TTF-type domain-containing protein

Overview
NameTTF-type domain-containing protein
Smed IDSMED30023460
Length (bp)870
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of TTF-type domain-containing protein (SMED30023460) t-SNE clustered cells

Violin plots show distribution of expression levels for TTF-type domain-containing protein (SMED30023460) in cells (dots) of each of the 12 neoblast clusters.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Homology
BLAST of TTF-type domain-containing protein vs. Ensembl Human
Match: THAP12 (THAP domain containing 12 [Source:HGNC Symbol;Acc:HGNC:9440])

HSP 1 Score: 49.6766 bits (117), Expect = 3.580e-6
Identity = 29/111 (26.13%), Postives = 58/111 (52.25%), Query Frame = 3
Query:  162 MFSVVSNETSYISITEQVSIRARFSDVENNLNENFLQFIPVTSTREELA---HSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVHHCTSISDSCQI 485
             FS+++++   I+  E + +  RF D  +NL E F+ F+P  +  E LA   H+++       L+++Y RGQ Y  ++        + +++LEK   A++   ++  SC +
Sbjct:  259 FFSIITDDVVDIAGEEHLPVLVRFVDESHNLREEFIGFLPYEADAEILAVKFHTMITE--KWGLNMEYCRGQAYIVSSGFSSKMKVVASRLLEKYPQAIY---TLCSSCAL 364          
BLAST of TTF-type domain-containing protein vs. Ensembl Zebrafish
Match: CR762475.1 (pep chromosome:GRCz11:4:55494751:55498830:1 gene:ENSDARG00000098243.2 transcript:ENSDART00000172605.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:CR762475.1)

HSP 1 Score: 68.1662 bits (165), Expect = 2.364e-12
Identity = 42/102 (41.18%), Postives = 63/102 (61.76%), Query Frame = 3
Query:  162 MFSVVSNETSYISITEQVSIRARF-SDVENNLNENFLQFIPVTSTR-EELAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVH-HC 458
            +FS++ +ET+ +S  EQVS   R+  D+E  + E FLQ   + ST  +EL + ++  L    LDL  IRGQGYDGAA + G + GLQ++I    + A++ HC
Sbjct:  404 IFSILLDETTDVSHKEQVSFVVRYVRDME--VKERFLQVCTLESTTGKELENVVISLLQDNGLDLKNIRGQGYDGAANMSGMYKGLQSRIRAHNEKALYVHC 503          
BLAST of TTF-type domain-containing protein vs. Ensembl Xenopus
Match: tbx18 (T-box 18 [Source:Xenbase;Acc:XB-GENE-489907])

HSP 1 Score: 73.559 bits (179), Expect = 9.950e-15
Identity = 55/167 (32.93%), Postives = 87/167 (52.10%), Query Frame = 3
Query:   39 KVHLENSSANAICTSD*IQNEIISAFNEIILQSC*KDK*K*MFSVVSNETSYISITEQVSIRARFSDV---ENNLNENFLQFIPVTS-TREELAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVH-HCTS------ISDSCQIREIRNYI 506
            K HL+N+  NA+   D ++  IISA N  +            FSV+++E++ IS  EQ+S+  RF D+      + E FL F  + +     +A+ I++      L++D + GQGYDG + + G   G+QAKI EK   A+  HC S      +++   + EIRN I
Sbjct:  119 KNHLKNAPVNALLCEDILRERIISAANNSV-----------GFSVIADESADISGHEQLSLGVRFVDLTITPVKIREEFLGFATLKAFDATSIANVIMEQCIKFGLNIDKLYGQGYDGCSTMAGKEGGVQAKIKEKYPRAIFVHCASHKLNLVVNNLNAVPEIRNAI 274          

HSP 2 Score: 25.7942 bits (55), Expect = 9.950e-15
Identity = 10/14 (71.43%), Postives = 13/14 (92.86%), Query Frame = 2
Query:    8 FRVDSGDEILKSTL 49
            FR++SGDEILK+ L
Sbjct:  109 FRIESGDEILKNHL 122          
BLAST of TTF-type domain-containing protein vs. Ensembl Xenopus
Match: slc10a6 (solute carrier family 10 (sodium/bile acid cotransporter), member 6 [Source:Xenbase;Acc:XB-GENE-988401])

HSP 1 Score: 69.707 bits (169), Expect = 9.955e-13
Identity = 54/167 (32.34%), Postives = 87/167 (52.10%), Query Frame = 3
Query:   39 KVHLENSSANAICTSD*IQNEIISAFNEIILQSC*KDK*K*MFSVVSNETSYISITEQVSIRARFSDV---ENNLNENFLQFIPVTST-REELAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVH-HCTS------ISDSCQIREIRNYI 506
            K HL+N+  NA  TS  ++NE+I      +L           FSV+++E++ IS  EQ+S+  RF D+      + E FL F  + +     +A+ I++      L++D + GQGYDG + + G   G+QAKI EK   A+  +C S      ++D   + +IRN I
Sbjct:  173 KNHLKNAPVNARYTSVRVENELI------VLSG---------FSVIADESADISGHEQLSLGVRFVDLTITPVKIREEFLGFATLKAVDATSIANVIMEQCIKFGLNMDKLYGQGYDGCSTMAGKEGGVQAKIKEKYPRAIFVYCASHKLNLVVNDLKAVPDIRNAI 324          
BLAST of TTF-type domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000043220.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:7:36411169:36451375:1 gene:ENSXETG00000018966.1 transcript:ENSXETT00000043220.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 55.8398 bits (133), Expect = 3.917e-8
Identity = 40/138 (28.99%), Postives = 73/138 (52.90%), Query Frame = 3
Query:  165 FSVVSNETSYISITEQVSIRARFSDVENNLNENFLQFIP-VTSTREELAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVH-HC---------TSISDSCQIREIRNYIEIFEKAFAFMSTT 545
            +S+  + T  +S T+Q++    +   +    E F++FIP V    E L  +++D+L   ++D+   RGQ YD A+ + G ++GLQA+I +    AV+  C         TS ++SC  RE  ++  I ++ + F S +
Sbjct:  248 YSISVDSTPDVSHTDQLAFIICYVKNDGIPKERFIKFIPNVGHKAENLFSAVMDTLKEYHIDILDCRGQSYDNASNMSGPYSGLQARIKQVNPLAVYIPCSAHSLNLVGTSAAESC--REAVSFFCILQQLYHFFSAS 383          
BLAST of TTF-type domain-containing protein vs. Ensembl Xenopus
Match: thap12 (THAP domain containing 12 [Source:NCBI gene;Acc:394650])

HSP 1 Score: 48.521 bits (114), Expect = 7.850e-6
Identity = 29/109 (26.61%), Postives = 53/109 (48.62%), Query Frame = 3
Query:  162 MFSVVSNETSYISITEQVSIRARFSDVENNLNENFLQFIPVTSTREELAHSILDSL-HSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVHHCTSISDSCQI 485
             FSVV  +   +   E + +  RF D  NNL E FL F+P     + LA +   ++     L++++ RGQ Y  ++ +      + +++LE     VH   ++S +C +
Sbjct:  253 FFSVVMEDAVSLGGEEHMPVFVRFIDETNNLREEFLGFLPCEGDAKALALNFHTTMTEKWGLNMEFCRGQAYVTSSGLSANMKFVASQLLEMYPQVVH---TLSSTCAL 358          
BLAST of TTF-type domain-containing protein vs. Ensembl Mouse
Match: Thap12 (THAP domain containing 12 [Source:MGI Symbol;Acc:MGI:1920231])

HSP 1 Score: 49.2914 bits (116), Expect = 3.876e-6
Identity = 29/109 (26.61%), Postives = 56/109 (51.38%), Query Frame = 3
Query:  162 MFSVVSNETSYISITEQVSIRARFSDVENNLNENFLQFIPVTSTREELAHSILDSL-HSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVHHCTSISDSCQI 485
             FS+++++   I+  E + +  RF D  +NL E F+ F+P  +  E LA     ++     L+++Y RGQ Y  ++        + +++LEK   AV+   ++  SC +
Sbjct:  255 FFSIITDDVVDIAGEEHLPVLVRFVDDAHNLREEFVGFLPYEADAEILAVKFHTTITEKWGLNMEYCRGQAYIVSSGFSSKMKVVASRLLEKYPQAVY---TLCSSCAL 360          
BLAST of TTF-type domain-containing protein vs. TrEMBL
Match: A0A5E4NES0 (Uncharacterized protein OS=Cinara cedri OX=506608 GN=CINCED_3A017282 PE=4 SV=1)

HSP 1 Score: 118.242 bits (295), Expect = 3.462e-26
Identity = 74/182 (40.66%), Postives = 109/182 (59.89%), Query Frame = 3
Query:   51 ENSSANAICTSD*IQNEIISAFNEIIL--------QSC*KDK*K*MFSVVSNETSYISITEQVSIRARFSDVENN-LNENFLQFIPVTS-TREELAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVH-HCT------SISDSCQIREIRNYIEIFEKAFAFMSTT 545
            EN   N   TS  IQNEI+ +  EIIL        ++C        FS+++++TS IS TEQ S+ AR+ D+E+  ++E FL+F+PVT  +   LA +I+D L    ++  Y+RGQGYDGAAA+ G FNG+QA I E   +A++ HC+      SIS +C +  IRN +   E  +AF++T 
Sbjct:  199 ENCGRNVQYTSSQIQNEIVESCFEIILSKIVNKINKNC-------YFSILADKTSDISETEQFSLCARYYDLEDKKIHETFLKFVPVTDLSGRSLAQTIIDELTQLKMNFKYLRGQGYDGAAAMSGKFNGVQAFIRESYYSAIYVHCSAHNLNLSISYACSVPSIRNAMRTIESIYAFLNTP 373          
BLAST of TTF-type domain-containing protein vs. TrEMBL
Match: A0A2L2YQ72 (DUF4371 domain-containing protein (Fragment) OS=Parasteatoda tepidariorum OX=114398 PE=2 SV=1)

HSP 1 Score: 112.464 bits (280), Expect = 4.043e-26
Identity = 72/181 (39.78%), Postives = 110/181 (60.77%), Query Frame = 3
Query:   48 LENSSANAICTSD*IQNEIISAFNEIILQS-C*KDK*K*MFSVVSNETSYISITEQVSIRARFSDVEN-NLNENFLQFIPVTS-TREELAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVH-HCT------SISDSCQIREIRNYIEIFEKAFAFMSTT*RNAV 560
            LE+S  NA  TS   QNE+I   N +ILQ    K      FS++++ET+ I+  EQ+S+  R+ D EN N+ E FLQFIPV   T + +A +ILD L S  +D+  +RGQGYDGAA++ G  NG+QA +   + +A++ HC+      ++S++C+I  IRN +   +  + F++T  R  V
Sbjct:   47 LESSRKNAQYTSPRFQNEVIEVCNILILQKLATKINDATCFSILADETTDIAGIEQLSLCVRYVDKENFNITEQFLQFIPVHDLTGKAIATTILDQLQSMKVDIKKLRGQGYDGAASMSGKINGVQAHVRSIVPSALYVHCSAHSLNLAVSNACEITGIRNCLGTIKTLYDFLNTPKRQYV 227          
BLAST of TTF-type domain-containing protein vs. TrEMBL
Match: A0A2S2P9A7 (Repressor of the inhibitor of the protein kinase OS=Schizaphis graminum OX=13262 GN=PRKRIR_10 PE=4 SV=1)

HSP 1 Score: 114.005 bits (284), Expect = 5.146e-26
Identity = 80/191 (41.88%), Postives = 114/191 (59.69%), Query Frame = 3
Query:   30 KY*KVHLENSSANAICTSD*IQNEIISAFNEIILQS--C*KDK*K*MFSVVSNETSYISITEQVSIRARFSDVE-NNLNENFLQFIPVTS-TREELAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVH-HCT------SISDSCQIREIRNYIEIFEKAFAFMSTT*RNAVYKI 569
            +Y K HL + + NA   S  IQNEI+SA N +ILQ+  C  +K K  FSV+++ETS IS  EQ++I  R+ ++E   + E+FLQF+ VT  + + LA +IL +L    L+L+Y+ GQGYDGAAA+ G FNG Q  I +K   A++ HC       +IS SC + +IRN +   +    F     R  V KI
Sbjct:   69 EYLKSHLTSCAKNATYLSWKIQNEILSACNNLILQNLVCAVNKAK-GFSVLADETSDISNKEQLTICVRYVNLEQKKIREDFLQFVEVTDVSGKALAQTILQNLEIMGLELNYLIGQGYDGAAAMSGKFNGTQKHINDKYPMALYIHCGAHCLNLAISFSCNVTDIRNCMGTMQAICNFFGYPKRQNVLKI 258          
BLAST of TTF-type domain-containing protein vs. TrEMBL
Match: A0A1B6JRW0 (TTF-type domain-containing protein OS=Homalodisca liturata OX=320908 GN=g.13176 PE=4 SV=1)

HSP 1 Score: 118.242 bits (295), Expect = 5.826e-26
Identity = 78/187 (41.71%), Postives = 110/187 (58.82%), Query Frame = 3
Query:   39 KVHLENSSANAICTSD*IQNEIISAFNEIILQS-C*KDK*K*MFSVVSNETSYISITEQVSIRARF--SDVENNLN--ENFLQFIPVTSTR-EELAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVH-HCTS------ISDSCQIREIRNYIEIFEKAFAFMSTT*RNAV 560
            K H E+   NA   S   QN+II A N+II +    K K    FS++++ETS +S  EQ S+  R+  SD  NN    E FL+F+P+TST   ELA +++  L  +N+D++ +RGQGYDGAAA+ G FNG QA I E   TA+  HC S      +S++ ++  IRN   I E+ + F +T  R AV
Sbjct:  265 KKHFESCGKNATYISWNFQNQIIDACNQIITEKIATKVKEAKFFSILADETSDVSTIEQFSLCLRYVDSDASNNYQICEQFLKFMPLTSTTGRELAKTVIKGLEDSNIDVNNLRGQGYDGAAAMSGKFNGTQACIQEAHPTAIFVHCASHSLNLALSNASEVAPIRNCFGIVERVYNFFNTPKRQAV 451          
BLAST of TTF-type domain-containing protein vs. TrEMBL
Match: A0A5N4AYX7 (Uncharacterized protein OS=Photinus pyralis OX=7054 GN=PPYR_04748 PE=4 SV=1)

HSP 1 Score: 115.546 bits (288), Expect = 3.949e-25
Identity = 77/187 (41.18%), Postives = 110/187 (58.82%), Query Frame = 3
Query:   45 HLENSSANAICTSD*IQNEIISAFNEIILQSC*KD-K*K*MFSVVSNETSYISITEQVSIRARF--SDVENNLN--ENFLQFIPVTSTR-EELAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVH-HCTS------ISDSCQIREIRNYIEIFEKAFAFMSTT*RNAVYK 566
            H +N   NA   S  IQNEI++A + +I +    + K    FS++++ETS +S  EQ S+  R+   D E+     E FL+F+PVTST  E LA++I   L   NLD++ +RGQGYDGAA++ G+F G QA+I  K   A++ HC S      +S+S  IR+I+N   I EK   F +T  R AV K
Sbjct:  267 HFQNCGKNATYISWKIQNEILAASHRVIKEKIIAEVKDAKFFSILADETSDVSTMEQFSLCLRYLKRDAESKYTICEKFLEFVPVTSTTGEALANTIETVLRENNLDIENLRGQGYDGAASMSGSFKGTQARIAAKFPKALYVHCASHSLNLALSNSSGIRQIKNCFGIIEKLAVFFNTPKREAVLK 453          
BLAST of TTF-type domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000035789.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000101.1:2843018:2852765:1 gene:ENSAMXG00000037827.1 transcript:ENSAMXT00000035789.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 73.1738 bits (178), Expect = 3.957e-14
Identity = 56/182 (30.77%), Postives = 97/182 (53.30%), Query Frame = 3
Query:   51 ENSSANAICTSD*IQNEIISAFNEIILQSC*KD-K*K*MFSVVSNETSYISITEQVSIRARFSDVENN---------LNENFLQFIPVT-STREELAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVH-HCTS------ISDSCQ-IREIRNYIEIFEKAFAFMS 539
            + S+ N +  S  IQNE+I+  ++ +      + K    +SV+ + T  +S  +Q+S   R+  V  +         +NE+FL F  ++  T + L   I + + S  L L   RGQGYDGA+ + G ++G+Q +IL+K   AV+ HC +      ++D+CQ I EI+ Y +I ++ + F S
Sbjct:   86 KKSNVNYLSPS--IQNELIALLSQRVHDEIVSEIKEAEFYSVIMDTTQDLSKVDQLSQVFRYVTVRKDEADNAIAVDINESFLGFQNISDQTAQGLETKITELIQSKGLPLHKCRGQGYDGASTMSGIYSGVQKRILDKEPNAVYVHCAAHNLNLVLNDACQHITEIKEYYDILQRLYVFFS 265          
BLAST of TTF-type domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000042930.1 (pep primary_assembly:Astyanax_mexicanus-2.0:12:25471427:25473738:-1 gene:ENSAMXG00000037442.1 transcript:ENSAMXT00000042930.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 71.633 bits (174), Expect = 1.231e-13
Identity = 53/169 (31.36%), Postives = 91/169 (53.85%), Query Frame = 3
Query:   90 IQNEIISAFNEIILQSC*KD-K*K*MFSVVSNETSYISITEQVSIRARFSDVENN---------LNENFLQFIPVT-STREELAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVH-HCTS------ISDSCQ-IREIRNYIEIFEKAFAFMS 539
            IQNE+I+  ++ +      + K    +SV+ + T  +S  +Q+S   R+  V  +         +NE+FL F  ++  T + L   I + + S  L L   RGQGYDGA+ + G ++G+Q +IL+K   AV+ HC +      ++D+CQ I EI+ Y +I ++ + F S
Sbjct:  139 IQNELIALLSQRVHDEIVSEIKEAEFYSVIMDTTQDLSKVDQLSQVFRYVTVRKDEADNAIAVDINESFLGFQNISDQTAQGLETKITELIQSNGLLLHKCRGQGYDGASTMSGIYSGVQKRILDKEPNAVYVHCAAHNLNLVLNDACQHITEIKEYYDILQRLYVFFS 307          
BLAST of TTF-type domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000032220.1 (pep primary_assembly:Astyanax_mexicanus-2.0:24:13450075:13452201:1 gene:ENSAMXG00000029800.1 transcript:ENSAMXT00000032220.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 58.151 bits (139), Expect = 3.150e-9
Identity = 48/169 (28.40%), Postives = 87/169 (51.48%), Query Frame = 3
Query:   66 NAICTSD*IQNEIISAFNEIILQSC*KD-K*K*MFSVVSNETSYISITEQVSIRARFSDVENNLNENFLQFIPVTSTREE-LAHSILDSLHSTNLDL-DYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVH-HCTS------ISDSCQ-IREIRNYIEIFEKAFAFMS 539
            NA  TS  IQNE++S   +++     ++ K   +FS++ +ET  +   EQ+S+  R+      ++E+FL F          L   I+  L S  L+  D + GQ YDGA+ + G + G+QA+I E+ + A + HC++      + D+ + + E   +  + E+ + F S
Sbjct:  122 NAKYTSKVIQNEVLSCLADMVRTKIIEEVKDSEVFSIMVDETKDVKKKEQISLVVRYY-FSGAVHESFLHFESADRLDAAGLTDKIIHILQSHGLEYRDNLVGQAYDGASVMSGKYTGVQARIKEQAKHAFYVHCSAHCLNLVLVDTVKTVPEADQFFSLLERLYVFTS 289          
BLAST of TTF-type domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000034915.1 (pep primary_assembly:Astyanax_mexicanus-2.0:4:24766423:24768072:-1 gene:ENSAMXG00000029140.1 transcript:ENSAMXT00000034915.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 56.225 bits (134), Expect = 1.547e-8
Identity = 47/133 (35.34%), Postives = 75/133 (56.39%), Query Frame = 3
Query:   78 TSD*IQNEIISAFNEIILQSC*KDK*K*--MFSVVSNETSYISITEQVSIRARFSDVENNLNENFLQFIPVTSTREELAHSILDSLHSTNLDLD---YIRGQGYDGAAAILGTFNGLQAKILEKLQTAVH-HC 458
            TS  IQN++I+   E+I +S  KD+ K     +V+ +ET+ IS T Q+S+  R+   E+ + E F++F  VT ++   AH I + +     D +    +  Q YDGAA +    NG+QAK+ EK+  A+  HC
Sbjct:  210 TSGTIQNDLINVVAEVIGKSI-KDEIKDAAFTAVMVDETTDISNTTQLSLVLRYV-TEDGIKERFVKFEDVTKSKR--AHDIAELVMKCLEDFECVGKVVAQCYDGAAVMASGLNGVQAKVKEKIPQALFIHC 338          
BLAST of TTF-type domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000044961.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000032.1:419978:423709:1 gene:ENSAMXG00000036481.1 transcript:ENSAMXT00000044961.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 55.0694 bits (131), Expect = 3.494e-8
Identity = 43/133 (32.33%), Postives = 69/133 (51.88%), Query Frame = 3
Query:   45 HLENSSANAICTSD*IQNEIISAF-NEIILQSC*KDK*K*MFSVVSNETSYISITEQVSIRARF--SDVENNLNENFLQFIPVTSTREE-LAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILE 431
             ++N  A     S  IQNEII+   N+++ +   + +    +SV+ + T  IS  EQ+S+  R    D   ++ E+F  FI V  T  + L   +LD L   NL +   RGQ YD  + ++G   G+QA+IL+
Sbjct:  266 RIQNQEAKVHYLSGTIQNEIIALIGNKVLEEIVRRAQRAKYYSVIMDCTPDISHKEQLSVVLRLVNCDPSVSIAEHFFGFIDVEDTSGKGLTEVLLDHLQKHNLSISDCRGQSYDNGSNMMGQKQGVQARILQ 398          
BLAST of TTF-type domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000028133.1 (zinc finger MYM-type protein 1-like [Source:NCBI gene;Acc:111948955])

HSP 1 Score: 54.6842 bits (130), Expect = 5.868e-8
Identity = 41/119 (34.45%), Postives = 64/119 (53.78%), Query Frame = 3
Query:   90 IQNEIISAFNEIILQSC*KD-K*K*MFSVVSNETSYISITEQVSIRARFSDV--ENNLNENFLQFIPVT-STREELAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEK 434
            +QNE+I   +  IL +   D K    FS++ + T  IS TEQ+S+  R   +  +  + E+F+ F+    ST + LA  IL+ L    +  +  RGQ YD  A + G   G+QA++LEK
Sbjct:  339 VQNELIDLLSSKILSAIVDDIKKAKYFSIILDCTLDISHTEQLSVIIRVVSLMEKPQIREHFMGFLEAEESTGQHLASMILNRLEELGISFEDCRGQSYDNGANMKGKNKGVQARLLEK 457          
BLAST of TTF-type domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000042294.1 (zinc finger MYM-type protein 1-like [Source:NCBI gene;Acc:110016639])

HSP 1 Score: 54.6842 bits (130), Expect = 5.868e-8
Identity = 41/119 (34.45%), Postives = 64/119 (53.78%), Query Frame = 3
Query:   90 IQNEIISAFNEIILQSC*KD-K*K*MFSVVSNETSYISITEQVSIRARFSDV--ENNLNENFLQFIPVT-STREELAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEK 434
            +QNE+I   +  IL +   D K    FS++ + T  IS TEQ+S+  R   +  +  + E+F+ F+    ST + LA  IL+ L    +  +  RGQ YD  A + G   G+QA++LEK
Sbjct:  339 VQNELIDLLSSKILSAIVDDIKKAKYFSIILDCTLDISHTEQLSVIIRVVSLMEKPQIREHFMGFLEAEESTGQHLASMILNRLEELGISFEDCRGQSYDNGANMKGKNKGVQARLLEK 457          
BLAST of TTF-type domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000045044.1 (zinc finger MYM-type protein 1-like [Source:NCBI gene;Acc:111948193])

HSP 1 Score: 54.6842 bits (130), Expect = 5.868e-8
Identity = 41/119 (34.45%), Postives = 64/119 (53.78%), Query Frame = 3
Query:   90 IQNEIISAFNEIILQSC*KD-K*K*MFSVVSNETSYISITEQVSIRARFSDV--ENNLNENFLQFIPVT-STREELAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEK 434
            +QNE+I   +  IL +   D K    FS++ + T  IS TEQ+S+  R   +  +  + E+F+ F+    ST + LA  IL+ L    +  +  RGQ YD  A + G   G+QA++LEK
Sbjct:  339 VQNELIDLLSSKILSAIVDDIKKAKYFSIILDCTLDISHTEQLSVIIRVVSLMEKPQIREHFMGFLEAEESTGQHLASMILNRLEELGISFEDCRGQSYDNGANMKGKNKGVQARLLEK 457          
BLAST of TTF-type domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000027735.1 (pep primary_assembly:ASM223467v1:9:30712608:30715295:1 gene:ENSORLG00000030268.1 transcript:ENSORLT00000027735.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 49.2914 bits (116), Expect = 2.911e-6
Identity = 48/171 (28.07%), Postives = 81/171 (47.37%), Query Frame = 3
Query:   66 NAICTSD*IQNEIISAFNEIILQSC*KD-K*K*MFSVVSNETSYISITEQVSIRARFSDVENNLNENFLQFIPVTS-TREELAHSILDSLHSTNLDL-DYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVH-HCTS------ISDSCQ-IREIRNYIEIFEKAFAFMSTT 545
            NA C     QNE+I    E++  S   +      FS++ +ET  +S  EQ+S   R+     ++ E FL F          L+  I++ L    LD  +++ GQ YDGA+ + G   G+QA+I  +   A + HC +      + DS + I E   +  + +K + F+S +
Sbjct:  279 NATCLGHDTQNEMIDCLAEMVRSSITGEVAESEAFSILVDETKDMSKKEQMSFVIRYY-YNGSVCECFLAFEAAQRLNAAALSQKIIEILQKHGLDYKNHLVGQAYDGASVMSGKNTGVQARIKSEAPLAFYVHCNAHCLNLVLVDSVKFIPEANCFFSLLQKLYVFVSGS 448          
BLAST of TTF-type domain-containing protein vs. Planmine SMEST
Match: SMESG000003943.1 (SMESG000003943.1)

HSP 1 Score: 137.117 bits (344), Expect = 5.197e-36
Identity = 84/191 (43.98%), Postives = 120/191 (62.83%), Query Frame = 3
Query:   39 KVHLENSSANAICTSD*IQNEIISAFNEIILQ---------SC*KDK*K*MFSVVSNETSYISITEQVSIRARFSDVENNLNENFLQFIPVTSTREE-LAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVH-HCT------SISDSCQIREIRNYIEIFEKAFAFMSTT*RNAV 560
            K HL+NSS NA   S  IQNE I+A N+IIL+          C        FSV+++ET+ +S  EQ SI  RF D +  +NE+FLQF+PV  T  + L ++++  L S  L+L Y++GQGYDGAAA+ G FN +QAKI++   + ++ HC       S+SD CQI++IRN I + EK ++FM+T  R+AV
Sbjct: 1338 KEHLKNSSKNANYLSWKIQNENINACNQIILKRIVERANQSEC--------FSVLADETTDMSTQEQFSICIRFIDKDKKMNESFLQFVPVVRTSSKSLENTLVQFLSSIGLNLSYLKGQGYDGAAAMSGRFNRVQAKIMDLYPSTLYVHCASHSLNLSLSDVCQIQDIRNCIGVVEKCYSFMNTLKRDAV 1520          
BLAST of TTF-type domain-containing protein vs. Planmine SMEST
Match: SMESG000008969.1 (SMESG000008969.1)

HSP 1 Score: 67.3958 bits (163), Expect = 1.872e-12
Identity = 51/164 (31.10%), Postives = 88/164 (53.66%), Query Frame = 3
Query:   45 HLENSSANAICTSD*IQNEIISAFNEIILQSC*KDK*K*MF-SVVSNETSYISITEQVSIRARF----SDVENNLNENFLQFIPVTSTREE-LAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTA-VHHCTS---------ISDSCQIR 488
            HL++  +NA   S  +QNE+I   N+++ ++  +D  K  F S++++E+  I   EQ+SI  RF    S  E    E FL F+P+     E ++ +I+ SL    LDL  + GQ Y G + + G  +G++ +I ++   A  +HC+S         ++D C+IR
Sbjct:  202 HLQSCPSNATYISHRVQNELIGICNDVLRENIIEDAKKSPFLSIIADESCDIYGIEQLSIGIRFINKMSTNEFCCREEFLGFVPLERMDAEYISETIISSLVKFGLDLSKMVGQAYYGCSTMAGKISGVKKRIQDQYPFANFYHCSSHRLNLVINDLNDVCEIR 365          
BLAST of TTF-type domain-containing protein vs. Planmine SMEST
Match: SMESG000067013.1 (SMESG000067013.1)

HSP 1 Score: 58.5362 bits (140), Expect = 8.951e-10
Identity = 38/142 (26.76%), Postives = 77/142 (54.23%), Query Frame = 3
Query:  162 MFSVVSNETSYISITEQVSIRARFSDVEN-NLNENFLQFIPVTS-TREELAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVH-HCTS------ISDSCQIREIRNYIEIFEKAFAFMSTT*RNAV 560
            +FS+ +++TS  +  EQ++I   + + +   +NE+ L+F+P+   T   ++  I+ ++   N+DL +   Q Y GAA + G  +G+  +I +   +A++ HC S      ++ SC I  +++  E  ++ F F +T  R  V
Sbjct:  135 IFSIYADKTSIRANKEQLAIGVGYFNFDKLEINEDLLKFVPIIDETSNGISSKIMRTVQELNVDLSFCVRQCYGGAAVMKGEKSGVTRRIKDSFPSAIYIHCMSHCLNLALTYSCYIALLKSCTETIKQIFNFFNTPKRQQV 276          
BLAST of TTF-type domain-containing protein vs. Planmine SMEST
Match: SMESG000067013.1 (SMESG000067013.1)

HSP 1 Score: 52.7582 bits (125), Expect = 7.301e-8
Identity = 34/127 (26.77%), Postives = 67/127 (52.76%), Query Frame = 3
Query:  207 EQVSIRARFSDVEN-NLNENFLQFIPVTS-TREELAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVH-HCTS------ISDSCQIREIRNYIEIFEKAFAFMSTT*RNAV 560
            EQ++I   + + +   +NE+ L+F+P+   T   ++  I+ ++   N+DL +   Q Y GAA + G  +G+  +I +   +A++ HC S      ++ SC I  +++  E  ++ F F +T  R  V
Sbjct:  130 EQLAIGVGYFNFDKLEINEDLLKFVPIIDETSNGISSKIMRTVQELNVDLSFCVRQCYGGAAVMKGEKSGVTRRIKDSFPSAIYIHCMSHCLNLALTYSCYIALLKSCTETIKQIFNFFNTPKRQQV 256          
BLAST of TTF-type domain-containing protein vs. Planmine SMEST
Match: SMESG000033201.1 (SMESG000033201.1)

HSP 1 Score: 47.3654 bits (111), Expect = 2.840e-6
Identity = 28/89 (31.46%), Postives = 51/89 (57.30%), Query Frame = 3
Query:  165 FSVVSNETSYISITEQVSIRARFSDVENNLNENFLQFIPVTSTREELAHSILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILE 431
            FS+ SN  S IS T+Q++    +  ++    E FL+F   + T      +IL++  +  +D++  RGQ YD A+ +   ++G+QA+I+E
Sbjct:   21 FSIYSN--SDISHTDQLTFTVHYVKIDGQSVERFLKFQISSHTSLHQFDTILETFRALEIDINDCRGQTYDNASNMSKQYSGVQARIIE 107          
The following BLAST results are available for this feature:
BLAST of TTF-type domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1
Match NameE-valueIdentityDescription
THAP123.580e-626.13THAP domain containing 12 [Source:HGNC Symbol;Acc:... [more]
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BLAST of TTF-type domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TTF-type domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TTF-type domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
CR762475.12.364e-1241.18pep chromosome:GRCz11:4:55494751:55498830:1 gene:E... [more]
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BLAST of TTF-type domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
tbx189.950e-1532.93T-box 18 [Source:Xenbase;Acc:XB-GENE-489907][more]
slc10a69.955e-1332.34solute carrier family 10 (sodium/bile acid cotrans... [more]
ENSXETT00000043220.13.917e-828.99pep primary_assembly:Xenopus_tropicalis_v9.1:7:364... [more]
thap127.850e-626.61THAP domain containing 12 [Source:NCBI gene;Acc:39... [more]
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BLAST of TTF-type domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Thap123.876e-626.61THAP domain containing 12 [Source:MGI Symbol;Acc:M... [more]
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BLAST of TTF-type domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TTF-type domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5E4NES03.462e-2640.66Uncharacterized protein OS=Cinara cedri OX=506608 ... [more]
A0A2L2YQ724.043e-2639.78DUF4371 domain-containing protein (Fragment) OS=Pa... [more]
A0A2S2P9A75.146e-2641.88Repressor of the inhibitor of the protein kinase O... [more]
A0A1B6JRW05.826e-2641.71TTF-type domain-containing protein OS=Homalodisca ... [more]
A0A5N4AYX73.949e-2541.18Uncharacterized protein OS=Photinus pyralis OX=705... [more]
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BLAST of TTF-type domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSAMXT00000035789.13.957e-1430.77pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
ENSAMXT00000042930.11.231e-1331.36pep primary_assembly:Astyanax_mexicanus-2.0:12:254... [more]
ENSAMXT00000032220.13.150e-928.40pep primary_assembly:Astyanax_mexicanus-2.0:24:134... [more]
ENSAMXT00000034915.11.547e-835.34pep primary_assembly:Astyanax_mexicanus-2.0:4:2476... [more]
ENSAMXT00000044961.13.494e-832.33pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
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BLAST of TTF-type domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TTF-type domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TTF-type domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TTF-type domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ENSORLT00000028133.15.868e-834.45zinc finger MYM-type protein 1-like [Source:NCBI g... [more]
ENSORLT00000042294.15.868e-834.45zinc finger MYM-type protein 1-like [Source:NCBI g... [more]
ENSORLT00000045044.15.868e-834.45zinc finger MYM-type protein 1-like [Source:NCBI g... [more]
ENSORLT00000027735.12.911e-628.07pep primary_assembly:ASM223467v1:9:30712608:307152... [more]
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BLAST of TTF-type domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000003943.15.197e-3643.98SMESG000003943.1[more]
SMESG000008969.11.872e-1231.10SMESG000008969.1[more]
SMESG000067013.18.951e-1026.76SMESG000067013.1[more]
SMESG000067013.17.301e-826.77SMESG000067013.1[more]
SMESG000033201.12.840e-631.46SMESG000033201.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30023460 ID=SMED30023460|Name=TTF-type domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=870bp
ACTTAGATTCAGAGTGGATTCTGGAGATGAAATACTGAAAAGTACACTTG
GAAAACTCGTCAGCCAATGCAATATGTACTTCTGACTAAATTCAGAATGA
AATAATTAGTGCTTTCAATGAAATAATCCTACAAAGTTGTTAAAAAGATA
AATAAAAGTAAATGTTTTCTGTTGTTTCTAATGAAACTTCATACATTTCA
ATAACTGAACAAGTTTCAATTCGTGCAAGATTTTCGGATGTAGAAAACAA
TTTAAATGAAAACTTTCTCCAGTTTATTCCTGTGACTTCAACACGAGAAG
AATTAGCACATAGTATTCTTGATTCCCTGCATTCTACTAATTTGGATCTC
GATTACATAAGAGGTCAAGGCTATGATGGTGCAGCAGCAATATTAGGAAC
TTTTAATGGTTTACAAGCTAAAATACTTGAAAAACTTCAAACTGCTGTGC
ATCATTGTACATCAATTTCTGATTCTTGTCAAATTAGAGAAATTCGAAAT
TACATTGAAATATTTGAAAAAGCTTTTGCTTTCATGAGTACTACTTAACG
AAATGCAGTTTATAAGATAGTATAATAAATGTATGTCACACAAGACAAGT
AATAGGCTTCCAATGCTCATTTGCTATTAAACTCAATCAAAACCACAAAG
TTTGTTGTTACTCTCTTTACAATTAAAAAGTTTACTTATACACATTACCT
TGGAGCCAAATGTTGCTGCCCGTTGTCATGACCGAAAACACTGAAGTATA
ACAACAGAGAGAGCACAAATAAACTTGAGTGTATAAATTTTATCTATTTA
ATATTTGTATAGCCTTTGTTAAACAGTTTAATTGTTATTCTTTTATGTCT
AAAATATAGTTACATTGCCT
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protein sequence of SMED30023460-orf-1

>SMED30023460-orf-1 ID=SMED30023460-orf-1|Name=SMED30023460-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=129bp
MFSVVSNETSYISITEQVSIRARFSDVENNLNENFLQFIPVTSTREELAH
SILDSLHSTNLDLDYIRGQGYDGAAAILGTFNGLQAKILEKLQTAVHHCT
SISDSCQIREIRNYIEIFEKAFAFMSTT*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0046983protein dimerization activity
GO:0003676nucleic acid binding
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000070intestinal phagocyte
Vocabulary: INTERPRO
TermDefinition
IPR025398DUF4371
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR025398Domain of unknown function DUF4371PFAMPF14291DUF4371coord: 1..83
e-value: 4.9E-13
score: 49.3
NoneNo IPR availablePANTHERPTHR45749FAMILY NOT NAMEDcoord: 1..97