RTL K YGI+  I V G+ GKF+     +N+GSGLALLG+A+VLCD++VL
Sbjct:   10 AFLFEYDTPRIVLIRSRKVGLMNRVVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKAKGVAVTNTSQLGFRIWDVADYVVPAQEENSLFIMTNMIVTVNQTQGTCPEIPDKTSI-CDSDANCTLGSSDTHSSGIGTGRCV--PFNASVKTCEVAAWCPVENDA-GVPTPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTSYLKSCIYNAR--TDPFCPIFRLGQIVADAGHSFQEMAVEGGIMGIQIKWDCNLDRAASHCLPRYSFRRLDTRDLEHNVSPGYNFRFAKYYRDLAGNEQRTLTKAYGIRFDIIVFGKAGKFDIIPTMINVGSGLALLGVATVLCDVIVL 358
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Mouse
Match: P2rx4 (purinergic receptor P2X, ligand-gated ion channel 4 [Source:MGI Symbol;Acc:MGI:1338859])

HSP 1 Score: 268.855 bits (686), Expect = 9.170e-85
Identity = 140/324 (43.21%), Postives = 199/324 (61.42%), Query Frame = 3 
Query:  105 ATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLD--DFDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRG 1067
            A +FEY+T ++V IRS KVG++ R+ QL I+ YV  WV   EKGYQ  D  V+ VT K KG+A  N S+ G  +WDVAD+VVP Q+ ++ F+ TNM++T NQT G CPE  D   + C SD++C         SG+ TGRCV        K CE+  WCP END   +P    L +A NFT+L+KN+I +PKF   +RNIL  +   +L SC Y+ +   + FCPIF+L  ++  +    + +   G ++ I I+W+CNLD     C+P Y+FRRLD  D + +V  G+NFR++++Y +  G E+RTL K YGI+  I V G+ 
Sbjct:   10 AFLFEYDTPRIVLIRSRKVGLMNRVVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKAKGVAVTNTSQLGFRIWDVADYVVPAQEENSLFIMTNMIVTVNQTQGTCPEIPDKTSI-CDSDANCTLGSSDTHSSGIGTGRCV--PFNASVKTCEVAAWCPVENDA-GVPTPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTSYLKSCIYNAR--TDPFCPIFRLGQIVADAGHSFQEMAVEGGIMGIQIKWDCNLDRAASHCLPRYSFRRLDTRDLEHNVSPGYNFRFAKYYRDLAGNEQRTLTKAYGIRFDIIVFGKA 327
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Mouse
Match: P2rx5 (purinergic receptor P2X, ligand-gated ion channel, 5 [Source:MGI Symbol;Acc:MGI:2137026])

HSP 1 Score: 268.47 bits (685), Expect = 1.669e-83
Identity = 152/377 (40.32%), Postives = 231/377 (61.27%), Query Frame = 3 
Query:  108 TIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPV-AGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTK-VCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDD-FDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQF--QKE 1220
            ++F+Y+T+K V  +S KVG++YR+ QL I+LY+ +WV  ++K YQ  D  + + V  K+KG+A+ N +  G  +WDVADFV+P Q  + FFV TN+++T NQ  G C E   +    C  D+DC     +  G G+ TGRC+   + N T+  CEI+ WCP E   MP    PLL  A  FT+ +KN I FPKF   + N+L   +K FL +C +      N +CPIF+L  ++ ++ A  ++I   G +I IHIEW+C+LD     C P Y F RLD+     +  G+NFR++ +Y + +GVE R L+K YGI+  + V+G+ GKF+     +N+GSGLAL+G  +  CDLV++ ++RK +FY+  + ++   QKE
Sbjct:   12 SLFDYKTAKFVVAKSKKVGLLYRVLQLTILLYLLIWVFLIKKSYQDIDTSLQSAVVTKVKGVAYTNTTMLGERLWDVADFVIPSQGENVFFVVTNLIVTPNQRQGICAEREGIPDGECSEDTDCHAGESVVAGHGLKTGRCL--RVGNSTRGTCEIFAWCPVETKSMPT--DPLLKDAEGFTIFIKNFIRFPKFNFSKANVLETGNKHFLKTCHFSST---NLYCPIFRLGSIVRWAGADFQDIALKGGVIGIHIEWDCDLDKAASHCNPHYYFNRLDNKHTQSISSGYNFRFARYYRDPHGVEFRDLMKAYGIRFDVIVNGKAGKFSIIPTVINIGSGLALMGAGAFFCDLVLIYLIRKSEFYRDKKFEKVRGQKE 381
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Mouse
Match: P2rx5 (purinergic receptor P2X, ligand-gated ion channel, 5 [Source:MGI Symbol;Acc:MGI:2137026])

HSP 1 Score: 255.758 bits (652), Expect = 6.011e-80
Identity = 140/371 (37.74%), Postives = 214/371 (57.68%), Query Frame = 3 
Query:  108 TIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPV-AGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTK-VCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDD-FDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQ 1208
            ++F+Y+T+K V  +S KVG++YR+ QL I+LY+ +WV  ++K YQ  D  + + V  K+KG+A+ N +  G  +WDVADFV+P Q  + FFV TN+++T NQ  G C E   +    C  D+DC     +  G G+ TGRC+   + N T+  CEI+ WCP E   MP    PLL  A  FT+ +KN I FPKF   + N+L   +K FL +C +      N +CPIF+L  ++ ++ A  ++I   G +I IHIEW+C+LD     C P Y F RLD+     +  G+NFR++ +Y + +GVE R L+K YGI+  + V+G+G  F                      CDLV++ ++RK +FY+  + ++
Sbjct:   12 SLFDYKTAKFVVAKSKKVGLLYRVLQLTILLYLLIWVFLIKKSYQDIDTSLQSAVVTKVKGVAYTNTTMLGERLWDVADFVIPSQGENVFFVVTNLIVTPNQRQGICAEREGIPDGECSEDTDCHAGESVVAGHGLKTGRCL--RVGNSTRGTCEIFAWCPVETKSMPT--DPLLKDAEGFTIFIKNFIRFPKFNFSKANVLETGNKHFLKTCHFSST---NLYCPIFRLGSIVRWAGADFQDIALKGGVIGIHIEWDCDLDKAASHCNPHYYFNRLDNKHTQSISSGYNFRFARYYRDPHGVEFRDLMKAYGIRFDVIVNGKGAFF----------------------CDLVLIYLIRKSEFYRDKKFEK 353
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Mouse
Match: P2rx3 (purinergic receptor P2X, ligand-gated ion channel, 3 [Source:MGI Symbol;Acc:MGI:1097160])

HSP 1 Score: 254.603 bits (649), Expect = 5.484e-79
Identity = 145/378 (38.36%), Postives = 220/378 (58.20%), Query Frame = 3 
Query:   90 LECIPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPV-AGVTAKLKGIA-FANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFD--FDVGKGWNFRYSEHY-YENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQ 1208
            + CI +  F YET+K V ++SW +GII R  QL II Y   WV   EK YQV D  + + V  K+KG   +AN       V DV+D+V PPQ  S F + T M++T NQ  G CPE+ + +   C SDS C   R    G G++TGRCV  +  +  + CEI GWCPTE D + +P   ++  A NFT+ +KNSI FP F  ++ N+L  +  K +  CR+ P+  +  FCPI ++ D++ F+      +   G ++ I I W C+LD  +++C+P+Y+F RLD       V  G+NFR++++Y  ENG E RTL+K +GI+  + V G  GKFN     ++  +    +G+ +VLCD+++LN ++  D YK  + ++
Sbjct:    1 MNCI-SDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGFGRYANR------VMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPENEEKY--RCVSDSQCGPERF--PGGGILTGRCV--NYSSVRRTCEIQGWCPTEVDTVEMP---IMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTDKDIKKCRFHPE--KAPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDGVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADHYKARKFEE 360
[Close]
BLAST of p2X purinoceptor 4 vs. UniProt/SwissProt
Match: sp|Q99571|P2RX4_HUMAN (P2X purinoceptor 4 OS=Homo sapiens OX=9606 GN=P2RX4 PE=1 SV=2)

HSP 1 Score: 293.508 bits (750), Expect = 3.398e-93
Identity = 165/370 (44.59%), Postives = 235/370 (63.51%), Query Frame = 3 
Query:   99 IPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLD--DFDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRAR 1199
            + A +FEY+T ++V IRS KVG++ R  QL I+ YV  WV   EKGYQ  D  V+ VT K+KG+A  N SK G  +WDVAD+V+P Q+ ++ FV TN+++T NQT G CPE  D   V CKSD+ C         +GV TGRCV        K CE+  WCP E+D   +P    L +A NFT+L+KN+I +PKF   +RNIL  +   +L SC YD K   + FCPIF+L  ++  +    +++   G ++ I + W+CNLD     C+P Y+FRRLD  D + +V  G+NFR++++Y +  G E+RTLIK YGI+  I V G+ GKF+     +N+GSGLALLG+A+VLCD++VL  ++KR +Y+  +
Sbjct:    8 LAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTV-CKSDASCTAGSAGTHSNGVSTGRCVA--FNGSVKTCEVAAWCPVEDDTH-VPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAK--TDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYREKK 371
[Close]
BLAST of p2X purinoceptor 4 vs. UniProt/SwissProt
Match: sp|P51577|P2RX4_RAT (P2X purinoceptor 4 OS=Rattus norvegicus OX=10116 GN=P2rx4 PE=1 SV=1)

HSP 1 Score: 284.263 bits (726), Expect = 1.385e-89
Identity = 159/353 (45.04%), Postives = 224/353 (63.46%), Query Frame = 3 
Query:  111 IFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLD--DFDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVL 1160
            +FEY+T ++V IRS KVG++ R  QL I+ YV  WV   EKGYQ  D  V+ VT K KG+A  N S+ G  +WDVAD+V+P Q+ ++ F+ TNM++T NQT   CPE  D   + C SD+DC    +    SGV TGRCV        K CE+  WCP ENDV  +P    L +A NFT+L+KN+I +PKF   +RNIL  +   +L SC Y+ +   + FCPIF+L  ++  +    + +   G ++ I I+W+CNLD     C+P Y+FRRLD  D + +V  G+NFR++++Y +  G E+RTL K YGI+  I V G+ GKF+     +N+GSGLALLG+A+VLCD++VL
Sbjct:   12 LFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKAKGVAVTNTSQLGFRIWDVADYVIPAQEENSLFIMTNMIVTVNQTQSTCPEIPDKTSI-CNSDADCTPGSVDTHSSGVATGRCV--PFNESVKTCEVAAWCPVENDV-GVPTPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTSYLKSCIYNAQ--TDPFCPIFRLGTIVEDAGHSFQEMAVEGGIMGIQIKWDCNLDRAASLCLPRYSFRRLDTRDLEHNVSPGYNFRFAKYYRDLAGKEQRTLTKAYGIRFDIIVFGKAGKFDIIPTMINVGSGLALLGVATVLCDVIVL 358
[Close]
BLAST of p2X purinoceptor 4 vs. UniProt/SwissProt
Match: sp|Q5E9U1|P2RX4_BOVIN (P2X purinoceptor 4 OS=Bos taurus OX=9913 GN=P2RX4 PE=2 SV=1)

HSP 1 Score: 283.878 bits (725), Expect = 1.576e-89
Identity = 163/357 (45.66%), Postives = 224/357 (62.75%), Query Frame = 3 
Query:   99 IPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLD--DFDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVL 1160
            + A +FEY+T ++V IRS KVG++ R  QL I+ YV  WV   EKGYQ  D  V+ VT K KG+   N SK G  +WDVAD+V+P Q+ ++ F+ TNMVIT NQT G CPE      V C++D++C         SGV TGRCV        K CE+  WCP E+D   +P    L +A NFT+L+KN+I +PKF   +RNIL  +   +L +C YD K   + FCPIF+L  ++  +    ++I   G ++ I I+WNCNLD     C+P Y+FRRLD  D   +V  G+NFR++++Y +  G E RTLIK YGI+  I V G+ GKF+     +N+GSGLALLG+A+VLCD++VL
Sbjct:    8 LGAFLFEYDTPRIVLIRSRKVGLMNRTVQLLILAYVIGWVFVWEKGYQETDSVVSSVTVKAKGVTMTNTSKLGFRIWDVADYVIPAQEENSVFIMTNMVITMNQTQGLCPEIPGKTTV-CETDANCTAGSAGTHSSGVATGRCV--SFNGTLKTCEVAAWCPVEDDT-EVPKPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTAYLKTCIYDAK--TDPFCPIFRLGKIVESAGHSFQDIAIEGGIMGIQIKWNCNLDRAASFCLPRYSFRRLDTRDLAHNVSPGYNFRFAKYYSDLKGAEHRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGVATVLCDVIVL 358
[Close]
BLAST of p2X purinoceptor 4 vs. UniProt/SwissProt
Match: sp|Q9JJX6|P2RX4_MOUSE (P2X purinoceptor 4 OS=Mus musculus OX=10090 GN=P2rx4 PE=1 SV=1)

HSP 1 Score: 280.411 bits (716), Expect = 4.137e-88
Identity = 158/353 (44.76%), Postives = 224/353 (63.46%), Query Frame = 3 
Query:  111 IFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLD--DFDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVL 1160
            +FEY+T ++V IRS KVG++ R+ QL I+ YV  WV   EKGYQ  D  V+ VT K KG+A  N S+ G  +WDVAD+VVP Q+ ++ F+ TNM++T NQT G CPE  D   + C SD++C         SG+ TGRCV        K CE+  WCP END   +P    L +A NFT+L+KN+I +PKF   +RNIL  +   +L SC Y+ +   + FCPIF+L  ++  +    + +   G ++ I I+W+CNLD     C+P Y+FRRLD  D + +V  G+NFR++++Y +  G E+RTL K YGI+  I V G+ GKF+     +N+GSGLALLG+A+VLCD++VL
Sbjct:   12 LFEYDTPRIVLIRSRKVGLMNRVVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKAKGVAVTNTSQLGFRIWDVADYVVPAQEENSLFIMTNMIVTVNQTQGTCPEIPDKTSI-CDSDANCTLGSSDTHSSGIGTGRCV--PFNASVKTCEVAAWCPVENDA-GVPTPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTSYLKSCIYNAR--TDPFCPIFRLGQIVADAGHSFQEMAVEGGIMGIQIKWDCNLDRAASHCLPRYSFRRLDTRDLEHNVSPGYNFRFAKYYRDLAGNEQRTLTKAYGIRFDIIVFGKAGKFDIIPTMINVGSGLALLGVATVLCDVIVL 358
[Close]
BLAST of p2X purinoceptor 4 vs. UniProt/SwissProt
Match: sp|Q93086|P2RX5_HUMAN (P2X purinoceptor 5 OS=Homo sapiens OX=9606 GN=P2RX5 PE=2 SV=4)

HSP 1 Score: 276.944 bits (707), Expect = 2.052e-86
Identity = 141/372 (37.90%), Postives = 216/372 (58.06%), Query Frame = 3 
Query:  108 TIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPV-AGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDD-FDFDVGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQFQ 1214
            ++F+Y+T K V  ++ KVG++YRL Q  I+ Y+ +WV  ++KGYQ  D  + + V  K+KG+AF N S  G  +WDVAD+V+P Q  + FFV TN+++T NQ    C E+  +    C  DSDC     +  G+GV TGRC+  +       CEI+ WCP E      P +P L  A +FT+ +KN I FPKF   + N++   D+ FL SC + PK   N +CPIF+L  +I ++ +  ++I   G +I I+IEWNC+LD    +C P Y+F RLD+     V  G+NFR++ +Y +  GVE RTL+K YGI+  + V+G+G  F                      CDLV++ +++KR+FY+  + ++ +
Sbjct:   12 SLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAENEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRE-NLARGTCEIFAWCPLETSSR--PEEPFLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPK---NHYCPIFRLGSVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGKGAFF----------------------CDLVLIYLIKKREFYRDKKYEEVR 355
[Close]
BLAST of p2X purinoceptor 4 vs. TrEMBL
Match: A0A0R3T876 (Uncharacterized protein OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS3263 PE=4 SV=1)

HSP 1 Score: 487.263 bits (1253), Expect = 1.061e-165
Identity = 242/378 (64.02%), Postives = 292/378 (77.25%), Query Frame = 3 
Query:   78 LSELLECIPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLS--KTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARID 1205
            L          +F+YET KVVQI S+K+G  YRL QLGI+LYVALWVMY EKGYQ FD   +GVTAKLKGIAF+N S    GA+VWD AD+VVPPQQ SAFFV TN++ T  QTL  C ES DV    C +++DCI  RII +GSGV TGRC+ S  K    VCEIYGWCPTENDV+P   + +L +APNFTVLLKNSIEFP+++VKRRNIL+WMDK+FL++CRY+P   R K+CPIF+L D++ ++ A+NKNIW  G ++SIHIEWNCNLD +  +C+P+Y FRRLDDF+  VGKGWNFR+S HY ENG+ KR LIK YGIQ FITV G+GGKF+   FSMNLGSGLALLGIA+VLCD +VLNI RKRD Y+ AR+D
Sbjct:    5 LQAFWRACSTNLFDYETQKVVQINSFKIGCTYRLIQLGIVLYVALWVMYYEKGYQAFDEATSGVTAKLKGIAFSNFSGQNIGAVVWDAADYVVPPQQRSAFFVMTNLISTPGQTLSTCDESPDVFESICTTNNDCISGRIIMSGSGVQTGRCIASKRKPHQNVCEIYGWCPTENDVLP--DKFILQNAPNFTVLLKNSIEFPRYRVKRRNILSWMDKRFLSTCRYNPHDERMKYCPIFRLGDIMEYTGAENKNIWYKGGMVSIHIEWNCNLDYDENQCLPKYIFRRLDDFESAVGKGWNFRFSHHYLENGIRKRNLIKAYGIQFFITVYGKGGKFHLLTFSMNLGSGLALLGIATVLCDTIVLNITRKRDLYRNARVD 380
[Close]
BLAST of p2X purinoceptor 4 vs. TrEMBL
Match: A0A183AE62 (Uncharacterized protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS5247 PE=4 SV=1)

HSP 1 Score: 489.96 bits (1260), Expect = 4.745e-165
Identity = 244/382 (63.87%), Postives = 297/382 (77.75%), Query Frame = 3 
Query:   69 MKILSELLECIPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKT---GAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARID 1205
            M   +     + +++ EYET KVVQI S KVGI++RL QLGI LYV LWVM  EKGYQ FD  V+GVTAKLKGIAFAN+S     GA VWD AD+V+PPQQNSAFFV TN+V T  QTL  C E+ DV+G +CK+D+DC   R++ TGSG+ TGRCV S  + + +VCEIYGWCPTE D+ P P   LLSSA NFTV+LKNSIEFP+++VKRRNIL WMDK +L +CRY+P   R KFCPIF+L D++ +S+A NK+IW +G ++SIHIEWNCNLD + EKCVP+Y FRRLDDF+  V +GWNFR+S+HY ENG+ KR LIK YGIQ FITV G GGKFN   FSMNLGSGLALLGIA+VLCD++VLNI RKR  Y+RA++D
Sbjct:    1 MGRYTSFFGSLASSLLEYETQKVVQIHSKKVGILFRLIQLGIFLYVVLWVMVYEKGYQSFDQAVSGVTAKLKGIAFANVSDNPSIGASVWDAADYVIPPQQNSAFFVMTNLVSTPGQTLTTCEEAHDVYGNSCKNDTDCQPGRLVMTGSGIQTGRCVPSTRQKNLQVCEIYGWCPTEYDITPKPH--LLSSAENFTVILKNSIEFPRYRVKRRNILPWMDKLYLKTCRYNPYDERMKFCPIFRLGDILKYSDATNKDIWQNGGMVSIHIEWNCNLDFDVEKCVPKYVFRRLDDFESPVAQGWNFRFSQHYMENGIRKRNLIKAYGIQFFITVYGTGGKFNVLTFSMNLGSGLALLGIATVLCDMIVLNITRKRGLYRRAKVD 380
[Close]
BLAST of p2X purinoceptor 4 vs. TrEMBL
Match: H2KQ33 (p2X purinoceptor 4 OS=Clonorchis sinensis OX=79923 GN=CLF_103111 PE=4 SV=1)

HSP 1 Score: 488.419 bits (1256), Expect = 1.811e-164
Identity = 240/370 (64.86%), Postives = 292/370 (78.92%), Query Frame = 3 
Query:  105 ATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKT---GAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARID 1205
            + + EYET KVVQI S KVGI +RL QLGIILYV +WVM  EKGYQ FD+ V+GVTAKLKGIAFAN++     GA VWD AD+V+PPQQNSAFFV TN+V T  Q+LGRC ES DV+G  C +D+ C    ++ TGSGV TGRCV S  +   KVCEIYGWCPTE+D+ P P   LL+SA NFTV+LKNSIEFP+++VKRRNIL WMDK FL +CRY+P   R KFCPIF+L D++ +S+A+NKN+W +G ++SIHIEW CNLD + EKCVP+Y FRRLDDF+  V KGWNFR+S+HY ENG  KR LIK +GIQ FITV G+GGKFN   FSMNLGSGLALLGIA+VLCD++VLN  RKR+ Y++A++D
Sbjct:   13 SGLLEYETQKVVQIHSLKVGITFRLIQLGIILYVVVWVMIFEKGYQQFDHAVSGVTAKLKGIAFANVTDNPAIGASVWDAADYVIPPQQNSAFFVMTNLVSTPGQSLGRCEESHDVYGNNCSNDTQCTAGHLVMTGSGVQTGRCVPSTRQKGLKVCEIYGWCPTEHDITPKPH--LLASAENFTVMLKNSIEFPRYRVKRRNILKWMDKLFLKTCRYNPHDERLKFCPIFRLGDILKYSDAQNKNLWQNGGMVSIHIEWTCNLDFDVEKCVPKYVFRRLDDFESPVAKGWNFRFSQHYMENGTHKRNLIKAHGIQFFITVYGKGGKFNIIQFSMNLGSGLALLGIATVLCDMIVLNTTRKRELYRKAKVD 380
[Close]
BLAST of p2X purinoceptor 4 vs. TrEMBL
Match: A0A3R7FR79 (P2X purinoceptor 4 OS=Clonorchis sinensis OX=79923 GN=P2RX4 PE=4 SV=1)

HSP 1 Score: 488.034 bits (1255), Expect = 3.291e-164
Identity = 240/370 (64.86%), Postives = 292/370 (78.92%), Query Frame = 3 
Query:  105 ATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKT---GAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARID 1205
            + + EYET KVVQI S KVGI +RL QLGIILYV +WVM  EKGYQ FD+ V+GVTAKLKGIAFAN++     GA VWD AD+V+PPQQNSAFFV TN+V T  Q+LGRC ES DV+G  C +D+ C    ++ TGSGV TGRCV S  +   KVCEIYGWCPTE+D+ P P   LL+SA NFTV+LKNSIEFP+++VKRRNIL WMDK FL +CRY+P   R KFCPIF+L D++ +S+A+NKN+W +G ++SIHIEW CNLD + EKCVP+Y FRRLDDF+  V KGWNFR+S+HY ENG  KR LIK +GIQ FITV G+GGKFN   FSMNLGSGLALLGIA+VLCD++VLN  RKR+ Y++A++D
Sbjct:   13 SGLLEYETQKVVQIHSLKVGITFRLIQLGIILYVVVWVMIFEKGYQQFDHAVSGVTAKLKGIAFANVTDNPAIGASVWDAADYVIPPQQNSAFFVMTNLVSTPGQSLGRCEESHDVYGNNCSNDTQCTAGHLVMTGSGVQTGRCVPSTRQKGLKVCEIYGWCPTEHDITPKPH--LLASAENFTVMLKNSIEFPRYRVKRRNILKWMDKLFLKTCRYNPHDERLKFCPIFRLGDILKYSDAQNKNLWQNGGMVSIHIEWTCNLDFDVEKCVPKYVFRRLDDFESPVAKGWNFRFSQHYMENGTHKRNLIKAHGIQFFITVYGKGGKFNIIQFSMNLGSGLALLGIATVLCDMIVLNTTRKRELYRKAKVD 380
[Close]
BLAST of p2X purinoceptor 4 vs. TrEMBL
Match: A0A075AJT7 (Uncharacterized protein OS=Opisthorchis viverrini OX=6198 GN=T265_00386 PE=4 SV=1)

HSP 1 Score: 487.649 bits (1254), Expect = 3.669e-164
Identity = 240/370 (64.86%), Postives = 292/370 (78.92%), Query Frame = 3 
Query:  105 ATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKT---GAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARID 1205
            + + EYET KVVQI S KVGI +RL QLGIILYV +WVM  EKGYQ FD+ V+GVTAKLKGIAFAN++     GA VWD AD+V+PPQQNSAFFV TN+V T  Q+LGRC ES DV+G  C +D+ C    ++ TGSGV TGRCV S  +   KVCEIYGWCPTE+D+ P P   LL+SA NFTV+LKNSIEFP+++VKRRNIL WMDK FL +CRY+P   R KFCPIF+L D++ +S+A+NKN+W +G ++SIHIEW CNLD + EKCVP+Y FRRLDDF+  V KGWNFR+S+HY ENG  KR LIK +GIQ FITV G+GGKFN   FSMNLGSGLALLGIA+VLCD++VLN  RKR+ Y++A++D
Sbjct:   13 SGLLEYETQKVVQIHSLKVGITFRLIQLGIILYVVVWVMIFEKGYQQFDHAVSGVTAKLKGIAFANVTDNPAIGASVWDAADYVIPPQQNSAFFVMTNLVSTPGQSLGRCEESHDVYGNNCSNDTQCTAGHLVMTGSGVQTGRCVPSTRQKGLKVCEIYGWCPTEHDITPKPH--LLASAENFTVMLKNSIEFPRYRVKRRNILKWMDKLFLKTCRYNPNDERLKFCPIFRLGDILKYSDAQNKNLWQNGGMVSIHIEWTCNLDFDVEKCVPKYVFRRLDDFESPVAKGWNFRFSQHYMENGTHKRNLIKAHGIQFFITVYGKGGKFNIIQFSMNLGSGLALLGIATVLCDMIVLNTTRKRELYRKAKVD 380
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Cavefish
Match: p2rx1 (purinergic receptor P2X 1 [Source:NCBI gene;Acc:103022360])

HSP 1 Score: 283.493 bits (724), Expect = 3.373e-90
Identity = 156/374 (41.71%), Postives = 225/374 (60.16%), Query Frame = 3 
Query:   81 SELLECIPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRL-DDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRAR 1199
            + + E I    FEYET + V +R+ +VG++ RL QLG+++Y+  WV   EKGYQ  D  +  V  K+KG+A+ N+S     VWDV+D+V P Q   +F V TN +IT  QT   CPE  D    TC SD DC K     TG+G +TG+CV     N T  CEI  WCP E+D   IP  PLL +A N+T+ +KNSI FP+F V R N++  +D+ ++ +C + P+  ++  CPIF+L D+  +S      I   G  I I I+W CNLD+  +KC+P+Y F  L          G+NFR +++Y E+ VEKRTL+K +G++  I V G   KF+       +GSG+ + G+A+V+CDLV+L ++ KRDFYK  +
Sbjct:    3 NSITEAISDFFFEYETPRQVLVRNRRVGVVCRLIQLGVLVYIIGWVFIYEKGYQTEDTAIGSVFTKMKGVAYTNISGEQK-VWDVSDYVYPDQGAESFVVMTNFIITVGQTQSTCPELPDGKN-TCHSDEDCKKGEFKRTGNGEMTGKCV-----NTTNTCEIMSWCPVEDD-RQIPDPPLLLAAENYTLFIKNSITFPEFNVVRSNLVEGVDQNYIKTCMFHPE--KDPLCPIFKLGDIAQYSGFNFTQIAQGGGAIGILIDWECNLDLRIQKCIPKYRFHGLYGSSSEGASVGYNFRKAKYYVEDKVEKRTLMKVFGLRIDIIVHGLARKFDIIPTLTAIGSGVGIFGVATVVCDLVLLYLLPKRDFYKNMK 366
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Cavefish
Match: p2rx1 (purinergic receptor P2X 1 [Source:NCBI gene;Acc:103022360])

HSP 1 Score: 282.722 bits (722), Expect = 4.584e-90
Identity = 156/374 (41.71%), Postives = 225/374 (60.16%), Query Frame = 3 
Query:   81 SELLECIPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRL-DDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRAR 1199
            + + E I    FEYET + V +R+ +VG++ RL QLG+++Y+  WV   EKGYQ  D  +  V  K+KG+A+ N+S     VWDV+D+V P Q   +F V TN +IT  QT   CPE  D    TC SD DC K     TG+G +TG+CV     N T  CEI  WCP E+D   IP  PLL +A N+T+ +KNSI FP+F V R N++  +D+ ++ +C + P+  ++  CPIF+L D+  +S      I   G  I I I+W CNLD+  +KC+P+Y F  L          G+NFR +++Y E+ VEKRTL+K +G++  I V G   KF+       +GSG+ + G+A+V+CDLV+L ++ KRDFYK  +
Sbjct:    3 NSITEAISDFFFEYETPRQVLVRNRRVGVVCRLIQLGVLVYIIGWVFIYEKGYQTEDTAIGSVFTKMKGVAYTNISGEQK-VWDVSDYVYPDQGAESFVVMTNFIITVGQTQSTCPELPDGKN-TCHSDEDCKKGEFKRTGNGEMTGKCV-----NTTNTCEIMSWCPVEDD-RQIPDPPLLLAAENYTLFIKNSITFPEFNVVRSNLVEGVDQNYIKTCMFHPE--KDPLCPIFKLGDIAQYSGFNFTQIAQGGGAIGILIDWECNLDLRIQKCIPKYRFHGLYGSSSEGASVGYNFRKAKYYVEDKVEKRTLMKVFGLRIDIIVHGLARKFDIIPTLTAIGSGVGIFGVATVVCDLVLLYLLPKRDFYKNMK 366
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Cavefish
Match: p2rx4a (purinergic receptor P2X, ligand-gated ion channel, 4a [Source:ZFIN;Acc:ZDB-GENE-020806-2])

HSP 1 Score: 280.411 bits (716), Expect = 3.234e-88
Identity = 164/377 (43.50%), Postives = 227/377 (60.21%), Query Frame = 3 
Query:  114 FEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRY----DPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFD--VGKGWNFRYSEHY-YENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRAR---IDQFQ 1214
            F+Y T K + IRS  VG I RL Q  +I Y+  +V   +KGYQ  D  ++ VT K+KGIA  N S  G  +WDVAD+++PPQ+ ++FFV TN+ IT NQT   CPE+      +C SD DC K       SGV TGRCV        K CE+  WCP E    P P  P+L+ A NFTVL+KNS+ +PKF   RRNIL  ++  +L+ C +    DP       CPIF+L+D++  +    + +  HG ++ + I W+C+LD+    CVP YTFRRLD+ D +  V  G+NFR++++Y   NG E RTLIK YGI+  I V G+ GKFN     +N+G+GL L+G+ +V+CD  VL  +RKR  Y+  +   +D FQ
Sbjct:   80 FDYSTPKTLVIRSKTVGAINRLCQALVIAYIIGYVCVWKKGYQDTDTVISSVTTKVKGIALTNTSDLGTRIWDVADYIIPPQEENSFFVLTNLNITPNQTQSHCPENPGPES-SCSSDQDCKKGFRNGRLSGVRTGRCV--HFSERIKTCEVLAWCPLEKYDEP-PDPPMLAEAENFTVLIKNSVRYPKFNFSRRNILPHINSTYLSKCVFSRDTDPD------CPIFRLRDIVAEAGEDFQAMAVHGGVMGVQIRWDCDLDMPANWCVPRYTFRRLDNKDPENNVAPGYNFRFAKYYKSSNGEEIRTLIKGYGIRFDIMVFGKAGKFNVVPTLLNIGAGLGLMGLVTVVCDWFVLVFMRKRHLYRERKYSYVDDFQ 446
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Cavefish
Match: p2rx4a (purinergic receptor P2X, ligand-gated ion channel, 4a [Source:ZFIN;Acc:ZDB-GENE-020806-2])

HSP 1 Score: 280.026 bits (715), Expect = 2.106e-87
Identity = 164/377 (43.50%), Postives = 227/377 (60.21%), Query Frame = 3 
Query:  114 FEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRY----DPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLD--DFDFDVGKGWNFRYSEHY-YENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRAR---IDQFQ 1214
            F+Y T K + IRS  VG I RL Q  +I Y+  +V   +KGYQ  D  ++ VT K+KGIA  N S  G  +WDVAD+++PPQ+ ++FFV TN+ IT NQT   CPE+      +C SD DC K       SGV TGRCV        K CE+  WCP E    P P  P+L+ A NFTVL+KNS+ +PKF   RRNIL  ++  +L+ C +    DP       CPIF+L+D++  +    + +  HG ++ + I W+C+LD+    CVP YTFRRLD  D + +V  G+NFR++++Y   NG E RTLIK YGI+  I V G+ GKFN     +N+G+GL L+G+ +V+CD  VL  +RKR  Y+  +   +D FQ
Sbjct:   80 FDYSTPKTLVIRSKTVGAINRLCQALVIAYIIGYVCVWKKGYQDTDTVISSVTTKVKGIALTNTSDLGTRIWDVADYIIPPQEENSFFVLTNLNITPNQTQSHCPENPGPES-SCSSDQDCKKGFRNGRLSGVRTGRCV--HFSERIKTCEVLAWCPLEKYDEP-PDPPMLAEAENFTVLIKNSVRYPKFNFSRRNILPHINSTYLSKCVFSRDTDPD------CPIFRLRDIVAEAGEDFQAMAVHGGVMGVQIRWDCDLDMPANWCVPRYTFRRLDNKDPENNVAPGYNFRFAKYYKSSNGEEIRTLIKGYGIRFDIMVFGKAGKFNVVPTLLNIGAGLGLMGLVTVVCDWFVLVFMRKRHLYRERKYSYVDDFQ 446
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Cavefish
Match: p2rx8 (purinergic receptor P2X, ligand-gated ion channel, 8 [Source:ZFIN;Acc:ZDB-GENE-030319-7])

HSP 1 Score: 264.233 bits (674), Expect = 6.153e-83
Identity = 154/381 (40.42%), Postives = 218/381 (57.22%), Query Frame = 3 
Query:   90 LECIPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPV-AGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLD--DFDFDVGKGWNFRYSEHYYEN--GVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQFQK 1217
            L  +  + F+Y+T K V  ++ KVGI+YR+ QL ++ Y+  WV   +KGYQ  +  + + V  K+KG+   N S TG  +W   D+V+P Q     F++TN + T NQ LG C ES  V    C+ + DC +   +  G+GV TGRC+  D +N T  CEIYGWCP E     I   PLL    NFT+ +KN I FPKF   + N+L      +L +C YD     + +CPIF+L D++  S    +++   G  I I IEW+C+LD  Y  C P YTF RLD       V  G+NFRY+ HY++N  G   RTL+K YGI+  I V GR GKFN     +N+GSGLAL+G  S  CD+V+L +++K   Y+  + ++  K
Sbjct:    5 LRAVLLSAFDYKTEKYVIAKNKKVGILYRVIQLSLLGYIIGWVFLTKKGYQETEESIQSSVITKVKGVLLTNSSGTGPRLWGPEDYVIPQQGEDVLFITTNFIETPNQKLGYCAESFKVLDGRCRKNEDCPEGEAVVAGNGVRTGRCLKKD-RNSTGTCEIYGWCPIEKSQRLI--VPLLGKTENFTIYIKNFIRFPKFGFSKSNVLDTAGDSYLKTCLYDA--IAHPYCPIFRLGDIVLRSGHDFQDMALLGGSIGILIEWHCDLDKGYSHCHPRYTFTRLDFNSTANSVSSGYNFRYA-HYFKNPAGETHRTLLKVYGIRFDIQVHGRAGKFNIIPTIINIGSGLALMGAGSFFCDMVLLYMMKKSTLYRERKFEKANK 379
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008095.1 (pep scaffold:Pmarinus_7.0:GL481209:13988:23244:1 gene:ENSPMAG00000007268.1 transcript:ENSPMAT00000008095.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 283.108 bits (723), Expect = 1.200e-90
Identity = 149/373 (39.95%), Postives = 229/373 (61.39%), Query Frame = 3 
Query:  108 TIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDY-PVAGVTAKLKGIAFANLSK-TGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQFQKE 1220
            + FEY+T K++  R   VG++YRL QL I+ Y+  WV  ++KGYQ  D  P   V  K+KG+A  N ++  G  +WD AD+V+PPQ  S FFV TN+V T  Q  G C E+ +V G  C+ D DC   R  +TG+G+ TGRCV ++     +VCE++ WCP EN   P P + +L  A NFTV +K S+ F +F V RRN+L   D  +L SC + P+  R+  CP+F+L +L   + A   ++ T G +I++H+ W+C+LD +   C  +Y F RLD     V  G NFR++ + +++G E R+L+K YG++  + VSG+ GKF+     +NLG+GLALLG  + LCDL +L   ++   Y++ + ++ +++
Sbjct:   12 SAFEYKTEKLMIARDRSVGVVYRLMQLVILAYIIGWVFVVKKGYQETDPDPETSVITKVKGVALTNSTEGPGQRLWDTADYVIPPQGESRFFVVTNLVSTPRQRQGLCAENPNVPGARCQEDGDCPAGRTFNTGNGICTGRCVPTN--GTARVCEVHAWCPVENS--PTPREAVLREAENFTVFIKVSVNFTRFNVHRRNVLEEGDSSYLKSCEFHPE--RSPLCPVFRLGELAVRAGASFSDMATRGGVIAVHLAWDCDLDRDLSACAAQYRFSRLDSERSRVAAGHNFRFARYSWQDGAETRSLLKVYGVRFDVMVSGKAGKFSIVPTLLNLGAGLALLGAGAFLCDLFLLYASKESPQYRQRKFERSEED 378
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008762.1 (pep scaffold:Pmarinus_7.0:GL477338:26903:57888:-1 gene:ENSPMAG00000007911.1 transcript:ENSPMAT00000008762.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 196.823 bits (499), Expect = 1.260e-58
Identity = 115/326 (35.28%), Postives = 179/326 (54.91%), Query Frame = 3 
Query:   99 IPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQT-LGRC--PESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFDVGKGWNFRYSEH-YYENGVEKRTLIKTYGIQCFITVSGR 1064
            +P  IF Y    V+ I +   G I+ + ++ I+ Y A +V+  E  Y+ ++   + V  K+KG A  ++   G   +D AD+VVP Q+ + FFV TN ++T NQT +  C  PE+       C++D DC ++   H GSG+ TGRC+  D     K CE+ GWCP E    P P  PLL +  N TV ++N + F K   +R N    ++ K L+SCRY P+   +  CPIF+L D+   +     ++   G +I+I I W+C L  +  +C P Y+F RLD  ++   +G+NFR   +   E  V+ RTL+K +GI+  I V+G+
Sbjct:    9 LPCNIFFYPRELVIGIENKYCGPIHMVVRIVILGYGARYVVGFEHAYREYEDVTSAVRVKVKGTAKVDIPNEGVRTFDSADYVVPDQEPNTFFVMTNFIVTKNQTQVTTCCNPEAMKFSVSPCQNDGDCTRDASKHLGSGIQTGRCIRYDAT--CKSCEVMGWCPVERRTSP-PQPPLLPATENATVYIQNHVYFIKNNKERENFPLNLEGKDLSSCRYHPRD--DPSCPIFRLGDITAMAGHSFSSMSVQGGIIAIVISWDCKL--SEVECFPAYSFHRLDR-NYTTKRGYNFRSLVYKSMETDVQTRTLVKAFGIRFNILVTGQ 326
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007719.1 (pep scaffold:Pmarinus_7.0:GL477301:21784:46999:1 gene:ENSPMAG00000006964.1 transcript:ENSPMAT00000007719.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 197.208 bits (500), Expect = 1.303e-58
Identity = 134/367 (36.51%), Postives = 190/367 (51.77%), Query Frame = 3 
Query:  114 FEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRY----DPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFD--VGKGWNFRYSEHYYE-NGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKR 1193
              Y  +K  +I+S K  I+  L  + +++    WV+Y   GYQ FD  V+  TAK+KG      ++   +V D AD+V+ P++ ++FFV TN + T NQ  G C E  DV    C SD+DC        G GV TG CV   I N TK CE+  WCP   D  P          P   +L  N+                    +L SCRY    DP+      CPIF L D+++ +    K +   G + SI IEWNCNLD+N + C P Y FRRLD  + +  +  G+NFR+ ++Y +  G+E RTL+K YGI+  + V G+ GK +     ++LGSG+ LLG+  V+CDL+VL   RK   Y+ 
Sbjct:   14 LNYTITKKARIKSRKAAILTFLVFVMLVISYTGWVIYTH-GYQEFDGVVSSSTAKVKG-----ATEVTGMVMDAADYVISPEEPNSFFVMTNFIETPNQKQGACAEDPDV--APCSSDTDCRAGVTDPEGEGVFTGLCV--PINNTTKSCEVNAWCPLPKDSNP----------PKHNILGSNA-------------------SYLKSCRYHRQSDPE------CPIFILGDIVSEAGEDFKELAIEGGVFSIMIEWNCNLDLNEQACKPNYKFRRLDKENRNKTISPGYNFRFPKYYKDAKGIETRTLVKAYGIRFMVEVIGQAGKASLLRSLISLGSGVGLLGMVWVICDLIVLFCCRKSRIYRE 335
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000196.1 (pep scaffold:Pmarinus_7.0:GL482356:953:3300:-1 gene:ENSPMAG00000000176.1 transcript:ENSPMAT00000000196.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 94.3597 bits (233), Expect = 1.751e-23
Identity = 51/114 (44.74%), Postives = 67/114 (58.77%), Query Frame = 3 
Query:  507 GVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGA 848
            G  TGRCV  D   +   CE+  WCP E +     G+ LL SA NFT+L+KN+I FPKF V + N+   MDK FL SC + PKH  N  CPIF L+D++  +    K+I  +G 
Sbjct:    1 GEKTGRCVPFD--KNVSTCEVNAWCPVEVEGKNT-GKRLLRSAENFTILIKNNIRFPKFNVSKGNLPENMDKNFLKSCHHHPKH--NNLCPIFSLRDILRSAGQDFKSIGINGG 109
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Nematostella
Match: EDO41363 (P2X purinoceptor [Source:UniProtKB/TrEMBL;Acc:A7S4Q4])

HSP 1 Score: 307.375 bits (786), Expect = 8.495e-100
Identity = 170/371 (45.82%), Postives = 235/371 (63.34%), Query Frame = 3 
Query:  108 TIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKT-------GAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRAR 1199
            ++ EY TSK+V I+S KVG+I RL QL II Y+  +V+  +KGYQ  + P + VT KLKG +F NL+         G  VWD AD+V+PP++N AFFV+TNMVIT +Q  G CPES D+  V C  D +C +      G G  TG+CV SD +   KVCE++ WCP E D+ P+P  P L    NFTVL+KN+++FP F V +RNI    D   L SC+YD     +  CPIF+L+ +   +      +   G +I I I WNC+ D     C P Y+FRRLD+ +  + KG+NFR++ +Y +N    RTL K YGI+  +TV+G+GGKFN     +NLGSGLALL IA+VLCD+VVL ++R+++FY+  +
Sbjct:   11 SLLEYNTSKIVHIKSKKVGLINRLIQLAIIGYIIGYVIIYKKGYQEVEKPYSSVTTKLKGTSFTNLTGNESFPLYGGPFVWDQADYVIPPEENDAFFVATNMVITPDQRQGTCPESPDIANVKCTRDENCTRMEETSYGHGFQTGKCVPSDQEKGIKVCEVFAWCPVELDITPMPQFPSLK---NFTVLIKNTVQFPSFGVSKRNIAPDADTSTLKSCQYDKD--TSPLCPIFRLETITKEAGQDFNKLAYKGGVIGIIITWNCDFDSLLYSCKPVYSFRRLDNANAPIAKGYNFRHANYYVKNDTLHRTLFKAYGIRFVVTVTGQGGKFNVVPLFLNLGSGLALLSIATVLCDVVVLYVLRRKEFYREKK 376
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Medaka
Match: p2rx1 (purinergic receptor P2X 1 [Source:NCBI gene;Acc:101169631])

HSP 1 Score: 268.855 bits (686), Expect = 1.189e-84
Identity = 150/368 (40.76%), Postives = 223/368 (60.60%), Query Frame = 3 
Query:  114 FEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFR------RLDDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRAR 1199
            FEYET + V +R+ +VG++ RL QLG++ Y+  WV   EKGYQ+ +  V+ V  K+KG+   N+S     VWD +D+V PPQ +S+F V TN ++T NQT+G+CPE    +   CKSD+DC       T  G +TG CV      +TK CE+  WCP E+D   IP  PLL SA NFT+ +KNS+ FP F + R N++  +D K + +C +DP +  +  CPIF+L D++  S    + +   G  I + I+W CN D + +KC P+Y F       R+ D       G+NFRY+++Y  + +EKRTL+K +GI+  I V   G KF+       +GSG+ + G+A+V+CDLV+L ++ +RDFYK  +
Sbjct:   14 FEYETPRQVLVRNKRVGVVCRLIQLGVLAYIIGWVFIYEKGYQITETAVSSVFTKVKGVGSTNISGV-ERVWDPSDYVFPPQGDSSFVVMTNYILTENQTMGKCPELPGRY--ICKSDTDCKGGTYNRTVDGKLTGVCV-----KETKTCELLAWCPLEDD-RNIPNPPLLMSAENFTLFIKNSVTFPLFGITRSNLVEEIDGKTIKNCLFDPDN--SPLCPIFKLGDIVKLSGFTFETMAKQGGAIGLVIDWTCNFDYDVKKCKPKYEFHGLYGNPRVKDTS-KASVGYNFRYAKYYMGDKMEKRTLMKVFGIRFDIIVQSLGRKFDIIPTLTAIGSGVGIFGVATVVCDLVLLYVLPRRDFYKNMK 369
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Medaka
Match: p2rx1 (purinergic receptor P2X 1 [Source:NCBI gene;Acc:101169631])

HSP 1 Score: 269.626 bits (688), Expect = 1.414e-84
Identity = 150/368 (40.76%), Postives = 223/368 (60.60%), Query Frame = 3 
Query:  114 FEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFR------RLDDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRAR 1199
            FEYET + V +R+ +VG++ RL QLG++ Y+  WV   EKGYQ+ +  V+ V  K+KG+   N+S     VWD +D+V PPQ +S+F V TN ++T NQT+G+CPE    +   CKSD+DC       T  G +TG CV      +TK CE+  WCP E+D   IP  PLL SA NFT+ +KNS+ FP F + R N++  +D K + +C +DP +  +  CPIF+L D++  S    + +   G  I + I+W CN D + +KC P+Y F       R+ D       G+NFRY+++Y  + +EKRTL+K +GI+  I V   G KF+       +GSG+ + G+A+V+CDLV+L ++ +RDFYK  +
Sbjct:   14 FEYETPRQVLVRNKRVGVVCRLIQLGVLAYIIGWVFIYEKGYQITETAVSSVFTKVKGVGSTNISGV-ERVWDPSDYVFPPQGDSSFVVMTNYILTENQTMGKCPELPGRY--ICKSDTDCKGGTYNRTVDGKLTGVCV-----KETKTCELLAWCPLEDD-RNIPNPPLLMSAENFTLFIKNSVTFPLFGITRSNLVEEIDGKTIKNCLFDPDN--SPLCPIFKLGDIVKLSGFTFETMAKQGGAIGLVIDWTCNFDYDVKKCKPKYEFHGLYGNPRVKDTS-KASVGYNFRYAKYYMGDKMEKRTLMKVFGIRFDIIVQSLGRKFDIIPTLTAIGSGVGIFGVATVVCDLVLLYVLPRRDFYKNMK 369
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Medaka
Match: p2rx5 (P2X purinoceptor 5 [Source:NCBI gene;Acc:101173001])

HSP 1 Score: 269.626 bits (688), Expect = 5.368e-84
Identity = 155/422 (36.73%), Postives = 239/422 (56.64%), Query Frame = 3 
Query:  108 TIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPV-AGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLD-DFDFDVGKGWNFRYSEHYY-ENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARID--QFQKELYTXXXXXXXXXXXEFVYSKSKLEEKDIYTNSHAQPKEELMVNSIR 1358
            ++  Y+T K V   + ++GI++RL QL ++ Y+  WV  ++KGYQ  +  V   V  K+KG++  N S+TG  +W   D+V+PP     FF+ TN + T NQ LG C ES  V    C+SD DC++   I  G G++TG C+     N T  CEIY WCP E+   P   + LLS A NFT+ +KN I FPKF+  + N+L   D  +L  C YD ++  + +CPIF+L+DL+  +    +++   G  + I IEWNC+LD +  +C P Y+F RLD + +  +  G+NFR++ +Y  E G   RTL K YGI+  I ++G+ GKFN     + +GSG+AL+GI + +CD+++L ++    FY+  + +   F+KE     +      +     SK    EKD   +     K E+MV + R
Sbjct:   10 SLLNYKTEKYVIAENRRIGILFRLYQLAVLGYIIGWVFVVKKGYQEKEEAVQTSVITKVKGVSLINSSQTGPYLWSAEDYVIPPNGEQVFFIVTNYIETPNQRLGFCAESPKVPNGMCQSDEDCLEGESIAAGHGIMTGLCL-----NSTGTCEIYAWCPVEHSKRPT--EALLSEAENFTIYIKNFIRFPKFEFSKSNVLETSDDSYLKKCSYDREN--HPYCPIFRLRDLVRNTGNDFQDMAAKGGSVGILIEWNCDLDKDSSECNPRYSFTRLDMNLNSSITSGYNFRHARYYKDEKGETYRTLYKVYGIRFDIMINGQAGKFNIVPTIIAIGSGVALMGIGAFVCDMILLYMMNTSSFYRERKFEIINFKKERSKTKEGNHRERR-----SKKTAAEKDDANSVKKMDKSEVMVEAAR 417
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Medaka
Match: p2rx4b (purinergic receptor P2X 4 [Source:NCBI gene;Acc:101168548])

HSP 1 Score: 259.61 bits (662), Expect = 3.671e-80
Identity = 151/367 (41.14%), Postives = 229/367 (62.40%), Query Frame = 3 
Query:  111 IFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDF--DVGKGWNFRYSEHY-YENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARI 1202
            +F+YET+K + I  + VGI++R TQL ++LYV  +V  ++KGYQ  D  ++ VT K+KG A+ N S     +WDVAD+V+PPQ +S+FF+ TN+V+T  QT   CPE  +   V CK D DCI+       +G+ TG C   +     K CE++ WCP E D   +P + LL++A NFTVL+KNSI +PKF    RNIL  ++  +L  C ++     +  CPIF+LK +I+ + A  + +   G ++ I I+W+C+LD    KC+P+Y+F RLD+ +   DV  G+NFR+++ Y   +GVE+RTLIK YGI+  + V G  GKF      +NLG+ L+ L +  ++ D V+L  +RKRD Y + ++
Sbjct:   14 VFDYETAKTLVIPHFGVGIVFRFTQLLVVLYVVGYVCVVQKGYQETDSVISTVTTKVKGFAYTNTSDMDPRMWDVADYVIPPQGDSSFFILTNLVVTPEQTQSHCPELPNPSTV-CKDDCDCIEGYNDPRRNGIRTGLC--ENFSTTVKTCEVFSWCPLEVDTR-LPKKALLAAAENFTVLIKNSITYPKFNFHGRNILPHVNSSYLAHCEFN--RLTDPDCPIFRLKRIISEAEADFQEMAVKGGILGILIDWSCDLDWWAGKCLPKYSFHRLDNQNQGNDVAPGYNFRFAKFYKRADGVEERTLIKAYGIRFEVIVFGTAGKFGIVPAIVNLGAALSFLSLVPIVADWVMLTCMRKRDLYTKQKV 374
[Close]
BLAST of p2X purinoceptor 4 vs. Ensembl Medaka
Match: p2rx3b (purinergic receptor P2X 3 [Source:NCBI gene;Acc:101174325])

HSP 1 Score: 245.358 bits (625), Expect = 2.085e-75
Identity = 144/370 (38.92%), Postives = 211/370 (57.03%), Query Frame = 3 
Query:  114 FEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPV-AGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTK-VCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDF--DVGKGWNFRYSEHY-YENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQ 1208
            F YET+K V ++SW +GII R+ QL II Y   WV   EK YQ+ D  + + V  K+KG    N       V DVAD+V P Q  S F + T  + T NQ  G CPES       C +DSDC   R      G++TGRCV     NDTK  CEI GWCP E D + I   P++    NFT+ +KNSI FPKF   + N L  +++ ++  C +D  +  N +CPIF++ D++++++     +   G +I I I W C+LD + E C P Y+F RLD      +V  G+NFR++++Y  ENG + RTLIK Y I+  + V+G  GKFN     +N+ +    +G+ +VLCD+++LN ++  + YK  + ++
Sbjct:    9 FTYETTKSVVVKSWTIGIINRVVQLLIITYFIGWVFLCEKAYQIIDTAIESSVMTKVKGFGVHN-----GQVMDVADYVTPTQGASVFCIITKTITTENQVQGLCPESEKRW--ICYNDSDCNPQRNKPGDYGILTGRCVSF---NDTKKTCEIKGWCPAEIDTVKI--TPMME-VENFTIFIKNSIRFPKFNYTKGNFLPSINRTYIKKCNFDKVN--NTYCPIFRVGDVVHYADQDFSKLADKGGVIGIKISWMCDLDKSDEHCKPSYSFNRLDTMSQKNEVSPGYNFRFAKYYKMENGTDYRTLIKAYAIRFDVIVNGNAGKFNMIPTLINMVAAFTSVGVGTVLCDIILLNFLKGAEQYKAKKFEE 363
[Close]
BLAST of p2X purinoceptor 4 vs. Planmine SMEST
Match: SMESG000010795.1 (SMESG000010795.1)

HSP 1 Score: 922.924 bits (2384), Expect = 0.000e+0
Identity = 497/498 (99.80%), Postives = 498/498 (100.00%), Query Frame = 3 
Query:   69 MKILSELLECIPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQFQKELYTXXXXXXXXXXXEFVYSKSKLEEKDIYTNSHAQPKEELMVNSIRDMXXXXXXXXXXXXXXXXRTSRSSDCILNYNDYFDYSRDTDWNEFLKISKSTEIAWVDEXXXXXXXDY 1562
            MKILSELLECIPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILY+ALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNLGSGLALLGIASVLCDLVVLNIVRKRDFYKRARIDQFQKELYTISKKKIPSSKSEFVYSKSKLEEKDIYTNSHAQPKEELMVNSIRDMKKSPNSNSKNNHNIKNRTSRSSDCILNYNDYFDYSRDTDWNEFLKISKSTEIAWVDESSLSSNSDY
Sbjct:    1 MKILSELLECIPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYIALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNLGSGLALLGIASVLCDLVVLNIVRKRDFYKRARIDQFQKELYTISKKKIPSSKSEFVYSKSKLEEKDIYTNSHAQPKEELMVNSIRDMKKSPNSNSKNNHNIKNRTSRSSDCILNYNDYFDYSRDTDWNEFLKISKSTEIAWVDESSLSSNSDY 498
[Close]
BLAST of p2X purinoceptor 4 vs. Planmine SMEST
Match: SMESG000079250.1 (SMESG000079250.1)

HSP 1 Score: 573.933 bits (1478), Expect = 0.000e+0
Identity = 289/388 (74.48%), Postives = 323/388 (83.25%), Query Frame = 3 
Query:   69 MKILSELLECIPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANL---SKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQFQKEL 1223
            MK  S L   I  +IFEYETSKVVQI+SWK+G IYRL QL IILYV+LWVMY EKGYQ+FDYPVAGVTAKLKGIAFANL   S  G  VWD ADFV+PPQQNSAFFV+TNMVIT NQ+LG C ESTDV+GV C +DS C+ ++ IH GSG+ TG+CV S      KVCEIYGWCPTE+D MP+  + LLSSAPNFTVLLKNSIEF  FK+KRRNIL WMDKKFL SCRY+P H R+KFCPIF+LKD++ +S+AKN+NIWTHG L+SIHIEWNC+LD + E CVPEYTFRRLDDF  DVGKGWNFRYS HY ENG EKRTLIK YGIQ FITVSGRGGKFNPF FSMNLGSGLALLGIASVLCDL VLNIVRKR+ YK+AR+D F+  L
Sbjct:    1 MKKCSVLWNIISESIFEYETSKVVQIKSWKIGFIYRLIQLAIILYVSLWVMYNEKGYQIFDYPVAGVTAKLKGIAFANLTNISSIGMRVWDTADFVIPPQQNSAFFVATNMVITPNQSLGNCDESTDVYGVICVNDSQCVYSKPIHIGSGIQTGKCVESTKIKGIKVCEIYGWCPTEHDRMPLHNRSLLSSAPNFTVLLKNSIEFTAFKIKRRNILKWMDKKFLYSCRYNPHHKRHKFCPIFRLKDIVKYSDAKNQNIWTHGGLMSIHIEWNCDLDFDVENCVPEYTFRRLDDFKEDVGKGWNFRYSYHYVENGTEKRTLIKVYGIQFFITVSGRGGKFNPFKFSMNLGSGLALLGIASVLCDLFVLNIVRKRELYKKARVDSFKSVL 388
[Close]
BLAST of p2X purinoceptor 4 vs. Planmine SMEST
Match: SMESG000044174.1 (SMESG000044174.1)

HSP 1 Score: 568.926 bits (1465), Expect = 0.000e+0
Identity = 283/378 (74.87%), Postives = 319/378 (84.39%), Query Frame = 3 
Query:   99 IPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANL---SKTGAIVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQFQKEL 1223
            +  +IFEYETSKVVQI+SWK+G IYRL QL IILYV+LWVMY EKGYQ+FDYPVAGVTAKLKGIAFANL   S  G  VWD ADFV+PPQQNSAFFV+TNMVIT NQ+LG C ESTDV+GV C +DS C+ ++ IH GSG+ TG+CV S      KVCEIYGWCPTE+D MP+  + LLSSAPNFTVLLKNSIEF  FK+KRRNIL WMD+KFL SCRY+P H R+KFCPIF+LKD++ +S+AKN+NIWTHG L+SIHIEWNC+LD + E CVPEYTFRRLDDF  DVGKGWNFRYS HY ENG EKRTLIK YGIQ FITVSGRGGKFNPF FSMNLGSGLALLGIASVLCDL VLNIVRKR+ YK+AR+D F+  L
Sbjct:   86 LAESIFEYETSKVVQIKSWKIGFIYRLIQLAIILYVSLWVMYNEKGYQIFDYPVAGVTAKLKGIAFANLTNISSIGMRVWDTADFVIPPQQNSAFFVATNMVITPNQSLGNCDESTDVYGVICVNDSQCVYSKPIHIGSGIQTGKCVESTKIKGIKVCEIYGWCPTEHDRMPLHNRSLLSSAPNFTVLLKNSIEFTAFKIKRRNILKWMDRKFLYSCRYNPHHKRHKFCPIFRLKDIVKYSDAKNQNIWTHGGLMSIHIEWNCDLDFDVENCVPEYTFRRLDDFKEDVGKGWNFRYSYHYVENGTEKRTLIKVYGIQFFITVSGRGGKFNPFKFSMNLGSGLALLGIASVLCDLFVLNIVRKRELYKKARVDSFKSVL 463
[Close]
BLAST of p2X purinoceptor 4 vs. Planmine SMEST
Match: SMESG000028996.1 (SMESG000028996.1)

HSP 1 Score: 306.99 bits (785), Expect = 1.772e-99
Identity = 167/383 (43.60%), Postives = 241/383 (62.92%), Query Frame = 3 
Query:   87 LLECIPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGA-IVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDV--MPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQFQKELY 1226
            L  CI + I EYET K+V I++ K+G+I+R  QL I+ YV  +V+  +KGYQ  +  ++ V +K+KG++  N S  G   +WDVAD+V+PPQ+ +AFF+++N +IT  QT G+CPE  +  G  CK+++DC+    I  G GV TG C+      + + CE+Y WCP E+          PLL++  NFTV +KN+IEF KFKV R NI +  +K  L+SCRY   + +   CPIFQ+  ++N +     +I   G +IS  I W+CNLD++ E C P Y+F RLD  D  + KGWNFR++ +YY N  + R LIK YGI+  I+VS + GKF+    +MNLGSGLALL IA+++CD +VL I+R R  Y  A+     +E Y
Sbjct:    7 LRSCI-SVIIEYETVKIVSIKNKKIGLIFRFIQLVILSYVIGYVIVYKKGYQETEPGISAVISKVKGVSLTNRSFAGGETIWDVADYVIPPQEENAFFITSNALITKKQTQGKCPEDKNTVGAQCKTNADCVPLEPIILGDGVKTGVCI------NNQTCEVYAWCPVESSAEDSKTVKLPLLNNVNNFTVYIKNNIEFRKFKVFRSNIPSNFNKSMLSSCRYSSSNTK---CPIFQIGMILNLTGKSYDDILKTGGVISFSINWDCNLDVSLENCFPTYSFNRLDSDDIKLAKGWNFRHANYYYINETQYRDLIKAYGIRFVISVSSKAGKFSIIPLTMNLGSGLALLAIATIICDFIVLYILRNRSKYIEAKYHLIDEEPY 379
[Close]
BLAST of p2X purinoceptor 4 vs. Planmine SMEST
Match: SMESG000028996.1 (SMESG000028996.1)

HSP 1 Score: 299.671 bits (766), Expect = 1.197e-96
Identity = 166/383 (43.34%), Postives = 240/383 (62.66%), Query Frame = 3 
Query:   87 LLECIPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWVMYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGA-IVWDVADFVVPPQQNSAFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVITGRCVLSDIKNDTKVCEIYGWCPTENDV--MPIPGQPLLSSAPNFTVLLKNSIEFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNAKNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFDVGKGWNFRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNXXXXXXXXXXXXXXCDLVVLNIVRKRDFYKRARIDQFQKELY 1226
            L  CI + I EYET K+V I++ K+G+I+R  QL I+ YV  +V+  +KGYQ  +  ++ V +K+KG++  N S  G   +WDVAD+V+PPQ+ +AFF+++N +IT  QT G+CPE  +  G  CK+++DC+    I  G  V TG C+      + + CE+Y WCP E+          PLL++  NFTV +KN+IEF KFKV R NI +  +K  L+SCRY   + +   CPIFQ+  ++N +     +I   G +IS  I W+CNLD++ E C P Y+F RLD  D  + KGWNFR++ +YY N  + R LIK YGI+  I+VS + GKF+    +MNLGSGLALL IA+++CD +VL I+R R  Y  A+     +E Y
Sbjct:    7 LRSCI-SVIIEYETVKIVSIKNKKIGLIFRFIQLVILSYVIGYVIVYKKGYQETEPGISAVISKVKGVSLTNRSFAGGETIWDVADYVIPPQEENAFFITSNALITKKQTQGKCPEDKNTVGAQCKTNADCVPLEPIILG--VKTGVCI------NNQTCEVYAWCPVESSAEDSKTVKLPLLNNVNNFTVYIKNNIEFRKFKVFRSNIPSNFNKSMLSSCRYSSSNTK---CPIFQIGMILNLTGKSYDDILKTGGVISFSINWDCNLDVSLENCFPTYSFNRLDSDDIKLAKGWNFRHANYYYINETQYRDLIKAYGIRFVISVSSKAGKFSIIPLTMNLGSGLALLAIATIICDFIVLYILRNRSKYIEAKYHLIDEEPY 377
The following BLAST results are available for this feature:
BLAST of p2X purinoceptor 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
P2RX47.075e-9444.59purinergic receptor P2X 4 [Source:HGNC Symbol;Acc:... [more]
P2RX46.676e-9042.75purinergic receptor P2X 4 [Source:HGNC Symbol;Acc:... [more]
P2RX43.149e-8944.24purinergic receptor P2X 4 [Source:HGNC Symbol;Acc:... [more]
P2RX54.273e-8737.90purinergic receptor P2X 5 [Source:HGNC Symbol;Acc:... [more]
P2RX5-TAX1BP39.058e-8737.90P2RX5-TAX1BP3 readthrough (NMD candidate) [Source:... [more]
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BLAST of p2X purinoceptor 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of p2X purinoceptor 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of p2X purinoceptor 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
p2rx4a1.049e-9042.89purinergic receptor P2X, ligand-gated ion channel,... [more]
p2rx4a9.886e-8841.92purinergic receptor P2X, ligand-gated ion channel,... [more]
p2rx4a1.278e-8741.92purinergic receptor P2X, ligand-gated ion channel,... [more]
p2rx13.099e-8741.58purinergic receptor P2X, ligand-gated ion channel,... [more]
p2rx13.099e-8741.58purinergic receptor P2X, ligand-gated ion channel,... [more]
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BLAST of p2X purinoceptor 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
p2rx53.640e-9342.02purinergic receptor P2X, ligand gated ion channel,... [more]
p2rx56.825e-9342.09purinergic receptor P2X, ligand gated ion channel,... [more]
p2rx57.191e-9341.87purinergic receptor P2X, ligand gated ion channel,... [more]
p2rx51.193e-9242.25purinergic receptor P2X, ligand gated ion channel,... [more]
ENSXETT00000000163.11.639e-9242.39purinergic receptor P2X, ligand gated ion channel,... [more]
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BLAST of p2X purinoceptor 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
P2rx42.980e-8944.79purinergic receptor P2X, ligand-gated ion channel ... [more]
P2rx49.170e-8543.21purinergic receptor P2X, ligand-gated ion channel ... [more]
P2rx51.669e-8340.32purinergic receptor P2X, ligand-gated ion channel,... [more]
P2rx56.011e-8037.74purinergic receptor P2X, ligand-gated ion channel,... [more]
P2rx35.484e-7938.36purinergic receptor P2X, ligand-gated ion channel,... [more]
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BLAST of p2X purinoceptor 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q99571|P2RX4_HUMAN3.398e-9344.59P2X purinoceptor 4 OS=Homo sapiens OX=9606 GN=P2RX... [more]
sp|P51577|P2RX4_RAT1.385e-8945.04P2X purinoceptor 4 OS=Rattus norvegicus OX=10116 G... [more]
sp|Q5E9U1|P2RX4_BOVIN1.576e-8945.66P2X purinoceptor 4 OS=Bos taurus OX=9913 GN=P2RX4 ... [more]
sp|Q9JJX6|P2RX4_MOUSE4.137e-8844.76P2X purinoceptor 4 OS=Mus musculus OX=10090 GN=P2r... [more]
sp|Q93086|P2RX5_HUMAN2.052e-8637.90P2X purinoceptor 5 OS=Homo sapiens OX=9606 GN=P2RX... [more]
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BLAST of p2X purinoceptor 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0R3T8761.061e-16564.02Uncharacterized protein OS=Rodentolepis nana OX=10... [more]
A0A183AE624.745e-16563.87Uncharacterized protein OS=Echinostoma caproni OX=... [more]
H2KQ331.811e-16464.86p2X purinoceptor 4 OS=Clonorchis sinensis OX=79923... [more]
A0A3R7FR793.291e-16464.86P2X purinoceptor 4 OS=Clonorchis sinensis OX=79923... [more]
A0A075AJT73.669e-16464.86Uncharacterized protein OS=Opisthorchis viverrini ... [more]
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BLAST of p2X purinoceptor 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
p2rx13.373e-9041.71purinergic receptor P2X 1 [Source:NCBI gene;Acc:10... [more]
p2rx14.584e-9041.71purinergic receptor P2X 1 [Source:NCBI gene;Acc:10... [more]
p2rx4a3.234e-8843.50purinergic receptor P2X, ligand-gated ion channel,... [more]
p2rx4a2.106e-8743.50purinergic receptor P2X, ligand-gated ion channel,... [more]
p2rx86.153e-8340.42purinergic receptor P2X, ligand-gated ion channel,... [more]
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BLAST of p2X purinoceptor 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ENSPMAT00000008095.11.200e-9039.95pep scaffold:Pmarinus_7.0:GL481209:13988:23244:1 g... [more]
ENSPMAT00000008762.11.260e-5835.28pep scaffold:Pmarinus_7.0:GL477338:26903:57888:-1 ... [more]
ENSPMAT00000007719.11.303e-5836.51pep scaffold:Pmarinus_7.0:GL477301:21784:46999:1 g... [more]
ENSPMAT00000000196.11.751e-2344.74pep scaffold:Pmarinus_7.0:GL482356:953:3300:-1 gen... [more]
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BLAST of p2X purinoceptor 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of p2X purinoceptor 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO413638.495e-10045.82P2X purinoceptor [Source:UniProtKB/TrEMBL;Acc:A7S... [more]
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BLAST of p2X purinoceptor 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
p2rx11.189e-8440.76purinergic receptor P2X 1 [Source:NCBI gene;Acc:10... [more]
p2rx11.414e-8440.76purinergic receptor P2X 1 [Source:NCBI gene;Acc:10... [more]
p2rx55.368e-8436.73P2X purinoceptor 5 [Source:NCBI gene;Acc:101173001... [more]
p2rx4b3.671e-8041.14purinergic receptor P2X 4 [Source:NCBI gene;Acc:10... [more]
p2rx3b2.085e-7538.92purinergic receptor P2X 3 [Source:NCBI gene;Acc:10... [more]
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BLAST of p2X purinoceptor 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000010795.10.000e+099.80SMESG000010795.1[more]
SMESG000079250.10.000e+074.48SMESG000079250.1[more]
SMESG000044174.10.000e+074.87SMESG000044174.1[more]
SMESG000028996.11.772e-9943.60SMESG000028996.1[more]
SMESG000028996.11.197e-9643.34SMESG000028996.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30023527 ID=SMED30023527|Name=p2X purinoceptor 4|organism=Schmidtea mediterranea sexual|type=transcript|length=1657bp
AATCAAATTCGAACGATCATTGAAAATTTAAATAAACATCACTTATTTCC
GATGAATTTTGTAAAGAAATGAAGATATTAAGTGAGCTTTTAGAATGTAT
ACCCGCAACTATATTTGAATATGAAACTTCGAAAGTCGTTCAAATCAGAT
CGTGGAAGGTTGGTATTATCTATCGGTTAACTCAATTGGGAATAATTCTT
TATGTTGCCTTATGGGTTATGTATTTGGAGAAAGGTTATCAAGTATTCGA
TTATCCAGTAGCAGGAGTTACGGCAAAATTAAAAGGTATTGCTTTTGCTA
ATCTCTCAAAAACTGGAGCTATAGTTTGGGATGTCGCTGATTTTGTCGTG
CCACCTCAGCAGAATTCCGCATTTTTTGTATCAACAAATATGGTAATTAC
TGCCAATCAGACATTAGGTCGTTGTCCTGAATCAACAGATGTTCATGGAG
TAACTTGTAAATCGGATTCAGATTGTATCAAAAACAGAATTATTCATACA
GGAAGCGGTGTCATAACAGGACGTTGTGTTTTATCGGATATAAAGAATGA
TACCAAAGTATGCGAAATTTATGGATGGTGTCCAACTGAAAACGATGTTA
TGCCAATTCCTGGACAACCTTTACTTAGCAGTGCTCCCAATTTTACTGTT
TTATTGAAAAATAGTATTGAATTTCCTAAATTTAAAGTCAAACGTCGCAA
TATTTTGACGTGGATGGATAAAAAATTTCTCAATTCTTGTAGATATGATC
CAAAGCATTGGAGGAATAAATTTTGTCCGATTTTTCAATTAAAAGATTTA
ATCAATTTTTCAAATGCTAAAAATAAAAATATATGGACCCATGGAGCACT
GATTTCCATTCATATAGAATGGAATTGTAATTTGGATATTAACTATGAAA
AATGTGTCCCAGAATACACTTTCCGAAGACTGGATGATTTTGACTTTGAT
GTTGGAAAAGGTTGGAATTTTAGATATTCGGAACACTATTATGAAAATGG
GGTTGAAAAGCGAACATTAATTAAAACATATGGAATCCAGTGTTTTATCA
CAGTTTCTGGTCGAGGAGGAAAATTCAACCCATTTGCATTTTCAATGAAT
TTAGGATCTGGATTAGCATTGTTGGGAATTGCTTCGGTTCTGTGTGATTT
AGTCGTGCTGAATATTGTACGAAAGCGAGATTTCTACAAGCGAGCCAGAA
TCGACCAGTTTCAAAAGGAATTATATACAATCTCCAAAAAGAAAATTCCG
TCATCTAAATCTGAGTTTGTTTATTCAAAATCGAAATTAGAAGAAAAGGA
CATTTATACTAACTCCCATGCGCAACCAAAAGAAGAGTTAATGGTAAATT
CTATTAGAGATATGAAAAAATCACCTAATAGTAATAGTAAAAACAATCAT
AACATAAAAAATAGAACGAGTAGATCCAGTGATTGTATATTAAATTATAA
TGACTATTTTGACTACAGCAGAGATACAGATTGGAATGAGTTCCTAAAGA
TTTCAAAAAGTACGGAAATTGCATGGGTTGATGAATCTTCGCTCAGTAGT
AATAGTGATTATTAAAATTAGATTTTTATTTTATGTTATTCTAATTCATT
TGTTTGTTTGTTATCCAATTCACTTTTATAAATTTTATTTTAATTTTCAA
ACTGGTT
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protein sequence of SMED30023527-orf-1

>SMED30023527-orf-1 ID=SMED30023527-orf-1|Name=SMED30023527-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=499bp
MKILSELLECIPATIFEYETSKVVQIRSWKVGIIYRLTQLGIILYVALWV
MYLEKGYQVFDYPVAGVTAKLKGIAFANLSKTGAIVWDVADFVVPPQQNS
AFFVSTNMVITANQTLGRCPESTDVHGVTCKSDSDCIKNRIIHTGSGVIT
GRCVLSDIKNDTKVCEIYGWCPTENDVMPIPGQPLLSSAPNFTVLLKNSI
EFPKFKVKRRNILTWMDKKFLNSCRYDPKHWRNKFCPIFQLKDLINFSNA
KNKNIWTHGALISIHIEWNCNLDINYEKCVPEYTFRRLDDFDFDVGKGWN
FRYSEHYYENGVEKRTLIKTYGIQCFITVSGRGGKFNPFAFSMNLGSGLA
LLGIASVLCDLVVLNIVRKRDFYKRARIDQFQKELYTISKKKIPSSKSEF
VYSKSKLEEKDIYTNSHAQPKEELMVNSIRDMKKSPNSNSKNNHNIKNRT
SRSSDCILNYNDYFDYSRDTDWNEFLKISKSTEIAWVDESSLSSNSDY*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000101muscle cell
PLANA:0000105secretory cell
PLANA:0000140anterior region of the whole animal
PLANA:0000420parapharyngeal region
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR001429P2X_purnocptor
IPR027309P2X_extracellular_dom_sf
Vocabulary: biological process
TermDefinition
GO:0033198response to ATP
GO:0098655cation transmembrane transport
GO:0035590purinergic nucleotide receptor signaling pathway
GO:0060079excitatory postsynaptic potential
Vocabulary: cellular component
TermDefinition
GO:0005887integral component of plasma membrane
GO:0016020membrane
GO:0016021integral component of membrane
GO:0098794postsynapse
Vocabulary: molecular function
TermDefinition
GO:0004931extracellular ATP-gated cation channel activity
GO:0001614purinergic nucleotide receptor activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001429P2X purinoreceptorPRINTSPR01307P2XRECEPTORcoord: 85..93
score: 63.29
coord: 297..307
score: 45.45
coord: 316..330
score: 48.99
coord: 163..174
score: 63.04
IPR001429P2X purinoreceptorTIGRFAMTIGR00863TIGR00863coord: 11..376
e-value: 1.1E-126
score: 420.6
NoneNo IPR availablePFAMPF00864P2X_receptorcoord: 16..384
e-value: 1.1E-135
score: 452.4
NoneNo IPR availableGENE3DG3DSA:1.10.287.940coord: 39..360
e-value: 6.5E-125
score: 418.4
NoneNo IPR availablePANTHERPTHR10125P2X PURINOCEPTORcoord: 13..389
NoneNo IPR availableTMHMMTMhelixcoord: 31..53
NoneNo IPR availableTMHMMTMhelixcoord: 345..367
IPR027309P2X purinoreceptor extracellular domain superfamilyGENE3DG3DSA:2.60.490.10coord: 59..335
e-value: 6.5E-125
score: 418.4