FMRFamide-activated amiloride-sensitive sodium channel

Overview
NameFMRFamide-activated amiloride-sensitive sodium channel
Smed IDSMED30023310
Length (bp)1981
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of FMRFamide-activated amiloride-sensitive sodium channel (SMED30023310) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for FMRFamide-activated amiloride-sensitive sodium channel (SMED30023310) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30023310

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30023310SMESG000081650.1 SmedASXL_011176SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016
whole organism asexual adult RNA-sequencing evidence
nervous systemSMED30023310SMESG000081650.1 dd_Smed_v4_22997_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30023310SMESG000081650.1 dd_Smed_v4_22997_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30023310SMESG000081650.1 dd_Smed_v6_22997_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1B (sodium channel epithelial 1 beta subunit [Source:HGNC Symbol;Acc:HGNC:10600])

HSP 1 Score: 68.9366 bits (167), Expect = 1.970e-11
Identity = 76/350 (21.71%), Postives = 130/350 (37.14%), Query Frame = 2
Query:  851 YINCHTFIVNKKFTNKT---------FSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCS---KQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHC--NLQTSSEINYQ--NKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            Y NC+ F  N   T K          F ++++L +   D +           +   GVRL LH   +YP I ++GI  M GT T I  +  +   M  P+  C+    +V  +  ++     YS +AC R   Q+ + +NC+C  +      L    + +K C                      D+ +  HC  +LQ S          C   C    Y  TIS A+WP+++          D+I                           +  L ++ ++  N+TL++K            + + +    F+   +EE A+ ++   LS  GG F  W G +  C++
Sbjct:  314 YGNCYIF--NWGMTEKALPSANPGTEFGLKLILDIGQEDYV--------PFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHY------LYPLPRGEKYC-------------------NNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEAS--------EDWI---------------------------FHVLSQERDQSTNITLSRK----------GIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLI 583          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1B (sodium channel epithelial 1 beta subunit [Source:HGNC Symbol;Acc:HGNC:10600])

HSP 1 Score: 68.5514 bits (166), Expect = 2.033e-11
Identity = 76/350 (21.71%), Postives = 130/350 (37.14%), Query Frame = 2
Query:  851 YINCHTFIVNKKFTNKT---------FSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCS---KQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHC--NLQTSSEINYQ--NKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            Y NC+ F  N   T K          F ++++L +   D +           +   GVRL LH   +YP I ++GI  M GT T I  +  +   M  P+  C+    +V  +  ++     YS +AC R   Q+ + +NC+C  +      L    + +K C                      D+ +  HC  +LQ S          C   C    Y  TIS A+WP+++          D+I                           +  L ++ ++  N+TL++K            + + +    F+   +EE A+ ++   LS  GG F  W G +  C++
Sbjct:  242 YGNCYIF--NWGMTEKALPSANPGTEFGLKLILDIGQEDYV--------PFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHY------LYPLPRGEKYC-------------------NNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEAS--------EDWI---------------------------FHVLSQERDQSTNITLSRK----------GIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLI 511          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1B (sodium channel epithelial 1 beta subunit [Source:HGNC Symbol;Acc:HGNC:10600])

HSP 1 Score: 68.5514 bits (166), Expect = 2.233e-11
Identity = 76/350 (21.71%), Postives = 130/350 (37.14%), Query Frame = 2
Query:  851 YINCHTFIVNKKFTNKT---------FSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCS---KQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHC--NLQTSSEINYQ--NKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            Y NC+ F  N   T K          F ++++L +   D +           +   GVRL LH   +YP I ++GI  M GT T I  +  +   M  P+  C+    +V  +  ++     YS +AC R   Q+ + +NC+C  +      L    + +K C                      D+ +  HC  +LQ S          C   C    Y  TIS A+WP+++          D+I                           +  L ++ ++  N+TL++K            + + +    F+   +EE A+ ++   LS  GG F  W G +  C++
Sbjct:  269 YGNCYIF--NWGMTEKALPSANPGTEFGLKLILDIGQEDYV--------PFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHY------LYPLPRGEKYC-------------------NNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEAS--------EDWI---------------------------FHVLSQERDQSTNITLSRK----------GIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLI 538          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1G (sodium channel epithelial 1 gamma subunit [Source:HGNC Symbol;Acc:HGNC:10602])

HSP 1 Score: 53.5286 bits (127), Expect = 1.000e-6
Identity = 52/244 (21.31%), Postives = 100/244 (40.98%), Query Frame = 2
Query:  800 GIVCDKAGHWVSTLNSIYINCHTF-------IVNKKFTNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQ-----TSSEINYQNKCNSPCTFFTYDTTISSAEWPT 1495
            G+ CD A ++    + ++ NC+TF       I++       + ++V+LY++  +E Y    N   + S  TG ++ +H    YP + + G  +    +T I     +   +  P+ +C++  S     N     YS + C     Q ++ + C C  ++Q                  P  P +N      N+ Q  +++   +C  Q        E+  Q+ C   C+F  +  T S A+WP+
Sbjct:  264 GVSCD-ARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYIN--EEEY----NPFLVSS--TGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQ------------------PLPPAANYC----NYQQHPNWM---YCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPS 473          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1A (sodium channel epithelial 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:10599])

HSP 1 Score: 51.9878 bits (123), Expect = 2.042e-6
Identity = 67/342 (19.59%), Postives = 116/342 (33.92%), Query Frame = 2
Query:  848 IYINCHTFIVNKKFTNKTFSMEVVLYLDHADEIY--CNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCV-DFNQVPDDLN--NYLQHKK--ICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            +Y NC+TF  N K  N    M  +  +++   +       + + + S +TG R+ +H       + + G NL PG  T I       + +   +G C+K  S     N    +Y+++ C     QE + K C C   F   P ++   +Y +H     C Y     FS+  L  F                          KC  PC+  +Y  +   + WP+                            T   W            + + + ++ N T+N K         N    + +     +     E  SV++   LS  G  +S+W G +   +V
Sbjct:    1 MYGNCYTF--NDK-NNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCF-------------------------TKCRKPCSVTSYQLSAGYSRWPSV---------------------------TSQEW------------VFQMLSRQNNYTVNNK--------RNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVV 267          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: del-4 (DEgenerin Like [Source:UniProtKB/TrEMBL;Acc:P91835])

HSP 1 Score: 68.1662 bits (165), Expect = 9.457e-12
Identity = 89/419 (21.24%), Postives = 162/419 (38.66%), Query Frame = 2
Query:  281 WSAISKHWKVFCETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNIN-SYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKT----FSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNAT---LSSFNHSQTADYLNKTH-CNLQTSSEINYQNKCN--SPCTFFTYDTTISSAEWPTKSF 1504
            W+ +   +  F   TS  GVP I        R  WI  V       I   + L+  Y  + V  +    + + T FP+++ C+L P      K++  + ++++ +       S +    +S   +R+     W +  S  LN        D+ +   +MV+ C        YN+   C+    +    N  Y NC  F  +  +++      + + +V+  D          +    +++ +GV +++H     P     G    PGT + +     Q   +  P+G C+ +   K +       Y+ EAC R  +QE++  +C C                     Y PA   ++ T   +S  N  QT   LN     N   S+E +    C+   PC   +Y  T+S+A+WP+ S+
Sbjct:    5 WTGLKYVFTDFSCWTSTHGVPHIGMANARWLRAFWILVVVVSIALFIWQFITLLTNYLSFSVNTETTLQFAERT-FPTVTICHLNPWKLSETKSVDPD-MSALIDAYNSDSSSAQFGLPASLTADRQQQASKWTLMYSERLNEKQYNDAADIAYSYDDMVVSC-------TYNAK-TCNIT-DFNDFYNPSYGNCLQFNTDGMYSSSRAGPLYGLRMVMRTDQ---------DTYLPWTEASGVIIDIHMQDEIPYPDVFGYFAPPGTASSLGVSYVQTTRLSKPYGSCTTKTKLKTT--HYTGTYTVEACFRSCMQEKIIASCGC---------------------YYPAYSHASNTTQYVSCDNGVQTLSNLNCVDLINSADSTEFDVLTDCDCPQPCEIDSYGVTVSTAQWPSDSY 380          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: asic-2 (Degenerin-like protein asic-2 [Source:UniProtKB/Swiss-Prot;Acc:Q22851])

HSP 1 Score: 59.3066 bits (142), Expect = 5.327e-9
Identity = 104/528 (19.70%), Postives = 191/528 (36.17%), Query Frame = 2
Query:  302 WKVFCETTSLRGVPRIAKTRDPKRRFLWI---FFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNINSYFLNLPNST----QPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKTFSMEVVLY----LDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            +K F   +++  VP +A   +   R  WI    FV   F      + +LI ++  Y      + ++ K   FP ++ CN+ P     +K+      NS    +  L  +  D    +  T++  L    N  +Y L+   +     + N +        +Y      Q    +GI C ++  +   ++ +Y  C++F  +    N + S E + +    +    +   N   +    ++L G R+ ++S G+ P +   GI+   G  + +     Q    + P+G C  +      + K +F Y+ E C     Q +    C C +        +        CQ + A      TL     S T +      CN            CN PC   TY  T+S A++P+ S+          Y+            ST S +++  +  K Y                          +NN + IQV        L  E A  +++N ++  GG   +W G++   +V
Sbjct:   10 FKDFSNWSTVAVVPHVANANNKISRIFWIAIFLFVLGMF---AYELYILIAKFFSYPATVNTEILFEKQI-FPVVTVCNMNPYKYSVVKS------NSAFSSVNTLMTTYSDATVGTFSTDKWGLYAD-NDETYDLDSRAADALVLEANLISDTAKVPALYTYADLIQDCSFAGIPCSES-DFTKFIDPVYGACYSFNEDASL-NYSVSREGIQFGLKLMLTVTQTKTNGNTDSLPTTKLAGARIGVNSRGSSPGLDSNGIDAGVGYESAVSVSLTQNVRAKKPYGTCVDREPDSSDYYK-DFIYTLETCFNGCKQRDTIAKCQCANPRLALGSTDT------ACQPIKADLDCLQTLKGNQTSSTPNIDLLVECN------------CNPPCDESTYTPTVSLAQFPSTSY----------YVATSSTAGVGSCSSTNSKFSSKSDCQKWY--------------------------NNNGMIIQVFLETLSYELYTETAGYTVSNVINDLGGQAGLWLGLSVISVV 469          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: unc-105 (Degenerin-like protein unc-105 [Source:UniProtKB/Swiss-Prot;Acc:Q09274])

HSP 1 Score: 59.3066 bits (142), Expect = 7.089e-9
Identity = 52/237 (21.94%), Postives = 90/237 (37.97%), Query Frame = 2
Query:  842 NSIYINCHTFIVNKKF------TNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTS---SEINYQNK--------CNSPCTFFTYDTTISSAEWPTKS 1501
            ++ + NC+TF  N+            + + V+LY +          +E    ++  G R+ +H     P     G +   G ++      +Q+  +EPP+G C        +F    FQYS EAC R   Q+ + + C C D                     P  P +    ++    Q  + +++  C   T+    E+  + K        C+ PC    Y+ T SSA WP+ S
Sbjct:  400 DNTFGNCYTFNYNRTAEVASHRAGANYGLRVLLYAN---------VSEYLPTTEAVGFRITVHDKHIVPFPDAFGYSAPTGFMSSFGVRMKQFIRLEPPYGHCRHGGEDAATFVYTGFQYSVEACHRSCAQKVIVEACGCAD---------------------PMYPVAEMFGNNTKPCQAVN-MDQRECLRNTTLWLGELYSKGKEAIIPDCYCHQPCQETNYEVTYSSARWPSGS 605          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: unc-105 (Degenerin-like protein unc-105 [Source:UniProtKB/Swiss-Prot;Acc:Q09274])

HSP 1 Score: 59.3066 bits (142), Expect = 7.089e-9
Identity = 52/237 (21.94%), Postives = 90/237 (37.97%), Query Frame = 2
Query:  842 NSIYINCHTFIVNKKF------TNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTS---SEINYQNK--------CNSPCTFFTYDTTISSAEWPTKS 1501
            ++ + NC+TF  N+            + + V+LY +          +E    ++  G R+ +H     P     G +   G ++      +Q+  +EPP+G C        +F    FQYS EAC R   Q+ + + C C D                     P  P +    ++    Q  + +++  C   T+    E+  + K        C+ PC    Y+ T SSA WP+ S
Sbjct:  400 DNTFGNCYTFNYNRTAEVASHRAGANYGLRVLLYAN---------VSEYLPTTEAVGFRITVHDKHIVPFPDAFGYSAPTGFMSSFGVRMKQFIRLEPPYGHCRHGGEDAATFVYTGFQYSVEACHRSCAQKVIVEACGCAD---------------------PMYPVAEMFGNNTKPCQAVN-MDQRECLRNTTLWLGELYSKGKEAIIPDCYCHQPCQETNYEVTYSSARWPSGS 605          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: unc-105 (Degenerin-like protein unc-105 [Source:UniProtKB/Swiss-Prot;Acc:Q09274])

HSP 1 Score: 59.3066 bits (142), Expect = 7.146e-9
Identity = 52/237 (21.94%), Postives = 90/237 (37.97%), Query Frame = 2
Query:  842 NSIYINCHTFIVNKKF------TNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTS---SEINYQNK--------CNSPCTFFTYDTTISSAEWPTKS 1501
            ++ + NC+TF  N+            + + V+LY +          +E    ++  G R+ +H     P     G +   G ++      +Q+  +EPP+G C        +F    FQYS EAC R   Q+ + + C C D                     P  P +    ++    Q  + +++  C   T+    E+  + K        C+ PC    Y+ T SSA WP+ S
Sbjct:  380 DNTFGNCYTFNYNRTAEVASHRAGANYGLRVLLYAN---------VSEYLPTTEAVGFRITVHDKHIVPFPDAFGYSAPTGFMSSFGVRMKQFIRLEPPYGHCRHGGEDAATFVYTGFQYSVEACHRSCAQKVIVEACGCAD---------------------PMYPVAEMFGNNTKPCQAVN-MDQRECLRNTTLWLGELYSKGKEAIIPDCYCHQPCQETNYEVTYSSARWPSGS 585          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Zebrafish
Match: asic1b (acid-sensing (proton-gated) ion channel 1b [Source:NCBI gene;Acc:407672])

HSP 1 Score: 51.2174 bits (121), Expect = 2.994e-6
Identity = 63/277 (22.74%), Postives = 105/277 (37.91%), Query Frame = 2
Query:  485 VYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLK------QLKQSMEDLRKSSNITERKLLTMSWNINS------YFLNLPNSTQP------NDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKF------TNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDC 1243
            VY K   FP+++ CN   L     + +K   + S   +L       Q+  ++ D   S  + +   +   W+  S      +FL  P  +QP      + LGH   EM++YC           G +C       ST+ + Y  C+TF   +        T       + + LD   + Y     E    +   G+++ +H+    P I + G  + PG  T +    ++   + PP G C         FN     YS  AC+       L +NC+C
Sbjct:   81 VYAKRLVFPAVTICNKNILLP---RRMKKPDIFSAGRWLGIFGKNWQVSAAVRDALAS--LDDGTNVDPPWSPFSRILEFNHFLPPPRDSQPSMRQLLDRLGHQLEEMLLYCRF--------QGQLCGPRN--FSTIFTRYGKCYTFNSGQDGRPLLITTKGGMGNGLEIMLDIQQDEYLPVWGETDETTFEAGIKVQIHTQDEPPFIDQLGFGVAPGFQTFVSCQEQRLTYLPPPWGDCKATPIDSDFFNT----YSITACRIDCETRYLVENCNC 338          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Zebrafish
Match: asic1c (acid-sensing (proton-gated) ion channel 1c [Source:NCBI gene;Acc:407670])

HSP 1 Score: 50.0618 bits (118), Expect = 6.627e-6
Identity = 73/327 (22.32%), Postives = 127/327 (38.84%), Query Frame = 2
Query:  305 KVFCETTSLRGVPRI-AKTRDPKRRFLWIF-FVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNINSYFLNLPNSTQPNDL----GHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTF--------IVNKKFTNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDC 1243
            +VF   ++L G+  I A      RRFLW   F+ +  L    C+   +  Y ++  + +   V      FP+++FCNL   +      +  N L  V E L  L ++ +    + ++ + ++LT+     S+    P      D     GHD  EM++ C           G  C       +T+ + Y  C+TF        ++          +E++L  D   + Y     +    S   G+++ +HS    P I + G  + PG  T +    +    + PP G C         F+     YS  AC+       L +NC+C
Sbjct:   21 QVFANNSTLHGMSHIFAYGHMTFRRFLWTLSFMGSLGLLMYVCMDR-VYYYFEFPHVTKLDEVAAPNLTFPAVTFCNL---NEFRFSKITKNDLYHVGELLALLNENYQ--IANPHLADPEVLTLLKEKASFNGFKPKQFNMTDFYNRTGHDINEMLLQCSF--------RGEECFPLN--FTTIYTRYGKCYTFNSGLDGNPLLTTLKGGTGNGLEIML--DIQQDEYLPVWGDTDETSYEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQQQLLLYLPPPWGDCRSAPMDSEYFST----YSITACRIDCETRYLLENCNC 325          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: scnn1b (sodium channel, non voltage gated 1 beta subunit [Source:NCBI gene;Acc:779891])

HSP 1 Score: 66.2402 bits (160), Expect = 1.198e-10
Identity = 69/349 (19.77%), Postives = 126/349 (36.10%), Query Frame = 2
Query:  842 NSIYINCHTFIVNKKFTN--------KTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGV-RLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCS---KQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            ++ Y NC+ F   ++  +          F +++VL ++           E   Y Q T   RL LH   ++P + + GI  MPGT T I  +  Q   ME P+  C+     +  +  + +    YS ++C R   QE++ + C C D+     + + Y  + K   ++P             +       ++  C           + C  PC    Y   IS A+WP+           +D+I                           +  L  + +   N+T+N+          N  + + +    F+   + E  + ++   LS  GG F  W G +  CI+
Sbjct:  284 DADYGNCYIFNWGQEGEDPMASANPGADFGLKLVLDIEQG---------EYLPYVQTTAAARLILHQQRSFPFVKDLGIYAMPGTETSIAVLVDQLEHMEAPYSSCTVNGSDIPVQNLYAEFNSSYSIQSCLRSCYQEQMVQTCGCADYQYPLPNGSEYCSNDKYPDWVPCY-----------YGLRDSVADRESC----------ISLCQQPCNDTQYKMVISMADWPS--------AGAQDWI---------------------------FHVLSYEKDSSHNITVNR----------NGIVRLNIYFQEFNYRSITESEATNVVWLLSNLGGQFGFWMGGSVLCII 557          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: cldn16 (claudin 16 [Source:Xenbase;Acc:XB-GENE-971823])

HSP 1 Score: 64.3142 bits (155), Expect = 3.946e-10
Identity = 97/492 (19.72%), Postives = 173/492 (35.16%), Query Frame = 2
Query:  281 WSAISKHWKVFCETTSLRGVPRIAKTRDPKRR-FLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNINSYFLNLPNSTQ---PNDLGHDRLEMVMYCLLIYKQGIYNSGI-VCDKAG---------------------HWVSTL-------------------------------------NSIYINCHTFIVNKKFTNKTFS---------MEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVP----DDLNNYLQHKKI--CQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLK 1522
            +S+  + ++ FC  T++ G  R+  +R  + +   W+    A F        LL  QY  Y V        +K  PFP+++ C L P    +I+       N + E  K+ ++++ +L K ++   +  +  +  +      LP+  +   P    H     V+   L  K+  +N G  +C++ G                     H+++ L                                     ++IY NC+TF  N+   +  +S         + ++L  +  D I         + S + G R+ +H       + + G N+ PG  T I       N M   +  CS+  S     N  E +Y+E+ C R   Q  + + C C  +   P    D+  +Y +HK    C Y     F++  L  F                         +KC  PC    Y  T   ++WP +     F K
Sbjct:   16 FSSYRELFEFFCSNTTIHGAIRLVCSRSNRMKTAFWLVLFLATFGLMYWQFGLLFGQYFSYPVSINLNVNSDK-LPFPAVTVCTLNPYRYKAIQ-------NDLQELDKETQRTLYELYKYNSTGVQGWIPTNQRVRRDRPGLPHLLELVPPGSKTHRVSRSVIEEELQVKRREWNIGFKLCNETGGDCFYQTYTSGVDAIREWYRFHYINILARVPEEAAIDGEQLENFIFACRFNEESCTKANYSHFHHAIYGNCYTFNQNRSGQSNLWSSSMPGIKNGLTLILRTEQHDYI--------PLLSSVAGARVLVHGHKEPAFMDDSGFNIPPGMETSIGMKKETVNRMGGKYSDCSEDGSDVDVKNLFESEYTEQVCVRSCFQAAMVERCGC-GYAFYPLSPGDEFCDYNKHKSWGHCYYKLIIEFTSNKLGCF-------------------------SKCRKPCLVSEYQLTAGYSKWPNRVSQPRFWK 465          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: lhx1 (LIM homeobox 1 [Source:Xenbase;Acc:XB-GENE-482482])

HSP 1 Score: 62.3882 bits (150), Expect = 6.448e-10
Identity = 60/274 (21.90%), Postives = 118/274 (43.07%), Query Frame = 2
Query:  317 ETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIK---TLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWN-INSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKTFSMEV---------VLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQ 1099
            + TS  G+P I +++   RR +W+ FV+      +     +++ Y  Y    +   + +    FP+++ CNL  +   S+    ++ N+  +S  E   +  +S      S ++ E  L   ++N   S F  LP+  Q  ++GH   +M+++C           G  C+ +  +   +N  + NC+TF   K    +   + V          +Y  H  E++      ++  +   G+RL +H     P   ++G+N+ PG  TEI  +  Q
Sbjct:   36 QHTSAHGIPNIFRSKHWFRRMVWLVFVSFALCCALWQCTQMVLTYYTYPSHEKIMLISSAKLKFPAVTICNLNSVRLSSLGRSFSMSNSLQDSGLEMTHRRNRSHHMNVTSDSVDENVLYASAFNKFASEFNQLPDE-QKIEMGHQLEDMLIFCNF--------HGQECNSS-FFSGFINYKFGNCYTFNSQKSVDIRGNQIRVDPLNITKAGFMYGLHL-ELFIQQIEYVRDMTHAAGIRLLVHDQAQMPFPEDEGVNVPPGAETEIGMMKVQ 298          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: scnn1b (sodium channel, non voltage gated 1 beta subunit [Source:NCBI gene;Acc:779891])

HSP 1 Score: 61.2326 bits (147), Expect = 3.386e-9
Identity = 49/205 (23.90%), Postives = 81/205 (39.51%), Query Frame = 2
Query:  977 YSQLTGV-RLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCS---KQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITES 1579
            Y Q T   RL LH   ++P + + GI  MPGT T I  +  Q   ME P+  C+     +  +  + +    YS ++C R   QE++ + C C D+     + + Y  + K   ++P             +       ++  C           + C  PC    Y   IS A+WP+           ++   K   N+ +ITES
Sbjct:  297 YVQTTAAARLILHQQRSFPFVKDLGIYAMPGTETSIAVLVDQLEHMEAPYSSCTVNGSDIPVQNLYAEFNSSYSIQSCLRSCYQEQMVQTCGCADYQYPLPNGSEYCSNDKYPDWVPCY-----------YGLRDSVADRESC----------ISLCQQPCNDTQYKMVISMADWPS--------AGAQEIWDKHDFNYRSITES 472          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: cldn16 (claudin 16 [Source:Xenbase;Acc:XB-GENE-971823])

HSP 1 Score: 58.9214 bits (141), Expect = 2.041e-8
Identity = 55/246 (22.36%), Postives = 92/246 (37.40%), Query Frame = 2
Query:  842 NSIYINCHTFIVNKKFTNKTFS---------MEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVP----DDLNNYLQHKKI--CQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRD 1534
            ++IY NC+TF  N+   +  +S         + ++L  +  D I         + S + G R+ +H       + + G N+ PG  T I       N M   +  CS+  S     N  E +Y+E+ C R   Q  + + C C  +   P    D+  +Y +HK    C Y     F++  L  F                         +KC  PC    Y  T   ++WP +    S+ +  +D
Sbjct:  301 HAIYGNCYTFNQNRSGQSNLWSSSMPGIKNGLTLILRTEQHDYI--------PLLSSVAGARVLVHGHKEPAFMDDSGFNIPPGMETSIGMKKETVNRMGGKYSDCSEDGSDVDVKNLFESEYTEQVCVRSCFQAAMVERCGC-GYAFYPLSPGDEFCDYNKHKSWGHCYYKLIIEFTSNKLGCF-------------------------SKCRKPCLVSEYQLTAGYSKWPNRVSQVSWPRFWKD 512          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Scnn1b (sodium channel, nonvoltage-gated 1 beta [Source:MGI Symbol;Acc:MGI:104696])

HSP 1 Score: 63.929 bits (154), Expect = 4.933e-10
Identity = 75/350 (21.43%), Postives = 125/350 (35.71%), Query Frame = 2
Query:  851 YINCHTFIVNKKFTNKT---------FSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCS---KQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDT----TISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            Y NC+ F  N   T +T         F ++++L +   D +           +   G RL LH   TYP I E+GI  M GT T I  +  +      P+  C+     V+ K  ++     YS +AC     Q+ + +NC C  +      L    + +K C                      D+ +  +C L     +  +  C S C     DT    TIS A+WP+++     L  L    Q+R                                ++  N+TL++K            + + +    F+   +EE  + ++   LS  GG F  W G +  C++
Sbjct:  267 YGNCYIF--NWGMTEETLPSANPGTEFGLKLILDIGQEDYV--------PFLASTAGARLMLHEQRTYPFIREEGIYAMAGTETSIGVLVDKLQRKGEPYSPCTMNGSDVAIKNLYSVYNTTYSIQACLHSCFQDHMIRNCSCGHY------LYPLPEGEKYC-------------------NNRDFPDWAYCYLNLQMSVTQRETCLSMCKESCNDTQYKMTISMADWPSEASEDWILHVLS---QER--------------------------------DQSSNITLSRK----------GIVKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLI 536          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Scnn1b (sodium channel, nonvoltage-gated 1 beta [Source:MGI Symbol;Acc:MGI:104696])

HSP 1 Score: 56.225 bits (134), Expect = 8.447e-8
Identity = 56/233 (24.03%), Postives = 89/233 (38.20%), Query Frame = 2
Query:  851 YINCHTFIVNKKFTNKT---------FSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCS---KQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDT----TISSAEWPTKS 1501
            Y NC+ F  N   T +T         F ++++L +   D +           +   G RL LH   TYP I E+GI  M GT T I  +  +      P+  C+     V+ K  ++     YS +AC     Q+ + +NC C  +      L    + +K C                      D+ +  +C L     +  +  C S C     DT    TIS A+WP+++
Sbjct:  267 YGNCYIF--NWGMTEETLPSANPGTEFGLKLILDIGQEDYV--------PFLASTAGARLMLHEQRTYPFIREEGIYAMAGTETSIGVLVDKLQRKGEPYSPCTMNGSDVAIKNLYSVYNTTYSIQACLHSCFQDHMIRNCSCGHY------LYPLPEGEKYC-------------------NNRDFPDWAYCYLNLQMSVTQRETCLSMCKESCNDTQYKMTISMADWPSEA 464          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Scnn1g (sodium channel, nonvoltage-gated 1 gamma [Source:MGI Symbol;Acc:MGI:104695])

HSP 1 Score: 54.6842 bits (130), Expect = 3.072e-7
Identity = 52/246 (21.14%), Postives = 100/246 (40.65%), Query Frame = 2
Query:  800 GIVCDKAGHWVSTLNSIYINCHTF-------IVNKKFTNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQ-----TSSEINYQNKCNSPCTFFTYDTTISSAEWPTKS 1501
            G+ CD A ++    + +Y NC+TF       I++       + ++V+LY++       ++ N   + S  TG ++ +H    YP I + G  +     T I     +   +  P+ +C++  S     N     YS + C     Q ++ + C C  ++Q                  P  P +N      N+ Q  +++   +C  Q        E+  Q+ C   C+F  +  T S A+WP+++
Sbjct:  270 GMSCD-ARNFTLFHHPMYGNCYTFNNRENATILSTSMGGSEYGLQVILYINE------DEYNPFLVSS--TGAKVLVHQQNEYPFIEDVGTEIETAMSTSIGMHLTESFKLSEPYSQCTEDGSDVPVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQ------------------PLPPAANYC----NYQQHPNWM---YCYYQLYQAFVREELGCQSVCKQSCSFKEWTLTTSLAQWPSEA 481          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Asic2 (acid-sensing (proton-gated) ion channel 2 [Source:MGI Symbol;Acc:MGI:1100867])

HSP 1 Score: 50.447 bits (119), Expect = 5.511e-6
Identity = 96/424 (22.64%), Postives = 154/424 (36.32%), Query Frame = 2
Query:  305 KVFCETTSLRGVPRIAKTRDPK--RRFLW-IFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSM-------------EDLRKSSNITERKLLTMSWNINSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHW-VSTLNSIYINCHTFIVNKKFTNKTFSMEV--------VLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDTTISSAEWPTKS 1501
            ++F  T++L G+  I     P   RR LW + FV +  L  +      +  Y  Y  + +   V  +   FP+++ CNL   +      L  N L    E L  L  ++             E LR+ +N    K    S      FL+         +GHD  +M++YC           G  C   GH   +T+ + Y  C+ F  N     K     V         + LD   + Y     E +  +   GV++ +HS    P I E G  + PG  T +    ++   + PP G+C +     + F  V   YS  AC+       + +NC+C     +P D                 PF         H + A+        L    + NY   C +PC    Y+  +S  + P+K+
Sbjct:   18 QIFANTSTLHGIRHIF-VYGPLTIRRVLWAVAFVGSLGLLLVES-SERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNL---NGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPTVLEALRQKANFKHYKPKQFSM---LEFLH--------RVGHDLKDMMLYCKF--------KGQEC---GHQDFTTVFTKYGKCYMF--NSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGEC-RSSEMGLDFFPV---YSITACRIDCETRYIVENCNC-RMVHMPGD----------------APFCTPE----QHKECAE----PALGLLAEKDSNY-CLCRTPCNLTRYNKELSMVKIPSKT 382          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|Q25011|FANA_CORAP (FMRFamide-activated amiloride-sensitive sodium channel OS=Cornu aspersum OX=6535 PE=2 SV=1)

HSP 1 Score: 99.7525 bits (247), Expect = 1.663e-20
Identity = 105/538 (19.52%), Postives = 217/538 (40.33%), Query Frame = 2
Query:  323 TSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNINSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKF----TNKTFSMEVVLYLDHADE------IYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVD--FNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTAD--------YL---NKTHCNLQTSSEINYQNKCNSPCTFFTYDTTISSAEWPTKSFHTS----FLKSLRDYIQKR-MRNFYNITESTRSAWTTIIEELKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            ++  G+ +I  +RD KR+ +W   V A F A    + LL+ +Y Q+ V+   +   + P  +PS+S CN+ P+   S++T++    N+ S+ L    + ++  R   +       +   +I +++ NL    +   L H+  +M+M+C    +        +C    ++ +  +  Y NC TF   ++     T     + ++  ++  D       +Y  D N +       GVR+ +H+ G+ P  ++ GI++ PG  + +         +  P+G C+  +   I     +++Y+  AC +   Q  + + C C      +VP        +   C  +      N   S+ +H+Q+ +        YL    +   NL           C  PC+  +Y  ++S + WP + +  S    F K  R   Q   M+  Y   E         +     ++  I  + K  +++  +        +  N L + +   +  ++   +  +  L +  +  GG   +W GI+   I+
Sbjct:   50 SNAHGLAKIVTSRDTKRKVIWALLVIAGFTAATLQLSLLVRKYLQFQVVELSEIKDSMPVQYPSVSICNIEPI---SLRTIRRMYFNNESQNLITWLRFIQKFRFEQD-------SFMNSIRAFYENLGQDAK--KLSHNLEDMLMHCRFNRE--------LC-HVSNFSTFFDGNYFNCFTFNSGQRLQMHATGPENGLSLIFSVEKDDPLPGTYGVYNFDNNIL----HSAGVRVVVHAPGSMPSPVDHGIDIPPGYSSSVGLKAILHTRLPYPYGNCTNDMLNGIK----QYKYTFFACLQLCKQRLIIQRCGCKSSALPEVPS------YNATFCGVIKDWQEINRNHSNEDHNQSEEDRAFIPTPYLACEEREQKNLNNDRTYELSCGCFQPCSETSYLKSVSLSYWPLEFYQLSAVERFFKQERQAGQNHFMKTAYEYLEKLAHPSQKHLARNDSHMDDI--LSKSYSLSEKEMAKEASDLIRQNMLRLNIYLEDLSVVEYRQLPAYGLADLFADIGGTLGLWMGISVLTIM 550          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|H2QAR5|SCNNG_PANTR (Amiloride-sensitive sodium channel subunit gamma OS=Pan troglodytes OX=9598 GN=SCNN1G PE=3 SV=1)

HSP 1 Score: 75.0998 bits (183), Expect = 9.652e-13
Identity = 89/415 (21.45%), Postives = 163/415 (39.28%), Query Frame = 2
Query:  311 FCETTSLRGVPRIAKTRDPKRRFLWIFF-VTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKS-----SNITERKLLTMSWNINSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYN--SGIVCDKAGHWVSTLNSIYINCHTF-------IVNKKFTNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQ-----TSSEINYQNKCNSPCTFFTYDTTISSAEWPT 1495
            +C  T+  G  RI  +R   RR LWI F +TA  L    C +L+   Y     +     V+ +   FP+++ CN+ P    +++ L  +      E LK L    E  ++      S+I+E K    S  I     +     +  D    R   V   ++     + +  S  V     ++    + ++ NC+TF       I++       + ++V+LY++  +E Y    N   + S  TG ++ +H    YP + + G  +    +T I     +   +  P+ +C++  S     N     YS + C     Q ++ + C C  ++Q                  P  P +N      N+ Q  +++   +C  Q        E+  Q+ C   C+F  +  T S A+WP+
Sbjct:   32 YCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAVALILWQCALLVFSFY----TVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAESWSSISEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVVGFQLNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYIN--EEEY----NPFLVSS--TGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQ------------------PLPPAANYC----NYQQHPNWM---YCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPS 409          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|P51169|SCNNB_XENLA (Amiloride-sensitive sodium channel subunit beta OS=Xenopus laevis OX=8355 GN=scnn1b-a PE=1 SV=1)

HSP 1 Score: 69.707 bits (169), Expect = 5.139e-11
Identity = 81/403 (20.10%), Postives = 147/403 (36.48%), Query Frame = 2
Query:  683 INSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTN--------KTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCS---KQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEI--NYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            ++S F N+P S +  D+G    ++++ CL          G  C    ++    ++ Y NC+ F   ++  N          F +++VL ++  +         +         RL LH   ++P + + GI  MPGT T I  +  Q   ME P+  C+     +  +  + +    YS ++C R   QEE+ K C C  +     + + Y  + K   ++P                        + +L+ S  I  N  + C  PC    Y   IS A+WP+            D+I                           +  L  + +   N+T+N+          N  + + +    F+   + E  + ++   LS  GG F  W G +  CI+
Sbjct:  242 LSSIFSNVPLSGRI-DMGFKAEDLILTCLF--------GGQPCSYR-NFTHIYDADYGNCYIFNWGQEGENTMSSANPGADFGLKLVLDIEQGEY--------LPFLQTTAAARLILHQQRSFPFVKDLGIYAMPGTETSISVLVDQLEHMEAPYSSCTVNGSDIPVQNLYAEFNSSYSIQSCLRSCYQEEMVKTCKCAHYQYPLPNGSEYCTNMKHPDWVPC-----------------------YYSLRDSVAIRENCISLCQQPCNDTHYKMVISMADWPS--------AGAEDWI---------------------------FHVLSYEKDSSHNITVNR----------NGIVRLNIYFQEFNYRSISESEATNVVWLLSNLGGQFGFWMGGSVLCII 558          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|P51168|SCNNB_HUMAN (Amiloride-sensitive sodium channel subunit beta OS=Homo sapiens OX=9606 GN=SCNN1B PE=1 SV=2)

HSP 1 Score: 68.5514 bits (166), Expect = 1.072e-10
Identity = 76/350 (21.71%), Postives = 130/350 (37.14%), Query Frame = 2
Query:  851 YINCHTFIVNKKFTNKT---------FSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCS---KQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHC--NLQTSSEINYQ--NKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            Y NC+ F  N   T K          F ++++L +   D +           +   GVRL LH   +YP I ++GI  M GT T I  +  +   M  P+  C+    +V  +  ++     YS +AC R   Q+ + +NC+C  +      L    + +K C                      D+ +  HC  +LQ S          C   C    Y  TIS A+WP+++          D+I                           +  L ++ ++  N+TL++K            + + +    F+   +EE A+ ++   LS  GG F  W G +  C++
Sbjct:  269 YGNCYIF--NWGMTEKALPSANPGTEFGLKLILDIGQEDYV--------PFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHY------LYPLPRGEKYC-------------------NNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEAS--------EDWI---------------------------FHVLSQERDQSTNITLSRK----------GIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLI 538          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|Q95165|SCNNB_CANLF (Amiloride-sensitive sodium channel subunit beta OS=Canis lupus familiaris OX=9615 GN=SCNN1B PE=3 SV=2)

HSP 1 Score: 65.855 bits (159), Expect = 6.825e-10
Identity = 73/352 (20.74%), Postives = 130/352 (36.93%), Query Frame = 2
Query:  824 HWVSTLNSIYINCHTF---IVNKKF--TNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCS---KQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLN-KTHCNLQTSSEINYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            ++ S  +  Y NC+ F   +  K     N      + L LD   E Y      +   +   G RL LH   +YP I ++GI  M GT T I  +  +      P+ +C+     V  +  ++     YS +AC R   Q+ + +NC C  +      L    + ++ C                N+ +  D+    +H  +  +      N C   C    Y  TIS A+WP+++          D+I                           +  L ++ ++  N+TL++K            + + +    F+   +EE A+ ++   LS  GG F  W G +  C++
Sbjct:  261 NFTSIFHPDYGNCYIFNWGMTEKALPSANPGAEFGLKLILDIGQEDY------VPFLTSTAGARLMLHEQRSYPFIKDEGIYAMSGTETSIGVLVDRLERKGEPYSQCTVNGSDVPVRNLYSDYNTTYSIQACIRSCFQDHMIQNCSCAHY------LYPLPRGERYC----------------NNREFPDWAYCYSHLRMSVAQRETCINMCKESCNDTQYKMTISMADWPSEAS--------EDWI---------------------------FHVLSQERDQSTNITLSRK----------GVVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLI 539          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A094ZK54 (FMRFamide-activated amiloride-sensitive sodium channel OS=Schistosoma haematobium OX=6185 GN=MS3_03260 PE=3 SV=1)

HSP 1 Score: 436.032 bits (1120), Expect = 8.717e-141
Identity = 224/540 (41.48%), Postives = 330/540 (61.11%), Query Frame = 2
Query:  284 SAISKHWKVFCETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNINSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKTFSMEVVLYLDH-ADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQY--LPAT-----PFSNATLSSFNHSQTADYLNKTHCNLQTSSEIN-YQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEE--------LKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            + I + ++ FCETTSLRGVPRI  T+D KRRFLW+ FV +FF+ CITC+  +I QY ++DVIHQPK +Y++P PFPS++ CNLRP S+  I+ LK  G+  V  Y + LK+ M     S  +  R+ LTM W+ ++Y  NLP+    N+LGH   ++V  C ++YK G    G  C+K+G+W  T + ++ NC+T+ +N   TN   +ME+V+YLD+  ++  C DC E  + SQLTG RL LH   +YP + E+G+NLMPGT+T+I+F   +W+MMEPPHG+CSK   + ISFN V + +SEEAC   ++QE++A NC C+    +P   +   +  + CQ   LPAT      F+ +    FN    + Y     C  +T + ++ YQ  C   C  +TY  +I++A+WPTK+F T F+     +I++   + Y+  +ST +   TI  E        L+PY  +I  + K+ ++    K+L + +    NFLSI + R NFD+  VEEKA VSLT+  SQ GG+ SIW G+TF CIV
Sbjct:  125 TQIKRQFRQFCETTSLRGVPRIVSTKDSKRRFLWLIFVISFFIGCITCLTFIISQYLEFDVIHQPKKLYDQPRPFPSVTLCNLRPFSTRDIRKLKKAGVLPVDMYFEMLKRFM----TSVPMEYRRYLTMLWDFSTYLANLPDLVDANNLGHTLEDIVKRCFILYKTGSVTRGTACEKSGYWTKTQDRVFHNCYTYTINPNKTNTALNMELVVYLDNLIEQTDCFDCQERVMASQLTGARLLLHPGASYPRVAEEGVNLMPGTMTDIRFTVYEWSMMEPPHGRCSKNTPQFISFNNVNYTFSEEACHAHMVQEKVASNCQCLT-QHLPIPTHLLGKDLRKCQAFKLPATYQMLDNFNESKQLYFNDEAVSTYARFAECAEKTGTAMDSYQIGCRPACVRYTYKPSITAAQWPTKTFLTWFVTK---FIKEMEASGYSRLKSTNNETLTIFNERMEEIRTPLQPY-EIISNLTKQGHLQEAIKMLMNTQIFEQNFLSIIISRPNFDLERVEEKAVVSLTSLFSQIGGLLSIWIGLTFVCIV 655          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A4Z2DTC2 (FMRFamide-activated amiloride-sensitive sodium channel OS=Schistosoma japonicum OX=6182 GN=EWB00_006004 PE=3 SV=1)

HSP 1 Score: 432.18 bits (1110), Expect = 2.693e-139
Identity = 224/537 (41.71%), Postives = 329/537 (61.27%), Query Frame = 2
Query:  284 SAISKHWKVFCETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNINSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKTFSMEVVLYLDH-ADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQY--LPAT--PFSNATLSS---FNHSQTADYLNKTHCNLQTSSEIN-YQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITES-TRSAWTTIIEE----LKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            + I + ++ FCETTSLRGVPRI  T+D KRRFLW+ FV AFF+ CI C+  +I QY ++DVIHQPK +Y++P PFPS++ CNLRP S+  I+ LK  G+  V  Y + LK+ M ++     +  R+ LTM W+ ++Y  NLP+    ++LGH   ++V  C ++YK G    G  C+K+G+W  T + ++ NC+T+ +N   TN   +ME+VLYLD+  ++  C DC E  + SQLTG RL LH   +YP + E+G+NLMPGT+T+I+F   +W+MMEPPHG+C+K   + ISFN V + +SEEAC   ++QE++A NC C+    +P   +   ++ + CQ   LPAT    +N   S    FN    ++Y     C  +T + I+ YQ  C   C  +TY  +I++A+WPTK+F T F+      ++    +  N+T + T + +   +EE    L+PY  LI  + KE  +    K+L   +    NFLSI + R NFD+  VEEKA VSLT+  SQ GG+ SIW G+TF CIV
Sbjct:  125 TQIKRQFRQFCETTSLRGVPRIVSTKDSKRRFLWLIFVIAFFIGCIICLTFIISQYLEFDVIHQPKKLYDQPRPFPSVTLCNLRPFSTRDIRKLKKAGVLPVDMYFEMLKRFMVNVP----LEYRRYLTMLWDFSTYLANLPDLVDESNLGHTLEDIVKRCFILYKTGSVTRGTACEKSGYWTKTQDRVFHNCYTYTINPNRTNTALNMELVLYLDNLIEQTDCFDCQERVMASQLTGARLLLHPGASYPRVAEEGVNLMPGTMTDIRFTVYEWSMMEPPHGRCNKHTPEFISFNNVNYTFSEEACHAHMVQEKVASNCQCLT-QHLPIPTHLLGKNLRKCQAFKLPATYQMLNNLNESKQLYFNEEAVSNYSQFAECAEKTGTAIDTYQIGCRPACVRYTYKPSITAAQWPTKTFLTWFVNKFIKEMETSGYSRINLTNNETLTIFNERMEEIRAPLQPY-ELIANLTKEGRLQEAIKMLMQTQIFEQNFLSIIISRPNFDLERVEEKAVVSLTSLFSQIGGLLSIWIGLTFVCIV 655          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A3Q0KJ87 (Putative amiloride-sensitive sodium channel OS=Schistosoma mansoni OX=6183 PE=3 SV=1)

HSP 1 Score: 431.409 bits (1108), Expect = 2.984e-139
Identity = 223/540 (41.30%), Postives = 328/540 (60.74%), Query Frame = 2
Query:  284 SAISKHWKVFCETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNINSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKTFSMEVVLYLDH-ADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQY--LPAT-----PFSNATLSSFNHSQTADYLNKTHCNLQTSSEIN-YQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEE--------LKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            + I + ++ FCETTSLRGVPRI  T+D KRRFLW+ FV +FF+ CITC+  +I QY ++DVIHQPK +Y++P PFPS++ CNLRP S+  I+ LK   +  V  Y + LK+ M     S  +  R+ LTM W+ ++Y  NLP+    N+LGH   ++V  C ++YK G    G  C+K+G+W  T + ++ NC+T+ +N   TN   +ME+V+YLD+  ++  C DC E  + SQLTG RL LH   +YP + E+G+NLMPGT+T+I+F   +W+MMEPPHG+CSK   + ISFN V + +SEEAC   ++QE++A NC C+    +P   +   +  + CQ   LPAT      F+ +    FN+   + Y     C  +T + ++ YQ  C   C  +TY  +I++A+WPTK+F T F+     +I++   + Y+  +ST +   +I  E        L+PY  +I  + KE  +    K+L   +    NFLSI + R NFD+  VEEKA VSLT+  SQ GG+ SIW G+TF CIV
Sbjct:  106 TQIKRQFRQFCETTSLRGVPRIVSTKDSKRRFLWLIFVISFFIGCITCLTFIINQYLEFDVIHQPKKLYDQPRPFPSVTLCNLRPFSTRDIRKLKKAEVLPVDMYFEMLKRFM----ISVPVEYRRYLTMLWDFSTYLANLPDLVDANNLGHTLEDIVKRCFILYKTGSVTRGTACEKSGYWTKTQDRVFHNCYTYTINPNKTNTALNMELVVYLDNLIEQTDCFDCQERVMASQLTGARLLLHPGASYPRVAEEGVNLMPGTMTDIRFTVYEWSMMEPPHGRCSKNTPQFISFNNVNYTFSEEACHAHMVQEKVASNCQCLT-QHLPIPTHLLGKDLRKCQAFKLPATYQMLDNFNESKQLYFNNEAVSTYARFAECAEKTGTAMDSYQIGCRPACVRYTYKPSITAAQWPTKTFLTWFVTK---FIKEMELSGYSRLKSTNNETLSIFNERMEEIRKPLQPY-EIIANLTKEGRLQEAIKMLMQTQIFEQNFLSIIISRPNFDLERVEEKAVVSLTSLFSQIGGLLSIWIGLTFVCIV 636          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: G4V8Q7 (Putative amiloride-sensitive sodium channel OS=Schistosoma mansoni OX=6183 GN=Smp_093210 PE=3 SV=1)

HSP 1 Score: 427.172 bits (1097), Expect = 8.031e-138
Identity = 222/540 (41.11%), Postives = 322/540 (59.63%), Query Frame = 2
Query:  284 SAISKHWKVFCETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNINSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKTFSMEVVLYLDH-ADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQY--LPAT-----PFSNATLSSFNHSQTADYLNKTHCNLQTSSEIN-YQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEE--------LKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            + I + ++ FCETTSLRGVPRI  T+D KRRFLW+ FV +FF+ CITC+  +I QY ++DVIHQPK +Y++P PFPS++ CNLRP S+  I+ LK   +  V  Y + LK+ M     S  +  R+ LTM W+ ++Y  NLP+    N+LGH   ++V  C ++YK G    G  C+K+G+W  T + ++ NC+T+ +N   TN   +ME+V+YLD+  ++  C DC E  + SQLTG RL LH   +YP + E+G+NLMPGT+T+I+F   +W+MMEPPHG+CSK   + ISFN V + +SEEAC   ++QE++A NC C+    +P   +   +  + CQ   LPAT      F+ +    FN+   + Y     C  +T + ++ YQ  C   C  +TY  +I++A+WPTK+F T F                 +T+ST +   +I  E        L+PY  +I  + KE  +    K+L   +    NFLSI + R NFD+  VEEKA VSLT+  SQ GG+ SIW G+TF CIV
Sbjct:  106 TQIKRQFRQFCETTSLRGVPRIVSTKDSKRRFLWLIFVISFFIGCITCLTFIINQYLEFDVIHQPKKLYDQPRPFPSVTLCNLRPFSTRDIRKLKKAEVLPVDMYFEMLKRFM----ISVPVEYRRYLTMLWDFSTYLANLPDLVDANNLGHTLEDIVKRCFILYKTGSVTRGTACEKSGYWTKTQDRVFHNCYTYTINPNKTNTALNMELVVYLDNLIEQTDCFDCQERVMASQLTGARLLLHPGASYPRVAEEGVNLMPGTMTDIRFTVYEWSMMEPPHGRCSKNTPQFISFNNVNYTFSEEACHAHMVQEKVASNCQCLT-QHLPIPTHLLGKDLRKCQAFKLPATYQMLDNFNESKQLYFNNEAVSTYARFAECAEKTGTAMDSYQIGCRPACVRYTYKPSITAAQWPTKTFLTWF-----------------VTKSTNNETLSIFNERMEEIRKPLQPY-EIIANLTKEGRLQEAIKMLMQTQIFEQNFLSIIISRPNFDLERVEEKAVVSLTSLFSQIGGLLSIWIGLTFVCIV 622          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: G7YD97 (FMRFamide-activated amiloride-sensitive sodium channel OS=Clonorchis sinensis OX=79923 GN=CLF_105251 PE=3 SV=1)

HSP 1 Score: 411.764 bits (1057), Expect = 6.257e-132
Identity = 213/534 (39.89%), Postives = 320/534 (59.93%), Query Frame = 2
Query:  290 ISKHWKVFCETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNINSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKTFSMEVVLYLDH-ADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFN-QVPDDLNNYLQHKKICQYLPAT-----PFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQ-NKCNSPCTFFTYDTTISSAEWPTKSFHTSFL-KSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIEKI----EKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            I   +K FCETTSLRGVPRI  T+D KRR LW+ FV AFF+ CITC++ LI QY  YDVIHQPK +Y+ P  FPS++ CNLRP S+  I+ LK  G+  V  Y   +++ +  +R  +    R+ +TM W +++Y  NLP +   + LGH + ++V  C ++YK+G  N G  C+ +G+W  T + ++ NC+T+ + +  TN+  +ME+V+YLD+  ++  C DC E    SQLTG RL LH   +YP + E+GINLMPGT+T+I+F   +W+MMEPPHG+CS      I+FN V + YSEEAC + V Q ++ + C+C+  +  +P +L +   ++      PAT      F+    S FN    A  +  + C  +  ++++     C   C  +TY  +I++A+WPTK+F T F+ K L+      +R   ++TE+ +      ++EL+  LS  E+I       +     +KL++   F   NFL+I + R NFD+  VEEKA VSLT+  SQ GG+ SIW G+TF CIV
Sbjct:   81 IRGQFKQFCETTSLRGVPRIVSTKDTKRRLLWLIFVLAFFVGCITCLIFLINQYLAYDVIHQPKKLYDLPRSFPSVTICNLRPFSTKDIRKLKAAGVVPVDMYFDNIQRMIPQVRPEN----RRYMTMLWTMSAYLYNLPETLDESALGHSKHDIVKRCYIVYKRGTMNRGTDCESSGYWTKTRDPVFHNCYTYTIFQNLTNQVLNMEMVVYLDNLVEQTDCFDCQERVRASQLTGARLLLHPRASYPRVAEEGINLMPGTMTDIRFSVYEWSMMEPPHGRCSTSTPVSINFNHVNYSYSEEACHKHVRQLKVVQTCNCLTQSLPIPTELLDRKLNRCEAFRFPATIDLSDNFNMTKQSYFNDESIARLVQSSRCAEEILTKLDSSATGCRPACVRYTYRPSITAAQWPTKTFLTWFVTKFLKRITTATIRGRPHMTEAEQVRVQESLDELQELLSPYEEILNLTRAGKQAEAIQKLMSTEIF-ERNFLAIVISRPNFDVERVEEKAVVSLTSLFSQIGGLLSIWVGLTFVCIV 609          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Cavefish
Match: asic1a (acid-sensing ion channel 1A-like [Source:NCBI gene;Acc:103034215])

HSP 1 Score: 51.2174 bits (121), Expect = 2.362e-6
Identity = 76/327 (23.24%), Postives = 126/327 (38.53%), Query Frame = 2
Query:  305 KVFCETTSLRGVPRI-AKTRDPKRRFLWIFFV--TAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNIN-SYFLNLPNSTQP--NDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTF--------IVNKKFTNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDC 1243
            +VF   ++L G+  I    R   R  LW+ F   +  FL C+   V  ++ Y +Y  + +   V      FP+++ CNL   ++     +  N L    E L  L    E +R    I E  L ++    +   F   P +     N  GHD  +M++ C           G  C      V  + + Y  C+TF        +++ K    +  +E++L  D   + Y     E    S   G+++ +HS    P I + G  + PG  T +    ++   + PP G C         F      YS  AC+       L +NC+C
Sbjct:   23 QVFAHMSTLHGIAHIFTYDRITLRCCLWLLFFLSSVAFLVCVC--VDRVLFYLEYPHVTKVDEVVAPAMVFPAVTLCNL---NAFRFGRVTRNDLYHAGELLALLNSRYE-IRDVHLIEESVLESLKTKADFQNFKPRPFNMMEFYNRTGHDIRDMLLSCQF--------RGSPCRPEDFKV--VFTRYGKCYTFNSGETGPLLISMKGGMGS-GLEIML--DIQQDEYLPVWGETDETSFEAGIKVQVHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLVYLPPPWGNCKTGTLDSDFFTA----YSISACRIDCETRYLVENCNC 326          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Sea Lamprey
Match: SCNN1G (sodium channel epithelial 1 gamma subunit [Source:HGNC Symbol;Acc:HGNC:10602])

HSP 1 Score: 57.3806 bits (137), Expect = 8.356e-9
Identity = 55/271 (20.30%), Postives = 106/271 (39.11%), Query Frame = 2
Query:  725 NDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKTFSMEVVLYLDHADEIYCN--DCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQ-VPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSL 1528
            + LG+   E ++ CL         SG VCD +  +    + I  NC TF  N     K+  +     +D+   +  N    N +   +   G ++ +H   T P I   GI++ P   + +         +  P+  C+   S     +  +  YS + C+    Q E+ K+C C ++ Q +P       +  + C Y              +++   +Y      ++    E+     C   C+   ++ T+S A+WP+K+     L++L
Sbjct:  240 DKLGYSADEFIIDCLF--------SGTVCDPSTSFKKLQHPILGNCFTF--NDGSDGKSLDIASA-GIDYGLHMVLNTRQDNSLPYLAMGAGAKIGIHLQNTTPFIEAVGIDIPPAMESSLGLRVNDVQKLGDPYSDCTMDGSDIDVKSLYDSPYSVQTCQNSCFQWEMIKSCGCANYEQPLP-------EGSRFCNY--------------DNNPGWEYCYYRLYDMYIKEELKCIQVCRQICSETEHEVTLSLADWPSKASKGWLLRAL 478          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Sea Lamprey
Match: SCNN1A (sodium channel epithelial 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:10599])

HSP 1 Score: 54.6842 bits (130), Expect = 5.332e-8
Identity = 48/224 (21.43%), Postives = 82/224 (36.61%), Query Frame = 2
Query:  851 YINCHTF-------IVNKKFTNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDTTISSAEWPTKS 1501
            Y NC+TF       +       + + + ++L  +  D I           S + G R+ +H   + P + E G ++ PG  T +     +   M  P+G C++  S     N     Y+ +  +    Q  L + C C  +                  + P  P  NA+  S+N++  A +          S E+   +KC  PCT   +  T   A WP  S
Sbjct:  238 YGNCYTFNSANSSKLWQASKPGRDYGLSLILRTEQNDYI--------PFLSTVAGARIMVHDQESPPFMEEGGFDMRPGFETSLGIRMLEATRMPDPYGNCTEDGSNVPVLNLYSSAYTVQVPECSCFQLALVEACGCGYY------------------FYPLPP--NASYCSYNNTAWAGHCYYKLYRQFISDELGCVDKCAQPCTTKRFAVTPGYAAWPDSS 433          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO42137 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2F2])

HSP 1 Score: 83.1889 bits (204), Expect = 1.040e-16
Identity = 110/545 (20.18%), Postives = 203/545 (37.25%), Query Frame = 2
Query:  311 FCETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSI----------------KTLKNNGLNSVSEYLKQLKQSMEDLRK-------SSNITERKLLTMSWNINSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAG------HWVSTLNSIYINCHTFIVNKKFTNKTFSMEVVLYLDHADEIYCN---DCNE-MKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKC---SKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGIT 1837
            F + T+  G  R+  T   K R  W+ F  A +   +  +V L+ QY    +  + +  + +   FP ++ CN+  L +  +                KT   N  NS + ++     S E+ +K       +++   R+L++ +                    H   ++++ C          +G+ C  +       +W  T N  + NC+ F   K    +   +        ++ +      + NE ++  +++ G+++ +   G  P   ++GI +MPG  T I+    Q   ++P   +    S ++S K  F      YS  ACK   L     + C C ++N  P+     +Q + I       P  N       +S   D LNK +   +  S      +C   C+  ++D T+SSA WP +SF                       E T+ A+   +  L    S           + +K  +N     S N   + V     D +LV+E  + +  + LS  GG   +W GI+
Sbjct:   18 FLQETTAHGFGRLGATAGSKWRLYWVMFCLAAYCVFVWQLVGLVNQYNSKPIKTRTQLKHAQKLDFPVVTICNMNVLRASRLPPKLRTKFDQIINNTNKTSPRNSSNSRNAFVDPQDLSFEETKKFEILHAVTAHDDYRELVSAA--------------------HQLEDILLSCNF--------NGVNCRNSKDPTIPTYWTQTWNDNFGNCYMFNSVKTHNGEKVDLYSSSVPGESNGLTLQLNLEQNEYLEGITEVAGMKVTISDQGVLPFPGQQGIRIMPGQSTGIQMTKLQTRRIDPFKNRSCESSNEMSDKNLFFGYNMTYSIMACKYSCLNARKIERCGCTNYN-TPE-----MQKRNI-------PLCNRL-----NSTIIDCLNKAYDTFEDGS---CDRECPPSCSEVSFDLTVSSARWPARSF-----------------------EVTKYAYFLRVRVLNKIAS-----------SSSKYFVN-----SENIAQVHVYYGELDYLLVQETLAYTFMSLLSDIGGQMGMWIGIS 474          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO37452 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFR0])

HSP 1 Score: 51.6026 bits (122), Expect = 1.084e-6
Identity = 71/301 (23.59%), Postives = 117/301 (38.87%), Query Frame = 2
Query:  698 LNLPNSTQPNDL----GHDRLEMVMYCLLIYKQGIYNSGIVCDKAGH--WVSTLNSIYINCHTFIVNKKF---------TNKTF-SMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMM--EPPHGKC---SKQVSKKISFNK-VEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRD 1534
            L L  +T+P D+    GH   +MV+ C   Y+      GI C       W    +  Y NC+ F   K +         +NK   +  + L L+     Y          S   G+R+ + + G  P  +EKGI++ PG  T      R  N++  +P + K    S  +  +  + K     YS   C    L  +    C C+++ + P+     + ++ +C  L         +   N  Q+    NK  C+          +KC  PC    +  +ISSA WPT  +   FL  L++
Sbjct:  269 LVLSLATKPEDMLMEAGHQFYDMVLSC--TYR------GIPCTNYTENLWSRFWHYRYGNCYVFNSGKDWQGEPKPILRSNKPGPASGLTLELNAEQHEYVGQ------LSHEAGMRVLISTQGEMPSPLEKGISVSPGFSTTTGI--RMTNILRADPFNNKSCLSSDDIDPENLYKKRYNVSYSRTTCMDSCLAHKQLDMCGCLEY-RFPN-----IDNRTVCDILDID-----VIRCLNKVQSLYQDNKLGCS----------DKCRPPCNEEVFKLSISSARWPTDDYEAHFLDELKE 532          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Match: ENSORLT00000008662.2 (acid sensing ion channel subunit 1 [Source:NCBI gene;Acc:101155423])

HSP 1 Score: 60.8474 bits (146), Expect = 2.941e-9
Identity = 80/343 (23.32%), Postives = 128/343 (37.32%), Query Frame = 2
Query:  284 SAISKHWKVFCETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKT---------LKNNGLN-SVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNIN-SYFLNLPNSTQP------NDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKTFSME------VVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDC 1243
             ++++  K+F + T+  G+  I       RR  W+    A            +       V  +   VY K   FP+++ CN   L    +K          L   G N  +S   K+   S+ D    S   E     +S  ++ ++FL  P  +QP      N LGH   EM++YC           G +C       ST+ + Y  C+TF   K       +M+      + L LD   + Y     E    S   G+++ +H+    P I + G  + PG  T +    ++   + PP G C         FN     YS  AC+       L +NC+C
Sbjct:   12 GSVTEAGKLFLKHTTFHGLRHIFLGGSYPRRVAWLLAFLAALALLFIWSTNRVRYLLSSPVYTKAHMVYAKRLVFPAVTICNQNLLLPRRMKKTDIFSAGRWLGLLGRNWQLSPTAKEALMSLRDESSESATGEPPWYPLSRILDFNHFLPPPRDSQPSMKQLLNRLGHQLEEMLLYCRY--------QGELCGPRN--FSTIFTRYGKCYTFNSGKDGQPLMVTMKGGTGNGLELMLDIQQDEYLPVWGETDETSFEAGIKVQIHTQEEPPFIDQLGFGVAPGFQTFVSCQEQRLTYLPPPWGDCKSTPMDSDFFN----SYSITACRIDCETRYLVENCNC 340          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Match: ENSORLT00000031246.1 (acid sensing ion channel subunit 1 [Source:NCBI gene;Acc:101155423])

HSP 1 Score: 56.6102 bits (135), Expect = 5.187e-8
Identity = 76/323 (23.53%), Postives = 122/323 (37.77%), Query Frame = 2
Query:  305 KVFCETTSLRGVPRI-AKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITER--KLLTMSWNINSYFLNLPNSTQPND-LGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKTFSME------VVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDC 1243
            +VF   ++L G+  +    R   +R LWI F        +   V  +  Y +Y  + +   V      FP+++FCNL   +S     +  N L    E L  L    E +R    + E   ++L    +  SY     N  +  D  GHD  +M++ C           G  C      V  + + Y  C+TF   K       +M+      + L LD   + Y     E    S   G+++ +H+    P I + G  + PG  T +    ++   + PP G C         FN     YS  AC+       L +NC+C
Sbjct:   19 EVFATRSTLHGISHMFTYERMCLKRTLWILFFMLSVGVLVMVCVDRVQFYFEYPHVTKLDEVAASMIVFPAITFCNL---NSFRFSRVTRNDLYHAGELLALLNGRYE-IRDPHLVEENVLQVLRERADFESYKPRSFNMREFYDRTGHDIKDMLLSCSY--------RGTECSAENFKV--IFTRYGKCYTFNSGKDGQPLMVTMKGGTGNGLELMLDIQQDEYLPVWGETDETSFEAGIKVQIHTQEEPPFIDQLGFGVAPGFQTFVSCQEQRLTYLPPPWGDCKSTPMDSDFFN----SYSITACRIDCETRYLVENCNC 323          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Match: asic1a (acid-sensing ion channel 1 [Source:NCBI gene;Acc:101159102])

HSP 1 Score: 55.4546 bits (132), Expect = 1.204e-7
Identity = 90/415 (21.69%), Postives = 154/415 (37.11%), Query Frame = 2
Query:  305 KVFCETTSLRGVPRI-AKTRDPKRRFLWIF-FVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNINSYFLNLPNSTQPNDL-------GHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKF------TNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPA-TPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDTTISSAEWPTKS 1501
            +VF  +++L G+  I    R   +R LW+  F+ +  L    C V  I  Y +Y  + +   V      FP+++FCNL   ++     +  N L    E L  L    E   +  ++ E  +L  S  + + F N     +P ++       GHD  +M++ C        +  G  C + G +   + + Y  C+TF            T       + L LD   + Y     +    S   GV++ +HS    P I + G  + PG  T +    ++   + PP G C         F+     YS  AC+       L  NC+C                     Y+P   P+ +  L         D+L      +Q  ++      C +PC    Y+  +S  + P+K+
Sbjct:   19 EVFAHSSTLHGIAHIFTYERLCIKRCLWLLVFLCSLTLLLYVC-VDRIHYYLEYPHVTRLDEVATPIMTFPAITFCNL---NAFRFSRVTRNDLYHAGELLALLNHRYE--IRDVHLVEESVLE-SLKVKADFHNF--KPRPFNMREFYDRTGHDIKDMLLSC--------HFHGTEC-RPGDF-KVVFTRYGKCYTFNAGGDGRPPLITTKGGMGNGLELMLDIQQDEYLPVWGDTDETSFEAGVKVQIHSQDEPPSIDQLGFGVAPGFQTFVSCQEQRLIYLPPPWGDCKVTPMDSDFFD----SYSITACRVDCETRYLVDNCNCR------------------MVYMPGDAPYCSPELYKECADPALDFL------VQRDNDFCV---CETPCNMTRYNKELSFVKIPSKA 383          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Match: ENSORLT00000021925.2 (acid-sensing ion channel 1C [Source:NCBI gene;Acc:101174951])

HSP 1 Score: 54.6842 bits (130), Expect = 2.332e-7
Identity = 75/333 (22.52%), Postives = 126/333 (37.84%), Query Frame = 2
Query:  284 SAISKHWKVFCETTSLRGVPRI-AKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTM---SWNINSYFLNLPNSTQ-PNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTF--------IVNKKFTNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDC 1243
            SA   + + F   ++L G+  I A      RRFLW           +   +  ++ Y +Y  + +   V      FP+++FCNL   +      +  N L  V E L  L    +    + ++ E ++L       N N++   L N T   N  GHD  EM++ C    +          D      +T+ + Y  C+TF        ++          +E++L  D   + Y     E    S   G+++ +HS    P I + G  + PG  T +    +    + PP G C         F+     YS  AC+       L +NC+C
Sbjct:   11 SARPSNLQAFANISTLHGMSHIFAYGHMTFRRFLWTLSFLGSLSLLMLVCMDRVVYYLEYPHVTKLDEVAATNLTFPAVTFCNL---NEFRFSKITRNDLYHVGELLALLNNDHQ--IANPHLAEPEVLAALKDKANFNNFKPKLFNMTDFYNRTGHDISEMLLQCTFRGE----------DCYAMNFTTIYTRYGKCYTFNSGLDGNPLLTTLKGGTGNGLEIML--DIQQDEYLPVWGETDETSYEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQQQLLQYLPPPWGDCKSTPIDSEFFST----YSITACRIDCETRYLLENCNC 322          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000081650.1 (SMESG000081650.1)

HSP 1 Score: 1188.71 bits (3074), Expect = 0.000e+0
Identity = 602/602 (100.00%), Postives = 602/602 (100.00%), Query Frame = 2
Query:  119 MNNELEDKTVYNSLKDSNCEKYRSSQVYPPVFHLQXXXXXXXXXXXRKDSRCLGWSAISKHWKVFCETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNINSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIVXXXXXXXXXXXXXXSKKHYQNIRK 1924
            MNNELEDKTVYNSLKDSNCEKYRSSQVYPPVFHLQSSSSINNKYSSRKDSRCLGWSAISKHWKVFCETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNINSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIVEILELFILIFEEIFSKKHYQNIRK
Sbjct:    1 MNNELEDKTVYNSLKDSNCEKYRSSQVYPPVFHLQSSSSINNKYSSRKDSRCLGWSAISKHWKVFCETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNINSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIVEILELFILIFEEIFSKKHYQNIRK 602          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000072389.1 (SMESG000072389.1)

HSP 1 Score: 572.392 bits (1474), Expect = 0.000e+0
Identity = 275/530 (51.89%), Postives = 379/530 (71.51%), Query Frame = 2
Query:  287 AISKHWKVFCETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNINSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEI-NYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELK-------PYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
             I  H   FCETTSLRGVPRI K+ +PK+R LW FFV  FF+AC+TC+ LL+ QYR YDVIHQP+TVYN+  PFPSL+ CNLRPL+S  I+ L  N + +  E++++LK  +   +K     + KL+T SWN+N+YFLNLP S  PNDLGH R  MV+ C ++Y++GIY+SG  C+K G WVST++ IY NCHTFIVN+ +TN+TFS+E+VLYLD+ ++I C DC  ++I +QLTG  LNLHS GTYP+I  +G+NL+PGTLTEI+F PR+W+MMEPPHGKCSK +   +SF+  +F+YSE +CK+K+LQ+EL K C+C+D+ QVP +L    +  KIC++L      N T  + +      + N+T C  +T+S   N  ++C SPCT+FTYDT+ISSA+WP KS+HT F+K    YI+++M+  +     ++S+   +IE LK       PY  +++  E+++ +  N +LL +L F+  N L++QV R NFDI LVEEKA VSLT+FLSQTGG+ SIWSGITFFC+V
Sbjct:   58 VIKSHCIKFCETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQSKLVTTSWNLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCKQKLLQQELIKQCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVK----YIEEKMKRMHTDLPVSKSS-DNVIEPLKDLYKKLLPYKRVMKLKEEKKLIKAN-ELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVV 581          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000013147.1 (SMESG000013147.1)

HSP 1 Score: 417.157 bits (1071), Expect = 4.922e-137
Identity = 206/524 (39.31%), Postives = 329/524 (62.79%), Query Frame = 2
Query:  299 HWKVFCETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSS---NIT--ERKLLTMSWNINSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSE-INYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            H+K FCETTSLRGVP+I  ++  + R LW+ FV  FF+AC+TC +LLI QY  YDVIHQPKT YN P+ FPS++FCNLRP SS +++ LK + + S+ ++L    +S+  +  SS   N+T  +++LLT +  +  + +NLP S     +GH +  M++ C + Y  G   S   C+  G W+ T N +++NC+T+ +++K+     +++++L++D   E  C DCN+    SQ+TG+R +LH++ TYP++I +G NL PGT T+  F  +QWNMM+PP+GKCSK + +K +F + +F YS + C++  +Q  L  NC C+ +  +P    +  + + IC +   + F N +    + +    +LN+T C    S   +N  + C +PC ++T+D  +SS  +PTKSFH  F K+++  + +++RN   I +   +   +I+ + K Y  +  KI K  ++   +KLL +   +  NFL+IQ+ R +F II VEEK  +S+T+FLSQTGG+FSIWSGITFFC+V
Sbjct:  147 HFKKFCETTSLRGVPKIVHSQKKQFRMLWVIFVLVFFIACMTCTILLIKQYLAYDVIHQPKTSYNDPSNFPSVTFCNLRPFSSRTVELLKRSNIKSLVDFLHGFGRSV--VMNSSIMLNLTSEDKQLLTSTLFLELFLMNLPLSISKESIGHSQNSMIIDCSIQYANGSEISSTKCELGGKWILTKNELFLNCYTYTMDEKYLQTATAVDLILHVDDRLEFECPDCNQFFTASQMTGIRFSLHTAHTYPDVILEGQNLSPGTFTDAVFYTKQWNMMQPPYGKCSKTLVEKYAFEEGDFLYSLKGCQKYTIQNLLYDNCGCIKYTNIPKRFAHLNKSQDICNFFEYSVFKNVSKYKLDLNNVKFFLNRTKCKKIISHRFLNDFSTCTNPCQYYTFDVKVSSGIYPTKSFHLYFTKNIQKILIRKIRNSSKIED--MNELKSILHKFKIYDEISRKI-KNGSIAEAEKLLKNTDVIEKNFLTIQINRQDFSIIKVEEKEVISITSFLSQTGGMFSIWSGITFFCLV 665          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000013147.1 (SMESG000013147.1)

HSP 1 Score: 417.157 bits (1071), Expect = 5.133e-137
Identity = 206/524 (39.31%), Postives = 329/524 (62.79%), Query Frame = 2
Query:  299 HWKVFCETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSS---NIT--ERKLLTMSWNINSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSE-INYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            H+K FCETTSLRGVP+I  ++  + R LW+ FV  FF+AC+TC +LLI QY  YDVIHQPKT YN P+ FPS++FCNLRP SS +++ LK + + S+ ++L    +S+  +  SS   N+T  +++LLT +  +  + +NLP S     +GH +  M++ C + Y  G   S   C+  G W+ T N +++NC+T+ +++K+     +++++L++D   E  C DCN+    SQ+TG+R +LH++ TYP++I +G NL PGT T+  F  +QWNMM+PP+GKCSK + +K +F + +F YS + C++  +Q  L  NC C+ +  +P    +  + + IC +   + F N +    + +    +LN+T C    S   +N  + C +PC ++T+D  +SS  +PTKSFH  F K+++  + +++RN   I +   +   +I+ + K Y  +  KI K  ++   +KLL +   +  NFL+IQ+ R +F II VEEK  +S+T+FLSQTGG+FSIWSGITFFC+V
Sbjct:  144 HFKKFCETTSLRGVPKIVHSQKKQFRMLWVIFVLVFFIACMTCTILLIKQYLAYDVIHQPKTSYNDPSNFPSVTFCNLRPFSSRTVELLKRSNIKSLVDFLHGFGRSV--VMNSSIMLNLTSEDKQLLTSTLFLELFLMNLPLSISKESIGHSQNSMIIDCSIQYANGSEISSTKCELGGKWILTKNELFLNCYTYTMDEKYLQTATAVDLILHVDDRLEFECPDCNQFFTASQMTGIRFSLHTAHTYPDVILEGQNLSPGTFTDAVFYTKQWNMMQPPYGKCSKTLVEKYAFEEGDFLYSLKGCQKYTIQNLLYDNCGCIKYTNIPKRFAHLNKSQDICNFFEYSVFKNVSKYKLDLNNVKFFLNRTKCKKIISHRFLNDFSTCTNPCQYYTFDVKVSSGIYPTKSFHLYFTKNIQKILIRKIRNSSKIED--MNELKSILHKFKIYDEISRKI-KNGSIAEAEKLLKNTDVIEKNFLTIQINRQDFSIIKVEEKEVISITSFLSQTGGMFSIWSGITFFCLV 662          
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000064187.1 (SMESG000064187.1)

HSP 1 Score: 270.396 bits (690), Expect = 8.602e-82
Identity = 169/534 (31.65%), Postives = 277/534 (51.87%), Query Frame = 2
Query:  308 VFCETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQ-SMEDLRKSSNITERKLLTMSWNINSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKA---GHWVSTLNSIYINCHTFIVNKKFTNKTFSMEVVLYLD-HADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDC--VDFNQVPDDLNNYLQHKKICQYLPA-TPFSNA-TLSSFNHS---QTADYLNKTHCNLQTSSEINYQNK-----CNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSLIE--KIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIV 1852
            +FC++TS+RG+P I + R+   R +W+FFV+A  +    C++ L+ QY +++VIH P+ + +  +PFPS++ CNLRP+S    + L+ N   +   Y +      ++ L K +   +    T + N  +Y  +LP++ +   LG++    V+ C + + +G   S + C      G W   +++ Y+NCHTF ++    N   ++E+ LYLD + +   C DC   +I SQL+G  + +H+ GT+P I  + IN+ PG+LTEI           PP+G+CS +  K +        YSE AC++  +Q E+ K C C  +++  V  D+         C  +P   P  N  T ++ N S   Q    LN+  C +   S IN  NK     C+ PC+F +Y+T  S + WPTK +   +L S       R+   + +   T         E +PY  +IE  K+ KE+       LL     +  N L++ + R NF++  VEEK  +SLT+FLSQ+GG+FSIW G+T   +V
Sbjct:   47 LFCQSTSIRGIPHIFRARNKTVRVMWLFFVSALIIGWCICMIFLLRQYLEFNVIHPPQVIRDANSPFPSVTVCNLRPISPKGERVLQENSFKTPRNYAQDSNNYGIQYLLKKNKRKDYTTYTGTLNFPAYLESLPSNFERKSLGYNLSNFVINCQMSFLKGSQRSAVQCQAGTPYGTWRQFIHAQYLNCHTFDISPILQNNVTTLEMFLYLDENMNSNTCIDCFHAEIKSQLSGAVIAVHTPGTFPNINGRSINVTPGSLTEITLQNILNIQKAPPYGRCSPKTPKTVYMYGYNVSYSEFACRQITIQNEIIKKCGCRAIEYPFVSTDI-------PFCSSMPIFVPKRNCETPTAINSSCIKQMTIALNRIKCKI---SVINQYNKDVVESCSLPCSFHSYETDRSVSTWPTKLWQLEWLNS-------RVAKSFGMLNRT---------EFQPYRRIIELQKVGKEKEAM---DLLYQTNVLERNLLALLIDRPNFNLHKVEEKEVLSLTSFLSQSGGLFSIWLGLTMISLV 551          
The following BLAST results are available for this feature:
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SCNN1B1.970e-1121.71sodium channel epithelial 1 beta subunit [Source:H... [more]
SCNN1B2.033e-1121.71sodium channel epithelial 1 beta subunit [Source:H... [more]
SCNN1B2.233e-1121.71sodium channel epithelial 1 beta subunit [Source:H... [more]
SCNN1G1.000e-621.31sodium channel epithelial 1 gamma subunit [Source:... [more]
SCNN1A2.042e-619.59sodium channel epithelial 1 alpha subunit [Source:... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
del-49.457e-1221.24DEgenerin Like [Source:UniProtKB/TrEMBL;Acc:P9183... [more]
asic-25.327e-919.70Degenerin-like protein asic-2 [Source:UniProtKB/S... [more]
unc-1057.089e-921.94Degenerin-like protein unc-105 [Source:UniProtKB/... [more]
unc-1057.089e-921.94Degenerin-like protein unc-105 [Source:UniProtKB/... [more]
unc-1057.146e-921.94Degenerin-like protein unc-105 [Source:UniProtKB/... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
asic1b2.994e-622.74acid-sensing (proton-gated) ion channel 1b [Source... [more]
asic1c6.627e-622.32acid-sensing (proton-gated) ion channel 1c [Source... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
scnn1b1.198e-1019.77sodium channel, non voltage gated 1 beta subunit [... [more]
cldn163.946e-1019.72claudin 16 [Source:Xenbase;Acc:XB-GENE-971823][more]
lhx16.448e-1021.90LIM homeobox 1 [Source:Xenbase;Acc:XB-GENE-482482][more]
scnn1b3.386e-923.90sodium channel, non voltage gated 1 beta subunit [... [more]
cldn162.041e-822.36claudin 16 [Source:Xenbase;Acc:XB-GENE-971823][more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Scnn1b4.933e-1021.43sodium channel, nonvoltage-gated 1 beta [Source:MG... [more]
Scnn1b8.447e-824.03sodium channel, nonvoltage-gated 1 beta [Source:MG... [more]
Scnn1g3.072e-721.14sodium channel, nonvoltage-gated 1 gamma [Source:M... [more]
Asic25.511e-622.64acid-sensing (proton-gated) ion channel 2 [Source:... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q25011|FANA_CORAP1.663e-2019.52FMRFamide-activated amiloride-sensitive sodium cha... [more]
sp|H2QAR5|SCNNG_PANTR9.652e-1321.45Amiloride-sensitive sodium channel subunit gamma O... [more]
sp|P51169|SCNNB_XENLA5.139e-1120.10Amiloride-sensitive sodium channel subunit beta OS... [more]
sp|P51168|SCNNB_HUMAN1.072e-1021.71Amiloride-sensitive sodium channel subunit beta OS... [more]
sp|Q95165|SCNNB_CANLF6.825e-1020.74Amiloride-sensitive sodium channel subunit beta OS... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A094ZK548.717e-14141.48FMRFamide-activated amiloride-sensitive sodium cha... [more]
A0A4Z2DTC22.693e-13941.71FMRFamide-activated amiloride-sensitive sodium cha... [more]
A0A3Q0KJ872.984e-13941.30Putative amiloride-sensitive sodium channel OS=Sch... [more]
G4V8Q78.031e-13841.11Putative amiloride-sensitive sodium channel OS=Sch... [more]
G7YD976.257e-13239.89FMRFamide-activated amiloride-sensitive sodium cha... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
asic1a2.362e-623.24acid-sensing ion channel 1A-like [Source:NCBI gene... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
SCNN1G8.356e-920.30sodium channel epithelial 1 gamma subunit [Source:... [more]
SCNN1A5.332e-821.43sodium channel epithelial 1 alpha subunit [Source:... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO421371.040e-1620.18Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO374521.084e-623.59Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ENSORLT00000008662.22.941e-923.32acid sensing ion channel subunit 1 [Source:NCBI ge... [more]
ENSORLT00000031246.15.187e-823.53acid sensing ion channel subunit 1 [Source:NCBI ge... [more]
asic1a1.204e-721.69acid-sensing ion channel 1 [Source:NCBI gene;Acc:1... [more]
ENSORLT00000021925.22.332e-722.52acid-sensing ion channel 1C [Source:NCBI gene;Acc:... [more]
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BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000081650.10.000e+0100.00SMESG000081650.1[more]
SMESG000072389.10.000e+051.89SMESG000072389.1[more]
SMESG000013147.14.922e-13739.31SMESG000013147.1[more]
SMESG000013147.15.133e-13739.31SMESG000013147.1[more]
SMESG000064187.18.602e-8231.65SMESG000064187.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30023310 ID=SMED30023310|Name=FMRFamide-activated amiloride-sensitive sodium channel|organism=Schmidtea mediterranea sexual|type=transcript|length=1981bp
AATTTTAAATCAGCGAATGAAAATAAAATTACTTTGGAAAATGAAATGCT
AGCTTTCATATTAGTATTTATTTTATCGAAAATAAACCTCAAAACTCTGG
ATATAACAGAAAGATTAAATGAATAATGAGCTAGAAGACAAAACTGTTTA
CAACAGTTTGAAAGATTCAAATTGTGAAAAGTATAGGTCATCCCAAGTAT
ATCCACCAGTTTTTCATCTTCAAAGCAGTAGTTCAATTAATAATAAATAT
TCATCGAGAAAAGATTCTCGGTGTTTGGGGTGGTCTGCAATATCAAAACA
TTGGAAGGTATTTTGTGAAACCACATCATTACGAGGCGTACCGAGAATAG
CAAAAACTCGAGATCCAAAACGAAGGTTTTTGTGGATATTTTTTGTCACA
GCTTTTTTTCTTGCCTGTATTACTTGTATCGTTTTGTTAATCATGCAGTA
TCGACAATATGATGTCATTCATCAACCAAAAACCGTTTACAATAAACCAA
CACCTTTTCCTTCGTTGAGTTTCTGTAATTTGAGACCTTTATCTTCTCAC
AGTATCAAAACTCTGAAGAATAACGGCTTGAATTCTGTTTCAGAATATCT
AAAGCAATTGAAACAATCCATGGAAGATCTTCGTAAATCATCAAATATCA
CTGAAAGAAAATTACTGACAATGAGTTGGAATATAAATTCCTATTTTTTA
AATTTGCCAAATTCAACTCAACCGAATGACCTGGGCCATGACAGACTAGA
AATGGTTATGTATTGTCTTTTAATTTATAAACAAGGTATATATAACAGTG
GCATAGTTTGTGATAAAGCAGGTCACTGGGTCTCAACGTTAAATAGTATA
TACATTAACTGTCATACATTTATTGTAAATAAAAAATTTACAAATAAAAC
CTTTAGCATGGAAGTAGTATTGTATTTAGACCACGCAGATGAAATCTACT
GCAATGACTGCAACGAAATGAAAATATACTCTCAACTAACTGGAGTAAGA
TTGAACCTCCACAGTTCTGGAACATATCCAGAAATAATAGAAAAGGGAAT
AAATCTTATGCCTGGAACACTAACAGAAATAAAGTTCATTCCTAGACAAT
GGAACATGATGGAACCACCTCATGGAAAATGTAGCAAGCAAGTAAGCAAA
AAGATTTCATTCAACAAAGTTGAATTTCAATATTCGGAAGAAGCTTGTAA
AAGAAAGGTTTTGCAAGAGGAACTTGCAAAGAATTGTGATTGTGTTGATT
TCAACCAAGTTCCAGATGATTTAAATAACTATTTACAACACAAAAAAATC
TGTCAATATTTACCGGCAACTCCGTTTAGCAATGCAACATTATCCTCTTT
TAATCATTCACAAACCGCCGATTATTTGAATAAAACTCATTGTAATTTGC
AGACTTCGTCCGAAATTAATTACCAAAACAAATGTAACAGTCCGTGCACA
TTTTTCACATATGACACGACCATTAGTTCGGCTGAATGGCCAACAAAATC
TTTCCATACATCATTTTTGAAATCGCTTCGTGATTACATTCAAAAAAGAA
TGAGAAACTTTTACAATATCACCGAATCGACAAGATCCGCCTGGACAACC
ATAATCGAAGAACTGAAGCCCTATTTGAGTTTAATAGAGAAAATCGAGAA
AGAGGAAAATGTCACACTGAACAAAAAGTTATTAAACGATTTGAAATTCG
TGTCAAATAATTTTTTATCCATCCAAGTCGGCAGAACAAATTTTGACATA
ATTCTCGTGGAAGAAAAAGCAAGTGTATCATTGACAAATTTTCTCAGTCA
AACCGGAGGAATATTTAGCATTTGGAGTGGAATAACATTTTTTTGTATTG
TCGAAATTTTAGAACTGTTTATTCTAATTTTCGAGGAAATTTTCTCAAAA
AAACATTATCAAAACATTAGAAAATAGAAATGTCTGTCAAAATTTTATTT
ATTTTTCTCGATCAATTTAAAGATATGGAAC
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protein sequence of SMED30023310-orf-1

>SMED30023310-orf-1 ID=SMED30023310-orf-1|Name=SMED30023310-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=603bp
MNNELEDKTVYNSLKDSNCEKYRSSQVYPPVFHLQSSSSINNKYSSRKDS
RCLGWSAISKHWKVFCETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLAC
ITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLK
NNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNINSYFLNLPNST
QPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHT
FIVNKKFTNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSS
GTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNK
VEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPA
TPFSNATLSSFNHSQTADYLNKTHCNLQTSSEINYQNKCNSPCTFFTYDT
TISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELK
PYLSLIEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEK
ASVSLTNFLSQTGGIFSIWSGITFFCIVEILELFILIFEEIFSKKHYQNI
RK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR001873ENaC
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: biological process
TermDefinition
GO:0006814sodium ion transport
GO:0006810transport
GO:0006811ion transport
GO:0035725sodium ion transmembrane transport
Vocabulary: molecular function
TermDefinition
GO:0005272sodium channel activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 154..181
NoneNo IPR availableTMHMMTMhelixcoord: 87..109
NoneNo IPR availableTMHMMTMhelixcoord: 565..587
IPR001873Epithelial sodium channelPRINTSPR01078AMINACHANNELcoord: 292..310
score: 31.16
coord: 439..459
score: 37.33
coord: 126..142
score: 33.41
coord: 236..252
score: 25.41
IPR001873Epithelial sodium channelPFAMPF00858ASCcoord: 65..583
e-value: 1.1E-62
score: 212.5
IPR001873Epithelial sodium channelPANTHERPTHR11690AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATEDcoord: 61..594